Authors: Pallavi Subhraveti Ron Caspi Peter Midford Peter D Karp An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Ingrid Keseler Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Gcf_000421485Cyc: Desulfurobacterium sp. TC5-1 Cellular Overview Connections between pathways are omitted for legibility. Anamika Kothari

Na + phosphate

OadA PstB

Na + phosphate

Aromatic Compound Other Biosynthesis C1 Compound Utilization Carboxylate Tetrapyrrole Biosynthesis and Assimilation glutaminyl-tRNA gln Aminoacyl-tRNA Charging Biosynthesis Degradation a nascent peptidoglycan a peptidoglycan (1S,2R)-1- DNA combined biosynthesis via transamidation Polyprenyl Biosynthesis Macromolecule Modification 3-[(1-carboxyvinyl) H O D-glycero-β-D- a [glutamine- a nucleoside 8-amino-7- tetrapyrrole biosynthesis reductive TCA cycle I γ γ C-(indol-3- diphosphate 2 H O with exogenous Amine and Polyamine Biosynthesis chorismate biosynthesis acetate with (L-alanyl- -D- with (L-alanyl- -D- oxy]benzoate SAM ser ATP 2 ATP RNA ATP roseoflavin oxononanoate manno-heptose GTP synthetase]- triphosphate from 3-dehydroquinate I (from glutamate) conversion glutamyl-meso-2,6- glutamyl-meso-2,6- yl)glycerol 5'-phosphate DNA to form a glu trans, trans-farnesyl biosynthesis III tRNA-uridine 2-thiolation and selenation (bacteria) 3-phosphate 1-phosphate L-tyrosine recombinational spermidine biosynthesis III di-trans,poly-cis geranyl diphosphate 2-oxoglutarate to acetyl-CoA diaminopimeloyl- diaminopimeloyl-D- spermidine biosynthesis I putrescine diphosphate 3-dehydroquinate D-alanyl-D-alanine) alanine) tetrapeptide aminofutalosine RdgB/HAM1 family DNA- junctionHolliday -undecaprenyl biosynthesis pimelate glu acetate elongation biosynthesis I biosynthesis type I 3- 6-carboxyhexanoate- glutamate-- pentapeptide synthase tryptophan non-canonical D-glycero-beta-D- [glutamate-- directed RNA riboflavin junction phosphate biosynthesis cys acetate- factor 4: lepA SAM dehydroquinate -CoA ligase: tRNA ligase: MqnE: mqnE synthase purine NTP manno-heptose ammonia-ligase] polymerase: biosynthesis resolvase SAM IPP (2E,6E)-farnesyl IPP -CoA [+ 5 isozymes] resolution of dehydratase: aroD H153_RS09535 H153_RS0103970 aminofutalosine subunit pyrophosphatase: 1-phosphate adenylyltransferase: rpoB rpoC protein RuvX: ruvX an L-glutamyl- arg diphosphate an L-glutamyl- ligase: acs penicillin-binding recombinational S-adenosylmethionine di-trans,poly-cis- prenyltransferase: 3-dehydroshikimate pimeloyl-CoA synthase beta: trpB rdgB adenylyltransferase: H153_RS0104125 RibF: ribF F0F1 ATP Gln Glu NADP-dependent protein 2: [+ 2 isozymes] junction + + [tRNA ] S-adenosylmethionine H153_RS0107220 [tRNA ] acetyl-CoA + H H decarboxylase: decaprenylcistransferase: MqnE: mqnE tryptophan synthase inorganic rfaE2 phosphate H synthase gln decarboxylase: geranyl shikimate 8-amino-7- isocitrate dehydrogenase: H153_RS0101440 GDP formation of two Asp-tRNA(Asn) H153_RS0105370 arg DMAPP di-trans,octa-cisuppS glutamyl-tRNA an [L-cysteine desulfurase]- subunit alpha: diphosphatase: a [glutamine roseoflavin H153_RS0105370 agmatine diphosphate dehydrogenase: oxononanoate H153_RS0104890 intact strands /Glu-tRNA(Gln) S-adenosylmethionine -undecaprenyl reductase: S-sulfanyl-L-cysteine 6-amino-6- H153_RS0105850 H153_RS0102540 ADP-D-glycero-β- synthetase]-O RNA adenine imidazole S-adenosylmethionine prenyltransferase: H153_RS0108200 synthase: bioF a nascent peptidoglycan amidotransferase decarboxylase: diphosphate H153_RS09080 deoxyfutalosine met D-manno-heptose 4 -(5'-adenylyl) dinucleotide V-type ATP glycerol agmatinase: with D,D cross-links D-ala H + H + subunit GatB: gatB decarboxylase: H153_RS0107220 undecaprenyl- (8S)-8-amino-7- succinyl-CoA D-threo-isocitrate D-glyceraldehyde synthase phosphate H153_RS0108635 speB shikimate (S)-4-amino-5- (meso-diaminopimelate -L-tyrosine H153_RS0108635 diphosphate oxononanoate 3-phosphate trp + Asp-tRNA(Asn) synthase geranyl oxopentanoate containing) phosphate H dAdoMet agmatine phosphatase: shikimate kinase: a [TusA sulfur-carrier protein]- /Glu-tRNA(Gln) subunit putrescine dAdoMet putrescine diphosphate glutamate-1- H153_RS0102190 H153_RS0105455 S-sulfanyl-L-cysteine amidotransferase: semialdehyde + F0F1 ATP + HisF: hisF prenyltransferase: di-trans,octa-cis H H gatA gatC polyamine 2,1- synthase [+ 9 isozymes] H153_RS0107220 -undecaprenyl shikimate 3- a mature peptidoglycan a [DNA]-3'- a 5'-phospho- a mature a 5-phosphooxy- aminopropyltransferase: polyamine aminomutase: NAD + a D-tryptophanyl- a D-tyrosyl- an L-aspartyl- phosphate phosphate aconitate hydratase: (meso-diaminopimelate hydroxyl [DNA] peptidoglycan Trp Tyr a protein a protein L-glutamyl- aminopropyltransferase: hypoxanthine (n) [tRNA ] [tRNA ] Asn ATP ammonium speE (2E,6E)-farnesyl hemL H153_RS0101165 [tRNA ] Gln 3-phosphoshikimate 1- a [TusD sulfur-carrier protein]- containing) PRPP (meso-DAP biotin ATP-dependent [tRNA ] speE diphosphate ADP-forming succinate- Asp-tRNA(Asn) ATP- carboxyvinyltransferase: S-sulfanyl-L-cysteine containing) /Glu-tRNA(Gln) Clp protease dependent N 1 -(3-aminopropyl) 5-aminolevulinate -CoA ligase: sucC sucD DNA Asp-tRNA(Asn) aroA endolytic ligase D-tyrosyl-tRNA(Tyr) D-tyrosyl-tRNA(Tyr) amidotransferase ATP-binding protease agmatine spermidine 5-enolpyruvoyl- biotin--[acetyl-CoA- /Glu-tRNA(Gln) porphobilinogen succinate cis-aconitate transglycosylase hypoxanthine (NAD(+)) endolytic deacylase: deacylase: subunit GatB: gatB subunit ClpX: clpX subunit shikimate 3- H153_RS0106960 H153_RS0106960 carboxylase] ligase: amidotransferase synthase: hemB a [TusE sulfur carrier MltG: mltG phosphoribosyltransferase: hpt LigA: ligA transglycosylase Asp-tRNA(Asn) ATP-dependent HslV: hslV phosphate 34 H153_RS0104580 subunit GatB: gatB a uridine in tRNA succinate dehydrogenase/ [+ 3 isozymes] MltG: mltG /Glu-tRNA(Gln) Clp endopeptidase a peptide chorismate porphobilinogen protein]-S-sulfanylcysteine Asp-tRNA(Asn) fumarate reductase [+ 3 isozymes] amidotransferase: proteolytic spermidine synthase: Trp Tyr /Glu-tRNA(Gln) tRNA 2-thiouridine(34) iron-sulfur subunit: a mature peptidoglycan a mature peptidoglycan [DNA] NMN D-tryptophan a tRNA D-tyrosine a tRNA gatA gatC biotinyl-5'- subunit ClpP: clpP aroC hydroxymethylbilane IMP AMP an L-asparaginyl- amidotransferase: synthase MnmA: mnmA H153_RS0102310 aconitate hydratase: with (L-alanyl-γ-D- strand (non- a mature GlcNAc-1,6- adenylate a peptide synthase: hemC Asn gatA gatC glutamyl-meso-2,6- reducing terminus) peptidoglycan anhMurNAc- [tRNA ] chorismate succinate dehydrogenase/ H153_RS0101165 (n) diaminopimeloyl-D- (meso-DAP L-Ala-γ-D-Glu- preuroporphyrinogen a 2-thiouridine 34 in tRNA fumarate reductase an L-glutaminyl- iron-sulfur subunit: alanine) tetrapeptide containing) DAP-D-Ala uroporphyrinogen- [tRNA Gln ] tRNA uridine-5- fumarate H153_RS09370 citrate III synthase: carboxymethylaminomethyl(34) a DNA containing an N-terminal- an N-terminal- H153_RS0102575 a peptide with a an L-glutamyl- 34 synthesis GTPase MnmE: mnmE a 5,10-gly a uridine 34 phenylacetate an apurinic/ L-methionyl-L- L-methionyl-L- a cytidine lys 5-MTR-1-P tRNA charging ATP Gln methylenetetrahydrofolate in tRNA a tRNA precursor apyrimidinic site leader sequence threonyl-[protein] [tRNA ] alanyl-[protein] in tRNA Ile2 uroporphyrinogen-III tRNA uridine-5- fumarate hydratase: CTP Asp-tRNA(Asn) S-methyl-5- carboxymethylaminomethyl(34) ATP-citrate synthase thioribose-1- H153_RS0106030 phenylacetate--CoA /Glu-tRNA(Gln) gly a tRNA Gly phe a tRNA Phe thr a tRNA Thr trp a tRNA Trp tRNA asp asp arg a tRNA Arg glu a tRNA glu his a tRNA His elongator tRNA Met met initiator tRNA Met met cys a tRNA Cys ile a tRNA Ile tyr a tRNA Tyr synthesis enzyme MnmG: mnmG subunit beta protein tRNA uridine-5- endonuclease signal type I methionyl amidotransferase type I methionyl tRNA phosphate 1: H153_RS0104880 ligase: H153_RS0106385 CCA tRNA ser a tRNA ser leu a tRNA Leu pro a tRNA Pro val a tRNA Val a tRNA Ala ala lys a tRNA Lys a 5-carboxymethylaminomethyl- carboxymethylaminomethyl(34) III domain- peptidase aminopeptidase: subunit GatB: gatB aminopeptidase: lysidine(34) isomerase: asn tRNA Asn gln a tRNA Gln phenylacetate--CoA nucleotidyltransferase: 2-thiouridine 34 in tRNA synthesis GTPase MnmE: mnmE containing protein: I: lepB map map synthetase S-methyl-5-mtnA glycine--tRNA ligase: phenylalanine-- threonine- tryptophan- aspartate- arginine-- glutamate-- histidine-- methionine- methionine- cysteine-- isoleucine- tyrosine-- ligase: H153_RS0106390 H153_RS0100780 Asp-tRNA(Asn) tRNA uridine-5- H153_RS0106175 /Glu-tRNA(Gln) TilS: tilS thio-D-ribulose H153_RS0106250 tRNA ligase: pheS serine--tRNA -tRNA -tRNA -tRNA tRNA ligase: tRNA ligase: tRNA ligase: -tRNA -tRNA tRNA ligase: leucine--tRNA ligase: proline--tRNA ligase: valine--tRNA ligase: -tRNA alanine--tRNA tRNA ligase: lysine--tRNA carboxymethylaminomethyl(34) endonuclease III: an N-terminal L- amidotransferase: an N-terminal L- 1-phosphate H153_RS0106255 H153_RS0104070 ligase: serS ligase: thrS ligase: trpS ligase: aspS H153_RS0102985 H153_RS0103970 H153_RS0103985 ligase: metG ligase: metG H153_RS0105890 H153_RS0106945 H153_RS0107305 H153_RS0107530 ligase: ileS ligase: alaS H153_RS0108330 ligase: lysS (S)-malate acetyl-CoA a tRNA synthesis enzyme MnmG: mnmG H153_RS0101975 a leader sequence a peptide met met 34 pyruvate synthase: phenylacetyl-CoA diphosphate threonyl-[protein] gatA gatC alanyl-[protein] a lysidine 34 AMP containing a an L-glutaminyl- a 5-aminomethyl-2-thiouridine in tRNA in tRNA Ile2 an L-phenylalanyl- an L-tryptophanyl- an L-methionyl- an L-methionyl- an L-asparaginyl- an L-glutaminyl- H153_RS0100895 3' CCA end [tRNA Gln ] a glycyl-[tRNA Gly ] an L-seryl-[tRNA ser ] an L-threonyl-[tRNA Thr ] an L-aspartyl-[tRNA asp ] an L-arginyl-[tRNA Arg ] an L-glutamyl-[tRNA Glu ] an L-histidyl-[tRNA His ] an L-cysteinyl-[tRNA Cys ] an L-leucyl-[tRNA Leu ] an L-prolyl-[tRNA Pro ] an L-valyl-[tRNA Val ] an L-isoleucyl-[tRNA Ile ] an L-alanyl-[tRNA Ala ] an L-tyrosyl-[tRNA Tyr ] an L-lysyl-[tRNA Lys ] a 5-carboxymethylaminomethyluridine 34 a 3'-terminal a 5'-phospho- [tRNA Phe ] [tRNA Trp ] [elongator tRNA Met ] [initiator tRNA Met ] [tRNA Asn ] [tRNA Gln ] malate dehydrogenase: mdh pyruvate ferredoxin a 7,8-dihydrofolate oxidoreductase subunit in tRNA unsaturated sugar [DNA] beta: H153_RS0100910 a 5-methylaminomethyl- α a 2'- an N-terminal- 2-thiouridine 34 in tRNA a [ribosomal -Kdo-(2->4) phosphoenol an apo-[FeFe] a sulfurated α deoxyribonucleoside CO Ala L-methionyl-L- protein S12] - -Kdo-(2->6) a myristoyl-[acp] [DNA] a PII protein a glycyl-[tRNA ] pyruvate hydrogenase AMP tRNA 2-selenouridine(34) [sulfur carrier] 89 dGDP Nucleoside and Nucleotide Biosynthesis L-aspartate -(lauroyl)-lipid 5'-triphosphate UTP seryl-[protein] subunit [FeFe] synthase MnmH: mnmH IV (E. coli) Cell Structure Biosynthesis oxaloacetate pyruvate A anaerobic hydrogenase 5'/3'- a 5-methylaminomethyl-2-(S- superpathway of purine nucleotides de novo biosynthesis I phosphoenolpyruvate 30S ribosomal DNA polymerase III: carbon-monoxide [protein-PII] D-tyrosyl-tRNA(Tyr) type I methionyl H-cluster nucleotidase UMP biosynthesis III superpathway of guanosine superpathway of pyrimidine CMP phosphorylation 34 peptidoglycan biosynthesis I (meso-diaminopimelate containing) geranyl)thiouridine in tRNA synthase: ppsA protein S12 lipid A biosynthesis H153_RS0107270 uridylyltransferase: deacylase: pyruvate aminopeptidase: maturation SurE: surE Fatty Acid and Lipid Biosynthesis nucleotides de novo biosynthesis I nucleobases salvage lipid IV biosynthesis (P. putida) dehydrogenase A lipid IV biosynthesis (E. coli) tRNA 2-selenouridine(34) methylthiotransferase acyltransferase: dnaN glnD H153_RS0106960 kinase: pyk map GTPase PRPP CMP Secondary Metabolite Biosynthesis A catalytic uracil UDP-N-acetyl-α-D-glucosamine synthase MnmH: mnmH RimO: rimO H153_RS0100860 [+ 5 isozymes] HydF: hydF adenosine palmitate biosynthesis gln hydrogencarbonate (d)CMP kinase: a (3R)-3- a (3R)-3- subunit: cooS biotin-carboxyl carrier acyl-CoA hydrolysis amidophosphoribosyltransferase: IMP uracil formaldehyde oxidation [+ 2 isozymes] (type II fatty acid synthase) H153_RS0101985 UDP-N-acetylglucosamine hydroxydecanoyl- UDP-N-acetyl- hydroxytetradecanoyl- a 5-methylaminomethyl-2-(Se- Carbohydrate Degradation a uridylylated an N-terminal an active [FeFe] phosphoribosyltransferase: methylerythritol phosphate pathway I UDP-N-acetyl- VII (THF pathway) α a tRNA Ala protein assembly H153_RS0101455 CDP preQ biosynthesis [acp] α-D-glucosamine phospho)selenouridine 34 in tRNA a [ribosomal -D-Kdo-(2->4) gly pyruvate met L-seryl-[protein] hydrogenase 0 1-carboxyvinyltransferase: [acp] α-D-glucosamine an unsulfurated [DNA] a reduced PII protein a 2,3,4-saturated carbamoyl- IMP H153_RS0103990 5'-deoxyadenosine met protein S12]-3- acyl-carrier protein -α-D-Kdo-(2->6) CO H + dGTP subunit a [biotin carboxyl- β gly nucleoside- D-glyceraldehyde murA formaldehyde 2 ferredoxin [iron- an acetoacetyl-[acp] fatty acyl CoA 5-phospho- -D-ribosylamine phosphate dehydrogenase: UMP pyruvate acyl-ACP--UDP-N- tRNA 2-selenouridine(34) D-mannose degradation methylsulfanyl- [sulfur carrier] -lipid A (E. coli) carrier protein]-L-lysine acyl-CoA diphosphate kinase: 3-phosphate α acyl-ACP--UDP-N- synthase MnmH: mnmH sulfur] cluster synthase guaB UMP kinase: UDP-N-acetyl- -D-glucosamine-enolpyruvate acetylglucosamine O- L-aspartate 89 3-oxoacyl-[acyl- biotin--[acetyl-CoA- thioesterase: H153_RS0103240 GTP acetylglucosamine O- D-mannopyranose large H153_RS0107815 acyltransferase: lpxA a 5-methylaminomethyl-2- phosphoenolpyruvate carrier-protein] carboxylase] ligase: H153_RS09515 phosphoribosylamine- 1-deoxy-D-xylulose- GTP UDP-N-acetylmuramate acyltransferase: lpxA a 5,10- 6-phosphate a 2,3,4-saturated subunit: carB XMP CTP selenouridine 34 in tRNA -glycine ligase: purD UDP cyclohydrolase dehydrogenase: murB methylenetetrahydrofolate mannose-1-phosphate 34 a 1-acyl-2- (E)-4-hydroxy-3- reductase: fabG H153_RS0104580 fatty acid 5-phosphate ala UDP-3-O-[(3R)-3- a 5,10- a 2-thiouridine a 2-oxo a 2'-deoxyribonucleoside an N-modified a reduced phosphoenol an L-cysteinyl- a [biotin carboxyl- glutamine- 7,8- I FolE: folE glu α UDP-3-O-[(3R)-3- bifunctional guanylyltransferase/ arachidonoyl- methylbut-2-en- nucleoside-diphosphate synthase: UDP-N-acetyl- -D-muramate hydroxydecanoyl]- methylenetetrahydrofolate in tRNA carboxylate 5'-triphosphate [DNA] aminoacyl-[tRNA] superoxide dADP pyruvate [tRNA Cys ] IMP a (3R)-3- carrier protein]-N glutamine- dihydroneopterin hydroxymyristoyl]-N- mannose-6- sn-glycerol rubredoxin 1-yl diphosphate GAR hydrolyzing kinase: H153_RS0103240 H153_RS0107340 N-acetyl-α-D- methylenetetrahydrofolate flavodoxin- hydroxybutanoyl-[acp] 6 hydrolyzing GMP 3'-triphosphate acetyl-α-D-glucosamine phosphate isomerase: CTP -biotinyl-L-lysine carbamoyl- glutamate racemase: UDP-N-acetylmuramate- dehydrogenase/ 3-phosphate dependent 5'/3'- 3-hydroxyacyl- synthase: guaA UTP 6-carboxytetrahydropterin glucosamine UDP-3-O-[3- tRNA processing H153_RS0101330 tRNA uridine-5- 2-oxoacid:ferredoxin phosphoribosylglycinamide phosphate 1-deoxy-D-xylulose H153_RS0107415 -L-alanine ligase: UDP-3-O-[3- methenyltetrahydrofolate DNA polymerase/ aminoacyl-tRNA aminoacyl-tRNA (E)-4-hydroxy- nucleotidase ACP dehydratase synthase: hydroxymyristoyl] N- F6P carboxymethylaminomethyl(34) oxidoreductase desulfoferrodoxin: formyltransferase: synthase CTP synthase: 5-phosphate H153_RS0108755 hydroxymyristoyl] N- cyclohydrolase FolD: folD 3'-5' exonuclease phosphatidate hydrolase: pyruvate hydrolase: 3-methylbut- SurE: surE FabZ: fabZ GMP H153_RS0102705 acetylglucosamine a polycistronic synthesis GTPase MnmE: mnmE subunit beta: H153_RS0100190 a [biotin carboxyl- H153_RS0108515 small H153_RS0101950 D-glt acetylglucosamine a 5,10- PolX: polX cytidylyltransferase: H153_RS0106145 kinase: pyk H153_RS0106145 2-enyl- 6-carboxy-5,6,7,8- deacetylase: lpxC tRNA precursor tRNA uridine-5- H153_RS0101035 carrier-protein dimer]- subunit: carA UDP-N-acetyl-α-D-muramoyl-L-alanine deacetylase: lpxC methenyltetrahydrofolate [+ 5 isozymes] H153_RS09765 diphosphate inosine a (2E)-but-2-enoyl-[acp] FGAR CTP tetrahydropterin UDP-3-O-(3- carboxymethylaminomethyl(34) N 6 -biotinyl-L-lysine guanylate kinase: UDP-3-O-(3- synthase: ispG hydroxymyristoyl) bifunctional synthesis enzyme MnmG: mnmG a reduced an uncharged an oxidized 2-C-methyl-D- 7-carboxy-7- UDP-N-acetylmuramoyl- an N-modified Cys acetyl-CoA phosphoribosylformylglycinamidine carbamoyl H153_RS0107610 MEP hydroxydecanoyl) -α-D-glucosamine methylenetetrahydrofolate an acyl-CoA CO H + a CDP-1-acyl- cys a tRNA erythritol-2,4- asp 2 ferredoxin [iron- tRNA rubredoxin pyruvate synthase subunit PurL: purL phosphate guanine and guanosine salvage deazaguanine L-alanine--D- -α-D-glucosamine UDP-3-O-(3- [DNA] 2-arachidonoyl- amino acid dATP carboxylase dehydrogenase/ sulfur] cluster cyclodiphosphate 2-C-methyl-D- synthase QueE: glutamate ligase: murD UDP-3-O-(3- hydroxymyristoyl) a tRNA precursor a tRNA precursor a 5-aminomethyl-2- glycerol biotin phosphoribosylformylglycinamidine GDP methenyltetrahydrofolate a 7,8-dihydrofolate acetyl-CoA erythritol 4-phosphate H153_RS09795 hydroxymyristoyl) glucosamine N- with a 5' with a 5' thiouridine 34 in tRNA carboxylase synthase: purS purQ aspartate meso-diaminopimelate α cyclohydrolase FolD: folD a butanoyl-[acp] carboxylase guanosine cytidylyltransferase: 7-carboxy-7- UDP-N-acetyl- -D-muramoyl- glucosamine N- acyltransferase: extension and extension and a subunit: accC carbamoyltransferase an N 10 - carboxyltransferase FGAM purine-nucleoside ispD deazaguanine L-alanyl-D-glutamate acyltransferase: lpxD a long 3' trailer short 3' extension beta-ketoacyl- acetyl-CoA catalytic subunit: formyltetrahydrofolate UDP-N-acetyl-α-D-muramoyl- an N-terminal- an N-terminal- a peptide with an unstable subunit beta: nucleoside- phosphorylase: 4-(cytidine 5'- lpxD UDP-2-N,3-O-bis[(3R)- ribonuclease quinoxaline-2- 37 a D-aspartyl- H153_RS0103275 7-cyano-7- di-trans,octa-cis- γ an acyl-[acyl- an adenosine O-ureido-L- ACP synthase carboxylase phosphoribosylformylglycinamidine UDP-N-acetylmuramoyl- D-ala L-alanyl- -D-glutamyl-L- aryl-carrier protein DMAPP L-methionyl-L- asp asp L-methionyl-L- an N-terminal RecA filament- H153_RS09520 diphosphate kinase: H153_RS0107970 diphospho)-2-C- deazaguanine UDP-2-N-[(3R)-3- 3-hydroxytetradecanoyl]- P protein formyltetrahydrofolate undecaprenyl phosphate carboxyl adenylate carrier protein] in tRNA [tRNA ] II: fabF biotin cyclo-ligase: H153_RS0108510 L-alanyl-D-glutamate-- lysyl-D-alanyl-D-alanine cysteinyl-[protein] homoserine valyl-[protein] L-methionine DNA complex H153_RS0103240 guanine methyl-D-erythritol synthase hydroxydodecanoyl]- α-D-glucosamine ribonuclease component: deformylase: purU DNA carboxylase N-carbamoyl- 2, 6-diaminopimelate D-alanine--D-alanine repair dGDP 4-(cytidine 5'- QueC: queC 3-O-[(3R)-3- PH: rph rnpA a 3-oxohexanoyl-[acp] subunit: accC AIR L-aspartate diphospho) ligase: H153_RS0105120 ligase: H153_RS0105130 hydroxydecanoyl]- a tRNA precursor formate phospho-N- phosphate tRNA (adenosine(37)-N6) type I methionyl argininosuccinate D-tyrosyl-tRNA(Tyr) type I methionyl type I methionyl protein a [carboxyl-carrier hypoxanthine acyl carrier GTP -2-C-methyl- preQ α-D-glucosamine a tRNA with a short Amino Acid Degradation acetylmuramoyl- acyltransferase -dimethylallyltransferase aminopeptidase: synthase: deacylase: aminopeptidase: aminopeptidase: RecO: 3-oxoacyl-[acyl- protein dimer]-N 6 - 5-(carboxyamino) dihydroorotase: nucleoside- phosphoribosyltransferase: hpt 0 UDP-N-acetyl-α-D-muramoyl-L-alanyl- D-alanyl-D-alanine protein: acpP D-erythritol lipid X precursor with 3' extension pentapeptide- PlsX: plsX MiaA: miaA map H153_RS0107625 H153_RS0106960 map map a stabilizedrecO carrier-protein] carboxybiotinyl-L-lysine imidazole ribonucleotide H153_RS0103265 diphosphate kinase: γ-D-glutamyl-meso-2,6-diaminopimelate kinase: ispE a 5' extension L-glutamate transferase: RecA filament- reductase: fabG mutase: purE H153_RS0103240 lipid-A- L-citrulline degradation L-valine degradation 6 GMP 2-phospho-4-(cytidine H153_RS0105360 a quinoxaline-2- N -(3-methylbut- DNA complex (S)-dihydroorotate UDP-N-acetylmuramoyl- disaccharide ribonuclease degradation VI III (oxidative an N-terminal L- an N-terminal a (3R)-3- asp CAIR 5'-diphospho)-2-C- lipid X (P. putida) ribonuclease carboxyl-[aryl- an acyl phosphate 2-en-1-yl)- canavaninosuccinate tRNA asp dGTP tripeptide--D-alanyl-D- PH: rph (to pyruvate) AMP acyl-carrier protein met cysteinyl-[protein] D-aspartate met L-valyl-[protein] met a peptide methyl-D-erythritol synthase: lpxB P protein Stickland reaction) carrier protein] adenosine 37 hydroxyhexanoyl-[acp] dihydroorotate myo-inositol biosynthesis alanine ligase: murF L-citrulline undecaprenyl-diphospho-N- UMP fatty acid elongation -- saturated 2-C-methyl-D- lipid-A- lipid A disaccharide component: glu γ in tRNA 3-hydroxyacyl- dehydrogenase ornithine val acetylmuramoyl-L-alanyl- -D- phosphoribosylaminoimidazolesuccinocarboxamide erythritol 2,4- α disaccharide (E. coli) rnpA ACP dehydratase electron D-glucopyranose UDP-N-acetyl- -D-muramoyl-L- carbamoyltransferase: branched-chain glutamyl-L-lysyl- D-alanyl-D-alanine synthase: H153_RS0101460 cyclodiphosphate γ synthase: lpxB FabZ: fabZ 6-phosphate alanyl- -D-glutamyl-meso-2,6- di-trans,octa-cis-undecaprenyl phosphate tetraacyldisaccharide an acetoacetyl-[acp] transfer subunit: synthase: inositol-3-phosphate lipid A argF amino acid diaminopimeloyl-D-alanyl-D-alanine 4'-kinase: lpxK carbamoyl phosphate α an N-terminal- H153_RS0105915 H153_RS0102640 synthase: disaccharide transaminase: di-trans,octa-cis- UDP-N-acetyl- -D- a peptidoglycan α-Kdo an L-asparaginyl- a (2E)-hex-2-enoyl-[acp] SAICAR H153_RS0104035 muramoyl-L-alanyl-γ-D- ala a pimeloyl-[acp] 2-methylbutanoate dimer (generic) a type IV prepilin CTP L-methionyl- met 3',5'-ADP dihydroorotate pyrimidine deoxyribonucleotides de novo biosynthesis III H153_RS0108545 phospho-N-acetylmuramoyl- (P. putida) lipid IV (E. coli) an uncharged (2S, 3S)-3- 3-methyl-2- undecaprenyl phosphate [tRNA Asn ] 2-C-methyl-D-erythritol- A carbamoyl-phosphate glycyl-[protein] dehydrogenase: glutamyl-L-lysyl-D-alanine bifunctional 3'(2'),5'- adenylosuccinate lyase: 2,4-cyclodiphosphate Ins(3)P pentapeptide- transferase: tetraacyldisaccharide tRNA methylaspartate synthase large oxobutanoate H153_RS0108275 UDP CTP endolytic 3-deoxy-manno- glutamate N- bisphosphate H153_RS0104100 H153_RS0105360 4'-kinase: lpxK subunit: carB ketoisovalerate acetate- PRPP flavodoxin- inositol phospho-N- 8-amino-7- transglycosylase octulosonate aminoacyl-tRNA type I methionyl acetyltransferase/ nucleotidase a 3-oxoacyl-[acp] orotate lipid IV oxidoreductase: -CoA prepilin peptidase: AICAR dependent monophosphatase: undecaprenyldiphospho-N-acetylmuramoyl- A glutamine-hydrolyzing acetylmuramoyl- oxononanoate MltG: mltG cytidylyltransferase: hydrolase: aminopeptidase: amino-acid CysQ: cysQ 3-oxoacyl- dUDP CDP (P. putida) H153_RS0101040 ligase: acs H153_RS0101540 a hexanoyl-[acp] (E)-4-hydroxy- H153_RS0102835 L-alanyl-γ-D-glutamyl-meso-2,6- carbamoyl-phosphate pentapeptide- synthase: bioF kdsB H153_RS0106145 map acetyltransferase [acyl-carrier- orotate queuosine [+ 3 isozymes] AMP bifunctional nucleoside-diphosphate 3-methylbut- diaminopimeloyl-D-alanyl-D-alanine mesaconate synthase small isobutanoyl-CoA transferase: ArgJ: argJ beta- protein] phosphoribosyltransferase: biosynthesis I (de novo) (2S)-2- beta-ketoacyl- phosphoribosylaminoimidazolecarboxamide kinase: H153_RS0103240 2-enyl- myo-inositol undecaprenyldiphospho- subunit: carA H153_RS0105360 N-acetyl-L- ketoacyl- reductase: H153_RS0108225 (8S)-8-amino-7- methylbutanoyl- diphosphate GlcNAc-1,6- a cleaved type an N-terminal ACP synthase formyltransferase/IMP cyclohydrolase: purH diphosphate muramoylpentapeptide beta-N- AMP a lipid II a peptide CMP-Kdo tRNA Asn methionine ACP fabG dUTP dCDP preQ carbamate L-methionine degradation oxononanoate acyl-carrier protein CoA anhydro-MurNAc- IV prepilin asn met glycyl-[protein] II: fabF synthase: ispG acetylglucosaminyltransferase: 0 undecaprenyl-diphospho-N synthase a (3R)-3- FAICAR preQ(1) I (to L-homocysteine) UMP pentapeptide a 2,3,4-saturated orotidine 5'- nucleoside triphosphate nucleoside-diphosphate (E)-4-hydroxy-3- murG -acetylmuramoyl-L-alanyl-γ- II: fabF hydroxyacyl-[acyl- synthase: (S)-citramalate a 3-oxooctanoyl-[acp] fatty acyl-[acp] bifunctional phosphate pyrophosphohydrolase: kinase: H153_RS0103240 methylbut-2-en- isobutanoate D-glutamyl-L-lysyl- D-alanine carrier protein] mazG lipid II (meso diaminopimelate containing) queF met 3-hydroxyacyl- phosphoribosylaminoimidazolecarboxamide orotidine-5'- superpathway of dCTP 1-yl diphosphate preQ methionine 3-oxoacyl-[acyl- 1 citramalate ACP formyltransferase/IMP cyclohydrolase: purH phosphate adenosine nucleotides dUMP CO adenosyltransferase: an N 6 -L- a [protein] N- GDP-α-D- D-glycero-D- (3R,5S)-3- carrier-protein] 2 a D-aminoacyl- (2R,3S)-3- tRNA synthase: a sulfurated 37 a 5-L-glutamyl- a RNA-DNA hybrid reductase: fabG dehydratase decarboxylase: de novo biosynthesis I FAD-dependent 4-hydroxy- H153_RS0102070 threonylcarbamoyladenine an amino acid DL-allothreonine terminal-formyl- isopropylmalate mannose manno-heptose hydroxy-1- FabZ: fabZ guanosine(34) cimA [sulfur carrier] [peptide] [tRNA] IMP pyrF thymidylate synthase: thyX 3-methylbut- L-arginine SAM in tRNA L-methionine 3-isopropylmalate 7-phosphateD-glycero- pyrroline-5- a (3R)-3- a trans-2- IMP 2-enyl transglycosylase dehydratase carboxylate UMP asp dTMP degradation GDP-mannose beta-D- pyrroline-5- hydroxyoctanoyl-[acp] a 2,3,4-saturated enoyl-[acyl- xanthine and 4-hydroxy- diphosphate Tgt: tgt ribonuclease HII: small subunit: leuD a 7-aminomethyl-7- acetate pyruvate III (arginine tRNA (N(6)-L- gamma- serine D-tyrosyl-tRNA(Tyr) peptide mannosyl hydrolase: manno- carboxylate 3-hydroxyacyl- fatty acyl-[acp] carrier protein] dTMP kinase: xanthosine salvage 3-methylbut- reductase: H153_RS09705 34 decarboxylase/ threonylcarbamoyladenosine(37) glutamyltransferase: hydroxymethyltransferase: deacylase: deformylase: 3-isopropylmalate H153_RS0101325 heptose-7- reductase: ACP dehydratase H153_RS0100695 2-enyl deazaguanosine IMP dehydrogenase: adenylosuccinate ispH agmatinase pathway) -C(2))- methylthiotransferase H153_RS0105930 H153_RS0104720 H153_RS0106960 def dehydratase phosphate proC FabZ: fabZ diphosphate in tRNA arg guaB synthase: dTDP xanthosine SAH MtaB: mtaB large subunit: leuC βkinase: rfaE1 Hyp reductase: tRNA preQ1(34) S- a nucleoside 5'- (2S)-2- D-glycero- -D- adenine and H153_RS0107725 an α-(5-L- DNA D-mannose a (2E)-oct-2-enoyl-[acp] nucleoside-diphosphate purine-nucleoside ispH adenosylmethionine L-glutamate an uncharged an N-terminal L- monophosphate isopropylmalate GDP manno-heptose IPP 6 glutamyl)- acetaldehyde formate fatty acid biosynthesis adenosine salvage I kinase: H153_RS0103240 phosphorylase: ribosyltransferase- degradation II adenosylhomocysteinase: a 2-methylsulfanyl-N -L- a peptide gly a D-amino acid tRNA methionyl-[protein] 1,7-bisphosphate agmatine 37 an unsulfurated adenylo-succinate H153_RS0107970 isomerase QueA: queA H153_RS0102000 threonylcarbamoyladenine 5'-deoxyadenosine met amino acid initiation (type II) dTTP [sulfur carrier] XMP xanthine 34 in tRNA asp adenosine adenylosuccinate an epoxyqueuosine glu agmatinase: acetyl-CoA L-homocysteine purine-nucleoside lyase: in tRNA speB acetyl-CoA 6 an octanoyl-[acp] glutamine-hydrolyzing adenylosuccinate phosphorylase: H153_RS0104100 epoxyqueuosine N -(3-methylbut- an N-formyl-L- guanosine 2251 D-firefly a supercoiled carboxylase L-glutamine pyruvate carbamoyl fumarate aci-nitroethane H O RNA GMP synthase: guaA synthase: H153_RS0107970 DMAPP reductase QueH: putrescine a sulfurated [sulfur carrier] 2-en-1-yl)- methionylaminoacyl- L-ornithine asp 2 asp degradation II phosphate in 23S rRNA luciferyl-CoA duplex DNA beta-ketoacyl- carboxyltransferase H153_RS0107725 adenine guanine and guanosine salvage II H153_RS0103940 adenosine 37 in tRNA tRNA 23S rRNA ATP- subunit beta: AMP XMP ACP synthase a queuosine 34 (guanosine(2251) dependent H153_RS09520 GMP aspartate L-glutamine gln pyruvate, nitronate acyl-CoA II: fabF adenylo-succinate adenine in tRNA peptide ornithine L-aspartate -2'-O)- ribonuclease DNA malonyl-CoA guanosine ammonia-lyase: degradation I NADPH- tRNA (N6-isopentenyl phosphate dikinase: oxidase: monooxygenase: thioesterase: phosphoribosyltransferase: adenylate kinase: adenosine(37)-C2)- deformylase: carbamoyltransferase: methyltransferase PH: rph helicase a 3-oxodecanoyl-[acp] adenylosuccinate lyase: H153_RS0100385 dependent H153_RS0106260 nadB H153_RS09725 H153_RS09515 ACP S- guanylate kinase: H153_RS0100625 H153_RS0106495 methylthiotransferase def argF 2-O- RlmB: rlmB RecG: recG H153_RS0104100 gln glutamate a single malonyltransferase: H153_RS0107610 fumarate MiaB: miaB methylguanosine 2251 3-oxoacyl-[acyl- AMP imidazole glycerol synthase: gltA phosphoenol a nucleoside stranded DNA fabD lipoprotein posttranslational H + 2-iminosuccinate succinate acetaldehyde nitrite in 23S rRNA D-firefly luciferin RNA carrier-protein] ADP guanine phosphate synthase glutamate pyruvate diphosphate a L-methionylaminoacyl- diphosphate AMP modification 6 AMP formate L-citrulline reductase: fabG GDP subunit HisF: hisF synthase large N -(3-methylbut-2-en- tRNA a malonyl-[acp] 5'-deoxyadenosine 1-yl)-2-(methylsulfanyl) an unsulfurated a [prolipoprotein]- [+ 9 isozymes] subunit: gltB met a (3R)-3- hypoxanthine 37 [sulfur carrier] adenylate kinase: L-cysteine glu adenosine in tRNA hydroxydecanoyl-[acp] phosphoribosyltransferase: hpt glu ketoacyl-ACP H153_RS0106495 prolipoprotein 3-hydroxyacyl- synthase III: fabH α diacylglyceryl a nascent peptidoglycan di-trans,octa-cis UDP- -D- 34 a thiocarboxylated a peptide with an [amino-group carrier ACP dehydratase nucleoside- a uridine a uracil in DNA an acyl-CoA H O carbonic acid dADP GMP transferase: lgt -undecaprenyl galactose canavaninosuccinate protein]-C-terminal-γ- 2 diphosphate kinase: ADP (meso-DAP containing) in tRNA [SAMP] C- an N-terminal a protein FabZ: fabZ an acetoacetyl-[acp] a [prolipoprotein]- phosphate (L-glutamyl)-L-glutamate H153_RS0103240 terminal glycine Xaa-L-proline nucleoside- S-1,2-diacyl-sn- a (2E)-dec-2-enoyl-[acp] endolytic uracil-DNA acetylglutamate acyl-CoA carbonic endopeptidase diphosphate kinase: glyceryl-L-cysteine tRNA 2- argininosuccinate transglycosylase undecaprenyl- leucyl glycosylase: kinase: argB thioesterase: anhydrase: La: lon H153_RS0103240 thiouridine(34) lyase: argH dGDP pyrimidine deoxyribonucleotide phosphorylation signal MltG: mltG phosphate galactose aminopeptidase: H153_RS09690 an [amino-group carrier H153_RS09515 H153_RS09330 synthase peptidase [+ 3 isozymes] phosphotransferase H153_RS0105625 protein]-C-terminal- a peptide GTP dATP dTMP dCMP Inorganic Nutrient Metabolism WbaP: wbaP MnmA: mnmA γ-(5-phospho-L- dADP II: lspA uracil nucleoside- dTMP kinase: (d)CMP kinase: a peptide with L-canavanine fumarate an apyrimidinic glutamyl)-L-glutamate a carboxylate CO H O a decanoyl-[acyl-carrier protein] a mature peptidoglycan a nascent peptidoglycan 2 2 H153_RS0100695 H153_RS0101985 an (S-diacyl- α a [SAMP] C- a 2-thiouridine 34 a proteinogenic site in DNA diphosphate kinase: nucleoside- a lipoprotein selenate reduction assimilatory with (L-alanyl-γ-D-glutamyl- (meso-DAP containing) -D-galactosyl- UMP an N-terminal dTDP dCDP sn-glyceryl) thiosulfate oxidation III (multienzyme complex) terminal glycine in tRNA amino acid beta-ketoacyl- H153_RS0103240 diphosphate kinase: signal peptide sulfate reduction IV meso-2,6-diaminopimeloyl- with GlcNAc terminus diphosphoundecaprenol L-proline -L-cysteinyl- ACP synthase H153_RS0103240 nucleoside- nucleoside- signal selenate D-alanine) tetrapeptide diphosphate kinase: diphosphate kinase: [apolipoprotein] a [SoxY protein]-L-cysteine II: fabF peptide sulfate sulfate dGTP dATP H153_RS0103240 H153_RS0103240 peptidase adenylyltransferase: sat sulfate a 5-methylaminomethyl- a [protein]-S- a uridine 34 α-D- a [histone]-N 6 - (+)-7-epi- a double-stranded a 3-oxododecanoyl-[acp] dTTP dCTP SppA: sppA adenosine 5'- geranyl 34 3-methylbutanoate H O protoheme acetyl-CoA an unfolded adenylyltransferase: sat selenophosphate 2-thiouridine sulfanyl-L-cysteine in tRNA glucopyranose acetyl-L-lysine jasmonoyl-CoA 2 oligonucleotide an N-acyl-(S- phosphoselenate diphosphate in tRNA UTP bifunctional protein 3-oxoacyl-[acyl- APS 1-phosphate acetyl-CoA diacyl-sn-glyceryl) a peptide a [SoxY protein]-S- oligoribonuclease/ carboxylase carrier-protein] acetate- acyl-CoA chaperonin -L-cysteinyl- adenylyl-sulfate sulfosulfanyl-L-cysteine tRNA 2- histone deacetylase: PAP phosphatase ferrochelatase: biotin reductase: fabG tRNA 2- -CoA UTP--glucose- thioesterase: GroEL: groL [lipoprotein] kinase: cysC thiouridine(34) H153_RS0103120 NrnA: hemH carboxylase selenouridine(34) ligase: acs 1-phosphate H153_RS09515 a (3R)-3- Cofactor, Carrier, and Vitamin Biosynthesis selenite cytochrome c: synthase H153_RS0106275 subunit: accC synthase MnmA: mnmA uridylyltransferase a protein hydroxydodecanoyl-[acp] PAPS H153_RS0107955 MnmH: mnmH GalU: galU a nucleoside 5'- [+ 4 isozymes] 3-hydroxyacyl- flavin biosynthesis I (bacteria and plants) 3-methylbutanoyl- (+)-7-epi- monophosphate 2+ superpathway of coenzyme A biosynthesis I (bacteria) S-adenosyl-L-methionine salvage II 6 37 phosphoadenylyl- acetate a [histone]-L-lysine Fe protoporphyrin IX malonyl-CoA pyridoxal 5'-phosphate biosynthesis I NAD salvage pathway I (PNC VI cycle) 4-amino-2-methyl-5- N -L-threonylcarbamoyladenosine a [SoxY protein]-S- a [SoxY protein]-S diphosphate 34 ACP dehydratase sulfate reductase: a 5-methylaminomethyl- (2E)-3,7- AMP CoA a [protein]- a 2-thiouridine jasmonate diphosphomethylpyrimidine -modified tRNA biosynthesis disulfanyl-L-cysteine -sulfanyl-L-cysteine L-cysteine in tRNA UDP-α-D-glucose FabZ: fabZ 3-methyl-2- a 5,10- D-erythrose H153_RS0100535 2-selenouridine 34 dimethylocta- + biosynthesis I selenodiglutathione GTP oxobutanoate methylenetetrahydrofolate 4-phosphate NAD SAH in tRNA 2,6-diene-1-thiol a (2E)-dodec-2-enoyl-[acp] AIR thr adenosylhomocysteinase: sulfite threonylcarbamoyl- bifunctional 3-methyl-2-oxobutanoate H153_RS0102000 phosphomethylpyrimidine AMP synthase: a 5,10- ADP-L-glycero-β- heptosyl- RNase III mRNA α-L-fucosyl-(1->3)- a guanine 527 3,4-dihydroxy- hydroxymethyltransferase: synthase ThiC: thiC a [SoxY protein]-S-(2- a uracil 54 in tRNA menadione NADH H + propanoyl-CoA H O roseoflavin 4-phospho- L-homocysteine H153_RS0101925 methylenetetrahydrofolate D-manno-heptose Kdo -lipid A processing β-D-glucopyranosyl- 2 in 16S rRNA a protein 2-butanone- panB superpathway of tetrahydrofolate biosynthesis HMP-P (L-threonylcarbamoyl) glutathioselenol sulfodisulfanyl)-L-cysteine 2 GTP riboflavin D-erythronate substrate diphosphoundecaprenolcolanic acid 16S rRNA HyaD/HybD family 4-phosphate asp 5-methyltetrahydropteroyltriglutamate- adenylate biosynthesis NAD+ synthase: hydroxymethylpyrimidine/ hydrogen sulfide urea cycle lipopolysaccharide biosynthesis (guanine(527)-N(7) bifunctional hydrogenase a dodecanoyl-[acp] synthase/GTP 2-dehydropantoate - homocysteine S- tRNA (adenosine(37)-N6)- FADH(2)-oxidizing NADH-quinone acyl-CoA protein aspartate 1- H153_RS0104045 phosphomethylpyrimidine heptosyltransferase acetyltransferase )-methyltransferase diguanylate cyclase/ maturation cyclohydrolase II: GTP methyltransferase: metE threonylcarbamoyltransferase methylenetetrahydrofolate- ribonuclease oxidoreductase: thioesterase: RibF: ribF kinase: H153_RS0108030 II: waaF α WcaF: wcaF 7 RsmG: rsmG phosphodiesterase: endopeptidase: H153_RS0107470 decarboxylase: (3R)-3-hydroxy-2-oxo- complex ATPase subunit arg -tRNA-(uracil(54)-C(5) III: rnc H153_RS0107150 [2/3-O-acetyl- -L-fucosyl]- H153_RS09515 an N - roseoflavin ammonium 527 H153_RS0106685 beta-ketoacyl- H153_RS0108190 met hydrogen selenide )- methyltransferase nuoH nuoK (1->3)-β-D-glucopyranosyl- methylguanine H153_RS0100245 2,5-diamino-6-(5-phospho-D- GTP 4 phosphooxybutanoate nicotinate adenine dinucleotide NMN HMP-PP type 1 TsaE: tsaE 5'-phosphate ACP synthase TrmFO: trmFO (heptosyl) - diphosphoundecaprenol in 16S rRNA [+ 4 isozymes] a peptide ribosylamino)pyrimidin-4(3H)-one β cyclohydrolase [+ 2 isozymes] carbamoyl- 2 RNase III c-di-GMP II: fabF -alanine methionine 6 Kdo -lipid A propanoate (R)-pantoate D-glyceraldehyde an N -L- phosphate synthase ADP 2 an mRNA fragment laurate bifunctional I FolE: folE pyruvate thiamine diphosphate argininosuccinate processing + adenosyltransferase: threonylcarbamoyladenine 37 NAD menadiol diaminohydroxyphosphoribosylaminopyrimidine 7,8- 3-phosphate nicotinate (nicotinamide) biosynthesis lyase: argH large subunit: carB a 5-methyluracil 54 product mRNA 4-phosphooxy- H153_RS0102070 in tRNA a tetrahydrofolate a 3-oxotetradecanoyl-[acp] deaminase/5-amino-6-(5-phosphoribosylamino) pantoate--beta- dihydroneopterin nucleotide II (Bacillus) ATP biosynthesis polyphosphate glutamine- in tRNA 1-deoxy-D-xylulose- L-threonine NADP biosynthesis uracil reductase RibD: ribD alanine ligase: 3'-triphosphate adenylyltransferase: SAM metabolism hydrolyzing 5-phosphate 4-hydroxythreonine- HMP-PP 3-oxoacyl-[acyl- 5-amino-6-(5-phospho- H153_RS0105605 nadD thiamine L-arginino-succinate L-ornithine carbamoyl- synthase: 4-phosphate adenine 2503 2-deoxy-D-ribose an N-terminal L- dihomo γ- 966 a supercoiled carrier-protein] lauroyl-CoA NAD + ADP long chain phosphate synthase glutathione H O a guanine histidinol D-ribosylamino)uracil dehydrogenase phosphate isobutanoate hypoglycin A alanyl-[S18 protein 2 reductase: fabG H153_RS0107340 NAD(+)/ NADPH repair (prokaryotes) polyphosphate small subunit: carA in 23S rRNA 5-phosphate linolenoyl-CoA in 16S rRNA GTP duplex DNA 5-amino-6-(5- (R)-pantothenate 7,8- PdxA: pdxA synthase: V-type ATP of 30S ribosome] 16S rRNA replicative NADH kinase: ribosomal protein histidinol a (3R)-3- phosphoribosylamino) dihydroneopterin 1-deoxy-D- 3-amino-1- NaMN nicotinamide thiE synthase: (guanine(966)-N(2) adenylate/guanylate DNA thiamine H153_RS0107355 ornithine carbamoyl phosphate S18-alanine N- dehydrogenase: hydroxytetradecanoyl-[acp] uracil reductase: type III 3'-phosphate xylulose 5- hydroxyacetone nicotinate NADPH H153_RS0102105 23S rRNA acetate--CoA deoxyribose- acyl-CoA )-methyltransferase cyclase domain- helicase: nicotinamidase: phosphate NADP + polyphosphate argininosuccinate carbamoyltransferase: gamma- acetyltransferase: hisD H153_RS0104535 pantothenate phosphate 1-phosphate phosphoribosyltransferase: H153_RS0102120 (adenine(2503)-C(2) ligase: acs phosphate thioesterase: RsmD: rsmD containing protein: dnaB 3-hydroxyacyl- H153_RS0106075 kinase 1: ppk1 synthase: argF glutamyltransferase: an N-terminal N-acetyl-rimI an N 2 - D-ribulose 5-phosphate kinase: H153_RS0105975 thiamine- H153_RS0102125 )-methyltransferase aldolase: H153_RS09515 H153_RS09845 his ACP dehydratase phosphatidylglycerol bifunctional H153_RS0107625 H153_RS0105930 L-alanyl-[S18 protein methylguanine 966 [+ 2 isozymes] H153_RS0104800 pyridoxine 5'- phosphate H153_RS0102130 L-citrulline RlmN: rlmN deoC cyclic-GMP a single FabZ: fabZ biosynthesis II (non-plastidic) bifunctional diaminohydroxyphosphoribosylaminopyrimidine D-erythro-7,8- NAD de novo nicotinate of 30S ribosome] in 16S rRNA (R)-4'- chorismate phosphate kinase: thiL [+ 2 isozymes] di-homo-γ- stranded DNA 3,4-dihydroxy- deaminase/5-amino-6-(5-phosphoribosylamino) dihydroneopterin biosynthesis I phosphoribosyltransferase: ATP long chain isobutanoyl-CoA diphosphate synthase: 2503 AMP a (2E)-tetradec-2-enoyl-[acp] DHAP uracil reductase RibD: ribD phosphopantothenate dihydroneopterin (from aspartate) H153_RS09010 thiamine (R)-NADPHX assimilatory a 2-methyladenine hypoglycin B L-cysteinylglycine D-glyceraldehyde linolenate 2-butanone- aminodeoxychorismate/ H153_RS0102415 bifunctional polyphosphate 5'-deoxyadenosine met acetaldehyde bifunctional aldolase: thiamine diphosphate salvage II diphosphate sulfate reduction III in 23S rRNA 3-phosphate 4-phosphate 5-amino-6-(5-phospho- anthranilate synthase asp ADP-dependent synthase/GTP D-ribitylamino)uracil phosphopantothenoylcysteine H153_RS0103950 component II: NAD(P)H-hydrate sn-glycerol pyridoxine 4-amino-2-methyl-5- cyclohydrolase II: decarboxylase/ 6-(hydroxymethyl) H153_RS0103400 L-aspartate nicotinate dehydratase/ sulfate 3-phosphate 5'-phosphate pyrimidinemethanol H153_RS0107470 phosphopantothenate-- oxidase: nadB sulfate dehypoxanthine a single- 1518 37 -7,8-dihydropterin 4-amino-4- hydroxymethylpyrimidine/ NAD(P)H-hydrate sulfate activation 2-oxobutanoate hydrogen selenide adenine / a [release factor]- guanine a [protein]- a DNA segment cysteine ligase CoaBC: coaBC 2-iminosuccinate SAM O-acetyl-L-serine 1519 Phe a myristoyl-[acp] glycerol-3- 2-amino-4-hydroxy-6- deoxychorismate thiamine diphosphate epimerase: adenylyltransferase: sat futalosine stranded RNA adenine in 16S rRNA L-glutamine in tRNA ATP L-histidine 1-deoxy-L-glycero- (R)-4'- phosphomethylpyrimidine for sulfonation ribosomal RNA peptide chain tRNA phosphate 1-O- ARP hydroxymethyldihydropteridine quinolinate biosynthesis I (E. coli) H153_RS08905 APS tetrulose 4-phosphate biotin biosynthesis from phosphopantothenoyl- kinase: H153_RS0108030 small subunit release factor (guanosine(37)-N1) adenylate/guanylate histidine kinase: recombinase beta-ketoacyl- acyltransferase diphosphokinase: folK synthase (S)-NADPHX polyribonucleotide 8-amino-7-oxononanoate I L-cysteine 5-(2-hydroxyethyl) sulfate phosphoadenylyl- 2-oxoacid:ferredoxin dehypoxanthine cysteine methyltransferase N(5)-glutamine -methyltransferase cyclase domain- H153_RS09275 RecA: recA ACP synthase PlsY: plsY (7,8-dihydropterin- PLP NadA: nadA dipyrromethane HMP-P HMP-PP nucleotidyltransferase: a 1-acyl-sn 6,7-dimethyl-8- bifunctional -4-methylthiazole bifunctional sulfate sulfate reductase: oxidoreductase futalosine synthase A: rsmA methyltransferase: TrmD: trmD containing protein: a [protein]- a DNA segment II: fabF (8S)-8-amino-7- 6-yl)methyl cofactor biosynthesis thiamine N 6 -dimethyladenine 1518 an N 1 - -glycerol 3- ribityllumazine phosphopantothenoylcysteine 4-aminobenzoate adenylyltransferase: sat H153_RS0100535 subunit beta: cyclase: mqnC A: cysK H153_RS0105250 oxononanoate quinolinate hydroxymethylpyrimidine/ ADP-dependent 6 1519 prmC 37 H153_RS09845 N-phospho- in reverse adenosylmethionine- diphosphate phosphate /N -dimethyladenine 5 methylguanine a 3-oxohexadecanoyl-[acp] phosphate synthase: decarboxylase/ an apo-[hydroxymethylbilane NAD(P)H-hydrate APS H153_RS0101035 a [release factor]-N cyclic-AMP L-histidine orientation -8-amino-7- phosphomethylpyrimidine synthase: in 16S rRNA in tRNA Phe 1-acyl-sn-glycerol- H153_RS0100135 phosphopantothenate-- carboxylating synthase]-L-cysteine dehydratase/ sulfite cyclic a single- -methyl-L-glutamine oxononanoate dihydropteroate kinase: H153_RS0108030 4-methyl-5-(2- thiE 5'-deoxyadenosine acetate a nucleoside 3-oxoacyl-[acyl- 3-phosphate cysteine ligase CoaBC: coaBC nicotinate- thiamine NAD(P)H-hydrate adenylyl-sulfate a reduced dehypoxanthine met L-selenocysteine stranded RNA transaminase: bioA synthase: folP phosphooxyethyl) CO propanoyl-CoA H + diphosphate carrier-protein] acyltransferase: (7R,8S)- nucleotide a [hydroxymethylbilane HMP-PP phosphate epimerase: kinase: cysC 2 ferredoxin [iron- futalosine 6,7-dimethyl-8-(1-D-ribityl)lumazine thiazole reductase: fabG H153_RS0106785 diaminononanoate 4'-phosphopantetheine tetrahydrofolate salvage from diphosphorylase: synthase] ES intermediate H153_RS08905 sulfur] cluster 7,8- 2 thiamine- a 1,2-diacyl- 5,10-methenyltetrahydrofolate PAPS a (3R)-3- riboflavin synthase: thioredoxin dihydropteroate nadC hydroxymethylbilane thiamine phosphate hydrogen sulfide sn-glycerol dethiobiotin pantetheine- NADPH hydroxyhexadecanoyl-[acp] H153_RS0104555 synthase: bioD phosphate pathway a 5,10- synthase: hemC phosphate kinase: thiL UDP-N-acetyl- decaprenyl-diphospho-N- a 2,3,4-saturated 1402 an [RNA]-3'- 37 D-ribose 5- 3-phosphate NaMN a proteinogenic leukotriene-C4 a ribonucleoside a single a cytidine a guanine an oxidized DNA with lesion adenylyltransferase: methenyltetrahydrofolate synthase: thiE α-D-glucosamine acetylmuramoyl-pentapeptide 1,2-diacyl-sn- ribonucleoside- phosphate 3-hydroxyacyl- phosphatidate bifunctional a [hydroxymethylbilane thiamine amino acid triphosphate stranded DNA in 16S rRNA in tRNA cytochrome c riboflavin dethiobiotin an oxidized CTP 3 excinuclease ribose 5- ACP dehydratase cytidylyltransferase: coaD methylenetetrahydrofolate nicotinate synthase] ES intermediate diphosphate glycerol 3-phosphate 16S rRNA 2',3'- tRNA cytochrome-c3 thioredoxin 7,8-dihydrofolate 3 FabZ: fabZ H153_RS09765 3'-dephospho- (nicotinamide) undecaprenyldiphospho- (cytidine(1402)-2'-O) cyclophosphate (guanosine(37)-N1) hydrogenase ABC subunit phosphate riboflavin biotin monoglutamate dehydrogenase/ hydroxymethylbilane thiamine phosphate RNA 2',3'-cyclic CoA nucleotide muramoylpentapeptide beta-N- gamma- phosphatidate DNA -methyltransferase: -methyltransferase alpha chain: UvrB: uvrB isomerase a CDP- biosynthesis synthase methenyltetrahydrofolate synthase: hemC Carbohydrate Biosynthesis phosphodiesterase: a (2E)-hexadec-2-enoyl-[acp] adenylyltransferase: acetylglucosaminyltransferase: primase: rsmI 1 TrmD: trmD [+ 2 isozymes] B: rpiB diacylglycerol protein RibF: ribF BioB: bioB dephospho- cyclohydrolase FolD: folD thiamine- Glycolysis glutamyltransferase: cytidylyltransferase: a 2'-O- thpR an N - H153_RS0100965 D-ribulose thioredoxin- an N 10 - murG dnaG an [RNA]-3'- a reduced DNA without CoA kinase: nadD a [hydroxymethylbilane phosphate H153_RS0105930 H153_RS09765 methylcytidine 1402 methylguanine 37 CDP-diacylglycerol-- disulfide formyltetrahydrofolate gluconeogenesis I ribunucleoside- cytochrome c lesion 5-phosphate FMN 9-mercaptodethiobiotin synthase] ES intermediate GDP-mannose biosynthesis 3 glycerol-3-phosphate 3- H153_RS09905 reductase: a 7,8-dihydrofolate nicotinate adenine 4 kinase: thiL UDP-α-D- GDP-L-fucose glycolysis I (from glucose 6-phosphate) Nucleoside and Nucleotide Degradation in 16S rRNA 2'-phosphate in tRNA phosphoribosylglycinamide dinucleotide decaprenyl-pyrophosphoryl- α γ ssDNA/pppN(pN) phosphatidyltransferase: riboflavin biotin trxB hydroxymethylbilane galactose biosynthesis I (from UDP an -( -L-glutamyl) a CDP-2,3,4-saturated- coenzyme A formyltransferase: synthase: hemC thiamine diphosphate (S)-malate D-glucopyranose GDP-D-mannose) D-glucopyranose (N-acetylglucosamine)-N- leukotriene-D4 hybrid pgsA biosynthesis synthase NAD+ synthase: biosynthesis inosine 5'- -L-amino acid diacylglycerol n -1 H153_RS0108515 6-phosphate 6-phosphate guanosine acetylmuramyl-(pentapeptide) a palmitoyl-[acp] 1-(3-sn- protein RibF: ribF BioB: bioB H153_RS0104045 a holo-[hydroxymethylbilane α glucose-6- GDP-α-D-mannose phosphate 5'-deoxyadenosine UDP- -D-glucose nucleotides phosphatidyl) a reduced a tetrahydrofolate synthase] malate UDP-glucose phosphate GDP-mannose glucose-6- degradation degradation I a tetrahydrofolate + degradation III -sn-glycerol FAD biotin thioredoxin NAD dehydrogenase: isomerase: 4,6-dehydratase: 10 1402 37 γ-glutamyl- 4-epimerase phosphate an L-methionyl- an N - a proteinogenic glutathione RNase R degradation pyruvate a cytidine a holo [BryU acyl- adenine 3-sulfopyruvate phosphoenol 3-phosphate mdh H153_RS0108400 gmd 5'-deoxyadenosine val GalE: galE isomerase: IMP Met formyltetrahydrofolate substrate RNA in 16S rRNA in tRNA isopropylamide pyruvate GDP-4-dehydro- [initiator tRNA ] amino acid carrier protein] 1 phosphatidylglycerophosphatase UDP-α-D-galactose F6P α H153_RS0108400 IMP GMP 16S rRNA tRNA1(Val) ferredoxin: sulfopyruvate -D-rhamnose S-methyl-5'- ACP S- pyruvate palmitate A: H153_RS0102750 pyruvate dehydrogenase: 5'/3'- (cytosine(1402)-N(4) (adenine(37)-N6)- H153_RS0100900 decarboxylase oxaloacetate mannose-1-phosphate GDP-L-fucose nucleotidase thioadenosine malonyltransferase: kinase: pyk an L-1- F6P guaB methionyl-tRNA gamma- ribonuclease pyruvate synthase: )-methyltransferase methyltransferase: ferredoxin: subunit Amino Acid Biosynthesis guanylyltransferase/ synthase: SurE: surE phosphorylase: fabD phosphatidyl- XMP formyltransferase: glutamyltransferase: R: rnr H153_RS0100895 4 RsmH: rsmH 6 H153_RS0106015 H153_RS0102025 alpha: comD phosphoenolpyruvate mannose-6- H153_RS0101320 guanosine mtnP an N - a malonyl- an N - N-(γ-L-glutamyl) pyruvate sn-glycerol synthase: ppsA H153_RS0105210 H153_RS0105930 methylcytidine 1402 [BryU acyl- methyladenine 37 sulfoacetaldehyde phosphate isomerase: GDP-4-dehydro-6- class 1 fructose- 5-deoxy-α-D- -L-alaninol L-histidine biosynthesis L-leucine biosynthesis L-threonine deoxy-β-L-galactose 5'/3'- in 16S rRNA carrier protein] in tRNA val palmitoyl-CoA L-lysine biosynthesis I L-arginine biosynthesis II (acetyl cycle) L-tryptophan biosynthesis L-valine biosynthesis L-homoserine H153_RS0101330 bisphosphatase: purine-nucleoside ribose 1-phosphate a nucleoside 5'- 1 phosphoenol nucleotidase an N-formyl- a diribonucleotide acetyl-CoA CO a reduced biosynthesis D-mannopyranose GDP-L-fucose H153_RS0104610 phosphorylase: an α-(γ-L-glutamyl) 2 biosynthesis pyruvate SurE: surE S-methyl-5- a tetrahydrofolate L-cysteinylglycine monophosphate flavodoxin PRPP 3-methyl-2- 6-phosphate synthase: H153_RS0107970 L-methionyl- -L-amino acid asp N-acetylglutamyl-phosphate pyruvate β thioribose-1- [initiator tRNA met ] gln oxobutanoate2-isopropylmalate L-homoserine phosphopyruvate H153_RS0101320 DHAP -D-fructose 1,6- ATP biosynthetic-type asp hydratase: UDP-N-acetyl-D- phosphomannomutase: bisphosphate xanthosine phosphate aspartate kinase: synthase: β guanine phosphoribosyltransferase acetolactate aspartate kinase: homoserine kinase: H153_RS0101385 glucosamine biosynthesis I glmM GDP- -L-fucose isomerase: mtnA H153_RS0105175 anthranilate H153_RS0104770 UDP-N-acetyl-α-D-glucosamine undecaprenyl-diphospho-N 3-aci- (5Z,8Z,11Z,14Z,17Z) a uracil 1498 regulatory subunit: hisZ (2S)-2- synthase: ilvN ilvB H153_RS0105175 H153_RS0102790 D-glucopyranose α-D-mannose triose-phosphate H + hydrogencarbonate a holo [PedN acyl- a holo [BryP acyl- a nitrile N5-CAIR synthase O-phospho- 2-phospho- purine-nucleoside 5-deoxy-D-ribulose -acetylmuramoyl-L-alanyl-γ- nitropropanoate -icosapentaenoyl-CoA in 16S rRNA ATP L-aspartyl-4-phosphate N-acetyl-gamma- isopropylmalate (S)-2-acetolactate L-aspartyl- 6-phosphate 1-phosphate isomerase: carrier protein] carrier protein] component I: trpE L-homoserine D-glycerate glucose-6- phosphorylase: 1-phosphate D-glutamyl-L-lysyl- D-alanine 16S rRNA nitrilase: 5-(carboxyamino) phosphoribosyltransferase: glutamyl-phosphate 3-isopropylmalate 4-phosphate H153_RS0103020 ACP S- ACP S- ketol-acid 2,3-bisphosphoglycerate- phosphate mannose-1-phosphate H153_RS0107970 undecaprenyldiphospho- (uracil(1498)-N(3))- H153_RS0106770 imidazole H153_RS0105395 aspartate- reductase: anthranilate PRPP dehydratase threonine synthase: nitronate carbonic acyl-CoA malonyltransferase: malonyltransferase: reductoisomerase: independent isomerase: guanylyltransferase/ muramoylpentapeptide beta-N- methyltransferase: nitrilase: ribonucleotide semialdehyde acetylglutamate H153_RS0104310 large subunit: leuC aspartate- H153_RS0107715 xanthine xanthine monooxygenase: anhydrase: thioesterase: fabD fabD β ilvC phosphoglycerate H153_RS0108400 mannose-6- D-glyceraldehyde acetylglucosaminyltransferase: 3 H153_RS0100825 H153_RS0104040 mutase: purE 1-(5-phospho- -D-ribosyl)-ATP dehydrogenase: kinase: argB semialdehyde H153_RS09725 H153_RS09330 H153_RS09515 a malonyl[PedN a malonyl- an N - anthranilate 3-isopropylmalate (2R)-2,3-dihydroxy- mutase: F6P phosphate isomerase: 3-phosphate murG 1498 a carboxylate CAIR H153_RS0108650 gln N-acetyl-L-glutamate dehydrogenase: acetaldehyde DHAP acyl-carrier [BryP acyl- methyluracil phosphoribosyl-ATP glu N-acetyl-L-glutamate phosphoribosyltransferase: trpD dehydratase 3-methylbutanoate H153_RS0108650 thr H153_RS0100160 H153_RS0101330 protein] carrier protein] in 16S rRNA L-aspartate 4- bifunctional 5-semialdehyde small subunit: leuD glutamine-- α type I [unspecified (5Z,8Z,11Z,14Z,17Z) diphosphatase: hisE 3-phospho- GDP- -D- ditrans,octacis-undecaprenyldiphospho- UDP 3-oxopropanoate nitrite CO H O coenzyme A carbamoyl- N-acetylornithine dihydroxy-acid L-aspartate 4- glyceraldehyde- degradation 2 2 semialdehyde glutamate N- fructose-6- mannose urate urate N-acetyl-(N-acetylglucosaminyl)muramoyl- -icosapentaenoate phosphate aminotransferase: N-(5-phosphoribosyl)-anthranilate 2-isopropylmaleate dehydratase: ilvD semialdehyde D-glycerate 3-phosphate products] 1-(5-phospho-β-D-ribosyl)-AMP 4-hydroxy- acetyltransferase/ bifunctional phosphate L-alanyl-γ-D-glutamyl-L-lysyl-D-alanine amino-acid synthase large hemL homoserine phosphoglycerate transaminase dehydrogenase: tetrahydrodipicolinate glutamate N- phosphoribosylanthranilate 3-isopropylmalate 3-methyl-2-oxobutanoate purine ribonucleosides degradation phosphoribosyl-AMP acetyltransferase subunit: carB acetyltransferase/ dehydrogenase: kinase: pgk (isomerizing) gap synthase: isomerase: H153_RS0103030 dehydratase UDP-N-acetyl-α-D-glucosamine undecaprenyl-diphospho-N-acetylmuramoyl-L- 5-amino-4- an (R)-2- an (S)-2- a uridine 13 (indol-3-yl) a [protein]- cyclohydrolase: hisI ArgJ: argJ glutamine- amino-acid H153_RS0100840 : glmS a holo [PedD acyl- π H153_RS0107710 large subunit: leuC branched-chain β alanyl-γ-D-glutamyl-L-lysyl- D-alanyl-D-alanine imidazolecarboxyamide PRPP halocarboxylate halocarboxylate in tRNA acetonitrile Ins(1)P N -phospho- β (2S,4S)-4- hydrolyzing acetyltransferase 1-(2-carboxyphenylamino)-1- 13-DPG dTDP- -L-rhamnose 13-DPG carrier protein] 1-(5-phospho- -D-ribosyl)- 3-isopropylmalate amino acid L-glutamate D-glucosamine adenosine tRNA nitrilase: L-histidine hydroxy-2,3,4,5- carbamoyl- ArgJ: argJ deoxy-D-ribulose 5-phosphate L-homoserine biosynthesis undecaprenyldiphospho- inositol phosphohistidine 5-[(5-phosphoribosylamino) dehydratase transaminase: biosynthesis III 6-phosphate ACP S- pseudouridine(13) H153_RS0106770 methylideneamino]imidazole- tetrahydrodipicolinate phosphate L-isoleucine indole-3-glycerol H153_RS0104035 type I α-D-glucopyranose muramoylpentapeptide beta-N- adenine HAD family HAD family malonyltransferase: monophosphatase: phosphatase N-acetyl-L-ornithine biosynthesis II small subunit: leuD glyceraldehyde- phosphoglucosamine synthase TruD: truD nitrilase: 4-carboxamide 4-hydroxy- synthase small phosphate 2-oxoglutarate 1-phosphate phosphoglycerate acetylglucosaminyltransferase: phosphoribosyltransferase: hydrolase: hydrolase: fabD H153_RS0102835 SixA: sixA (2R,3S)-3- 3-phosphate mutase: glmM glucose-1-phosphate a malonyl- [+ 2 isozymes] H153_RS0104040 1-(5-phosphoribosyl)-5- tetrahydrodipicolinate subunit: carA synthase TrpC: trpC val glutamate synthase kinase: pgk murG H153_RS0100625 H153_RS09735 H153_RS09735 a pseudouridine 13 a [protein]- pyruvate isopropylmalate triose-phosphate dehydrogenase: α-D-glucosamine thymidylyltransferase [PedD acyl- (indol-3-yl)acetate myo-inositol [(5- phosphoribosylamino) reductase: (1S,2R)-1-C-(indol-3- L-proline large subunit: gltB in tRNA L-histidine carbamoyl phosphate L-ornithine citramalate 3-isopropylmalate isomerase: gap 1-phosphate RfbA: rfbA carrier protein] methylideneamino]imidazole-4- H153_RS0107700 synthase: yl)glycerol 3-phosphate biosynthesis I NADPH-dependent dTDP-α-D-glucose 3-phospho- ditrans,octacis-undecaprenyldiphospho-N- UDP an (S)-2- a (2R)-2- dehydrogenase: (from L-glutamate) L-cysteine biosynthesis I H153_RS0103020 D-glyceraldehyde UDP-N- xanthosine adenosine inosine guanosine β AICAR a halide anion a halide anion carboxamide isomerase: hisA (S)-2,3,4,5- cimA tryptophan synthase glutamate DHAP D-glycerate acetyl-(N-acetyl- -D-glucosaminyl)muramoyl-L- hydroxycarboxylate hydroxy fatty acid leuB 3-phosphate acetylglucosamine dTDP-glucose 4,6- γ phosphoribulosylformimino- tetrahydrodipicolinate (R)-citramalate subunit alpha: synthase: gltA alanyl- -D-glutamyl-L-lysyl-D-alanyl-D-alanine (2S)-2-isopropyl- glu diphosphorylase/ dehydratase: rfbB 2,3-bisphosphoglycerate- AICAR-phosphate 2,3,4,5- H153_RS0105850 ser glu 3-oxosuccinate glutamate 5- glucosamine-1- dTDP-4-dehydro-6- independent purine-nucleoside purine-nucleoside purine-nucleoside purine-nucleoside tetrahydropyridine- tryptophan synthase phosphate N- deoxy-α-D-glucopyranose phosphorylase: phosphorylase: phosphorylase: phosphorylase: an (S)-2- an (R)-2- 2-hydroxy-2- a [protein]-L- a [protein]- kinase: proB serine O- phosphoglycerate dethiobiotin a sulfurated glycyl-glycine glutathione [DNA] Ins(2)P τ imidazole glycerol 2,6-dicarboxylate N- ornithine subunit beta: trpB γ-L-glutamyl acetyltransferase: dTDP-4- H153_RS0107970 H153_RS0107970 H153_RS0107970 H153_RS0107970 SAM halocarboxylate halocarboxylate methylpropanenitrile proline (ω = 180) N -phospho- succinyltransferase: acetyltransferase: mutase: [sulfur carrier] DNA polymerase/ nitrilase: peptidylprolyl L-histidine phosphate synthase carbamoyltransferase: 5-phosphate glmU dehydrorhamnose inositol H153_RS0101190 citraconate indole ser cysE H153_RS0100160 3'-5' exonuclease H153_RS0106770 isomerase: phosphohistidine subunit HisH: hisH argF 4-methyl-2- α 3,5-epimerase: rfbC α-D-ribose- monophosphatase: glutamate-5- alanine N-acetyl- -D- biotin gamma- HAD family HAD family PolX: polX H153_RS0107600 phosphatase imidazole glycerol N-succinyl-2-amino- oxopentanoate β-D-fructose 1,6- dTDP-4-dehydro- 1-phosphate nitrilase: H153_RS0102835 semialdehyde O-acetyl-L-serine racemization glucosamine 2-phospho- synthase glutamyltransferase: hydrolase: hydrolase: SixA: sixA phosphate synthase 6-ketopimelate tryptophan synthase branched-chain hydrogen sulfide bisphosphate β-L-rhamnose UTP and CTP dephosphorylation I pyrimidine deoxyribonucleosides degradation [+ 2 isozymes] H153_RS0104040 [+ 2 isozymes] dehydrogenase: 1-phosphate D-glycerate BioB: bioB H153_RS0105930 H153_RS09735 H153_RS09735 a 2'-deoxyribonucleoside 2-hydroxy-2- a [protein]-L- myo-inositol a [protein]- subunit HisF: hisF succinyldiaminopimelate subunit alpha: amino acid H153_RS0104365 class 1 fructose- UDP-N- dTDP-4- methylpropanoate proline (ω = 0) L-histidine (2R,3S)-3- ala phosphopyruvate UTP 2'-deoxycytidine 5'-monophosphate transaminase: dapC H153_RS0105850 transaminase: cysteine bisphosphatase: acetylglucosamine dehydrorhamnose γ methylmalate L-glutamate-5- alanine hydratase: D-ribose 5- -L-glutamyl- an (S)-2- a (2R)-2- D-erythro-1-(imidazol-4- tryptophan synthase H153_RS0104035 synthase A: cysK H153_RS0104610 diphosphorylase/ reductase: rfbD biotin 5'-deoxyadenosine met an unsulfurated L-cysteinylglycine a halide anion a halide anion AICAR N-succinyl-L,L-2,6- L-citrulline semialdehyde racemase: H153_RS0101385 CTP synthase: phosphate nucleoside [sulfur carrier] glycylglycine hydroxycarboxylate hydroxy fatty acid yl)-glycerol 3-phosphate subunit beta: trpB glucosamine-1- β diaminopimelate leu alr F6P dTDP- -L-rhamnose H153_RS0101950 deaminase: imidazoleglycerol- argininosuccinate phosphate N- succinyl- cys D-ala PRPP biosynthesis phosphoenol UDP H153_RS0107675 thymidine phosphate synthase: acetyltransferase: β diaminopimelate 2-oxobutanoate trp glucose-6- pyruvate CTP cytidine 3-methyl-2- 5,10-methylene- D-glyceraldehyde D-sedoheptulose D-threo-7,8- (3E,5Z)-tetradeca- an insertion sequence 2-amino-3,7- ADP-D-glycero- - a [protein]- dehydratase H153_RS0107625 glmU D-ribose 5- thymidine 3-phenylpropionitrile desuccinylase: (S)-1-pyrroline- phosphate deaminase: oxobutanoate tetrahydromethanopterin 3-phosphate 7-phosphate dihydroneopterin 3,5-dienoyl-CoA element IS30 dideoxy-D-threo- D-manno-heptose N-phospho- HisB: hisB dapE biosynthetic- 5-carboxylate isomerase: UDP-N-acetyl- phosphate phosphorylase: nitrilase: hept-6-ulosonate ADP- L-histidine L-arginino-succinate α ribose-phosphate phosphoenolpyruvate pyruvate cdd transposase: type pyrroline-5- H153_RS0108400 -D-glucosamine UMP H153_RS0107295 H153_RS0104040 3-dehydroquinate glyceromanno- phosphohistidine 3-(imidazol-4-yl)-2- L-selenocysteine pyrophosphokinase: prs synthase: ppsA kinase: pyk 3-methyl-2-oxobutanoate dihydroneopterin acyl-CoA H153_RS0103685 L,L-diaminopimelate acetolactate carboxylate D-glucopyranose CDP transketolase: nitrilase: synthase II: heptose 6- phosphatase oxopropyl phosphate argininosuccinate biosynthesis I (bacteria) PRPP 5'/3'- 2'-deoxyuridine thymine hydroxymethyltransferase: aldolase: thioesterase: [+ 3 isozymes] synthase: reductase: 6-phosphate H153_RS0103340 an insertion H153_RS0106770 H153_RS0105680 epimerase: rfaD SixA: sixA histidinol-phosphate lyase: argH ilvN ilvB nucleotidase panB H153_RS0103950 H153_RS09515 ADP-L-glycero-β- a [protein]- diaminopimelate proC ammonia assimilation cycle III pyruvate sequence IS30 with 3-phenylpropanoate 3-dehydroquinate transaminase: sec SurE: surE D-manno-heptose epimerase: (S)-2-aceto-2- ser a tRNA integrated transposon L-histidine H153_RS0102005 arg CMP H153_RS0108145 L-tyrosine hydroxybutanoate pro NADH repair (prokaryotes) uridine D-ribose 5- D-xylulose 6-(hydroxymethyl) (3E,5Z)- ammonium 2-dehydropantoate THMPT phosphate 5-phosphate glycolaldehyde coenzyme A biosynthesis I L-phenylalanine selenide 5'/3'- -7,8-dihydropterin tetradecadienoate L-histidinol phosphate meso-diaminopimelate serine- glutamate biosynthesis I glu NADH nucleotidase chorismate -tRNA selenide, synthase glycine biosynthesis I Chemoautotrophic SurE: surE histidinol phosphate diaminopimelate large type I uracil 2-deoxy-α-D- chorismate (R)-2,3-dihydroxy- ligase: water Energy Metabolism CoB-CoM a single a cytosine 967 D-arabinofuranose β-D-glucose a double phosphatase domain- decarboxylase: chorismate 2-oxoglutaratesubunit: gltB glutamate- cytidine ribose 1-phosphate dihydromethanophenazine seleno-L- F6P a ribonucleoside mutase: pheA 3-methylpentanoate serS dikinase heterodisulfide stranded DNA in 16S rRNA 5-phosphate 6-phosphate stranded DNA 5'-monophosphate containing protein: H153_RS0103295 chorismate -ammonia hydrogen oxidation homocysteine prephenate dihydroxy-acid SelD: selD NADPH- ser 16S rRNA 3-deoxy-8- inositol-3-phosphate DNA/RNA 5'/3'- H153_RS0104000 mutase: pheA ligase: glnA serine I (aerobic) 5-methyltetrahydropteroyltriglutamate- deoxyribonuclease diaminopimelate dehydratase: an L-seryl- dependent pyrimidine deoxyribonucleotides (cytosine(967)-C(5) phosphooctulonate synthase: nuclease nucleotidase prephenate selenophosphate hydroxymethyltransferase: (R)-NADHX heterodisulfide - homocysteine S- fructose-6- IV: H153_RS0108730 histidinol decarboxylase: lysA prephenate ilvD [tRNA sec ] glutamate dephosphorylation )-methyltransferase synthase: kdsA H153_RS0108545 SfsA: sfsA imidazole H bifunctional reductase subunit B: methyltransferase: metE phosphate SurE: surE dehydrogenase: synthase: gltA H153_RS0104720 2 RsmB: rsmB prephenate (3S)-3-methyl-2- glycerol nucleoside triphosphate 967 lys gly Ni/Fe-hydrogenase, ADP-dependent H153_RS0102305 aldolase: fsa a 5'-phosphooligonucleotide a 5-methylcytosine KDO-8P Ins(3)P a 5'-phosphooligonucleotide a ribonucleoside histidinol H153_RS0100680 dehydratase: oxopentanoate phosphate pyrophosphohydrolase: SeMet 3-(4- L-seryl-tRNA(Sec) b-type cytochrome: NAD(P)H-hydrate in 16S rRNA dehydrogenase: hisD pheA ammonium synthase gln mazG hydroxyphenyl) branched-chain selenium H153_RS0100230 cybH dehydratase/ D-glyceraldehyde subunit dCTP dCMP coenzyme M coenzyme B methanophenazine dihydroxyacetone histidinal pyruvate 3-phenyl-2- amino acid transferase: A(H2) NAD(P)H-hydrate 3-phosphate oxopropanoate transaminase: H153_RS0102460 HisF: hisF epimerase: nucleoside triphosphate histidinol H153_RS0104035 [+ 9 isozymes] H153_RS08905 an L- (S)-NADHX pyrophosphohydrolase: dehydrogenase: hisD UDP-N-acetyl-α-D-muramoyl- 2-amino-6-[1-hydroxyethyl]- D-xylulose D-erythrose 3-phospho- (S)-2-aceto-2- (2R,3S)-3- a negatively selenocysteinyl- mazG D-alanyl-D-alanine uroporphyrinogen-III an acyl phosphate ile bifunctional dUTP dUMP L-alanyl-γ-D-glutamyl-L-lysine 7-methyl-7,8-dihydropterin 5-phosphate 4-phosphate D-glycerate hydroxybutanoate isopropylmalate supercoiled DNA tyr [tRNA sec ] his phe glu ADP-dependent 2-amino-4-hydroxy-6- phosphoglycerate ketol-acid 3-isopropylmalate type I DNA uroporphyrinogen acylphosphatase: NAD(P)H-hydrate hydroxymethyldihydropteridine dehydrogenase: reductoisomerase: dehydrogenase: topoisomerase: UDP-N-acetylmuramoyl- transketolase: decarboxylase: hemE H153_RS0108670 dehydratase/ 5-hydroxy-CTP 5-hydroxy-CMP diphosphokinase: folK H153_RS0106835 ilvC leuB topA tripeptide--D-alanyl-D- [1-(2-amino-7-methyl-4-oxo- H153_RS0103340 NAD(P)H-hydrate (R)-2,3-dihydroxy- 4-methyl-2- alanine ligase: murF 7,8-dihydro-3H-pteridin- coproporphyrinogen III 3-phosphooxypyruvate a carboxylate a relaxed DNA epimerase: 3-methylpentanoate oxopentanoate purine deoxyribonucleosides degradation I 6-yl)]ethyl diphosphate H153_RS08905 α D-glyceraldehyde UDP-N-acetyl- -D-muramoyl-L-alanyl- F6P γ-D-glutamyl-L-lysyl-D-alanyl-D-alanine 3-phosphate NADH S-methyl-5'- thioadenosine 2'-deoxyinosine 2'-deoxyadenosine 2'-deoxyguanosine degradation II 2,5-diamino-6-(5- an [amino-group carrier protein]- a uridine 55 adenosyl-cob(III) D-ribulose a uridine 38-40 in tRNA γ uroporphyrinogen-I citrate hydroxylamine S-methyl-5'- phospho-D-ribitylamino) C-terminal- -(L-glutamate 5- in tRNA yrinate a,c-diamide 5-phosphate pyrimidin-4(3H)-one RluA family pseudouridine semialdehyde-2-yl)-L-glutamate thioadenosineS-methyl-5'- purine-nucleoside purine-nucleoside purine-nucleoside bifunctional N-acetyl-gamma- tRNA cobyric acid ribulose-phosphate hydroxylamine phosphorylase: phosphorylase: phosphorylase: synthase: H153_RS0103115 glutamyl-phosphate uroporphyrinogen aconitate hydratase: pseudouridine(55) synthase CobQ: 3-epimerase: oxidase: thioadenosine diaminohydroxyphosphoribosylaminopyrimidine decarboxylase: hemE H153_RS0101165 phosphorylase: H153_RS0107970 H153_RS0107970 H153_RS0107970 deaminase/5-amino-6-(5-phosphoribosylamino) tRNA pseudouridine(38- reductase: synthase TruB: truB H153_RS0107125 H153_RS0104710 H153_RS09430 mtnP uracil reductase RibD: ribD 40) synthase TruA: truA an [amino-group carrierH153_RS0104310 protein]- a pseudouridine 55 D-xylulose 2-deoxy-α-D- 5-amino-6-(5-phospho- 38-40 coproporphyrinogen I D-threo-isocitrate adenosylcobyrate nitrite 5-MTR-1-P a pseudouridine in tRNA C-terminal-γ-(5-phospho- in tRNA 5-phosphate ribose 1-phosphate D-ribitylamino)uracil L-glutamyl)-L-glutamate

a (6S)-5- cytidine D-sedoheptulose phosphatidylglycerolphosphate a pseudouridine 1915 in 23S rRNA protoporphyrinogen IX a double stranded DNA GDP-β-L-fucose NADH (1-oleoyl, 2-palmitoyl) formyltetrahydrofolate nucleoside deaminase: 7-phosphate 23S rRNA 5-formyltetrahydrofolate H153_RS0107675 D-sedoheptulose DNA gyrase GDP-L-fucose NAD(+)/ phosphatidylglycerophosphatase (pseudouridine(1915)- protoporphyrinogen synthase: cyclo-ligase: cytidine deaminase: cdd 7-phosphate subunit A: gyrA NADH kinase: A: H153_RS0102750 N(3))-methyltransferase H153_RS0104080 oxidase: hemG isomerase: gmhA H153_RS0101320 H153_RS0107355 uridine [+ 2 isozymes] RlmH: H153_RS0107065 a 5,10- D-glycero-D-manno- a negatively GDP-4-dehydro- 1-oleoyl-2-palmitoyl- an N 3 -methylpseudouridine 1915 α protoporphyrin IX heptose 7-phosphate -D-rhamnose NADPH phosphatidylglycerol in 23S rRNA methenyltetrahydrofolate supercoiled DNA

ammonium ammonium

Amt Amt

ammonium ammonium

This diagram was automatically generated by SRI International Pathway Tools version 25.0, authors S. Paley and P.D. Karp.