DOCSLIB.ORG

What to Expect for Your First Visit for Skin Testing

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
What to Expect for Your First Visit for Skin Testing What to expect for your first visit for Skin Testing • Please arrive 15 minutes prior to your appointment. • Wear comfortable non-restrictive clothing. Shorts sleeve or sleeveless shirts are best. • Bring your New Patient packet of information given to you on the day of your evaluation with Dr. Connor. • Bring an antihistamine with you the day of testing (ex: Zyrtec, Claritin, Allegra) for use after testing if needed. • Bring your asthma inhaler with you if you have asthma. • Patients under the age of 18 will need to be accompanied by an adult. • Allow at least one hour for skin prick testing. If additional testing is needed or if you see the physician, this will lengthen your visit possibly by another hour. • Avoid any strenuous activity 2 hours before and for 2 hours after testing. • Please visit our Tallahassee ENT YouTube webpage to watch a video on our Allergy program Y004-3 July 2020 Contra-Indicated Medications Medicines that affect allergy skin testing: Do not take these medications 7 days (or as listed below), prior to your appointment: *This is not an all-inclusive list, review all the ingredients on the package or ask your doctor or pharmacist.* Antihistamines - First Generation Generic Name Brand Names Azatadine Optimine Bromphenarimine BroveX, Dimetane, Lodrane Carbinoxamine Maleate Histex Pd, Palgic and Pediatex Chlorpheniramine AHIST, Aller-Chlor, C.P.M, Chlo-Amine, Chlor-Allergy, Chlor-Mal, ChlorTrimeton, Chlorphen, Effidac-24, Histex, Ridraman Clemastine (10 days) Allerhist-1, Contact 12hr Allergy, Tavist-1 Cyproheptadine (11 days) Periactin Dexchlorpheniramine Polaramine Diphenhydramine Actifed Sinus Day, Aler-Tab, Allergy, AllergySinus, Allermax, Aler-Dryl, Altaryl, Banophren, Benadryl, Calm-Aid, Children's Allergy, Compoz Nighttime, Diphedryl, Diphen-Allergy, Diphenhist, Dormin Sleep Aide, Dytan, Dytuss, Genahist, Hydramine, Ibuprofen PM, Nu-Med, Nytol, PediaCare Children's Allergy, Q-Dryl, Quenalin, Scot-Tussin Allergy, Siladryl, Silphen, Simply Allergy, Simply Sleep, Sleep-ettes, Sleep Formula, Sleepinal, Sominex, Tavist, Theraflu, Triaminic, Twilite, Tylenol PM, Unisom Sleep Gels, Valu-Dryl Dimenhydrinate Dramamine Hydroxyzine (8 days) Atarax, Rezine, Vistaril Ketotifen Zatiden Meclizine HCl Antivert, Bonine Methdilazine Tacaryl Phenindamine Nolahist Promethazine Chlorpromazine, Phenergan, Promethazine, Prorex 25 & 50, Thorazine Pryilamine Nisaval Trimaparazine Tremaril Tripelennamine PBZ & PBZ-SR Triprolidine Myidyl, Zymine Antihistamines - Second Generation Astemizole Hismanal Cetirizine Zyrtec Desloratidine Clarinex Fexofenadine Allegra Loratadine (9 days) Alavert, Claritin Antihistamines - Second Generation - continued Levocetirizine dihyrochloride Xyzal Metquitazine Primalan, Quintadrill Mizolastine Mizollen, Mistamine Terfenadine Seldane Antihistamine Nose Sprays - 2 days Azelastine Astelin, Astepro, Patanase, Dymista Antihistamine Eye Drops (Ophthalmic) - 2 days Azelastine Optivar Olopatadine Patanase, Pataday and Patanol Opthalmic eye drops Other Theophylline Theo-Dur, Respbid, Slo-Bid, Theo-24, Theolair, Uniphyl, Slo-Phyllin Vitamins A,C,D and E In doses >1000u Ranitidine (2 days) Zantac *Do not stop taking your Asthma medications!* For questions: Please call 850-877-0101 Y004-3 July 2020 *You must have approval to stop taking any Betablocker medication from the doctor that prescribed it. That doctor may want to prescribe a replacement medication for you to take for the 5 days before your testing* *This list is not all inclusive. Check with your doctor or pharmacist if your medication contains a betablocker* Beta Adrenergic Blocking Agents – Betablockers (5 days) Anaphylaxis may be more difficult to treat Acebutolol -(B1 selective) Sectral Capsules Atenolol -(B1 selective) Tenoretic 50 & 100, Tenormin Betaxolol - (B1 selective) Betoptic & S ( Opthalmic / eye drops ), Kerlone Bisoprolol -(B1 selective) Zebeta, Ziac Carteolol (NS) Cartrol Filmtab Tabs, Ocupress (Opthalmic / eye drops) Carvedilol (NS) Coreg Esmolol HCL (NS) Brevibloc Injection Labetalol (NS) Normodyne, Trandate Levobunolol AK-Beta, Betagan Liquifilm(Opthalmic / eye drops) Levobetaxolol Betaxon Metipranolol OptiPranolol (Opthalmic / eye drops) Metoprolol -(B1 selective) Lopressor + Lopressor HCT, Toprol-XL Nadolol (NS) Corgard, Corzide, Nadolol Tabs Penbutolol (NS) Levatol Pindolol (NS) Visken Pindolol (NS) Inderal, Inderide Sotalol - (B1 selective) Betapace, Sorine Timolol + Timolol Maleate (NS) Betimol, Blocarden, Ocumeter, Timolide tabs, Cosopt, Occudose, Timoptic, XE, (Opthal / eye drops) Tricyclic Antidepressants (14 days) You must OK stopping these with the doctor who prescribed them. Amitriptyline Elavil, Endep, Etrafon, Limbitrol, Vanatrip Amoxampine Asendin Clomipramine Anaframil Desipramine Norpramin Doxepin Adapin, Sinequan (8 days), Zonalon (+topical) (14 days) Imipramine Tofranil Nortriptyline Aventyl HCL, Pamelor Protriptyline Vivactil Trimipramine Surmontil Benzodiazepines (7days) Atypical Antidepressants/Sedatives (5 days) Clonazepam Klonopin Bupropion Wellbutrin Diazepam Valium Eszopiclone Lunesta Lorazepam Ativan Mirtazapine (7 days) Remeron Midazolam Versed Quetiapine (7 days) Seroquel Trazodone Oleptro Zolpidem Ambien Herbal Supplements: Do not take 7 days before allergy testing: Decrease test results: Licorice, Green Tea, Saw Palmetto, St. John’s Wort, Feverfew Increase test results: Milk Thistle, Astragalus Medicines you CAN take before allergy testing: Nasal sprays Afrin Mometasone Oxymetazoline Beclamethasone Nasacort Rinocort Beconase Nasalcrom QNasal Budesonide Nasaril Trimacinalone Flonase Nasonex Veramyst Flunisolide Neosynephrine Eye drops Acular Alamast Alocril Alomide Proton Pump Inhibitors (PPI) Dexlansoprazole Omeprazole Kapidex Prilosec, Zegerid Esomeprazole Pantoprazole Nexium Protonix Lansoprazole Rabeprazole Prevacid Aciphex Serotonin Norepinephrine Reuptake Inhibitors (SNRI) Selective Serotonin Reuptake Inhibitors (SSRI) Duloxetine Citalopram Celexa Desvenlafaxine Escitalopram Lexapro Milnacipran Ixen,Savella Fluoxetine Prozac Venlafaxine Olanzapine + Fluoxetine Symbyax Paroxetine Paxil Sertraline Zoloft Other Antibiotics Phenylephrine Singulair Guaifenesin / Mucinex Pseudoephedrine / Sudafed Y004-3 July 2020 .
Load more

Recommended publications
  • Intranasal Rhinitis Agents
    Intranasal Rhinitis Agents Therapeutic Class Review (TCR) February 1, 2020 No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, digital scanning, or via any information storage or retrieval system without the express written consent of Magellan Rx Management. All requests for permission should be mailed to: Magellan Rx Management Attention: Legal Department 6950 Columbia Gateway Drive Columbia, Maryland 21046 The materials contained herein represent the opinions of the collective authors and editors and should not be construed to be the official representation of any professional organization or group, any state Pharmacy and Therapeutics committee, any state Medicaid Agency, or any other clinical committee. This material is not intended to be relied upon as medical advice for specific medical cases and nothing contained herein should be relied upon by any patient, medical professional or layperson seeking information about a specific course of treatment for a specific medical condition. All readers of this material are responsible for independently obtaining medical advice and guidance from their own physician and/or other medical professional in regard to the best course of treatment for their specific medical condition. This publication, inclusive of all forms contained herein, is intended to be educational in nature and is intended to be used for informational purposes only. Send comments and suggestions to [email protected].
    [Show full text]
  • MSM Cross Reference Antihistamine Decongestant 20100701 Final Posted
    MISSISSIPPI DIVISION OF MEDICAID Antihistamine/Decongestant Product and Active Ingredient Cross-Reference List The agents listed below are the antihistamine/decongestant drug products listed in the Mississippi Medicaid Preferred Drug List (PDL). This is a cross-reference between the drug product name and its active ingredients to reference the antihistamine/decongestant portion of the PDL. For more information concerning the PDL, including non- preferred agents, the OTC formulary, and other specifics, please visit our website at www.medicaid.ms.gov. List Effective 07/16/10 Therapeutic Class Active Ingredients Preferred Non-Preferred ANTIHISTAMINES - 1ST GENERATION BROMPHENIRAMINE MALEATE BPM BROMAX BROMPHENIRAMINE MALEATE J-TAN PD BROMSPIRO LODRANE 24 LOHIST 12HR VAZOL BROMPHENIRAMINE TANNATE BROMPHENIRAMINE TANNATE J-TAN P-TEX BROMPHENIRAMINE/DIPHENHYDRAM ALA-HIST CARBINOXAMINE MALEATE CARBINOXAMINE MALEATE PALGIC CHLORPHENIRAMINE MALEATE CHLORPHENIRAMINE MALEATE CPM 12 CHLORPHENIRAMINE TANNATE ED CHLORPED ED-CHLOR-TAN MYCI CHLOR-TAN MYCI CHLORPED PEDIAPHYL TANAHIST-PD CLEMASTINE FUMARATE CLEMASTINE FUMARATE CYPROHEPTADINE HCL CYPROHEPTADINE HCL DEXCHLORPHENIRAMINE MALEATE DEXCHLORPHENIRAMINE MALEATE DIPHENHYDRAMINE HCL ALLERGY MEDICINE ALLERGY RELIEF BANOPHEN BENADRYL BENADRYL ALLERGY CHILDREN'S ALLERGY CHILDREN'S COLD & ALLERGY COMPLETE ALLERGY DIPHEDRYL DIPHENDRYL DIPHENHIST DIPHENHYDRAMINE HCL DYTUSS GENAHIST HYDRAMINE MEDI-PHEDRYL PHARBEDRYL Q-DRYL QUENALIN SILADRYL SILPHEN DIPHENHYDRAMINE TANNATE DIPHENMAX DOXYLAMINE SUCCINATE
    [Show full text]
  • Allergy Testing and History Form
    Skin Testing Information and Consent 1. Skin Testing An allergy skin test is used to identify the substances that are causing your allergy symptoms. We will apply several extracts of common allergens to the skin and observe for a reaction. The reactions are then graded and confirmatory intradermal testing may be performed. This involves placing a small amount of extract under the skin of the upper arm. We then observe the reaction and record the results. On the day of testing please wear a short-sleeved shirt that can be pushed up comfortably to your shoulder. Allow 1-2 hours for your test session. You will need to stay on the premises during this time. Please do not bring children to your appointment. 2. Risks of Skin Testing Bleeding and infection may occur due to abrading of the skin. Any time the skin integrity is broken it puts on at risk for infection. However, this is a rare occurrence. The antigens used for testing are sterile and approved by the FDA. Occasionally, skin testing can trigger a severe allergic reaction requiring treatment with medications and/or treatment in the ER. Patients with asthma are at increased risk for triggering an asthma attack during testing. You should not undergo testing if you feel that you have allergy or asthma symptoms are currently under poor control. 3. Contraindications to Skin Testing Women who are pregnant or anyone who is currently taking Beta-Blockers, Tricyclic Anti-depressants or MAOI’s medications will NOT be skin tested. Please be sure to inform us of ALL your medications before the skin test is applied.
    [Show full text]
  • 2-Bromopyridine Safety Data Sheet Jubilant Ingrevia Limited
    2-Bromopyridine Safety Data Sheet According to the federal final rule of hazard communication revised on 2012 (HazCom 2012) Date of Compilation : July 03 ’ 2019 Date of Revision : February 09 ’ 2021 Revision due date : January 2024 Revision Number : 01 Version Name : 0034Gj Ghs01 Div.3 sds 2-Bromopyridine Supersedes date : July 03 ’ 2019 Supersedes version : 0034Gj Ghs00 Div.3 sds 2-Bromopyridine Jubilant Ingrevia Limited Page 1 of 9 2-Bromopyridine Safety Data Sheet According to the federal final rule of hazard communication revised on 2012 (HazCom 2012) SECTION 1: IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING 1.1. Product identifier PRODUCT NAME : 2-Bromopyridine CAS RN : 109-04-6 EC# : 203-641-6 SYNONYMS : 2-Pyridyl bromide, Pyridine, 2-bromo-, beta-Bromopyridine, o-Bromopyridine SYSTEMATIC NAME : 2-Bromopyridine, -Pyridine, 2-bromo- MOLECULAR FORMULA : C5H4BrN STRUCTURAL FORMULA N Br 1.2. Relevant identified uses of the substance or mixture and uses advised against 1.2.1. Relevant identified uses 2-Bromopyridine is used as an intermediate in the pharmaceutical industry for the manufacture of Atazanavir (an antiretroviral drug), Carbinoxamine, Chloropyramine, triprolidine (antihistamine drugs), Disopyramide Phosphate (an antiarrythmic drug), Mefloquine (antimalarial drug), Pipradrol (mild CNS stimulant) etc. Uses advised against: None 1.3. Details of the supplier of the safety data sheet Jubilant Ingrevia Limited REGISTERED & FACTORY OFFICE: Jubilant Ingrevia Limited Bhartiagram, Gajraula , District: Amroha, Uttar Pradesh-244223, India PHONE NO: +91-5924-252353 to 252360 Contact Department-Safety: Ext. 7424 , FAX NO : +91-5924-252352 HEAD OFFICE: Jubilant Ingrevia Limited, Plot 1-A, Sector 16-A,Institutional Area, Noida, Uttar Pradesh, 201301 - India T +91-120-4361000 - F +91-120-4234881 / 84 / 85 / 87 / 95 / 96 [email protected] -www.jubilantingrevia.com 1.4.
    [Show full text]
  • Download Article (PDF)
    Use of astemizole in a large group practice TIMOTHY J. CRAIG, DO MARK GREENWALD, MD VANESSA KAUFFMANN JILL CRAIG, MS Astemizole was released in 1988. Shortly after the release of astemizole and terfe­ In late 1992, a new warning label was added nadine, it became evident that both were associat­ in response to reports of syncope and death ed with prolonged QT intervals and arrhythmias, from arrhythmia. Records of patients given new mainly torsades de pointes. Because of this associ­ prescriptions for astemizole were reviewed ation, the Food and Drug Administration (FDA) and to assess compliance with the warnings in a the manufacturers provided a warning letter to large multispecialty practice. The indication physicians in 1992.1 For astemizole, the warning was appropriate in 89% of cases. Excessive stated: (1) That arrhythmias have usually occurred doses were used in 4% of cases. Two percent when the dose of 10 mg/d (the recommended dose) of prescriptions were given to patients with was exceeded. Exceeding this dose and the use of contraindications. Only two complications loading doses should be avoided. (2) Serum levels were documented. Despite carrying a drug of astemizole may be elevated by ketoconazole, ery­ warning, astemizole continues to be used thromycin;, and itraconazole. These drugs should inappropriately and is a medicolegal concern. not be used together. (3) Presyncope and syncope Education and drug evaluations can be used may precede fatal arrhythmias and calls for dis­ to enhance compliance and decrease the risk continuing astemizole. (4) The drug should be avoid­ associated with the use of astemizole. ed in patients with significant liver disease.
    [Show full text]
  • Supporting Information a Analysed Substances
    Electronic Supplementary Material (ESI) for Analyst. This journal is © The Royal Society of Chemistry 2020 List of contents: Tab. A1 Detailed list and classification of analysed substances. Tab. A2 List of selected MS/MS parameters for the analytes. Tab. A1 Detailed list and classification of analysed substances. drug of therapeutic doping agent analytical standard substance abuse drug (WADA class)* supplier (+\-)-amphetamine ✓ ✓ S6 stimulants LGC (+\-)-methamphetamine ✓ S6 stimulants LGC (+\-)-3,4-methylenedioxymethamphetamine (MDMA) ✓ S6 stimulants LGC methylhexanamine (4-methylhexan-2-amine, DMAA) S6 stimulants Sigma cocaine ✓ ✓ S6 stimulants LGC methylphenidate ✓ ✓ S6 stimulants LGC nikethamide (N,N-diethylnicotinamide) ✓ S6 stimulants Aldrich strychnine S6 stimulants Sigma (-)-Δ9-tetrahydrocannabinol (THC) ✓ ✓ S8 cannabinoids LGC (-)-11-nor-9-carboxy-Δ9-tetrahydrocannabinol (THC-COOH) S8 cannabinoids LGC morphine ✓ ✓ S7 narcotics LGC heroin (diacetylmorphine) ✓ ✓ S7 narcotics LGC hydrocodone ✓ ✓ Cerillant® oxycodone ✓ ✓ S7 narcotics LGC (+\-)-methadone ✓ ✓ S7 narcotics Cerillant® buprenorphine ✓ ✓ S7 narcotics Cerillant® fentanyl ✓ ✓ S7 narcotics LGC ketamine ✓ ✓ LGC phencyclidine (PCP) ✓ S0 non-approved substances LGC lysergic acid diethylamide (LSD) ✓ S0 non-approved substances LGC psilocybin ✓ S0 non-approved substances Cerillant® alprazolam ✓ ✓ LGC clonazepam ✓ ✓ Cerillant® flunitrazepam ✓ ✓ LGC zolpidem ✓ ✓ LGC VETRANAL™ boldenone (Δ1-testosterone / 1-dehydrotestosterone) ✓ S1 anabolic agents (Sigma-Aldrich)
    [Show full text]
  • Medication Instructions for Allergy Patients
    MEDICATION INSTRUCTIONS FOR ALLERGY PATIENTS Drugs which contain antihistamine or have antihistaminic effects can result in negative reactions to skin testing. As a result, it may not be possible to properly interpret skin test results, and testing may have to be repeated at a later date. While this list is extensive, it is NOT all inclusive (particularly of the various brand names). Discontinue ALL antihistamines including the following medications seven (7) days prior to skin testing (unless longer time specified): Antihistamines – Generic name (Brand name(s)): Cetirizine (Zyrtec, Zyrtec-D) Hydroxyzine (Vistaril, Atarax) Desloratadine (Clarinex) Levocetirizine (Xyzal) Fexofenadine (Allegra, Allegra-D) Loratadine (Claritin, Claritin-D, Alavert) Diphenhydramine (Aleve PM, Benadryl, Bayer P.M., Benylin, Contac P.M., Doans P.M, Excedrin PM, Legatrin P.M.. Nytol, Tylenol Nighttime, Unisom, Zzzquil) Chlorpheniramine (Aller-Chlor, Allerest, Alka Seltzer Plus, Chlor-Trimeton, Comtrex, Contac, Co-Pyronil, Coricidin, CTM, Deconamine, Dristan, Dura-tap, Naldecon, Ornade Spansules, Rondec, Sinutab, Teldrin, Triaminic, Triaminicin, Tylenol Allergy) Azatadine (Optimine, Trinalin) Doxylamine (Nyquil) Brompheniramine (Bromfed, Dimetane, Dimetapp) Meclizine (Antivert) Carbinoxamine (Clistin, Rondec) Pheniramine Clemastine (Tavist) Phenyltoloxamine (Nadecon) Cyclizine (Marezine) Promethazine (Phenergan) Cyprohepatidine (Periactin) (9 days) Pyrilamine (Mepyramine) Dexbrompheniramine (Drixoral) Quinacrine (Atabrine) Dexchlorpheniramine (Extendryl, Polaramine)
    [Show full text]
  • Potential Drug-Drug Interactions and Adverse Drug Reactions Associated with Hydroxychloroquine
    Original Article Potential Drug-drug Interactions and Adverse Drug Reactions Associated with Hydroxychloroquine Arjun Singh1, Richa Chaudhary1, Prayas Verma2, Nilanchal Trivedi3,*, Md. Shamim4 1Department of Pharmacy Practice, Teerthanker Mahaveer College of Pharmacy, TMU, Moradabad, Uttar Pradesh, INDIA. 2Teerthanker Mahaveer Dental College and Research Centre, TMU Moradabad, Uttar Pradesh, INDIA. 3Department of Pharmacology, Teerthanker Mahaveer College of Pharmacy, TMU, Moradabad, Uttar Pradesh, INDIA. 4LCP College of Pharmacy Baghpat, Abdul Kalam Technical University (AKTU), Uttar Pradesh, INDIA. ABSTRACT Introduction: COVID-19 is a pandemic disaster and a health emergency of prime focus for all the world economies. Various prophylactic treatments are considered to combat the disease. Hydroxychloroquine drug is one such option that is given much attention as an armor against SARS COV-2 pandemic. Evaluation and assessment of drug interactions and ADRs is required from ethical concern to justify the use of HCQ on such large scale. Methods: We have performed an analysis of HCQ drug interactions on Micromedex®. We have reviewed literature of HCQ pharmacokinetic properties, ADRs/ ADEs and toxicities associated with the use of HCQ drug on PubMed, Google Scholar and CDC database. Results: There are around 180 drug interactions possible with HCQ. Out of them 13 are of contraindicated severity level and other 165 are of major severity and 2 of them are moderately severe. Most of the interactions are coupled with QT prolonging agents (170), Cardiac arrhythmias is possible with the concomitant use of at least 2 drugs, 4 drugs leads to Torsade de points. System organ level ADRs are also evaluated along with various precautions, warnings and contraindications.
    [Show full text]
  • (12) Patent Application Publication (10) Pub. No.: US 2007/0003580 A1 Loria Et Al
    US 20070003580A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2007/0003580 A1 Loria et al. (43) Pub. Date: Jan. 4, 2007 (54) ANTI-ALLERGIC PHARMACEUTICAL (30) Foreign Application Priority Data COMPOSITION CONTAINING AT LEAST ONE ALLERGEN AND AT LEAST ONE Mar. 30, 2001 (FR)............................................ O1/O437O ANTHSTAMINE COMPOUND May 3, 2001 (FR)............................................ O1/O5929 (76) Inventors: Emile Loria, La Jolla, CA (US); Publication Classification Gaetan Terrasse, Saint-Valier (FR); Yves Trehin, Toulouse (FR) (51) Int. Cl. A6IR 39/36 (2006.01) Correspondence Address: A6II 3L/495 (2006.01) MANDEL & ADRANO A61K 31/4172 (2006.01) SS SOUTH LAKEAVENUE A6II 3/473 (2006.01) SUTE 710 (52) U.S. Cl. ................ 424/275.1: 514/255.04: 514/400; PASADENA, CA 91101 (US) 514/290 (21) Appl. No.: 11/413,489 (57) ABSTRACT (22) Filed: Apr. 28, 2006 The present invention relates to an anti-allergic pharmaceu tical composition containing at least two active agents Related U.S. Application Data chosen from: (i) one allergen, (ii) one antihistamine com pound, and (iii) one inhibitor of histamine synthesis, said (63) Continuation-in-part of application No. 09/867,159, active agents being associated in said composition with a filed on May 29, 2001, now Pat. No. 7,048,928. pharmaceutically acceptable vehicle. US 2007/0003580 A1 Jan. 4, 2007 ANT-ALLERGIC PHARMACEUTICAL seen in atopic persons in whom allergic reactions are severe COMPOSITION CONTAINING AT LEAST ONE owing to the high level of Th2 clones promoting the Syn ALLERGEN AND AT LEAST ONE thesis of IgE. ANTHSTAMINE COMPOUND 0015 The general reaction observed subsequent to the 0001.
    [Show full text]
  • (19) United States (12) Patent Application Publication (10) Pub
    US 20130210835A1 (19) United States (12) Patent Application Publication (10) Pub. N0.2 US 2013/0210835 A1 Mitchell (43) Pub. Date: Aug. 15, 2013 (54) PHARMACEUTICAL COMPOSITIONS Publication Classi?cation (75) Inventor: Odes W. Mitchell; Arlington, TX (U S) (51) Int. Cl. A61K31/137 (2006.01) _ A611; 31/4402 (2006.01) (73) Ass1gnee: GM PHARMACEUTICAL, INC, A61K 31/485 (200601) Arhngton, TX (Us) A611; 31/09 (2006.01) _ A611; 31/495 (2006.01) (21) App1.No.. 13/703,584 A61K31/505 (200601) 22 PCT P1 d: J .13 2011 (52) us Cl ( ) 1e “n ’ CPC ........... .. A611; 31/137 (2013.01); A611;31/495 (86) PCT NO. PCT/“11,4031 (2013.01); A611;31/505 (2013.01); A611; 31/485 (2013.01); A611; 31/09 (2013.01); § 371 (0)0). A611;31/4402 (2013.01) (2), (4) Date: Feb- 2, 2013 USPC .... .. 514/255.04; 564/355; 514/653; 544/396; 544/332; 514/275; 546/74; 514/289; 514/282; Related US. Application Data 514657; 514652 (60) Provisional application No. 61/354,061; ?led on Jun. (57) ABSTRACT 11; 2010; provisional application No. 61/354,057; A composition of an antitussive; a decongestant; or an anti ?led on Jun. 11; 2010; provisional application No. histamine to treat respiratory and oral pharyngeal congestion 61/354,053; ?led on Jun. 11,2010. and related symptoms in a patient. US 2013/0210835 A1 Aug. 15,2013 PHARMACEUTICAL COMPOSITIONS mucus build-up to clear congestion in the air passages. Symp toms due to allergies or allergens are often treated With an CROSS-REFERENCES TO RELATED antihistamine.
    [Show full text]
  • Urticaria: Current Opinions About Etiology, Diagnosis and Therapy
    Acta Derm Venereol 2007; 87: 196–205 REVIEW ARTICLE Urticaria: Current Opinions about Etiology, Diagnosis and Therapy Torsten ZUBERBIER and Marcus MAURER Department of Dermatology and Allergy, Allergie-Centrum-Charité, Charité – Universitätsmedizin, Berlin, Germany In the last few decades an increasing understanding of British Association of Dermatologists (4) and the most the pathomechanisms involved in urticaria has highlight­ recent European Academy of Allergology and Clinical ed the heterogeneity of different subtypes. According to Immunology/Global Allergy and Asthma European Net- the new European Academy of Allergology and Clinical work/European Dermatology Forum (EAACI/GA²LEN/ Immunology/Global Allergy and Asthma European Net­ EDF) guidelines. For preparing the latter, more than work/European Dermatology Forum (EAACI/GA²LEN/ 300 specialists from over 15 countries held a consensus EDF) guidelines, urticaria subtypes can be grouped into meeting regarding the definition, classification, routine spontaneous urticaria, which includes acute urticaria diagnosis and management of urticaria. Evidence-ba- and chronic urticaria, the physical urticarias, and other sed suggestions, prepared by a panel in advance, were urticaria disorders, including, for example, contact ur­ discussed using a voting system (5, 6). ticaria. Clarity of nomenclature is required not only to Due to the heterogeneity of the disease, the interpre- choose the correct measures in diagnosis and manage­ tation of divergent data from different centres regarding ment, but also to compare data from different studies. eliciting causes in subtypes of urticaria and their therapeu- Urticaria has a profound impact on quality of life and tic responsiveness is, however, sometimes difficult, as the performance. Effective treatment is thus required in all influence of different study populations is considerable.
    [Show full text]
  • BETA RECEPTOR BLOCKERS MC Objective
    Jack DeRuiter, Principles of Drug Action 2, Fall 2000 ADRENERGIC RECEPTOR ANTAGONISTS: BETA RECEPTOR BLOCKERS MC Objective: Describe the development of beta antagonists ("beta blockers") from the agonist norepinephrine (NE): HO H NH2 NE Alpha- and Beta-receptor agonist HO OH H H HO CH N 3 H Isoproterenol CH3 Selective beta-receptor agonist HO OH H H HO CH N 3 H Dichloroisoproterenol CH3 Partial beta-receptor agonist/antagonist Cl Cl H H HO CH N 3 Pronethalol H Beta-receptor antagonist, CH 3 low activity and toxic CH3 O N H Propranolol CH3 OH H Potent beta-antagonist No beta-receptor subtype selectivity CH3 CH3 O N H O N H CH CH OH H 3 OH H 3 Metoprolol N Beta-1-receptor H Pindolol O subtype selectivity Partial beta-agonist CH3 No beta-receptor subtype selectivity HO H H N H CH3 HO Labetolol O NH2 Dual alpha- and beta-antagonst 1 Jack DeRuiter, Principles of Drug Action 2, Fall 2000 MC Objective: Based on their structures, would the beta-blockers be expected to be relatively receptor selective? YES. They do not produce significant blockade of alpha- adrenergic receptors (alpha-1 or alpha-2), histamine receptors, muscarinic receptors or dopamine receptors. MC/PC Objective: Identify which beta blockers are classified as "non-selective": · The “non-selective" classification refers to those beta-blockers capable of blocking BOTH beta-1 and beta-2 receptors with equivalent efficacy. These drugs DO NOT have clinically significant affinity for other neurotransmitter receptors (alpha, dopamine, histamine, acetylcholine, etc.). · ALL of these beta-blockers (except satolol) consist of an aryloxypropanolamine side chain linked to an aromatic or “heteroaromatic” ring which is “ortho” substituted.
    [Show full text]