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9 Th Leipzig Research Festival for Life Sciences J. Thiery, A. Beck-Sickinger, T. Arendt (Hrsg.) 9 th Leipzig Research Festival for Life Sciences 17. Dezember 2010 Veranstalter: Medizinische Fakultät der Universität Leipzig Fakultät für Biowissenschaften, Pharmazie und Psychologie der Universität Leipzig Interdisziplinäres Zentrum für Klinische Forschung (IZKF) der Universität Leipzig Translational Centre for Regenerative Medicine (TRM-Leipzig) Inhaltsverzeichnis Vorwort ......................................................... 5 Biophysics and Bioanalytics ................................ 6 Biotechnology ................................................. 28 ICCAS – Computer Assisted Surgery ..................... 39 Cell Biology .................................................... 54 Clinical Studies ................................................ 79 Drug Development and Delivery .......................... 104 Tumor Targeting .............................................. 118 IFB – Adiposity Diseases .................................... 129 Imaging ......................................................... 151 TRM – Tissue Repair and Replacement .................. 165 Immunology and Infectiology .............................. 179 LIFE – Civilisation Diseases and Genetics ............... 203 Molecular Biology/Protein Biochemistry ................. 222 Neurobiology .................................................. 267 Psychology and Cognition .................................. 313 Social Medicine ............................................... 327 Impressum: Evolution and Molecular Diversity ........................ 340 Index ............................................................. 350 Konzeption / Organisation: Prof. Dr. J. Thiery Prof. Dr. A. Beck-Sickinger, Prof. Dr. T. Arendt Lektorat: K. Duczek / I. Malerba Layout / Satz: K. Plath Titelbild: N. Sträter und A. Beck-Sickinger Auflage: 420 Exemplare ISBN: 978-3-9810760-6-6 9 th Leipzig Research Festival for Life Sciences 2010 Ort der Foyer Max-Bürger-Forschungszentrum Vorwort Veranstaltung: Johannisallee 30 · 04103 Leipzig Liebe Kolleginnen und Kollegen, liebe Gäste, Organisation: Prof. Dr. J. Thiery, K. Duczek wir begrüßen Sie sehr herzlich zu unserem neunten Leipziger Research Festival of Life Institut für Laboratoriumsmedizin, S c i e n c e s der Universität Leipzig. Die jährliche wissenschaftliche Leistungsschau gibt allen Klinische Chemie und Molekulare Diagnostik jungen »Life Science« Wissenschaftlern und Ärzten aus der Universitätsregion die Möglich- Universitätsklinikum Leipzig AöR keit, ihre neuesten Forschungsergebnisse in einer öffentlichen »Wissenschaftswerkstatt« zu Liebigstraße 27 · 04103 Leipzig präsentieren. Die hohe Zahl von Abstracteinsendungen unterstreicht die Attraktivität dieses Telefon: (03 41) 97 224 93 weit über die Fächergrenzen reichenden wissenschaftlichen Kommunikationsforums. Der Fax: (03 41) 97 222 09 vorliegende Abstract-Band soll auch der interessierten Öffentlichkeit, der Politik und In- E-Mail: [email protected] dustrieunternehmen dienen, die facettenreiche Aktivität und die Erfolge der Leipziger Wis- senschaftslandschaft gerade im Bereich »Life Science« und der gesamten Medizin kennen Prof. Dr. A. Beck-Sickinger zu lernen. Der Band ist mit Stichpunkten zur Forschungskompetenz und email-Verweisen Institut für Biochemie zugleich ein wissenschaftliches »who is who«, um schnelle Problemlösungen durch Zusam- Fakultät für Biowissenschaften, Pharmazie und Psychologie menarbeit »next door« zu erleichtern. Universität Leipzig Mit besonderer Wertschätzung des wissenschaftlichen Nachwuchses werden auch in die- Talstraße 33 · 04103 Leipzig sem Jahr die besten Posterpräsentationen mit den renommierten Forschungspreisen des Telefon: (03 41) 97 369 00 Research Festivals Leipzig ausgezeichnet. Fax: (03 41) 97 369 98 Wir werden in diesem Jahr auch den kompetitiv eingeworbenen Forschungsverbünden E-Mail: [email protected] in den Lebenswissenschaften an der Universität Leipzig einen besonderen Raum ge- ben, um Vorhaben und Ergebnisse im Rahmen der Landesexzellenzinitiative und Leipzi- Prof. Dr. T. Arendt ger Forschungszentrums für Zivilisationserkrankungen: LIFE, des Integrierten Forschungs- Paul-Flechsig-Institut für Hirnfoschung und Behandlungszentrums: IFB Adipositas Erkrankungen, des Translationszentrums für Jahnallee 59 · 04109 Leipzig Regenerative Medizin: TR M und des Kompetenzzentrums für computerassistierte Chirurgie: Telefon: (03 41) 97 257 20 ICCAS zu präsentieren und zur Diskussion zu stellen. Fax: (03 41) 97 257 29 Wir hoffen, dass unser Research Festival auch in diesem Jahr seinen doppelten Zweck, die E-Mail: [email protected] Präsentation eigener innovativer Forschungsergebnisse und Kontaktforum mit jungen und älteren Wissenschaftlern und Ärzten über Fach- und Hierarchiegrenzen hinaus, erfüllen Für die Unterstützung der Veranstaltung danken wir: wird. Das Research Festival begleitet und stärkt somit die zukunftsweisende Entwicklung des biomedizinischen und biotechnologischen Standorts der Universität Leipzig. Fakultät für Biowissenschaften, Pharmazie und Psychologie Für die engagierte Mitarbeit, ohne die dieses Festival nicht zustande gekommen wäre, Talstraße 33 · 04103 Leipzig danken wir allen Unterstützern sehr. Profilbildender Forschungsbereich III Prof. Dr. Annette Beck-Sickinger Prof. Dr. Matthias Müller Medizinische Fakultät der Universität Leipzig Institut für Biochemie, Fakultät für Biowissen- Dekan der Fakultät für Biowissenschaften, schaften, Pharmazie und Psychologie, Pharmazie und Psychologie Bundesministerium für Bildung und Forschung (BMBF) Sprecherin des Profilbildenden Forschungs- bereichs 3, Universität Leipzig Prof. Dr. Markus Löffler Sprecher von LIFE Translational Centre for Regenerative Medicine (TRM) Prof. Dr. Joachim Thiery Philipp-Rosenthal-Straße 55 · 04103 Leipzig Institut für Laboratoriumsmedizin, Klinische Prof. Dr. Frank Emmrich Chemie und Molekulare Diagnostik, Translationszentrum für Regenerative Medizin IFB Adiposity Diseases Leipzig Universitätsklinikum Leipzig, Dekan der Prof. Dr. Michael Stumvoll Medizinischen Fakultät, Sprecher von LIFE IFB AdipositasErkrankungen LIFE – Leipziger Forschungszentrum für Zivilisationserkrankungen Prof. Dr. Thomas Arendt Prof. Dr. Jürgen Meixensberger Interdisziplinäres Zentrum für Klinische ICCAS – Innovation Center Computer Assisted Surgery Forschung, Universität Leipzig ICCAS 5 9 th Leipzig Research Festival for Life Sciences 2010 9 th Leipzig Research Festival for Life Sciences 2010 POSTER 1 Erhebung von Blutrichtwerten beim Weißbüschelaffen POSTER 2 Structure and function of a novel dienelactone hydrolase (Callithrix jacchus) Roth C1, Schlömann M2, Sträter N1 Kühnel F1,2, Grohmann J1, Buchwald U1,2, Köller G3, 1 Faculty for Chemistry and Mineralogy, Structural Analytics of Teupser D2, Einspanier A1,2 Biopolymers, University Leipzig , Germany 1 Veterinär-Physiologisch-Chemisches Institut, Universität Leipzig 2 Faculty for Chemistry and Physics, Environmental Microbiology, TU 2 LIFE – Leipziger Forschungszentrum für Zivilisationserkrankungen, Bergakademie Freiberg, Germany Universität Leipzig 3 Medizinische Tierklinik, Universität Leipzig List of topics Fluoroaromatic compounds are widely used as pesticides or phar- maceuticals and well known environmental pollutants. The bacte- List of topics Weißbüschelaffen sind unter anderem ein geeignetes Tiermodell Biophysics and Bioanalytics rium Cupriavidus necator is able to degrade such compounds via a für toxikologische, kognitive und Fertilitätsstudien. Es existiert je- Biotechnology modified variant of the ß-ketoadipate pathway. One of the key en- Biophysics and Bioanalytics doch wenig Information über die klinisch-chemischen Parameter, ICCAS – Computer Assisted Surgery zymes is the trans-dienelactone hydrolase (t-DLH) which degrades Biotechnology um ihren Gesundheitsstatus einzuschätzen. Deshalb war das Ziel Cell Biology (fluoro)dienelactone leading to maleylacetate. The t-DLH from C. ICCAS – Computer Assisted Surgery der vorliegenden Studie, Richtwerte für Blutbild, klinische Chemie Clinical Studies necator is a monomeric enzyme with a molecular weight of ap- Cell Biology und Lipidparameter zu erstellen. Dazu wurden 54 adulte Weißbü- Drug Development and Delivery proximately 38 kDa. The enzyme shows no significant similarity Clinical Studies schelaffen (28 weibliche, 26 männliche) mit standardisierter Hal- Tumor Targeting to other known dienelactone hydrolases. Furthermore C. necator Drug Development and Delivery tung und Fütterung untersucht. Die Blutabnahme erfolgte an nüch- IFB – Adiposity Diseases t-DLH shows activity only in the presence of divalent cations like Tumor Targeting ternen Tieren mit anschließender Analyse. Dabei zeigte sich, dass Imaging Mn2+ or Mg2+. IFB – Adiposity Diseases alle Parameter der klinischen Chemie für männliche und weibli- TRM – Tissue Repair and Replacement The gene of t-DLH was cloned expressed in E.coli. The protein was Imaging che Tiere ähnlich sind, bis auf das Gesamt- und LDL- Choleste- Immunology and Infectiology purified to at least 90 % homogenity. The wildtype was subjected TRM – Tissue Repair and Replacement rol, mittleres Erythrozytenvolumen (MCV) und mittleres Hämo- LIFE – Civilisation Diseases and Genetics to crystallization trials using sparse matrix screens. Suitable crystal- Immunology and Infectiology globin pro Erythrozyt (MCH). Männliche Weißbüschelaffen haben Molecular Biology/Protein Biochemistry lization conditions could not be identified for this variant. Mutants LIFE – Civilisation
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