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Abstract Book ORAL PRESENTATIONS Glaucoma XXII Biennial Meeting of the International Society for Eye Research September 25-29, 2016 | Tokyo, Japan ABSTRACT BOOK www.iserbiennialmeeting.org1 CONTENT Glaucoma 6 GLA1 - Cell Plasticity, Fibrogenic Mechanisms and Glaucoma 6 GLA2 - Major identifi ed players in glaucoma – genes and signaling pathways 8 GLA3 - Restoring Conventional Outfl ow 11 GLA4 - ONH/NFL imaging in glaucoma 13 GLA6 - Biomechanics of glaucoma 18 GLA7 - Biology of the TM 21 GLA8 - Distal Outfl ow Resistance: Towards Understanding MIGS 23 GLA9 - Status of glaucoma gene and stem cell therapy 25 GLA10 - Lymphangiogenesis, Lymphatics and IOP Regulation 29 JNT1 (GLA+OMG) - Genetics of glaucoma 30 Lens 33 LEN1 - Lens Development 33 LEN2 - Oxidative Stress 35 LEN3 - Biomarkers in Cataractogenesis 37 LEN4 - Lens Regeneration and Evolution 40 LEN6 - Animal Models of Cataract 45 LEN7 - Lens Cytoskeleton 47 LEN8 - Post-translational modifi cation of crystallins 50 LEN9 - PCO/EMT 52 LEN10 - The Zonule of Zinn: biology and pathology 55 LEN11 - Alpha crystallins and small heat-shock proteins 57 LEN12 - Physiological Optics 58 Cornea and Ocular Surface 62 COS1 - Corneal Infection 62 COS2 - Emerging paradigms in stromal regenerative biology 63 COS3 - Corneal Endothelium: Pathophysiology and Treatment 65 COS4 - Corneal Refractive Surgeries 68 COS5 - Cornea Transplantation and keratoprothesis 69 COS6 - Keratoconus biology and treatment 71 COS7 - New Diagnosis and Therapies for Corneal Diseases 73 COS8 - Ocular Surface Epithelial Homeostasis (Conjunctival, Limbal, Corneal) 75 COS9 - Reimbursement of Ocular Surface Cell Based therapies -Bottlenecks in Bioprocessin 77 COS10 - Dry Eye 79 Ocular Immunology 81 IMM4 - Innate mechanisms that contribute to RPE pathology 81 JNT2 (IMM+RPE) - RPE and Infl ammation 83 JNT3 (IMM+RCB) - Microglia and macrophages as therapy targets for retinal diseases 85 JNT6 (IMM+OPT) - Molecular mechanisms of fi brosis in eye tissues 87 JNT10 (IMM+OPT) - New molecular mechanisms and therapeutic approaches for uveitis 89 JNT12 (IMM+RPE) - RPE regulation of innate immune activity and functionality in macrophages 91 2 CONTENT Ocular Imaging 95 IMA1 - New advances in ocular imaging - part II 95 IMA2 - New advances in ocular imaging - part I 96 IMA3 - OCT angiography and Doppler OCT 99 IMA4 - Functional & contrast enhanced imaging 101 IMA5 - Imaging in glaucoma and myopia 103 IMA6 - AO in vision sciences 104 RPE Choroid Biology and Pathology 106 RPE2 - Lipid dynamics at the photoreceptor-RPE nexus 106 RPE4 - VEGF and beyond 108 RPE6 - The Next Best thing: Making sense of the bestrophinopathies 110 RPE7 - Metabolic Coupling in the outer retina 112 RPE8 - Exploring the intersection between infl ammation and lipid metabolism in age-related macular degeneration (AMD) 115 RPE9 - Infl ammasomes in the RPE 117 RPE11 - Aging RPE: Proteostasis mechanisms in health and diseases 119 RPE12 - RPE dysfunction in AMD: From oxidative damage to infl ammasome activation 121 RPE13 - Lymphatics and fl uid movement in the posterior eye: Recent advances and remaining controversies 125 Retinal Cell Biology 128 RCB1 - New insights on the RPE/Bruchs membrane/choriocapillaris in AMD 128 RCB2 - Infl ammation in AMD 130 RCB3 - Retinopathy of Prematurity 132 RCB5 - Assembly and Maintenance of the Phototransduction Organelle 137 RCB6 - Oxidative and ER Stress in Retinal Degenerations 139 RCB7 - Mouse to Human: Modeling AMD 142 RCB8 - Retinoids in vision 143 JNT4 (RCB+RPE) - Understanding Diabetic Retinopathy and AMD through animal models 145 Retinal Neuroscience and Development 148 RND1 - Transcription control of retinal cell identity 148 RND2 - Epigenetics in development and disease 149 RND3 - Cell-cell signaling and retinal development 153 RND4 - Establishment of retinal circuitry and synapses 154 RND5 - Retinal circuitry and visual signal processing 157 RND6 - RGC axonal targeting and regeneration 158 RND7 - Retinal regeneration through controlled dedifferentiation 160 RND8 - Mechanisms of neuroprotection 162 RND9 - Modeling human retinal disease 164 RND10 - Noncoding RNA in retinal development and disease 167 RND11 - Ca++ signaling in retinal ganglion cells and outer retinal neurons 169 JNT5 (RND+RCB) - ES/iPS-based approaches to treating retinal dystrophies 171 3 CONTENT Ocular Pharmacology and Therapeutics 174 OPT1 - Translational studies in glaucoma - How do we make basic science studies in glaucoma more clinically relevant: Development of a consensus 174 OPT2 - Translational ophthalmology: Novel targets and their development into the clinic 176 OPT6 - Matching clinical needs and novel drug delivery systems for the posterior segment of the eye 178 OPT7 - Novel molecular mechanisms of diabetic retinopathy 180 OPT8 - Prostaglandins for Ocular Hypertension Treatment: A new Era is Dawning 182 OPT9 - Blue light and circadian system 185 OPT10 - TBI (traumatic brain injury): Visual dysfunction and treatment 186 OPT11 - Dry eye diagnosis 188 OPT12 - Imaging biomarkers for retinal diseases 190 OPT13 - Gene delivery to the eye 192 OPT15 - Innovative approaches for retinal degeneration and therapy 194 JNT8 (OPT+GLA) - Sustained glaucoma therapy and ocular drug delivery 197 JNT9 (OPT+GLA) - Therapeutic targets for retinal dissease: Lessons learnt form bench side 199 JNT11 (OPT+IMM) - An intersection of receptor signaling pathways with neuroinfl ammation (infl ammasome) 201 Ophthalmic Genomics 204 OGM1 - Genetics of multifactorial eye diseases 204 OGM2 - Molecular Genetics of Eye Disease 205 OGM3 - Asian eye genetics 207 OGM4 - Epigenetic Modifi cations And Non-Coding RNAs In The Ocular Health and Disease 210 OGM5 - Congenital stationary night blindness from A-Z 211 OGM6 - An omics perspective on pediatric eye diseases 213 OGM7 - Genetics of corneal dystrophies 215 OGM9 - Genomics of ophthalmic diseases 217 OGM10 - Genetics of Retinal Degenerations 219 OGM11 - Genetics of myopia 221 OGM12 - Current concept in genetics of hereditary ocular developmental anomalies 223 JNT7 (OGM+GLA) - Genetics of normal tension glaucoma 225 Independent Session 228 IND1 - Expanding the functions of ocular surface innevation: photophobia and photoallodynia 228 IND2 - Electrophysiology of Vision 230 IND3 - Oxidative Stress in Ocular Tissue 232 IND4 - Cell-signaling in anterior segment development and dieases 234 IND5 - Meibomian Glands and Meibum - From Biochemistry to Physiology to Disease 236 IND6 - Autophagy in eye health and disorders 238 IND7 - Plasticity in the Visual System 240 4 CONTENT Posters | Monday, September 26 243 Glaucoma 244 Lens 248 Cornea and Ocular Surface 252 Ocular Immunology 256 Ocular Imaging 257 RPE Choroid Biology and Pathology 261 Retinal Cell Biology 263 Retinal Neuroscience and Development 272 Ocular Pharmacology and Therapeutics 276 Ophthalmic Genomics 284 Posters | Tuesday, September 27 286 Glaucoma 286 Lens 291 Cornea and Ocular Surface 294 Ocular Immunology 300 Ocular Imaging 301 RPE Choroid Biology and Pathology 304 Retinal Cell Biology 307 Retinal Neuroscience and Development 317 Ocular Pharmacology and Therapeutics 322 Ophthalmic Genomics 329 Author Index 331 5 ORAL PRESENTATIONS Glaucoma GLA1 - Cell Plasticity, Fibrogenic Mechanisms and Scleral and Lamina Cribrosa Remodeling in Glaucoma Response to Chronically Elevated IOP The Role of AP-2β in Anterior Segment Dysgenesis/ J. CRAWFORD DOWNS Fibrosis and Glaucoma University of Alabama at Birmingham, Ophthalmology, Birmingham, United States JUDITH WEST-MAYS1 , Vanessa Mar tino1, Alexander Ball1, Trevor Williams2 Glaucoma is a leading cause of blindness in the developed 1McMaster University, Pathology and Molecular Medicine, world, yet little is known about the mechanisms underlying Hamilton, Canada, 2University of Colorado, Craniofacial its development or progression. Progressive remodeling Biology, Denver, United States of the load-bearing connective tissues (lamina cribrosa (LC) and sclera) of the optic nerve head (ONH) is a Anterior segment dysgenesis (ASD) encompasses a defining feature of glaucoma. This remodeling alters the group of developmental disorders in which a closed microenvironment of the retinal ganglion cell (RGC) angle phenotype in the anterior chamber of the eye can axons traversing the ONH and manifests at the macro-, occur and 50% of patients develop glaucoma. Many ASDs micro-, and cellular scales. While intraocular pressure are thought to involve an inappropriate patterning and (IOP) is currently the only known modifiable risk factor for migration of the periocular mesenchyme (POM), which glaucoma, the disease can occur at statistically ‘normal’ is derived from cranial neural crest cells (NCC) and IOPs and can progress despite IOP lowering. mesoderm. Although, the mechanism of this disruption is Cell-driven progressive remodeling of the load-bearing not well understood a number of transcriptional regulatory ONH connective tissues (cupping and excavation of the molecules have previously been implicated in ASDs. Here LC and sclera) is the defining feature of glaucoma as it we use a loss of function approach in mice to investigate compares to other optic neuropathies. It is unknown how the function of transcription factor AP-2β, encoded by eye-specific differences in ONH structural stiffness and/ Tfap2b, which is expressed in the neural crest and its or cellular reactivity increase glaucoma susceptibility derivatives. Since full germ-line AP-2β knockout mice are or contribute to disease progression. IOP-related stress not viable past birth, we employed a knockout approach (force/cross sectional
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