Guidelines for Disinfecting and Sanitizing with Bleach Solution
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Chemical Disinfectants for Biohazardous Materials (3/21)
Safe Operating Procedure (Revised 3/21) CHEMICAL DISINFECTANTS FOR BIOHAZARDOUS MATERIALS ____________________________________________________________________________ Chemicals used for biohazardous decontamination are called sterilizers, disinfectants, sanitizers, antiseptics and germicides. These terms are sometimes equivalent, but not always, but for the purposes of this document all the chemicals described herein are disinfectants. The efficacy of every disinfectant is based on several factors: 1) organic load (the amount of dirt and other contaminants on the surface), 2) microbial load, 3) type of organism, 4) condition of surfaces to be disinfected (i.e., porous or nonporous), and 5) disinfectant concentration, pH, temperature, contact time and environmental humidity. These factors determine if the disinfectant is considered a high, intermediate or low-level disinfectant, in that order. Prior to selecting a specific disinfectant, consider the relative resistance of microorganisms. The following table provides information regarding chemical disinfectant resistance of various biological agents. Microbial Resistance to Chemical Disinfectants: Type of Microbe Examples Resistant Bovine spongiform encephalopathy (Mad Prions Cow) Creutzfeldt-Jakob disease Bacillus subtilis; Clostridium sporogenes, Bacterial Spores Clostridioides difficile Mycobacterium bovis, M. terrae, and other Mycobacteria Nontuberculous mycobacterium Poliovirus; Coxsackievirus; Rhinovirus; Non-enveloped or Small Viruses Adenovirus Trichophyton spp.; Cryptococcus sp.; -
EH&S COVID-19 Chemical Disinfectant Safety Information
COVID-19 CHEMICAL DISINFECTANT SAFETY INFORMATION Updated June 24, 2020 The COVID-19 pandemic has caused an increase in the number of disinfection products used throughout UW departments. This document provides general information about EPA-registered disinfectants, such as potential health hazards and personal protective equipment recommendations, for the commonly used disinfectants at the UW. Chemical Disinfectant Base / Category Products Potential Hazards Controls ● Ethyl alcohol Highly flammable and could form explosive Disposable nitrile gloves Alcohols ● ● vapor/air mixtures. ● Use in well-ventilated areas away from o Clorox 4 in One Disinfecting Spray Ready-to-Use ● May react violently with strong oxidants. ignition sources ● Alcohols may de-fat the skin and cause ● Wear long sleeve shirt and pants ● Isopropyl alcohol dermatitis. ● Closed toe shoes o Isopropyl Alcohol Antiseptic ● Inhalation of concentrated alcohol vapor 75% Topical Solution, MM may cause irritation of the respiratory tract (Ready to Use) and effects on the central nervous system. o Opti-Cide Surface Wipes o Powell PII Disinfectant Wipes o Super Sani Cloth Germicidal Wipe 201 Hall Health Center, Box 354400, Seattle, WA 98195-4400 206.543.7262 ᅵ fax 206.543.3351ᅵ www.ehs.washington.edu ● Formaldehyde Formaldehyde in gas form is extremely Disposable nitrile gloves for Aldehydes ● ● flammable. It forms explosive mixtures with concentrations 10% or less ● Paraformaldehyde air. ● Medium or heavyweight nitrile, neoprene, ● Glutaraldehyde ● It should only be used in well-ventilated natural rubber, or PVC gloves for ● Ortho-phthalaldehyde (OPA) areas. concentrated solutions ● The chemicals are irritating, toxic to humans ● Protective clothing to minimize skin upon contact or inhalation of high contact concentrations. -
US EPA, Pesticide Product Label, CLOROX BLEACH, 09/13/2011
UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, DC 20460 OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION September 13, 2011 Ms. J. Evelyn Lawson Senior Regulatory Information Scientist The Clorox Company C/o PS&RC; P. O. Box 493 Pleasanton, CA 94566-0803 Subject: Notification Application per PR Notice 98-10 Clorox Bleach EPA Registration Number 5813-1 Application Date: August 22, 2011 EPA Receipt Date: August 23, 2011 Dear Ms. Lawson: This acknowledges receipt of the above notification application, submitted under the provision of PR Notice 98-10, FIFRA 3(c)9. Proposed Notifications: • Add an ingredient disclosure website on page 32; • Updated EPA Est. information including alternate language for Puerto Rico, and updated year. General Comments: Based on a review of the material submitted, the following comment applies: The notification application is acceptable. A copy of the accepted notification has been inserted in your file for future reference. Should you have any questions or comments concerning this letter, please contact Adam Heyward via email at heyward. adam(q),epa.gov or by telephone at (703) 347-0274 during the hours of 6:00 am to 2:30 pm EST. MbWsBS Harris^ Product Manager (32) Regulatory Management Branch II Antimicrobials Division (751 OP) a/Sf Plftte reid instruction* on nv»r*e b»for» coir I'm form. Form Aporov OMB No. 2070-O06O. Approval expire* 2-28-95 United States Registration OPP Identifier Number Environmental Protection Agency &EPA Amendment EL0359 Washington, OC 20460 Other Application for Pesticide - Section I 1. Company/Product Number 2. EPA Product Manager 3. Proposed Classification 5813-1 Monisha Harris None Restricted 4. -
For Peer Review Only - Page 1 of 27 BMJ Open
BMJ Open BMJ Open: first published as 10.1136/bmjopen-2015-010387 on 4 April 2016. Downloaded from FALSIFIED MEDICINES IN PERU: A Retrospective Review (1997-2014). ForJournal: peerBMJ Open review only Manuscript ID bmjopen-2015-010387 Article Type: Research Date Submitted by the Author: 27-Oct-2015 Complete List of Authors: Medina, Edwin; University of Barcelona - Faculty of Pharmacy, Department of Pharmacy and Pharmaceutical Technology Bel, Elvira; University of Barcelona - Faculty of Pharmacy, Department of Pharmacy and Pharmaceutical Technology Suñé, Josep María; University of Barcelona - Faculty of Pharmacy, Department of Pharmacy and Pharmaceutical Technology <b>Primary Subject Public health Heading</b>: Secondary Subject Heading: Global health, Epidemiology, Health policy, Health services research Keywords: Safety, Falsified, Medicines, Alerts, counterfeit, Drugs http://bmjopen.bmj.com/ on September 24, 2021 by guest. Protected copyright. For peer review only - http://bmjopen.bmj.com/site/about/guidelines.xhtml Page 1 of 27 BMJ Open BMJ Open: first published as 10.1136/bmjopen-2015-010387 on 4 April 2016. Downloaded from 1 2 3 FALSIFIED MEDICINES IN PERU: A Retrospective Review (1997-2014). 4 5 6 7 Authors: Edwin Medina1, Elvira Bel1, Josep María Suñé1 8 9 10 11 12 Affiliations: 13 14 15 1. DepartmentFor of peerPharmacy and review Pharmaceutical onlyTechnology, Faculty of 16 Pharmacy, University of Barcelona, Spain 17 18 19 20 Corresponding author: 21 22 Edwin Salvador Medina Vargas 23 24 Department of Pharmacy and Pharmaceutical Technology 25 Faculty of Pharmacy 26 University of Barcelona 27 Joan XXIII, s/n, 08028 Barcelona 28 29 Spain 30 Email: [email protected] 31 32 33 http://bmjopen.bmj.com/ 34 Keywords: Safety, Falsified, Medicines, Alerts, counterfeit, Drugs 35 36 37 38 39 Word Count 40 41 Abstract: 298 on September 24, 2021 by guest. -
Decontamination of Rooms, Medical Equipment and Ambulances Using an Aerosol of Hydrogen Peroxide Disinfectant B.M
Journal of Hospital Infection (2006) 62, 149–155 www.elsevierhealth.com/journals/jhin Decontamination of rooms, medical equipment and ambulances using an aerosol of hydrogen peroxide disinfectant B.M. Andersena,*, M. Rascha, K. Hochlina, F.-H. Jensenb, P. Wismarc, J.-E. Fredriksend aDepartment of Hospital Infection, Ulleva˚l University Hospital, Oslo, Norway bDivision of Pre-hospital Care, Ulleva˚l University Hospital, Oslo, Norway cDepartment of Medical Equipment, Ulleva˚l University Hospital, Oslo, Norway dHealth and Environment AS, Oslo, Norway Received 17 November 2004; accepted 1 July 2005 KEYWORDS Summary A programmable device (Sterinis, Gloster Sante Europe) Room decontamina- providing a dry fume of 5% hydrogen peroxide (H2O2) disinfectant was tion; Ambulance tested for decontamination of rooms, ambulances and different types of decontamination; medical equipment. Pre-set concentrations were used according to the Medical equipment decontamination; volumes of the rooms and garages. Three cycles were performed with Hydrogen peroxide increasing contact times. Repetitive experiments were performed using fume decontamina- Bacillus atrophaeus (formerly Bacillus subtilis) Raven 1162282 spores to tion; Spore test control the effect of decontamination; after a sampling plan, spore strips were placed in various positions in rooms, ambulances, and inside and outside the items of medical equipment. Decontamination was effective in 87% of 146 spore tests in closed test rooms and in 100% of 48 tests in a surgical department when using three cycles. One or two cycles had no effect. The sporicidal effect on internal parts of the medical equipment was only 62.3% (220 tests). When the devices were run and ventilated during decontamination, 100% (57/57) of spore strips placed inside were decontaminated. -
Evaluating Disinfectants for Use Against the COVID-19 Virus
When it comes to choosing a disinfectant to combat the COVID-19 virus, research and health authorities suggest not all disinfectants are equally effective. The difference is in their active ingredient(s). HEALTH CANADA AND U.S. EPA ASSESSMENTS The work to evaluate disinfectants perhaps best starts with lists of approved disinfectants compiled by government health authorities. Health Canada has compiled a list of 85 hard surface disinfectant products (as of March 20, 2020) that meet their requirements for disinfection of emerging pathogens, including the virus that causes COVID-19. It can be accessed here. You can wade through the entire list. But if you locate the Drug Identification Number (DIN) on the disinfectant product label or the safety data sheet (SDS), then you can use the search function to quickly see if the product meets Health Canada requirements. A second list, updated on March 19, 2020, provides 287 products that meet the U.S. Environmental Protection Agency’s (EPA) criteria for use against SARS-CoV-2, the novel coronavirus that causes the disease COVID-19. This list can be found here. Like the Health Canada list, you can wade through this one too. However, to best use this list, you should locate the U.S. EPA registration number on the product label or SDS, and use that number to search the list. The U.S. EPA registration number of a product consists of two sets of numbers separated by a hyphen. The first set of numbers refers to the company identification number, and the second set of numbers following the hyphen represents the product number. -
Hydroxy- -Methylbutyrate (Hmb)
(19) *EP003373740B1* (11) EP 3 373 740 B1 (12) EUROPEAN PATENT SPECIFICATION (45) Date of publication and mention (51) Int Cl.: of the grant of the patent: A23K 10/10 (2016.01) A23L 33/10 (2016.01) 24.02.2021 Bulletin 2021/08 (86) International application number: (21) Application number: 16864978.8 PCT/US2016/061278 (22) Date of filing: 10.11.2016 (87) International publication number: WO 2017/083487 (18.05.2017 Gazette 2017/20) (54) COMPOSITIONS AND METHODS OF USE OF -HYDROXY- -METHYLBUTYRATE (HMB) AS AN ANIMAL FEED ADDITIVE ZUSAMMENSETZUNGEN UND VERFAHREN ZUR VERWENDUNG VON BETA-HYDROXY-BETA-METHYLBUTYRAT (HMB) ALS FUTTERZUSATZ COMPOSITIONS ET PROCÉDÉS D’UTILISATION DE -HYDROXY- -MÉTHYLBUTYRATE (HMB) COMME ADDITIF D’ALIMENT POUR ANIMAUX (84) Designated Contracting States: • BAIER, Shawn AL AT BE BG CH CY CZ DE DK EE ES FI FR GB Polk City, Iowa 50226 (US) GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (74) Representative: Evans, Jacqueline Gail Victoria Marches Intellectual Property Limited (30) Priority: 10.11.2015 US 201562253428 P Wyastone Business Park Wyastone Leys (43) Date of publication of application: Ganarew 19.09.2018 Bulletin 2018/38 Monmouth NP25 3SR (GB) (73) Proprietor: Metabolic Technologies, Inc. (56) References cited: Ames, IA 50010 (US) WO-A1-2004/037010 US-A- 5 028 440 US-A- 5 087 472 US-A- 5 087 472 (72) Inventors: US-A- 6 103 764 US-A1- 2014 249 223 • FULLER, John US-A1- 2015 025 145 Zearing, Iowa 50278 (US) • RATHMACHER, John Story City, Iowa 50248 (US) Note: Within nine months of the publication of the mention of the grant of the European patent in the European Patent Bulletin, any person may give notice to the European Patent Office of opposition to that patent, in accordance with the Implementing Regulations. -
Safer Disinfectant Use in Child Care and Schools During the COVID-19 Pandemic
Safer Disinfectant Use in Child Care and Schools During the COVID-19 Pandemic Vickie Leonard, PhD Environmental Health in Early Care and Educaon Project, Western States Pediatric Environmental Health Specialty Unit (WSPEHSU) 1 Why Should We Be Concerned about Environmental Health in ECE? 2 Why Should We Be Concerned about Environmental Health in ECE? • There are 8 million children in child care centers in the U.S. A child may spend up to 12,500 hours in an ECE facility. A million child care providers work in these centers in the U.S. Half are child-bearing age. • Many toxicants found in child care facilities are not addressed in state child care health and safety regulations. • No agency at the state or federal level is charged with ensuring children’s health and safety in and around schools and ECE facilities. • No systematic means exists for collecting data on environmental exposures in these buildings. • Teachers have more protection in these buildings (unions, OSHA) than children do 3 Why Should We Be Concerned about Environmental Health in ECE? • Many people think that adults and children are exposed to, and affected by, toxic chemicals in the same way. • This is not the case. • Children • have higher exposures to toxicants in the environment, • are more vulnerable to the effects of those toxicants than adults. 4 Cleaning and Disinfec?ng Products: A Major Source of Exposure in Child Care and Schools • Products used to clean, sanitize and disinfect child care facilities and schools are a good example of the pervasive and unregulated use of toxic chemicals that put the health of our children at risk. -
Bleach, the Final Frontier
BLEACH, THE FINAL FRONTIER By dj Date Masamune Also, friendly reminder from Kenpachi-sama… Need to Knows • Panel will be available online + my resources on my blog • Will upload .pdf of PowerPoint that will be available post-con • Contact info. • Take a business card before you leave • If you have any questions left, feel free to ask me after the panel or e-mail me • ‘Discussion panel’ is nothing w/o the discussion part ~^.^~ How It’s Going to Be… • For every arc, I’ll do a super quick, super basic summation (accompanied by a crapload of pics), then everyone else can add in their own things, move the crap on rapidly, rinse & repeat • i.e., everyone gets a chance to talk • So, none of that “anime expert”/“I know more than the panelist” b.s. • Important mindset to have: Bleach is a recently ended train wreck you can never look away from Tite Kubo Audience SO LET’S GET STARTED~! & may kami-sama help us all ~.~; AGENT OF THE SHINIGAMI, SNEAK ENTRY, & THE RESCUE ARC Episodes 1-63 Manga: 1-182 Ishida Uryuu Chad Yasutora Ichigo Kurosaki Orihime Inoue Chizuru Honsho Mizuiro Kojima Asano Keigo Tatsuki Arisawa Mizuho Asano Yuzu & Karin Don Kanonji Kon Genryusai Yamamoto Soi Fon Gin Ichimaru Retsu Unohana Sousuke Aizen Zanpakuto: (Sui-Feng) Zanpakuto: Zanpakuto: Zanpakuto: Ryujin Jakka Zanpakuto: Shinsou Minazuki Kyoka Suigetsu Suzemabachi Zanpakuto: Bankai: Bankai: Bankai: Zanka no Tachi Kamishini no Yari *Suzumushi Jakuho Raikoben Bankai: Zanpakuto: Zanpakuto: Suzumushi Senbonzakura Tenken Tsuishiki: Enma Bankai: Bankai: Zanpakuto: Korogi Senbonzakura -
Amoxicillin in Water: Insights Into Relative Reactivity, Byproduct Formation, and Toxicological Interactions During Chlorination
applied sciences Article Amoxicillin in Water: Insights into Relative Reactivity, Byproduct Formation, and Toxicological Interactions during Chlorination Antonietta Siciliano 1 , Marco Guida 1 , Giovanni Libralato 1 , Lorenzo Saviano 1, Giovanni Luongo 2 , Lucio Previtera 3, Giovanni Di Fabio 2 and Armando Zarrelli 2,* 1 Department of Biology, University of Naples Federico II, 80126 Naples, Italy; [email protected] (A.S.); [email protected] (M.G.); [email protected] (G.L.); [email protected] (L.S.) 2 Department of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy; [email protected] (G.L.); [email protected] (G.D.F.) 3 Associazione Italiana per la Promozione delle Ricerche su Ambiente e Salute umana, 82030 Dugenta, Italy; [email protected] * Correspondence: [email protected]; Tel.: +39-08-167-4472 Abstract: In recent years, many studies have highlighted the consistent finding of amoxicillin in waters destined for wastewater treatment plants, in addition to superficial waters of rivers and lakes in both Europe and North America. In this paper, the amoxicillin degradation pathway was investigated by simulating the chlorination process normally used in a wastewater treatment plant to reduce similar emerging pollutants at three different pH values. The structures of 16 isolated Citation: Siciliano, A.; Guida, M.; degradation byproducts (DPs), one of which was isolated for the first time, were separated on a Libralato, G.; Saviano, L.; Luongo, G.; C-18 column via a gradient HPLC method. Combining mass spectrometry and nuclear magnetic Previtera, L.; Di Fabio, G.; Zarrelli, A. resonance, we then compared commercial standards and justified a proposed formation mechanism Amoxicillin in Water: Insights into beginning from the parent drug. -
US EPA, Pesticide Product Label, CPPC ULTRA BLEACH 2, 08/29
UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, DC 20460 OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION J Evelyn Lawson Clorox Professional Products Company c/o PS&RC PO Box 493 Pleasanton, CA 94566-0803 Subj ect CPPC Ultra Bleach 2 EPA Registration Number 67619-8 Letter Date August?, 2012 EPA Receipt Date August 8,2012 Dear Ms Lawson This acknowledges receipt of the following notification, submitted in accordance with the provisions of PR Notice 98-10 under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) section 3(c)9 Proposed amendments • Added infant safety pictogram, two new graphics for subregistration use (washing machine), and ingredient disclosure website • Updated EPA Establishment Nos " Corrected a typo at bottom of page 23 General Comments Based on a review of the material submitted, the notification as referenced above is acceptable A copy of the label has been added to the product's file Should you have any questions or comments concerning this letter, please contact Eliza Blair via email at blair ehza(q),epa gov or by telephone at (703) 308-7279 Sincerely, >msha 'n >duct Manager (32) Regulatory Management Branch II Antimicrobials Division (751 OP) Pfetse read instruction* on nvene baton ing form Form Approvr OMB No 2070-006O. Approval expire 2 28 95 United States Registration OPP Identifier Number Environmental Protection Agency Amendment xvEPA EL0459 Washington DC 20460 Other Application for Pesticide - Section I 1 Company/Product dumber 2 EPA Product Manager 3 Proposed Classification 676198 -
Silver As a Drinking-Water Disinfectant
Silver as a drinking-water disinfectant Silver as a drinking-water disinfectant Alternative drinking-water disinfectants: silver ISBN 978-92-4-151369-2 © World Health Organization 2018 Some rights reserved. This work is available under the Creative Commons Attribution- NonCommercial-ShareAlike 3.0 IGO licence (CC BY-NC-SA 3.0 IGO; https://creativecommons.org/licenses/by-nc-sa/3.0/igo). Under the terms of this licence, you may copy, redistribute and adapt the work for non-commercial purposes, provided the work is appropriately cited, as indicated below. In any use of this work, there should be no suggestion that WHO endorses any specific organization, products or services. The use of the WHO logo is not permitted. If you adapt the work, then you must license your work under the same or equivalent Creative Commons licence. If you create a translation of this work, you should add the following disclaimer along with the suggested citation: “This translation was not created by the World Health Organization (WHO). WHO is not responsible for the content or accuracy of this translation. The original English edition shall be the binding and authentic edition”. Any mediation relating to disputes arising under the licence shall be conducted in accordance with the mediation rules of the World Intellectual Property Organization. Suggested citation. Alternative drinking-water disinfectants: bromine, iodine and silver. Geneva: World Health Organization; 2018. Licence: CC BY-NC-SA 3.0 IGO. Cataloguing-in-Publication (CIP) data. CIP data are available at http://apps.who.int/iris. Sales, rights and licensing. To purchase WHO publications, see http://apps.who.int/bookorders.