AKTAIUMIA Akta Kimindo Vol 1January 2016: 1-4 INDONESIA Flavonoid Compounds From The Leaves Of Kalanchoe Tomentosa And Their Cytotoxic Activity Against P-388 Murine Leukemia Cell . l Lilis Siti Aisyah*I,2" Yenny Febriani Yun ,2, Ade Akbar Abdilla \ Tati Herlina', Euis Julaeha', Unang Supratman,**' J Natural Product Chemistry Group, Department of Chemlstry, The Faculty of Mathematics and Natural Sciences, Padjadjaran University, Bandung-Sumedang Km 2 J, Jatinangor, Sumedang 45363 2Department of Chemistry, The Faculty of Mathematics and Natural Sciences, Jenderal Achmad Yani University, Cimahi 40528 Corresponding author: * lies.svarifudin(£i1gmail.com , ** U
[email protected] 3The Faculty of Pharmacy, Jenderal Achmad Yani University, Cimahi 40528 1. INTRODUCTION Abstract Kalanchoe plant, known as "sosor bebek" in Indonesia is a perennial herb and has succulent leaves. Kalanchoe tomentosa belongs to the family The plant is known in folklore and traditional medicine Crassulaceae is a beatiful, perennial and succulent in Indonesia for the treatment of fever, abscesses, plant. Genus Kalanchoe consists of about 130 bruises, contused wounds, coughs and skin diseases. species of annual and perennial shrubs. The plant During the course of our continuing search for novel ussually occur in semi desert of Saudia Arabia, cytotoxic compounds, the methanolic extract of Yemen, CentarlAfrica, Madagascar, tropical areas Kalanchoe tomentosa plants showed cytotoxic activity against P-388 murine leukemia cells. The methanolic of Asia, Australia, and tropical America. extract of the fresh leaves of K. tomentosa was Ussually, it is cultivated as garden ornamental and concentrated and extracted successively with n-hexane, sand gardens with a medium humidity", ethyl acetate and n-butanol.