E SYM Keystone Symposia on Molecular & Cellular Biology N P TO O

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m n e e 40 o t s 2011 Annual Report ing sea July 2010 – June 2011

a 501(c)3 educational nonprofit organization E SYM N P TO O

S S Y I E A he eeting eason

th T 2011 M S

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m October 2010 – June 2011 n e e 40 o t s ing sea Immunological Mechanisms of Vaccination Lung Development and Repair Organizers: Bali Pulendran, Rino Rappuoli and Bruce A. Beutler Oct 27– – Organizers: Brigid L.M. Hogan, Ross Metzger and Edward E. Morrisey TGF-β inNov Immune 1 • Sheraton Responses: Seattle From Hotel Bench• Seattle, to WashingtonBedside • USA ImmunologicFeb 6 11 • Hilton Memory, Santa Fe/Historic Persisting PlazaMicrobes • Santa and Fe, Chronic New Mexico Disease • USA

Jan 7– – Organizers: Wanjun Chen, Howard L. Weiner and Richard A. Flavell Organizers: E. John Wherry, Bali Pulendran and Yasmine Belkaid Functional12 • Snowbird Consequences Resort of• Snowbird, Structural Utah Variation • USA in the Genome AntibodiesFeb 6 11 • Fairmont as Drugs Banff Springs • Banff, Alberta • Canada

Jan 8– – Organizers: Evan E. Eichler and Matthew Hurles Organizers: Nils Lonberg, Stephen M. Ansell and Edith Perez Frontiers13 • ofSheraton NMR in Steamboat Biology Resort • Steamboat Springs, Colorado • USA MicroRNAsFeb 6 11 • Keystone and Non-Coding Resort • Keystone, RNAs and Colorado Cancer • USA

Jan 8– joint with: MicroRNAs and Human Disease Organizers: F. Summers, Dorothee Kern and E. Wemmer Organizers: Gregory J. Hannon, Curtis C. Harris and Martine F. Roussel NK and13 NKT • Big Cell Sky Biology: Resort • BigSpecificity Sky, Montana and Redundancy • USA of Innate Responses – Organizers: Eric N. Olson, Sakari Kauppinen and Eva van Rooij Jan 9– DendriticFeb 11 16 Cells• Fairmont and the Banff Initiation Springs of • Banff,Adaptive Alberta Immunity • Canada Organizers: James P. Di Santo, Eleanor M. Riley and Mitchell Kronenberg Adult 14Neurogenesis • Beaver Run Resort • Breckenridge, Colorado • USA jointOrganizers: with: Cancer Ira Mellman, Control Michel by Tumor C. Nussenzweig, Suppressors Virginia and Immune Pascual Effectors and Federica Sallusto Organizers:Jan 9– Jenny Hsieh, Fred H. Gage, Alejandro Fabian Schinder – and Pierre-Marie Lledo Organizers: Laurence Zitvogel, Anna Karolina Palucka and Mark J. Smyth Histone14 Code:• Sagebrush Fact or Inn Fiction? and Conference Center • Taos, New Mexico • USA InositideFeb 12 17 Signaling • Santa Fe in Community Pharmacology Convention and Disease Center • Santa Fe, New Mexico • USA

Jan 10– joint with: PI 3-Kinase Signaling Pathways Organizers: Karolin Luger, James Davie and Joanna Wysocka Organizers: Marco Falasca, Nullin Divecha, John D. York and Pietro V. De Camilli Type 2 15Diabetes, • Zermatt Insulin Resort Resistance & Spa • Midway, and Metabolic Utah • USA Dysfunction – Organizers: Bart Vanhaesebroeck, Sabina Cosulich and Ramon Parsons joint with: Obesity Genetics,Feb 13 18 Immunology • Keystone Resort and Repair• Keystone, in Multiple Colorado Sclerosis • USA Organizers: Deborah M. Muoio and Rosalind A. Coleman Jan 12– – Organizers: Steven R. Smith and Jacqueline M. Stephens Organizers: Wendy B. Macklin, Gavin Giovannoni and Stephen L. Hauser Tuberculosis:17 • Keystone Immunology, Resort • Cell Keystone, Biology Colorado and Novel • USA Vaccination Strategies NeurodegenerativeFeb 15 20 • Sagebrush Diseases: Inn and Conference Center • Taos, New Mexico • USA The Molecular and Cellular Basis for Neurodegeneration joint with: Mycobacteria: Physiology, Metabolism and Pathogenesis – BackOrganizers: to the StefanBasics H.E. Kaufmann, Gerhard Walzl and Lalita Ramakrishnan – Organizers: Ted M. Dawson, Virginia M.-Y. Lee and Stephen M. Strittmatter Jan 15– MechanismsFeb 21 26 • Sagebrush of Cardiac Inn Growth, and Conference Death and Center Regeneration • Taos, New Mexico • USA Organizers: David R. Sherman and Sabine Ehrt Plant Abiotic20 • Fairmont Stress ToleranceHotel Vancouver Mechanisms, • Vancouver, Water British and GlobalColumbia Agriculture • Canada – Organizers: Richard N. Kitsis, Ivor J. Benjamin and Charles E. Murry Jan 17– MolecularFeb 22 27 •Cardiology: Keystone Resort Disease • Keystone, Mechanisms Colorado and • Experimental USA Therapeutics Organizers: Julian I. Schroeder and Jacqueline E. Heard Epithelial22 •Plasticity Keystone andResort Epithelial • Keystone, to Mesenchymal Colorado • USA Transition – Organizers: M. Metzger, Leslie A. Leinwand and Jeffery D. Molkentin Jan 21– MucosalFeb 22 27 Biology: • Keystone A Fine Resort Balance • Keystone, between Colorado Tolerance • USA and Immunity Organizers: Rik Derynck, Harold A. Chapman and Raymond Runyan Transmembrane26 • Fairmont Signaling Waterfront by GPCRs • Vancouver, and Channels British Columbia • Canada joint with: ImmunityOrganizers: in Joanne the Respiratory L. Viney, Paul Tract: Garside Challenges and Bana of Jabri the Lung Environment Jan 23– Organizers: Oliver P. Ernst and U. Benjamin Kaupp – Extracellular28 • Sagebrush Matrix and Inn Cardiovascularand Conference CenterRemodeling • Taos, New Mexico • USA Organizers: David L. Woodland, Liise-anne Pirofski and Allen G. Harmsen EvolutionaryFeb 26 Mar 3 •Developmental Fairmont Hotel BiologyVancouver • Vancouver, British Columbia • Canada Jan 23– Organizers: Merry L. Lindsey and Thomas K. Borg – The Evolution28 • Granlibakken of Protein Resort Phosphorylation • Tahoe City, California • USA Organizers: Sean B. Carroll, Trisha J. Wittkopp and Nicole King DNAFeb 27 ReplicationMar 3 • Granlibakken and Recombination Resort • Tahoe City, California • USA Jan 23– Organizers: Tony Hunter and Tony Pawson – Stem Cells28 • in Keystone Development, Resort • Tissue Keystone, Homeostasis Colorado • andUSA Disease Organizers: Peter M. Burgers, Lorraine S. Symington and Johannes Walter BiofuelsFeb 27 Mar 4 • Keystone Resort • Keystone, Colorado • USA Jan 30– Organizers: Ronald D. McKay, Elaine Fuchs and Thea D. Tlsty – GenomicFeb Instability 4 • Eldorado and Hotel DNA & Repair Spa • Santa Fe, New Mexico • USA Organizers: Stephen P. Mayfield, Martin Keller and Jeffrey P. Obbard StemMar 1 Cells,6 • Swissôtel Cancer andThe MetastasisStamford • Singapore • Singapore Jan 30– Organizers: Junjie Chen, Karlene A. Cimprich and Michael B. Yaffe –1 Feb 4 • Keystone Resort • Keystone, Colorado • USA Organizers: Richard J. Gilbertson and Daniel A. Haber Mar 6 1 • Keystone Resort • Keystone, Colorado • USA The 2011 season of 55 meetings was the 40th since Keystone Symposia held its first meeting in March 1972 in Squaw Valley, California on membrane research. Keystone Symposia now holds conferences across all facets of the life sciences.

New Frontiers at the Interface of Immunity and Glycobiology

– Organizers: Brian A. Cobb, A. Rabinovich and Yvette van Kooyk AAA+Mar 6 and11 • Related Fairmont ATP-Driven Chateau Lake Protein Louise Machines: • Lake Louise, Structure, Alberta Function • Canada and Mechanism

– Organizers: Andreas Matouschek, Robert T. Sauer and Phyllis I. Hanson MechanismMar 20 24 • andGranlibakken Biology of Resort Silencing • Tahoe City, California • USA

– Organizers: Elisa Izaurralde, Victor Ambros and V. Narry Kim HIVMar Evolution,20 25 • Portola Genomics Hotel &and Spa Pathogenesis • Monterey, California • USA Dr. Chris Wilson of Bill & Melinda Gates Foundation, top left, and Dr. Anthony Fauci of NIAID, NIH, top right, joint with: ProtectionOrganizers: fromMichael HIV: Emerman, Targeted Melissa Intervention Robbiani Strategies () and Amalio Telenti present and attendees interact at the Global Health Series meeting on “Immunological Mechanisms of – Vaccination” in Seattle. Washington in October 2010. Organizers: Mario Roederer, Carolyn Williamson and Robin Shattock MicrobialMar 20 25 Communities • Whistler Conference as Drivers Centre of Ecosystem • Whistler, Complexity British Columbia • Canada

– Organizers: Jacques Ravel, Vincent B. Young, Mitchell L. Sogin and Trina McMahon AutophagyMar 25 30 • Beaver Run Resort • Breckenridge, Colorado • USA

– Organizers: Ana Maria Cuervo, David C. Rubinsztein and Thomas P. Neufeld HematopoiesisMar 27 Apr 1 • Whistler Conference Centre • Whistler, British Columbia • Canada

– Organizers: David Traver, Amy J. Wagers and Emmanuelle Passegué EnvironmentalMar 27 Apr 1 • Big Epigenomics Sky Resort and• Big Disease Sky, Montana Susceptibility • USA

– Participants attend a plenary session at Keystone Organizers: Randy L. Jirtle, Moshe Szyf and Frederick L. Tyson Symposia’s February 2011 “Neurodegenerative MetabolicMar 27 Apr Responses 1 • Grove Park to Extreme Inn Resort Conditions & Spa • Asheville, North Carolina • USA Diseases” meeting in Taos, New Mexico.

Apr 1– Organizers: John R. Speakman, Jan Nedergaard and Sandra L. Martin Immunoregulatory5 • Big Sky Resort Networks • Big Sky, Montana • USA

Apr 1– Organizers: Dario A.A. Vignali, Steven F. Ziegler and Hilde Cheroutre Drugs 6from • Beaver Bugs: Run The Resort Anti-Inflammatory • Breckenridge, Drugs Colorado of Tomorrow • USA

joint with: EvolvingOrganizers: Approaches Padraic G. Fallon,to Early-Stage Grant McFadden Drug Discovery and Amanda E.I. Proudfoot Fichard

Apr 3– Organizers: Craig W. Lindsley and Linda Brady Closing speaker Dr. Sean Morrison and organizer B Cells:7 New• Snowbird Insights Resort into •Normal Snowbird, versus Utah Dysregulated • USA Function Dr. Daniel Haber take questions at the March 2011 meeting on “Stem Cells, Cancer and Metastasis” in Apr 12– Keystone, Colorado. Organizers: David J. Rawlings, Frances E. Lund, Stuart G. Tangye and John G. Monroe Omics Meets17 • Fairmont Cell Biology Chateau Whistler • Whistler, British Columbia • Canada

– Organizers: Anne-Claude Gavin and Charlie M. Boone LipidMay 8 Biology13 • Alpbach and Lipotoxicity Congress Centrum • Alpbach • Austria Organized in collaboration with Science Foundation Ireland

– – Organizers: Scott A. Summers and Rudolf Zechner PathogenesisMay 15 20 • INEC of Influenza:Ireland’s NationalVirus-Host Events Interactions & Conference Centre • Killarney, Co. Kerry • Ireland Organized in collaboration with The University of Hong Kong as part of its Centenary Celebrations

– Organizers: Siamon Gordon, Malik Peiris and Kanta Subbarao ChangingMay 23 28 Landscape • Sheraton ofHong the Kong Cancer Hotel Genome & Towers • Kowloon, Hong Kong • China Attendees mingle in the springtime Alps at Keystone Symposia’s conference on “Omics Meets Cell Biology” Jun 20– in May 2011 in Alpbach, Austria. Organizers: Lynda Chin, Christoph Lengauer and Michael Stratton 3 25 • Boston Park Plaza & Towers • Boston, Massachusetts • USA From the Chair of the Board

As I reflect on the 2011 fiscal year and meeting season – Keystone Symposia’s 40th, I am honored to be associated with Keystone Symposia on Molecular and Cellular Biology and particularly to lead its Board of Directors. This past year, an outstanding array of meetings was offered that continued our reputation for high quality and innovation. In addition, several new initiatives were launched.

For example, in 2011, Keystone Symposia expanded its diversity efforts with the launch of an Early-Career Investigator Travel Award, a Scholars Program for aspiring researchers at the undergraduate“Changing Landscape level piloted of the Cancerat the University Genome” of New Mexico–Taos, and a Health Disparities Workshop, which ran for the first time at our conference on in Boston, Massachusetts. These two initiatives, described in more detail on page 7 of this Annual Report, were greeted with enthusiasm and strong interest, and I am pleased that we will continue and expand them during the 2012 fiscal year, thanks to support from Novartis Institutes for BioMedical Juleen R. Zierath, Ph.D. Research. Corporate gifts such as this enhance our overall diversity program, which is currently supported by a grant from the National Institute of General Medical Sciences of the National Institutes of Health.

These new initiatives are examples of what the valuable gifts provided by government, foundation, corporate and individual partners can make possible. We are grateful for all support during these challenging economic times. In addition to making new programs possible, these gifts help offset the costs associated with holding meetings, and also allow the younger generation of life scientists to participate.

As in past years, the 2011 season meetings involved participation from an outstanding number of these younger scientists (41% of all attendees were students and postdoctoral fellows), and a record number of abstracts were submitted for the meetings as well. There was also an increase in representation from early-career (assistant professor and younger investigator) scientists: as speakers up 97% over three years from 64 in 2008 to 130 in 2011, and as overall attendees up 49% from 941 in 2008 to 1,403 in 2011. This was a very positive trend that we hope will continue.

While most gift and grant support is allocated for scholarships and non-corporate speaker travel expenses, we are always eager to hear your ideas for newwww.ksgift.org programs which. support might enable. We have recently launched a planned giving program for those who might wish to consider supporting Keystone Symposia on an individual basis, details of which can be viewed at

As we officially celebrate the organization’s 40th anniversary in 2012, we thank you for the many ways you have supported Keystone Symposia over the years. We eagerly look forward to the future of accelerating life science discovery and bringing together the scientific community.

Sincerely,

Juleen R. Zierath, Ph.D. Professor of Molecular Medicine and Surgery, Karolinska Institutet Chair of the Board, Keystone Symposia 4 From the Chief Executive Officer

he 2011 meeting season (fall 2010 through spring 2011) was my eighth as CEO of Keystone Symposia, and it was going to be my last until I decided that I was having too much fun to retire. The year did, however, turn out to be an important one for leadership changes. Andy Robertson, our Chief Scientific Officer for more than five years, left to take up responsibility for EMBL’s conferences and educational programs. Fortunately, we found an excellent new CSO, David L. Woodland, Ph.D. (see more on this on the next page), in time to lead us into the 2012 season of scientific conferences. TAssessing any impact of the recession on our meetings is difficult. Overall attendance rebounded in 2011 to near-record levels, reversing the dip of about 12% we experienced in 2010. However, our surveys indicate that starting in 2009, and continuing through 2011, scientists are attending a smaller number of total meetings (of all types) each year. These data reinforce the importance to Keystone Symposia of delivering the highest-quality programming for James W. Aiken, Ph.D. attendees and creating the most favorable atmosphere for valuable face-to-face interactions. Indeed, in 2011, attendees rated Keystone Symposia’s “Overall Scientific Content” and “Scientific Value Compared to Other Meetings” the highest they have been in the past five years. Although this feedback makes me personally very pleased, the credits belong to the Scientific Advisory Board who select topics and recommend organizers, the Scientific Organizers who design the programs and select the speakers, and the Keystone Symposia staff who implement the conferences and make them hospitable.

Also in 2011, we “bit the bullet” and raised the dollar amount of scholarships to $1,200, which had been at $1,000 for a decade, knowing that this move would reduce the total number of scholarships that we could award. The pleasant surprise was that the 20% increase in the value of the scholarship was accompanied by only a 5% decline in the number that we were able to award. The discrepancy was due to increased grant support for scholarships that nearly offset the potential impact of a boost in scholarship value on the number awarded.

Finally, each year we try some new things: novel topics or pairings of joint meetings, global venues, city venues, programming of ancillary workshops on related themes, activities to enhance the participation and value for early-career scientists. For example, in 2011 we held very well-attended meetings in Seattle and Boston, our first meeting in Hong Kong, a novel pairing of a tumor immunology meeting with our dendritic cells meeting, and a new “Health Disparities Workshop.” None of these “experiments” can be evaluated like a laboratory experiment because we can’t control all the variables. Thus, we greatly value the opinions attendees provide to us. This feedback helps us shape new ways to make our symposia more valuable to participants. In 2012 we will try some more “experiments” and look forward to your input.

Thank you to everyone who contributes to Keystone Symposia. We would not be able to accomplish our mission without your invaluable support.

James W. Aiken, Ph.D. President and Chief Executive Officer, Keystone Symposia

5 New Chief Scientific Officer Appointed

by Yvonne Psaila, Director of Marketing and Communications, Keystone Symposia

r. David L. Woodland was appointed Chief Scientific Officer of Keystone Symposia during the summer of 2011. He replaced Dr. Andrew Robertson, who left the organization after five years to become Scientific Coordinator for the EMBL (European Molecular Biology Laboratory) International Center for Advanced Training (EICAT) in Heidelberg, Germany. Woody, as he is known, began his new appointment October 31, 2011.

An internationally recognized lung researcher, immunologist and virologist, Dr. Woodland was previously the President and Director of the Trudeau Institute, aD nonprofit, biomedical research institute located in Saranac Lake, New York. As its head from 2008 to 2011, he directed a staff of more than 100 researchers and administrators and managed a budget of $17 million.Viral Immunology, serves on Biology Direct European Journal Dr.of Immunology Woodland is and Editor-in-Chief is a of the journal . the editorial boards of the journals and the David “Woody” Woodland, Ph.D. member of the American Association of Immunologists He has published close to 200 research articles and reviewed many others during the course of his career.

“I am thrilled to be part A native of the United Kingdom, Dr. Woodland is no stranger to Colorado. After of a highly respected receiving his Bachelor’s degree from the University of Bath in England and then organization that plays a doctoral degree for studies at the Max Planck Institute for Immunobiology in such a pivotal role in Freiburg, Germany, he embarked on a postdoctoral fellowship at National Jewish life science research Health in Denver for four years. Next, he served on the research staff of St. Jude and advancement. The Children’s Research Hospital in Memphis, Tennessee for nine years before joining position as Keystone the Trudeau Institute in 1999. While at St. Jude’s, Dr. Woodland taught as an Symposia’s Chief adjunct professor at the University of Tennessee, Knoxville. Scientific Officer enables me to assume a broader Woody is also no stranger to Keystone Symposia, having organized two Keystone scientific perspective Symposia scientific conferences “Immunityand presented in the at Respiratory numerous others.Tract: Challenges In February of than I have had as a 2011,the Lung he Environment,”was the lead scientific organizer for Keystone Symposia’s conference in specialized researcher, Vancouver,“Mucosal Biology: British A Columbia Fine Balance on between Tolerance and Immunity.” or as the head of a which was held jointly with a Global Health meeting on research institute. I am “Viral Immunity Well and before Host particularly looking Genethe search Influence” for a new Chief Scientific Officer began, he had also been invited to forward to the impact speak at Keystone Symposia’s March 2012 meeting on I can have on scientific at Keystone Resort. communication and training that are central Woody is married to Dr. Marcy Blackman, another noted scientific researcher. to Keystone Symposia’s They actually met while they were postdoctoral fellows in Denver. Along with mission.” their children, she has relocated to Colorado with him and will be continuing her research from Summit County, Colorado. – David “Woody” Woodland In his free time, Woody enjoys jogging, skiing and playing chess. He is also looking forward to getting involved in the local community.

The staff and board of Keystone Symposia warmly welcome Woody and wish him great success in his new role.

6 New Initiatives in 2011

Neurobiologists meet undergraduate University of number of exciting initiatives took shape in the 2011 fiscal New Mexico–Taos biology students during Keystone A Symposia’s February 2011 “Neurodegenerative year and meeting season. Many of these involved new diversity- Diseases” conference in Taos, New Mexico in the pilot focused programs. “Multiple Sclerosis” and Keystone Symposia Scholars Program. “Neurodegenerative Diseases” At the February 2011 conferences on Keystone Symposia Scholars in Taos, New Mexico, Keystone Symposia piloted what has since been named the program. This enables promising undergraduates (in this case from the University of New Mexico–Taos, a minority-serving institution) to take an intensive, tutorial-style class centered around readings of work to be presented at the conference. The class culminates with the students attending the conference and being able to interact first-hand with the researchers whose work they have been reading. Led by Dr. Martinez Hewlett, the course was praised as an extremely valuable experience for all involved. We are grateful for the support that Novartis Institutes for BioMedical Research has pledged for the continuation Dr. Laina King, Director of Diversity in Life Science and expansion of this valuable mentoring program. The initiative Programs at Keystone Symposia, announces the two addtiionally includes a free public lecture for the community, which winners of the 2011 Keystone Symposia/ABRCMS Travel Awards at the Annual Biomedical Research in 2011 was generously given by Dr. Lee Hood at the Harwood Museum Conference for Minority Students in November 2010 in Taos and attended by nearly 100 people. in Charlotte, North Carolina. Health Disparities Workshop Novartis Institutes for BioMedical“Changing Research willLandscape also be of supporting the Cancer Genome”an expansion of a program piloted at Keystone Symposia’s meeting on in Boston, Massachusetts in June 2011. This workshop seeks to promote a better understanding among bench researchers of disparities in medical conditions, genetic predispositions and, in turn, therapeutic solutions for individuals from different ethnic and socioeconomic backgrounds. Similar workshops will be held at three distinct Keystone Symposia conferences in the 2012 meeting season and will also be filmed for broader dissemination via the Internet.

Thanks to funding from the MARC (Minority Access toEarly-Career Research Keystone Symposia graduated its third class of Fellows InvestigatorCareers) grant Travel Keystone Award Symposia received in 2010 from the NIH at the June 2011 Scientific Advisory Board meeting in National Institute of General Medical Sciences, a new Keystone, Colorado. The Fellows program continues was introduced in 2011 for Assistant strong as a key Diversity in Life Science initiative. Professor-level faculty from Underrepresented Minority (URM) backgrounds to attend Keystone Symposia meetings of their choice beginning with the 2012 meeting season. We plan to make at least seven awards in 2012 to early-career faculty who can clearly articulate how attending the conference might help them answer a particular research question, and who agree to mentor a URM student or postdoc for one year. The MARC grant has also enabled Keystone Symposia to offer an expanded number of scholarships to graduate students and postdoctoral fellows from underrepresented minority backgrounds.

Finally in 2011, with its lease nearly up, Keystone Symposia moved Keystone Symposia moved to newly renovated, to newly renovated, leased office space on the second floor of a modern office space in Silverthorne, Colorado in May Silverthorne, Colorado bank building. While just across Highway 6 2011. Like the previous space, the offices sit in the from the previous space, the modern offices facilitate greatly enhanced shadows of the Rocky Mountains’ Gore Range. communication and productivity for the 30-plus-member staff. 7 2011 by the Numbers

Please visit www.keystonesymposia.org/AboutUs/AnnualReport.cfm he charts below are intended to provide a snapshot of Keystone Symposia’s 2011 finances and activities. to view the full audited statement 2011 Expof financialenditur conditione Breakdown and statement of activities for the fiscal year July 1, 2010 – June 30, 2011.

Management & General (12.16%)

Fundraising & Development (3.39%) A full 84.5% of Keystone T Symposia’s expenditures go toward educational programs including meeting programs, scholarships, travel awards and diversity initiatives.

Educational Programs (84.5%)

2011 Revenue Breakdown

Investment Income/ Miscellaneous Income (12.48%)

Individual Gifts (.36%)

Government Grants (6.37%)

Corporate/Foundation Gifts (15.82%)

Registration Fees/ Earned Income (64.97%)

8 Total Meeting Attendance & Abstract Submissions*

13,956 13,509 13,554 13,770 13,015 12,303 11,512 11,222 10,329

Attendees & Speakers 7,340 7,381 6,857 6,587 6,547 5,736 5,962 Abstract Submissions* 5,060 5,400

*abstract count does not include speaker abstracts

2003 2004 2005 2006 2007 2008 2009 2010 2011

Agvera e Attendance & Abstracts* per Meeting

262 270 252 250 244 241 242 241 237 Average Attendance

Average Number of Abstracts* 134 123 130 132 122 127 126 117 110 Number of Meetings

54 56 58 52 55 *abstract count does not 41 46 44 50 include speaker abstracts

2003 2004 2005 2006 2007 2008 2009 2010 2011

Scholarships & Travel Awards 929 930 903 882*

711 681 619 Scholarships 546 Underrepresented 459 Minority Scholarships

Global Health Travel Awards

2003 2004 2005 2006 2007 2008 2009 2010 2011* *Scholarship amount was increased from $1,000 to $1,200 in the 2011 season, which slightly reduced the total number awarded. 9 2011 by the Numbers (continued)

PARTICIPATION OF THE NEXT GENERATION OF INVESTIGATORS (absolute numbers & PERCENT OF TOTAL) 5,654 5,368 5,415 (41%) (39%) (40%) 4,930 (40%) Assistant Professor & Young Investigator Speakers & Organizers

Total Assistant Professor & Young Investigator Attendees

Total Student & Postdoctoral Fellow Attendees 1,403 1,143 1,104 (10%) 941 (8%) (9%) (7%)

64 109 92 130 (4%) (7%) (7%) (9%)

2008 2009 2010 2011 MEETING “EXCELLENT” RATINGS AS a PERCENT OF ALL RATINGS (based on attendee surveys)

60% Overall Scientific Content Quality 55% ScientificV alue Compared to Other Meetings

50% Quality of Plenary Speakers

45%

40% Poster/Abstract Quality 35%

30%

25%

20% 2007 2008 2009 2010 2011

VALUE PARTICIPANTS GAINED FROM THE 2011 MEETINGS (based on attendee surveys)

56% 58%

Strongly Agree

41% Somewhat Agree 36% 35% 33% 33% Neutral 30% 29% Somewhat Disagree

18% Strongly Disagree

10% 5% 4% 3% 2% 1% 1% 1% 1% 0%

Made a Useful Contact Saved Research Time/Money or Meeting Facilitated Learned a Usable Idea Accelerated Research Objective Junior–Senior Interactions or Technique (N=5,103) (N=5,107) (N=5,133) (N=5,131) 10 Donor Support

eystone Symposia is fortunate to receive substantial ongoing support from the pharmaceutical and biotechnology industries, charitable foundations and individuals. We are also honored to be the recipient of numerous grants from the US National Institutes of Health and other government agencies around the world. These gifts and grants are used to provide scholarships for graduate students and postdoctoral fellows, travel awards for scientists from developing nations, and subsidies for the travel and lodging costs of scientific speakers from academic and other nonprofit laboratories and institutions.$4.4 million

For the 2011 meeting season and fiscal year, we received a total of from government, corporate, Kfoundation and individual sources, as shown in the chart below. This funding is crucial in supporting Keystone Symposia’s mission to serve as a catalyst for the advancement of biomedical and life sciences and to accelerate applications that benefit humankind. Individual Gifts: $37,989 (1%)

In-Kind Gifts: $856,806 Corporate Gifts: (20%) $1,172,242 (27%)

Other Government Grants: $318,771 (7%)

US Federal Government Grants: $933,941 Foundation Gifts: (21%) $1,072,386 (24%)

Keystone Symposia gratefully acknowledges donors who gave in the 2011 fiscal year. Their generous support 970.262.1474makes possible the [email protected] scientific quality of our meetings and unsurpassed opportunities for interaction and collaboration among participants. To make awww.keystonesymposia.org/ScienceFund gift, please contact the Development office by. And telephone please visitat our www.ksgift.org or by e-mail at . “Future of Science Fund” individual donations can also be made over the Internet at new website, , for more information on planned giving opportunities and becoming a member of The Keystone Society. This site also provides the opportunity to honor a mentor or loved one via a named fund.

Christopher Atwood, D.Min. Director of Development, Keystone Symposia

11 Donor Support (continued)

Note: The listings on this page and the next five pages reflect donations for the fiscal year beginning July 1, 2010 and ending June 30, 2011.

SUSTAINING BENEFACTORS Donors making a three-year commitment of at least $50,000 per year. Their generous support is crucial to sustain Keystone Symposia’s ability to plan future scientific conferences focused on emerging topics and excellence in science.

Agency for Science, Technology and Research (A*STAR) Bayer USA Foundation Bill & Melinda Gates Foundation National Institute of Diabetes and Digestive and Kidney Diseases, NIH National Institute of General Medical Sciences, NIH, Minority Access to Research Careers (MARC) Science Foundation Ireland BETakedaNEFACT PharmaceuticalORS Company Limited Donors of $50,000 or above. We are very grateful for their extraordinary commitment to our mission to connect the scientific community and accelerate discoveries that benefit society. Special thanks to those organizations that provide consistent, annual Benefactor-level support.

Educational donation provided by Amgen Inc. Genentech, Inc. Merck & Co., Inc. Novartis Institutes for BioMedical Research Novo Nordisk A/S Office of AIDS Research, NIH SUSTAININGPfizer Inc. SPONSORS Donors making a three-year commitment of $25,000 to $49,999 per year. Their generous support is crucial to Keystone Symposia’s ability to plan future scientific conferences focused on emerging topics and excellence in science.

Abbott Laboratories Alnylam Pharmaceuticals, Inc. Astellas Pharma Inc. Celgene Corporation Genzyme Corporation Gilead Sciences, Inc. Hoffmann-La Roche, Inc. Novartis Institutes for BioMedical Research Onyx Pharmaceuticals, Inc. Regulus Therapeutics Inc. Sangamo BioSciences, Inc. SPONSORSSingapore Tourism Board Donors contributing $25,000 to $49,999. These generous gifts allow us to convene meetings in a wide variety of important areas. Special thanks to those organizations that provide consistent, annual Sponsor-level support.

AstraZeneca Pharmaceuticals, L.P. Isis Pharmaceuticals, Inc. Bristol-Myers Squibb Company Johnson & Johnson Pharmaceutical Research & Development, L.L.C. Burroughs Wellcome Fund Monsanto Company Educational grant from Lilly USA, LLC National Multiple Sclerosis Society GlaxoSmithKline Sanofi US ImClone Systems Corporation Teva Pharmaceuticals

12 “As a scientist and member of the biotech industry, I highly value the Keystone Symposia as one of the last venues of true open scientific dialogue spanning both academia and industry in the biological sciences, and am happy to be able to support this work.” – Daniel A. Elkes, Ph.D., Chief Grants Officer, The Elkes Foundation (2012 donor)

DIRECTORS’ FUND BENEFACTORS The following donors with unrestricted gifts of $50,000 or more enabled Keystone Symposia’s President/CEO and Directors to schedule meetings in a variety of important areas, many of which are in the early stages of research.

Educational donation provided by Amgen Novo Nordisk A/S Genentech, Inc. Pfizer Inc. Merck & Co., Inc. Takeda Pharmaceutical Company Limited DIRNovartisECTORS Institutes’ FUND for SPONSORS BioMedical Research The following donors with unrestricted gifts from $25,000 to $49,999 also provided invaluable support to the Directors’ Fund.

Abbott Laboratories Hoffmann-La Roche, Inc. Alnylam Pharmaceuticals, Inc. Isis Pharmaceuticals, Inc. Astellas Pharma Inc. Johnson & Johnson Pharmaceutical Research Bayer USA Foundation & Development, L.L.C. Bristol-Myers Squibb Company Monsanto Company Celgene Corporation Onyx Pharmaceuticals, Inc. Educational grant from Lilly USA, LLC Regulus Therapeutics Inc. Genzyme Corporation Sangamo BioSciences, Inc. Gilead Sciences, Inc. Sanofi US DIVGlaxoSmithKlineERSITY PROGRAM SUPPORT Keystone Symposia is grateful to the following 2011 supporters of its Diversity in Life Science Programs.

Amgen Inc. National Institute of General Medical Sciences (NIGMS), PARTNNovartisERS Institutes, PATRONS for BioMedical, DONORS ResearchAND CONTRIBUTORS NIH, Minority Access to Research Careers (MARC) Keystone Symposia wishes to thank the following donors to the 2011 meeting series. Their generous support makes possible the outstanding scientific quality of our meetings and unsurpassed opportunities for interaction among attending scientists.

PARTNERS ($10,000–$24,999)

Alberta Innovates – Health Solutions, Funded by the Alberta Gordon and Betty Moore Foundation Heritage Foundation for Medical Research Endowment Fund Landes Bioscience* BioMarin Pharmaceutical Inc.* March of Dimes Foundation Boehringer Ingelheim Pharmaceuticals, Inc.* Rete Mirabile Fund of Triangle Community Foundation PACellTRONS Signaling Technology, Inc. ($5,000–$9,999)

Agilent Technologies* Novus Biologicals, Inc.* Avanti Polar Lipids, Inc. Pfizer Oncology* BD Biosciences Rigel Pharmaceuticals, Inc.* Boehringer Ingelheim Stiftung SAIC* Cephalon Santaris Pharma A/S CovX Research LLC (Pfizer) Seahorse Bioscience, Inc. Crohn’s & Colitis Foundation of America STEMCELL Technologies, Inc.* Fáilte Ireland The Company of Biologists Ltd Integrated DNA Technologies* The Ellison Medical Foundation *IndicatesJDRF a gift to the Directors’ Fund, which allows Keystone Symposia’s President/CEO and Directors to schedule and support meetings in the early stages of research.

13 Donor Support (continued)

PARTNERS, PATRONS, DONORS AND CONTRIBUTORS (continued)

DONORS ($2,500–$4,999)

Aastrom Biosciences, Inc. AdipoGen International* Evogene Ltd. Affymetrix, Inc. Found Animals’ Michelson Prize & Grants ALPCO Diagnostics in Reproductive Biology Alzheimer’s Drug Discovery Foundation Intellikine, Inc.* Anita Roberts Memorial Fund iPierian, Inc.* BASF Corporation* ISOTEC, a member of the Sigma-Aldrich Group* Biogen Idec miRagen Therapeutics* Biospherix, Ltd.* OncoMed Pharmaceuticals, Inc.* BioVentures, Inc.* Promega Corporation* Boston Biochem, Inc.* Rules-Based Medicine, Inc.* Bruker BioSpin Corp.* Santa Cruz Biotechnology, Inc.* Cambridge Isotope Laboratories* Stemgent* The Journal of CEDARLANE* Syngenta Cell Biology Biotechnology, Inc.* Development,ChemoCentryx, Inc.* The Rockefeller University Press – The Journal of Chroma Technology Corporation* Experimental* Medicine The Company of Biologists Ltd The Rockefeller University Press – Educational grant from Millennium Pharmaceuticals, Inc., * The Takeda Oncology Company CONTRIBUTORS (up to $2,499)

American Heart Association’s Council on Basic Mizutani Foundation for Glycoscience Cardiovascular Sciences New England Biolabs, Inc.* Autism Speaks New Era Enterprises, Inc. Biosensis Pty Ltd Pioneer Hi-Bred a DuPont business GrassRoots Biotechnology sanofi pasteur JournalHatteras of Instruments, Lipid Research Inc. Society of Toxicology Illumina, Inc. Takeda San Diego University of Texas Medical Branch (UTMB) Health Kent Scientific Corporation US GOVERNMENT GRANTS Keystone Symposia appreciates grants to support various 2011 meetings received from the following government agencies.

National Institutes of Health (NIH): National Cancer Institute (NCI) National Human Genome Research Institute (NHGRI) National Heart, Lung, and Blood Institute (NHLBI) National Institute on Aging (NIA) National Institute of Allergy and Infectious Diseases (NIAID) Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) National Institute of Dental and Cranofacial Research (NIDCR) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) National Institute of Environmental Health Sciences (NIEHS) National Institute of General Medical Sciences (NIGMS) National Institute of Mental Health (NIMH) National Institute of Neurological Disorders and Stroke (NINDS) *IndicatesNational a Science gift to the Foundation Directors’ Fund, (NSF) which allows Keystone Symposia’s President/CEO and Directors to schedule and support meetings in the early stages of research.

14 Keystone Symposia Future of Science Fund

The following generous alumni of previous meetings and others with a passion for ensuring a future of scientific discovery that benefits humankind have made gifts in the fiscal year ending June 30, 2011 to support the Keystone Symposia Future of Science Fund. Through their generosity, we are able to provide scholarships and travel awards to the next generation of biomedical and life scientists, whose education and careers are enhanced by the opportunity to attend meetings and interact with the world’s leading senior scientists.

In addition to funding general and underrepresented minority scholarships and travel awards for investigators originating from countries most affected by topics of specific meetings, Future of Science Fund supporters can also contribute to help us meet general conference program expenses, as well as program costs for specific meetings of their choice.

President’s Circle ($10,000+) Keystone Patrons ($100–$499) Keystone Patrons (continued)

Founders’ Society ($5,000–$9,999) Alan D. Attie, in memory of Roger A. Davis Alberto Bosque Heber C. Nielsen Cherié L. Butts Donal O’Gorman Keystone Champions ($1,000–$4,999) Hannah V. Carey Jose Luis Olmos Serrano Andre C. Carpentier Marc A. Prentki Wen Chang, in memory of Frank Fenner Denise Silva Rodrigues Jim Aiken Ming Chen Nuri Rodriguez Del Val Kenneth W. Bair Priscilla Pui Lam Chiu Edward B. Sanders Edward A. Dennis Maria Valeria Corrias Hidetaka Sato Vishva M. Dixit Yamini Dalal Alan Sher Raymond N. DuBois Robert A. Davey Jill E. Slansky Barrie Hesp, with matching gift from Pfizer Yakhya Dieye Gregory T. Spear Margaret A. Liu, Robert Johnson Bo Dupont Ivan Stamenkovic Walter H. Moos, Susan M. Miller Laurence C. Eisenlohr Ann M. Stock Roy G. Michell Charitable Foundation Lee M. Ellis James W. Thomas and Trust Beverly M. Emerson Chanwit Tribuddharat Sidney E. Frank Foundation Remi Fagard Moriya Tsuji Juleen R. Zierath Adetona Fayemiwo Stella Maris Venturiello, in memory KeyAnonymousstone (1)Benefactors ($500–$999) Ruben Dario Flores-Saaib of Dr. Venturiello, Juan José John F. Foley Joanne L. Viney, with matching gift Stephanie E. Fulton from Amgen Inc. Christopher Atwood Robert G. Griffin Pablo Wappner James L. Bennett, in memory of Hank Harwood Nancy L. Haigwood Thomas E. Wellems Steven Buchsbaum, with matching gift from Masataka Harada Carolyn A. Wilson Bill & Melinda Gates Foundation Matching Marie Hardwick Aprilianto Eddy Wiria Gifts Program Mary J.C. Hendrix Yasuko T. Yokota Robert L. Coffman Shigeyoshi Itohara KeyAnonymousstone (9)Contributors Cintia S. De Paiva Anthony A. James ($10–$99) Ellen M. Gravallese Ryoichiro Kageyama Zdenek Hostomsky, Zuzana Hostomsky, Steven Kerfoot with matching gift from Pfizer Laura L. Kiessling and Ronald T. Raines Nada A. Abumrad Suraj P. Manrao Shohei Koide Yasunori Aizawa Luciano Mueller, with matching gift from Takeshi Kurose Lisa M. Alleva Bristol-Myers Squibb Matching Gift Program Ursula Barbara Kurzik-Dumke Alex Almasan Jeanne M. Nerbonne Carlo Laudanna Samar Alsafadi Terry J. Opgenorth Dezhi Liao Monica William R. Sellers Meei-Yun Lin Nabahet Ameur Ian A. Wilson Patricia J. LiWang Fariba M. Assadi-Porter Daisuke Yamamoto Marcia MacDonald Hyeeun Bang Shi-Yuan (Tina) Meng, with matching gift Stephen H. Bartelmez from Amgen Inc. Helen Benes Jennifer Lynn Milne Helen Benes, in memory Wladek Minor of Helen Dulik Benes Shigeo Murata Fabiana Bigi Robert C. Murphy Bonnie B. Blomberg Masahiro Nakagawa Linda B. Bloom 15 Future of Science Fund (continued)

Keystone Contributors (continued)

Umesh Chandra Katpally Cherylene Plewa, with matching Lisa Borghesi Fujio Kayama gift from Amgen Inc. EzraBryant Burstein B.A. Boulianne John F. Kearney Mette Prætorius-Ibba D. Burgener Laura L. Kiessling Naresh Singh Redhu, Yutaka Kikuchi in honor of Rajbir Singh Redhu Yassemi Capetanaki Cynthia Kim, Dr. Dona Kim Murphey, PhD, MD Vernon Reinhold Linda S. Cauley James I. Kim Charles H. Reynolds Manuela Cernadas Young Min Kim Ian R. Rifkin Zhiyong Cheng Kensuke Kojima John R. Riordan Elena Chertova Shohei Koyama Rodrigo Ferracine Rodrigues Valerio Chiurchiù Tomoko Kozu Derry Roopenian Daniela Cipolletta Igor B. Kramnik Sarah L. Rowland-Jones Alessio Ciulli Brett M. Kroncke Leonardo Sahelijo Paul J. Converse Anna Krook James P. Sainsbury Alejandra Covarrubias Andrew S. Krueger Derek B. Sant’Angelo Melanie Green Cree John E. Lafleur Corrado Santocanale Ruben K. Dagda Emilie Layre Andreas Schaller Pamela S. Daugherty Dong-Sup Lee Marielle Scherrer-Crosbie Hans-Ulrich Demuth Jungwoo Lee Carmen Diana Schweighofer Eric J. Devor Tae Weon Lee, with matching gift Matthew M. Seavey Franck Anicet Ditengou from Amgen Inc. Carl Seguin Surjit B. Dixit Yoo Jeong Lee Erin Leah Seifert Juan Dong Chong Bi Li Kunal Shah Horng-Yunn Dou Zhi-Ping Liu Padubidri Vedavyasa Shivaprasad Irina Dulubova Stavros Lomvardas Jason Shohet Robert H. Eckel Marion Lösing Venkateswara Rao Simhadri Collin L. Ellis Jun Lu Purnima Singh Grigori Enikolopov Steven K. Lundy Nicholas J. Skelton Lluis Fajas Thomas Alexander Lutz Georgi Svetoslavov Slavchev Mogens Fenger Ryan J. Mailloux Sandra C. Souza Pavel Flachs Miyeko D. Mana Celsa A. Spina Stephanie K. Florio Adriana R. Mantegazza Francesca Storici Shaobing Fong Olivia M. Martinez Linda D. Strausbaugh Fedra Francocci Barsanjit Mazumder Shoukichi Takahama, in memory Luca Freschi Kathleen L. McGuire of our wedding 2010. 10. 23 Hidekazu Fujimaki Stuart G. McLaughlin Hisashi Tanaka Deepti Gadi Austen J. Milnerwood Martin P. Tenniswood Stefania Gallucci Keita Miyoshi Clifford Graham Tepper Laura A. Genovesi M. Alexandra Monroy Vladimir I. Titorenko Marvin C. Gershengorn Isabelle Morize Michael Tomasson Don L. Gibbons Tanya Muller Tamotsu Tsukahara Sandra Gonzalez David W. Mullins Cristina Tufarelli, in memory Susana Gonzalo Henry Charles Mwandumba of Dr. Mark Plumb Andrew E. Greenstein Philip M. Mwimanzi Srijayaprakash Uppada Jean-Charles J. B. Grivel Eiichiro Nagata Clarissa Valim Abdoul Karim Guiro Subhadra Nandakumar Astrid M. van der Sar Abdoul Karim Guiro, in memory Arabinda Nayak Prabhakaran Vasudevan of Guiro Abdoul Karim Ralph A. Nixon Sjef Verbeek Stuart J. Haring Ekwaro Obuku, in memory Alfonso Ignacio Vergara Yunlong He of Dr. John Brian Obuku Luis G. Villa-Diaz Joerg Heeren Masaru Ohme-Takagi Charlotte M. Vines Jorge A. Henao-Mejia Sakol Panyim Thomas Vogt David A. Horwitz Christopher Y. Park Burghardt Wittig Linda Hrycaj Rebecca P. Payne Blerta Xhemalce Matthias Husmann Bernard Payrastre Ying Xiong Rahizan Issa Alexander Pedroza-González Kei Yasuda Yuri Ivashchenko Maikel Peppelenbosch Vijay K. Yechoor Mi-Hyeon Jang Gabriela C. Pérez-Alvarado, Noriko Yokoyama Jae-Heon Jeong in memory of Rodrigo Ephrem Debebe Zegeye Zhyldyz Kabaeva Alexander Pertsemlidis Shuo Zhang Pili M. Kamenju Kylee M. Peterson Xiaohui Zhao 16 Sandep Kandhwal, in honor of My Mother Christopher J. Phiel Houjiang Zhou Eunchai Kang Leigh A. Plesniak Anonymous (7) Gift-in-Kind Donor Support

MARKETING/ADVERTISING IN-KIND DONORS The following publishers, societies and other organizations provided in-kind marketing and advertising support that helped publicize the 2011 Keystone Symposia meeting series.

BENEFACTORS ($50,000+) PATRONS (continued)

Cells Tissues Organs BioMed Central Ltd Royal Society ofCytogenetics Chemistry & Genome Research TheCell ScientistPress S. Karger AG – Journal of Molecular Microbiology & Nature Publishing Group S. Biotechnology Karger AG – SPONSORS ($25,000–$49,999) S. Karger AG – Respiration BioTechniques S. Karger AG – The Journal of Cell Biology Springer Science+Business Media B.V. Cold Spring Harbor Laboratory DONORSThe Company ($2,500–$4,999) of Biologists Ltd PARThe TNRockefellerERS ($10,000–$24,999) University Press –

Drug Discovery Today Cell Therapy News American Association for the Advancement of Science Extracellular Matrix News Hematopoiesis News EMBO (European Molecular Biology Organization) Neural Cell News FOCIS (Federation of Clinical Immunology Societies) PortlandCONTRI BPressUTORS Ltd (up to $2,499) Mary Ann Liebert, Inc. Publishers Proceedings of the National Academy of Sciences (PNAS) Pubget Inc. The Journal of AIDS Vaccine Advocacy Coalition S. Experimental Karger AG Medicine Beatson Institute for Cancer Research The Rockefeller University Press – Canadian Society for Life Science Research EpiGenie Wiley-Blackwell PATRONS ($5,000–$9,999) JournalF+L Asia of Clinical Investigation International Society for Stem Cell Research (ISSCR)

American Society for Biochemistry and Molecular Biology The New York Stem Cell Foundation SPPublicEAK ELibraryR GIFT of-IN Science-KIND (PLoS)DONORS The Official Journal of the Institute of Integrative Omics and Applied Biotechnology (IIOAB) The following companies generously agreed to forego reimbursements for speaker travel and lodging expenses in order to support 2011 Keystone Symposia meeting programs.

Abbott Laboratories Genzyme Corporation Alder Biopharmaceuticals, Inc. Geron Corporation Astellas Pharma Inc. GlaxoSmithKline Biologicals AstraZeneca Heptares Therapeutics Ltd AstraZeneca R&D ImmunoGen, Inc. Bayer BioScience N.V. MedImmune Biogen Idec NeuroNovaMerck Vaccine AB Division Brain Cells Inc. Micromet, Inc. Bristol-Myers Squibb Company Calistoga Pharmaceuticals, Inc. Novartis Vaccines and Diagnostics Celldex Therapeutics, Inc. Pfizer Biopharmaceuticals Cosmo Biofuels Group Pfizer Global Research & Development CSL Limited Pfizer Inc. Dynavax Technologies Corporation Procter and Gamble Company Educational donation provided by Amgen Sanofi US Eli Lilly and Company Santaris Pharma A/S EMBO Young Investigator Programme Seattle Genetics, Inc. Epizyme, Inc. Signature Genomics, a PerkinElmer company Genentech, Inc. The Genomics Institute of the Novartis Research Foundation Genmab B.V. 17 Board of Directors (as of Dec. 31, 2011)

Juleen R. Zierath, Ph.D. Margaret A. Liu, M.D. Chair of the Board, Keystone Symposia Chair, Development Committee, Keystone Symposia

Professor,Craig B. Thompson, Molecular MedicineM.D. and Surgery, Karolinska Institutet ProTherImmune;Gary J. Nabel, M.D., Visiting Ph.D. Professor, Karolinska Institutet Secretary of the Board Chair, Scientific Advisory Board, Keystone Symposia Bethesda,Tony Pawson, Maryland Ph.D.

PresidentTerry J. Opgenorth, and CEO, Memorial Ph.D. Sloan-Kettering Cancer Center Treasurer of the Board Senior Investigator Alan Sher, Ph.D. Chair, Finance Committee, Keystone Symposia Centre for Systems Biology, Samuel Lunenfeld Research Institute Chair, Nominating Committee, Keystone Symposia

Chief Operating Officer, NeoTREX Bethesda,Ian A. Wilson, Maryland Ph.D., Sc.D., FRS CSUJames Ventures, W. Aiken, Inc., Ph.D. Colorado State University

Professor, Department of Molecular Biology President and Chief Executive Officer and The Skaggs Institute for Chemical Biology KeystoneKenneth W.Symposia Bair, Ph.D. on Molecular and Cellular Biology Chair, Audit Committee, Keystone Symposia The Scripps Research Institute

Senior Vice President and Head, Research and Development RalphEMERITUS A. Br BOARDadshaw, MEMBERS Ph.D. FormaBeverly Therapeutics, M. Emerson, Inc. Ph.D. Chair, Personnel Committee, Keystone Symposia Professor Emeritus, Physiology and Biophysics College of Medicine, University of California, Irvine Professor, Regulatory Biology Laboratory Professor in Pharmaceutical Chemistry and Deputy Director of ThePeter Salk M. InstituteFinan, Ph.D. MassRobert Spectrometry W. Craig Facility, University of California, San Francisco

Director, Pathways Biology PresidentEdward A. Emeritus, Dennis, Ph.D.The Keystone Center Developmental and Molecular Pathways NovartisHeidi E. Hamm,Institutes Ph.D. for BioMedical Research Professor, Chemistry, Biochemistry and Pharmacology SchoolCurtis C.of Harris,Medicine, M.D University. of California, San Diego Professor and Chair, Department of Pharmacology VanderbiltEdison T. Liu, University M.D. School of Medicine Chief, Laboratory of Human Carcinogenesis Note: All Board and Emeritus Board Members are also members NCI/Nationalof Keystone Symposia’s Institutes Scientific of Health Advisory Board. President and Chief Executive Officer The Jackson Laboratory

Staff Members (as of Dec. 31, 2011)

James Aiken Heather Gerhart Pamela Daugherty Susan Gunn David Woodland, Chief Executive Officer Lindsey Heilmann, Senior Grants Coordinator/Program Analyst Jeannie Dalrymple , Chief Financial Officer Jenny Hindorff, Seasonal Logistics Representative , Chief Scientific Officer Kellan Hoover , Conference Coordinator Linda Hrycaj , Senior Director, Program Development Mike Lachata , Program Implementation Associate & Implementation Christopher Atwood Sarah Lavicka , Marketing Associate , Senior Director, Strategic Planning Heidi Daetwyler-Simpson Jeff Lehman , Information Technology Programmer , Director, Development Laina King Phyllis McNeil, Administrative & Research Assistant, Development , Director, Meeting Management Tanya Muller Allison Ogdon, Scholarship Coordinator , Director, Diversity in Life Science Programs Yvonne Psaila Annie Page , Attendee Services Representative , Director, Information Technology Mary Jo Roal McKennzie Rains, Program Development Coordinator , Director, Marketing & Communications , On-Site Representative David Adamson Representative Grace Roath , Director, Human Resources , IT Support/Assistant Arne Ahlstrom Representative Julie Roll , Office Manager Cathy Banks , On-Site David Sanchez , On-Site Representative Carol Bosserman, On-Site Representative Barbara Schmid-Miller , Manager, Attendee Services Mary Brown, Web Developer/SystemsRepresentative Analyst Gwyn Schmude , Program Implementation Assistant Caroline Brendel, On-Site Dawn Shafer , Attendee Services Representative Melissa Carrera, On-Site, A Bridget Stacy Linda Cooper , Executive Administrative Assistant Kathy Tavares, Accounting Clerk Amanda Deem ssistant Director of Development Rebecca Wilkerson, Administrative Assistant, Diversity , Publications Assistant , Program Development/Implementation Supervisor 18 , Assistant Director of Development , Finance Assistant Scientific Advisory Board (as of Dec. 31, 2011)

E. Dale Abel, M.D., Ph.D. Adolfo Garcia-Sastre, Ph.D. Eric M. Parker, Ph.D.

Professor of Medicine, Biochemistry Professor, Department of Microbiology Senior Director and Neuroscience Site Lead and Human Genetics Co-Director, Emerging Pathogens Institute Neurology Catherine E. Peishoff, Ph.D. Chief, Division of Endocrinology MountTariq Ghayur, Sinai School Ph.D. of Medicine Merck Research Laboratories, Merck & Co., Inc. Metabolism and Diabetes Investigator, Program in Molecular Medicine Vice President Josie I. Johnson Professorship in Molecular Biology Research Fellow Douglas R. Green, Ph.D. Computational and Structural Chemistry Medicine and Biochemistry Abbott Bioresearch Center Ronald T. Raines, Ph.D. Jacques F. Banchereau, Ph.D. GlaxoSmithKline Pharmaceuticals The University of Utah School of Medicine Doherty Chair of Immunology Department of Immunology Professor Senior Vice President and Chief Scientific Officer Philip D. Gregory, Ph.D. Departments of Biochemistry and Chemistry Inflammation and Virology St. Jude Children’s Research Hospital Roger R. Reddel, Ph.D. Stephen L. Brenner, Ph.D. University of Wisconsin–Madison Hoffmann-La Roche Inc. Chief Scientific Officer, Research Diane E. Griffin, M.D., Ph.D. Director Vice President of Molecular Biosciences Sangamo Biosciences, Inc. Juan Rivera, Ph.D. Leslie J. Browne, Ph.D. Children’s Medical Research Institute, Sydney Bristol-Myers Squibb Company Professor and Chair Molecular Microbiology and Immunology Deputy Director, Intraumural Research Program President and CEO Jacqueline E. Heard, Ph.D. Thomas F. Bumol, Ph.D. John Hopkins Bloomberg School of Public Health Chief, Laboratory of Molecular Immunogenetics Senesco Technologies, Inc. and Molecular Immunology Section Nadia A. Rosenthal, Ph.D. NIAMS, National Institutes of Health Vice President, BioTechnology Research Venture Capital Principal Global Strategy and R&D Investment Lilly Research Laboratories Kim A. Heidenreich, Ph.D. Director of EMBL Monterotondo, Mouse Biology Unit President and Site Head, Applied Molecular Evolution, Monsanto Company Andrej Sali, Ph.D. Judith Campisi, Ph.D. European Molecular Biology Laboratory Inc. and Lilly Biotechnology Center – San Diego Professor, Department of Pharmacology Christopher L. Karp, M.D. Professor, Bioengineering and Therapeutic Sciences Professor University of Colorado Denver (UCHSC) Martin Schneider, Ph.D. Arturo Casadevall, M.D. University of California, San Francisco Buck Institute for Research on Aging Professor, Director, Division of Molecular Immunology Elliott D. Kieff, M.D., Ph.D. Cincinnati Children’s Hospital Research Foundation Senior Vice President, Global Therapeutical Research Professor and Chair, Microbiology and Immunology Professor, Global Drug Discovery Hubert C. Chen, M.D. Stephen J. Simpson, Ph.D. Albert Einstein College of Medicine Bayer HealthCare AG Albee Professor Medicine, Microbiology and Molecular Genetics Vice President, Translational Medicine Laura L. Kiessling, Ph.D. Life Sciences Directorate Robert L. Coffman, Ph.D. Harvard University Frank J. Slack, Ph.D. Regulus Therapeutics Inc. Science Foundation Ireland

Vice President and Chief Scientific Officer Hilldale Professor of Chemistry Max D. Cooper, M.D. Professor Dynavax Technologies Laurens Anderson Professor of Biochemistry Department of Chemistry and Biochemistry Molecular Cellular and Developmental Biology Jacqueline Kirchner, Ph.D. Didier Y.R. Stainier, Ph.D. University of Wisconsin-Madison Yale University Georgia Research Alliance Eminent Scholar Professor of Pathology and Laboratory Medicine Alan J. Cross, Ph.D. Scientific Director, Inflammation Professor Emory University School of Medicine Christopher Kirk, Ph.D. Amgen Inc. Department of Biochemistry and Biophysics School of Medicine Eric E. Swayze, Ph.D. Chief Scientist, CNS and Pain Innovative Medicines University of California, San Francisco Manoj C. Desai, Ph.D. Director, Preclinical Research AstraZeneca Pharmaceuticals Jan E. Leach, Ph.D. Onyx Pharmaceuticals, Inc. Vice President, Medicinal Chemistry Doris A. Taylor, Ph.D. Vice President, Medicinal Chemistry Isis Pharmaceuticals, Inc. Vishva M. Dixit, M.D. Gilead Sciences, Inc. University Distinguished Professor Bioagricultural Sciences Karolin Luger, Ph.D. Medtronic Bakken Chair of Physiology and Medicine Colorado State University Vice President, Research Director, Center for Cardiovascular Repair Physiological Chemistry Department of Integrative Biology and Physiology Robert H. Eckel, M.D. Thomas Tuschl, Ph.D. Genentech, Inc. HHMI Investigator and Professor University of Minnesota Department of Molecular Biology and Biochemistry Elizabeth M. McNally, M.D., Ph.D. Colorado State University Charles A. Boettcher Endowed Chair in Atherosclerosis HHMI Investigator and Associate Professor Laboratory of RNA Molecular Biology Professor of Medicine and of Physiology Nicolai R. Wagtmann, Ph.D. Professor, Department of Medicine and Human Genetics The Rockefeller Institute and Biophysics Juanita L. Merchant, M.D., Ph.D. Program Director, Adult GCRC University of Chicago Medicine/Endocrinology Vice President and Head of Inflammation Biology University of Colorado Denver Biopharmaceuticals Research Unit Martin P. Edwards, Ph.D. Departments of Internal Medicine Michael J.O. Wakelam, Ph.D. Anschutz Medical Campus and Molecular and Integrative Physiology Novo Nordisk A/S Tara Mirzadegan, Ph.D. University of Michigan Vice President, Cancer Chemistry Institute Director Lee M. Ellis, M.D. David R. Webb, Ph.D. Pfizer La Jolla Team Leader, Computational Chemistry The Babraham Institute Johnson & Johnson Pharmaceutical Donald W. Nicholson, Ph.D. Professor, Cancer Biology and Surgical Oncology Research & Development, L.L.C. Adjunct Professor, Department of Molecular Biology I. Sadaf Farooqi, Ph.D., FRCP Kenneth F. Wertman, Ph.D. The University of Texas MD Anderson Cancer Center The Scripps Research Institute Vice President, Worldwide Discovery Head, R&I Hiroyuki Odaka, Ph.D. Wellcome Trust Senior Clinical Fellow and Reader in Merck & Co., Inc. Scientific Director, Tucson Human Metabolism, Metabolic Research Laboratories Associate Vice President, Discovery Research Curt R. Freed, M.D. University of Cambridge General Manager, Pharmaceutical Research Division Chemical and Analytical Sciences Anne O’Garra, Ph.D., FRS, FMedSci David L. Woodland, Ph.D. Takeda Pharmaceutical Company Limited Sanofi US Professor and Head

Division of Clinical Pharmacology and Toxicology Head, Division of Immunoregulation Chief Scientific Officer University of Colorado Denver School of Medicine MRC National Institute for Medical Research Keystone Symposia on Molecular and Cellular Biology PO Box 1630 | 160 US Highway 6, Suite 200 Silverthorne, Colorado 80498 | USA 1.970.262.1230 | 1.800.253.0685 www.keystonesymposia.org