Youscript Actionable Medication List

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YouScript Actionable Medication List Surfacing evidence-based drug-gene interaction guidance within the clinical workflow YouScript’s database contains almost 2,000 unique drugs, herbals, and OTC medications and over 90 phenotypes. Our clinical content team continuously evaluates new drugs, research, and data, and created a library of over 17,000 professionally curated published references and product inserts. Actionable Drug-Gene Interactions The table below is a targeted list totaling 138 drugs within YouScript which contain a defined, actionable drug-gene interaction. For a comprehensive list of drugs with any drug-gene interaction, contact us at [email protected]. abacavir daclatasvir fluorouracil nefazodone amitriptyline dapsone fluoxetine nilotinib arformoterol darifenacin flurbiprofen nitrofurantoin aripiprazole dasabuvir / ombitasvir / fluvoxamine nortriptyline aripiprazole lauroxil paritaprevir / ritonavir formoterol olaparib atomoxetine desipramine galantamine olaratumab avelumab desvenlafaxine glimepiride ombitasvir / paritaprevir azathioprine deutetrabenazine glipizide / ritonavir belinostat dexlansoprazole iloperidone omeprazole blinatumomab dextromethorphan / imipramine ondansetron boceprevir quinidine indacaterol oxcarbazepine brexpiprazole diazepam irinotecan palonosetron brivaracetam dolutegravir isoniazid / pyrazinamide pantoprazole capecitabine donepezil / rifampin paroxetine carbamazepine doxepin isosorbide mononitrate pazopanib cariprazine dronabinol lacosamide peginterferon alfa-2b carisoprodol drospirenone / ethinyl lansoprazole pegloticase carvedilol estradiol ledipasvir / sofosbuvir perphenazine celecoxib duloxetine lesinurad phenytoin cevimeline efavirenz mafenide pimozide chloroquine elbasvir / grazoprevir mercaptopurine piroxicam chlorpropamide eltrombopag methylene blue prasugrel cisplatin erythromycin metoclopramide probenecid citalopram ethylsuccinate / metoprolol propafenone clobazam sulfisoxazole acetyl mirabegron propranolol clomipramine escitalopram modafinil protriptyline clopidogrel esomeprazole moviprep quinidine clozapine fesoterodine nalidixic acid quinine codeine flibanserin nebivolol rabeprazole Reviewed: 6/20/2019 Safer Medication Management Begins With You rasburicase risperidone rosuvastatin simeprevir simvastatin sodium nitrite sofosbuvir sofosbuvir / velpatasvir sofosbuvir / velpatasvir / voxilaprevir succimer sulfadiazine sulfamethoxazole / trimethoprim sulfasalazine tamoxifen tamsulosin telaprevir tetrabenazine thioguanine thioridazine ticagrelor tolterodine tramadol trimipramine umeclidinium valbenazine venlafaxine voriconazole vortioxetine warfarin __________ Total: 138 drugs Reviewed: 6/20/2019 www.YouScript.com | 877.796.4362.

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Pindolol of the Activation of Postsynaptic 5-HT1A Receptors
Potentiation by (-)Pindolol of the Activation of Postsynaptic 5-HT1A Receptors Induced by Venlafaxine Jean-Claude Béïque, Ph.D., Pierre Blier, M.D., Ph.D., Claude de Montigny, M.D., Ph.D., and Guy Debonnel, M.D. The increase of extracellular 5-HT in brain terminal regions antagonist WAY 100635 (100 ␮g/kg, i.v.). A short-term produced by the acute administration of 5-HT reuptake treatment with VLX (20 mg/kg/day ϫ 2 days) resulted in a inhibitors (SSRI’s) is hampered by the activation of ca. 90% suppression of the firing activity of 5-HT neurons somatodendritic 5-HT1A autoreceptors in the raphe nuclei. in the dorsal raphe nucleus. This was prevented by the The present in vivo electrophysiological studies were coadministration of (-)pindolol (15 mg/kg/day ϫ 2 days). undertaken, in the rat, to assess the effects of the Taken together, these results indicate that (-)pindolol coadministration of venlafaxine, a dual 5-HT/NE reuptake potentiated the activation of postsynaptic 5-HT1A receptors inhibitor, and (-)pindolol on pre- and postsynaptic 5-HT1A resulting from 5-HT reuptake inhibition probably by receptor function. The acute administration of venlafaxine blocking the somatodendritic 5-HT1A autoreceptor, but not and of the SSRI paroxetine (5 mg/kg, i.v.) induced a its postsynaptic congener. These results support and extend suppression of the firing activity of dorsal hippocampus CA3 previous findings providing a biological substratum for the pyramidal neurons. This effect of venlafaxine was markedly efficacy of pindolol as an accelerating strategy in major potentiated by a pretreatment with (-)pindolol (15 mg/kg, depression.
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Anaesthesia and Past Use Of
177 Correspondence were using LSD. It is more popular than other commonly Anaesthesia and past use of used hallucinogens whose quoted incidence of clients are: LSD ketamine 0.1% (super-K/vitamin K.I), psilocybin and psilocin 0.6% (the active alkaloids in the Mexican "magic To the Editor: mushroom"), and 3,4 methylenedioxymethamphetamine We report the case of a 43-yr-old lady who was admitted ~MDMA" 1% (ecstasy). The effects of the concurrent to the Day Surgery Unit for release of her carpal tunnel ingestion of LSD on anaesthesia are well described. 2-4 retinaculum. During the preoperative visit, she reported The long-term effects of the past use of LSD are largely no intercurrent illnesses, drug therapy or allergies. She unknown. We wonder if the hallucinations experienced did say, however, that she was frightened of general anaes- by our patient during anaesthesia were due to her LSD thesia, since she had experienced terrifying dreams during intake many years before. We would be interested to surgery under general anaesthesia on three occasions dur- know if others have had experience anaesthetising patients ing the previous ten years. On further questioning, she who are past users of phencyclidine-derived drugs. admitted that she had used lysergic acid diethylamide (LSD) during the late 1960's, the last occasion being 1968 Geoffrey N. Morris MRCGPFRCA when she had experienced characterstic hallucinations. Patrick T. Magee MSe FRCA She had not experienced hallucinations in the ensuing Anaesthetic Department years, except on the surgical occasions mentioned. Royal United Hospital One of the three previous operations had been per- Combe Park formed at our hospital and the anaesthetic record was Bath BA1 3NG checked.
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Drug Class Review Beta Adrenergic Blockers
Drug Class Review Beta Adrenergic Blockers Final Report Update 4 July 2009 Update 3: September 2007 Update 2: May 2005 Update 1: September 2004 Original Report: September 2003 The literature on this topic is scanned periodically. The purpose of this report is to make available information regarding the comparative effectiveness and safety profiles of different drugs within pharmaceutical classes. Reports are not usage guidelines, nor should they be read as an endorsement of, or recommendation for, any particular drug, use, or approach. Oregon Health & Science University does not recommend or endorse any guideline or recommendation developed by users of these reports. Mark Helfand, MD, MPH Kim Peterson, MS Vivian Christensen, PhD Tracy Dana, MLS Sujata Thakurta, MPA:HA Drug Effectiveness Review Project Marian McDonagh, PharmD, Principal Investigator Oregon Evidence-based Practice Center Mark Helfand, MD, MPH, Director Oregon Health & Science University Copyright © 2009 by Oregon Health & Science University Portland, Oregon 97239. All rights reserved. Final Report Update 4 Drug Effectiveness Review Project TABLE OF CONTENTS INTRODUCTION .......................................................................................................................... 6 Purpose and Limitations of Evidence Reports........................................................................................ 8 Scope and Key Questions .................................................................................................................... 10 METHODS.................................................................................................................................
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ZHONG-THESIS-2016.Pdf
ANTIDEPRESSANTMINING AZ AMAZ DESIGNING A WEBBASED ALGORITHM AND VISUAL LANGUAGE FOR ANTIDEPRESSANT DRUG SELECTION TO EDUCATE PRIMARY CARE PRACTITIONERS By Amy Zhong A thesis submitted to Johns Hopkins University in conformity with the requirements for the degree of Master of Arts Baltimore, Maryland March, 2016 © 2016 Amy Zhong All Rights Reserved ABSTRACT Depression is a common mental disorder that affects approximately 14.8 million American adults each year. In addition to being a debilitating condition, depression often occurs in tandem with other medical conditions such as diabetes, heart disease, and cancer. While psychiatric professionals are essential for the management of mental health, majority of patients seek care from their primary care practitioners. This phenomenon is of great concern because diagnosis of depression within primary care settings has only been accurate 25-50% of the time. The antidepressant drug selection algorithm utilizes a unique formula to integrate patient and family medical histories, patient symptoms, and patient preferences to make optimal treatment selections. The development of a visual language explores the use of graphic elements to improve understanding of major pharmacological mechanisms, knowledge essential to making rational DQWLGHSUHVVDQWGUXJVHOHFWLRQV,QFUHDWLQJWKLVPRELOHZHEEDVHGDSSOLFDWLRQZHKRSHWR¿OOD void in resources available to primary care practitioners, and improve management of mental health within the primary care setting. By Amy Zhong Chairpersons of the Supervisory Committee Adam I. Kaplin, M.D., Ph.D., esis Preceptor Assistant Professor, Departments of Psychiatry and Neurology e Johns Hopkins University School of Medicine Kristen Rahn Hollinger, Ph.D., esis Preceptor Instructor, Departments of Psychiatry and Neurology e Johns Hopkins University School of Medicine Jennifer E.
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Folic Acid Antagonists: Antimicrobial and Immunomodulating Mechanisms and Applications
International Journal of Molecular Sciences Review Folic Acid Antagonists: Antimicrobial and Immunomodulating Mechanisms and Applications Daniel Fernández-Villa 1, Maria Rosa Aguilar 1,2 and Luis Rojo 1,2,* 1 Instituto de Ciencia y Tecnología de Polímeros, Consejo Superior de Investigaciones Científicas, CSIC, 28006 Madrid, Spain; [email protected] (D.F.-V.); [email protected] (M.R.A.) 2 Consorcio Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina, 28029 Madrid, Spain * Correspondence: [email protected]; Tel.: +34-915-622-900 Received: 18 September 2019; Accepted: 7 October 2019; Published: 9 October 2019 Abstract: Bacterial, protozoan and other microbial infections share an accelerated metabolic rate. In order to ensure a proper functioning of cell replication and proteins and nucleic acids synthesis processes, folate metabolism rate is also increased in these cases. For this reason, folic acid antagonists have been used since their discovery to treat different kinds of microbial infections, taking advantage of this metabolic difference when compared with human cells. However, resistances to these compounds have emerged since then and only combined therapies are currently used in clinic. In addition, some of these compounds have been found to have an immunomodulatory behavior that allows clinicians using them as anti-inflammatory or immunosuppressive drugs. Therefore, the aim of this review is to provide an updated state-of-the-art on the use of antifolates as antibacterial and immunomodulating agents in the clinical setting, as well as to present their action mechanisms and currently investigated biomedical applications. Keywords: folic acid antagonists; antifolates; antibiotics; antibacterials; immunomodulation; sulfonamides; antimalarial 1.
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Strategies for Managing Sexual Dysfunction Induced by Antidepressant Medication
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M2021: Pharmacogenetic Testing
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Schizophrenia Care Guide
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CDPHP Medicare Advantage 2021 Part D Prior Authorization Criteria
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The Effects of Valbenazine in Participants with Tardive Dyskinesia
SAFETY PROFILE In the extension period, valbenazine was generally well tolerated in a population of LONG-TERM TREATMENT WITH patients with diagnosed schizophrenia, schizoaffective disorder, or mood disorder.8 ONCE-DAILY VALBENAZINE MAY BE AN EFFECTIVE TREATMENT Treatment-emergent adverse events ≥5% in either valbenazine treatment group8,j FOR TD IN ADULTS WITH A • Headache (7.1%) • Dizziness (5.6%) • Urinary tract infection (6.6%) • Suicidal ideation (5.1%) RANGE OF PRESENTATIONS AND • Diarrhea (5.6%) • Depression (4.0%) TREATMENT HISTORIES8 j Combined valbenazine 40 mg and 80 mg once daily.8 • Valbenazine was generally well tolerated through 48 weeks, with There were no clinically important changes in clinical laboratory assessments, sustained TD reductions vital signs, or ECG parameters during the extension or washout periods.8 • TD symptoms tended to return to Psychiatric status generally remained stable during the extension study.8 baseline during the washout period, supporting the maintenance efficacy of ongoing valbenazine treatment LONG-TERM RESULTS AIMS mean score showed sustained TD reduction AIMS score reduction by ≥50% was generally through Week 488,9 consistent through Week 488 Extension study of valbenazine 40 mg and Percentage of extension study participants valbenazine 80 mg (ITT population)10 with AIMS responsel 1.0 100 90 0.0 -0.1 80 -1.0 -1.3 -1.1 -1.4 70 -1.8 -2.0 -2.3 60 -2.2 -2.9 52.4% -2.5 48.0% -3.0 -2.5 50 46.0% -3.0 P<0.001m -3.5 -3.5 40.0% 41.2% 40 -4.0 -4.2 m 28.8% 28.3% -4.2 -4.8 30 P<0.05 -4.3 -4.4 23.8% 23.4%
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Effectiveness of Olanzapine for the Treatment of Breakthrough
Effectiveness of Olanzapine for the Treatment of Breakthrough Chemotherapy Induced Nausea and Vomiting Suthan Chanthawong BPharm*, Suphat Subongkot PharmD*, Aumkhae Sookprasert MD** * Division of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, Thailand ** Department of Internal Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand Objective: To evaluate safety and efﬁcacy of olanzapine for breakthrough emesis in addition to standard antiemetic regimen in cancer patients receiving highly emetogenic chemotherapy. Material and Method: A phase II prospective open label clinical trial was conducted in tertiary care based hospital. Forty-six cancer patients diagnosed with solid tumors were enrolled to receive at least one cycle of highly emetogenic chemotherapy (HEC) every two to four weeks. Each patient was provided standard antiemetic consisting of the generic form of ondansetron plus corticosteroids and metoclopramide according to clinical practice guideline. Olanzapine was administered as 5 mg orally every 12 hours for two doses in patients experiencing breakthrough emesis for at least one episode despite standard prevention. The efﬁcacy and tolerability were evaluated every six hours for 24 hours (utilizing Index of Nausea, Vomiting and Retching: INVR tool). Results: Of 46 evaluable patients receiving HEC and additional olanzapine between September 2009 and July 2010, the complete response of breakthrough emesis, retching, and nausea control among patients were 60.9%, 71.7%, and 50.0%, respectively. Adverse events reported were mild and tolerable including dizziness, fatigue, and dyspepsia. Conclusion: Olanzapine is considered to be safe and effective treatment of breakthrough vomiting in cancer patients undergoing highly emetogenic chemotherapy in the present study. Keywords: Olanzapine, Chemotherapy induced nausea and vomiting, Breakthrough vomiting, Ondansetron, Metoclopramide, Dexamethasone J Med Assoc Thai 2014; 97 (3): 349-55 Full text.
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