US 2004O142914A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2004/0142914 A1 Friedman et al. (43) Pub. Date: Jul. 22, 2004

(54) EXTENDED TRANSDERMAL (60) Provisional application No. 60/363,167, filed on Mar. CONTRACEPTIVE REGIMENS 11, 2002. Provisional application No. 60/381.585, filed on May 17, 2002. (76) Inventors: Andrew Joseph Friedman, Princeton, NJ (US); Katherine D. LaGuardia, Publication Classification New York, NY (US) (51) Int. Cl...... A61K 31/56 (52) U.S. Cl...... 514/170; 424/449 Correspondence Address: PHILIP S. JOHNSON (57) ABSTRACT JOHNSON & JOHNSON A method of contraception is described comprising the Step ONE JOHNSON & JOHNSON PLAZA of administering to a menstruating female a cycle of con NEW BRUNSWICK, NJ 08933-7003 (US) traceptive therapy, Said cycle of therapy including, for at least 42 Successive days, the administration of a combina (21) Appl. No.: 10/626,434 tion of an estrogen and a progestogen in a contraceptively effective daily dosage wherein Said progestogen is a potent (22) Filed: Jul. 24, 2003 Sulfatase inhibiting progestogen and Said cycle of therapy including 4-8 days which are free of estrogen administration Related U.S. Application Data following Said at least 42 Successive days. A method of contraception is also described which provides enhanced (63) Continuation-in-part of application No. 10/385,597, bleeding control and enhanced continuation and Satisfaction filed on Mar. 11, 2003. rates in menstruating females using the method. Patent Application Publication Jul. 22, 2004 Sheet 1 of 4 US 2004/0142914 A1

ESTRONE SULFATE ESTRADIOL SULFOTRANSFERASE ESTRADIOL 17(3-HSD SULFATE SULFATASE ESTRONE

-1.SULFOTRANSFERASE SULFATE AROMATASE ESTRONE

ANDROGENS FIG. 1 Patent Application Publication Jul. 22, 2004 Sheet 2 of 4 US 2004/0142914 A1

86

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