bioRxiv preprint doi: https://doi.org/10.1101/2020.08.24.263624; this version posted August 24, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. 1 TOLLIP promotes durable alveolar macrophage-mediated immunity during Mycobacterium 2 tuberculosis infection by resolving cellular stress from lipids. 3 4 Sambasivan Venkatasubramanian1, Courtney Plumlee2, Kim Dill-McFarland1, Gemma L. 5 Pearson3, Sara B. Cohen2, Anne Lietzke3, Amanda Pacheco3, Robyn Pryor1, Scott A. 6 Soleimanpour3,4, Matthew Altman1, Kevin B. Urdahl2,5, Javeed A. Shah1,6*. 7 1 Department of Medicine, University of Washington, Seattle, WA. 8 2 Seattle Children’s Research Institute, Seattle, WA. 9 3 Department of Internal Medicine, University of Michigan, Ann Arbor, MI. 10 4 VA Ann Arbor Healthcare System, Ann Arbor, MI. 11 5 Departments of Pediatrics and Immunology, University of Washington, Seattle, WA. 12 6 VA Puget Sound Healthcare System, Seattle, WA. * Correspondence:
[email protected]; @ShahLab. 1 bioRxiv preprint doi: https://doi.org/10.1101/2020.08.24.263624; this version posted August 24, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. 13 Summary 14 TOLLIP, a ubiquitin binding protein that controls multiple macrophage functions via 15 endoplasmic reticulum transport and autophagy, is associated with human tuberculosis (TB) 16 susceptibility and immune responses in genetic studies.