Table S10. Hematological analysis of mouse blood samples.

Blood sample were treated with EDTA-K2 as an anticoagulant. The hematological analysis was performed using an Auto Hematology Analyzer BC-5390 CRP (Mindray) with the closure-whole-peripheral-blood mode. Control Soil SS MW Between groups M1 M2 M3 M4 M5 mean ± SEM M1 M2 M3 M4 M5 mean ± SEM M1 M2 M3 M4 M5 mean ± SEM M1 M2 M3 M4 M5 mean ± SEM P-value 9 WBC(10 /L) 7.46 7.85 8.17 9.04 5.61 7.63 ± 0.57 8.21 7.25 9.10 6.71 7.96 7.85 ± 0.41 5.99 9.23 6.19 8.75 7.36 7.50 ± 0.65 8.91 6.11 9.14 6.44 9.47 8.01 ± 0.72 0.93 RBC (1012/L) 9.10 8.99 8.94 8.60 8.96 8.92 ± 0.08 9.30 8.56 8.89 9.00 8.98 8.95 ± 0.12 9.00 8.84 8.89 8.71 9.21 8.93 ± 0.08 8.69 9.11 8.88 8.93 9.01 8.92 ± 0.07 1.00 HGB(g/L) 139.31 135.91 136.19 133.00 134.12 135.71 ± 1.07 139.66 133.67 135.11 136.22 135.10 135.95 ± 1.01 135.52 134.77 135.64 134.33 138.41 135.73 ± 0.71 135.71 132.47 138.11 132.14 139.34 135.55 ± 1.45 1.00 PLT(109/L) 921.23 887.55 770.00 996.12 924.29 899.84 ± 36.97 966.31 810.00 892.47 948.00 910.21 905.40 ± 27.22 1006.12 796.00 914.11 856.32 947.14 903.94 ± 36.28 841.23 997.02 914.32 801.03 936.00 897.92 ± 34.74 1.00 NE% 13.10 19.70 14.20 13.40 12.90 14.66 ± 1.28 14.49 15.03 15.49 13.11 16.21 14.87 ± 0.52 17.53 15.49 15.51 17.37 11.55 15.49 ± 1.08 15.26 14.24 10.50 16.46 16.47 14.59 ± 1.10 0.92 LY% 83.10 79.70 83.40 86.00 86.50 83.74 ± 1.22 72.58 71.26 86.16 64.33 72.61 73.39 ± 3.54 52.78 85.75 57.59 82.66 69.82 69.72 ± 6.55 85.62 56.86 91.44 57.56 88.79 76.05 ± 7.75 0.34 MO% 0.00 0.10 0.00 0.00 0.00 0.02 ± 0.02 0.00 0.01 0.01 0.00 0.00 0.00 ± 0.00 0.00 0.01 0.00 0.01 0.01 0.01 ± 0.00 0.00 0.01 0.01 0.00 0.00 0.00 ± 0.00 0.64 EO% 3.50 0.50 2.40 0.40 0.60 1.48 ± 0.63 0.03 0.01 0.00 0.00 0.02 0.01 ± 0.01 0.02 0.03 0.01 0.00 0.01 0.01 ± 0.01 0.01 0.00 0.00 0.03 0.00 0.01 ± 0.01 0.01 BA% 0.10 0.00 0.00 0.20 0.00 0.06 ± 0.04 0.00 0.00 0.06 0.00 0.00 0.01 ± 0.01 0.00 0.00 0.06 0.00 0.00 0.01 ± 0.01 0.00 0.07 0.10 0.00 0.00 0.03 ± 0.02 0.47 NE(109/L) 0.99 1.55 1.16 1.20 0.72 1.12 ± 0.14 1.19 1.09 1.41 0.88 1.29 1.17 ± 0.09 1.05 1.43 0.96 1.52 0.85 1.16 ± 0.13 1.36 0.87 0.96 1.06 1.56 1.16 ± 0.13 0.99 LY(109/L) 6.20 6.25 6.81 7.78 4.85 6.38 ± 0.48 6.75 6.10 7.66 5.79 6.52 6.56 ± 0.32 4.75 7.58 5.12 7.20 6.43 6.22 ± 0.56 7.44 5.18 8.12 5.14 8.00 6.78 ± 0.67 0.89 MO(109/L) 0.00 0.01 0.00 0.00 0.00 0.00 ± 0.00 0.00 0.01 0.01 0.00 0.00 0.00 ± 0.00 0.00 0.01 0.00 0.01 0.01 0.01 ± 0.00 0.00 0.01 0.02 0.00 0.00 0.01 ± 0.00 0.72 EO(109/L) 0.26 0.04 0.20 0.04 0.03 0.11 ± 0.05 0.27 0.05 0.01 0.04 0.15 0.10 ± 0.05 0.19 0.21 0.10 0.02 0.07 0.12 ± 0.04 0.11 0.04 0.03 0.24 0.01 0.09 ± 0.04 0.96 BA(109/L) 0.01 0.00 0.00 0.01 0.00 0.00 ± 0.00 0.00 0.00 0.01 0.00 0.00 0.00 ± 0.00 0.00 0.00 0.01 0.00 0.00 0.00 ± 0.00 0.00 0.01 0.01 0.00 0.00 0.00 ± 0.00 0.85 MCV(fL) 49.70 50.40 48.40 49.50 48.30 49.26 ± 0.40 48.88 49.95 49.62 48.59 48.01 49.01 ± 0.35 49.51 51.03 49.48 49.13 49.22 49.67 ± 0.35 51.05 47.65 52.05 47.56 51.00 49.86 ± 0.94 0.71 HCT(%) 45.28 45.26 43.31 42.56 43.25 43.93 ± 0.56 45.46 42.76 44.11 43.73 43.11 43.83 ± 0.47 44.56 45.11 43.99 42.79 45.33 44.36 ± 0.46 44.36 43.41 46.22 42.47 45.95 44.48 ± 0.72 0.81 MCH(pg) 15.30 15.20 15.30 15.50 14.90 15.24 ± 0.10 15.02 15.62 15.20 15.14 15.04 15.20 ± 0.11 15.06 15.25 15.26 15.42 15.03 15.20 ± 0.07 15.62 14.54 15.55 14.80 15.47 15.20 ± 0.22 1.00 MCHC(g/L) 307.00 301.00 316.00 313.00 309.00 309.20 ± 2.58 307.22 312.61 306.30 311.50 313.38 310.20 ± 1.44 304.13 298.76 308.34 313.93 305.34 306.10 ± 2.50 305.93 305.16 298.81 311.14 303.24 304.86 ± 2.00 0.30 RDW-CV(%) 13.80 14.00 13.90 13.20 13.90 13.76 ± 0.14 13.50 13.90 14.00 13.50 13.40 13.66 ± 0.12 13.70 13.90 14.10 13.50 13.10 13.66 ± 0.17 13.20 13.90 13.50 14.00 13.60 13.64 ± 0.14 0.94

RDW-SD(fL) 25.30 26.10 24.90 24.30 24.80 25.08 ± 0.30 24.50 25.30 26.10 24.10 24.90 24.98 ± 0.34 24.80 25.70 24.60 26.00 24.90 25.20 ± 0.27 25.10 24.30 25.90 24.90 24.60 24.96 ± 0.27 0.94 MPV(fL) 6.00 6.00 6.00 6.00 5.00 5.80 ± 0.20 6.00 6.00 5.00 5.00 6.00 5.60 ± 0.24 5.00 6.00 6.00 5.00 6.00 5.60 ± 0.24 6.00 6.00 6.00 6.00 6.00 6.00 ± 0.00 0.46 PCT(%) 0.50 0.51 0.45 0.60 0.46 0.50 ± 0.03 0.55 0.47 0.44 0.47 0.55 0.50 ± 0.02 0.50 0.47 0.54 0.43 0.56 0.50 ± 0.02 0.49 0.56 0.51 0.47 0.53 0.51 ± 0.02 0.96 PDW(fL) 14.60 14.50 14.50 14.50 14.40 14.50 ± 0.03 14.20 14.50 14.60 14.30 14.50 14.42 ± 0.07 14.50 14.60 14.50 14.30 14.50 14.48 ± 0.05 14.40 14.60 14.50 14.30 14.60 14.48 ± 0.06 0.76 P-LCR(%) 2.50 2.40 3.00 3.40 2.70 2.80 ± 0.18 2.90 2.30 2.70 3.00 2.90 2.76 ± 0.12 2.90 3.10 2.50 3.20 2.80 2.90 ± 0.12 3.10 2.60 3.10 3.20 2.90 2.98 ± 0.11 0.67 Table S11. Correlation analysis between serum IgE levels and species from shotgun sequencing of gut metagenomics. Spearman correlation and Pearson correlation between serum IgE levels and species were performed using SAS6.4 software. To reduce the Pearson correlation Spearman correlation ID number species coefficient P-value significance coefficient P-value significance 5872 -0.640302 0.002357 0 -0.893890 0.000000 1 Fritillary virus Y 2943 -0.672095 0.001171 0 -0.874765 0.000000 1 Burkholderia glumae 2957 -0.707809 0.000481 0 -0.839098 0.000004 1 Cupriavidus nantongensis 3169 -0.722549 0.000320 0 -0.837157 0.000004 1 Methylophilus sp. TWE2 4088 -0.575772 0.007893 0 -0.836282 0.000004 1 Thermoproteus uzoniensis 955 -0.645765 0.002101 0 -0.830700 0.000006 1 Pseudonocardia sp. AL041005-10 916 -0.695861 0.000656 0 -0.821053 0.000009 0 Brachybacterium sp. VM2412 4532 -0.611050 0.004207 0 -0.820741 0.000009 0 Pseudoalteromonas phage Pq0 1176 -0.705148 0.000516 0 -0.819549 0.000010 0 Sphaerospermopsis kisseleviana 4067 -0.672954 0.001148 0 -0.819105 0.000010 0 Sulfolobus sp. A20 2366 -0.618193 0.003671 0 -0.815038 0.000012 0 Haemophilus influenzae 4435 -0.634542 0.002654 0 -0.809937 0.000015 0 Cellulophaga phage phi19:1 3103 -0.575714 0.007901 0 -0.807519 0.000017 0 Herminiimonas arsenitoxidans 2430 -0.737226 0.000208 0 -0.807070 0.000017 0 Candidatus Baumannia cicadellinicola 892 -0.712663 0.000422 0 -0.806318 0.000018 0 Arthrobacter sp. Rue61a 2084 -0.638400 0.002452 0 -0.806015 0.000018 0 Stenotrophomonas sp. ZAC14D2_NAIMI4_7 3299 -0.635238 0.002616 0 -0.805869 0.000018 0 Campylobacter sp. RM8964 1212 -0.695690 0.000659 0 -0.804511 0.000019 0 Halothece sp. PCC 7418 2690 -0.689304 0.000774 0 -0.801805 0.000021 0 Altererythrobacter namhicola 3162 -0.706121 0.000503 0 -0.797292 0.000026 0 Methylotenera mobilis 3909 -0.750948 0.000136 0 -0.796992 0.000026 0 Methanobacterium subterraneum 2840 -0.658890 0.001581 0 -0.796540 0.000026 0 Candidatus Pelagibacter sp. RS40 2502 -0.694771 0.000675 0 -0.795788 0.000027 0 Bradyrhizobium lablabi 2305 -0.733286 0.000234 0 -0.794284 0.000029 0 Vibrio gazogenes 3523 -0.688596 0.000788 0 -0.792779 0.000031 0 Sulfurihydrogenibium azorense 2055 -0.544720 0.013011 0 -0.790523 0.000034 0 Psychrobacter sp. P2G3 1000 -0.576173 0.007840 0 -0.789771 0.000035 0 Friedmanniella luteola 1862 -0.720050 0.000344 0 -0.789474 0.000035 0 Dickeya sp. Secpp 1600 793 -0.688158 0.000796 0 -0.789018 0.000036 0 Rhodococcus ruber 3268 -0.560659 0.010126 0 -0.787970 0.000037 0 Desulfomonile tiedjei 1093 -0.693607 0.000695 0 -0.786762 0.000039 0 Jatrophihabitans sp. GAS493 119 -0.660276 0.001533 0 -0.786010 0.000040 0 Thermoanaerobacterium xylanolyticum 3515 -0.579472 0.007413 0 -0.785096 0.000041 0 Thermocrinis albus 767 -0.595812 0.005569 0 -0.784506 0.000042 0 Mycolicibacterium thermoresistibile 2679 -0.718200 0.000362 0 -0.783459 0.000044 0 Zymomonas mobilis 2514 -0.609795 0.004308 0 -0.783001 0.000045 0 Bosea sp. RAC05 2807 -0.640251 0.002359 0 -0.782249 0.000046 0 Acetobacter tropicalis 2437 -0.658146 0.001607 0 -0.780286 0.000049 0 Candidatus Ruthia magnifica 965 -0.663927 0.001412 0 -0.778947 0.000052 0 Actinosynnema pretiosum 2051 -0.617475 0.003722 0 -0.777569 0.000055 0 Psychrobacter arcticus 1933 -0.571154 0.008528 0 -0.777444 0.000055 0 Pseudomonas taetrolens 2387 -0.558811 0.010431 0 -0.772932 0.000065 0 Glaesserella parasuis 3145 -0.473878 0.034795 0 -0.768710 0.000075 0 Aquaspirillum sp. LM1 1098 -0.593344 0.005820 0 -0.768421 0.000076 0 Modestobacter marinus 2072 -0.637102 0.002518 0 -0.768421 0.000076 0 Xanthomonas fragariae 2553 -0.644491 0.002159 0 -0.767958 0.000077 0 Aminobacter aminovorans 2365 -0.656756 0.001657 0 -0.767206 0.000079 0 Thioploca ingrica 4318 -0.604294 0.004772 0 -0.765061 0.000085 0 Campylobacter virus CPX 3395 -0.644398 0.002163 0 -0.763910 0.000088 0 Parachlamydia acanthamoebae 3425 -0.609746 0.004312 0 -0.763732 0.000089 0 Borrelia duttonii 603 -0.462703 0.039945 0 -0.763445 0.000090 0 Streptomyces ambofaciens 3580 -0.704780 0.000521 0 -0.759398 0.000103 0 Thermothelomyces thermophila 862 -0.654485 0.001742 0 -0.758180 0.000107 0 Agrococcus carbonis 344 -0.757568 0.000110 0 -0.756391 0.000114 0 Planococcus plakortidis 2348 -0.699080 0.000604 0 -0.753667 0.000124 0 Francisella sp. TX077308 2794 -0.672179 0.001168 0 -0.753667 0.000124 0 Haematospirillum jordaniae 2123 -0.637180 0.002514 0 -0.753383 0.000126 0 Marinobacter adhaerens 3164 -0.573918 0.008143 0 -0.752915 0.000128 0 Candidatus Methylopumilus planktonicus 2052 -0.525989 0.017212 0 -0.752446 0.000129 0 Psychrobacter sp. G 3170 -0.685388 0.000852 0 -0.751880 0.000132 0 Nitrosomonas communis 1358 -0.672532 0.001159 0 -0.750658 0.000137 0 Deinococcus deserti 4024 -0.532674 0.015604 0 -0.750376 0.000138 0 Thermococcus cleftensis 1751 0.732856 0.000237 0 0.796992 0.000026 0 Cronobacter malonaticus 2303 0.685132 0.000858 0 0.773975 0.000062 0 Vibrio tasmaniensis 3649 0.603432 0.004849 0 0.760902 0.000098 0 Coccidioides posadasii 1916 0.561986 0.009912 0 0.754419 0.000121 0 Pseudomonas veronii Table S12. Correlation analysis between serum IgE levels and Kyoto Encyclopedia of Genes and Genomes (KEGG) entries based on shotgun sequencing of gut metagenomics. Spearman correlation and Pearson correlation between serum IgE level and KEGG entry were performed uing SAS6.4 software. To reduce the probability of type I error in the multiple comparisons, the Bonferroni method was used to adjust the level of significance. Pearson correlation Spearman correlation Kegg entry Kegg entry description coefficient P-value significance coefficient P-value significance K03226 -0.725725 0.000292 0 -0.950376 0.000000 1 yscR, sctR, hrcR; type III secretion protein R K09882 -0.662564 0.001456 0 -0.945865 0.000000 1 cobS; cobaltochelatase CobS [EC:6.6.1.2] K03230 -0.652120 0.001834 0 -0.944361 0.000000 1 yscV, sctV, hrcV; type III secretion protein V K03224 -0.647439 0.002028 0 -0.927820 0.000000 1 yscN, sctN, hrcN; ATP synthase in type III secretion protein N [EC:3.6.3.14] K01556 -0.683219 0.000899 0 -0.923308 0.000000 1 KYNU, kynU; kynureninase [EC:3.7.1.3] K03223 -0.664625 0.001390 0 -0.906767 0.000000 1 yscL, sctL; type III secretion protein L K03229 -0.642089 0.002271 0 -0.906767 0.000000 1 yscU, sctU, hrcU; type III secretion protein U K07236 -0.671953 0.001175 0 -0.882707 0.000000 1 tusC, dsrF; tRNA 2-thiouridine synthesizing protein C K03544 -0.728307 0.000271 0 -0.861654 0.000001 1 clpX, CLPX; ATP-dependent Clp protease ATP-binding subunit ClpX K03227 -0.677851 0.001022 0 -0.860150 0.000001 1 yscS, sctS, hrcS; type III secretion protein S K00231 -0.721094 0.000334 0 -0.854135 0.000002 1 PPOX, hemY; oxygen-dependent protoporphyrinogen oxidase [EC:1.3.3.4] K03588 -0.649785 0.001929 0 -0.837594 0.000004 1 ftsW, spoVE; cell division protein FtsW K01251 -0.685346 0.000853 0 -0.836090 0.000004 1 E3.3.1.1, ahcY; adenosylhomocysteinase [EC:3.3.1.1] K01358 -0.648930 0.001964 0 -0.818045 0.000011 1 clpP, CLPP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92] K11646 -0.618174 0.003672 0 -0.810526 0.000015 1 K11646; 3-dehydroquinate synthase II [EC:1.4.1.24] K18138 -0.611494 0.004172 0 -0.809023 0.000016 1 acrB, mexB, adeJ, smeE, mtrD, cmeB; multidrug efflux pump K11752 -0.670189 0.001224 0 -0.804511 0.000019 1 ribD; diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase [EC:3.5.4.26 1.1.1.193] K03575 -0.587093 0.006499 0 -0.792481 0.000031 0 mutY; A/G-specific adenine glycosylase [EC:3.2.2.-] K12257 -0.640164 0.002364 0 -0.786466 0.000039 0 secDF; SecD/SecF fusion protein K01338 -0.579103 0.007460 0 -0.783459 0.000044 0 lon; ATP-dependent Lon protease [EC:3.4.21.53] K03589 -0.619248 0.003597 0 -0.783459 0.000044 0 ftsQ; cell division protein FtsQ K00680 -0.654061 0.001758 0 -0.781955 0.000046 0 E2.3.1.-; [EC:2.3.1.-] K01816 -0.582277 0.007065 0 -0.781955 0.000046 0 hyi, gip; hydroxypyruvate isomerase [EC:5.3.1.22] K00943 -0.701763 0.000564 0 -0.777444 0.000055 0 tmk, DTYMK; dTMP kinase [EC:2.7.4.9] K02316 -0.645717 0.002104 0 -0.774436 0.000061 0 dnaG; DNA primase [EC:2.7.7.-] K07456 -0.683789 0.000886 0 -0.774436 0.000061 0 mutS2; DNA mismatch repair protein MutS2 K04751 -0.667239 0.001310 0 -0.766917 0.000080 0 glnB; nitrogen regulatory protein P-II 1 K00800 -0.604298 0.004772 0 -0.765414 0.000084 0 aroA; 3-phosphoshikimate 1-carboxyvinyltransferase [EC:2.5.1.19] K03601 -0.672932 0.001148 0 -0.762406 0.000093 0 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6] K11903 -0.628212 0.003015 0 -0.759398 0.000103 0 K11903, hcp; type VI secretion system secreted protein Hcp K01791 -0.693717 0.000693 0 -0.753383 0.000126 0 wecB; UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing) [EC:5.1.3.14] K07650 0.756368 0.000114 0 0.818045 0.000011 1 cssS; two-component system, OmpR family, sensor histidine kinase CssS [EC:2.7.13.3] K11996 0.568205 0.008955 0 0.751880 0.000132 0 MOCS3, UBA4, moeB; adenylyltransferase and sulfurtransferase [EC:2.7.7.80] Table S13. Comparison of the abundance of structure protein genes of the bacterial secretion system.

This table lists all the bacterial secretion system protein genes recorded in the Kyoto Encyclopedia of Genes and Genomes (KEGG) database and the genes identified from shotgun sequencing of the gut microbial metagenome in the current research. Comparisons were carried on the abundance of genes for the bacterial secretion system between each two group mice and the significantly different genes are listed in red.

Is it significant differences? Structure protein of Bacterial secretion system in KEGG Kegg entry Was it sequenced? bank Soil vs Con SS vs Con MW vs Con Soil vs MW SS vs MW Soil vs SS K12340 outer membrane protein YES YES K12257 SecD/SecF fusion protein YES YES YES YES YES K11912 serine/threonine-protein kinase PpkA [EC:2.7.11.1] YES K11906 type VI secretion system protein VasD YES YES YES K11904 type VI secretion system secreted protein VgrG YES K11903 type VI secretion system secreted protein Hcp YES K11892 type VI secretion system protein ImpK YES YES YES K11891 type VI secretion system protein ImpL YES YES YES K11004 ATP-binding cassette, subfamily B, bacterial HlyB/CyaB YES YES YES YES YES K03230 type III secretion protein V YES YES YES YES YES YES K03229 type III secretion protein U YES YES YES YES YES K03227 type III secretion protein S YES YES YES YES YES K03226 type III secretion protein R YES YES YES YES YES YES K03224 ATP synthase in type III secretion protein N [EC:7.4.2.8] YES YES YES YES YES YES K03223 type III secretion protein L YES YES YES YES YES YES K03222 type III secretion protein J YES K03217 YidC/Oxa1 family membrane protein insertase YES K03210 preprotein translocase subunit YajC YES YES K03205 type IV secretion system protein VirD4 [EC:7.4.2.8] YES YES K03204 type IV secretion system protein VirB9 YES K03203 type IV secretion system protein VirB8 YES YES K03201 type IV secretion system protein VirB6 YES YES K03199 type4 YES K03197 type IV secretion system protein VirB2 YES K03195 type 4 YES K03195 type IV secretion system protein VirB10 YES K03118 sec-independent protein translocase protein TatC YES YES YES YES K03117 sec-independent protein translocase protein TatB YES K03116 sec-independent protein translocase protein TatA YES YES YES K03106 signal recognition particle subunit SRP54 [EC:3.6.5.4] YES YES K03106 type IV secretion system protein VirB11 [EC:7.4.2.8] YES K03100 type IV secretion system protein VirB4 [EC:7.4.2.8] YES YES YES K03076 preprotein translocase subunit SecY YES K03075 preprotein translocase subunit SecG YES YES YES YES K03074 preprotein translocase subunit SecF YES YES K03073 preprotein translocase subunit SecE YES YES YES YES K03072 preprotein translocase subunit SecD YES K03071 preprotein translocase subunit SecB YES K03070 preprotein translocase subunit SecA [EC:7.4.2.8] YES YES YES YES YES K02456 general secretion pathway protein G YES K02454 general secretion pathway protein E [EC:7.4.2.8] YES K02453 general secretion pathway protein D YES K02110 fused signal recognition particle receptor YES YES YES K13301 secretion monitor NO K12342 adhesin YadB/C NO K12341 adhesin YadA NO K11915 serine/threonine protein phosphatase Stp1 [EC:3.1.3.16] NO K11913 type VI secretion system protein NO K11907 type VI secretion system protein VasG NO K11028 vacuolating cytotoxin NO K11017 hemolysin activation/secretion protein NO K11016 hemolysin NO K11003 hemolysin D NO K04059 type III secretion protein X NO K04058 type III secretion protein W NO K04057 type III secretion protein P NO K04056 type III secretion protein O NO K03425 sec-independent protein translocase protein TatE NO K03228 type III secretion protein T NO K03225 type III secretion protein Q NO K03221 type III secretion protein F NO K03219 type III secretion protein C NO K03202 type IV secretion system protein VirB7 NO K03200 type IV secretion system protein VirB5 NO K03198 type IV secretion system protein VirB3 NO K03194 type IV secretion system protein VirB1 NO K02465 general secretion pathway protein S NO K02464 general secretion pathway protein O [EC:3.4.23.43 2.1.1.-] NO K02462 general secretion pathway protein M NO K02461 general secretion pathway protein L NO K02460 general secretion pathway protein K NO K02459 general secretion pathway protein J NO K02458 general secretion pathway protein I NO K02457 general secretion pathway protein H NO K02455 general secretion pathway protein F NO K02452 general secretion pathway protein C NO