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PROCEEDINGS VETERINARY PATHOLOGY SERVICE WEDNESDAY SLIDE CONFERENCE 2013-2014 JOINT PATHOLOGY CENTER SILVER SPRING, MD 20910 2014 ML2014 JOINT PATHOLOGY CENTER VETERINARY PATHOLOGY SERVICE WEDNESDAY SLIDE CONFERENCE 2013-2014 100 Cases JOINT PATHOLOGY CENTER SILVER SPRING, MD 20910 2013 ML2014 i PREFACE The Veterinary Pathology Service of the Joint Pathology Center (JPC), formerly known as the Armed Forces Institute of Pathology, has conducted a weekly slide conference during the resident training year since 12 November 1953. This ever-changing educational endeavor has evolved into the annual Wednesday Slide Conference program in which cases are presented on 25 Wednesdays throughout the academic year and distributed to 135 contributing military and civilian institutions from around the world. Many of these institutions provide structured veterinary pathology resident training programs. During the course of the training year, histopathology slides, digital images, and histories from selected cases are distributed to the participating institutions and to the JPC Veterinary Pathology Service. Following the conferences, the case diagnoses, comments, and reference listings are posted online to all participants. This study set has been assembled in an effort to make Wednesday Slide Conference materials available to a wider circle of interested pathologists and scientists, and to further the education of veterinary pathologists and residents-in- training. The number of histopathology slides that can be reproduced from smaller lesions requires us to limit the number of participating institutions. For their participation and permission to use their cases in this study set, we wish to thank each institution, and especially the individuals who prepared and submitted the selected cases. A special note of appreciation is extended to the reviewers who helped edit and review this year’s individual case summaries: A final note of thanks goes to the moderators, who unselfishly gave of their time and expertise to help make each conference both enjoyable and educational. Gross images and photomicrographs were submitted by contributing institutions where indicated. Additional photomicrographs were taken by ii Joint Pathology Center WEDNESDAY SLIDE CONFERENCE 2013-2014 Table of Contents Conference 1 11 Sep 2013 Case JPC No. Slide No. Species Etiology/ Condition Tissue Page 1 4032712 12-236 Dog Epidermoid cyst Brain, 4th ventricle 1 2 4031864 10-461 Dog Emphysematous cystitis Urinary bladder 6 3 4032564 55860 Blackbuck Necrotizing enteritis (Etiology: Yersinia pseudotuberculosis) Small intestine 9 4 4032701 DR30 Rhesus Blastomycosis (Etiology: Blastomyces dermatitidis) Kidney macaque 13 Conference 2 18 Sep 2013 1 4033366 C1707 Dog Fungal myocarditis (Etiology: Scedosporium prolificans) Heart 16 2 4033380 NCAH 2013-2 Ox Mycobacteriosis Lung 20 3 4032817 N2012AFIP938 Rock Hyrax Ulcerative pharyngitis (Etiology: Hyrax herpesvirus) Pharynx 25 4 4017829 2105011 Dog Adenocarcinoma Pancreas 28 Conference 3 26 Sep 2013 1 4032910 04135-11 Cynomolgus Suppurative prostatitis (Etiology: Burkholderia Prostate gland 31 macaque pseudomallei) 2 4017832 DX12-72 Short-tailed Vegetative valvular endocarditis Heart 36 possum 3 4032440 PV00129C1 Dog Leishmaniasis (Etiology: Leishmania infantum) Kidney 39 4 4033559 G8745 Ring-tailed Hepatic necrosis (Etiology: Listeria monocytogenes) Liver 43 lemur Conference 4 9 Oct 2012 1 4032962 C13-122 Ferret Chordoma Fine needle aspirate of vertebral mass 47 2 4032703 N12-247 Rat snake Proliferative gastritis (Etiology: Cryptosporidium sp.) Stomach 51 3 4019387 WSC 2012 #1 Rabbit Renal Encephalitizoonosis (Etiology: Encephalitozoon Kidney cuniculi) 54 4 4025191 12-0399 Goat Contagious ecthyma (Etiology: Caprine parapoxvirus) Skin 58 Conference 5 16 Oct 2013 1 4019350 N12-191 Pig Fibrinosuppurative ventriculitis (Etiology: Streptococcus Brain, cerebrum and lateral suis) ventricle 62 2 4032261 D120073 Raccoon Neuronal and histiocytic vacuolation (Sphingomyelinosis/ Brain, cerebellum; spleen Niemann-Pick Disease) 66 3 4032320 11-342 Cat Fibrocartilagenous emboli with infarcts Spinal cord 72 4 4019357 L11-8963 Mouse Carcinoma Prostate gland 76 iii WSC 2013-2014 Table of Contents Case JPC No. Slide No. Species Etiology/ Condition Tissue Page Conference 6 23 Oct 2013 1 4032579 WSC 2013 Case #2 Goat Malignant catarrhal fever (Ovine herpesvirus-2) Kidney 79 2 4004353 10-1729 Dog Intravascular lymphoma Brain, cerebrum and midbrain 84 3 4002867 T11-09742 Cat Feline inductive odontogenic tumor Gingiva 89 4 4035415 11-0193-1/2 Rhesus Amyloidosis Transmission electron macaque microscopic image of liver, 93 space of Disse Conference 7 30 Oct 2013 1 4032698 CSUVTH Sheep Sheep Bronchopneumonia (Etiology: Mycoplasma ovipneumoniae Lung and Mannheimia haemolytica) 97 2 4032481 13-3472 Dog Pseudo-placentational endometrial hyperplasia Uterus, endometrium 102 3 4006298 H11-0101-A Dog Massive hepatocellular necrosis (indospicine toxicity) Liver from two different dogs 106 4 4035422 NIAH 2013 2 Duck Necrotizing folliculitis (Etiology: H5N1 highly pathogenic Skin, feather follicle avian influenza virus) 112 Conference 8 6 Nov 2013 1 4035110 MLP12093 Rat Polycystic kidney disease Kidney; liver 116 2 4032702 KM07/13A342 Rhesus Teratoma Testis macaque 121 3 4036188 MK12-3255 Rhesus Suppurative bronchopneumonia (Etiology: Klebsiella Lung macaque pneumonia) 125 4 4036187 MK12-557 Rhesus Necrotizing dermatitis (Etiology: Macacine herpesvirus-1) Skin, pinna macaque 130 Conference 9 4 Dec 2013 1 4018680 TVMDL 2012-02 Meerkat Cerebellar abiotrophy Brain, cerebellum 135 2 4032319 B10-1823-2L Dog Atherosclerosis Brain, cerebrum 140 3 4035522 NIAH 2013 1 Pig Nonsuppurative meningoencephalitis (Etiology: Japanese Brain, cerebrum encephalitis virus) 146 4 4002855 F1021947 Dog Granulomatous encephalitis (Etiology: dematiaceous fungal Brain, cerebrum species) 150 Conference 10 10 Dec 2013 1 4019833 TP-10-016 Cynomolgus Olfactory neuroblastoma Skull, nasal cavity and macaque paranasal sinus 154 2 4033368 E 1242/12 Chicken Central chromatolysis (Etiology: Avian encephalomyelitis Brainstem virus) 158 3 4034401 UFSM-2 Pig Eosinophilic granulocytic sarcoma Bone marrow, vertebral body 161 4 4007419 H11-164 Ox Bovine neonatal pancytopenia Bone marrow, sternebra 165 iv WSC 2013-2014 Table of Contents Case JPC No. Slide No. Species Etiology/ Condition Tissue Page Conference 11 8 Jan 2014 1 4017804 A12-5214 Cat Granulomatous and eosinophilic enteritis (Etiology: Pythium Small intestine insidiosum) 169 2 4009691 11-37333 Dog Lymphangiectasia Small intestine 172 3 4018123 111156-15 Cat Plasma cell myeloma Bone marrow 175 4 4032561 2013 KSU VDL-2 Dog Degeneration and necrosis (Etiology: Canine morbillivirus/ Tooth, ameloblasts Canine distemper virus) 180 Conference 12 15 Jan 2014 1 4033123 12-1353 Hamster Pyogranulomatous dermatitis (Etiology: Mycobacterium Skin ulcerans and M. marinum) 183 2 4001270 AFIP1 Pfizer Rabbit Colitis (Etiology: enteropathogenic Esherichia coli) Colon 186 3 4032443 13-V212 Mouse αB-crystallin knockout myopathy Tongue, skeletal muscle 191 4 4035410 12-0122-7 Mouse Spontaneous unilateral brainstem infarction in Swiss mice Brainstem 194 Conference 13 29 Jan 2014 1 4032590 AVC C3670-13 Dog Liver; skin Hepatocutaneous syndrome (superficial necrolytic 198 dermatitis) 2 4006293 4378 Dog Peripheral blood smear (cytology) Immune mediated hemolytic anemia 204 3 4032251 17796-12 Alpaca Hypervitaminosis D Kidney 209 4 4006472 33786/2-26 Horse Acute myeloid leukemia Bone marrow; liver 213 Conference 14 5 Feb 2014 1 4032267 120657-05 Cynomolgus Pyogranulomatous pneumonia (Etiology: Coccidioides spp.) Lung macaque 219 2 4007165 SN 11-1511 Cynomolgus Degeneration, necrosis and regeneration (aminoglycoside Kidney, proximal 225 macaque toxicity) convoluted tubules 3 4035680 PO-507/13 Pig Osteochondroma Bone, rib 229 4 4033119 13-6408 Sheep fetus Myocyte hypoplasia (Etiology: Cache valley virus) Skeletal muscle and adipose tissue 232 Conference 15 12 Feb 2014 1 4035545 T2319/13 Cat Feline fibropapilloma (sarcoid) Skin and footpad 236 2 4018119 10058-12 Dog Exfoliative cutaneous lupus erythematosus of the German Skin shorthaired pointer 242 3 4018118 6069-12 Cat Acquired skin fragility syndrome and hepatic lipidosis Skin; liver 246 4 4018075 2011905671 Dog Glomus tumor Skin 251 v WSC 2013-2014 Table of Contents Case JPC No. Slide No. Species Etiology/ Condition Tissue Page Conference 16 19 Feb 2014 1 4001100 11-V62 Mouse Rhabdomyosarcoma Vertebral body and epaxial musculature 254 2 4003041 161 2A Partridge Cerebral tissue pulmonary embolization Lung, pulmonary arteries 259 3 4025665 JPC WSC #2 SD Rat Degeneration and necrosis (1,3-dinitrobenzene toxicity) Testicle, seminiferous tubules 262 4 4035678 A543/405/223-13 Chicken Inclusion body hepatitis (Etiology: Aviadenovirus) Liver 265 Conference 17 26 Feb 2014 1 4033980 48772-A Ram Necrotizing myocarditis (Etiology: C. chauvoei and C. Heart septicum) 269 2 3165179 AFIP-WSC H8674 39 Rhesus Necrotizing myocarditis (Etiology: Trypanosoma cruzi) Heart macaque 273 3 4034294 12-17590 Ox Suppurative and necrotizing pyelonephritis (Etiology: Kidney Corynebacterium renale) 277 4 4032715 0386/10 Goat Lymphohistiocytic interstitial pneumonia (Etiology: caprine Lung arthritis encephalitis virus) 282 Conference 18 12 Mar 2014 1 4032911 N13-46 Horse Equine multinodular pulmonary fibrosis (Etiology: Equine Lung herpesvirus-5) 286 2 4035597 KAHDL 8398 Horse Neuronal degeneration (Etiology: rabies virus) Spinal cord, gray matter 290 3
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    supplement to qualitative interpretation of scintiscans, pulmo 13. Hirose Y, lmaeda T, Doi H, Kokubo M, Sakai 5, Hirose H. Lung perfusion SPECT in nary perfusion scintigraphy will become a more useful tech predicting postoperative pulmonary function in lung cancer. Ann Nuc/ Med 1993:7: 123—126. nique for clinical evaluation of treatment and assessment of 14. Hosokawa N, Tanabe M, Satoh K. et al. Prediction of postoperative pulmonary breathlessness and respiratory failure than the usual one. function using 99mTcMAA perfusion lung SPECT. Nippon Ada Radio/ 1995;55:414— 422. 15. Richards-Catty C, Mishkin FS. Hepatic activity on perfusion lung images. Semi,, Nuci REFERENCES Med l987;l7:85—86. I. Wagner UN Jr. Sabiston DC ir, McAee JG, Tow D, Stem HS. Diagnosis of massive 16. Kitani K, Taplin GV. Biliary excretion of9@―Tc-albuminmicroaggregate degradation pulmonaryembolism in man by radioisotopescanning.N Engli Med 1964;27l:377-384. products (a method for measuring Kupifer cell digestive function?). J Naic! Med 2. Maynard CD. Cowan Ri. Role of the scan in bronchogenic carcinoma. Semin Nuci 1972:13:260—265. Med 1971;l:195—205. 17. Marcus CS, Parker LS, Rose 1G. Cullison RC. Grady P1. Uptake of ‘@“Tc-MAAby 3. Newman GE, Sullivan DC, Gottschalk A, Putman CE. Scintigraphic perfusion pattems the liver during a thromboscintigram/lung scan. J Nuci Med 1983;24:36—38. in patients with diffuse lung disease. Radiology 1982;l43:227—23l. 18. Gates GF, Goris ML. Suitability of radiopharmaceuticals for determining right-to-left 4. Clarke SEM, Seeker-Walker RH. Lung scanning.
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  • A Case of Lupus Vulgaris Carmen D

    A Case of Lupus Vulgaris Carmen D

    Symmetrically Distributed Orange Eruption on the Ears: A Case of Lupus Vulgaris Carmen D. Campanelli, BS, Wilmington, Delaware Anthony F. Santoro, MD, Philadelphia, Pennsylvania Cynthia G. Webster, MD, Hockessin, Delaware Jason B. Lee, MD, New York, New York Although the incidence and morbidity of tuberculo- sis (TB) have declined in the latter half of the last decade in the United States, the number of cases of TB (especially cutaneous TB) among those born outside of the United States has increased. This discrepancy can be explained, in part, by the fact that cutaneous TB can have a long latency period in those individuals with a high degree of immunity against the organism. In this report, we describe an individual from a region where there is a rela- tively high prevalence of tuberculosis who devel- oped lupus vulgaris of the ears many years after arrival to the United States. utaneous tuberculosis (TB) is a rare manifes- tation of Mycobacterium tuberculosis infection. C Scrofuloderma, TB verrucosa cutis, and lupus vulgaris (LV) comprise most of the cases of cutaneous TB. All 3 are rarely encountered in the United States. During the last several years, the incidence of TB has declined in the United States, but the incidence of these 3 types of cutaneous TB has increased in foreign-born individuals. This discrepancy can be ex- plained, in part, by the fact that TB can have a long latency period, especially in those individuals with a Figure 1. Orange plaques and nodules on the right ear. high degree of immunity against the organism. Indi- viduals from regions where there is a high prevalence Case Report of TB may develop cutaneous TB many years after ar- A 71-year-old man from the Philippines presented rival to the United States, despite screening protocol with an eruption on both ears that had existed for when they enter the United States.