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Myopathy Associated with Pigmentary Degene- Ration
MYOPATHY ASSOCIATED WITH PIGMENTARY DEGENE RATION OF THE RETINA AND HIGH PROTEIN CONTENT OF CEREBROSPINAL FLUID JOSÉ ANTONIO LEVY*; MlLBERTO SCAFF*; ANA MARIA C. TSANACLIS**; VANDERLEI GARCIA RODRIGUES**; EDGARD SILVA LUSVARGHI** Harenko and Lapallainen4 (1962) reported a case of chronic progressive ophtalmoplegia with pigmentary degeneration of the retina, also referring 5 similar reports. Assis1 (1967) published the case of a 16-year-old female patient with progressive ophthalmoplegia, which began with palpebral ptosis and pigmentary degeneration of the retina, spreading to the macular regions; biopsy of the left superior rectus muscle showed a dystrophic process, i.e., a myopathy. Olson6 reported 7 cases of progressive ophthalmoplegia (patients' ages varied between 11 and 47 years, the period of time from the onset of the disease varying between 3 and 12 years) in which the biopsy of clinically normal limb muscles showed alterations confirming the existence of a myo pathy. A biopsy revealing myopathy and the external ophtalmoplegia were common in all these patients. Three of them displayed pigmentary retinosis; three had a slight motor deficit in the limb girdle muscles; four had electro- encephalographic abnormalities; in 5 of the cases which underwent a cerebro spinal fluid examination, a high protein content was encountered; in four cases the muscle biopsy showed alterations which suggested a lesion of the peripheral motor nerve; none of the cases suggested progressive muscular dystrophy with serious motor deficit in the limb girdle muscles. Kearn, quoted by Engel2, reported the case of a myopathic patient with external ophtalmo plegia associated with cardiomyopathy and pigmentary degeneration of the retina. -
Te2, Part Iii
TERMINOLOGIA EMBRYOLOGICA Second Edition International Embryological Terminology FIPAT The Federative International Programme for Anatomical Terminology A programme of the International Federation of Associations of Anatomists (IFAA) TE2, PART III Contents Caput V: Organogenesis Chapter 5: Organogenesis (continued) Systema respiratorium Respiratory system Systema urinarium Urinary system Systemata genitalia Genital systems Coeloma Coelom Glandulae endocrinae Endocrine glands Systema cardiovasculare Cardiovascular system Systema lymphoideum Lymphoid system Bibliographic Reference Citation: FIPAT. Terminologia Embryologica. 2nd ed. FIPAT.library.dal.ca. Federative International Programme for Anatomical Terminology, February 2017 Published pending approval by the General Assembly at the next Congress of IFAA (2019) Creative Commons License: The publication of Terminologia Embryologica is under a Creative Commons Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) license The individual terms in this terminology are within the public domain. Statements about terms being part of this international standard terminology should use the above bibliographic reference to cite this terminology. The unaltered PDF files of this terminology may be freely copied and distributed by users. IFAA member societies are authorized to publish translations of this terminology. Authors of other works that might be considered derivative should write to the Chair of FIPAT for permission to publish a derivative work. Caput V: ORGANOGENESIS Chapter 5: ORGANOGENESIS -
Sacrospinous Ligament Suspension and Uterosacral Ligament Suspension in the Treatment of Apical Prolapse
6 Review Article Page 1 of 6 Sacrospinous ligament suspension and uterosacral ligament suspension in the treatment of apical prolapse Toy G. Lee, Bekir Serdar Unlu Division of Urogynecology, Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston, Texas, USA Contributions: (I) Conception and design: All authors; (II) Administrative support: All authors; (III) Provision of study materials or patients: None; (IV) Collection and assembly of data: All authors; (V) Data analysis and interpretation: All authors; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors. Correspondence to: Toy G. Lee, MD. Division of Urogynecology, Department of Obstetrics and Gynecology, The University of Texas Medical Branch, 301 University Blvd, Galveston, Texas 77555, USA. Email: [email protected]. Abstract: In pelvic organ prolapse, anatomical defects may occur in either the anterior, posterior, or apical vaginal compartment. The apex must be evaluated correctly. Often, defects will occur in more the one compartment with apical defects contributing primarily to the descent of the anterior or posterior vaginal wall. If the vaginal apex, defined as either the cervix or vaginal cuff after total hysterectomy, is displaced downward, it is referred to as apical prolapse and must be addressed. Apical prolapse procedures may be performed via native tissue repair or with the use of mesh augmentation. Sacrospinous ligament suspension and uterosacral ligament suspension are common native tissue repairs, traditionally performed vaginally to re-support the apex. The uterosacral ligament suspension may also be performed laparoscopically. We review the pathophysiology, clinical presentation, evaluation, pre-operative considerations, surgical techniques, complications, and outcomes of these procedures. -
Laparoscopic Extraperitoneal Salpingo-Oophorectomy in Women with Suspicious Ovarian Mass, a Way to Reduce the Risk of Spillage
5 Surgical Technique Page 1 of 5 Laparoscopic extraperitoneal salpingo-oophorectomy in women with suspicious ovarian mass, a way to reduce the risk of spillage Giulio Sozzi, Giulia Zaccaria, Mariano Catello Di Donna, Giuseppina Lo Balbo, Stefania Cannarozzo, Vito Chiantera Department of Gynecologic Oncology, University of Palermo, Piazza Nicola Leotta, Palermo, Italy Correspondence to: Giulio Sozzi, MD. Department of Gynecologic Oncology, University of Palermo, Piazza Nicola Leotta 4, 90127 Palermo, Italy. Email: [email protected]. Abstract: The objective of the present paper is to provide a step by step description of the laparoscopic extraperitoneal salpingo-oophorectomy, a surgical technique useful to reduce the risk of spillage in women with suspected ovarian masses. The patient was a 52-year-old woman with sonographic diagnosis of a multilocular, 5 cm lesion, with Color Score 3 at right ovary. Computed tomography (CT) scan excluded any other localization of disease. Tumor markers were negative, except for Ca 19.9 that was 85 IU/mL. Preliminary diagnostic laparoscopy was performed and peritoneal carcinomatosis was excluded. In order to obtain a histological diagnosis, an extraperitoneal right salpingo-oophorectomy was performed. At frozen section analysis it was diagnosed an ovarian adenocarcinoma. Therefore, a laparoscopic complete surgical staging including total hysterectomy, controlateral salpingo-oophorectomy, infracolic omentectomy, multiple peritoneal biopsies, and pelvic and para-aortic lymphadenectomy, was performed. Operative time was 240 minutes and estimated blood loss was about 50 mL. No intra or post-operative complications were observed, and the patient was discharged 3 days after surgery. Final histology showed the presence of clear cell high grade carcinoma in both ovaries without fallopian tubes infiltration. -
Chapter 28 *Lecture Powepoint
Chapter 28 *Lecture PowePoint The Female Reproductive System *See separate FlexArt PowerPoint slides for all figures and tables preinserted into PowerPoint without notes. Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Introduction • The female reproductive system is more complex than the male system because it serves more purposes – Produces and delivers gametes – Provides nutrition and safe harbor for fetal development – Gives birth – Nourishes infant • Female system is more cyclic, and the hormones are secreted in a more complex sequence than the relatively steady secretion in the male 28-2 Sexual Differentiation • The two sexes indistinguishable for first 8 to 10 weeks of development • Female reproductive tract develops from the paramesonephric ducts – Not because of the positive action of any hormone – Because of the absence of testosterone and müllerian-inhibiting factor (MIF) 28-3 Reproductive Anatomy • Expected Learning Outcomes – Describe the structure of the ovary – Trace the female reproductive tract and describe the gross anatomy and histology of each organ – Identify the ligaments that support the female reproductive organs – Describe the blood supply to the female reproductive tract – Identify the external genitalia of the female – Describe the structure of the nonlactating breast 28-4 Sexual Differentiation • Without testosterone: – Causes mesonephric ducts to degenerate – Genital tubercle becomes the glans clitoris – Urogenital folds become the labia minora – Labioscrotal folds -
Comparative Anatomy of the Lower Respiratory Tract of the Gray Short-Tailed Opossum (Monodelphis Domestica) and North American Opossum (Didelphis Virginiana)
University of Tennessee, Knoxville TRACE: Tennessee Research and Creative Exchange Doctoral Dissertations Graduate School 12-2001 Comparative Anatomy of the Lower Respiratory Tract of the Gray Short-tailed Opossum (Monodelphis domestica) and North American Opossum (Didelphis virginiana) Lee Anne Cope University of Tennessee - Knoxville Follow this and additional works at: https://trace.tennessee.edu/utk_graddiss Part of the Animal Sciences Commons Recommended Citation Cope, Lee Anne, "Comparative Anatomy of the Lower Respiratory Tract of the Gray Short-tailed Opossum (Monodelphis domestica) and North American Opossum (Didelphis virginiana). " PhD diss., University of Tennessee, 2001. https://trace.tennessee.edu/utk_graddiss/2046 This Dissertation is brought to you for free and open access by the Graduate School at TRACE: Tennessee Research and Creative Exchange. It has been accepted for inclusion in Doctoral Dissertations by an authorized administrator of TRACE: Tennessee Research and Creative Exchange. For more information, please contact [email protected]. To the Graduate Council: I am submitting herewith a dissertation written by Lee Anne Cope entitled "Comparative Anatomy of the Lower Respiratory Tract of the Gray Short-tailed Opossum (Monodelphis domestica) and North American Opossum (Didelphis virginiana)." I have examined the final electronic copy of this dissertation for form and content and recommend that it be accepted in partial fulfillment of the equirr ements for the degree of Doctor of Philosophy, with a major in Animal Science. Robert W. Henry, Major Professor We have read this dissertation and recommend its acceptance: Dr. R.B. Reed, Dr. C. Mendis-Handagama, Dr. J. Schumacher, Dr. S.E. Orosz Accepted for the Council: Carolyn R. -
Pediatrics-EOR-Outline.Pdf
DERMATOLOGY – 15% Acne Vulgaris Inflammatory skin condition assoc. with papules & pustules involving pilosebaceous units Pathophysiology: • 4 main factors – follicular hyperkeratinization with plugging of sebaceous ducts, increased sebum production, Propionibacterium acnes overgrowth within follicles, & inflammatory response • Hormonal activation of pilosebaceous glands which may cause cyclic flares that coincide with menstruation Clinical Manifestations: • In areas with increased sebaceous glands (face, back, chest, upper arms) • Stage I: Comedones: small, inflammatory bumps from clogged pores - Open comedones (blackheads): incomplete blockage - Closed comedones (whiteheads): complete blockage • Stage II: Inflammatory: papules or pustules surrounded by inflammation • Stage III: Nodular or cystic acne: heals with scarring Differential Diagnosis: • Differentiate from rosacea which has no comedones** • Perioral dermatitis based on perioral and periorbital location • CS-induced acne lacks comedones and pustules are in same stage of development Diagnosis: • Mild: comedones, small amounts of papules &/or pustules • Moderate: comedones, larger amounts of papules &/or pustules • Severe: nodular (>5mm) or cystic Management: • Mild: topical – azelaic acid, salicylic acid, benzoyl peroxide, retinoids, Tretinoin topical (Retin A) or topical antibiotics [Clindamycin or Erythromycin with Benzoyl peroxide] • Moderate: above + oral antibiotics [Minocycline 50mg PO qd or Doxycycline 100 mg PO qd], spironolactone • Severe (refractory nodular acne): oral -
The Reproductive System
27 The Reproductive System PowerPoint® Lecture Presentations prepared by Steven Bassett Southeast Community College Lincoln, Nebraska © 2012 Pearson Education, Inc. Introduction • The reproductive system is designed to perpetuate the species • The male produces gametes called sperm cells • The female produces gametes called ova • The joining of a sperm cell and an ovum is fertilization • Fertilization results in the formation of a zygote © 2012 Pearson Education, Inc. Anatomy of the Male Reproductive System • Overview of the Male Reproductive System • Testis • Epididymis • Ductus deferens • Ejaculatory duct • Spongy urethra (penile urethra) • Seminal gland • Prostate gland • Bulbo-urethral gland © 2012 Pearson Education, Inc. Figure 27.1 The Male Reproductive System, Part I Pubic symphysis Ureter Urinary bladder Prostatic urethra Seminal gland Membranous urethra Rectum Corpus cavernosum Prostate gland Corpus spongiosum Spongy urethra Ejaculatory duct Ductus deferens Penis Bulbo-urethral gland Epididymis Anus Testis External urethral orifice Scrotum Sigmoid colon (cut) Rectum Internal urethral orifice Rectus abdominis Prostatic urethra Urinary bladder Prostate gland Pubic symphysis Bristle within ejaculatory duct Membranous urethra Penis Spongy urethra Spongy urethra within corpus spongiosum Bulbospongiosus muscle Corpus cavernosum Ductus deferens Epididymis Scrotum Testis © 2012 Pearson Education, Inc. Anatomy of the Male Reproductive System • The Testes • Testes hang inside a pouch called the scrotum, which is on the outside of the body -
E Pleura and Lungs
Bailey & Love · Essential Clinical Anatomy · Bailey & Love · Essential Clinical Anatomy Essential Clinical Anatomy · Bailey & Love · Essential Clinical Anatomy · Bailey & Love Bailey & Love · Essential Clinical Anatomy · Bailey & Love · EssentialChapter Clinical4 Anatomy e pleura and lungs • The pleura ............................................................................63 • MCQs .....................................................................................75 • The lungs .............................................................................64 • USMLE MCQs ....................................................................77 • Lymphatic drainage of the thorax ..............................70 • EMQs ......................................................................................77 • Autonomic nervous system ...........................................71 • Applied questions .............................................................78 THE PLEURA reections pass laterally behind the costal margin to reach the 8th rib in the midclavicular line and the 10th rib in the The pleura is a broelastic serous membrane lined by squa- midaxillary line, and along the 12th rib and the paravertebral mous epithelium forming a sac on each side of the chest. Each line (lying over the tips of the transverse processes, about 3 pleural sac is a closed cavity invaginated by a lung. Parietal cm from the midline). pleura lines the chest wall, and visceral (pulmonary) pleura Visceral pleura has no pain bres, but the parietal pleura covers -
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Cartilage Development and Maturation In Vitro and In Vivo Johnathan Ng Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Graduate School of Arts and Sciences Columbia University 2017 © 2017 Johnathan Ng All rights reserved Abstract Cartilage Development and Maturation In Vitro and In Vivo Johnathan Ng The articular cartilage has a limited capacity to regenerate. Cartilage lesions often result in degeneration, leading to osteoarthritis. Current treatments are mostly palliative and reparative, and fail to restore cartilage function in the long term due to the replacement of hyaline cartilage with fibrocartilage. Although a stem-cell based approach towards regenerating the articular cartilage is attractive, cartilage generated from human mesenchymal stem cells (hMSCs) often lack the function, organization and stability of the native cartilage. Thus, there is a need to develop effective methods to engineer physiologic cartilage tissues from hMSCs in vitro and assess their outcomes in vivo. This dissertation focused on three coordinated aims: establish a simple in vivo model for studying the maturation of osteochondral tissues by showing that subcutaneous implantation in a mouse recapitulates native endochondral ossification (Aim 1), (ii) develop a robust method for engineering physiologic cartilage discs from self-assembling hMSCs (Aim 2), and (iii) improve the organization and stability of cartilage discs by implementing spatiotemporal control during induction in vitro (Aim 3). First, the usefulness of subcutaneous implantation in mice for studying the development and maintenance of osteochondral tissues in vivo was determined. By studying juvenile bovine osteochondral tissues, similarities in the profiles of endochondral ossification between the native and ectopic processes were observed. -
ANATOMY of EAR Basic Ear Anatomy
ANATOMY OF EAR Basic Ear Anatomy • Expected outcomes • To understand the hearing mechanism • To be able to identify the structures of the ear Development of Ear 1. Pinna develops from 1st & 2nd Branchial arch (Hillocks of His). Starts at 6 Weeks & is complete by 20 weeks. 2. E.A.M. develops from dorsal end of 1st branchial arch starting at 6-8 weeks and is complete by 28 weeks. 3. Middle Ear development —Malleus & Incus develop between 6-8 weeks from 1st & 2nd branchial arch. Branchial arches & Development of Ear Dev. contd---- • T.M at 28 weeks from all 3 germinal layers . • Foot plate of stapes develops from otic capsule b/w 6- 8 weeks. • Inner ear develops from otic capsule starting at 5 weeks & is complete by 25 weeks. • Development of external/middle/inner ear is independent of each other. Development of ear External Ear • It consists of - Pinna and External auditory meatus. Pinna • It is made up of fibro elastic cartilage covered by skin and connected to the surrounding parts by ligaments and muscles. • Various landmarks on the pinna are helix, antihelix, lobule, tragus, concha, scaphoid fossa and triangular fossa • Pinna has two surfaces i.e. medial or cranial surface and a lateral surface . • Cymba concha lies between crus helix and crus antihelix. It is an important landmark for mastoid antrum. Anatomy of external ear • Landmarks of pinna Anatomy of external ear • Bat-Ear is the most common congenital anomaly of pinna in which antihelix has not developed and excessive conchal cartilage is present. • Corrections of Pinna defects are done at 6 years of age. -
Eustachian Tube Catheterization. J Otolaryngol ENT Res
Journal of Otolaryngology-ENT Research Editorial Open Access Eustachian tube catheterization Volume 3 Issue 2 - 2015 Hee-Young Kim Introduction Otorhinolaryngology, Kim ENT clinic, Republic of Korea Although Eustachian tube obstruction (ETO) as one of the principal Correspondence: Hee-Young Kim, Otorhinolaryngology, Kim causes of ‘hearing loss’, and/or ‘ear fullness’, and/or ‘tinnitus’, and/ ENT Clinic, 2nd fl. 119, Jangseungbaegi-ro, Dongjak-gu, Seoul, 06935, Republic of Korea, Tel +82-02-855-7541, or ‘headache (including otalgia)’, and/or ‘vertigo’, has already been Email recognized by many well-respected senior doctors for a long time, it has still received only scant attention both in the literature and in Received: September 02, 2015 | Published: September 14, practice.1,2 2015 Pressure differences between the middle ear and the atmosphere cause temporary conductive hearing loss by decreased motion of the tympanic membrane and ossicles of the ear.3 This point includes clue for explaining the mechanism of tinnitus due to Eustachian tube obstruction.1 Improvement of tinnitus after Eustachian tube catheterization, can mean that the tinnitus is from the hypersensitivity of cochlear nucleus following decrease of afferent nerve stimuli owing to air-bone gap.1,4 The middle ear is very much like a specialized paranasal sinus, with normal balance as maintained by the labyrinthine mechanism.7 called the tympanic cavity; it, like the paranasal sinuses, is a hollow There are many other conditions which may cause vertigo, but since mucosa-lined cavity in the skull that is ventilated through the nose.5 Eustachian tube obstruction is one of the most obvious, and also the Tympanic cavity and mastoid cavity are named on the basis of most easily corrected, every patient with symptoms of vertigo, and/or anatomy.