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Haemophilia: Recent History of Clinical Management
HAEMOPHILIA: RECENT HISTORY OF CLINICAL MANAGEMENT The transcript of a Witness Seminar held at the Wellcome Institute for the History of Medicine, London, on 10 February 1998 Edited by D A Christie and E M Tansey HAEMOPHILIA: RECENT HISTORY OF CLINICAL MANAGEMENT Participants Dr Derek Bangham Professor Ilsley Ingram Dr Ethel Bidwell Dr Peter Jones Sir Christopher Booth Professor Christine Lee (Chair) Dr Brian Colvin Dr James Matthews Dr Angela Dike Mrs Riva Miller Mr Ross Dike Dr Charles Rizza Dr Helen Dodsworth Rev Alan Tanner Professor Stuart Douglas* Dr Tilli Tansey Professor Robert Duthie Professor Edward Tuddenham Dr David Evans Dr David Tyrrell Dr Sheila Howarth Mr Clifford Welch Others present at the meeting: Dr Trevor Barrowcliffe, Ms Jacqui Marr, Dr J K Smith, Miss Rosemary Spooner Apologies: Professor Jean-Pierre Allain, Dr Donald Bateman, Dr Rosemary Biggs, Mrs Peggy Britten,** Professor Judith Chessells, Dr Audrey Dawson, Mr Ron Hutton, Professor Ralph Kekwick, Professor Sir David Weatherall *Deceased 15 November 1998 **Deceased 1 March 1999 2 Haemophilia: Recent history Professor Christine Lee:1 I think haemophilia is one of the best areas of clinical medicine where we have seen a very rapid introduction of scientific discovery into clinical practice. All of us who work on haemophilia realize that this has gone on very much with cooperation between the patients and the scientists and the doctors. I first saw haemophilia in 1967 when I was a medical student in Oxford and we were doing our orthopaedics at the Nuffield Orthopaedic Hospital. I have a very clear memory of a ward of little boys with their legs strung up, their arms strung up, and I think there was a schoolroom nearby. -
Clinical Pharmacology in the UK, C. 1950–2000: Industry and Regulation
CLINICAL PHARMACOLOGY IN THE UK, c. 1950–2000: INDUSTRY AND REGULATION The transcript of a Witness Seminar held by the Wellcome Trust Centre for the History of Medicine at UCL, London, on 25 September 2007 Edited by L A Reynolds and E M Tansey Volume 34 2008 ©The Trustee of the Wellcome Trust, London, 2008 First published by the Wellcome Trust Centre for the History of Medicine at UCL, 2008 The Wellcome Trust Centre for the History of Medicine at UCL is funded by the Wellcome Trust, which is a registered charity, no. 210183. ISBN 978 085484 118 9 All volumes are freely available online at: www.history.qmul.ac.uk/research/modbiomed/wellcome_witnesses/ Please cite as: Reynolds L A, Tansey E M. (eds) (2008) Clinical Pharmacology in the UK c.1950-2000: Industry and regulation. Wellcome Witnesses to Twentieth Century Medicine, vol. 34. London: Wellcome Trust Centre for the History of Medicine at UCL. CONTENTS Illustrations and credits v Abbreviations vii Witness Seminars: Meetings and publications; Acknowledgements E M Tansey and L A Reynolds ix Introduction Professor Parveen Kumar xxiii Transcript Edited by L A Reynolds and E M Tansey 1 References 73 Biographical notes 89 Glossary 103 Index 109 ILLUSTRATIONS AND CREDITS Figure 1 AstraZeneca Clinical Trials Unit, South Manchester. Reproduced by permission of AstraZeneca. 6 Figure 2 A summary of the organization of clinical trials. Adapted from www.clinicaltrials.gov/ct2/info/glossary (visited 1 May 2008). 10 Figure 3 Clinical trial certificates (CTC) and clinical trial exemption (CTX), 1972–1985. Adapted from Speirs (1983) and Speirs (1984). -
Generative Models, Structural Similarity, and Mental Representation
The Mind as a Predictive Modelling Engine: Generative Models, Structural Similarity, and Mental Representation Daniel George Williams Trinity Hall College University of Cambridge This dissertation is submitted for the degree of Doctor of Philosophy August 2018 The Mind as a Predictive Modelling Engine: Generative Models, Structural Similarity, and Mental Representation Daniel Williams Abstract I outline and defend a theory of mental representation based on three ideas that I extract from the work of the mid-twentieth century philosopher, psychologist, and cybernetician Kenneth Craik: first, an account of mental representation in terms of idealised models that capitalize on structural similarity to their targets; second, an appreciation of prediction as the core function of such models; and third, a regulatory understanding of brain function. I clarify and elaborate on each of these ideas, relate them to contemporary advances in neuroscience and machine learning, and favourably contrast a predictive model-based theory of mental representation with other prominent accounts of the nature, importance, and functions of mental representations in cognitive science and philosophy. For Marcella Montagnese Preface Declaration This dissertation is the result of my own work and includes nothing which is the outcome of work done in collaboration except as declared in the Preface and specified in the text. It is not substantially the same as any that I have submitted, or, is being concurrently submitted for a degree or diploma or other qualification at the University of Cambridge or any other University or similar institution except as declared in the Preface and specified in the text. I further state that no substantial part of my dissertation has already been submitted, or, is being concurrently submitted for any such degree, diploma or other qualification at the University of Cambridge or any other University or similar institution except as declared in the Preface and specified in the text. -
Richard Gregory Pri- 1970 He Moved to the University of Bristol, Where He 19 Marily from His Small 1966 Masterpiece Eye and Brain Remained for the Rest of His Career
1 2 3 4 5 6 7 8 9 Obituary 10 11 ALFRED H. FUCHS, EDITOR 12 Bowdoin College 13 14 15 16 17 RICHARD LANGTON GREGORy (1923–2010) 18 19 20 21 BRUCE BRIDGEMAN 22 University of California, Santa Cruz 23 A giant among cognitive scientists, Richard L. Gregory died on May 17th at the age 24 of 86. While most of us remember him for his pioneering work in perception, he 25 had many other interests and accomplishments as well. Though I knew him only 26 late in his life, he always had a spark of boyish curiosity and enthusiasm. Gregory 27 had a way of cocking his head and looking down at his conversation partners; with 28 his height, he looked down at almost everyone, literally but never figuratively. He 29 must have been born tall—it’s impossible to imagine him any other way. 30 Gregory was born into an academic family. His father Christopher was the first 31 director of the University of London Observatory, and he attended a public school 32 (in North America, a private school). His education was interrupted by WWII, 33 during which he served in the signals branch of the Royal Air Force. Continuing on 34 the academic fast track, in 1947 he entered Downing College, Cambridge, studying 35 philosophy and experimental psychology, tutored by Bertrand Russell in the small 36 world of British academia at the time. After earning his degree in 1950, he stayed 37 in Cambridge to work at the Medical Research Council applied psychology unit 38 under Frederic Bartlett, one of Bartlett’s last students and, for Gregory, one of his 39 most treasured mentors. -
Cognitive Psychology
COGNITIVE PSYCHOLOGY PSYCH 126 Acknowledgements College of the Canyons would like to extend appreciation to the following people and organizations for allowing this textbook to be created: California Community Colleges Chancellor’s Office Chancellor Diane Van Hook Santa Clarita Community College District College of the Canyons Distance Learning Office In providing content for this textbook, the following professionals were invaluable: Mehgan Andrade, who was the major contributor and compiler of this work and Neil Walker, without whose help the book could not have been completed. Special Thank You to Trudi Radtke for editing, formatting, readability, and aesthetics. The contents of this textbook were developed under the Title V grant from the Department of Education (Award #P031S140092). However, those contents do not necessarily represent the policy of the Department of Education, and you should not assume endorsement by the Federal Government. Unless otherwise noted, the content in this textbook is licensed under CC BY 4.0 Table of Contents Psychology .................................................................................................................................................... 1 126 ................................................................................................................................................................ 1 Chapter 1 - History of Cognitive Psychology ............................................................................................. 7 Definition of Cognitive Psychology -
Richard L. Gregory (March 7Th 2000) ADVENTURES of a MAVERICK in the Beginning--School and War My Father Was a Scientist--An
Richard L. Gregory (March 7th 2000) ADVENTURES OF A MAVERICK In the Beginning--School and war My father was a scientist--an astronomer--being the first director of the University of London Observatory. So I was brought up with optical instruments and also with the importance of making observations. My father measured the distances of the nearer stars for most of his life-- using parallax from camera-positions separated by the 186,000,000 miles diameter of the Earthís orbit around the Sun. These measurements are crucial for scaling the universe. Is it an accident that years later I tried to scale and explain distortions of visual space? At school I learned simple electronics in our Radio Club, as we built our own short wave receivers, and then more in the RAF at Number One Signal School at Cranwell. Cranwell had excellent teaching, and was highly civilised, with its drama and music societies. I should have been posted to the Gold Coast, but a telegram recalling me from Christmas leave did not arrive in time so I was posted to Training Command in Canada. This was a year flying around the Bay of Fundy and St Johns, sometimes testing radio communications and radar; then six months with the Fleet Air Arm at Kingston, Ontario, where I had my own boat and sailed among the Thousand Islands. During almost six years in the RAF I had time to read and think on physics and biology, and wrote a science column in a local RAF magazine. I also read C.G. Jung (developing a permanent allergy) and William James (who remains a hero.) No doubt I absorbed some useful concepts from the technologies of radio and radar. -
Harper, Peter: Transcript of a Video Interview (06-Jun-2015)
History of Modern Biomedicine Research Group School of History, Queen Mary University of London Mile End Road, London E1 4NS website: www.histmodbiomed.org VIDEO INTERVIEW TRANSCRIPT Harper, Peter: transcript of a video interview (06-Jun-2015) Interviewer: Tilli Tansey Transcriber: Debra Gee Editors: Tilli Tansey, Alan Yabsley Date of publication: 20-Mar-2017 Date and place of interview: 06-Jun-2015; Glasgow Publisher: Queen Mary University of London Collection: History of Modern Biomedicine Interviews (Digital Collection) Reference: e2017093 Number of pages: 4 DOI: 10.17636/01021439 Acknowledgments: The project management of Mr Adam Wilkinson is gratefully acknowledged. The History of Modern Biomedicine Research Group is funded by the Wellcome Trust, which is a registered charity (no. 210183). The current interview has been funded by the Wellcome Trust Strategic Award entitled “Makers of modern biomedicine: testimonies and legacy” (2012-2017; awarded to Professor Tilli Tansey). Citation: Tansey E M (intvr); Tansey E M, Yabsley A (eds) (2017) Harper, Peter: transcript of a video interview (06-Jun- 2015). History of Modern Biomedicine Interviews (Digital Collection), item e2017093. London: Queen Mary University of London. Related resources: items 2017094 - 2017099, History of Modern Biomedicine Interviews (Digital Collection) Note: Video interviews are conducted following standard oral history methodology, and have received ethical approval (reference QMREC 0642). Video interview transcripts are edited only for clarity and factual accuracy. Related material has been deposited in the Wellcome Library. © The Trustee of the Wellcome Trust, London, 2017 History of Modern Biomedicine Interviews (Digital Collection) - Harper, P e2017093 | 2 Harper, Peter: transcript of a video interview (06-Jun-2015)* Biography: Professor Peter Harper (b. -
Sir Frederic Bartlett, the Bartlett Lecture and an Unwanted K
Title: Sir Frederic Bartlett, the Bartlett lecture and an unwanted k Author: Alan F. Collins Running head: The Bartlett lecture Address: Department of Psychology, Lancaster University Lancaster LA1 4YF UK 1 Sir Frederic Bartlett, the Bartlett lecture and an unwanted k Sir Frederic Charles Bartlett was born on 20th of October 1886 in Stow-on-the-Wold, Gloucestershire, England. He became one of the most well known psychologists of the twentieth century. And it is absolutely clear from his birth certificate, which I have in front of me as I write, that his first name was spelt without a final k. His major publications also repeatedly attest to the lack of a terminal ‘k’. Yet, as a quick search through Google Scholar will readily confirm, he is often mistakenly cited as Frederick Bartlett. Perhaps the occasional error in research articles can be allowed but it is more embarrassing when an honorary lecture named after Bartlett has been repeatedly referred to as the Sir Frederick Bartlett lecture. On February 24, 2015 the Editor of QJEP received an email from the production manager, informing him that the author of that year’s Experimental Psychology Society Bartlett Lecture, Gordon Logan, had submitted corrections to his proofs in which he asked to amend ‘The 42nd Sir Frederick Bartlett Lecture’ to ‘The 42nd Sir Frederic Bartlett Lecture’ (Logan, 2015).1 The production team then noted a discrepancy between Logan’s (correct) spelling and spellings of Bartlett’s first name in many earlier publications of the lecture in QJEP. Rather than ignore this discovery, or brush this under the publication carpet, it was felt appropriate that the Journal record a reflection on this event as well as resolve not to repeat the error in future. -
Genetic Testing
GENETIC TESTING The transcript of a Witness Seminar held by the Wellcome Trust Centre for the History of Medicine at UCL, London, on 13 July 2001 Edited by D A Christie and E M Tansey Volume 17 2003 CONTENTS Illustrations v Introduction Professor Peter Harper vii Acknowledgements ix Witness Seminars: Meetings and publications xi E M Tansey and D A Christie Transcript Edited by D A Christie and E M Tansey 1 References 73 Biographical notes 91 Glossary 105 Index 115 ILLUSTRATIONS Figure 1 Triploid cells in a human embryo, 1961. 20 Figure 2 The use of FISH with DNA probes from the X and Y chromosomes to sex human embryos. 62 v vi INTRODUCTION Genetic testing is now such a widespread and important part of medicine that it is hard to realize that it has almost all emerged during the past 30 years, with most of the key workers responsible for the discoveries and development of the field still living and active. This alone makes it a suitable subject for a Witness Seminar but there are others that increase its value, notably the fact that a high proportion of the critical advances took place in the UK; not just the basic scientific research, but also the initial applications in clinical practice, particularly those involving inherited disorders. To see these topics discussed by the people who were actually involved in their creation makes fascinating reading; for myself it is tinged with regret at having been unable to attend and contribute to the seminar, but with some compensation from being able to look at the contributions more objectively than can a participant. -
Applied History of Psychology/History of Research on Attention 1 Applied History of Psychology/History of Research on Attention
Applied History of Psychology/History of Research on Attention 1 Applied History of Psychology/History of Research on Attention There has been a large increase in research activity in the area of attention since the 1950s. This research has focused not only on attention, but also how attention is related to memory and executive functioning. Human learning and behaviour are dependent on our ability to pay attention to our environment, retain and retrieve information, and use cognitive strategies. An understanding of the development of attention is also critical when we consider that deficits in attention often lead to difficulties in school and in the work force. Thus, attention is an important topic in the study of psychology, specifically in the areas of development (see Part II of this book), learning (Part III), and psychological disorders (see the section on ADHD in Part IV). There is no doubt that an understanding of attention and related concepts is critical to our understanding of human cognition and learning. Introduction to The History of Research on Attention The study of attention is a major part of contemporary cognitive psychology and cognitive neuroscience. Attention plays a critical role in essentially all aspects of perception, cognition, and action, influencing the choices we make. The study of attention has been of interest to the field of psychology since its earliest days. However, many ideas about attention can be traced to philosophers in the 18th and 19th centuries, preceding the foundation of the field of psychology. The topic of attention was originally discussed by philosophers. Among the issues considered were the role of attention on conscious awareness and thought, and whether attention was directed voluntarily or involuntarily toward objects or events. -
9-11Th July 2014
INTERNATIONAL CONFERENCE ON WORKING MEMORY th 9-11 July 2014 PROGRAMME Presentations, posters, lunches: University Arms Hotel, Regent Street, Cambridge, CB2 1AD Evening reception (9th July): MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge, CB2 7EF Conference Dinner (10th July, pre-booked places only): Trinity Hall, Trinity Lane, Cambridge, CB2 1TJ ICWM2014 DRAFT PROGRAMME Page 1 Wednesday 9th July – Afternoon and reception 12pm Registration at the University Arms Hotel 12-2pm Poster session I and Lunch, Mezzanine Presentations, Session I, Main room: 2.00pm Susan Gathercole (Cognition and Brain Sciences Unit) Introduction to ICWM 2.05pm Alan Baddeley (University of York) Working memory at 40 2.50pm Pierre Barrouillet (University of Geneva) Loss of information from working memory 3.10pm Valerie Camos (University of Fribourg) The mechanisms of reconstruction in working memory 3.30pm Andrew Conway (Princeton University) Process Overlap Theory: A new interpretation of working memory capacity 3.50pm Refreshments 4.20pm Michael Kane (University of North Carolina at Greensboro) Convergent and discriminant validity of working memory capacity (or, how null results can be the theorist’s friend 4.40pm Klaus Oberauer (University of Zurich) Removal of distractors in complex working memory span tasks 5.00pm John Towse (Lancaster University) The development of working memory capacity: exactly which problems are we trying to solve? 5.20pm Nelson Cowan (University of Missouri) Working memory for the amount of change in an array 6-8pm -
Human Functional Brain Imaging 1990–2009
Portfolio Review Human Functional Brain Imaging 1990–2009 September 2011 Acknowledgements The Wellcome Trust would like to thank the many people who generously gave up their time to participate in this review. The project was led by Claire Vaughan and Liz Allen. Key input and support was provided by Lynsey Bilsland, Richard Morris, John Williams, Shewly Choudhury, Kathryn Adcock, David Lynn, Kevin Dolby, Beth Thompson, Anna Wade, Suzi Morris, Annie Sanderson, and Jo Scott; and Lois Reynolds and Tilli Tansey (Wellcome Trust Expert Group). The views expressed in this report are those of the Wellcome Trust project team, drawing on the evidence compiled during the review. We are indebted to the independent Expert Group and our industry experts, who were pivotal in providing the assessments of the Trust’s role in supporting human functional brain imaging and have informed ‘our’ speculations for the future. Finally, we would like to thank Professor Randy Buckner, Professor Ray Dolan and Dr Anne-Marie Engel, who provided valuable input to the development of the timelines and report. The2 | Portfolio Wellcome Review: Trust Human is a Functional charity registeredBrain Imaging in England and Wales, no. 210183. Contents Acknowledgements 2 Key abbreviations used in the report 4 Overview and key findings 4 Landmarks in human functional brain imaging 10 1. Introduction and background 12 2 Human functional brain imaging today: the global research landscape 14 2.1 The global scene 14 2.2 The UK 15 2.3 Europe 17 2.4 Industry 17 2.5 Human brain imaging