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Studies Describing Baseline Dialysate Concentrations for Asparagine

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Appendix 1: Studies describing baseline dialysate concentrations for asparagine Asparagine Authors Title Year Vol Pages Journal Abraham, I.; Juhasz, G.; Kekesi, K. A.; Corticosterone peak is responsible for stress-induced elevation of 1998 2 171-181 Stress Kovacs, K. J. glutamate in the hippocampus Abraham, I.; Juhasz, G.; Kekesi, K. A.; Effect of intrahippocampal dexamethasone on the levels of amino 1996 733 56-63 Brain Res Kovacs, K. J. acid transmitters and neuronal excitability Acworth, I. N.; Yu, J.; Ryan, E.; Gariepy, K. Simultaneous measurement of monoamine, amino acid, and drug 1994 17 685-705 J Liq Chromatogr C.; Gamache, P.; Hull, K.; Maher, T. levels, using high performance liquid chromatography and coulometric array technology: Application to in vivo microdialysis perfusate analysis Andine, P.; Orwar, O.; Jacobson, I.; Changes in extracellular amino acids and spontaneous neuronal 1991 57 222-229 J Neurochem Sandberg, M.; Hagberg, H. activity during ischemia and extended reflow in the CA1 of the rat hippocampus Bereiter, D. A.; Shen, S.; Benetti, A. P. Sex differences in amino acid release from rostral trigeminal 2002 98 89-99 Pain subnucleus caudalis after acute injury to the TMJ region Boyd, B. W.; Witowski, S. R.; Kennedy, R. T. Trace-level amino acid analysis by capillary liquid chromatography 2000 72 865-871 Anal Chem and application to in vivo microdialysis sampling with 10-s temporal resolution Buisson, A.; Callebert, J.; Mathieu, E.; Striatal protection induced by lesioning the substantia nigra of rats 1992 59 1153- J Neurochem Plotkine, M.; Boulu, R. G. subjected to focal ischemia 1157 Butcher, S. P.; Hamberger, A. In vivo studies on the extracellular, and veratrine-releasable, pools 1987 48 713-721 J Neurochem of endogenous amino acids in the rat striatum: effects of corticostriatal deafferentation and kainic acid lesion Butcher, S. P.; Jacobson, I.; Hamberger, A. On the epileptogenic effects of kainic acid and dihydrokainic acid in 1988 27 375-381 Neuropharmacol the dentate gyrus of the rat Butcher, S. P.; Lazarewicz, J. W.; In vivo microdialysis studies on the effects of decortication and 1987 49 1355- J Neurochem Hamberger, A. excitotoxic lesions on kainic acid-induced calcium fluxes, and 1360 endogenous amino acid release, in the rat striatum Butcher, S. P.; Sandberg, M.; Hagberg, H.; Cellular origins of endogenous amino acids released into the 1987 48 722-728 J Neurochem Hamberger, A. extracellular fluid of the rat striatum during severe insulin-induced hypoglycemia Choi, Y. H.; Chang, N.; Fletcher, P. J.; Dietary protein content affects the profiles of extracellular amino 2000 66 1105- Life Sci Anderson, G. H. acids in the medial preoptic area of freely moving rats 1118 Asparagine Authors Title Year Vol Pages Journal Choi, Y. H.; Fletcher, P. J.; Anderson, G. H. Extracellular amino acid profiles in the paraventricular nucleus of the 2001 892 320-328 Brain Res rat hypothalamus are influenced by diet composition Currie, P. J.; Chang, N.; Luo, S.; Anderson, Microdialysis as a tool to measure dietary and regional effects on 1995 57 1911- Life Sci G. H. the complete profile of extracellular amino acids in the 1923 hypothalamus of rats David, C. N.; Frias, E. S.; Szu, J. I.; Vieira, GLT-1-Dependent Disruption of CNS Glutamate Homeostasis and 2016 12 e1005643 PLoS Pathog P. A.; Hubbard, J. A.; Lovelace, J.; Michael, Neuronal Function by the Protozoan Parasite Toxoplasma gondii M.; Worth, D.; McGovern, K. E.; Ethell, I. M.; Stanley, B. G.; Korzus, E.; Fiacco, T. A.; Binder, D. K.; Wilson, E. H. Dolgodilina, E.; Imobersteg, S.; Laczko, E.; Brain interstitial fluid glutamine homeostasis is controlled by blood- 2016 36 1929- J Cereb Blood Flow Metab Welt, T.; Verrey, F.; Makrides, V. brain barrier SLC7A5/LAT1 amino acid transporter 1941 Fedele, E.; Foster, A. C. An evaluation of the role of extracellular amino acids in the delayed 1993 52 911-917 Neuroscience neurodegeneration induced by quinolinic acid in the rat striatum Fraser, M.; Bennet, L.; Van Zijl, P. L.; Extracellular amino acids and lipid peroxidation products in 2008 105 2214- J Neurochem Mocatta, T. J.; Williams, C. E.; Gluckman, P. periventricular white matter during and after cerebral ischemia in 2223 D.; Winterbourn, C. C.; Gunn, A. J. preterm fetal sheep Gobert, A.; Rivet, J. M.; Billiras, R.; Parsons, Simultaneous quantification of D- vs. L-serine, taurine, kynurenate, 2011 202 143-157 J Neurosci Methods F.; Millan, M. J. phosphoethanolamine and diverse amino acids in frontocortical dialysates of freely-moving rats: differential modulation by N-methyl- D-aspartate (NMDA) and other pharmacological agents Goldsmith, J. D.; Kujawa, S. G.; McLaren, J. In vivo release of neuroactive amino acids from the inferior colliculus 1995 83 80-88 Hear Res D.; Bledsoe Jr, S. C. of the guinea pig using brain microdialysis Gordon, K. E.; Simpson, J.; Statman, D.; Effects of perinatal stroke on striatal amino acid efflux in rats studied 1991 22 928-932 Stroke Silverstein, F. S. with in vivo microdialysis Guerra-Romero, L.; Tureen, J. H.; Fournier, Amino acids in cerebrospinal and brain interstitial fluid in 1993 33 510-513 Pediatr Res M. A.; Makrides, V.; Tauber, M. G. experimental pneumococcal meningitis Haskew-Layton, R. E.; Rudkouskaya, A.; Two distinct modes of hypoosmotic medium-induced release of 2008 3 e3543 PLoS One Jin, Y.; Feustel, P. J.; Kimelberg, H. K.; excitatory amino acids and taurine in the rat brain in vivo Mongin, A. A. Jacobson, I.; Sandberg, M.; Hamberger, A. Mass transfer in brain dialysis devices--a new method for the 1985 15 263-268 J Neurosci Methods estimation of extracellular amino acids concentration Largo, C.; Cuevas, P.; Somjen, G. G.; Martin The effect of depressing glial function in rat brain in situ on ion 1996 16 1219- J Neurosci Asparagine Authors Title Year Vol Pages Journal del Rio, R.; Herreras, O. homeostasis, synaptic transmission, and neuron survival 1229 Lehmann, A. Alterations in hippocampal extracellular amino acids and purine 1987 22 573-578 Neuroscience catabolites during limbic seizures induced by folate injections into the rabbit amygdala Lerma, J.; Herranz, A. S.; Herreras, O. In vivo determination of extracellular concentration of amino acids in 1986 384 145-155 Brain Research the rat hippocampus. A method based on brain dialysis and computerized analysis Li, H.; Yan, Z. Y. Analysis of amino acid neurotransmitters in hypothalamus of rats 2010 24 1185- Biomed Chromatogr during cerebral ischemia-reperfusion by microdialysis and capillary 1192 electrophoresis Li, Z. P.; Zhang, X. Y.; Lu, X.; Zhong, M. K.; Dynamic release of amino acid transmitters induced by valproate in 2004 44 263-270 Neurochem Int Ji, Y. H. PTZ-kindled epileptic rat hippocampus Lo, E. H.; Steinberg, G. K.; Panahian, N.; Profiles of extracellular amino acid changes in focal cerebral 1993 15 281-287 Neurol Res Maidment, N. T.; Newcomb, R. ischaemia: effects of mild hypothermia Malmberg, A. B.; Hamberger, A.; Hedner, T. Effects of prostaglandin E2 and capsaicin on behavior and 1995 65 2185- J Neurochem cerebrospinal fluid amino acid concentrations of unanesthetized 2193 rats: a microdialysis study Mena, F. V.; Baab, P. J.; Zielke, C. L.; In vivo glutamine hydrolysis in the formation of extracellular 2000 60 632-641 J Neurosci Res Zielke, H. R. glutamate in the injured rat brain Miyashita, K.; Abe, H.; Nakajima, T.; Glutamate release in the gerbil hippocampus after middle cerebral 1994 5 945-948 Neuroreport Ishikawa, A.; Nishiura-Suzuki, M.; Naritomi, artery occlusion H.; Tanaka, R.; Sawada, T. Molchanova, S.; Kbi, P.; Oja, S. S.; Interstitial concentrations of amino acids in the rat striatum during 2004 29 1519- Neurochem Res Saransaari, P. global forebrain ischemia and potassium-evoked spreading 1527 depression Morita, T.; Takahashi, M.; Takeuchi, T.; Changes in extracellular neurotransmitters in the cerebrum of 2005 67 1119- J Vet Med Sci Hikasa, Y.; Ikeda, S.; Sawada, M.; Sato, K.; familial idiopathic epileptic shetland sheepdogs using an 1126 Shibahara, T.; Shimada, A. intracerebral microdialysis technique and immunohistochemical study for glutamate metabolism Newcomb, R.; Palma, A. Effects of diverse omega-conopeptides on the in vivo release of 1994 638 95-102 Brain Res glutamic and gamma-aminobutyric acids Nilsson, P.; Hillered, L.; Ponten, U.; Changes in cortical extracellular levels of energy-related metabolites 1990 10 631-637 J Cereb Blood Flow Metab Ungerstedt, U. and amino acids following concussive brain injury in rats Asparagine Authors Title Year Vol Pages Journal Nilsson, P.; Ronne-Engstrom, E.; Flink, R.; Epileptic seizure activity in the acute phase following cortical impact 1994 637 227-232 Brain Res Ungerstedt, U.; Carlson, H.; Hillered, L. trauma in rat Qu, Y.; Li, Y.; Vandenbussche, E.; In vivo microdialysis in the visual cortex of awake cat. II: sample 2001 7 45-51 Brain Res Brain Res Protoc Vandesande, F.; Arckens, L. analysis by microbore HPLC-electrochemical detection and capillary electrophoresis-laser-induced fluorescence detection Qureshi, A. I.; Ali, Z.; Suri, M. F.; Shuaib, A.; Extracellular glutamate and other amino acids in experimental 2003 31 182-189 Crit Care Med Baker, G.; Todd, K.; Guterman, L. R.; intracerebral hemorrhage: an in vivo microdialysis study Hopkins, L. N. Radhakrishnan, R.; Sluka, K. A. Increased glutamate and decreased glycine release in the rostral 2009 457 141-145 Neurosci Lett ventromedial medulla during induction of a pre-clinical model of chronic widespread muscle pain Renno, W. M.; Mullet, M. A.; Williams, F. G.; Construction of 1 mm microdialysis probe for amino acids dialysis in 1998 79 217-228 J Neurosci Methods Beitz, A. J. rats Sandberg, M.; Butcher, S. P.; Hagberg, H. Extracellular overflow of neuroactive amino acids during severe 1986 47 178-184 J Neurochem insulin-induced hypoglycemia: in vivo dialysis of the rat hippocampus Sheng, W.; Hang, H. W.; Ruan, D. Y. In vivo microdialysis study of the relationship between lead-induced 2005 20 233-240 Environ Toxicol Pharmacol impairment of learning and neurotransmitter changes in the hippocampus Silverstein, F.
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    Drug Name Plate Number Well Location % Inhibition, Screen Axitinib 1 1 20 Gefitinib (ZD1839) 1 2 70 Sorafenib Tosylate 1 3 21 Crizotinib (PF-02341066) 1 4 55 Docetaxel 1 5 98 Anastrozole 1 6 25 Cladribine 1 7 23 Methotrexate 1 8 -187 Letrozole 1 9 65 Entecavir Hydrate 1 10 48 Roxadustat (FG-4592) 1 11 19 Imatinib Mesylate (STI571) 1 12 0 Sunitinib Malate 1 13 34 Vismodegib (GDC-0449) 1 14 64 Paclitaxel 1 15 89 Aprepitant 1 16 94 Decitabine 1 17 -79 Bendamustine HCl 1 18 19 Temozolomide 1 19 -111 Nepafenac 1 20 24 Nintedanib (BIBF 1120) 1 21 -43 Lapatinib (GW-572016) Ditosylate 1 22 88 Temsirolimus (CCI-779, NSC 683864) 1 23 96 Belinostat (PXD101) 1 24 46 Capecitabine 1 25 19 Bicalutamide 1 26 83 Dutasteride 1 27 68 Epirubicin HCl 1 28 -59 Tamoxifen 1 29 30 Rufinamide 1 30 96 Afatinib (BIBW2992) 1 31 -54 Lenalidomide (CC-5013) 1 32 19 Vorinostat (SAHA, MK0683) 1 33 38 Rucaparib (AG-014699,PF-01367338) phosphate1 34 14 Lenvatinib (E7080) 1 35 80 Fulvestrant 1 36 76 Melatonin 1 37 15 Etoposide 1 38 -69 Vincristine sulfate 1 39 61 Posaconazole 1 40 97 Bortezomib (PS-341) 1 41 71 Panobinostat (LBH589) 1 42 41 Entinostat (MS-275) 1 43 26 Cabozantinib (XL184, BMS-907351) 1 44 79 Valproic acid sodium salt (Sodium valproate) 1 45 7 Raltitrexed 1 46 39 Bisoprolol fumarate 1 47 -23 Raloxifene HCl 1 48 97 Agomelatine 1 49 35 Prasugrel 1 50 -24 Bosutinib (SKI-606) 1 51 85 Nilotinib (AMN-107) 1 52 99 Enzastaurin (LY317615) 1 53 -12 Everolimus (RAD001) 1 54 94 Regorafenib (BAY 73-4506) 1 55 24 Thalidomide 1 56 40 Tivozanib (AV-951) 1 57 86 Fludarabine
  • Diagnosis and Treatment of Parkinson Disease: Molecules to Medicine

    Diagnosis and Treatment of Parkinson Disease: Molecules to Medicine

    Diagnosis and treatment of Parkinson disease: molecules to medicine Joseph M. Savitt, … , Valina L. Dawson, Ted M. Dawson J Clin Invest. 2006;116(7):1744-1754. https://doi.org/10.1172/JCI29178. Science in Medicine Parkinson disease (PD) is a relatively common disorder of the nervous system that afflicts patients later in life with tremor, slowness of movement, gait instability, and rigidity. Treatment of these cardinal features of the disease is a success story of modern science and medicine, as a great deal of disability can be alleviated through the pharmacological correction of brain dopamine deficiency. Unfortunately these therapies only provide temporary, though significant, relief from early symptoms and do not halt disease progression. In addition, pathological changes outside of the motor system leading to cognitive, autonomic, and psychiatric symptoms are not sufficiently treated by current therapies. Much as the discovery of dopamine deficiency led to powerful treatments for motor symptoms, recent discoveries concerning the role of specific genes in PD pathology will lead to the next revolution in disease therapy. Understanding why and how susceptible cells in motor and nonmotor regions of the brain die in PD is the first step toward preventing this cell death and curing or slowing the disease. In this review we discuss recent discoveries in the fields of diagnosis and treatment of PD and focus on how a better understanding of disease mechanisms gained through the study of monogenetic forms of PD has provided novel therapeutic targets. Find the latest version: https://jci.me/29178/pdf Science in medicine Diagnosis and treatment of Parkinson disease: molecules to medicine Joseph M.