DOCSLIB.ORG

WSC 14-15 Conf 12 Layout

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
WSC 14-15 Conf 12 Layout Joint Pathology Center Veterinary Pathology Services WEDNESDAY SLIDE CONFERENCE 2014-2015 Conference 12 10 December 2014 CASE I: 1734-10 (JPC 4003079). of the pericardial adipose tissue. There were multiple gingival ulcers located where the teeth Signalment: 3-month-old female Holstein- had contact with the buccal mucosa, an acute Friesian calf, Bos Taurus. diffuse purulent rhinitis and a marked bronchopneumonia of the cranioventral lung History: In the flock there was a history of areas. Predominantly at the head and neck, the diarrhea, emaciation and pneumonia. This calf skin showed multifocal well demarcated areas died and was submitted for necropsy. characterized by alopecia, crusts and thickened epidermis. Gross Pathologic Findings: The calf was emaciated (weight 37.5 kg), with serous atrophy 1-1. Haired skin, calf: There is a thick serocellular crust covering a 1-2. Haired skin, calf: There are numerous 2-3 µ m arthrospores focally extensive area of the epidermis. (HE 6X) surrounding the hair shaft and hyphae within the medulla of the hair shaft itself, seen primarily in negative relief. (HE 400X) 1 WSC 2014-2015 s e p t a t i o n (Trichophyton sp.). Often, hair follicles are additionally mildly expanded by clumped keratin (infundibular h y p e r k e r a t o s i s ) . Around blood vessels in the upper dermis is a mild inflammatory infiltrate composed of e o s i n o p h i l s , o f lymphocytes and as w e l l a s o f l e s s e r n e u t r o p h i l s a n d macrophages. Sweat glands are mildly dilated. Contributor’s Morphologic Diagnosis: Haired s k i n : D e r m a t i t i s , p e r i v a s c u l a r , eosinophilic, mild, with 1-3. Haired skin, calf: A silver stain demonstrates the fungal hyphae within the hair shafts. (Photo courtesy of: superficial crusting, Institut fuer Veterinaer-Pathologie, Justus-Liebig-Universitaet Giessen, Frankfurter Str. 96, 35392 Giessen, Germany http://www.uni-giessen.de/cms/fbz/fb10/institute_klinikum/institute/pathologie) (Grocott, 400X) e p i d e r m a l a n d f o l l i c u l a r Laboratory Results: No specific pathogens hyperkeratosis with were identified. Skin was not examined dermatophytes and mites, etiology consistent with microbiologically. Trichophyton verrucosum and Psoroptes ovis. (Dermatophytosis and psoroptic mange) Histopathologic Description: Haired skin: Multifocally affecting the epidermis and dermis, Contributor’s Comment: In the bovine, there is an eosinophilic inflammation. The predominantly Trichophyton verrucosum causes epidermis is covered by thick serocellular crusts ringworm. Other isolates (T. mentagrophytes, T. composed of lamellated eosinophilic material equinum, Microsporum gypseum, M. canis, M. (keratin), karyorrhectic and cellular debris nanum) may also play a role in bovine skin (degenerated eosinophils and neutrophils) and an disease. Outbreaks are often associated with eosinophilic homogenous material (exudate). The crowding with a seasonal increase of cases in fall epidermis is mildly thickened (hyperplasia) and and winter. Lesions have a typical anatomical shows an orthokeratotic hyperkeratosis. On the distribution: the skin of head and neck. Clinical epidermal surface and between the keratin signs are pruritic and alopecic well-demarcated lamellae of the stratum corneum, there are thickened skin lesions with scales and crusts.1,3,4 multiple cross and tangential sections of adult arthropod parasites measuring up to 1 mm in Transmission occurs through contact while diameter. They are round to oval, have a chitinous arthrospores may survive in the environment for exoskeleton with occasional spines, striated more than a year. Dermatophytes colonize the musculature and jointed appendages (scab mites). superficial dermis and hair follicles and they are adapted to digesting keratin.4,5 Histologically, Within dilated hair follicles and around free hair dermatophytes are more easily detectable using shafts in epidermal crusts are numerous 2-3 µm PAS method or Grocott stain. Septated hyphae are sized basophilic arthrospores and hyphae with detectable between the keratin of the stratum thin parallel walls and indistinct branching and corneum and within the hair shafts. There is 2 WSC 2014-2015 and marked dermal edema. In chronic cases, hyperplasia of the epidermis can be observed.1 Mites could be identified microscopically within skin scrapings or biopsies, but not with certainty.7 Sarcoptic mange is a differential diagnosis for the lesions in the present case. However, in the present case, the mites are detectable on the surface and between superficial keratin lamellae whereas Sarcoptes mites dig deeper. On the other hand there were no burrows filled with eggs and/ or larvae within the layers of the epidermis, which are typical for Sarcoptes but not seen in Psoroptes infestation.1 In the present case, a combined infection with 1-4. Haired skin, calf: Cross-sections of several arthropod parasties dermatophytes and mites occurred. The nutritional (consistent with mites) are present superficially to adjacent, less affected skin. Unfortunately, it is not possible to speciate the mite in tissue stage and concurrent debilitating diseases may section. (Photo courtesy of: Institut fuer Veterinaer-Pathologie, Justus- Liebig-Universitaet Giessen, Frankfurter Str. 96, 35392 Giessen, have influenced the development of both Germany http://www.uni-giessen.de/cms/fbz/fb10/institute_klinikum/ infections. Both diseases, mange and institute/pathologie) (Grocott, 400X) dermatophytosis, are differentials for each other, and it has to be considered, that dermatophytosis regularly a mild acanthosis and hyperkeratosis. 1 is a zoonotic disease. In contrast to Sarcoptes Inflammatory changes are often mild. mites Psoroptes mites are believed to be non- Vaccination is effective for prophylaxis and pathogenic for humans.1 treatment of bovine ringworm.6 JPC Diagnosis: Haired skin: Hyperplasia, Scab mites cause a highly pruritic dermatitis and epidermal, diffuse, moderate, with diffuse psoroptic mange is like demodicosis of high hyperkeratosis, serocellular crusts and numerous economic importance in bovine species. In some 1,3 intrafollicular dermatophyte arthrospores, hyphae, countries it is a reportable disease. Psoroptes and rare extraepidermal adult mites and eggs. ovis is the assumed species of mites responsible for psoroptic mange in cattle.8 Mites can survive Conference Comment: Conference participants for about 7-12 weeks outside the host. debated whether the rare mites observed in this Transmission results directly by contact or case were associated with any of the identified indirectly by vectors (e.g. bedding, contaminated lesions. As noted by the contributor, they are objects like feed fences or cow brushes). located superficially, sometimes exterior to the Psoroptes mites complete their life cycle on the stratum corneum, are at a distance from the crust skin. In contrast to Sarcoptes sp., they do not formation, and no burrows or larvae are present in invade the epidermis.7 the slides examined. We eventually elected to include the presence of mites within one diagnosis Lesions in cattle can be detected at the skin of the which implies their association with the cutaneous head, neck, back, inguinal and sacral areas and lesion, however, we cannot definitively prove may become generalized. They are characterized their causality. by alopecia, crusts, scales and exudation. Due to severe pruritus, excoriations and secondary Dermatophytosis is more common in young bacterial infections may blur the picture. In more animals and often associated with severe cases the skin shows increased thickness immunosuppression, which is supported in this with diffuse alopecia and deep folds.1,3,7 case by the simultaneous symptoms of respiratory disease and oral ulcers. Notably, other than the In accordance with the clinical symptoms, neutrophils within the crusts, there is minimal histologically there is superficial perivascular inflammation present despite the fungal dermatitis with eosinophils, lymphocytes, proliferation within nearly every hair shaft. macrophages and mast cells. Due to an assumed Avoiding immune detection and subsequent hypersensitivity reaction there is often spongiosis 3 WSC 2014-2015 provocation of an inflammatory response is instrumental to survival for these pathogens. The arthrospores are always along the periphery of the hair while hyphae are confined within the hair shaft.3 The organisms never penetrate Adamson’s fringe into the mitotic region of the follicle, and fungal growth is terminated along with growth of the hair. Dead telogen hairs, known as “club hairs”, are resistant to infection. Resolution of clinical signs typically occurs spontaneously within a few months.3 This is in contrast to other fungal infections which invade the subcutaneous tissue, incite a tremendous inflammatory response, and often necessitate surgical excision such as pseudomycetomas, phaeohyphomycosis and sporotrichosis.2 Contributing Institution: Institut fuer Veterinaer-Pathologie, Justus-Liebig-Universitaet Giessen, Frankfurter Str. 96, 35392 Giessen, Germany, http://www.uni-giessen.de/cms/fbz/ fb10/institute_klinikum/institute/pathologie References: 1. Ginn PE, Mansell JEKL, Rakich PM. Skin and appendages. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. 5th ed. Vol 1. Philadelphia, PA: Elsevier Limited; 2007:553-781. 2. Hargis AM, Ginn PE. The integument. In: Zachary JF, McGavin MD, eds. Pathologic Basis of Veterinary Disease. 5th ed. St. Louis, MO: Elsevier Mosby; 2012:1038-1039. 3. Scott DW. Large Animal Dermatology. Philadelphia, PA: WB Saunders Company; 1988:174-182. 4. Chermette R, Ferreiro L, Guillot J. Dermatophytoses in animals. Mycopathologia. 2008;166(5-6):385-405. 5. Bond R. Superficial veterinary mycoses. Clin Dermatol. 2010;28(2):226-236. 6. Lund A, Deboer DJ. Immunoprophylaxis of dermatophytosis in animals. Mycopathologia. 2008;166(5-6):407-424. 7. Rommel M, Eckert J, Kutzer E, Körting W, Schnieder T. Veterinärmedizinische Parasitologie. 5th ed. Berlin: Parey; 2000. 8. Bates PG. Inter- and intra-specific variation within the genus Psoroptes (Acari: Psoroptidae). Vet Parasitol. 1999;83(3-4):201-217. 4 WSC 2014-2015 CASE II: 05-2655A/B (JPC 3139939).
Load more

Recommended publications
  • General Pathomorpholog.Pdf
    Ukrаiniаn Medicаl Stomаtologicаl Аcаdemy THE DEPАRTАMENT OF PАTHOLOGICАL АNАTOMY WITH SECTIONSL COURSE MАNUАL for the foreign students GENERАL PАTHOMORPHOLOGY Poltаvа-2020 УДК:616-091(075.8) ББК:52.5я73 COMPILERS: PROFESSOR I. STАRCHENKO ASSOCIATIVE PROFESSOR O. PRYLUTSKYI АSSISTАNT A. ZADVORNOVA ASSISTANT D. NIKOLENKO Рекомендовано Вченою радою Української медичної стоматологічної академії як навчальний посібник для іноземних студентів – здобувачів вищої освіти ступеня магістра, які навчаються за спеціальністю 221 «Стоматологія» у закладах вищої освіти МОЗ України (протокол №8 від 11.03.2020р) Reviewers Romanuk A. - MD, Professor, Head of the Department of Pathological Anatomy, Sumy State University. Sitnikova V. - MD, Professor of Department of Normal and Pathological Clinical Anatomy Odessa National Medical University. Yeroshenko G. - MD, Professor, Department of Histology, Cytology and Embryology Ukrainian Medical Dental Academy. A teaching manual in English, developed at the Department of Pathological Anatomy with a section course UMSA by Professor Starchenko II, Associative Professor Prylutsky OK, Assistant Zadvornova AP, Assistant Nikolenko DE. The manual presents the content and basic questions of the topic, practical skills in sufficient volume for each class to be mastered by students, algorithms for describing macro- and micropreparations, situational tasks. The formulation of tests, their number and variable level of difficulty, sufficient volume for each topic allows to recommend them as preparation for students to take the licensed integrated exam "STEP-1". 2 Contents p. 1 Introduction to pathomorphology. Subject matter and tasks of 5 pathomorphology. Main stages of development of pathomorphology. Methods of pathanatomical diagnostics. Methods of pathomorphological research. 2 Morphological changes of cells as response to stressor and toxic damage 8 (parenchimatouse / intracellular dystrophies).
    [Show full text]
  • 'Spongiosis' Dermatitis With
    Spongiosis Spongiosis and Spongiotic • What is ‘spongiosis’? – Intra-epidermal and Dermatitis intercellular edema • Widening of intercellular spaces between keratinocytes • Elongation of G.Peter Sarantopoulos, MD intercellular bridges UCLA Medical Center Spongiosis vs. Spongiotic Spongiosis Dermatitis • ‘Spongiosis’ as a histologic concept (not a • Not everything ‘spongiotic’ is a diagnosis!) spongiotic dermatitis – Intra-epidermal edema accompanies many (if not all) inflammatory skin diseases to some degree • So-called ‘patterns of spongiosis’ • Important to distinguish spongiosis as… – Neutrophilic – The predominant histologic finding – Eosinophilic – A non-specific feature of other inflammatory – Follicular dermatoses (e.g. lichenoid/interface, vasculopathic, – Miliarial psoriasiform, etc) – Sometimes, there is overlap Dermatitis with ‘Spongiosis’ Dermatitis with ‘Spongiosis’ * Neutrophilic: Eosinophilic: Miliarial: Neutrophilic: Eosinophilic: Miliarial: Pustular psoriasis Pemphigus (precursor) M. Crystallina Pustular psoriasis Pemphigus (precursor) M. Crystallina Reiter’s syndrome Pemphigus vegetans M. Rubra Reiter’s syndrome Pemphigus vegetans M. Rubra IgA Pemphigus Bullous pemphigoid M. profunda IgA Pemphigus Bullous pemphigoid M. profunda Pemphigus herpetiformis Cicatricial pemphigoid Pemphigus herpetiformis Cicatricial pemphigoid Infantile acropustulosis Pemphigoid (herpes) Infantile acropustulosis Pemphigoid (herpes) AGEP gestationis Follicular: AGEP gestationis Follicular: Palmoplantar pustulosis Idiopathic eosinophilic Infundibulofolliculitis
    [Show full text]
  • Fundamentals of Dermatology Describing Rashes and Lesions
    Dermatology for the Non-Dermatologist May 30 – June 3, 2018 - 1 - Fundamentals of Dermatology Describing Rashes and Lesions History remains ESSENTIAL to establish diagnosis – duration, treatments, prior history of skin conditions, drug use, systemic illness, etc., etc. Historical characteristics of lesions and rashes are also key elements of the description. Painful vs. painless? Pruritic? Burning sensation? Key descriptive elements – 1- definition and morphology of the lesion, 2- location and the extent of the disease. DEFINITIONS: Atrophy: Thinning of the epidermis and/or dermis causing a shiny appearance or fine wrinkling and/or depression of the skin (common causes: steroids, sudden weight gain, “stretch marks”) Bulla: Circumscribed superficial collection of fluid below or within the epidermis > 5mm (if <5mm vesicle), may be formed by the coalescence of vesicles (blister) Burrow: A linear, “threadlike” elevation of the skin, typically a few millimeters long. (scabies) Comedo: A plugged sebaceous follicle, such as closed (whitehead) & open comedones (blackhead) in acne Crust: Dried residue of serum, blood or pus (scab) Cyst: A circumscribed, usually slightly compressible, round, walled lesion, below the epidermis, may be filled with fluid or semi-solid material (sebaceous cyst, cystic acne) Dermatitis: nonspecific term for inflammation of the skin (many possible causes); may be a specific condition, e.g. atopic dermatitis Eczema: a generic term for acute or chronic inflammatory conditions of the skin. Typically appears erythematous,
    [Show full text]
  • 2016 Essentials of Dermatopathology Slide Library Handout Book
    2016 Essentials of Dermatopathology Slide Library Handout Book April 8-10, 2016 JW Marriott Houston Downtown Houston, TX USA CASE #01 -- SLIDE #01 Diagnosis: Nodular fasciitis Case Summary: 12 year old male with a rapidly growing temple mass. Present for 4 weeks. Nodular fasciitis is a self-limited pseudosarcomatous proliferation that may cause clinical alarm due to its rapid growth. It is most common in young adults but occurs across a wide age range. This lesion is typically 3-5 cm and composed of bland fibroblasts and myofibroblasts without significant cytologic atypia arranged in a loose storiform pattern with areas of extravasated red blood cells. Mitoses may be numerous, but atypical mitotic figures are absent. Nodular fasciitis is a benign process, and recurrence is very rare (1%). Recent work has shown that the MYH9-USP6 gene fusion is present in approximately 90% of cases, and molecular techniques to show USP6 gene rearrangement may be a helpful ancillary tool in difficult cases or on small biopsy samples. Weiss SW, Goldblum JR. Enzinger and Weiss’s Soft Tissue Tumors, 5th edition. Mosby Elsevier. 2008. Erickson-Johnson MR, Chou MM, Evers BR, Roth CW, Seys AR, Jin L, Ye Y, Lau AW, Wang X, Oliveira AM. Nodular fasciitis: a novel model of transient neoplasia induced by MYH9-USP6 gene fusion. Lab Invest. 2011 Oct;91(10):1427-33. Amary MF, Ye H, Berisha F, Tirabosco R, Presneau N, Flanagan AM. Detection of USP6 gene rearrangement in nodular fasciitis: an important diagnostic tool. Virchows Arch. 2013 Jul;463(1):97-8. CONTRIBUTED BY KAREN FRITCHIE, MD 1 CASE #02 -- SLIDE #02 Diagnosis: Cellular fibrous histiocytoma Case Summary: 12 year old female with wrist mass.
    [Show full text]
  • Lumps & Bumps: Approach to Common Dermatologic Neoplasms
    Case-Based Approach to Common Dermatologic Neoplasms Patrick Retterbush, MD, FAAD Mohs Surgery & Dermatologic Oncology Associate Member of the American College of Mohs Surgery Private Practice: Lockman Dermatology January 27th 2018 Disclosure of Relevant Financial Relationships • I do not have any relevant financial relationships, commercial interests, and/or conflicts of interest regarding the content of this presentation. Goals/Objectives • Recognize common benign growths • Recognize common malignant growths • Useful clues & examination for evaluating melanocytic nevi and when to be concerned for melanoma/atypical moles • How to perform a basic skin biopsy and which method/type to choose • Basic treatment/when to refer Key Questions & Physical Examination Findings for a Growth History Physical Examination • How long has the lesion been • Describing a growth present? – flat or raised? • flat – macule (<1cm) or patch (>1cm) – years, months, weeks • raised – papule (<1cm) or plaque (>1cm) – nodule if deep (majority of lesion in • Has it changed? dermis/SQ) – Size – secondary descriptive features • scaly (hyperkeratosis, retention of strateum – Shape corneum) – Color • crusty (dried serum, blood, or pus on surface) • eroded or ulcerated (partial vs. full thickness – Symptoms – pain, bleeding, itch? epidermal loss) – Over what time frame? • color (skin colored, red, pigmented, pearly) • feel (hard or soft, mobile or fixed) • PMH: • size: i.e. 6 x 4mm – prior skin cancers • Look at the rest of the skin/region of skin • SCC/BCCs vs. melanoma
    [Show full text]
  • SKIN VERSUS PEMPHIGUS FOLIACEUS and the AUTOIMMUNE GANG Lara Luke, BS, RVT, Dermatology, Purdue Veterinary Teaching Hospital
    VETERINARY NURSING EDUCATION SKIN VERSUS PEMPHIGUS FOLIACEUS AND THE AUTOIMMUNE GANG Lara Luke, BS, RVT, Dermatology, Purdue Veterinary Teaching Hospital This program was reviewed and approved by the AAVSB Learning Objective: After reading this article, the participant will be able to dis- RACE program for 1 hour of continuing education in jurisdictions which recognize AAVSB RACE approval. cuss and compare autoimmune diseases that have dermatological afects, includ- Please contact the AAVSB RACE program if you have any ing Pemphigus Foliaceus (PF), Pemphigus Erythematosus (PE), Discoid Lupus comments/concerns regarding this program’s validity or relevancy to the veterinary profession. Erythematosus (DLE), Systemic Lupus Erythematosus (SLE). In addition, the reader will become familiar with diagnostic and treatment techniques. FUNCTION OF THE SKIN Te skin is the largest organ of the body. Along with sensory function, it provides a barrier between the inside and outside world. Te epidermis is composed of the following fve layers: stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum. Te stratum lucidum is found only on the nasal planum and footpads. When the cells of the epidermis are disrupted by systemic disease, the barrier is also disrupted. Clinical signs of skin disease will bring the patient into the veterinarian’s ofce for diagnosis. 32 THE NAVTA JOURNAL | NAVTA.NET VETERINARY NURSING EDUCATION THE PEMPHIGUS COMPLEX article.3 Histologically it shares characteris- Pemphigus Foliaceus tics of both PF and DLE.1 This classifcation PF is an immune mediated pustular disor- is still considered controversial and PE may der included in a group of diseases known just be a localized variant of PF.1 as the pemphigus complex.
    [Show full text]
  • WSC 13-14 Conf 13 Layout
    Joint Pathology Center Veterinary Pathology Services WEDNESDAY SLIDE CONFERENCE 2013-2014 Conference 13 29 January 2014 CASE I: AVC C3670-13 (JPC 4032590). for 10-12 days and then stopped eating. Most recently, the dog developed diarrhea, non- Signalment: 10-year-old male castrated Shetland regenerative anemia and glucosuria. An Sheepdog (Canis familiaris). abdominal ultrasound revealed a severe and diffuse mottled appearance of the liver with a History: This dog was diagnosed with honeycomb pattern. Liver aspirates were taken dermatomyositis as a puppy; it had footpad for cytology assessment and the footpads were lesions characterized by hyperkeratosis, erythema, biopsied. The animal continued to deteriorate and scaling and crusting. The dog was treated first was euthanized at the owner’s request. The with novalexin and then prednisone; he did well veterinarian obtained permission to perform a postmortem examination. The liver was diffusely nodular; the rest of the abdominal viscera were unremarkable. Samples of liver and skin were submitted for histopathology. Gross Pathology: Two punch skin biopsies (0.7 cm in greatest diameter) with ulcerated surfaces and two fragments of liver (3.5 cm and 2.5 cm in their largest dimension) were submitted for histopathology. The liver samples had a nodular, irregular, capsular surface. Laboratory Results: Parameter Value Reference Interval Albumin 23 G/L 24-55 1-1. Haired skin, dog: This section of skin is covered by a thick parakeratotic serocellular crust (extending down into hair follicles), ALP 1632 U/L 20-150 with marked acanthosis and hyperplasia of basal epithelium. (HE 0.63X) 1 WSC 2013-2014 ALT 442 U/L 10-118 Glucose 9.2 mmol/L 3.3-6.1 WBC 19.1 x 103/ 6.0-17.0 mm3 segmented 94% lymphocytes 3% monocytes 2% bands 1% RBC 4.12 x 106/ 5.50-8.50 mm3 urine glucose 3+ 1-2.
    [Show full text]
  • Description, Definition and Diagnosis of Common Skin Rashes
    Description, Definition and Diagnosis of Common Skin Rashes Daniel Zelac, MD Scripps Clinic Acknowledgements . Conflicts of Interest – None . Many of the photographs and diagrams contained in this talk can be referenced in Clinical Dermatology, 5th Edition By Thomas P. Habif, MD . Please do not further duplicate these images . (referenced in talk as “Habif 5th”) What is a rash? . Definition by Webster’s – an eruption of the body . Definition - The popular term for a group of spots or red, inflamed skin that is usually a symptom of an underlying condition or disorder. Often temporary, a rash is only rarely a sign of a serious problem. The Free Dictionary by Farlex . http://medical-dictionary.thefreedictionary.com/Rashes Can we make the diagnosis based solely on one finding? Finding the clues to diagnosis Lesion Types . Primary Lesion - Typically the earliest representative physical finding related to a disease or a condition . Secondary Lesion – A physical finding that develops during the evolution of a disease or condition and can often be affected by the interaction with the patient or others Distribution . Symmetry . Linear . Sun-exposed . Geographic . Accessible . Serpiginous . Palmar/Plantar . Annular . Inguinal/Intertriginous . Hair-bearing . Mucosal . Dermatome Primary Lesions . Macule - Flat circumscribed skin demonstrating a variation in color from surrounding skin <1cm diameter . Patch – Large macule > 1 cm diameter Primary Lesions . Papule – Solid palpable lesion < 0.5cm diameter . Plaque- a broad papule demonstrating elevation from the surrounding skin >0.5 cm diameter, appear relatively flat with no, or limited deep component . Nodule- a larger palpable solid elevation >0.5 cm diameter, often with a deep component Primary Lesions .
    [Show full text]
  • Ministry of Health of Ukraine Ukrainian Medical Stomatolgical Academy
    Ministry of Health of Ukraine Ukrainian Medical Stomatolgical Academy Methodical Instructions for independent work of students during the training for the practical studies Academic discipline Surgical stomatology Моdule № 3 The topic of the stadies Epithelial tumors of the soft tissues. Tumor-like № 1 formations of the soft tissues: atheroma, rhinophyma, keratoacanthoma, keratolytic papilloma (skin horn). Clinical manifestations, differential diagnosis and treatment. Course IV Faculty Foreign Students Training, Stomatological Poltava – 2020 1 1. Relevance of the topic: The Skin Cancer Foundation recommends the monthly head-to-toe self examination of the skin, so that one can find any new or changing lesions that might be cancerous or precancerous. Skin cancers found and removed early are almost always curable. Learn about the warnings signs of skin cancer and what to look for during a self examination. If you spot anything suspicious, see a doctor. Performed regularly, self-examination can alert you to changes in your skin and aid in the early detection of skin cancer. It should be done often enough to become a habit, but not so often as to feel like a bother. For most people, once a month is ideal, but ask your doctor if you should do more frequent checks. You may find it helpful to have a doctor do a full-body exam first, to assure you that any existing spots, freckles, or moles are normal or treat any that may not be. After the first few times, self-examination should take no more than 10 minutes – a small investment in what could be a life-saving procedure.
    [Show full text]
  • Depressed Shiny Scars and Crusted Erosions
    DERMATOPATHOLOGY DIAGNOSIS Depressed Shiny Scars and Crusted Erosions Christina Dai, MD; Alison E. Seline, MD; Olayemi Sokumbi, MD Eligible for 1 MOC SA Credit From the ABD This Dermatopathology Diagnosis in our print edition is eligible for 1 self-assessment credit for Maintenance of Certification from the American Board of Dermatology (ABD). After completing this activity, diplomates can visit the ABD website (http://www.abderm.org) to self-report the credits under the activity title “Cutis Dermatopathology Diagnosis.” You may report the credit after each activity is completed or after accumulating multiple credits. A 9-year-old girl presentedcopy with unexplained burn- ing pain on the face, hands, and feet of 3 years’ duration. Physical examination showed depressed shiny scars and crusted erosions on the dorsal aspect of the nose, arms, hands, and fingers. A 3-mm punch biopsy specimen was obtainednot from the right hand. THE BEST DIAGNOSIS IS: a. erythropoietic protoporphyria H&E, original magnification ×100 (inset, original magnification ×400). b. juvenile colloid milium c. lichen amyloidosis Dod. lipoid proteinosis e. porphyria cutanea tarda PLEASE TURN TO PAGE 62 FOR THE DIAGNOSIS CUTIS Drs. Dai and Sokumbi are from Mayo Clinic Florida, Jacksonville. Dr. Seline is from the Department of Dermatology, Medical College of Wisconsin, Milwaukee. The authors report no conflict of interest. Correspondence: Christina Dai, MD, 4500 San Pablo Rd S, Jacksonville, FL 32224 ([email protected]). doi:10.12788/cutis.0027 WWW.MDEDGE.COM/DERMATOLOGY VOL. 106 NO. 2 I AUGUST 2020 61 Copyright Cutis 2020. No part of this publication may be reproduced, stored, or transmitted without the prior written permission of the Publisher.
    [Show full text]
  • Neglected Tropical Diseases Through Changes on the Skin
    RECOGNIZING NEGLECTED TROPICAL DISEASES THROUGH CHANGES ON THE SKIN The skin of a patient is the first and most visible structure of the body that any health-care worker encounters during the course of an examination. To the patient, it is also highly visible, and any disease that affects it is noticeable and will have an impact on personal and social well-being. The skin is therefore an important entry point for both diagnosis and management. Many diseases of humans are associated with changes to the skin, ranging from symptoms such as itching to changes in colour, feel and appearance. The major neglected tropical diseases (NTDs) frequently produce such changes in the skin, re-enforcing the feelings of isolation and stigmatization experienced by patients affected by these diseases. Indeed, these are often the first signs that patients will notice, even before changes in internal organs or other systems occur. The following NTDs all have prominent skin changes at some stage in their evolution. Buruli ulcer Cutaneous leishmaniasis Post kala-azar dermal leishmaniasis Leprosy Lymphatic filariasis Mycetoma Onchocerciasis Podoconiosis Scabies Yaws (endemic treponematosis) Buruli ulcer Cutaneous leishmaniasis Post kala-azar dermal leishmaniasis Leprosy Lymphatic filariasis Mycetoma Onchocerciasis Podoconiosis Scabies Yaws (endemic treponematosis) Buruli ulcer Cutaneous leishmaniasis Post kala-azar dermal leishmaniasis Leprosy Lymphatic filariasis Mycetoma OnchocerciasisPodoconiosis Scabies Yaws (endemic treponematosis) Buruli ulcer Cutaneous leishmaniasis Post kala-azar dermal leishmaniasis Leprosy Lymphatic filariasis Mycetoma Onchocerciasis Podoconiosis Scabies Yaws (endemic treponematosis) This training guide explains how to identify the signs and symptoms of neglected tropical diseases of the skin through their visible characteristics.
    [Show full text]
  • Discoid Lupus Erythematosus Presenting As Upper Eyelid Edema and Erythema
    CASE REPORT Discoid Lupus Erythematosus Presenting as Upper Eyelid Edema and Erythema Abbas Darjani1, Rana Rafiei1, Alireza Mesbah1, Razieh Golmohammadi1, Behnam Rafiee2, and Mehriar Movaseghi1 1 Department of Dermatology, Skin Research Center, Guilan University of Medical Sciences, Rasht, Iran 2 Department of Pathology, NYU Winthrop Hospital, New York, USA Received: 15 Mar. 2016; Accepted: 14 Oct. 2016 Abstract: Discoid Lupus Erythematosus (DLE) is an autoimmune disorder that usually occurs on sun exposed areas of head and neck. Infrequently it could be presented by palpebral involvement and rarely unilateral upper eye lid edema and erythema have been reported as the sole manifestation of DLE. We describe a 38-year-old woman with chronic left upper eye lid edema and erythema from one year ago which was induced by steroid injection for left eyebrow alopecia. Histopathologic and direct immunofluorescent studies were made on palpebral skin tissue and confirmed DLE diagnosis. Antinuclear antibody (ANA) titer was 1/160 with speckled pattern. She was treated by oral hydroxychloroquine (400 mg daily) with moderate improvement after three months. We should think about DLE in cases with chronic upper eye lid edema and erythema. The aim of this case report is to emphasize that ophthalmologist and dermatologists should be aware of different presentations of DLE in the periorbital area to prevent misdiagnosis. © 2017 Tehran University of Medical Sciences. All rights reserved. Acta Med Iran 2017;55(7):474-476. Keywords: Discoid lupus erythematosus; Eyelid; Edema; Erythema Introduction triamcinolone injection one week before upper eyelid edema, and no other trauma was noted. Eyebrow DLE is a chronic autoimmune disorder which alopecia was improved three weeks after steroid typically presents by circumscribed, scaly, erythematous injection, but eye lid edema continued and became lesions which involve sun exposed areas especially face, erythematous after six months.
    [Show full text]