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Myocardial Ischemia Reperfusion Injury Is Alleviated by Curcumin
Liao et al. Stem Cell Research & Therapy (2021) 12:89 https://doi.org/10.1186/s13287-020-02101-y RESEARCH Open Access Myocardial ischemia reperfusion injury is alleviated by curcumin-peptide hydrogel via upregulating autophagy and protecting mitochondrial function Chi-Lin Liao1†, Yang Liu2†, Meng-Zhao Huang1, Hua-Yong Liu1, Zi-Liang Ye3 and Qiang Su3* Abstract Background: Ischemia-reperfusion injury (IRI) is an important factor limiting the success of cardiac reperfusion therapy. Curcumin has a significant cardioprotective effect against IRI, can inhibit ventricular remodeling induced by pressure load or MI, and improve cardiac function. However, the poor water solubility and low bioavailability of curcumin restrict its clinical application. Methods: In this study, we prepared and evaluated a curcumin-hydrogel (cur-hydrogel) to reduce cardiomyocyte apoptosis and reactive oxygen species formation induced by hypoxia-reoxygenation injury, promote autophagy, and reduce mitochondrial damage by maintaining the phosphorylation of Cx43. Results: Meanwhile, cur-hydrogel can restore cardiac function, inhibit myocardial collagen deposition and apoptosis, and activate JAK2/STAT3 pathway to alleviate myocardial ischemia-reperfusion injury in rats. Conclusions: The purpose of this study is to elucidate the protective effects of cur-hydrogel on myocardial ischemia-reperfusion injury by regulating apoptosis, autophagy, and mitochondrial injury in vitro and in vivo, which lays a new theoretical and experimental foundation for the prevention and reduction -
Research on the Tourism Space Structure in Lingui District of Guilin Based on the Development and Utilization of Landscape Resources
E3S Web of Conferences 53, 03061 (2018) https://doi.org/10.1051/e3sconf/20185303061 ICAEER 2018 Research on the Tourism Space Structure in Lingui District of Guilin Based on the Development and Utilization of Landscape Resources Zhengmin Wen1,2,*,Jie Shi2,Shuangbao Qian2 and Qing Xu2 1Architecture College, Xi'an University of Architecture and Technology, Xi'an, 710055,Cnina; 2School of Civil Engineering and Architecture, Guilin University of Technology, Guilin, 541004, China Abstract: The 257 scenic spots in Lingui covered 5 main categories, 14 sub-categories and 26 basic types, in which there were 33 natural scenic spots and 224 humanistic scenic spots, featured by rich resources stock, humanistic landscape resources-based, and significant space agglomeration; the quality levels are 11 high-quality scenic spots that most of them have been developed, 57 good scenic spots and 189 ordinary scenic spots that have big development potential; of the 36 scenic spots developed so far, 7 are natural, and 29 are humanistic(22 of them have been oriented by cultural relic protection sites); from initial scattered-point to intensive scattered-point to point-axis period, they showed stepped and multi-center structure situation. We found that: 1) five levels of growth pole have been formed; 2) The influence mechanism of development on tourism space is: the theme park is the greatest, the natural landscape resources is secondary and the cultural landscape resources is the least, the former-residence -type cultural relics protection sites and traditional villages have a certain influence, and the influence of high-level landscape resources is big in general. -
2016 Annual Report.PDF
HAITONG SECURITIES CO., LTD. 海通證券股份有限公司 Annual Report 2016 2016 Annual Report 年度報告 CONTENTS Section I Definition and Important Risk Warnings 3 Section II Company Profile and Key Financial Indicators 7 Section III Summary of the Company’s Business 23 Section IV Report of the Board of Directors 28 Section V Significant Events 62 Section VI Changes in Ordinary Share and Particulars about Shareholders 91 Section VII Preferred Shares 100 Section VIII Particulars about Directors, Supervisors, Senior Management and Employees 101 Section IX Corporate Governance 149 Section X Corporate Bonds 184 Section XI Financial Report 193 Section XII Documents Available for Inspection 194 Section XIII Information Disclosure of Securities Company 195 IMPORTANT NOTICE The Board, the Supervisory Committee, Directors, Supervisors and senior management of the Company represent and warrant that this annual report (this “Report”) is true, accurate and complete and does not contain any false records, misleading statements or material omission and jointly and severally take full legal responsibility as to the contents herein. This Report was reviewed and passed at the twenty-third meeting of the sixth session of the Board. The number of Directors to attend the Board meeting should be 13 and the number of Directors having actually attended the Board meeting was 11. Director Li Guangrong, was unable to attend the Board meeting in person due to business travel, and had appointed Director Zhang Ming to vote on his behalf. Director Feng Lun was unable to attend the Board meeting in person due to business travel and had appointed Director Xiao Suining to vote on his behalf. -
A Legacy in Chinese Education History, Or a Solution for Modern Undergraduates in China?
Journal of Education and Learning; Vol. 9, No. 6; 2020 ISSN 1927-5250 E-ISSN 1927-5269 Published by Canadian Center of Science and Education Chinese Shuyuan: A Legacy in Chinese Education History, or a Solution for Modern Undergraduates in China? Zhen Zeng1 1 School of Foreign Studies, Guangxi Normal University, Guilin, Guangxi, China Correspondence: Zhen Zeng, 82 Liuhe Road, Qixing District, Guilin, Guangxi, Postal Code: 541004, China. E-mail: [email protected] Received: September 28, 2020 Accepted: November 19, 2020 Online Published: November 26, 2020 doi:10.5539/jel.v9n6p173 URL: https://doi.org/10.5539/jel.v9n6p173 Abstract The paper looked into concepts claimed to be essence of Chinese residential college, an on-going institution presumed to be a solution towards undergraduates’ issues in some pioneer universities in China. It’s analyzed that Chinese residential college today in China is not a Shuyuan that was ever striving as a unique education mode in ancient China, even if it’s named after Shuyuan in Chinese, concerning on its nature, function and goal, while it’s not a conventional residential college in English speaking countries neither. By investigation and comparison of its origin, function and features among Shuyuan and Chinese residential college, the spirit of development of a human with goodness and well-being through pursuit of knowledge and culture inherited and transmitted in Shuyuan is unearthed, which is supposed to be the resource of inspiration when the pioneer universities and educators designed and operate residential college on Chinese campus, though the effects couldn’t be accounted as appealing as what Shuyuan produced in ancient China. -
Evaluating Water Resource Accessibility in Southwest China
water Article Evaluating Water Resource Accessibility in Southwest China Tao Li 1,2, Sha Qiu 1,2, Shuxin Mao 3 , Rui Bao 1,2 and Hongbing Deng 1,* 1 State Key Laboratory of Urban and Regional Ecology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China 2 University of Chinese Academy of Sciences, Beijing 100049, China 3 School of Economics and Management, Shanxi University of Science & Technology, Xi’an 710021, China * Correspondence: [email protected]; Tel.: +86-010-6284-9112 Received: 18 July 2019; Accepted: 14 August 2019; Published: 16 August 2019 Abstract: The accessibility, quantity, and quality of water resources are the basic requirements for guaranteeing water resource security. Research into regional water resource accessibility will contribute to improving regional water resource security and effective water resource management. In this study, we used a water resource accessibility index model considering five spatial factors to evaluate the grid-scale water resource accessibility and constructed the spatial pattern of water resource accessibility in Southwest China. Then, we analyzed the coupling coordination degree between county-level water resource accessibility and eco-socio-economic water demand elements. The water resource accessibility showed obvious regional differences, and the overall trend gradually decreased from Southeast to Northwest. The coupling coordination degree between county-level water resource accessibility and eco-socio-economic water demand elements was between 0.26 and 0.84, and was relatively low overall, whereas the counties (districts) with high coordination, moderate coordination, low coordination, reluctant coordination, and incoordination accounted for 0.92%, 5.31%, 21.06%, 59.71%, and 13.00% of total counties (districts), respectively. -
Chronology of Mass Killings During the Chinese Cultural Revolution (1966-1976) Song Yongyi Thursday 25 August 2011
Chronology of Mass Killings during the Chinese Cultural Revolution (1966-1976) Song Yongyi Thursday 25 August 2011 Stable URL: http://www.massviolence.org/Article?id_article=551 PDF version: http://www.massviolence.org/PdfVersion?id_article=551 http://www.massviolence.org - ISSN 1961-9898 Chronology of Mass Killings during the Chinese Cultural Revolution (1966-1976) Chronology of Mass Killings during the Chinese Cultural Revolution (1966-1976) Song Yongyi The Chinese Cultural Revolution (1966-1976) was a historical tragedy launched by Mao Zedong and the Chinese Communist Party (CCP). It claimed the lives of several million people and inflicted cruel and inhuman treatments on hundreds of million people. However, 40 years after it ended, the total number of victims of the Cultural Revolution and especially the death toll of mass killings still remain a mystery both in China and overseas. For the Chinese communist government, it is a highly classified state secret, although they do maintain statistics for the so-called abnormal death numbers all over China. Nevertheless, the government, realizing that the totalitarian regime and the endless power struggles in the CCP Central Committee (CCP CC) were the root cause of the Cultural Revolution, has consistently discounted the significance of looking back and reflecting on this important period of Chinese history. They even forbid Chinese scholars from studying it independently and discourage overseas scholars from undertaking research on this subject in China. Owing to difficulties that scholars in and outside China encounter in accessing state secrets, the exact figure of the abnormal death has become a recurring debate in the field of China studies. -
Creative Research on Rural Tourism Products Based on TAIM Model – Take Xintian Village of Quanzhou County As an Example
E3S Web of Conferences 143, 01036 (2 020) https://doi.org/10.1051/e3sconf/20 2014301036 ARFEE 2019 Creative Research on Rural Tourism Products Based on TAIM Model – Take Xintian Village of Quanzhou County as an Example Ying Liu1,* , Rong Wang1 1College of Tourism & Landscape Architecture, Guilin University of Technology,Guilin ,541000, China Abstract: At present, the development of rural tourism in China is faced with the embarrassment of "small scale, flat resources" and the lack of creative planning methods, which leads to the serious problem of the simplification and homogeneity of rural tourism products. From the perspective of cultural creativity, this paper puts forward TAIM model of rural tourism product development, and takes "Guangxi district-level rural tourism poverty alleviation village" Xintian village of Quanzhou county as an example to make an empirical analysis of this model, in order to provide some inspiration for the development of rural tourism products in China. 1 Introduction integrate creative elements into the design of rural tourism products to design new tourism products with educational With the development of social economy and the increase and experiential characteristics [4]. With the advent of the of "small holidays", rural tourism has developed rapidly. era of deep experience, the development of rural tourism It is predicted through big data deduction that the number in China has encountered major problems of product of rural tourism visitors is expected to reach 3 billion in transformation and upgrading, especially the "plain 2025. Rural tourism in China enjoys a good momentum of resources" in the countryside. This requires more development, but also faces some problems. -
EIB-Funded Rare, High-Quality Timber Forest Sustainability Project Non
EIB-funded Rare, High-quality Timber Forest Sustainability Project Non-technical Summary of Environmental Impact Assessment State Forestry Administration December 2013 1 Contents 1、Source of contents ............................... Error! Bookmark not defined. 2、Background information ................................................................... 1 3、Project objectives ................................................................................ 1 4、Project description ............................................................................. 1 4.1 Project site ...................................................................................... 1 4.2 Scope of project .............................................................................. 2 4.3 Project lifecyle .............................................................................. 2 4.4 Alternatives .................................................................................... 3 5、 Factors affecting environment ...................................................... 3 5.1 Positive environmental impacts of the project ............................ 3 5.2 Without-project environment impacts ........................................ 3 5.3 Potential negative envrionmnetal impacts ..................................... 3 5.4 Negative impact mitigation measures ............................................ 4 6、 Environmental monitoring .............................................................. 5 6.1 Environmental monitoring during project implementation .......... -
Table of Codes for Each Court of Each Level
Table of Codes for Each Court of Each Level Corresponding Type Chinese Court Region Court Name Administrative Name Code Code Area Supreme People’s Court 最高人民法院 最高法 Higher People's Court of 北京市高级人民 Beijing 京 110000 1 Beijing Municipality 法院 Municipality No. 1 Intermediate People's 北京市第一中级 京 01 2 Court of Beijing Municipality 人民法院 Shijingshan Shijingshan District People’s 北京市石景山区 京 0107 110107 District of Beijing 1 Court of Beijing Municipality 人民法院 Municipality Haidian District of Haidian District People’s 北京市海淀区人 京 0108 110108 Beijing 1 Court of Beijing Municipality 民法院 Municipality Mentougou Mentougou District People’s 北京市门头沟区 京 0109 110109 District of Beijing 1 Court of Beijing Municipality 人民法院 Municipality Changping Changping District People’s 北京市昌平区人 京 0114 110114 District of Beijing 1 Court of Beijing Municipality 民法院 Municipality Yanqing County People’s 延庆县人民法院 京 0229 110229 Yanqing County 1 Court No. 2 Intermediate People's 北京市第二中级 京 02 2 Court of Beijing Municipality 人民法院 Dongcheng Dongcheng District People’s 北京市东城区人 京 0101 110101 District of Beijing 1 Court of Beijing Municipality 民法院 Municipality Xicheng District Xicheng District People’s 北京市西城区人 京 0102 110102 of Beijing 1 Court of Beijing Municipality 民法院 Municipality Fengtai District of Fengtai District People’s 北京市丰台区人 京 0106 110106 Beijing 1 Court of Beijing Municipality 民法院 Municipality 1 Fangshan District Fangshan District People’s 北京市房山区人 京 0111 110111 of Beijing 1 Court of Beijing Municipality 民法院 Municipality Daxing District of Daxing District People’s 北京市大兴区人 京 0115 -
Annual Report 2019
HAITONG SECURITIES CO., LTD. 海通證券股份有限公司 Annual Report 2019 2019 年度報告 2019 年度報告 Annual Report CONTENTS Section I DEFINITIONS AND MATERIAL RISK WARNINGS 4 Section II COMPANY PROFILE AND KEY FINANCIAL INDICATORS 8 Section III SUMMARY OF THE COMPANY’S BUSINESS 25 Section IV REPORT OF THE BOARD OF DIRECTORS 33 Section V SIGNIFICANT EVENTS 85 Section VI CHANGES IN ORDINARY SHARES AND PARTICULARS ABOUT SHAREHOLDERS 123 Section VII PREFERENCE SHARES 134 Section VIII DIRECTORS, SUPERVISORS, SENIOR MANAGEMENT AND EMPLOYEES 135 Section IX CORPORATE GOVERNANCE 191 Section X CORPORATE BONDS 233 Section XI FINANCIAL REPORT 242 Section XII DOCUMENTS AVAILABLE FOR INSPECTION 243 Section XIII INFORMATION DISCLOSURES OF SECURITIES COMPANY 244 IMPORTANT NOTICE The Board, the Supervisory Committee, Directors, Supervisors and senior management of the Company warrant the truthfulness, accuracy and completeness of contents of this annual report (the “Report”) and that there is no false representation, misleading statement contained herein or material omission from this Report, for which they will assume joint and several liabilities. This Report was considered and approved at the seventh meeting of the seventh session of the Board. All the Directors of the Company attended the Board meeting. None of the Directors or Supervisors has made any objection to this Report. Deloitte Touche Tohmatsu (Deloitte Touche Tohmatsu and Deloitte Touche Tohmatsu Certified Public Accountants LLP (Special General Partnership)) have audited the annual financial reports of the Company prepared in accordance with PRC GAAP and IFRS respectively, and issued a standard and unqualified audit report of the Company. All financial data in this Report are denominated in RMB unless otherwise indicated. -
Anisotropic Patterns of Liver Cancer Prevalence in Guangxi in Southwest China: Is Local Climate a Contributing Factor?
DOI:http://dx.doi.org/10.7314/APJCP.2015.16.8.3579 Anisotropic Patterns of Liver Cancer Prevalence in Guangxi in Southwest China: Is Local Climate a Contributing Factor? RESEARCH ARTICLE Anisotropic Patterns of Liver Cancer Prevalence in Guangxi in Southwest China: Is Local Climate a Contributing Factor? Wei Deng1&, Long Long2&*, Xian-Yan Tang3, Tian-Ren Huang1, Ji-Lin Li1, Min- Hua Rong1, Ke-Zhi Li1, Hai-Zhou Liu1 Abstract Geographic information system (GIS) technology has useful applications for epidemiology, enabling the detection of spatial patterns of disease dispersion and locating geographic areas at increased risk. In this study, we applied GIS technology to characterize the spatial pattern of mortality due to liver cancer in the autonomous region of Guangxi Zhuang in southwest China. A database with liver cancer mortality data for 1971-1973, 1990-1992, and 2004-2005, including geographic locations and climate conditions, was constructed, and the appropriate associations were investigated. It was found that the regions with the highest mortality rates were central Guangxi with Guigang City at the center, and southwest Guangxi centered in Fusui County. Regions with the lowest mortality rates were eastern Guangxi with Pingnan County at the center, and northern Guangxi centered in Sanjiang and Rongshui counties. Regarding climate conditions, in the 1990s the mortality rate of liver cancer positively correlated with average temperature and average minimum temperature, and negatively correlated with average precipitation. In 2004 through 2005, mortality due to liver cancer positively correlated with the average minimum temperature. Regions of high mortality had lower average humidity and higher average barometric pressure than did regions of low mortality. -
Due Diligence Report PRC: Guangxi Regional Cooperation And
Due Diligence Report Project Number: 50050-004 July 2017 PRC: Guangxi Regional Cooperation and Integration Promotion Investment Program – Tranche 2 Prepared by the Guangxi Zhuang Autonomous Region Government for the Asian Development Bank. This due diligence report is a document of the borrower. The views expressed herein do not necessarily represent those of ADB's Board of Directors, Management, or staff, and may be preliminary in nature. Your attention is directed to the “terms of use” section on ADB’s website. In preparing any country program or strategy, financing any project, or by making any designation of or reference to a particular territory or geographic area in this document, the Asian Development Bank does not intend to make any judgments as to the legal or other status of any territory or area. PRC-ASEAN SME Synergy Innovative Development Project (New Campus Expansion Project of Guilin University of Aerospace Technology) Resettlement Due Diligence Report Guilin University of Aerospace Technology June, 2017 Table of Contents 1. INTRODUCTION ................................................................................................................ 1 1.1 PROJECT BACKGROUND ..................................................................................................... 1 1.2 LAND ACQUISITION AND RESETTLEMENT IMPACTS ................................................................ 1 1.3 THE OBJECTIVES AND METHODS OF DATA COLLECTION FOR RESETTLEMENT DUE DILIGENCE REVIEW ..................................................................................................................................