bioRxiv preprint doi: https://doi.org/10.1101/166306; this version posted January 4, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. 1 Title: Environmental anchoring of grid-like representations minimizes 2 spatial uncertainty during navigation 3 4 Authors: Tobias Navarro Schröder*1,2, Benjamin W. Towse3,4, Matthias Nau1, Neil 5 Burgess3,4, Caswell Barry5, Christian F. Doeller1,6 6 7 Affiliation: (1) Kavli Institute for Systems Neuroscience, Centre for Neural Computation, 8 The Egil and Pauline Braathen and Fred Kavli Centre for Cortical Microcircuits, NTNU, 9 Norwegian University of Science and Technology, Trondheim, Norway; (2) Donders Institute 10 for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands; (3) UCL 11 Institute of Neurology, (4) UCL Institute of Cognitive Neuroscience; (5) UCL Research 12 Department of Cell and Developmental Biology, University College London, London, UK; (6) 13 MaX Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany 14 15 *Contact Information:
[email protected] or
[email protected] 16 17 Summary 18 Minimizing spatial uncertainty is essential for navigation, but the neural mechanisms remain 19 elusive. Here we combine predictions of a simulated grid cell system with behavioural and 20 fMRI measures in humans during virtual navigation. First, we showed that polarising cues 21 produce anisotropy in motion parallax. Secondly, we simulated entorhinal grid cells in an 22 environment with anisotropic information and found that self-location is decoded best when 23 grid-patterns are aligned with the axis of greatest information.