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POSTERS MONDAY JUNE 9TH POSTER SESSION MONDAY JUNE 9TH 2003 10.00 - 12.00 hrs. M473 Poster presentation number and reference number for the Abstract Book TH MONDAY JUNE 9 POSTERS Basic Science Acid-Base Organic solutes / Osmolytes / Renal metabolism M001-M012 Hormones / Peptides M013-M030 Receptors or intracellular mediators involved in lipid- derived signalling pathways M031-M065 Receptors or intracellular mediators involved in non- lipid-derived signalling pathways M066-M070 Immunology, immunopathology M071-M099 Pathophysiology of diabetes mellitus and diabetic complications M100-M141 General Nephrology Primary glomerular diseases: clinical M184-M256 Hypertension: clinical M257-M297 Diabetes mellitus: clinical M298-M350 Tubulointerstitial renal diseases, urinary tract infection, urolithiasis M351-M374 Clinical nephrology: miscellaneous M375-M395 Progression M396-M430 Vitamin D and PTH M431-M480 Erythropoietin M481-M527 Dialysis Dialysis - clinical; Adequacy and modelling M528-M561 Cardiovascular risk in ESRD, cardiac hypertrophy and atherosclerosis M562-M570 Oxidative stress - reactive oxygen species, AGE’s M571-M603 ESRD treatment comparisons M604-M637 Haemodialysis: uremic toxins M638-M657 PD solutions M658-M677 PD: peritonitis M678-M694 Transplantation Transplantation: basic, experimental M695-M735 Transplantation: outcomes, cardiovascular morbidity and mortality M736-M753 Transplantation: miscellaneous M754-M778 Paediatric Nephrology Pathophysiology, nephrotic syndrome M779-M793 Paediatric clinical nephrology, acute and chronic renal failure, bone and mineral metabolism, anaemia Nephrotic syndrome M794-M821 Miscellaneous M822-M855 Chronic renal failure M856-M874 Paediatric transplantation Immunology M875-M879 POSTERS MONDAY JUNE 9TH ACID-BASE M001 FUNCTIONAL ANALYSIS OF NBC1 MUTANTS RELATED TO PROXIMAL RENAL TUBULAR ACIDOSIS ON XENOPUS OOCYTES Shoko Horita,1 Hideomi Yamada,1 Yoshiro Suzuki,2 Jun Inatomi,3 Takashi Sekine,3 Katsumasa Kawahara,2 Toshiro Fujita,1 Takashi Igarashi,3 George Seki.1 1Internal Medicine, Tokyo University, Bunkyo-ku, Tokyo, Japan; 2Physiology, Kitasato University, Sagamihara, Kanagawa, Japan; 3Pediatrics, Tokyo University, Bunkyo-ku, Tokyo, Japan M002 ANP BLOCKS THE DOSE-DEPENDENT STIMULATORY EFFECT OF AVP ON H+-ATPASE IN MDCK CELLS MONDAY Maria Oliveira-Souza, Gerhard Malnic, Margarida Mello-Aires. Physiology and Biophysics, Instituto de Ciencias Biomedicas, São Paulo, SP, Brazil M003 KINETICS OF AN APICAL NA+/H+ EXCHANGER IN T84 COLON CELLS: EFFECT OF HEAT-STABLE E.COLI ENTEROTOXIN (STA) Marco Antonio Ramirez, Ana Rosa Beltran, Gerhard Malnic, Nancy A. Rebouças. Fisiologia e Biofisica, Inst. Ciencias Biomedicas USP, Sao Paulo, SP, Brazil M004 AVP MODULATES NA+/ H+ EXCHANGER IN EPITHELIAL COLON CELLS Raif Musa-Aziz, Margarida Mello-Aires. Physiology and Biophysics, Instituto de Ciencias Biomedicas - USP, São Paulo, SP, Brazil M005 DIFFERENTIAL LOCALIZATION OF VACUOLAR H+-ATPases CONTAINING THE a1, a2, a3, OR a4 (ATP6V0A1-4) SUBUNIT ISOFORMS ALONG THE NEPHRON Nicole Schulz, Mital H. Dave, Carsten A. Wagner. Institute of Physiology, University of Zurich, Zurich, Switzerland M006 RAPID NON-GENOMIC STIMULATION OF VACUOLAR H+- ATPase ACTIVITY IN OUTER MEDULLARY COLLECTING DUCT INTERCALATED CELLS BY ALDOSTERONE Christian Winter,1,2 Nicole Schulz,1 Gerhard Giebisch,2 John P. Geibel,2 Carsten A. Wagner.1 1Institute of Physiology, University of Zurich, Zurich, Switzerland; 2Department of Cellular and Molecular Physiology, School of Medicine, Yale University, New Haven, CT, United States M007 BIPHASIC REGULATION OF PROXIMAL BICARBONATE ABSORPTION BY LUMINAL ANGIOTENSIN II TYPE 1A RECEPTOR Shoko Horita,1 Yanan Zheng,1 Motoei Kunimi,1 Hideomi Yamada,1 Takeshi Sugaya,2 Toshiro Fujita,1 George Seki.1 1Internal Medicine, Tokyo University, Bunkyo-ku, Tokyo, Japan; 2Discovery Research Laboratory, Tanabe Seiyaku, Osaka, Japan M008 CLONING AND EXPRESSION OF SODIUM-BICARBONATE COTRANSPORTER ISOFORM IN RAT Kyu Y. Ahn, Han D. Yoon, Hee Y. Chung, Ji H. Kim, Kyung K. Kim. 1Department of Anatomy, Chonnam National University Medical School, Gwangju, Korea; 2Department of Anatomy, Chonnam National University Medical School, Gwangju, Korea; 3Department of Anatomy, Chonnam National University Medical School, Gwangju, Korea; 4Department of Anatomy, Chonnam National University Medical School, Gwangju, Korea; 5Department of Pharmacology, Chonnam National University Medical School, Gwangju, Korea TH MONDAY JUNE 9 POSTERS M009 ACID-BASE BALANCE REGULATES mRNA EXPRESSION LEVEL OF ANION EXCHANGER TYPE 4 BUT NOT ITS LOCALIZATION IN THE RABBIT KIDNEY Matsuhiko Hayashi,1 Hirohiko Tsuganezawa,1 Yasuyoshi Yamaji,2 Soichiro Sato,1 Takao Saruta.1 1Department of Intrernal Medicine, School of Medicine, Keio University, Shinanomachi, Shinjuku-ku, Tokyo, Japan; 2Department of internal Medicine, Saitama Social Insurance Hospital, Kitaurawa, Saitama City, Saitama Prefacture, Japan M010 NA+/H+ EXCHANGE ACTIVITY AND DIURETIC RESPONSE TO NOVEL NHE3 INHIBITORS IN THE SPONTANEOUSLY HYPERTENSIVE RAT (SHR) Michael S. LaPointe,1,2 Daniel Batlle.1,2 1Division of Nephrology, Feinberg School of Medicine, Northwestern University; 2VA Chicago HCS/Lakeside, Chicago, IL, United States M011 A1 ADENOSINE RECEPTOR INACTIVATION OF RENAL BRUSH BORDER MEMBRANE Na/H EXCHANGER NHE3 IS DEPENDENT ON INTERACTION WITH THE REGULATORY CALCINEURIN HOMOLOGOUS PROTEIN (CHP) Francesca Di Sole,1 Robert Cerull,1 Victor Babich,2 Henry Quinones,2 Gerhard Burckhardt,1 Corinna Helmle-Kolb,1 Orson W. Moe.2 1Physiology and Pathophysiology, Georg-August University of Goettingen, Goettingen, Germany; 2Internal Medicine, Division of Nephrology, UT Southwestern Medical Center Dallas, Dallas, TX, United States M012 FUNCTIONAL EXPRESSION OF RhCG IN Xenopus laevis OOCYTES Naziha Bakouh, Fatine Benjelloun, Philippe Hulin, Aleksander Edelman, Baya Cherif-Zahar, Gabrielle Planelles. Université Paris V. Faculté Necker-Enfants Malades, Inserm U 467, Paris, France ORGANIC SOLUTES/OSMOLYTES/ RENAL METABOLISM M013 MUTATIONS OF THE PUTATIVE PKC-DEPENDENT PHOSPHORYLATION SITES MODULATE ACTIVITY AND REGULATION OF THE RAT ORGANIC CATION TRANSPORTER rOCT1 Giuliano Ciarimboli,1 Valentin Gorboulev,2 Hermann Koepsell,2 Eberhard Schlatter.1 1Med. Klinik und Poliklinik D, Exp. Nephrologie, Universitaetsklinikum Muenster, Muenster, Germany; 2Institut fuer Anatomie und Zellbiologie, Universitaet Wuerzburg, Wuerzburg, Germany M014 THE HUMAN ORGANIC ANION TRANSPORTER 3 (hOAT3) IN ADRENOCORTICAL CELLS IS INVOLVED IN CORTISOL TRANSPORT Abdul Rahman Asif,1 R. Willi Grunewald,2 Christoph Langenberg,2 Maria Metten,3 Gerhard A. Müller,2 Gerhard Burckhardt,1 Yohannes Hagos.1 1Vegetative Physiologie, Zentrum Physiologie und Pathophysiologie; 2Abteilungen für Nephrologie und Rheumatologie; 3Klinische und Experimentelle Endokrinologie, Göttingen, Germany M015 GENDER DIFFERENCES IN THE EXPRESSION OF RAT RENAL OAT1 ARE DETERMINED BY BOTH ANDROGEN STIMULATION AND ESTROGEN INHIBITION Ivan Sabolic,1 Marija Ljubojevic,1 Carol M. Herak-Kramberger,1 Yohannes Hagos,2 Andrew Bahn,2 Hitoshi Endou,3 Gerhard Burckhardt.2 1Unit of Molecular Toxicology, Institute for Medical Research & Occupational Health, Zagreb, Croatia; 2Department of Physiology & Pathophysiology, University of Goettingen, Goettingen, Germany; 3Department of Pharmacology & Toxicology, Kyorin University School of Medicine, Tokyo, Japan M016 EGF ACTION ON BASOLATERAL ORGANIC ANION UPTAKE IN ISOLATED PROXIMAL RABBIT TUBULES (S2) AND HUMAN OAT1 EXPRESSED IN IMMORTALIZED HUMAN KIDNEY EPITHELIAL (IHKE) CELLS Christoph Sauvant,1 Dorothea Hesse,1 Hildegard Holzinger,1 Kristen Evans,2 William Dantzler,2 Michael Gekle.1 1Physiologisches Institut, Universitaet Wuerzburg, Wuerzburg, Bavaria, Germany; 2Department of Physiology, University of Arizona, Tucson, AZ, United States M017 HUMAN RENAL ORGANIC ANION TRANSPORTER 1 (hOAT1) INTERACTS WITH NEUROACTIVE TRYPTOPHAN METABOLITES Heiko Lorenz, Gerhard Burckhardt, Andrew Bahn. Vegetative Physiologie, Zentrum Physiologie und Pathophysiologie, Göttingen, Germany M018 TRANSPORT OF ORGANIC CATIONS IN FRESHLY ISOLATED RAT PROXIMAL TUBULES IS A MARKER OF ENERGY STATUS F. Pietruck, S. Blaschke, T. Feldkamp, Th. Philipp, A. Kribben. Department of Nephrology, University of Essen, Essen, Germany M019 IDENTIFICATION OF A NOVEL ORGANIC ANION TRANSPORTER OAT8 FROM THE RAT KIDNEY Hirokazu Yokoyama, Naohiko Anzai, Sophapun Chaekuntode, Ho Jung Shin, Rie Noshiro, Hiroki Miyazaki, Yoshikatsu Kanai, Hitoshi Endou. Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Mitaka-shi, Tokyo, Japan M020 IDENTIFICATION OF THE TRANSPORT MECHANISM MEDIATED BY THE LIFE-EXTENDING GENE INDY Felix Knauf,1 Carsten Teichert,1 Nilufar Mohebbi,1 Diana Herold,1 Blanka Rogina,2 Stephen Helfand,2 Peter S. Aronson,3 Maik Gollasch,1 Friedrich C. Luft.1 1Franz Volhard Clinic at the Max Delbruck Center, HELIOS Kliniken-Berlin, Medical Faculty Charite, Humboldt University, Berlin, Germany; 2Department of Genetics and Developmental Biology, School of Medicine, University of Connecticut Health Center, Framington, CT, United States; 3Department of Internal Medicine, Yale University School of Medicine, New Heaven, CT, United States M021 EFFECT OF HUMAN Na+/DICARBOXYLATE COTRANSPORTER 3 ON MITOCHONDRIAL MEMBRANE POTENTIAL IN HUMAN PROXIMAL TUBULAR EPITHELIAL CELLS Gen-Yang Chen, Xiang-Mei Chen, Zhe Feng, Bo Fu, Xue-Yuan Bai. Department of Nephrology, General Hospital of PLA, Beijing, China M022 CONTRIBUTION OF THE SODIUM-DEPENDENT DICARBOXYLATE TRANSPORTER
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    RESEARCH ARTICLE Protein-Bound Uremic Toxin Profiling as a Tool to Optimize Hemodialysis Sunny Eloot1*, Daniel Schneditz2, Tom Cornelis3, Wim Van Biesen1, Griet Glorieux1, Annemie Dhondt1, Jeroen Kooman3, Raymond Vanholder1 1 Nephrology Section, Department of Internal Medicine, Ghent University Hospital, Gent, Belgium, 2 Institute of Physiology, Medical University of Graz, Graz, Austria, 3 Division of Nephrology, Department of Internal Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands * [email protected] Abstract Aim We studied various hemodialysis strategies for the removal of protein-bound solutes, which are associated with cardiovascular damage. Methods OPEN ACCESS This study included 10 patients on standard (3x4h/week) high-flux hemodialysis. Blood was collected at the dialyzer inlet and outlet at several time points during a midweek session. Citation: Eloot S, Schneditz D, Cornelis T, Van Total and free concentration of several protein-bound solutes was determined as well as Biesen W, Glorieux G, Dhondt A, et al. (2016) Protein-Bound Uremic Toxin Profiling as a Tool to urea concentration. Per solute, a two-compartment kinetic model was fitted to the measured Optimize Hemodialysis. PLoS ONE 11(1): e0147159. concentrations, estimating plasmatic volume (V1), total distribution volume (Vtot) and inter- doi:10.1371/journal.pone.0147159 compartment clearance (K21). This calibrated model was then used to calculate which Editor: Tatsuo Shimosawa, The University of Tokyo, hemodialysis strategy offers optimal removal. Our own in vivo data, with the strategy vari- JAPAN ables entered into the mathematical simulations, was then validated against independent Received: October 30, 2015 data from two other clinical studies. Accepted: December 29, 2015 Results Published: January 22, 2016 Dialyzer clearance K, V1 and Vtot correlated inversely with percentage of protein binding.

  • CCW+GGE.1+2019+INF.1+Rev.1.Pdf

    CCW/GGE.1/2019/INF.1/Rev.1 Convention on Prohibitions or Restrictions on the 22 November 2019 Use of Certain Conventional Weapons Which May Be Deemed to Be Excessively Injurious English/French/Spanish only or to Have Indiscriminate Effects Group of Governmental Experts on Emerging Technologies in the Area of Lethal Autonomous Weapons Systems Geneva, 25-29 March and 20-21 August List of participants A. High Contracting Parties Algeria M. Boudjemâa Delmi Ambassadeur, Représentant permanent, Genève, Chef de délégation M. Rachid Bladehane Directeur Général des relations Multilatérales, Ministère des Affaires Etrangères M. Mourad Adjabi Directeur des Affaires Politiques Internationales, Ministère des Affaires Etrangères M. Toufik Djouama Ministre Conseiller, Mission permanente, Genève M. Abdellah Hafsi Ministère de la Défense Nationale M. Abdenour Hadid Direction Générale de la Sûreté Nationale M. Mohammed Traiche Ministère de l’Enseignement Supérieur et de la Recherche Scientifique Mme Sabrina Benmansour Ministère de la Justice M. Salim Berkat Premier secrétaire, Mission permanente, Genève Argentina Sr. Carlos Mario Foradori Embajador, Representante Permanente, Ginebra, Jefe de Delegación Sr. Germán Edmundo Proffen Ministro Plenipotenciario, Misión Permanente, Ginebra Sra. Mariá Jimena Schiaffino Consejero, Misión Permanente, Ginebra Srta. Estefanía Porta Secretariao de Embajada, Misión Permanente en Ginebra Sr. Iván Beltran Misión Permanente, Ginebra GE.19-20255(E) CCW/GGE.1/2019/INF.1/Rev.1 Australia Ms Sally Mansfield Ambassador to the