POSTERS MONDAY JUNE 9TH

POSTER SESSION MONDAY JUNE 9TH 2003

10.00 - 12.00 hrs.

M473 Poster presentation number and reference number for the Abstract Book TH MONDAY JUNE 9 POSTERS

Basic Science Acid-Base Organic solutes / Osmolytes / Renal metabolism M001-M012 Hormones / Peptides M013-M030 Receptors or intracellular mediators involved in lipid- derived signalling pathways M031-M065 Receptors or intracellular mediators involved in non- lipid-derived signalling pathways M066-M070 Immunology, immunopathology M071-M099 Pathophysiology of diabetes mellitus and diabetic complications M100-M141

General Nephrology Primary glomerular diseases: clinical M184-M256 Hypertension: clinical M257-M297 Diabetes mellitus: clinical M298-M350 Tubulointerstitial renal diseases, urinary tract infection, urolithiasis M351-M374 Clinical nephrology: miscellaneous M375-M395 Progression M396-M430 Vitamin D and PTH M431-M480 M481-M527

Dialysis Dialysis - clinical; Adequacy and modelling M528-M561 Cardiovascular risk in ESRD, cardiac hypertrophy and atherosclerosis M562-M570 Oxidative stress - reactive oxygen species, AGE’s M571-M603 ESRD treatment comparisons M604-M637 Haemodialysis: uremic toxins M638-M657 PD solutions M658-M677 PD: peritonitis M678-M694

Transplantation Transplantation: basic, experimental M695-M735 Transplantation: outcomes, cardiovascular morbidity and mortality M736-M753 Transplantation: miscellaneous M754-M778

Paediatric Nephrology Pathophysiology, nephrotic syndrome M779-M793 Paediatric clinical nephrology, acute and chronic renal failure, bone and mineral metabolism, anaemia Nephrotic syndrome M794-M821 Miscellaneous M822-M855 Chronic renal failure M856-M874 Paediatric transplantation Immunology M875-M879 POSTERS MONDAY JUNE 9TH

ACID-BASE

M001 FUNCTIONAL ANALYSIS OF NBC1 MUTANTS RELATED TO PROXIMAL RENAL TUBULAR ACIDOSIS ON XENOPUS OOCYTES Shoko Horita,1 Hideomi Yamada,1 Yoshiro Suzuki,2 Jun Inatomi,3 Takashi Sekine,3 Katsumasa Kawahara,2 Toshiro Fujita,1 Takashi Igarashi,3 George Seki.1 1Internal Medicine, Tokyo University, Bunkyo-ku, Tokyo, ; 2Physiology, Kitasato University, Sagamihara, Kanagawa, Japan; 3Pediatrics, Tokyo University, Bunkyo-ku, Tokyo, Japan

M002 ANP BLOCKS THE DOSE-DEPENDENT STIMULATORY EFFECT OF AVP ON H+-ATPASE IN MDCK CELLS MONDAY Maria Oliveira-Souza, Gerhard Malnic, Margarida Mello-Aires. Physiology and Biophysics, Instituto de Ciencias Biomedicas, São Paulo, SP, Brazil

M003 KINETICS OF AN APICAL NA+/H+ EXCHANGER IN T84 COLON CELLS: EFFECT OF HEAT-STABLE E.COLI ENTEROTOXIN (STA) Marco Antonio Ramirez, Ana Rosa Beltran, Gerhard Malnic, Nancy A. Rebouças. Fisiologia e Biofisica, Inst. Ciencias Biomedicas USP, Sao Paulo, SP, Brazil

M004 AVP MODULATES NA+/ H+ EXCHANGER IN EPITHELIAL COLON CELLS Raif Musa-Aziz, Margarida Mello-Aires. Physiology and Biophysics, Instituto de Ciencias Biomedicas - USP, São Paulo, SP, Brazil

M005 DIFFERENTIAL LOCALIZATION OF VACUOLAR H+-ATPases CONTAINING THE a1, a2, a3, OR a4 (ATP6V0A1-4) SUBUNIT ISOFORMS ALONG THE Nicole Schulz, Mital H. Dave, Carsten A. Wagner. Institute of Physiology, University of Zurich, Zurich, Switzerland

M006 RAPID NON-GENOMIC STIMULATION OF VACUOLAR H+- ATPase ACTIVITY IN OUTER MEDULLARY COLLECTING DUCT INTERCALATED CELLS BY Christian Winter,1,2 Nicole Schulz,1 Gerhard Giebisch,2 John P. Geibel,2 Carsten A. Wagner.1 1Institute of Physiology, University of Zurich, Zurich, Switzerland; 2Department of Cellular and Molecular Physiology, School of Medicine, Yale University, New Haven, CT, United States

M007 BIPHASIC REGULATION OF PROXIMAL BICARBONATE ABSORPTION BY LUMINAL ANGIOTENSIN II TYPE 1A RECEPTOR Shoko Horita,1 Yanan Zheng,1 Motoei Kunimi,1 Hideomi Yamada,1 Takeshi Sugaya,2 Toshiro Fujita,1 George Seki.1 1Internal Medicine, Tokyo University, Bunkyo-ku, Tokyo, Japan; 2Discovery Research Laboratory, Tanabe Seiyaku, Osaka, Japan

M008 CLONING AND EXPRESSION OF SODIUM-BICARBONATE COTRANSPORTER ISOFORM IN RAT Kyu Y. Ahn, Han D. Yoon, Hee Y. Chung, Ji H. Kim, Kyung K. Kim. 1Department of Anatomy, Chonnam National University Medical School, Gwangju, Korea; 2Department of Anatomy, Chonnam National University Medical School, Gwangju, Korea; 3Department of Anatomy, Chonnam National University Medical School, Gwangju, Korea; 4Department of Anatomy, Chonnam National University Medical School, Gwangju, Korea; 5Department of Pharmacology, Chonnam National University Medical School, Gwangju, Korea TH MONDAY JUNE 9 POSTERS

M009 ACID-BASE BALANCE REGULATES mRNA EXPRESSION LEVEL OF ANION EXCHANGER TYPE 4 BUT NOT ITS LOCALIZATION IN THE RABBIT KIDNEY Matsuhiko Hayashi,1 Hirohiko Tsuganezawa,1 Yasuyoshi Yamaji,2 Soichiro Sato,1 Takao Saruta.1 1Department of Intrernal Medicine, School of Medicine, Keio University, Shinanomachi, Shinjuku-ku, Tokyo, Japan; 2Department of internal Medicine, Saitama Social Insurance Hospital, Kitaurawa, Saitama City, Saitama Prefacture, Japan

M010 NA+/H+ EXCHANGE ACTIVITY AND DIURETIC RESPONSE TO NOVEL NHE3 INHIBITORS IN THE SPONTANEOUSLY HYPERTENSIVE RAT (SHR) Michael S. LaPointe,1,2 Daniel Batlle.1,2 1Division of Nephrology, Feinberg School of Medicine, Northwestern University; 2VA Chicago HCS/Lakeside, Chicago, IL, United States

M011 A1 ADENOSINE RECEPTOR INACTIVATION OF RENAL BRUSH BORDER MEMBRANE Na/H EXCHANGER NHE3 IS DEPENDENT ON INTERACTION WITH THE REGULATORY CALCINEURIN HOMOLOGOUS PROTEIN (CHP) Francesca Di Sole,1 Robert Cerull,1 Victor Babich,2 Henry Quinones,2 Gerhard Burckhardt,1 Corinna Helmle-Kolb,1 Orson W. Moe.2 1Physiology and Pathophysiology, Georg-August University of Goettingen, Goettingen, Germany; 2Internal Medicine, Division of Nephrology, UT Southwestern Medical Center Dallas, Dallas, TX, United States

M012 FUNCTIONAL EXPRESSION OF RhCG IN Xenopus laevis OOCYTES Naziha Bakouh, Fatine Benjelloun, Philippe Hulin, Aleksander Edelman, Baya Cherif-Zahar, Gabrielle Planelles. Université Paris V. Faculté Necker-Enfants Malades, Inserm U 467, Paris, France ORGANIC SOLUTES/OSMOLYTES/ RENAL METABOLISM

M013 MUTATIONS OF THE PUTATIVE PKC-DEPENDENT PHOSPHORYLATION SITES MODULATE ACTIVITY AND REGULATION OF THE RAT ORGANIC CATION TRANSPORTER rOCT1 Giuliano Ciarimboli,1 Valentin Gorboulev,2 Hermann Koepsell,2 Eberhard Schlatter.1 1Med. Klinik und Poliklinik D, Exp. Nephrologie, Universitaetsklinikum Muenster, Muenster, Germany; 2Institut fuer Anatomie und Zellbiologie, Universitaet Wuerzburg, Wuerzburg, Germany

M014 THE HUMAN ORGANIC ANION TRANSPORTER 3 (hOAT3) IN ADRENOCORTICAL CELLS IS INVOLVED IN CORTISOL TRANSPORT Abdul Rahman Asif,1 R. Willi Grunewald,2 Christoph Langenberg,2 Maria Metten,3 Gerhard A. Müller,2 Gerhard Burckhardt,1 Yohannes Hagos.1 1Vegetative Physiologie, Zentrum Physiologie und Pathophysiologie; 2Abteilungen für Nephrologie und Rheumatologie; 3Klinische und Experimentelle Endokrinologie, Göttingen, Germany

M015 GENDER DIFFERENCES IN THE EXPRESSION OF RAT RENAL OAT1 ARE DETERMINED BY BOTH ANDROGEN STIMULATION AND ESTROGEN INHIBITION Ivan Sabolic,1 Marija Ljubojevic,1 Carol M. Herak-Kramberger,1 Yohannes Hagos,2 Andrew Bahn,2 Hitoshi Endou,3 Gerhard Burckhardt.2 1Unit of Molecular Toxicology, Institute for Medical Research & Occupational Health, Zagreb, Croatia; 2Department of Physiology & Pathophysiology, University of Goettingen, Goettingen, Germany; 3Department of Pharmacology & Toxicology, Kyorin University School of Medicine, Tokyo, Japan

M016 EGF ACTION ON BASOLATERAL ORGANIC ANION UPTAKE IN ISOLATED PROXIMAL RABBIT TUBULES (S2) AND HUMAN OAT1 EXPRESSED IN IMMORTALIZED HUMAN KIDNEY EPITHELIAL (IHKE) CELLS Christoph Sauvant,1 Dorothea Hesse,1 Hildegard Holzinger,1 Kristen Evans,2 William Dantzler,2 Michael Gekle.1 1Physiologisches Institut, Universitaet Wuerzburg, Wuerzburg, Bavaria, Germany; 2Department of Physiology, University of Arizona, Tucson, AZ, United States

M017 HUMAN RENAL ORGANIC ANION TRANSPORTER 1 (hOAT1) INTERACTS WITH NEUROACTIVE TRYPTOPHAN METABOLITES Heiko Lorenz, Gerhard Burckhardt, Andrew Bahn. Vegetative Physiologie, Zentrum Physiologie und Pathophysiologie, Göttingen, Germany

M018 TRANSPORT OF ORGANIC CATIONS IN FRESHLY ISOLATED RAT PROXIMAL TUBULES IS A MARKER OF ENERGY STATUS F. Pietruck, S. Blaschke, T. Feldkamp, Th. Philipp, A. Kribben. Department of Nephrology, University of Essen, Essen, Germany

M019 IDENTIFICATION OF A NOVEL ORGANIC ANION TRANSPORTER OAT8 FROM THE RAT KIDNEY Hirokazu Yokoyama, Naohiko Anzai, Sophapun Chaekuntode, Ho Jung Shin, Rie Noshiro, Hiroki Miyazaki, Yoshikatsu Kanai, Hitoshi Endou. Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Mitaka-shi, Tokyo, Japan M020 IDENTIFICATION OF THE TRANSPORT MECHANISM MEDIATED BY THE LIFE-EXTENDING GENE INDY Felix Knauf,1 Carsten Teichert,1 Nilufar Mohebbi,1 Diana Herold,1 Blanka Rogina,2 Stephen Helfand,2 Peter S. Aronson,3 Maik Gollasch,1 Friedrich C. Luft.1 1Franz Volhard Clinic at the Max Delbruck Center, HELIOS Kliniken-Berlin, Medical Faculty Charite, Humboldt University, Berlin, Germany; 2Department of Genetics and Developmental Biology, School of Medicine, University of Connecticut Health Center, Framington, CT, United States; 3Department of Internal Medicine, Yale University School of Medicine, New Heaven, CT, United States

M021 EFFECT OF HUMAN Na+/DICARBOXYLATE COTRANSPORTER 3 ON MITOCHONDRIAL MEMBRANE POTENTIAL IN HUMAN PROXIMAL TUBULAR EPITHELIAL CELLS Gen-Yang Chen, Xiang-Mei Chen, Zhe Feng, Bo Fu, Xue-Yuan Bai. Department of Nephrology, General Hospital of PLA, Beijing,

M022 CONTRIBUTION OF THE SODIUM-DEPENDENT DICARBOXYLATE TRANSPORTER TO RENAL DETOXIFICATION BY TRANSLOCATION OF AN ANTIDOTE FOR LEAD AND MERCURY Birgitta Burckhardt, Juergen Steffgen, Gerhard Burckhardt. Physiology and Pathophysiology, University of Goettingen, Goettingen, Germany

M023 BASOLATERAL LOCALIZATION OF FLOUNDER Na+- DICARBOXYLATE COTRANSPORTER (fNaDC-3) IN THE KIDNEY OF PLEURONECTES AMERICANUS Juergen Steffgen,1 Hartmut Hentschel,2 Beate Schoelermann,2 Lars Kuehne,1 Gerhard Burckhardt,1 Birgitta Burckhardt.1 1Abt. Vegetative Physiologie und Pathophysiologie, Universitaet Goettingen, Goettingen, Germany; 2Max-Planck Institut fuer Molekulare Physiologie, Dortmund, Germany

M024 TISSUE pO2 IN THE RENAL CORTEX AND MEDULLA OF ANAESTHETISED RATS: EFFECT OF FLUCTUATIONS IN RENAL PERFUSION PRESSURE Leszek Dobrowolski,1 Bert Flemming,2 Thomas Wronski.2 1Laboratory of Renal & Body Fluid Physiology, M.Mossakowski Medical Research Centre,Polish Academy of Sciences, Warsaw, Poland; 2Johannes Müller Institut of Physiology, Humboldt University (Charité), Berlin, Germany

M025 THE PRECURSOR OF RENAL DOPAMINE IS TAKEN UP BY THE LAT2/4F2hc HETERO AMINO ACID EXCHANGER IN RENAL EPITHELIAL CELLS Patricio Soares-da-Silva, Paula Serrao, Maria Joao Pinho. Inst. Pharmacol. Ther., Fac. Medicine, Porto, Portugal

M026 cDNA CLONING AND FUNCTIONAL CHARACTERISTICS OF A NOVEL Na+-DEPENDENT GLUCOSE TRANSPORTER NaGLT1 IN RAT KIDNEY Naoshi Horiba, Satohiro Masuda, Ayako Takeuchi, Daisuke Takeuchi, Masahiro Okuda, Ken-ichi Inui. Pharmacy, Kyoto University Hospital, Kyoto, Japan

M027 OSMOSENSITIVE GENES IN MDCK CELLS RESPOND TO NH4Cl Franz X. Beck, Wolfgang Neuhofer, Maria L. Fraek, Monika Vastag. Department of Physiology, University, Munich, Germany

M028 OSMOREGULATION OF PARACELLIN-1 mRNA IN VIVO AND IN VITRO Li-Wen Lai, Orlantha Whitehair, Xuemei Cai, Devin Kim, Yeong-Hau H. Lien. Medicine, University of Arizona, Tucson, AZ, United States POSTERS MONDAY JUNE 9TH

M029 CHARACTERIZATION OF MAP17 INTERACTIONS THAT INDUCE SUGAR TRANSPORT IN XENOPUS OOCYTES Victor Sorribas,1 Miguel A. Lanaspa,1 Tatiana Blasco,1 Jose A. Carrodeguas,2 Julia Catalan,3 Manuel Sarasa,2 Nabil Halaihel,4 Moshe Levi.4 1Toxicology, University of Zaragoza, Zaragoza, Spain; 2Anatomy, University of Zaragoza, Zaragoza, Spain; 3Genetics, University of Zaragoza, Zaragoza, Spain; 4Division of Renal Diseases and Hypertension, University of Colorado Health Sciences Center, Denver, CO, United States

M030 GLUCAGON DECREASES UT-A1 UREA TRANSPORTER EXPRESSION IN NORMAL RAT INNER MEDULLARY COLLECTING DUCT A.J. Magaldi, Y. Yano, L.H. Kudo, L. Andrade, A.C. Rodrigues, Jr. MONDAY Basic Research Laboratory LIM 12, Clinical Hospital-Nephrology- FMUSP, São Paulo, Brazil TH MONDAY JUNE 9 POSTERS HORMONES/ PEPTIDES

M031 EARLY EFFECTS OF ALDOSTERONE ON SODIUM TRANSPORT IN CORTICAL COLLECTING DUCT CELLS: ROLE OF THE NON- GENOMIC SIGNALING PATHWAY Cathy Le Moellic,1 Claudia Capurro,2 Francoise Cluzeaud,1 Michel Fay,1 Nicolette Farman,1 Marcel Blot-Chabaud.1 1INSERM U478, Faculte de Medecine X. Bichat, Paris; 2Depto de Fisiologia, Laboratorio de Biomembranas Facultad de Medicina, Buenos Aires, Argentina

M032 IS THE EGF-RECEPTOR AN ALDOSTERONE-INDUCED PROTEIN? Michael Gekle, Claudia Schuster, Ruth Freudinger, Sigrid Mildenberger, Alexander W. Krug. Department of Physiology, Universität Würzburg, Würzburg, Germany

M033 MECHANISM OF MINERALOCORTICOID EFFECTS: CORELATION BETWEEN EXPRESSION OF aENaC, GILZ AND SGK-1 mRNA IN THE CORTICAL COLLECTING TUBULE AND Na AND K URINARY EXCRETION Olivier Muller,1 Rimma Parnova,2 Bernard Rossier,1 Dmitri Firsov,1 Horisberger Jean-Daniel.1 1Institute of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland; 2Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, Saint- Petersburg, Russian Federation

M034 ALDOSTERONE ENHANCES GENE EXPRESSION IN JUXTAGLOMERULAR CELLS Juergen Klar, Helga Vitzthum, Armin Kurtz. Institut fuer Physiologie, Universitaet Regensburg, Regensburg, Germany

M035 ALDOSTERONE POTENTIATES ANGIOTENSIN II-INDUCED MAP KINASE SIGNALING IN VASCULAR SMOOTH MUSCLE CELLS Istvan Mazak,1 Anette Fiebeler,1 Dominik N. Muller,1 Joon-Keun Park,2 Erdenechimeg Shagdarsuren,1 Carsten Lindschau,2 Ralf Dechend,1 Bernhard Pilz,1 Hermann Haller,2 Friedrich C. Luft.1 1Nephrology, Franz-Volhard-Clinic and Max-Delbruck-Center, Berlin, Germany; 2Nephrology, Medical School Hannover, Hannover, Germany

M036 RENIN SIMILAR TO THE SUBMAXILLARY GLAND IS EXPRESSED IN MOUSE MESANGIAL CELL: SUB-CELLULAR LOCALIZATION AND ANGIOTENSIN II GENERATION UNDER CONTROL AND GLUCOSE- STIMULATED CONDITIONS Cleber Leite, Aurilucia Leitao, Giovana Di Marco, Dulce Casarini, Mirian Boim. Medicine, Renal Division, Universidade Federal de São Paulo, São Paulo, SP, Brazil

M037 HYPOXIA/REOXIGENATION ATTENUATES THE EFFECT OF ANGIOTENSIN II (AII) IN MESANGIAL CELLS: ROLE OF NITRIC OXIDE (NO), E2 (PGE) AND ATP REGULATED K+ CHANNELS (KATP) Clara Ravizckas, Nestor Schor, Mirian Boim. Medicine, Renal Division, Universidade Federal de São Paulo, São Paulo, SP, Brazil POSTERS MONDAY JUNE 9TH

M038 LPS-INDUCED RENIN-ANGIOTENSIN SYSTEM (RAS) INHIBITION IN HUMAN MESANGIAL CELLS (HMC) IS BLOCKED BY HIGH AMBIENT GLUCOSE Waldemar S. Almeida, Giovana S. Di Marco, Dulce E. Casarini, Alexandre H. Campos, Nestor Schor. Medicine - Division Nephrology, UNIFESP-EPM, Sao Paulo, Brazil

M039 CO-LOCALIZATION OF N-DOMAIN ANGIOTENSIN-I CONVERTING ENZYME (ACE) WITH ANGIOTENSIN II (AII) AND ANGIOTENSIN 1-7 IN MESANGIAL CELLS FROM WISTAR AND SPONTANEOUSLY HYPERTENSIVE RATS (SHR) Maria Claudina Andrade,1 Giovana Di Marco,1 Vicente Teixeira,1 Renato Mortara,2 Nestor Schor,1 Dulce Casarini.1 1Medicine - Nephrology Division, Universidade Federal de São Paulo, São Paulo, Brazil; 2Parasitologia, Universidade Federal de MONDAY São Paulo, São Paulo, Brazil

M040 ANGIOTENSIN II ENHANCES LPS INDUCED INFLAMMATION IN THE KIDNEY BY UPREGULATION OF THE TOLL-LIKE RECEPTOR 4 Ulrich Wenzel, Rolf Stahl, Gunter Wolf. Medicine/Nephrology, University Hospital Hamburg, Hamburg, Germany

M041 IMCD CELLS ARE ABLE TO PRODUCE ANGIOTENSIN I- CONVERTING ENZYME (ACE) AND EXPRESS BRADYKININ RECEPTOR Beata Marie Quinto,1 Joao Pesquero,2 Edson Santos,2 Dulce Casarini.1 1Medicine, UNIFESP, Sao Paulo, Brazil; 2Biophysics, UNIFESP, Sao Paulo, Brazil

M042 ACE-INHIBITION IN RATS INCREASES VOLUME VIA ANGIOTENSIN II TYPE-1 RECEPTOR ACTIVATION Gregor Guron. Department of Nephrology, Institute of Internal Medicine, Sahlgrenska Hospital, Goteborg, Sweden

M043 HIGH GLUCOSE CONCENTRATION STIMULATES THE ACTIVITY OF RENIN ANGIOTENSIN SYSTEM (RAS) IN PRIMARY RAT MESANGIAL CELLS (MC) Daniela Vidotti, Priscila Cristovam, Cleber Leite, Dulce Casarini, Nestor Schor, Mirian Boim. Medicine - Renal Division, Universidade Federal de São Paulo, São Paulo, SP, Brazil

M044 AVE 0991 MIMICS ANGIOTENSIN-(1-7) RENAL EFFECTS BY INVOLVING THE G PROTEIN-COUPLED RECEPTOR Mas Sergio Pinheiro,1 Ana Cristina Silva,1 Markus Bleich,2 Thomas Walther,3 Robson Santos.1 1Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil; 2Aventis Pharma Deutschland GmbH, Frankfurt, Germany; 3Cardiology and Pneumology, University Hospital Benjamin Franklin, Free University, Berlin, Germany

M045 ANGIOTENSIN (1-7) BLOCKS ANGIOTENSIN II MEDIATED REDUCTION OF RENAL BLOOD FLOW (RBF) IN VIVO AND CONSTRICTION OF RENAL INTERLOBULAR ARTERIES IN VITRO Els A. van der Wouden, Robert H. Henning, Peter Ochodnicky, Dick de Zeeuw, Richard P.E. van Dokkum. Clinical Pharmacology, Groningen University Institute for Drug Exploration, Groningen, Netherlands TH MONDAY JUNE 9 POSTERS

M046 HIGH CALCIUM DIET DOWN-REGULATES RENAL ANGIOTENSIN CONVERTING ENZYME IN EXPERIMENTAL KIDNEY FAILURE Ilkka Pörsti,1 Peeter Kööbi,2 Pasi Jolma,2 Jarkko Kalliovalkama,2 Heikki Helin,3 Harry Holthöfer,4 Tuulikki Nyman,5 Ilkka Tikkanen.5 1Department of Internal Medicine, University of Tampere, Tampere, Finland; 2Department of Pharmacological Sciences, University of Tampere, Tampere, Finland; 3Department of Pathology, Tampere University Hospital, Tampere, Finland; 4Programme of Molecular Medicine, Biomedicum, Helsinki, Finland; 5Minerva Institute for Medical Research, Biomedicum, Helsinki, Finland

M047 THE SIMULTANEOUS BLOCKADE OF AT1 AND AT2 ANGIOTENSIN RECEPTORS DIMINISHES RENAL NF-kB ACTIVATION AND INFLAMMATORY CELL INFILTRATION DURING KIDNEY DAMAGE Marta Ruiz-Ortega,1 Vanesa Esteban,1 Monica Ruperez,1 Oscar Lorenzo,1 Yusuke Suzuki,1 Juan Rodriguez-Vita,1 Elsa Sanchez- Lopez,1 Sergio Mezzano,2 Jesus Egido.1 1Vascular and Renal Laboratory, Fundacion Jimenez Diaz. UAM, Madrid, Spain; 2Nephrology, Universidad Austral, Valdivia, Chile

M048 SUPPLIER DEPENDENT DIFFERENCES IN RENAL DOPAMINERGIC SYSTEM ACTIVITY IN WISTAR-HAN RATS Benedita Sampaio-Maia,1 Paula Serrao,1 Maria Augusta Vieira- Coelho,1 Manuel Pestana.2 1Institute of Pharmacology and Therapeutics, Faculty of Medicine, Porto, Portugal; 2Dep. of Nephrology, Faculty of Medicine, Porto, Portugal

M049 REDUCED RENAL DOPAMINERGIC SYSTEM ACTIVITY AND INCREASE IN BLOOD PRESSURE IN ¾ NEPHRECTOMIZED RATS Benedita Sampaio-Maia,1 Paula Serrao,1 Maria Augusta Vieira- Coelho,1 Manuel Pestana.2 1Institute of Pharmacology and Therapeutics, Faculty of Medicine, Porto, Portugal; 2Department of Nephrology, Faculty of Medicine, Porto, Portugal

M050 BLUNTED RENAL AND INTESTINAL DOPAMINERGIC ACTIVITIES IN HgCl2 INDUCED MEMBRANOUS NEPHROPATHY Benedita Sampaio-Maia,1 Paula Serrao,1 Manuela Moura,1 Manuel Pestana.2 1Institute of Pharmacology and Therapeutics, Faculty of Porto, Porto, Portugal; 2Dep. of Nephrology, Faculty of Medicine, Porto, Portugal

M051 DOPAMINE (DA) TURNOVER IN THE BRAIN OF RATS WITH CHRONIC RENAL FAILURE TREATED WITH ERYTHROPOIETIN (EPO) Piotr Ksiazek, Janusz Solski, Andrzej Ksiazek. Nephrology, University Medical School, Lublin, Poland

M052 EXPRESSION OF UROCORTIN-III/STRESSCOPIN, A NOVEL STRESS HORMONE, IN HUMAN KIDNEY Kazuhiro Takahashi,1 Kazuhito Totsune,2 Osamu Murakami,2 Masayuki Saruta,3 Hironobu Sasano,3 Shigeki Shibahara.1 1Department of Molecular Biology & Applied Physiology, 2Department of Medicine, 3Department of Pathology, Tohoku University School of Medicine, Sendai, Japan

M053 GUANYLATE CYCLASE C IS NOT THE RECEPTOR FOR GUANYLIN PEPTIDES IN MOUSE AND HUMAN CORTICAL COLLECTING DUCTS Aleksandra Sindic,1 Candan Basoglu,1 Jochen R. Hirsch,1 Ana Velic,1 Michaela Kuhn,2 Eberhard Schlatter.1 1Medizinische Klinik und Poliklinik D, Experimentelle Nephrologie, Universitaetsklinikum Muenster, Muenster, NRW, Germany; 2Institut fuer Pharmakologie und Toxikologie, Universitaetsklinikum Muenster, Muenster, NRW, Germany POSTERS MONDAY JUNE 9TH

M054 NDRG2 (N-Myc DOWNSTREAM REGULATED GENE 2) IS A NOVEL ANDROGEN TARGET GENE IN RAT CORTICAL COLLECTING DUCT Sheerazed Boulkroun, Marcel Blot-Chabaud, Nicolette Farman, Nathalie Courtois-Coutry. Faculte de Medecine X. Bichat, INSERM U478, Paris, France

M055 ROLE OF ANDROGEN RECEPTOR PATHWAY IN THE PROGRESSION OF AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE (ADPKD) Shizuko Nagao,1,2 Masatomo Kusaka,1 Hisahede Takahashi,1 Jared Grantham.2 1Education and Research Center of Animal Models for Human Diseases, Fujita Health University, Toyoake, Aichi, Japan; 2The Kidney Institute, The University of Kansas Medical Center, Kansas MONDAY City, KS, United States

M056 DUAL EFFECTS OF ENDOTHELIN-1(1-31) TO INDUCE MESANGIAL CELLS MIGRATION AND FACILITATES MONOCYTE RECRUITMENT THROUGH MCP-1 PRODUCTION BY MESANGIAL CELLS Toshiaki Tamaki,1 Keisuke Ishizawa,1 Shoji Kagami,2 Koichiro Tsuchiya,1 Masanori Yoshizumi.1 1Pharmacology, The University of Tokushima School of Medicine, Tokushima-City, Tokushima, Japan; 2Pediatrics, The University of Tokushima School of Medicine, Tokushima-City, Tokushima, Japan

M057 ENDOTHELIN-1 IN GLOMERULAR DISEASE Saraladevi Naicker,1 Rajashree Mahabeer,2 Prem Gathiram,3 Strini Naidoo,2 Deshandra Raidoo,2 Kanti Bhoola.4 1Division of Nephrology, University of Witwatersrand, Johannesburg, Gauteng, South Africa; 2Department of Clinical Pharmacology, University of Natal, Durban, Kwazulu-Natal, South Africa; 3Department of Physiology, University of Durban-Westville, Durban, Kwazulu-Natal, South Africa; 4Faculty of Health Sciences, Durban Institute of Technology, Durban, Kwazulu-Natal, South Africa

M057a THE EFFECT OF ESTROGENS ON INDICES OF RENAL DAMAGE IN A MODEL OF SPONTANEOUS GLOMERULOSCLEROSIS Marie-Luise Gross,1 Eberhard Ritz,2 Marcin Adamzcak,2 Nevin Al Harbi,2 Jan Kritl,2 Andreas Koch,1 Michael Schoemig,2 Kerstin Amann.3 1Dept. of Pathology, University of Heidelberg, Heidelberg, Germany; 2Dept of Nephrology, Internal Medicine, Heidelberg, Germany; 3Pathologic Institute, University of Heidelberg, Erlangen, Germany

M058 UPREGULATION OF THE PEPTIDE TRANSPORTER PEPT2 IN PROXIMAL TUBULES OF HYPOTHYROID RATS Roland Schmitt,1 Maja Klapper,2 Frank Doering,2 Sebastian Bachmann,1 David Groneberg.3 11Department of Anatomy, Germany, Humboldt-University of Berlin, Berlin, Germany; 2Institute of Nutritional Science, Molecular Nutrition Unit, Technical University of Munich, Munich, Germany; 3Department of Medicine, Research Center Borstel, University of Luebeck, Luebeck, Germany

M059 EXPRESSION OF TAMM HORSFALL PROTEIN IN MEDULLARY THICK ASCENDING LIMB IS REDUCED IN HYPOTHYROIDISM Roland Schmitt, Kerim Mutig, Jan-Henning Fruehauf, Sebastian Bachmann. Department of Anatomy, Humboldt-University of Berlin, Berlin, Germany TH MONDAY JUNE 9 POSTERS

M060 VASCULAR BED-SPECIFIC INDUCTION OF ENDOTHELIAL NITRIC OXIDE SYNTHASE BY SYSTEMIC ADMINISTRATION OF VASCULAR ENDOTHELIAL GROWTH FACTOR Md. Ruhul Abid,1 Okan Cinkilic,1,2 Hermann Haller,2 William C. Aird.1 1Department of Medicine, Harvard Medical School, Beth Deaconess Medical Center, Boston, MA, United States; 2Department of Nephrology, Hannover Medical School, Hannover, Germany

M061 AUGMENTED RENAL PRODUCTION OF ADRENOMEDULLIN (AM) AND RENOPROTECTIVE EFFECTS OF EXOGENOUS AM IN TWO DIFFERENT MODELS OF ACUTE RENAL FAILURE Shin-ichi Suga,1 Fumiki Yoshihara,2 Takeshi Horio,2 Kenji Kangawa.1 1Research Institute, National Cardiovascular Center, Suita, Osaka, Japan; 2Medicine, National Cardiovascular Center, Suita, Osaka, Japan

M062 DOWNREGULATION OF ENDOGENOUS ADRENOMEDULLIN DURING EXPERIMENTAL GLOMERULONEPHRITIS - ROLE FOR MESANGIAL CELL PROLIFERATION Christian Plank,1 Andrea Hartner,2 Bernd Klanke,2 Wolfgang Rascher,1 Jörg Dötsch.1 1Klinik für Kinder und Jugendliche, Universität Erlangen-Nürnberg, Erlangen, Germany; 2Medizinische Klinik IV, Universität Erlangen- Nürnberg, Erlangen, Germany

M063 DIADENOSINE PHOSPHATES AND THE PHYSIOLOGICAL CONTROL OF BLOOD PRESSURE Joachim Jankowski, Walter Zidek. Med. Klinik IV, Universitätsklinkum Benjam Franklin, Berlin, Germany

M064 DINUCLEOSIDE DIPHOSPHATES Ap2A, Ap2G AND Gp2G: GROWTH PROMOTING MEDIATOR ISOLATED FROM RELEASABLE GRANULES OF HUMAN PLATELETS Joachim Jankowski, Markus van der Giet, Hartmut Schlüter, Walter Zidek. Med. Klinik IV, Universitätsklinikum Benjamin Franklin, Berlin, Germany

M065 STABILISATION OF HIF IS NECESSARY BUT NOT SUFFICIENT FOR EPO GENE EXPRESSION IN RENAL CELL CARCINOMA Michael S. Wiesener,1 Markus Glaeser,1 Philine Muenchenhagen,1 Christina Warnecke,1 Ulrich Frei,1 Herman-J. Groene,2 Kai-Uwe Eckardt.1 1Nephrology and Medical Intensive Care, CharitéCampus Virchow, Humboldt University, Berlin, Germany; 2Cellular and Molecular Pathology, German Cancer Research Centre, Heidelberg, Germany POSTERS MONDAY JUNE 9TH

RECEPTORS OR INTRACELLULAR MEDIA- TORS INVOLVED IN LIPID-DERIVED SIGNALLING PATHWAYS

M066 A COMPARITIVE STUDY OF THE EFFECTS OF FARNESYL TRANSFERASE INHIBITORS AND GERANYLGERANYL TRANSFERASE INHIBITORS ON RENAL FIBROGENESIS IN VITRO Rosemary Masterson,1,2 Tim Hewitson,1,2 Marina Martic,1 Kristen Kelynack,1 Gavin Becker.1,2 1Department of Nephrology, Royal Melbourne Hospital, Melbourne, Victoria, Australia; 2Department of Medicine, Melbourne University, MONDAY Melbourne, Victoria, Australia

M067 OMEGA 3 POLYUNSATURATED FATTY ACIDS (PUFA) INHIBITS NF KAPPA B ACTIVITY IN LPS-STIMULATED HK-2 CELLS THROUGH A PPAR GAMMA MEDIATED PATHWAY Hang Li, Xiong Z. Ruan, John F. Moorhead, Stephen H. Powis, Zac Varghese. Centre for Nephrology, Royal Free and University College Medical School, London, United Kingdom

M068 REGULATION OF THE EXPRESSION OF PROSTAGLANDIN RECEPTORS IN EXPERIMENTAL NEPHRITIS Christoph Waldner,1 Bernd Grabensee,1 Karsten Schrör,2 Peter Heering.1 1Nephrology, Heinrich Heine University, Düsseldorf, Germany; 2Pharmacology, Heinrich Heine University, Germany

M069 ACE INHIBITION AND AT1R BLOCKADE DECREASE EXPRESSION OF SEVERAL GENES OF THE ARACHIDONIC ACID PATHWAY IN SHRSP Torsten Kirsch,1 Maren Wellner,2 Anja Sieber,1 Martina Flechsig,1 Anna Klischat,1 Hermann Haller,1 Andrea Lippoldt.1 1Dept. of Nephrology, Medical School, Hannover, Germany; 2Helios Clinic, Franz Volhard Clinic at the Max-Delbruck Center for Molecular Medicine, Berlin, Germany

M070 PGE2 RECEPTOR EP4 SIGNALS RENIN ACTIVATION UPON VOLUME DEPLETION Rolf M. Nüsing,1 Charlotte Wagner,2 Armin Kurtz,2 Shuh Narumiya,3 Hannsjörg W. Seyberth.1 1Dept. of Pediatrics, Philipp´s University, Marburg, Germany; 2Institute of Physiology, University of Regensburg, Regensburg, Germany; 3Dept. of Pharmacology, Kyoto University, Kyoto, Japan TH MONDAY JUNE 9 POSTERS

RECEPTORS OR INTRACELLULAR MEDIA- TORS INVOLVED IN LIPID-DERIVED SIGNALLING PATHWAYS

M071 ROLE OF NUCLEAR FACTOR kB (NF-kB) AND MITOGENIC ACTIVATED PROTEIN KINASES (MAP KINASES) ON THE EVOLUTION OF TUBULOINTERSTITIAL NEPHRITIS INDUCED BY GENTAMICIN Rildo A. Volpini,1 Roberto S. Costa,2 Cleonice G.A. Silva,1 Terezila M. Coimbra.1 1Department of Physiology, 2Department of Pathology, Faculty of Medicine - USP, Ribeirão Preto, SP, Brazil

M072 NF-kB INHIBITION BY A TAT-NEMO-BINDING DOMAIN PEPTIDE ACCELERATES CONSTITUTIVE APOPTOSIS AND ABROGATES LPS-DELAYED NEUTROPHIL APOPTOSIS Mira Choi,1 Susanne Rolle,1 Maren Wellner,1 Claus Scheidereit,2 Cristina Cardoso,2 Friedrich Luft,1 Ralph Kettritz.1 1Nephrology, HELIOS Klinikum-Berlin, Franz Volhard Clinic, Medical Faculty of the Charite´ Humboldt University of Berlin, Berlin, Germany; 2Max Delbruek Center for Molecular Medicine, Berlin, Germany

M073 RHO KINASE AND PAI-1 IN BARTTER’S AND GITELMAN’S SYNDROMES. RELEVANCE FOR ANGIOTENSIN II SIGNALING Lorenzo Calo,1 Elisa Pagnin,1 Francesca Zaghetto,1 Paul Davis,2 Michelangelo Sartori,1 Andrea Semplicini.1 1Clinical and Experimental Medicine, Clinica Medica 4, University of Padova, Padova, Italy; 2Internal Medicine, Clin Nutrition, University of California, Davis, Davis, CA, United States

M074 THE EFFECT OF FASUDIL ON RHO-KINASE AND NEPHROPATHY IN SUBTOTALLY NEPHRECTOMIZED SPONTANEOULY HYPERTENSIVE RATS Takeshi Kanda, Shu Wakino, Koichi Hayashi, Koichiro Homma, Kyoko Yoshioka, Ichiro Takamatsu, Satoru Tatematsu, Takao Saruta. Internal Medicine, Keio University, Tokyo, Japan

M075 RETINOID RECEPTORS: LOSS OF CORRELATION WITH THE VITAMIN D RECEPTOR IN EXPERIMENTAL RENAL FAILURE Balazs Györffy,1 Adam Vannay,2 Erika Heninger,2 Tivadar Tulassay,1,2 Andras Szabo.1 11st Dept of Paediatrics, Semmelweis University, Budapest, Hungary; 2Research Laboratory for Paediatrics and Nephrology, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary

M076 ROLE OF FAS RECEPTOR IN THE APPEARENCE OF GLOMERULA TRHROMBOSIS DURING ENDOTOXEMIA Silvia Sainz,1 Rosa Ortega,2 Rafael Ramirez,1 Domingo del Castillo.3 1Research Unit, Hospital Reina Sofia, Cordoba, Spain; 2Pathology Department, Hospital Reina Sofía, Cordoba, Spain; 3Nephrology Department, Hospital Reina Sofia, Cordoba, Spain

M077 ACTIVATION OF STAT3 IN CHRONIC SERUM SICKNESS (CSS) NEPHRITIS IN RATS Wu-Xing Zhang, Xiang-Mei Chen, Jian-Zhong Wang, Xiao-Dan Wang, Quan Hong. Department of Nephrology, General Hospital of PLA, Beijing, China POSTERS MONDAY JUNE 9TH

M078 EFFECTS OF BLOCKING RENIN-ANGIOTENSIN SYSTEM ON EXPRESSION AND TRANSLOCATION OF PROTEIN KINASE C ISOFORMS IN THE KIDNEY OF DIABETIC RATS Li Zhang,1 Ji Ma,2 Shanyan Lin.2 1Division of Nephrology, Jiangsu Province Hospital, Nanjing, Jiangsu Province, China; 2Division of Nephrology, Fudan University Huashan Hospital, Shanghai, China

M079 BLOCKING Ca2+ ENTRY IN RENAL EPITHELIAL CELLS DECREASES PI3 KINASE PHOSPHORYLATION OF Akt AND ALLOWS cAMP TO STIMULATE ERK THROUGH B-Raf SIGNALING Tamio Yamaguchi, Darren Wallace, Jared Grantham, James Calvet. Kidney Institute, University of Kansas Medical Center, Kansas City, KS, United States MONDAY

M080 THE MITOGEN-ACTIVATED PROTEIN KINASE Erk5 IS ACTIVATED IN HUMAN MESANGIAL CELLS Fernando Dorado,1 Atanasio Pandiella,2 José Miguel López-Novoa,1 Alicia Rodríguez-Barbero.1 1Fisiología y Farmacología, Universidad de Salamanca, Salamanca, Spain; 2Instituto de Microbiología Bioquímica, Consejo Superior de Investigaciones Científicas, Universidad de Salamanca, Salamanca, Spain

M081 THE MAP-KINASE ERK REGULATES GLOMERULAR CDK2 ACTIVITY AND PROLIFERATION IN ANTI-THY1 NEPHRITIS Dirk Bokemeyer,1 Darius Panek,1 Masashi Kitahara,2 Jim M. Trzaskos,3 Jürgen Floege,2 Herbert J. Kramer,1 Tammo Ostendorf.2 1Medical Policlinic, University of Bonn, Bonn, Germany; 2Div. of Nephrology and Immunology, RWTH Aachen, Aachen, Germany; 3Bristol-Myers Squibb Co., Lawrenceville, NJ, United States

M082 PDGF-INDUCED TRANSDIFFERENTIATION OF RENAL PROXIMAL TUBULAR CELLS IS MEDIATED BY p38 MAPK ACTIVATION Mei Zhang, Xiaomei Li. Renal Division, Department of Medicine, First Hospital and Institute of Nephrology, Peking University, Beijing, China

M083 p38 MAPK ACTIVATION AND CELL LOCALISATION IN HUMAN GLOMERULONEPHRITIS: CORRELATION WITH RENAL INJURY Cosimo Stambe,1 David Nikolic-Paterson,1 Prudence Hill,2 John Dowling,3 Robert Atkins.1 1Department of Nephrology and Monash University Department of Medicine, Monash Medical Centre, Melbourne, Victoria, Australia; 2Department of Anatomical Pathology, St Vincents Hospital, Melbourne, Victoria, Australia; 3Department of Anatomical Pathology, Monash Medical Centre, Melbourne, Victoria, Australia

M084 THE EXPRESSION OF PEROXISOME PROLIFERATORS- ACTIVATED RECEPTORS G IN UUO RATS Ji Ma, Qin Lin, Yong Gu, Jing Chen, Shaojun Liu, Shanyan Lin. Division of Nephrology, Huashan Hospital, Shanghai, China

M085 GAS6/AXL SIGNALING IN HUMAN INFLAMMATORY RENAL DISEASE Anette Fiebeler,1 Joon-Keun Park,2 Dominik N. Muller,1 Carsten Lindschau,2 Michael Mengel,2 Ralf Dechend,1 Friedrich C. Luft,1 Hermann Haller.2 1Nephrologie, Franz-Volhard-Clinic, HELIOS, Berlin, Germany; 2Nephrology, Medical School Hannover, Hannover, Germany TH MONDAY JUNE 9 POSTERS

M086 ILK EXPRESSION IN HUMAN PROTEINURIC GLOMERULAR DISEASE: AN IMMUNOHISTOCHEMISTRY APPROACH Rogerio Barbosa de Deus, Gianna Mastroianni Kirsztajn, Vicente de Paulo Castro Teixeira. Medicine / Division of Nephrology, Universidade Federal de Sao Paulo, Sao Paulo, Brazil

M087 LONG-TERM PROTECTIVE EFFECT OF Ras INHIBITION ON ACUTE RENAL FAILURE (ARF) BY ISCHEMIA-REPERFUSION INJURY Antonio Pisani,1 Roberto Paternò,2 Vittorio Serio,1 Francesco Mirenghi,1 Michele Andreucci,3 Maria Rosaria Santillo,2 Enrico Avvedimento,2 Massimo Sabbatini.1 1Department of Nephrology, University Federico II, Naples, Italy; 2Department of Experimental Medicine, University Federico II, Naples, Italy; 3Chair of Nephrology, University of Catanzaro, Catanzaro, Italy

M088 NUCLEAR FACTOR-kB INHIBITION ATTENUATES RENAL INJURY IN THE 5/6 RENAL ABLATION MODEL (NX) Glaucia R. Antunes, Jose M. Vieira, Jr., Ana L. Mattar, Luciana F. Carvalho, Denise M.A.C. Malheiros, Roberto Zatz, Clarice K. Fujihara. Renal Division, Dep. Clinical Medicine, University of São Paulo, São Paulo, SP, Brazil

M089 L-ARGININE IMPROVES PATHOLOGICALLY ACTIVATED CO- METABOLISM IN ISCHEMIC ACUTE RENAL FAILURE Reinhard Schneider,1 Ulrike Raff,1 Monika Schmidt,1 Ralf Freund,1 Nicole Vornberger,1 Stepan Gambaryan,2 Christoph Wanner,1 Jan Galle.1 1Dept. Medicine, Div. Nephrology, Bayerische Julius-Maximilians University, Wuerzburg, Germany; 2Institute of Clinical Biochemistry and Pathobiochemistry, Bayerische Julius-Maximilians University, Wuerzburg, Germany

M090 CROSS TALK BETWEEN SEROTONIN (5HT2A) AND EPIDERMAL GROWTH FACTOR RECEPTORS (EGFR) INVOLVES HEPARIN- BINDING EGF-LIKE GROWTH FACTOR (HB-EGF) AND ACTIVATION OF METALLOPROTEINASE-LIKE ENZYME(S) IN RAT MESANGIAL CELLS Monika Gooz, John R. Raymond, Maria N. Garnovskaya. Department of Medicine, Division of Nephrology, Medical University of South Carolina, Charleston, SC, United States

M091 OVEREXPRESSION OF CAVEOLIN-1 IN MESANGIAL CELLS INHIBITS PHOSPHORYLATION OF ERK1/2 AND CELL PROLIFERATION STIMULATED BY BASIC FIBROBLAST GROWTH FACTOR AND PLATELET-DERIVED GROWTH FACTOR Yutaka Fujita,1,2 Shoichi Maruyama,1 Hiroshi Kogo,2 Toyoshi Fujimoto,2 Seiichi Matsuo.1 1Clinical Immunology, Department of Internal Medicine, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan; 2Department of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan

M092 MOLECULAR MECHANISMS OF IFNa INDUCED PARACELLULAR PERMEABILITY INCREASE IN LLC-PK1 RENAL PROXIMAL TUBULAR MONOLAYERS Judith Lechner, Walter Pfaller. Institute of Physiology, University of Innsbruck, Innsbruck, Tyrol, Austria POSTERS MONDAY JUNE 9TH

M093 INHIBITION OF THE RENIN-ANGIOTENSIN-SYSTEM AMELIORATES VASCULAR FUNCTION IN SHRSP CEREBRAL MICROCAPILLARIES Torsten Kirsch,1 Maren Wellner,2 Martina Flechsig,1 Anna Klischat,1 Anja Sieber,1 Hermann Haller,1 Andrea Lippoldt.1 1Dept. of Nephrology, Medical School, Hannover, Germany; 2Helios Clinic, Franz Volhard Clinic at the Max-Delbruck Center for Molecular Medicine, Berlin, Germany

M094 STRUCTURALLY DIFFERENT PROLYL HYDROXYLASE INHIBITORS ACTIVATE HYPOXIA-INDUCIBLE FACTORS IN VITRO AND IN VIVO IN RAT KIDNEYS AND INDUCE ANGIOGENESIS IN A RAT SPONGE MODEL Christina Warnecke,1 Wanja Griethe,1 Alexander Weidemann,1 Jan Steffen Juergensen,1 Carsten Willam,1 Sebastian Bachmann,2 Yuri MONDAY Ivashchenko,3 Ingrid Wagner,3 Ulrich Frei,1 Michael Wiesener,1 Kai- Uwe Eckardt.1 1Dept. of Nephrology and Medical Intensive Care, University Clinic Charite, Humboldt University Berlin, Berlin, Germany; 2Dept. of Anatomy, University Clinic Charite, Humboldt University Berlin, Berlin, Germany; 3Dept. of Cardiovascular Diseases, Aventis Pharma Deutschland GmbH, Frankfurt a. M., Germany

M095 EXPRESSION OF HYPOXIA-INDUCIBLE FACTORS IN HUMAN KIDNEY Shuntaro Hara,1 Yukihiro Kondo,2 Tomoko Hosomi,1 Junko Hamada,1 Taiji Nishimura,2 Manabu Kunimoto.1 1Department of Public Health and Molecular Toxicology, School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan; 2Department of Urology, Nippon Medical School, Tokyo, Japan

M096 SUPPRESSORS OF CYTOKINE SIGNALING (SOCS) REGULATE ANGIOTENSIN II-ACTIVATED INFLAMMATORY PROCESSES IN THE KIDNEY Purificacion Hernandez-Vargas,1 Oscar Lopez-Franco,1 Guillermo Sanjuan,1 Monica Ruperez,1 Yusuke Suzuki,1 Julia Blanco,2 Takeshi Sugaya,3 Jesus Egido,1 Marta Ruiz-Ortega,1 Carmen Gomez- Guerrero.1 1Renal and Vascular Research Laboratory, Fundacion Jimenez Diaz, UAM; 2Department of Pathology, Hospital Clinico, UCM, Madrid, Spain; 3Discovery Research Laboratory, Tanabe-Seiyaku Co. Ltd., Japan

M097 CD40/CD40L INTERACTION IN RENAL CELL CARCINOMA (RCC): AN INTRACELLULAR SIGNALING STUDY M. Cellie,1 P. Pontrelli,1 C. Di Natale,1 A. Blasi,1 C. Capobianco,1 V. Mancini,2 P. Ditonno,2 M. Battaglia,2 F.P. Selvaggi,2 W.J. Storkus,3 G. Grandaliano,1 F.P. Schena,1 L. Gesualdo,4 E. Ranieri.1 1D.E.T.O., Section of Nephrology, University of Bari, Italy; 2D.E.T.O., Section of Surgical Nephrology, University of Bari, Italy; 3Dept. of Surgery, University of Pittsburgh, PA, United States; 4Chair of Nephrology, University of Foggia, Italy

M098 DFFERENTIAL EXPRESSION OF TNF-RECEPTORS 1 AND 2 ON CD4+-CELLS IN WEGENER’S DISEASE; MTCD; SCLERODERMIA; DERMATOMYOSITIS AND CROHN’S DISEASE Geraldine Zeller, Isabelle Pramana, Eveline Wandel, Peter Galle, Andreas Schwarting, Martin Holtmann. Ist Departement of Medicine, University Hospital, University Mainz, Mainz, Rheinland-Pfalz, Germany TH MONDAY JUNE 9 POSTERS

M099 ACTIVATION OF RAS PATHWAY IN TUBULO-INTERSTITIAL FIBROSIS INDUCED BY UNILATERAL URETERAL OBSTRUCTION IN MICE Ana Rodriguez-Peña,1 Neil Docherty,1 Carmen Guerrero,2 Maria Teresa Grande,1 Eugenio Santos,2 Angel Sanchez,3 Nelida Eleno,1 Jose Miguel Lopez-Novoa.1 1Fisiologia y Farmacologia, Instituto Reina Sofia de Investigacion Nefrologica. Universidad de Salamanca, Salamanca, Spain; 2Centro de Investigacion del Cancer, Lab.1, CSIC-Universidad de Salamanca, Salamanca, Spain; 3Unidad de Hipertension, Hospital Universitario de Salamanca, Salamanca, Spain POSTERS MONDAY JUNE 9TH

IMMUNOLOGY, IMMUNOPATHOLOGY

M100 BACTERIAL CpG-DNA INDUCES PROGRESSION OF RENAL DISEASE IN MRL-FAS (lpr) MICE BY ACTIVATION OF TOLL-LIKE RECEPTOR-9 ON RENAL MACROPHAGES AND DENDRITIC CELLS Hans-Joachim Anders,1 Volker Vielhauer,1 Matthias Kretzler,1 Guillermo Perez de Lema,1 Hermann-Josef Grone,2 Detlef Schlondorff.1 1Nephrological Center, University of Munich, Muenchen, Germany; 2Dept. of Cellular and Molecular Pathology, DKFZ, Heidelberg, Germany MONDAY M101 EFFECTS OF RECOMBINANT ADENOVIRUS CARRYING UTEROGLOBIN GENE ON EXPERIMENTAL GN IN MICE Hyun Lee Kim,1 Yon Su Kim,2 Dong-Sup Lee,3 Jong Hoon Chung,1 Curie Ahn,2 Jin Suk Han,2 Suhnggwon Kim,2 Jung Sang Lee.2 1Department of Internal Medicine, College of Medicine, Chosun University, Gwangju, Korea; 2Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea; 3Department of Anatomy, Seoul National University College of Medicine, Seoul, Korea

M102 DETERMINATION OF THE SPECIFIC THY-1 EPITOPE IN RAT MESANGIAL CELLS Tetsuo Morioka, Jian Yao, Takashi Oite. Cellular Physiology, Institute of Nephrology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan

M103 HUMAN MESANGIAL CELLS EXPRESS MANNAN BINDING LECTIN, A MEDIATOR FOR BINDING OF IGA Ralf Westerhuis,1 Masashi Kitahara,1 Mohamed R. Daha,2 Anja Roos,2 Jürgen Floege.1 1Dept. of Nephrology, University Hospital Aachen, Aachen, Germany; 2Dept. of Nephrology, Leiden University Medical Center, Leiden, Netherlands

M104 THE POLYMERIC STATE OF IgA IS REQUIRED FOR VIA Fca RECEPTOR I (CD89) Toshinao Tsuge, Michelle Arcos-Fajardo, Ivan C. Moura, Emmanuelle Gaudin, Renato C. Monteiro. Bichat Medical School, INSERM E0225, Paris, France

M105 IgA1-CONTAINING CIRCULATING IMMUNE COMPLEXES (CIC) FROM IgA NEPHROPATHY (IgAN) PATIENTS DIFFERENTIALLY STIMULATE OR INHIBIT PROLIFERATION OF MESANGIAL CELLS (MC) IN VITRO Jan Novak, Milan Tomana, Rhubell Brown, Karel Matousovic, Stacy Hall, Lea Novak, Bruce Julian, Jiri Mestecky. Departments of Microbiology, Medicine, and Surgery, University of Alabama at Birmingham, Birmingham, AL, United States

M106 COUPLED INDUCTION OF iNOS AND p53 IN RENAL RESIDENT CELLS MAY BE LINKED TO PRO-APOPTOTIC ACTIVITY IN THE PATHOGENESIS OF PROGRESSIVE IgAN Lianqun Qiu, Stephen I.-H. Hsu. Faculty of Medicine, National University of Singapore, Singapore

M107 SPONTANEOUS IgA NEPHROPATHY IN TRANSGENIC MICE EXPRESSING MUTATED IgA Fc RECEPTOR (CD89) WHICH CANNOT ASSOCIATE WITH THE FcR -g CHAIN Michelle Arcos-Fajardo, Ivan C. Moura, Renato C. Monteiro. Bichat Medical School, INSERM E0225, Paris, France TH MONDAY JUNE 9 POSTERS

M108 REGION ENCOMPASSING THE AMINO ACIDS 182-309 OF gp600/ MEGALIN CONTAINS THE MAJOR EPITOPES OF ACTIVE HEYMANN NEPHRITIS Bihua Li, Alfonso Tramontano, Sudesh Makker. Pediatrics, University of California, Davis, Davis, CA, United States

M109 EXPRESSION OF PODOCYTE ASSOCIATED PROTEINS IN PASSIVE AND ACTIVE HEYMANN NEPHRITIS: NOT THE ALTERATION OF INTEGRIN BUT THAT OF SLIT DIAPHRAGM ASSOCIATED PROTEINS IS ESSENTIAL FOR PROTEINURIA Takeshi Nakatsue,1 Hiroko Koike,1 Gi Dong Han,1 Fumitake Gejyo,2 Fujio Shimizu,1 Hiroshi Kawachi.1 1Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan; 2Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan

M110 DNA VACCINATION AGAINST SPECIFIC PATHOGENIC T CELL RECEPTORS REDUCES PROTEINURIA IN ACTIVE HEYMANN NEPHRITIS BY INDUCING SPECIFIC AUTOANTIBODIES Huiling Wu, Giles Walters, John Knight, Stephen Alexander. Centre for Kidney Research, The Children’s Hospital at Westmead, Sydney, NSW, Australia

M111 SPECTRUM OF MONOCLONAL AUTOANTIBODIES PRODUCED BY RATS INJECTED WITH RAT NEPHRITOGENIC ANTIGEN Yoshikazu Sado,1 Ichiro Naito,1 Takayuki Kohda,2 Masafumi Taki,3 Hiroyuki Omori.3 1Divisions of Immunology and Ultrastructural Biology, Shigei Medical Research Institute, Okayama, Japan; 2Division of Pediatrics and Perinatology, Faculty of Medicine, Tottori University, Yonago, Tottori, Japan; 3Department of Internal Medicine, Shigei Medical Research Hospital, Okayama, Japan

M112 T CELL POPULATION AND FUNCTIONS ARE ALTERED IN IDIOPATHIC MEMBRANOUS NEPHROPATHY Aki Kuroki, Masayuki Iyoda, Tetsuzo Sugisaki. Department of Nephrology, Showa University, School of Medicine, Tokyo, Japan

M113 PASSIVELY-INDUCED EXPERIMENTAL ANTI-GBM NEPHRITIS IN RATS BY VARIOUS HOMOLOGOUS MONOCLONAL ANTIBODIES: SUBCLASS-EFFECT AND DOSE-EFFECT RELATIONSHIPS Takayuki Kohda,1,2,3 Tadashi Kado,2 Shin-ichi Okada,2 Atsushi Hayashi,2 Yasushi Utsunomiya,2 Susumu Kanzaki,2 Masafumi Taki,3 Yoshikazu Sado.4 1Department of Pediatrics, Yoka Hospital, Yoka, Yoka-cho, Yabu- gun, Hyogo Prefecture, Japan; 2Division of Pediatrics and Perinatology, Faculty of Medicine, Tottori University, Yonago, Tottori Prefecture, Japan; 3Department of Internal Medicine, Shigei Medical Research Hospital, Okayama, Okayama Prefecture, Japan; 4Division of Immunology, Shigei Medical Research Institute, Okayama, Okayama Prefecture, Japan

M114 AGGRAVATION OF NEPHROTOXIC SERUM NEPHRITIS IN RATS BY COMPLETE ADJUVANT ALONE. THE ROLE OF MACROPHAGES Kazumitsu Mukai, Takanori Shibata, Kenichi Kato, Tetsuzo Sugisaki. Department of Nephrology, Showa University School of Medicine, Shinagawa-ku, Tokyo, Japan POSTERS MONDAY JUNE 9TH

M115 THE EXPRESSION OF INTEGRIN-RELATED SIGNAL TRANSDUCTION PROTEINS IN CRESCENTIC GLOMERULONEPHRITIS Tetsuya Ootaka,1 Kenji Nakayama,2 Hiroshi Sato,2 Sadayoshi Ito,2 Toshinobu Sato.3 1Dept Med Technology, Coll of Med Sciences, Tohoku Univ, Sendai, Japan; 2Div Nephrology, Hypertension and Endocrinology, Dept Int Med, Tohoku Univ School of Medicine, Sendai, Japan; 3Dept Blood Purification, Tohoku Univ School of Medicine, Sendai, Japan

M116 A MECHANISM FOR REPAIR OF CRESCENTIC GLOMERULI? Michel Le Hir, Valerie Besse-Eschmann. Institute of Anatomy, University of Zurich, Zurich, Switzerland

M117 EXPRESSION PROFILE AND POTENTIAL (PATHO- MONDAY )PHYSIOLOGICAL ROLE OF PROTEINASE 3 (WEGENER AUTOANTIGEN) IN HUMAN TISSUES Manfred Relle,1 Werner Mayet,2 Peter R. Galle,1 Andreas Schwarting.1 1I. Medical Clinic, University of Mainz, Mainz, RLP, Germany; 2Zentrum fuer Innere Medizin, Nordwest-Krankenhaus Sanderbusch, Sande, Germany

SILICA PARTICLES CAUSE NECROSIS RATHER THAN APOPTOSIS OF POLYMORPHONUCLEAR NEUTROPHILS IN VITRO. A FACTOR IN THE PATHOGENESIS OF VASCULITIS? Matthew L.P. Howse,1 Gordon M. Bell,1 Steven W. Edwards.2 1Nephrology, Royal Liverpool University Hospital, Liverpool, Merseyside, United Kingdom; 2Biological Sciences, University of Liverpool, Liverpool, Merseyside, United Kingdom

M119 ANTI-NEUTROPHIL CYTOPLASM ANTIBODIES (ANCA) ENHANCE NEUTROPHIL ADHESION AND MIGRATION ACROSS ENDOTHELIAL CELLS VIA b2 INTEGRINS, CXCR1 AND CXCR2 Judith W. Calderwood,1 Gerard B. Nash,2 Caroline O. Savage.1 1Department of Renal Immunobiology, 2Department of Physiology, University of Birmingham, Birmingham, United Kingdom

M120 TH1 VERSUS TH2 IMMUNE RESPONSE IN RENAL TISSUES OF MRL-lpr/lpr MICE Fei Li, Suo-Zhu Shi, Xiang-Mei Chen. Department of Nephrology, General Hospital of PLA, Beijing, China

M121 TARGETING STAT-4 TRANSCRIPTION FACTOR IN SEVERE LUPUS NEPHRITIS REVEALS STAGE DEPENDENT DIFFERENT PATHOPHYSIOLOGICAL EFFECTS Andreas Schwarting, Birte Kutska, Julia Menke, Manfred Relle, Sabine Kupferschmidt, Peter Galle. Department of Medicine, University of Mainz, Mainz, Germany

M122 ATORVASTATIN LEADS TO A REDUCTION IN MHC CLASS II EXPRESSION AND A FALL IN dsDNA ANTIBODY LEVELS IN THE MURINE MODEL OF LUPUS NZBWF1 Sarah H.A. Lawman, Michael R. Ehrenstein. Department of Medicine, University College London, London, United Kingdom

M123 PROTECTIVE EFFECT OF ALL-TRANS-RETINOIC ACID TREATMENT ON THE DEVELOPMENT OF LUPUS-LIKE DISEASE IN MRL/lpr MICE Guillermo Pérez de Lema,1 Javier de Lucio,2 Ana Molina,3 Bernhard Banas,1 Francisco Mampaso,3 Detlef Schlöndorff.1 1Medizinische Poliklinik, Ludwig-Maximilians-Universität, München, Germany; 2Physiology, Uni. AlcaláAlcalá de Henares, Spain; 3Pathology. Hospital Univ. Ramón y Cajal, Uni. AlcaláMadrid, Spain TH MONDAY JUNE 9 POSTERS

M124 CASPASE-1 INHIBITOR THERAPY OF SEVERE LUPUS NEPHRITIS HIGHLIGHTS THE PATHOPHYSIOLOGIC IMPACT OF IL-18 Andreas Schwarting,1 Julia Menke,1 Karl Rudolphi,2 Martin Schönharting,2 Susanne Strand,1 Dennis Strand,1 Peter Galle.1 1Ist Department of Medicine, University Hospital, Mainz, Germany; 2Aventis Pharma, Frankfurt, Germany

M125 THE IMMUNOREACTIVITY OF GLIAL FIBRILLARY ACIDIC PROTEIN (GFAP) IN THE GLOMERULI OF RAT KIDNEY Alexander Kuhlmann,1 Udo Reulbach,2 Christian-Stefan Haas,3 Marie-Luise Gross,4 Kerstin Amann.1 1Department of Pathology, University of Erlangen, Erlangen, Bavaria, Germany; 2Department of Medical Informatics, Biometry and Epidemiology, University of Erlangen, Erlangen, Bavaria, Germany; 3Department of Pathology, Northwestern University, Chicago, IL, United States; 4Department of Pathology, University of Heidelberg, Heidelberg, Baden-Wuerttemberg, Germany; 5Department of Pathology, University of Erlangen, Erlangen, Bavaria, Germany

M126 BINDING OF THE CHEMOKINE SLC/CCL21 TO ITS RECEPTOR CCR7 INCREASES ADHESIVE PROPERTIES OF HUMAN MESANGIAL CELLS Bernhard Banas, Markus Wornle, Mercedes Gonzales-Rubio, Sabine Sauer, Holger Schmid, Matthias Kretzler, Guillermo Perez de Lema, Detlef Schlondorff. Medizinische Poliklinik, University of Munich, Munich, Germany

M127 THE ROLE OF INTERFERON-INDUCIBLE PROTEIN (IP-10) ON PAN NEPHROPATHY Gi Dong Han, Hiroko Koike, Takeshi Nakatsue, Fujio Shimizu, Hiroshi Kawachi. Cell Biology, Nephrology, Niigata, Japan

M128 CRUCIAL ROLE OF GENETIC BACKGROUND FOR THE DEVELOPMENT OF GLOMERULONEPHRITIS IN A 6-19 RHEUMATOID FACTOR TRANSGENIC MOUSE MODEL Shuichi Kikuchi,1,3 Liliane Fossati-Jimack,1 Aki Kuroki,1 Haruyoshi Yoshida,2 Akio Koyama,3 Shozo Izui.1 1Department of Pathology, University of Geneva, Geneva, Switzerland; 2Department of Clinical Laboratory Medicine and Nephrology, Fukui Medical University, Fukui, Japan; 3Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan

M129 GRANULOMATOUS TUBULOINTERSTITIAL NEPHRITIS INDUCED BY SENSITIZATION OF NON-COLLAGENOUS DOMAINS OF GLOMERULAR BASEMENT MEMBRANE (GBM) IN MONKEYS Hidekazu Shigematsu,1 Masatoshi Yamamoto,2 Yoh-ichi Tazawa,2 Tsukao Yokoyama.3 1Department of Pathology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan; 2Division of Pathology, Ina Research Inc., Ina, Nagano, Japan; 3Collagen Research Center, Shizuoka, Japan

M130 ISOLATION, LOCALIZATION AND CHARACTERIZATION OF RODENT KIDNEY DENDRITIC CELLS Thilo Krüger, Dirk Benke, Andreas Lang, Monika Wirtz, Emma E. Hamilton-Williams, Frank Eitner, Christian Kurts. Medizinische Klinik II, Universitätsklinikum Aachen, Aachen, Nordrhein-Westfalen, Germany POSTERS MONDAY JUNE 9TH

M131 THROMBIN INDUCES p38 MAP KINASE ACTIVATION AND IL- 12 GENE EXPRESSION IN MONOCYTE-DERIVED DENDRITIC CELLS (DC) P. Pontrelli,1 G. Grandaliano,1 E. Ranieri,1 A. Blasi,1 L. Roca,1 F.P. Schena,1 L. Gesualdo.2 1Div. of Nephrology, DETO, University of Bari, Italy; 2Chair of Nephrology, University of Foggia, Italy

M132 MECHANISMS OF PMN TRANSMIGRATION ACROSS HUMAN RENAL EPITHELIAL MONOLAYERS Daniel H. Sturn, Nicole C. Kaneider, Christian J. Wiedermann, Michael Joannidis. Internal Medicine, University of Innsbruck, Innsbruck, Tyrol, Austria

M133 NEURAL CELL ADHESION MOLECULE (NCAM) POSITIVE MONDAY RENAL INTERSTITIAL CELLS Jasmina Markovic-Lipkovski,1 Claudia A. Müller,2 Gerd Klein,2 Thomas Flad,2 Tatyana Klatt, 2 Susanne Widmann, 2 Hans Wessels, 3 Sabine Blaschke, 3 Gerhard A. Müller.3 1Institute of Pathology, Medical School, University of Belgrade, Belgrade, , Yugoslavia; 2University Medical Clinic, Eberhard- Karls University of Tübingen, Tübingen, Germany; 3Center of Internal Medicine, Georg-August University of Göttingen, Göttin

M134 THE PROTEASE INHIBITOR 9 IS EXPRESSED BY TUBULAR EPITHELIAL CELLS IN VIVO AFTER RENAL ISCHEMIA- REPERFUSION IN MICE Sandrine Florquin,1 Kasper Rouschop,1 Nike Claessen,1 Inge Hoedemaker,1 J. Alain Kummer,2 Jan Weening,1 C. Erik Hack.3 1Pathology, Academic Medical Center, Amsterdam, Netherlands; 2Pathology, Free University Medical Cluster, Amsterdam, Netherlands; 3Immunopathology, Sanquin Research, Amsterdam, Netherlands

M135 IN VITRO EFFECTS OF TAMM-HORSFALL PROTEIN ON POLYMORPHONUCLEAR LEUKOCYTE FUNCTIONS Thomas Wimmer, Gerald Cohen, Walter H. Hörl. Division of Nephrology, Department of Medicine III, University of Vienna, Vienna, Austria

M136 CARBOXY-TERMINAL TRUNCATED RETINOL BINDING PROTEIN FROM ARF PATIENTS INHIBITS ESSENTIAL FUNCTIONS OF POLYMORPHONUCLEAR LEUKOCYTES Gerald Cohen, Walter H. Hörl. Division of Nephrology, Department of Medicine III, University of Vienna, Vienna, Austria

M137 LOCAL SYNTHESIS OF C3 STIMULATES TRANSMIGRATION OF ALLOREACTIVE T CELLS ACROSS TUBULAR EPITHELIAL CELLS Shamim Basheer, Julian Pratt, Steven Sacks. Nephrology & Transplantation, King’s College, University of London, London, United Kingdom

M138 INCREASE IN TH1 AND TH2 CYTOKINE PRODUCTION BY BLOCKADE OF THE B7RP-1/ICOS PATHWAY IN RENAL TUBULAR EPITHELIAL CELLS Patricia R. Wahl,1 Thomas P. Horan,2 Steven K. Yoshinaga,2 Rudolf P. Wüthrich.1 1Division of Nephrology, Kantonsspital, St. Gallen, Switzerland; 2Amgen Inc., Thousand Oaks, CA, United States

M139 INDEPENDENT PATHWAYS OF P-SELECTIN AND COMPLEMENT- MEDIATED RENAL ISCHEMIA REPERFUSION INJURY Conrad A. Farrar, Wuding Zhou, Steven H. Sacks. Dept. of Nephrology & Transplantation, Guy’s Hospital, London, United Kingdom TH MONDAY JUNE 9 POSTERS

M140 COMPLEMENT-MEDIATED INTERNALISATION OF HUMAN URINARY PATHOGENS: AN ACTIVE TWO STEP PROCESS Neil Sheerin, Ki Li, Steven Sacks. Department of Nephrolgy and Transplantation, Guy’s Hospital, King’s College London, London, United Kingdom

M141 IDENTIFICATION AND CLONAL EXPANSION OF AUTOLOGOUS TUMOR-SPECIFIC CD8+ CYTOTOXIC T LYMPHOCYTES IN CLEAR RENAL CELL CARCINOMA (RCC) C. Di Natale,1 W. Herr,2 M. Cellie,1 A. Loverre,1 G. Cerullo,1 S. Lanzilotta,1 V. Mancini,3 P. Ditonno,3 M. Battaglia,3 F.P. Selvaggi,3 W.J. Storkus,4 F.P. Schena,1 L. Gesualdo,5 E. Ranieri.1 1D.E.T.O., Section of Nephrology, University of Bari, Italy; 2Dept. of Hämatologie und Onkologie, Universität Mainz, Germany; 3D.E.T.O., Section of Surgical Nephrology, University of Bari, Italy; 4Dept. of Surgery, University of Pittsburgh, PA, United Sta POSTERS MONDAY JUNE 9TH

PATHOPHYSIOLOGY OF DIABETES MELLITUS AND DIABETIC COMPLICATIONS

M142 MICROARRAY EXPRESSION ANALYSIS OF MESANGIAL CELLS OVEREXPRESSING GLUCOSE TRANSPORTERS: MARKED INCREASE IN INTERLEUKIN-6 PRODUCTION Cora Weigert,1 Albrecht Pfaefflin,1 Katrin Brodbeck,1 Charles W. Heilig,2 Hans Ulrich Haering,1 Erwin D. Schleicher.1 1Department of Internal Medicine, University of Tuebingen, Tuebingen, Germany; 2III Division of Nephrologie, Johns Hopkins School of Medicine, Baltimore, MD, United States MONDAY M143 DIFFERENT GLOMERULAR EXPRESSION OF PROTEIN KINASE C (PKC) ISOFORMS IN DIABETIC NEPHROPATHY: COMPARISON WITH IgA NEPHROPATHY Toshihiko Machiguchi,1 Hideki Kimura,1 Satomi Yonemoto,2 Noriyo Kimura,1 Xuan Li,1 Haruyoshi Yoshida.1 1Department of Clinical Laboratory Medicine & Nephrology, Fukui Medical University, Matsuoka, Fukui, Japan; 2Division of Nephrology, MRI Kitano Hospital, Osaka, Japan

M144 DIFFERENTIAL EXPRESSION OF RENAL PROTEIN KINASE C ISOFORMS AND a-TUBULIN IN A MODEL OF DIABETES AND HYPERTENSION Tanya Osicka,1 Leileata Russo,2 Mei-Lan Qiu,1 Vicki Thallas,3 Josephine Forbes,3 Wayne Comper,2 George Jerums.1 1Endocrine Unit, Austin & Repatriation Medical Centre, Heidelberg, Victoria, Australia; 2Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia; 3Diabetes, Metabolism, Lipoproteins, Baker Medical Research Institute, Prahran, Victoria, Australia

M145 PROTEIN KINASE C ALPHA IS INVOLVED IN THE DEVELOPMENT OF ALBUMINURIA BY REGULATION OF HEPARAN SULFATE SYNTHESIS Jan Menne,1 Joon-Keun Park,2 Martin Boehne,2 Marlies Elger,2 Ina Klebba,1 Carsten Lindschau,2 Faikah Gueler,2 Michael Leitges,3 Hermann Haller.2 1Nephrology, Phenos GmbH, Hannover, Germany; 2Dep. of Nephrology, Medical School Hannover, Hannover, Germany; 3MPI for Experimental Endocrinology, Hannover, Germany

M146 RENOPROTECTIVE EFFECT OF GLICLAZIDE BY RADICAL SCAVENGE IN DIABETIC RAT WITH HIGH CHOLESTEROL DIET Akihiro Tojo, Maristela Lika Onozato, Atsuo Goto, Toshiro Fujita. Division of Nephrology and Endocrinology, The University of Tokyo, Tokyo, Japan

M147 COMPARISON OF SOD MIMETIC AND NADPH OXIDASE INHIBITOR IN DIABETIC NEPHROPATHY Kensuke Asaba, Akihiro Tojo, Maristela Lika Onozato, Atsuo Goto, Toshiro Fujita. Division of Nephrology and Endocrinology, University of Tokyo, Tokyo, Japan

M148 IMPROVEMENT OF ANTIOXIDANT DEFENSE IN THE OBESE ZUCKER RAT KIDNEY FOLLOWING LOW-DOSE ANGIOTENSIN I CONVERTING ENZYME INHIBITOR / DIURETIC LONG-TERM TREATMENT Isabelle M. Renaud,1,2 Marc Conti,3 Odile Michel,1 Isaac Myara,1 Gerard E. Plante,2 Jacques Chevalier.1 1INSERM U430, Broussais Hospital, Paris, France; 2Pharmacology Institute, Sherbrooke University, Sherbrooke, QC, Canada; 3Biochemistry Department, Bicetre Hospital, Le Kremlin Bicetre, France TH MONDAY JUNE 9 POSTERS

M149 OXIDATIVE STRESS, METALLOPROTEASE AND VASOPEPTIDASE INTERPLAY IN A NEW RAT MODEL OF TYPE 2 DIABETIC RENAL FIBROSIS INITIATION Philippe Zaoui,1 Nicole Pinel,1 Eliane Rossini,1 Darren Kelly,2 Allisson Cox,2 Richard Gilbert,2 Francoise Morel,1 Daniel Cordonnier.1 1Nephrologie, Pathologie Cellulaire, GREPI, CHU Grenoble, Grenoble, France; 2Medicine, St Vincent Hospital, Fitzroy, Victoria, Australia

M150 ADVANCED GLYCATION END PRODUCTS ACTIVATE TGF-b SIGNALING PATHWAY THROUGH RAGE-MEDIATED ROS GENERATION AND THE SUBSEQUENT ANGIOTENSIN II PRODUCTION IN CULTURED MESANGIAL CELLS Kei Fukami,1 Seiji Ueda,1 Sho-ichi Yamagishi,2 Seiya Kato,3 Kiyoshi Tamaki,1 Seiya Okuda.1 1Department of Nephrology, Kurume University School of Medicine, Kurume, Fukuoka, Japan; 2Department of Endocrinology and Metabolism, Kurume University School of Medicine, Kurume, Fukuoka, Japan; 3Department of Pathology, Kurume University School of Medicine, Kurume, Fukuoka, Japan

M151 ADVANCED GLYCATION END PRODUCTS STIMULATE HUMAN ENDOTHELIAL CELLS TO PRODUCE MONOCYTE CHEMOATTRACTANT PROTEIN-1 Xun Zhang, Zhijian Guo, Min Liang, Fan Fan Hou. Division of Nephrology, Nanfang Hospital, Guangzhou, GuangDong, China

M152 EFFECT OF ADVANCED GLYCATION END PRODUCTS ON GENE EXPRESSION AND SYNTHESIS OF TNF-a BY ENDOTHELIAL CELLS Gloria Rashid,1 Sydney Benchetrit,1,2 Jacques Bernheim.1,2 1Nephrology and Hypertension, Sapir Medical Center, Kfar-Saba, Israel; 2Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel

M153 EFFECT OF ADVANCED GLYCATION END PRODUCTS ON eNOS AND iNOS GENE EXPRESSION BY ENDOTHELIAL CELLS Gloria Rashid,1 Sydney Benchetrit,1,2 Jacques Bernheim.1,2 1Nephrology and Hypertension, Sapir Medical Center, Kfar-Saba, Israel; 2Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel

M154 ALT-711, AN “AGE CROSS-LINK BREAKER “, AMELIORATES RENAL INJURY IN db/db MICE Min Kyung Kwon,1 Hunjoo Ha,1 Wan Young Kim,2 Jin Kim,2 Ryoji Nagai,3 Seikoh Horiuchi,3 Hi Bahl Lee.1 1Hyonam Kidney Laboratory, Soon Chun Hyang University, Seoul, Korea; 2Department of Anatomy, College of Medicine, The Catholic University, Seoul, Korea; 3Kumamoto University School of Medicine, Kumamoto, Japan

M155 THE ROLE OF ADVANCED GLYCATION END PRODUCTS IN MEDIATING RENAL INJURY IN THE DIABETIC APO E KNOCKOUT MOUSE Karin Jandeleit-Dahm, Lot de Witte, Kwee Seah, Markus Lassila, Riccardo Candido, Merlin Thomas, Terri Allen, Mark Cooper. Danielle Alberti Centre for Diabetic Complications, Vascular Division, Baker Medical Research Institute, Melbourne, VIC, Australia

M156 NITRIC OXIDE (NO)-DEPENDENT RENAL VASODILATION IS UNCOUPLED FROM CYCLIC GMP IN TYPE 1-DIABETIC RATS Axel Pflueger, Karl Nath. Division of Nephrology, Mayo Clinic and Foundation, Rochester, MN, United States POSTERS MONDAY JUNE 9TH

M157 INSULIN STIMULATES INDUCIBLE NITRIC OXIDE SYNTHESIS IN NORMAL HUMAN MESANGIAL CELLS BY AUGMENTING CELLULAR UPAKE OF L-ARGININE Sharma Prabhakar. Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, United States

M158 SELECTIVE COLOCALISATION OF RENIN AND IMIDAZOLONE IN THE PERITUBULAR CAPILLARY ENDOTHELIUM OF DIABETIC RATS Peter Degrell,1 Toshimitsu Niwa,2 Zoltan Wagner,1 Balazs Lukats,3 Gergo A. Molnar,1 Laszlo Wagner,1 Zoltan Karadi,3 Judit Nagy,1 Istvan Wittmann.1 1Second Department of Medicine and Nephrological Center, Faculty of Medicine, University of Pecs, Pecs, Hungary; 2Department of MONDAY Clinical Preventive Medicine, Nagoya University, Daiko Medical Center, Nagoya, Japan; 3Institute of Physiology, Faculty of Medicine, University of Pecs, Pecs, Hungary

M159 SUPPRESSED ANGIOTENSIN CONVERTING ENZYME (ACE) EXPRESSION IN RENAL CORTEX FROM THE DIABETIC db/db MICE Minghao Ye,1 Jan Wysocki,1 Parveen Naaz,1 M. Reza Salabat,1 Daniel Batlle.1,2 1Division of Nephrology, Feinberg School of Medicine, Northwestern University; 2VA Lakeside Medical Center, Chicago, IL, United States

M160 IRBESARTAN INHIBITIS NUCLEAR FACTOR-KAPPA B ACTIVATION IN THE KIDNEY WITH TYPE 2 DIABETES Ping Gao, Ruhan Jia, Xueyu Wang. Division of Nephrology, Renmin Hospital of Wuhan University, Wuhan City, Hubei Province, China

M161 ANGIOTENSIN CONVERTING ENZYME INHIBITION DOES NOT ATTENUATE CONNECTIVE TISSUE GROWTH FACTOR OVER- EXPRESSION IN HUMAN OR RODENT DIABETIC NEPHROPATHY Robyn Langham,1 Darren Kelly,1 Alison Cox,1 Philippe Zaoui,2 Nicole Pinel,2 Daniel Cordonnier,2 Richard Gilbert.1 1University of Melbourne Department of Medicine, St. Vincent’s Hospital, Fitzroy, VIC, Australia; 2Centre Hospitaliare, Universitaire de Grenoble, Grenoble, France

M162 SIMVASTATIN MODULATES ANGIOTENSIN II SIGNALING IN DIABETIC MILIEU Ramon Anel,1 Lixia Zeng,1 Shubhada Ahya,1 Jay Paparello,1 Christian S. Haas,2 Yashpal S. Kanwar,2 Farhed R. Danesh.1 1Department of Medicine, Northwestern University, Chicago, IL, United States; 2Department of Pathology, Northwestern University, Chicago, IL, United States

M163 HIGH GLUCOSE STIMULATES ANGIOTENSINOGEN (ANG) GENE EXPRESSION AND CELL HYPERTROPHY VIA ACTIVATION OF HEXOSAMINE BIOSYNTHETIC PATHWAY (HBP) IN RAT KIDNEY PROXIMAL TUBULAR CELLS John S.D. Chan,1 Tusty-Juian Hsieh,1 Pierre Fustier,1 Shao-Ling Zhang,1 Janos G. Filep,1 Shiow-Shih Tang,2 Julie R. Ingelfinger,2 Ivan G. Fantus,3 Pavel Hamet.1 1Res. Center, CHUM-Hotel Dieu, Montreal, QC, Canada; 2Pediatr Nephrol Unit, Mass. Gen. Hosp., Boston, MA, United States; 3Medicine, Mount Sinai Hosp., Toronto, ON, Canada TH MONDAY JUNE 9 POSTERS

M164 INTRARENAL RENIN-ANGIOTENSIN SYSTEM (RAS) ACTIVATION INDUCES INSULIN RESISTANCE ON ANGIOTENSINOGEN (ANG) GENE EXPRESSION IN RAT KIDNEY PROXIMAL TUBULAR CELLS IN HIGH GLUCOSE John S.D. Chan,1 Tusty-Jiuan Hsieh,1 Pierre Fustier,1 Shao-Ling Zhang,1 Janos G. Filep,1 Shiow-Shih Tang,2 Julie R. Ingelfinger,2 Serge Carriere,3 Hamet Pavel.1 1Res. Center, CHUM-Hotel Dieu, Montreal, QC, Canada; 2Pediatr Nephrol Unit, Mass. Gen. Hosp., Boston, MA, United States; 3Res. and Develop., Servier Canada, Laval, QC, Canada

M165 INTERSTITIAL INFLAMMATION AND RENIN-ANGIOTENSIN SYSTEM (RAS) ACTIVATION IN HUMAN DIABETIC NEPHROPATHY Sergio Mezzano,1 M. Eugenia Burgos,1 Alejandra Droguett,1 Leopoldo Ardiles,1 Claudio Aros,1 Claudio Flores,1 Carlos Vío,2 Marta Ruiz-Ortega,3 Jesús Egido.3 1Division Nephrology, Universidad Austral, Valdivia, Chile; 2Ciencias Biológicas, Universidad Católica, Santiago, Chile; 3Fundación Jiménez-Díaz, Universidad Autónoma, Madrid, Spain

M166 RENOPROTECTIVE EFFECTS OF LONG-TERM ADMINISTRATION OF A LOW-DOSE ANGIOTENSIN I CONVERTING ENZYME INHIBITOR / DIURETIC PREPARATION IN THE OBESE ZUCKER RAT Isabelle M. Renaud,1,2 Angele Chainey,2 Jacques Chevalier,1 Gerard E. Plante.2 1INSERM U430, Broussais Hospital, Paris, France; 2Pharmacology Institute, Sherbrooke University, Sherbrooke, QC, Canada

M167 DOPAMINE D3 RECEPTOR BLOCKADE INFLUENCES RENAL FUNCTION AND GLOMERULAR SIZE IN DIABETIC RATS Gerd Luippold,1 Martina Beilharz,1 Liliane Unger,2 Gerhard Gross,2 Bernd Mühlbauer.1 1Dept. of Pharmacology and Toxicology, University of Tübingen, Tübingen, Germany; 2CNS Research, Abbott GmbH&Co.KG, Ludwigshafen, Germany

M168 INCREASED EXPRESSION OF ENDOTHELIN-1 IN TYPE I DIABETIC NEPHROPATHY IS MEDIATED BY F2 ISOPROSTANES Angel Montero, Susheng Wang. Renal Division, Emory University and Atlanta VAMC, Atlanta, GA, United States

M168a COMPARISON OF THE RENOPROTECTIVE EFFECT OF AN ENDOTHELIN RECEPTORBLOCKER AND AN ACE INHIBITOR IN A MODEL OF DIABETIC NEPHROPATHY Marie-Luise Gross,1 Eberhard Ritz,2 Arne Schoof,1 Orien Tulp,3 Kerstin Amann.4 1Dept. of Pathology, University of Heidelberg, Heidelberg, Germany; 2Dept. of Internal Medicine, University of Heidelberg, Heidelberg, Germany; 3London College of Medicine, London, Germany; 4Dept. of Pathology, University of Erlangen, Erlangen, Germany

M169 DECREASED GLOMERULAR SYNTHESIS OF ADRENOMEDULLIN IN PATIENTS WITH DIABETIC NEPHROPATHY Hung-Chun Chen, Jinn-Yuh Guh, Shyi-Jang Shin, Yung-Hsiung Lai. Department of Internal Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

M170 THE LACK OF CYCLIN KINASE INHIBITOR p27KIP1 AMELIORATES PROGRESSION OF DIABETIC NEPHROPATHY Midori Awazu, Sayu Omori, Mariko Hida, Hisayo Fujita. Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan POSTERS MONDAY JUNE 9TH

M171 HYPERGLYCAEMIA-INDUCED KIDNEY MACROPHAGE ACCUMULATION CORRELATES WITH RENAL INJURY IN TYPE 2 DIABETIC DB/DB MICE Fiona Chow,1,2 Elyce Ozols,1,2 Robert Atkins,1,2 Gregory Tesch.1,2 1Department of Nephrology, Monash Medical Centre, 2Department of Medicine, Monash University, Monash Medical Centre, Clayton, Victoria, Australia

M172 GROWTH ARREST-SPECIFIC GENE 6 PLAYS AN IMPORTANT ROLE IN THE DEVELOPMENT OF GLOMERULAR HYPERTROPHY IN THE EARLY PHASE OF DIABETIC NEPHROPATHY Kojiro Nagai,1 Hidenori Arai,1 Motoko Yanagita,1 Takeshi Matsubara,1 Akira Mima,1 Hiroshi Kanamori,1 Eriko Sumi,1 Noriyuki Iehara,3 Atsushi Fukatsu,3 Toru Kita,2 Toshio Doi.4 MONDAY 1Geriatric Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan; 2Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan; 3Artificial Kidneys, Kyoto University, Kyoto, Japan; 4Clinical Biology and Medicine, Tokushima University, Tokushima, Japan

M173 METABOLIC PROFILE AND RENAL HEMODYNAMICS IN RATS SUBJECTED TO PRE-NATAL MALNUTRITION AND A HIGH GLUCOSE DIET DURING ADULT LIFE Ana C.R.D. Saturnino,1,3 Adriana C.C. Argolo,1 Ralfo C. Medeiros,3 Jorge A.L. Rodríguez,3 Valéria C.R. Dantas,3 Luana C.B.B. Coelho,1 Ana D.O. Paixão.2 1Department of Biochemistry, Federal University of Pernambuco, Recife, PE, Brazil; 2Department of Physiology and Pharmacology, Federal University of Pernambuco, Recife, PE, Brazil; 3Department of Pharmacy, Federal University of Rio Grande do Norte, Natal, RN, Brazil

M174 THE ENZYME COX-2 MEDIATES A SHIFT IN RENAL PROSTAGLANDIN BALANCE TOWARDS GREATER TXA2 ACTIVITY IN MICE PRONE TO AUTOIMMUNE DIABETES Vikas Dharnidharka, Edward Paek, Michael Clare-Salzler. Pediatrics/Pathology, University of Florida, Gainesville, FL, United States

M175 THE SPECIFIC TP RECEPTOR ANTAGONIST S 18886 AMELIORATES DIABETIC NEPHROPATHY (DN) AND OXIDATIVE STATUS IN UNINEPHRECTOMIZED OBESE ZUCKER RATS K. Sebekova,1 T. Eifert,2 K. Tyralla,2 K. Amann,2 A. Heidland.3 1OEAB, Inst. Prev. Clin. Medicine, Bratislava, Slovakia (Slovak Republic); 2Dept. Pathology, Univ., Erlangen, Germany; 3Dept. Int. Med., Univ., Wuerzburg, Germany

M176 RENAL DISEASE IN THE METABOLIC SYNDROME AND ANTI- LOX THERAPY Jesus Dominguez,1 Richard Peterson,2 Subah Packer,3 Connie Temm.1 1Medicine, IUMC & VAMC, Indianpolis, IN, United States; 2Anatomy, IUMC, Indianapolis, IN, United States; 3Physiology, IUMC, Indianapolis, IN, United States

M177 EARLY CHANGES IN GLOMERULAR CHARGE SELECTIVITY IN STREPTOZOTOCIN DIABETIC RATS Bengt Rippe,1 Ole Torffvit,2 Anna Rippe,1 Olav Tenstad,3 Bert-Inge Rosengren.1 1Department of Nephrology, University Hospital of Lund, Lund, Sweden; 2Department of Medicine, University Hospital of Lund, Lund, Sweden; 3Department of Physiology, University of Bergen, Bergen, Norway TH MONDAY JUNE 9 POSTERS

M178 INCREASED EXPRESSION OF S-ADENOSYLHOMOCYSTEINE- HYDROLASE IN THE KIDNEY OF RATS WITH EXPERIMENTAL INSULIN-DEPENDENT DIABETES MELLITUS Doris Kloor, Marina Hermes, Timo Rieg, Renate Riehle, Hartmut Osswald. Dept. of Pharmacology and Toxicology, Faculty of Medicine, University of Tuebingen, Tuebingen, Germany

M179 HYPERTENSION ACCELERATES DIABETIC NEPHROPATHY IN WISTAR FATTY RATS, A MODEL OF TYPE 2 DIABETES MELLITUS, VIA MAP KINASE CASCADES AND TGF-b Takeo Satoh,1 Goro Imai,1 Toshio Kumai,2 Hiroki Tsuchida,1 Yoshinori Shima,1 Mei Murao,1 Giichi Ogimoto,1 Kenjiro Kimura.1 1Internal of Medicine, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan; 2Pharmacology, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan

M180 INCREASED RENAL EXPRESSION OF PARATHYROID HORMONE-RELATED PROTEIN AND THE PTH/PTHrP TYPE 1 RECEPTOR IN STREPTOZOTOCIN-INDUCED DIABETES Adriana Izquierdo,1 Pilar López-Luna,1 Arantxa Ortega,2 M. Antonia Gutiérrez-Tarrés,1 J. José Granizo,2 Jordi Bover,3 Pedro Esbrit,2 Ricardo J. Bosch.1 1Physiology, Alcalá University, Alcalá de Henares, Madrid, Spain; 2Research Unit, Fundación Jiménez Díaz, Madrid, Spain; 3Nephrology, Fundació Puigvert, Barcelona, Spain

M181 PODOCALYXIN-MATRIX INTERACTIONS: THE ROLE OF HUMAN GLOMERULAR EPITHELIAL CELL SURFACE- ASSOCIATED SIALOPROTEIN PODOCALYXIN IN FOOT PROCESS FORMATION-CHANGES IN DIABETIC CONDITIONS Constantinos Economou,1 Paraskevi Kitsiou,1 David Kershaw,2 Vicky Panagopoulou,3 Evaggelos Marinos,3 Effie Tsilibary.1 1Institute of Biology, National Center for Scientific Research Demokritos, Agia Paraskevi, Attiki, Greece; 2Department of Pediatrics, University of Michigan, Ann Arbor, MI, United States; 3Department of Histology, Medical School, Athens University, Goudi, Attiki, Greece

M182 ROLE OF STORE OPERATED CALCIUM CHANNELS (SOC) IN MESANGIAL CELL PROLIFERATION ASSOCIATED WITH MODELS OF TYPE 2 DIABETES MELLITUS Peilin Wei, Xiaoxia Wang, Jennifer Pluznick, Emilie Mercier, Babu Padanilam, Steve Sansom. Physiology and Biophysics, University of Nebraska Medical Center, Omaha, NE, United States

M183 LONG-TERM RENAL CHANGES IN THE GOTO-KAKIZAKI RAT, A MODEL OF LEAN TYPE 2 DIABETES Bieke F Schrijvers,1,2 An S. De Vriese,2 Johan Van de Voorde,3 Ruth Rasch,4 Norbert H. Lameire,2 Allan Flyvbjerg.1 1Medical Research Laboratories, Institute of Experimental Clinical Research, Aarhus University Hospital, Aarhus, Denmark; 2Renal Unit, Ghent University Hospital, Ghent, Belgium; 3Department of Physiology and Physiopathology, Ghent University, Ghent, Belgium; 4Department of Cell Biology, Institute of Anatomy, Aarhus University, Aarhus, Denmark POSTERS MONDAY JUNE 9TH

PRIMARY GLOMERULAR DISEASES: CLINICAL

M184 ANALYSIS OF CYTOKINE-GENE EXPRESSION PROFILES IN CHILDHOOD MINIMAL CHANGE NEPHROTIC SYNDROME USING cDNA ARRAY Motoshi Hattori,1 Hiroko Chikamoto,1 Sanpei Miyakawa,1 Ken Tsuchiya,2 Katsumi Ito.1 1Pediatric Nephrology, Tokyo Women’s Medical Universiy, Shinjuku, Tokyo, Japan; 2Medicine 4, Tokyo Women’s Medical Universiy, Shinjuku, Tokyo, Japan

M185 EOSINOPHIL CATIONIC PROTEIN (ECP) AND SKIN PRICK TESTS MONDAY IN CHILDREN WITH STEROID SENSITIVE NEPHROTIC SYNDROME (SSNS) Ashraf Bakr,1 Tarek Dosoky,1 Gehan Fathy,2 Mohamed Atwa,1 Magdy Zedan,1 Manal Fathy,3 Zakaraia El-Khaiat.2 1Pediatrics, Mansoura University Children’s Hospital, Mansoura, Dakahlia, Egypt; 2Pediatrics, Scientific Research Acadamy, Cairo, Egypt; 3Pediatrics, Ophthalmic Researc Centre, Cairo, Egypt

M186 THE ASSESSMENT OF MORPHOLOGICAL PARAMETERS AND FUNCTION OF PLATELETS IN CHILDREN WITH NEPHROTIC SYNDROME Zoch-Zwierz Walentyna, Wasilewska Anna, Tomaszewska Barbara, Wiercinski Ryszard, Biernacka Anna. 1st Department of Paediatrics, Medical University in Bialystok, Bialystok, Poland

M187 ASSOCIATION ANALYSES OF GLUCOCORTICOID RECEPTOR GENE POLYMORPHISMS WITH STEROID-RESISTANT IN IDIOPATHIC NEPHROTIC SYNDROME OF CHILDREN Jianwei Ye,1 Jie Ding,1 Jianping Huang,1 Yan Chen,1 Ying Shen,2 Qun Meng,2 Yong Yao,1 Huijie Xiao,1 Jiyun Yang.1 1Pediatrics Department, Peking University First Hospital, Beijing, China; 2Pediatrics Department, Children’s Hospital of Beijing, Beijing, China

M188 IL4, IL 8, IL 10 AND IL 18 m-RNA EXPRESSION IN PERIPHERAL BLOOD MONONUCLEAR CELLS ARE UP-REGULATED IN ACTIVE PHASE MINIMAL CHANGE NEPHROTIC SYNDROME PATIENTS Mitsuaki Kaizuka,1 Hideaki Yamabe,2 Hiroshi Osawa,2 Masayuki Nakamura,2 Yasuhiro Fujino,1 Ken Okumura.2 1Cardiology Department, Aomori Prefecture Central Hospital, Aomori, Japan; 2Second Department of Internal Medicine, Hirosaki University, Hirosaki, Japan

M189 COMPREHENSIVE GENE EXPRESSION PROFILING ANALYSIS IN MINIMAL CHANGE NEPHROTIC SYNDROME (MCNS) USING A cDNA ARRAY Yoshinari Yasuda,1 Akeyo Horie,1 Hiroko Odani,1 Shigeru Nakai,1 Satoshi Sugiyama,2 Yoshiyuki Hiki.1 1Department of In-Home Medicine, Nagoya University School of Medicine, Nagoya, Aichi, Japan; 2Department of Nephrology, School of Medicine, Fujita Health University, Toyoake, Aichi, Japan

M190 DOES PLASMA LEPTIN LEVEL CHANGE DURING THE TREATMENT WITH CORTICOSTEROIDS IN THE PATIENTS WITH NEPHROTIC SYNDROME? Romana Rysavá,1 Miroslav Merta,1 Vera Certíková,1 Tomás Zima,2 Vladimír Tesar.1 1First Medical Department, 2Department of Clinical Biochemistry, First Medical Faculty, Charles University, Prague, Czech Republic TH MONDAY JUNE 9 POSTERS

M191 A STUDY OF TUBULAR DYSFUNCTION IN IDIOPATHIC NEPHROTIC SYNDROME Vinay Malhotra,1 Jai Prakash.2 1Department of Nephrology, S.M.S Medical College & Hospital, Jaipur, Rajasthan, India; 2Department of Nephrology, Institute of Medical Sciences, Varanasi, UP, India

M192 ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH NEPHROTIC SYNDROME Apostolos Papadogiannakis,1 Dimitris Xydakis,1 Maria Sfakianaki,2 Konstantinos Kostakis,1 Nikolaos Charoulakis,3 Konstantinos Papachristoforou.1 1Nephrology Department, 2Second Internal Medicine Department, 3Radiology Department, Venizeleio Hospital, Irakleio, Crete, Greece

M193 ELEVATED URINARY NAG, TGFb AND MCP-1 EXCRETIONS DURING IMMUNOSUPPRESSIVE TREATMENT OF PATIENTS WITH NEPHROTIC SYNDROME ARE PREDICTORS OF POOR THERAPEUTIC RESPONSE Ilona Idasiak-Piechocka, Katarzyna Lochynska, Elzbieta Pawliczak, Andrzej Oko, Krzysztof Pawlaczyk, Stanislaw Czekalski. Department of Nephrology, University of Medical Sciences in Poznan, Poznan, Poland

M194 PRIMARY NEPHROTIC SYNDROME IN CHILDREN: WHAT ARE THE PREDICTORS? Fatemeh Emamghorashi,1 Noori Akhtar-Danesh,2 Elham Taghdirian.1 1Pediatric, Jahrom Medical School, Jahrom, Fars, Iran; 2Health, Jahrom Medical School, Jahrom, Fars, Iran

M195 ADOLESCENT ONSET NEPHROTIC SYNDROME IN INDIA: CLINICAL FEATURES AND HISTOPATHOLOGICAL SPECTRUM K. Sud,1 N. Sajith,1 H.S. Kohli,1 K.L. Gupta,1 K. Joshi,2 V. Sakhuja.1 1Department of Nephrology, Postgraduate Institute of Medical Education & Research, Chandigarh, UT, India; 2Department of Pathology, Postgraduate Institute of Medical Education & Research, Chandigarh, UT, India

M196 EXPRESSION OF GLUCOCORTICOID RECEPTORS IN CELLS OF PERIPHERAL BLOOD IN CHILDREN WITH NEPHROTIC SYNDROME Anna Wasilewska, Walentyna Zoch - Zwierz, Barbara Tomaszewska, Ryszard Wiercinski. First Department of Paediatrics, Medical University in Bialystok, Bialystok, Poland

M197 EFFECTS OF 3 MONTHS FLUVASTATIN TREATMENT ON LIPID METABOLISM AND PROTEIURIA IN PATIENTS WITH NEPHROTIC SYNDROME Mila Ljubomirova, Emil Andreev, Rumyana Krasteva, Regina Djerassi, Boryana Kiperova. Clinic of Nephrology, University Hospital “Alexandrovska” Sofia,

M198 A NEW THERAPEUTIC APPROACH OF STEROID- AND CYCLOPHOSPHAMIDE- RESISTANT ADULT NEPHROTIC SYNDROME Chang-Ying Xing,1 Yao-Liang Feng,2 Jia Liu,1 Xaio-Yun Wang.1 1Department of Nephrology, Jiangsu Province Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China; 2Department of Radiology, Jiangsu Province Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China POSTERS MONDAY JUNE 9TH

M199 THERAPY OF FIRST EPISODE OF STEROID RESPONSIVE NEPHROTIC SYNDROME: A RANDOMISED CONTROLLED TRIAL Carmine Pecoraro, Maria Rosaria Caropreso, Giovanni Passaro, Alfonso Vincenzo Salvatore Ferretti, Gabriele Malgieri. Department of Pediatrics, Children’s Hospital “Santobono”,Unit of Nephrology and Dialisys, Naples, Italy

M200 C2 LEVELS IN CYCLOSPORIN TREATED PATIENTS WITH NEPHROTIC SYNDROME Sotiria Alexandri, Dimitris Goumenos, Sotiris Tsakas, Irini Savidaki, Maria Kalantzi, John Vlachojannis. Internal Medicine - Nephrology, University Hospital, Patras, Greece

M201 CONCOMITANT ADMINISTRATION OF CYCLOSPORINE AND MONDAY KETOCONAZOLE IN STEROID NON-RESPONSIVE NEPHROTIC SYNDROME Amr Elhusseini, Ihab Mahmoud, Fathy El-Basuony, Nabil Hassan, Nagi Sayed, Mohamed Sobh. Nephrology, Mansoura Urology & Nephrology Center, Mansoura, El-Dakahlia, Egypt

M202 A SINGLE CENTER REPORT ON LONG-TERM EFFICACY AND SAFETY OF CYCLOSPORINE (CSA) TREATMENT IN 207 PATIENTS WITH IDIOPATHIC NEPHROTIC SYNDROME Fathy M. El-Bassouny, Nabeel A. Hasan, Nagy Abd El-Hady, Ihab M. Mahmoud, Amr A. El- Huseiny, Mohamed A. Sobh. Nephrology, Urology and Nephrology Center, Mansoura, Dakahlia, Egypt

M203 ONCE A DAY CICROSPORIN MICROEMULSION, NEORAL® THERAPY GUIDED BY ABSORPTION PROFILES IS USEFUL, SAFE AND COST-SAVING IN REFRACTORY NEPHROTIC SYNDROME Asami Takeda, Hiroshi Onoda, Yasuhiro Otsuka, Kazuharu Uchida, Kunio Morozumi. Kidney Center, Nagoya Daini Red Cross Hospital, Nagoya, Aichi, Japan

M204 THE EFFECTS OF CORTICOSTEROID THERAPY ON BONE METABOLISM IN NEPHROTIC SYNDROME Lin Song, Shan Lin, Mincai Qiu, Shuo Gao, Jun Li. Department of Nephrology, General Hospital of Tianjin Medical University, Tianjin, China

M205 IDIOPATHIC NEPHROTIC SYNDROME IN ADULTS-PREDICTORS OF HISTOLOGY AND THERAPEUTIC RESPONSE Sreelatha Melemadathil,1 Rajaratnam Krishnan,1 Aravindan Karumathil Puthanveedu,1 Ramdas Pisharody,1 K. Lakshminarayanan.2 1Department of Nephrology, Calicut Medical College, Kozhikode, Kerala, India; 2Department of Cytopathology & Immunology, Regional Cancer Centre, Trivandrum, Kerala, India

M206 MYCOPHENOLATE MOFETIL IN THE TREATMENT OF CHILDREN WITH STEROID DEPENDENT NEPHROTIC SYNDROME Maria Rosaria Caropreso, Alfonso Vincenzo Salvatore Ferretti, Gabriele Malgieri, Guido Raddi, Francesca Nuzzi, Carmine Pecoraro. Dept of Pediatrics, Santobono Hospital, Unit of Nephrology and Dialysis, Naples, Italy TH MONDAY JUNE 9 POSTERS

M207 EFFECTIVE AND SAFE TREATMENT OF PRIMARY NEPHROTIC SYNDROME WITH TACROLIMUS (FK 506) Joachim Beige,1 Ines Moosmayer,1 Lutz Liefeldt,2 Hans H. Neumayer,2 Walter Zidek,1 Harm Peters.2 1Dept. Endocrinology and Nephrology, Free University, Berlin, Germany; 2Dept. Nephrology, Charite, Campus Mitte, Humboldt- University, Berlin, Germany

M208 REDUCED PODOCYTE EXPRESSION OF a3b1 INTEGRINS AND PODOCYTE DEPLETION IN PATIENTS WITH PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS AND CHRONIC PUROMYCIN AMINONUCLEOSIDE -TREATED RATS Chien-An Chen,1 Jyh-Chang Hwang,1 Jinn-Yuh Guh,2 Chien-Jen Lin,1 Hung-Chun Chen,2 Yung-Hsiung Lai.2 1Division of Nephrology, Chi-Mei Foundation Hospital, Tainin, Taiwan; 2Division of Nephrology, Kaohsiung Medical University, Kaohsiung, Taiwan

M209 NPHS2 AND ACTN4 GENES ANALYSIS IN ADULT ONSET, NON- FAMILIAL, FOCAL SEGMENTAL GLOMERULOSCLEROSIS (FSGS) Filippo Aucella,1 Luigi Bisceglia,2 Giuseppe Gatta,1 Mimmo Vigilante,1 Giuseppe Di Giorgio,1 Michele D’Errico,1 Leopoldo Zelante,2 Carmine Stallone.1 1Nephrology and Dialysis, “Casa Sollievo della Sofferenza” IRCCS, San Giovanni Rotondo, Foggia, Italy; 2Medical Genetics, “Casa Sollievo della Sofferenza” IRCCS, San Giovanni Rotondo, Foggia, Italy

M210 PERMEABILITY ACTIVITY OF FSGS SERA: INCIDENCE, PARTIAL CHARACTERIZATION AND POTENTIAL MECHANISMS Virginia Savin, Ellen McCarthy, Deane Charba, Mukut Sharma. Nephrology, Medical College of Wisconsin, Milwaukee, WI, United States

M211 PERMEABILITY ACTIVITY IS PRESENT IN SERA FROM PATIENTS WITH COLLAPSING GLOMERULOPATHY Ellen McCarthy,1 Joshua Schwimmer,2 Mukut Sharma,1 Virginia Savin,1 Gerald Appel.2 1Divison of Nephrology, Medical College of Wisconsin, Milwaukee, WI, United States; 2Divison of Nephrology, Columbia University College of Physicians & Surgeons, New York, NY, United States

M212 PLASMA PERMEABILITY FACTOR (S) ISOLATED FROM PATIENTS WITH FOCAL SEGMENTAL GLOMERULOSCLEROSIS REDUCE (S) NEPHRIN AND PODOCIN EXPRESSION IN HUMAN GLOMERULAR EPITHELIAL CELLS Sophie Doublier,1 Tiziana Spatola,1 Giovanni Candiano,2 Luca Musante,2 Gianluca Caridi,2 Gian Marco Ghiggeri,2 Giovanni Camussi.1 1Department of Internal Medicine, University of Turin, Centro Ricerca Medicina Sperimentale (CeRMS), Turin, TO, Italy; 2Unit and Laboratory of Nephrology, Istituto G. Gaslini, Genoa, GE, Italy

M213 DOWN REGULATION OF PLASMA HEMOPEXIN ACTIVITY BY CORTICOSTEROIDS THROUGH MESANGIAL AND ENDOTHELIAL CELLS IN VITRO Jola Kapojos, Theo Borghuis, Anke van den Berg, Winston Bakker. Department of Pathology and Laboratory Medicine, University Hospital Groningen, Groningen, Netherlands POSTERS MONDAY JUNE 9TH

M214 HUMAN MESANGIAL CELLS EXPRESS HEMOPEXIN ON THEIR CELL MEMBRANES FOLLOWING ACTIVATION WITH TNFa IN VITRO Jola Kapojos,1 Rianne Jongman,1 Theo Borghuis,1 Bernhard Banas,2 Marieke Bruinsma,1 Winston Bakker.1 1Department of Pathology and Laboratory Medicine, University Hospital Groningen, Groningen, Netherlands; 2Nephrological Center, Medical Policlinic, Ludwig-Maximilians University, Munich, Germany

M215 GENETIC MARKERS FOR PROGRESSION OF FOCAL- SEGMENTAL GLOMERULOSCLEROSIS TO UREMIA Paolo Catarsi,1 Gian Marco Ghiggeri,1 Alba Carrea,1 Monica Dagnino,1 Gianluca Caridi,1 Francesco Emma,2 Francesco Scolari,3 Simone Sanna-Cherchi,4 Monica De Luca,2 Francesca Giacopelli,5 Gian Franco Rizzoni,2 Rosanna Gusmano,6 Roberto Ravazzolo,5 MONDAY Francesco Perfumo.1 1Dept. of Nephrology - Lab. of Physopathology of Uremia, G. Gaslini Institute, Genoa, Italy; 2Nephrology Unit, Bambino Gesù Hospital, Rome, Italy; 3Nephrology Unit, Spedali Civili, Brescia, Italy; 4Dept. of Clinical Medicine and Genetics, University, Parma, Italy; 5Lab. of Molecular Genetics, G. Gaslini Institute, Genoa, Italy; 6Foundation for Studies on Renal Diseases in Children, Genoa, Italy

M216 COAGULATION FACTOR GENES POLYMORPHISMS IN PRIMARY SPORADIC FOCAL SEGMENTAL GLOMERULOSCLEROSIS Simone Sanna Cherchi,1 Federica Riccardi,2 Maria Saura Alvarez,2 Davide Martorana,2 Landino Allegri,1 Tauro Maria Neri.2 1Department of Clinical Medicine, Nephrology and Health Sciences, Section of Nephrology, University of Parma, Parma, Italy; 2Laboratory of Molecular Genetics and Diagnostic Biotechnologies, University of Parma, Parma, Italy

M217 IDIOPATHIC FOCAL SEGMENTAL GLOMERULOSCLEROSIS: AN IMPORTANT CAUSE OF END-STAGE RENAL FAILURE IN THAILAND Vuddhidej Ophascharoensuk, Derek Bunnachuk, Dusit Lumlertgul. Renal Division, Department of Medicine, Chiang Mai University, Chiang Mai, Thailand

M218 CLINICAL AND PATHOLOGICAL FEATURES OF OBESITY- ASSOCIATED FOCAL SEGMENTAL GLOMERULOSCLEROSIS Bao Dong, YiPu Chen, Wen Chen, Hong Cheng, An Li, Yun Jiang, WanZhong Zou. Center of Nephrology, China-Japan Friendship Hospital, Beijing, China

M219 PREDICTING RENAL SURVIVAL IN IRANIAN CHILDREN WITH FOCAL SEGMENTAL GLOMERULOSCLEROSIS Alaleh Gheisari,1 Hasan Otookesh,2 Abbas Madani.3 1Pediatric Nephrology, St Zahra Hospital, Esfahan, Islamic Republic of Iran; 2Pediatric Nephrology, St Ali Asghar Hospital, Tehran, Islamic Republic of Iran; 3Pediatric Nephrology, Dr Ahari Childrens Hospital, Tehran, Islamic Republic of Iran

M220 EVALUATION OF STEROID RESPONSE IN PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS ( A SINGLE CENTER STUDY IN IRAN) Monirsadat Hakemi, Iraj Najafi, Mohammad Reza Ganji, Sepideh Rezaei. Nephrology Research Center, Shariat Hospital,Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran

M221 STEROID RESPONSE IN PRIMARY FSGS: DOES BASELINE FEATURES MATTER Ejaz Ahmed,1 Rubina Naqvi,1 Jawaid Kazi,2 Sajid Bhatti,1 Huma Noor,1 Fazal Akhtar,1 Anwar Naqvi,1 Adib Rizvi.1 1Nephrology, Siut- Civil Hospital, Karachi, Sindh, Pakistan; 2Pathology, Siut-Civil Hospital, Karachi, Sindh, Pakistan TH MONDAY JUNE 9 POSTERS

M222 ONE- YEAR SURVIVAL AND RENAL FUNCTION OUTCOME IN PATIENTS TREATED BY PLASMAPHERESIS FOR GOODPASTURE SYNDROME: A 73 CASE REPORT STUDY Anne Gaëlle Josse,1 Nassim Kamar,2 Eric Bauvin,3 Jean Michel Korach,4 Valérie Canses-Lauwers,3 Olivier Cointault,2 Lionel Rostaing,2 Jacques Pourrat.1 1Dept Nephrology & Clinical Immunology, CHU Purpan, Toulouse, France; 2Dept Nephrology, Dialysis & Transplantation, CHU Rangueil, Toulouse, France; 3Dept Epidemiology, Med Fac Purpan, Toulouse, France; 4Dept Reanimation, CH, Chalon en Champagne, France

M223 MACROPHAGE INFILTRATION IN CHRONIC GLOMERULONEPHRITIS: THE ROLE OF PROTEINURIA, MCP- 1/CCL2 AND CCR2 Kevin Eardley, Dwomboa Adu, Caroline Savage, Paul Cockwell. Department of Nephrology, University Hospital Birmingham, Birmingham, United Kingdom

M224 EXPRESSION OF THE CHEMOKINE RECEPTOR CXCR3 IN HUMAN GLOMERULONEPHRITIS Stephan Segerer,1 Bernhard Banas,1 Markus Wörnle,1 Matthias Mack,1 Peter J. Nelson,1 Detlef Schlöndorff,1 Hermann-Josef Gröne.2 1Medizinische Poliklinik, University of Munich, Munich, Germany; 2Department of Cellular and Molecular Pathology, Deutsches Krebsforschungszentrum, Heidelberg, Germany

M225 THE EXPRESSION OF PLATELET-DERIVED GROWTH FACTOR RECEPTOR ALPHA (PDGF-Ra) AND ITS LIGAND PDGF-AA IN HUMAN GLOMERULONEPHRITIS (GN) Ewa Miller-Kasprzak, Zofia I. Niemir, Pawel Olejniczak, Artur Nowak, Stanislaw Czekalski. Department of Nephrology, University of Medical Sciences, Poznan, Poland

M226 IMPAIRED ACTIN FILAMENT REMODELLING PREDISPOSING TO GLOMERULAR DAMAGE IN GLOMERULONEPHRITIS Saeed Ahmed,1 Trevor Thomas,1 Paul Mead.2 1School of Clinical Medical Sciences, Newcastle University, Newcastle, United Kingdom; 2Renal Medicine, Cumberland Infirmary, Carlisle, United Kingdom

M227 INTERACTION OF ANGIOTENSIN CONVERTING ENZYME (ACE) INSERTION/DELETION (I/D) POLYMORPHISM AND ANTIPROTEINURIC EFFECTS OF LOSARTAN IN PATIENTS WITH NONDIABETIC CHRONIC RENAL DISEASE Hyeong Cheon Park,1 Hoon Young Choi,1 Zhong-Gao Xu,2 So Rae Choi,1 Shin Wook Kang,1 Kyu Hyun Choi,1 Sung Kyu Ha,1,2 Ho Yung Lee,1 Dae Suk Han.1,2 1Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea; 2Brain Korea 21 Project for Medical Sciences Yonsei University, Seoul, Republic of Korea

M228 MAST CELLS ARE IMPORTANT CELLULAR COMPONENTS IN CHRONIC NEPHROPATY Ivone B. Oliveira, Sabrina G. Oliveira, Wagner V. Dominguez, Rui T. Barros, Viktoria Woronik, Paulo S. Quintaes, Irene L. Noronha. Renal Division, University of São Paulo, São Paulo, Brazil

M229 THE SIGNIFICANCE OF ENDOGENOUS OUABAIN VARIANCE IN GLOMERULAR DISEASES OR WHEN RENAL FUNCTION DECREASE Aiping Yin, Zhuoren Lv. Renal Medicine, The First Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China POSTERS MONDAY JUNE 9TH

M230 THE ROLE OF MATRIX METALLOPROTEINASE-9 IN HUMAN MESANGIAL PROLIFERATIVE GLOMERULONEPHRITIS Maki Urushihara,1 Shoji Kagami,1 Takashi Kuhara,1 Shuji Kondo,1 Akiko Kitamura,1 Toshiaki Tamaki,2 Yasuhiro Kuroda.1 1Department of Pediatrics, School of Medicine, University of Tokushima, Tokushima, Japan; 2Department of Parmacology, School of Medicine, University of Tokushima, Tokushima, Japan

M231 PERIPHERAL BLOOD AND URINARY MONONUCLEAR CELLS IN GLOMERULONEPHRITIS: ASSOCIATION WITH DISEASE ACTIVITY AND EFFECTS OF ANGOIOTENSIN CONVERTING ENZYME INHIBITION Temurhan Kara, Serkan Kahraman, Hamza Okur, Gultekin Genctoy, Mustafa Arici, Bulent Altun, Yunus Erdem, Unal Yasavul, Cetin Turgan, Sali Caglar. MONDAY Internal Medicine-Nephrology, Hacettepe University Faculty of Medicine, Ankara,

M232 RENAL BIOPSY PROTOCOL FOR MONASH MEDICAL CENTRE: A SPECIALIZED APPROACH Paul Crammer, Alex Laslowski, John Dowling. Anatomical Pathology, Monash Medical Centre, Melbourne, Victoria, Australia

M233 INCIDENCE OF GLOMERULOPATHIES IN THE CZECH REGISTRY OF RENAL BIOPSIES (CRRB) IN THE YEAR 1995-2001 Eva Jancová,1 Vladimír Tesar,1 Josef Stejskal,2 Alena Stejskalová.3 1First Dept. Medicine, First Faculty Medicine, Prague, Czech Republic; 2Dept. of Pathology, Third Faculty Medicine, Prague, Czech Republic; 3Dept. of Pathology, First Faculty Medicine, Prague, Czech Republic

M234 EPIDEMIOLOGIC STUDY OF GLOMERULAR DISEASE -CASE SERIES REPORT Shahrzad Ossareh,1 Afsoon E. Naeeini,1 Mojgan Asgari,2 Ghodratollah Ghorbani,2 Ahad J. Ghods.1 1Nephrology, Iran University of Medical Sciences, Tehran, Islamic Republic of Iran; 2Pathology, Iran University of Medical Sciences, Tehran, Islamic Republic of Iran

M235 GLOMERULAR DISEASE IN CHILDREN “A REPORT FROM SOUTH ISLAMIC REPUBLIC OF IRAN” Ghamar Hashemi,1 A. Derakhshan,1 M.H. Fallahzadeh. 1Pediatric Nephrology, UniversShiraz ity of Nedical Sciences, Shiraz, Fars, Islamic Republic of Iran; 2Pediatric Nephrology, UniversShiraz ity of Nedical Sciences, Shiraz, Fars, Islamic Republic of Iran

M236 PATHOLOGICAL AND EPIDEMIOLOGICAL CHARACTERISTICS OF ADULT PATIENTS WITH RENAL DISEASE IN CENTRAL ISRAEL-A 10 YEAR RETROSPECTIVE REVIEW Alex Blau,1 Margarita Kunin,1 Hannah Fenigstein,1 Aharon Ben David,1 Juri Kopolovic.2 1Nephrology and Hypertension, 2Department of Pathology, Chaim Sheba Medical Center, Tel Hashomer, Israel

M237 GLOMERULONEPHRITIS IN OCCUPATIONAL EXPOSURE PATIENTS, A LIGHT MICROSCOPIC STUDY OF 375 AUTOPSY CASES Anucha Puapairoj,1 Koichi Honma.2 1Pathology, Faculty of Medicine,Khon Kaen University, Muang, Khon Kaen, Thailand; 2Pathology, Dokkyo University, Mibu, Tochigi, Japan

M238 FAMILIAL CLUSTERING OF DIFFERENT FORMS OF PRIMARY GLOMERULONEPHRITIS: VALTROMPIA STUDY Francesco Scolari,1 Elisabetta Prati,2 Battista Fabio Viola,1 Simona Guerini,1 Rosario Maiorca.1 1Chair of Nephrology, university of Brescia, Brescia, Italy; 2Dialysis Service, Desenzano Hospital, Desenzano, Brescia, Italy TH MONDAY JUNE 9 POSTERS

M239 ACQUIRED FACTOR X DEFICIENCY IN A PATIENT WITH ESRD AND FIBRILLARY GLOMERULONEPHRITIS E. Platen,1 M. Reber,1 H.-J. Hertfelder,2 R. Woitas,1 H.-U. Klehr.1 1Medizinische Klinik I, Universitätsklinik, Bonn, Germany; 2Institut für Haemostaseologie, Universitätsklinik, Bonn, Germany

M240 GLOMERULONEPHRITIS IN PATIENTS WITH HYDATID DISEASE (HD) Fatma Ben Moussa, Rym Goucha, Hayet Kaaroud, Hafedh Hedri, Soumaya Beji, Hedi Ben Maiz. Nephrology and Internal Medicine, Charles Nicolle Hospital, Tunis, Tunisia

M241 ASSESSMENT OF NITRIC OXIDE(NO) AND LEVELS IN DIFFERENT CLINICAL AND PATHOLOGICAL TYPES OF GLOMERULAR DISEASES Salwa Ibrahim,1 Hanan Fouad,2 Gamal Mohsen,2 Laila Rashed,2 Nashwa El-Tablawy.3 1Department of Internal Medicine, 2Department of Medical Biochemistry, 3Department of Physiology, Cairo University, Cairo, Egypt

M242 ENDOTHELIAL FUNCTION, INFLAMMATION, AND PROTEINURIA IN PATIENTS WITH PRIMARY GLOMERULONEPHRITIS Bruce Mackinnon,1 Christoher Deighan,1 Naveed Sattar,2 Jonathan Fox.1 1Renal Unit, Glasgow Royal Infirmary, Glasgow, Scotland, United Kingdom; 2Department of Pathological Biochemistry, Glasgow Royal Infirmary, Glasgow, Scotland, United Kingdom

M243 ASSOCIATION OF RENAL HAEMODINAMICS DETERMINED BY DOPLLER ULTRASOUND WITH MORPHOLOGICAL ACTIVITY AND CHRONICITY INDICES IN PATIENTS WITH CHRONIC GLOMERULONEPHRITIS Serguey Martynov,1 Mikhail Shvetsov,1 Vera Kushnir,1 Bolot Dzhanaliev,2 Vladimir Varshavsky,2 Ekaterina Golitsina,2 Irina Kutyrina.1 1Department of Nephrology, Moscow Sechenov Medical Academy, Moscow, Russian Federation; 2Department of Pathomorphology

M244 URINARY MONOCYTE CHEMOTACTIC PROTEIN-1 (MCP-1), REGULATED UPON ACTIVATION NORMAL T-CELL EXPRESSED AND SECRETED CHEMOKINE (RANTES) AND TRANSFORMING GROWTH FACTOR-BETA1 (TGF-BETA1) IN CHILDREN WITH CHRONIC GLOMERULONEPHRITIS Katarzyna Kilis-Pstrusinska, Anna Medynska, Danuta Zwolinska. Dept. of Paediatric Nephrology, Wroclaw Medical University, Wroclaw, Poland

M245 THE EFFECT OF Th2-DEPENDENT CYTOKINE GENE EXPRESSION ON PROGRESSION OF PRIMARY GLOMERULAR DISEASE Zbigniew Hruby,1 Dariusz Sowinski,1 Bronislaw Tyran,2 Zbigniew Zdrojewski,3 Tomasz Irzyniec,4 Michal Sroka,1 Andrzej Wiecek.4 1Department of Nephrology, Voivodship Specialty Hospital, Wroclaw, Poland; 2Wroclaw Medical University, Wroclaw, Poland; 3Gdansk Medical University, Gdansk, Poland; 4Silesian Medical University, Katowice, Poland

M246 PROTECTIVE SIGNIFICANCE OF INTERLEUKIN-10 IN PATHOGENESIS OF TUBULOINTERSTITIAL CHANGES IN CHILDREN WITH CHRONIC GLOMERULONEPHRITIS Kartamysheva Nataliya, Chumakova Olga, Kucherenko . Department of Osteoporosis and Metabolic Duseases, Scientiphic Centre of Children’s Health, Moscow, Russian Federation POSTERS MONDAY JUNE 9TH

M247 RENAL ERYTHROPOIETIN RECEPTOR EXPRESSION CORRELATES WITH THE SEVERITY OF HUMAN GLOMERULONEPHRITIS Masayo Echigoya, Satoshi Sasaki, Katsuyuki Obikane, Kunihiko Kobayashi. Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan

M248 INFLUENCE OF GENETIC POLYMORPHISMS OF RENIN ANGIOTENSIN SYSTEM ON CHRONIC GLOMERULONEPHRITIS Christos Bantis, Katrin Ivens, Nicola Klein-Vehne, Bernd Grabensee, Peter J. Heering. Department of Nephrology and Rheumatology, Heinrich-Heine University, Duesseldorf, Germany MONDAY M249 AMOUNT OF URINARY TRANSFERRIN IS A PREDICTOR OF RENAL DYSFUNCTION IN PATIENTS WITH PRIMARY GLOMERULONEPHRITIS Emiko Houki, Akinori Soejima, Kimimasa Nakabayashi, Akira Yamada, Toshihiko Nagasawa. First Dept. Int. Med., Kyorin Univ. Sch. Med., Mitaka, Tokyo, Japan

M250 THE VVANNTT STUDY: VERAPAMIL VERSUS AMLODIPINE IN NONDIABETIC NEPHROPATHIES TREATED WITH TRANDOLAPRIL Roberto Boero,1 Cristiana Rollino,1 Carlo Massara,1 Mauro Berto,2 Paolo Perosa,3 Giuseppe Vagelli,4 Giacomo Lanfranco,5 Francesco Quarello.1 1Nephrology, S.G. Bosco Hospital, Torino, Italy; 2Nephrology, Degli Infermi Hospital, Biella, Italy; 3Nephrology, Agnelli Hospital, Pinerolo, Italy; 4Nephrology, S Spirito Hospital, Casale, Italy; 5Nephrology, Molinette Hospital, Torino, Italy

M251 RENAL HAEMODYNAMIC RESPONSE TO ACE INHIBITOR IN CHRONIC GLOMERULONEPHRITIS DETERMINED BY COLOR DOPPLER SONOGRAPHY IN ACUTE CAPTOPRIL TEST Mikhail Shvetsov, Serguey Martynov, Vera Kushnir, Irina Kutyrina. Department of Nephrology, Moscow Sechenov Medical Academy, Moscow, Russian Federation

M252 HIGH DOSAGES OF ARA 1 AND ACE INHIBITORS IN RENAL PROTECTION Dmytro Ivanov,1 Stella Kushnirenko,2 Nestani Mehatisvili,3 Olena Medvedskay,4 Olena Taran.5 1Nephrology, 2Pediatric Nephrology, Medical Academy of Postgraduate Education, Kyiv, ; 3Pediatric Nephrology, Pediatric Hospital, Dnepropetrovsk, Ukraine

M253 CYCLOOXYGENASE (COX)-2 SELECTIVE INHIBITORS + ACE INHIBITORS: A NEW PROTOCOL IN THE TREATMENT OF HEAVY PROTEINURIA Stefano Costanzi,1 Antonio Sturniolo,1 Pierluigi Fulignati,1 Stefano Passalacqua,1 Emiliano Staffolani,2 Silvia D’Alonzo,1 Giorgio Splendiani.2 1Department of Nephrology, C.I.Columbus - University of Sacred Heart, Rome, Italy; 2Chair of Nephrology, University Tor Vergata, Rome, Italy

M254 CYCLOSPORINE A (NEORAL) C2 MONITORING IN THE TREATMENT OF SEVERE NEPHROPATHIES: A PILOT STUDY Boriana Deliyska,1 Margarita Bankova,1 Anoushka Rapondjieva,1 Dobrin Svinarov.2 1Clinic of Nephrology, Medical University, Sofia, Bulgaria; 2Clinical Laboratory, Medical University, Sofia, Bulgaria TH MONDAY JUNE 9 POSTERS

M255 MYCOPHENOLATE MOFETIL TREATMENT IN PATIENTS WITH GLOMERULONEPHRITIS THAT IS REFRACTORY TO CONVENTIONAL IMMUNOSUPPRESSIVE THERAPY Aydin Turkmen,1 Savas Ozturk,1 Mine Besler,2 Sevgi Sahin,3 Gulizar Manga,4 Mehmet Kucuk,1 Ergin Ark.1 1Nephrology, Istanbul School of Medicine, Istanbul, Turkey; 2Nephrology, SSK Istanbul Hospital, Istanbul, Turkey; 3Nephrology, SSK Goztepe Hospital, Istanbul, Turkey; 4Nephrology, Haydarpasa Numune Hospital, Istanbul, Turkey

M256 COMBINATION OF TACROLIMUS AND LOW DOSE METHYLPREDNISOLONE IN THE TREATMENT OF RESISTANT PRIMARY GLOMERULONEPHRITIS (PGN) Hakki Arikan,1 Serhan Tuglular,1 Gulcin Kantarci,2 Betul Ogutman,1 Emel Akoglu.1 1Nephrology, Marmara University School of Medicine, Istanbul, Turkey; 2Nephrology, Marmara University School of Medicine, Istanbul, Turkey; 3Nephrology, Goztepe Reserching Hospital, Istanbul, Turkey; 4Nephrology, Marmara University School of Medicine, Ist POSTERS MONDAY JUNE 9TH

HYPERTENSION: CLINICAL

M257 ACTIVITY OF SELECTED SYSTEMS OF SODIUM TRANSPORT TROUGH ERYTHROCYTE CELLULAR MEMBRANE IN PATIENTS WITH ESSENTIAL AND SECONDARY HYPERTENSION Joanna Bober,2 Karolina Kedzierska,1 Ewa Kwiatkowska,1 Magdalena Wisniewska,1 Kazimierz Ciechanowski,1 Marek Myslak,1 Jerzy Wiatrow.3 1Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland; 2Biochemistry and Chemistry, Pomeranian Medical University, Szczecin, Poland; 3Dialysis Department, Regional Hospital, Choszczno, Poland MONDAY M258 LACK OF MUTATIONS IN C-TERMINI OF SUBUNITS OF THE EPITHELIAL SODIUM CHANNEL IN 15-YEARS OLD GIRL WITH PHENOTYPE OF LIDDLE’S SYNDROME Jolanta Antoniewicz,1 Mieczyslaw Litwin,1 Grzegorz Placha,2 Grazyna Adler,3 Andrzej Ciechanowicz.3 1Nephrology and Kidney Transplantation, The Childrens Memorial Health Institute, Warszawa, Poland; 2Internal Medicine and Hypertension, Medical University, Warszawa, Poland; 3Pathobiochemistry and Molecular Biology, Pomeranian Medical University, Szczecin

M259 SALT TASTE SENSITIVITY AND BLOOD PRESSURE IN NORMOTENSIVE INDIVIDUALS Mendel Rabin, Ivan Carlos Ferreira Antonello, Eduardo Martins Carvalho, Daniel Vilhordo, Carlos Abaete de los Santos, Domingos d’Avila. Programa de Pós-Graduação em Clínica Médica (Nefrologia) Faculdade de Medicina, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil

M260 HIGH SODIUM INTAKE CAN INDUCE AN UNFAVORABLE RENAL HEMODYNAMIC RESPONSE IN NORMOTENSIVE SUBJECTS Menno J.A. Kocks, Paul E. de Jong, Gerjan Navis. Nephrology, University Medical Center Groningen, Groningen, Netherlands

M261 RELATIONSHIP BETWEEN BLOOD PRESSURE (BP) DIURNAL RHITHM AND DAY-NIGHT PROTEIN, SODIUM AND POTASSIUM EXCRETION CHANGES IN PATIENTS (pts) WITH CRONIC KIDNEY DISEASE (CKD) Nina Naidenova, Ashot Essaian, Alexey Smirnov. Department of Nephrology and Dialysis, St.Petersburg Pavlov’s Medical University, St.Petersburg, Russian Federation

M262 FAMILIAL PARTIAL GLUCOCORTICOID RESISTANCE SYNDROME: AN UNDERDIAGNOSED CAUSE OF HYPOKALAEMIA AND HYPERTENSION Mohmed Ahmed Eltoum, G. Venkat Raman. Renal Unit, Queen Alexandra Hospital, Portsmouth, Hants, United Kingdom

M263 ALDOSTERONE AND OXIDATIVE STRESS RELATED GENE AND PROTEIN EXPRESSION. FIRST REPORT IN A CONN’S ADENOMA TISSUE Lorenzo Calo,1 Francesca Zaghetto,1 Paul Davis,2 Elisa Pagnin,1 Michelangelo Sartori,1 Gianpaolo Rossi,1 Andrea Semplicini.1 1Clin Exp Med, Clinica Medica 4, University of Padova, Padova, Italy; 2Int Med, Clin Nutrition, University of California, Davis, CA, United States TH MONDAY JUNE 9 POSTERS

M264 RAPID VASCULAR ALDOSTERONE EFFECTS TO THE RENAL VASCULATURE DURING BLOCKADE OF THE NO-SYSTEM Bernhard M.W. Schmidt, Ulla Sammer, Sebastian Oehmer, Christian Delles, Erwin H. Fleischmann, Roland E. Schmieder. Medical Department IV, University of Erlangen-Nuremberg, Nuremberg, Germany

M265 RENAL HYPERFILTRATION AND INCREASED PREVALENCE OF CYSTIC DISEASE IN PATIENTS WITH PRIMARY ALDOSTERONISM Cristiana Catena, Marileda Novello, Luciana Dotto, Maria Cecilia Somma, Sara Baroselli, Alessandro Cavarape, Sergio De Marchi, Leonardo Sechi. Internal Medicine, Hypertension Unit, University of Udine, Udine, UD, Italy

M266 RAPID ALDOSTERONE EFFECTS IN THE HUMAN FOREARM VASCULATURE Bernhard M.W. Schmidt, Sebastian Oehmer, Christian Delles, Markus P. Schneider, Arnfried Klingbeil, Erwin H. Fleischmann, Roland E. Schmieder. Medical Department IV, University of Erlangen-Nuremberg, Nuremberg, Germany

M267 ALDOSTERONE IS A PREDICTIVE FACTOR FOR LEFT VENTRICULAR HYPERTROPHY IN PATIENTS WITH RENAL DISEASES TREATED BY ANTIHYPERTENSIVE DRUGS Tomoko Gomi, Yuko Shibuya, Takasi Kosugi, Kiyoko Matuo, Takao Kawada, Toshio Ikeda. Department of Nephrology, Kanto Medical Center, Tokyo, Japan

M268 SERUM URIC ACID IS APART TO THE METABOLIC SYNDROME RELATED TO THE SERUM ALDOSTERON CONCENTRATION IN ESSENTIAL HYPERTENSION Mario Kašner,1 Bojan Jelakovic,1 Mario Laganovic,1 Duško Kuzmanic,1 Gordana Boršo,1 Tajana Zeljkovic,1 Tomislav Roncevic,1 Tomislav Šmuc,2 Dragan Gamberger,2 Pavle Roncevic.1 1InternalMedicine, University Hospital Center Zagreb, Zagreb, Croatia; 2Institute “Ruðer Boškovic”Zagreb, Croatia

M269 LOW BIRTH WEIGHT DOES NOT INFLUENCE BLOOD PRESSURE THROUGH REDUCED KIDNEY VOLUME Mario Laganovic,1 Bojan Jelakovic,1 Duško Kuzmanic,1 Gordana Boršo,1 Tomislav Roncevic,1 Mirko Vdovic,1 Tajana Zeljkovic,1 Mario Kašner,1 Tomislav Šmuc,2 Dragan Gamberger.2 1Internal Medicine, University Hospital Center Zagreb, Zagreb, Croatia; 2Institute RuÐer Boškovic, Zagreb, Croatia

M270 COMPLEX REARRANGEMENTS IN THE SEGMENT FOR HYPERTENSION AND BRACHYDACTYLY ON THE SHORT ARM OF CHROMOSOME 12 Sylvia Bähring,1,2 Anita Rauch,3 Atakan Aydin,1,2 Hakan R. Toka,4 Okan Toka,5 Veronique Lefebvre,6 Jens ,1,2 Andre Reis,3 Friedrich C. Luft.1,2 1Genetics of Cardiovascular Diseases, Max Delbrück Center for Molecular Medicine, Berlin, Germany; 2Franz Volhard Clinic, HELIOS Klinikum-Berlin, Charite’Humboldt University of Berlin, Berlin, Germany; 3Institute of Human Genetics, Friedrich Alexander- University Erlangen-Nürnberg, Erlangen, Germany; 4Department of Genetics, Howard Hughes Medical Institute; Yale University School of Medicine, New Haven, CT, United States; 5Klinik fur Kinder und Jugendliche, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany; 6Department of Biomedical Engineering, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH, United States POSTERS MONDAY JUNE 9TH

M271 MARKERS OF OXIDATIVE INJURY AND LIPID PROFILE IN PATIENTS WITH ARTERIAL HYPERTENSION AND NEPHROSCLEROSIS Sonja Radenkovic,1 Nevenka Lecic,2 Tanja Cvetkovic,1 Nikola Radenkovic.3 1Dept. of Renal Disease Diagnostics, Institute of Nephrology and Hemodialysis, Nis, SR, Yugoslavia; 2Biochemistry Laboratory, Military Hospital, Nis, SR, Yugoslavia; 3Dept. of Computer Science, Faculty of Electronic Engineering, Nis, SR, Yugoslavia

M272 RENAL AND HORMONAL EFFECTS OF NO-INHIBITION IN PATIENTS WITH CONGESTIVE HEART FAILURE Jesper N. Bech,1 Hans Bentzen,1 Ole Nyvad,1 Anne Thomassen,2 Erling B. Pedersen.1,3 1Dept. of Medicine, Holstebro Hospital, Holstebro, Denmark; 2Dept. MONDAY of Medicine, Randers Hospital, Randers, Denmark; 3Aarhus University, Aarhus, Denmark

M273 COMBINED THERAPY BY THE DONATORS AND STIMULATORS OF NITRIC OXIDE SYNTHESIS OF A PATIENTS WITH NEPHROGENIC HYPERTENSION Ivan Topchy, Nataly Shabaltas, Alexander Zakharov, Tatjana Scherban. Nephrology, Institute of Therapy of Academy Medical Sciences, Kharkov, Ukraine

M274 VITAMIN C AUGMENTS THE RENAL RESPONSE TO L- ARGININE IN SMOKERS Markus P. Schneider, Christian Delles, Sebastian Oehmer, Thomas Schwarz, Roland E. Schmieder. Medicine IV/ Nephrology, University of Erlangen-Nürnberg, Nürnberg, Germany

M275 SYMPATHETIC ACTIVITY AND ASYMMETRIC DIMETHYL ARGININE (ADMA) IN PATIENTS WITH END STAGE RENAL DISEASE (ESRD) Francesca Mallamaci,1 Francesco A. Benedetto,1 Giovanni Tripepi,1 Renke Maas,2 Lorenzo Malatino,3 Graziella Bonanno,3 Francesco Rapisarda,3 Pasquale Fatuzzo,3 Giuseppe Seminara,3 Saverio Parlongo,1 Sebastiano Cutrupi,1 Benedetta Stancanelli,3 Rainer Boger,2 Carmine Zoccali.1 1Institute of Biomedicine CNR, Clinical Epidemiology and Pathophysiology of Renal Diseases and Hypertension, Reggio Calabria, Italy; 2Institute of Clinical Pharmacology, Hamburg University, Hamburg, Germany; 3Department of Internal Medicine, Catania University, Catania, Italy

M276 MODULATION OF RENAL FUNCTION IN HUMANS BY SYSTEMIC INFUSION OF SUBPRESSOR DOSES OF THE ENDOGENOUS NO-SYNTHASE INHIBITOR ASYMMETRIC DIMETHYLARGININE (ADMA) Jan T. Kielstein,1 Solveig Simmel,1 Burcu Impraim,1 Stefanie M. Bode- Böger,2 Hermann Haller,1 Danilo Fliser.1 1Nephrology, Medical School Hannover, Hannover, Germany; 2Institute for Clinical Pharmacology, “Otto-von-Guericke” University, Magedeburg, Germany

M277 ROLE OF BLOOD PRESSURE ON CHRONIC INFLAMMATION AND ENDOTHELIAL FUNCTION IN UNTREATED ESSENTIAL HYPERTENSIVE PATIENTS Vincenzo Panichi,1 Lorenzo Ghiadoni,1 Daniele Taccola,1 Massimiliano Migliori,2 Cristina Filippi,2 Cristina Consani,1 Luca Giovannini,2 Stefano Taddei,1 Antonio Salvetti.1 1Internal Medicin, University of Pisa, Pisa, Italy; 2Neurosciencie, University of Pisa, Pisa, Italy TH MONDAY JUNE 9 POSTERS

M278 LOW PREVALENCE OF NONCONSERVATIVE MUTATIONS OF SERUM AND GLUCOCORTICOID-REGULATED KINASE (SGK1) GENE IN HYPERTENSIVE AND RENAL PATIENTS Nadia Trochen, Paolo Ferrari, Brigitte Frey, Felix Frey. Division of Nephrology and Hypertension, University Hospital, Berne, Switzerland

M279 POLYMORPHIC GENES FOR BRADYKININ RECEPTORS - ASSOCIATION WITH LEFT VENTRICULAR HYPERTROPHY IN ESSENTIAL HYPERTENSION Marcin Zychma, Janusz Gumprecht, Marcin Rekawek, Wladyslaw Grzeszczak. Internal Medicine, Diabetology and Nephrology, Silesian School of Medicine, Zabrze, Silesia, Poland

M280 GENETIC VARIANTS OF THE RENIN-ANGIOTENSIN SYSTEM AND EFFECTS OF ANGIOTENSIN II RECEPTOR BLOCKER Tadashi Konoshita, Yoshihiro Okuda, Manami Kurokawa, Shigeyuki Wakahara, Naomi Taniguchi, Isamu Miyamori. Third Department of Internal Medicine, Fukui Medical University, Matsuoka, Fukui, Japan

M281 THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM IN HYPERTENSIVE PATIENTS WITH NEPHROSCLEROSIS AND INCIPIENT RENAL FAILURE Cristiana Catena, Marileda Novello, Luciana Dotto, Alessandro Cavarape, Sergio De Marchi, Leonardo Sechi. Internal Medicine, Hypertension Unit, University of Udine, Udine, Italy

M282 INSULIN RESISTANCE IS AN INDIPENDENT PREDICTOR OF LEFT VENTRICULAR MASS IN TREATED HYPERTENSIVE PATIENTS Toshio Ikeda,1 Kiyoko Matsuo,1 Takeshi Kosugi,1 Yuko Shibuya,1 Tomoko Gomi,1 Chikayuki Yamada,2 Takashi Kasatani.2 1Department of Nephrology, NTT Kanto Medical Center, Tokyo, Japan; 2Department of Internal Medicine, Keiyu Clinic Takanawa, Tokyo, Japan

M283 n-3 POLYUNSATURATED FATTY ACIDS (PUFA) DECREASE LIPOPROTEIN(a) LEVELS IN HYPERTENSIVE PATIENTS Gianluca Colussi, Cristiana Catena, Sara Baroselli, Rosanna Varutti, Luciana Dotto, Marileda Novello, Alessandro Cavarape, Leonardo Sechi. Internal Medicine, Hypertension Unit, University of Udine, Udine, UD, Italy

M284 EFFECTS OF THE SINGLE DOSE ENALAPRIL AND SPIRONOLACTONE ON EXAGGERATED PLASMA PLASMINOGEN ACTIVATOR INHIBITOR TYPE-1 (PAI-1) AND TRANSFORMING GROWTH FACTOR BETA (TGF-b) RESPONSE TO PHLEBOTOMY IN HEALTHY BLOOD DONORS Celalettin Usalan,1 Seyma Tataroglu,2 Ozlem Tiryaki,2 Bulent Akgul,2 Ayten Oguz.2 1Nephrology, Gaziantep University, Gaziantep, Turkey; 2Internal Medicine, Gaziantep University, Gaziantep, Turkey

M285 WHITE COAT HYPERTENSION VS. PRIMARY HYPERTENSION: THE PREDICTIVE ROLE OF AMBULATORY BLOOD PRESSURE MONITORING ON THE INDICES OF ENDOTHELIAL FUNCTION Musa Aydinli, Serkan Kahraman, Erhan Akpinar, Gultekin Genctoy, Bulent Altun, Mustafa Arici, Aytekin Oto, Yunus Erdem, Serafettin Kirazli, Unal Yasavul, Cetin Turgan, Sali Caglar. Internal Medicine-Nephrology, Hacettepe University Faculty of Medicine, Ankara, Turkey POSTERS MONDAY JUNE 9TH

M286 IMMEDIATE TEMPORARY HYPERACTIVITY OF SIMPATHETIC NERVOUS SYSTEM AND PERMANENT DIASTOLIC HEART DISFUNCTION IN WHITE COAT HYPERTENSION ( WCH ) Mustafa Balal, Yahya Sagliker, Saime Paydas. Department of Nephrology-Hypertension, Cukurova University Medical Faculty, Adana, Turkey

M287 SAGLIKER EFFECT AND HYPERTENSIONOLOGIST HYPERTENSION. A KIND OF HARAKIRI EFFECT? SHOULD MANUAL BP RECORDINGS BE BANNED? Yahya Sagliker,1 Mustafa Balal,1 Nuray Paylar,2 Cemal Sagliker,3 Piril Sagliker,2 Hasan Sabit Sagliker,4 Saime Paydas.1 1Cukurova University, Medical Faculty, Adana, Turkey; 2Sagliker Hypertension Center, Adana, Turkey; 3Health Ministry, State Health Center, Adana, Turkey; 4Erciyes University, Medical Faculty, MONDAY Kayseri, Turkey

M288 IMPROVEMENT IN HYPERTENSION MANAGEMENT IN TYPE 1 AND INSULIN TREATED TYPE 2 DIABETES MELLITUS 1989/90 – 1999/2000 (JEVIN) Ralf Schiel,1 Ulrich A. Müller,2 Günter Stein.1 1University of Jena Medical School, Department of Internal Medicine IV, Jena, Germany; 2University of Jena Medical Schoool, Department of Internal Medicine II, Jena, Germany

M289 PULSE PRESSURE IN PATIENTS WITH RENAL HYPERTENSION Istvan Barna, Csaba Henrik Horvath. First Department of Medicine, Semmelweis University, Budapest, Hungary

M290 PULSE PRESSURE PREDICTS MORTALITY IN PATIENTS ON HEMODIALYSIS THE DIFFERENCE BETWEEN DIABETICS AND NON DIABETICS Debasish Banerjee,1 Brian Walters,2 Jose Nebut,2 Juan Bosch,2 Phillip Pennell.1 1Medicine/Nephrology, University of Miami, Miami, FL, United States; 2Outcomes Research, Gambro Healthcare, Ft Lauderdale, FL, United States

M291 DETERMINANT FACTORS OF PULSE PRESSURE IN CHRONIC RENAL DISEASE Soledad García de Vinuesa, María Angeles Goicoechea, Francisco Gómez Campderá, Loreto Fernández, José Luño. Department of Nephrology, Hospital General Universitario Gregorio Marañón, Madrid, Spain

M292 CHANGES OF POSTPRANDIAL PULSE PRESSURE ARE RELATED TO RENAL FUNCTION IN PATIENTS WITH ESSENTIAL HYPERTENSION AND DIABETES MELLITUS Z. Zhu,2 Z. Yan,2 J. Yu,2 D. Liu,2 Z. Zhao,2 M. Tepel.1 1Med. Klinik IV, Univ. Klinik Benjamin Franklin, Berlin, Germany; 2Department of Hypertension and Endocrinology, Chongqing Hypertension Institute, Chongqing, China

M293 BLOOD PRESSURE VARIATION AND EXERCISE-INDUCED HYPERTENSION IN NORMOTENSIVE INDIVIDUALS Mendel Rabin, Ivan Antonello, Daniel Vilhordo, Carlos Abaeté de los Santos, Carlos E. Poli de Figueiredo, Domingos d’Avila. Programa de Pós-Graduação em Clínica Médica (Nefrologia). Faculdade de Medicina, PUCRS, Porto Alegre, RS, Brazil

M294 HEART RATE VARIABILITY IN PATIENTS WITH NEPHROGENIC HYPERTENSION AT VARIOUS TYPES OF DAILY BLOOD PRESSURE PROFILE I.V. Shishkina, N.L. Tov, E.A. Movchan, O.G. Chudinova. Novosibirsk State Medical Academy, Novosibirsk State Regional Clinical Hospital, Novosibirsk, Russian Federation TH MONDAY JUNE 9 POSTERS

M295 PROGNOSTIC SIGNIFICANCE OF 24 HOUR AMBULATORY BLOOD PRESSURE MONITORING IN PATIENTS OF CHRONIC RENAL FAILURE,END STAGE RENAL DISEASE AND RENAL TRANSPLANTATION Sunil Prakash,1 Sumedha Chibber,1 Dwareka Pande,1 Krishan Gupta,1 Susham Sharma,1 Hrishikesh Kulkarni.2 1Division of Nephrology, Dept. of Medicine, Northern Railway Central Hospital, New Delhi, Delhi, India; 2Department of Medicine, Surya Hospital, Pune, Maharasthra, India

M296 FACTORS DETERMINING THE PROGRESSION OF RENAL FAILURE IN ESSENTIAL HYPERTENSION Atsuo Goto,1 Kaoru Yamada,2 Hideyuki Negoro,1 Akihiro Tojyo,1 Etsu Suzuki,1 Toshiro Fujita.1 1Internal Medicine, University of Tokyo, Tokyo, Japan; 2Health Care, Sanraku Hospital, Tokyo, Japan

M297 ANALYSIS OF OUTCOME AND PROGNOSTIC FACTORS IN PATIENTS WITH RENAL MALIGNANT HYPERTENSION Xuyang Cheng, Minghui Zhao, Xiaomei Li, Haiyan Wang. Renal Division, Department of Medicine, First Hospital and Institute of Nephrology, Peking University, Beijing, China POSTERS MONDAY JUNE 9TH

DIABETES MELLITUS: CLINICAL

M298 TUBULO-INTERSTITIAL CHEMOKINE AND CHEMOKINE RECEPTOR mRNA EXPRESSION IN PROGRESSIVE DIABETIC NEPHROPATHY (DN): IS PROGRESSIVE DN AN INFLAMMATORY DISEASE? Holger Schmid, Anna Henger, Clemens D. Cohen, Peter J. Nelson, Detlef Schloendorff, Matthias Kretzler. Nephrological Center, Medical Policlinic, Ludwig-Maximilians- University, Munich, Germany

M299 THE INVOLVEMENT OF MITOGEN-ACTIVATED PROTEIN

KINASE (MAPK) IN THE PROGRESSION OF HUMAN DIABETIC MONDAY NEPHROPATHY Norihiko Sakai, Takashi Wada, Kengo Furuichi, Junya Yamahana, Satoshi Kokubo, Kiyoki Kitagawa, Motoo Kobayashi, Hitoshi Yokoyama. Department of Gastroenterology and Nephrology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan

M300 EVALUATION OF TRANSFORMING GROWTH FACTOR -BETA 1(TGF-b1) IN TYPE II DIABETIC PATIENTS WITH DIABETIC NEPHROPATHY Salwa Ibrahim,1 Lilla Rashed.2 1Department of Medicine, Cairo University, Cairo, Egypt; 2Department of Medical Biochemistry, Cairo University, Cairo, Egypt

M301 TUBULAR STAINING OF MODIFIED C-REACTIVE PROTEIN INCREASES WITH SEVERITY OF DIABETIC NEPHROPATHY Susanne B. Schwedler,1 Frank Guderian,1 Jobst Daemmrich,2 Lawrence A. Potempa,3 Christoph Wanner.1 1Department of Medicine, Division of Nephrology, University of Wuerzburg, Wuerzburg, Germany; 2Institute of Pathology, Schweinfurt, Germany; 3NextEra Therapeutics, Vernon Hills, IL, United States

M302 ERYTHROCYTE SODIUM-LITHIUM COUNTERTRANSPORT (SLC) ACTIVITY IN BANGLSDESHI TYPE 2 DIABETIC SUBJECTS WITH OR WITHOUT NEPHROPATHY Masud Iqbal,1 N.S. Chowdhury,2 H.S. Chaudhury,2 S. Alam,3 H. Rahman,4 H.U. Rashid,4 Z. Kabir,1 L. Ali.2 1Nephrology, National Institute of Kidney Diseases and Urology (NIKDU), Dhaka, Bangladesh; 2Research Divission, BIRDEM, Dhaka, Bangladesh; 3Chemistry, Dhaka University, Dhaka, Bangladesh; 4Nephrology, BSM Medical University, Dhaka, Bangladesh

M303 INFLUENCE OF THE GENOTYPES OF ANGIOTENSIN CONVERTING ENZYME AND APOLIPOPROTEIN E ON PROGRESSION OF DIABETIC NEPHROPATHY Nicola Joss,1 J. Michael Boulton-Jones,1 Dariena Gaffney,2 Alan Jardine.3 1Renal Unit, Glasgow Royal Infirmary, Glasgow, Scotland, United Kingdom; 2Genetic Laboratory, Department of Pathological Biochemistry, Glasgow University, Glasgow, Scotland, United Kingdom; 3Renal Unit, Western Infirmary, Glasgow, Scotland, United Kingdom

M304 THE C-106T POLYMORPHISM IN PROMOTER OF ALDOSE REDUCTASE GENE IS RISK FACTOR FOR DIABETIC NEPHROPATHY IN TYPE 2 DIABETES PATIENTS WITH BAD GLYCAEMIC CONTROL Katarzyna Gosek, Dariusz Moczulski, Ewa Zukowska- Szczechowska, Wladyslaw Grzeszczak. Internal Medicine, Diabetology and Nephrology, Silesian School of Medicine, Zabrze, Poland TH MONDAY JUNE 9 POSTERS

M305 ASSOCIATION OF ALDEHYDE DEHYDROGENASE 2 Glu487Lys POLYMORPHISM WITH DIABETIC NEPHROPATHY Masaru Shoji,1 Shoji Tsutaya,2 Minoru Yasujima.1 1Department of Laboratory Medicine, Hirosaki University School of Medicine, Hirosaki, Aomori, Japan; 2Department of Clinical Laboratory, Hirosaki University Hospital, Hirosaki, Aomori, Japan

M306 PROTEOMIC ANALYSIS OF TYPE 1 AND TYPE 2 DIABETIC KIDNEYS: A PROMISING TOOL TO EXPLORE NOVEL MECHANISMS OF DIABETIC NEPHROPATHY Visith Thongboonkerd,1 Kenneth McLeish,1,2,5 Michelle Barati,1 Shirong Zheng,3,4 William Pierce,3 Paul Epstein,3,4 Jon Klein.1,2,5 1Core Proteomics Lab, Kidney Disease Program, Dept Med, 2Dept Biochemistry & Molecular Biology, 3Dept Pharmacology & Toxicology, 4Dept Pediatrics, Univ Louisville, Louisville, KY, USA; 5VAMC, Louisville, KY, USA

M307 INCREASED RESISTIN BLOOD LEVELS ARE NOT ASSOCIATED WITH INSULIN RESISTANCE IN PATIENTS WITH RENAL DISEASE Jan T. Kielstein, Björn Becker, Susanne Graf, Hermann Haller, Danilo Fliser. Nephrology, Medical School Hannover, Hannover, Germany

M308 RELATIONSHIP BETWEEN DIABETES, RENAL IMPAIRMENT AND ANAEMIA IN THE GENERAL POPULATION Steven Chadban,1,2 Esther Briganti,3 Paul Zimmet,4 Robert Atkins.1 1Nephrology, Monash Medical Centre, Melbourne, VIC, Australia; 2Renal Medicine, Royal Prince Alfred Hospital, Sydney, NSW, Australia; 3Epidemiology, Monash University, Melbourne, VIC, Australia; 4International Diabetes Institute, Melbourne, VIC, Australia

M309 RENAL BIOPSY IN DIABETES: CAN WE IMPROVE OUR PRACTICE? Satishkumar Jayawardene, Neil Sheerin. Department of Nephrology and Transplantation, Guy’s Hospital, King’s College London, London, United Kingdom

M310 SPECTRUM OF KIDNEY AND SYSTEMIC INVOLVEMENT IN ADULT PATIENTS WITH MUTATIONS IN THE HEPATOCYTE NUCLEAR FACTOR-1beta (HNF-1b) AND MATURITY-ONSET DIABETES OF THE YOUNG TYPE 5 (MODY5) Dominique Chauveau,1 Christine Bellanné-Chantelot,2 Laure-Hélène Noël,1 Danièle Dubois-Laforgue,1 Jean-François Gautier,3 Christian Boitard,1 José Timsit.1 1Service de Néphrologie, Diabétologie et INSERM U507, Hôpital Necker, Paris, France; 2CEPH, Hôpital Saint-Louis, Paris, France; 3Service d’Endocrinologie, Hôpital Saint Louis, Paris, France

M311 TUBULAR URATE EXCRETION IN DIABETES MELLITUS TYPE 2 Vlastimir Vlatkovic,1 Biljana Stojimirovic,2 Radmila Obrenovic,3 Dejan Petrovic.4 1International Dialysis Center, Banja Luka, ; 2Institut Urology and Nephrology,3Inst Biochemistry, Clinical Center of Serbia, Belgrade, Serbia, Yugoslavia; 4Dept. Nephrology, Clinical Center Kragujevac, Kragujevac, Serbia, Yugoslavia

M312 INFLAMMATORY PARAMETERS ARE INDEPENDENT PREDICTORS OF URINARY ALBUMIN EXCRETION IN TYPE 2 DIABETES MELLITUS Juan Navarro, Carmen Mora, Manuel Macía, Antonio Rivero, Eduardo Gallego, María Luisa Méndez, Jesús Chahin, Javier García. Nephrology Service, Hospital Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Tenerife, Spain POSTERS MONDAY JUNE 9TH

M313 PROGRESSION FROM NORMO- TO MICROALBUMINURIA IN DIABETIC PATIENTS IS ASSOCIATED WITH AN INCREASE IN IMMUNO-UNREACTIVE ALBUMIN Wayne Comper,1 Tanya Osicka,2 Richard MacIsaac,2 George Jerums.2 1Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia; 2Endocrine Unit, Austin & Repatriation Medical Centre, Heidelberg, Victoria, Australia

M314 VARIATION IN URINARY ALBUMIN DETECTED BY CONVENTIONAL IMMUNOASSAYS AND HIGH PERFORMANCE LIQUID CHROMATOGRAPHY Wayne Comper,1 George Jerums,2 Tanya Osicka.1 1Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia; 2Endocrine Unit, Austin & Repatriation Medical MONDAY Centre, Heidelberg, Victoria, Australia

M315 HIGH PREVALENCE OF IMMUNO-UNREACTIVE ALBUMIN IN URINE FROM DIABETIC PATIENTS WITH LOW GLOMERULAR RATE AND NORMOALBUMINURIA AS MEASURED BY CONVENTIONAL IMMUNOASSAY Wayne Comper,1 Tanya Osicka,1 Richard MacIsaac,2 George Jerums.2 1Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia; 2Endocrine Unit, Austin & Repatriation Medical Centre, Heidelberg, Victoria, Australia

M316 SCREENING TESTS EVALUATION FOR MICROALBUMINURIA IN DIABETES MELLITUS Katjusha Bakallbashi,1 Luljeta Cakerri,2 Elizana Petrela,3 Alma Idrizi,4 Myftar Barbullushi,4 Alketa Koroshi,4 Margarita Gjata.4 1Department of Biochemistry, UHC "Mother Teresa"Tirana, Albania; 2Department of Endocrinology, UHC "Mother Teresa"Tirana, Albania; 3Department of Biostatistique, UHC "Mother Teresa"Tirana, Albania; 4Department of Nephrology, UHC "Mother Teresa"Tirana, Albania

M317 DETECTION OF EARLY RENAL FAILURE IN DIABETES MELLITUS TYPE 2 PATIENTS ON A PRIMARY HEALTH-CARE SYSTEM Laura Cortes-Sanabria,1 Ramon Martinez-Ramirez,1 Enrique Rojas- Campos,1 Jose Canales,1 Josefina Hernandez,2 Graciela Barragan,3 Gilberto Alfaro,4 Jorge Flores,5 Moises Anaya,5 Alfonso Cueto- Manzano.1 1Unidad de Investigacion Medica en Epidemiologia Clinica, Hospital Especialidades, CMNO, IMSS, Guadalajara, Jalisco, Mexico; 2Laboratorio Central, Hospital Especialidades, CMNO, IMSS, Guadalajara, Jalisco, Mexico; 3Unidad Medicina Familiar 3, IMSS, Guadalajara, Jalisco, Mexico; 4Unidad Medicina Familiar 92, IMSS, Guadalajara, Jalisco, Mexico; 5Unidad Medicina Familiar 93, IMSS, Tonala, Jalisco, Mexico

M318 CONCENTRATIONS OF THE EARLY GLYCATED ADDUCT FUROSINE IN THE RANGE DETECTED IN PATIENTS IN HEMODIALYSIS OR PERITONEAL DIALYSIS, WITH OR WITHOUT DIABETES, SIMILARLY ENHANCE NITRIC OXIDE SYNTHASE AND APOPTOSIS OF ENDOTHELIAL CELLS Giovanni Conti, Alessandro Amore, Paola Cirina, Alessandra Mollo, Rosanna Coppo. Nephrology Dialysis Transplantation, Regina Margherita Children’s Hospital, Torino, Italy TH MONDAY JUNE 9 POSTERS

M319 SERUM LIPID PEROXIDATION & Na-K ATPase ACTIVITY IN MICROALBUMINURIC TYPE 2 DIABETICS AND EFFECT OF LOSARTAN Anupam Prakash,1 Samir Kubba,1 Satish K. Agarwal,1 Narinder P. Singh,1 Nirupam Prakash,1 Rashmi Babbar,2 B. Talukdar,3 Aruna Nigam,1 Vinod Puri.4 1Medicine, Maulana Azad Medical College, Delhi, India; 2Physiology, Maulana Azad Medical College, Delhi, India; 3Biochemistry, Maulana Azad Medical College, Delhi, India; 4Neurology, Maulana Azad Medical College, Delhi, India

M320 EVIDENCE FOR INCREASED OXIDATIVE STRESS IN THE RENAL VASCULATURE OF PATIENTS WITH TYPE 2 DIABETES Christian Delles, Markus P. Schneider, Sebastian Oehmer, Stefan John, Ingrid Fleischmann, Roland E. Schmieder. Department of Medicine IV, University of Erlangen-Nürnberg, Erlangen, Germany

M321 CORRELATION OF MICROALBOUMINURIA AND PLASMA HDL- C LEVELS IN PATIENTS WITH UNCONTROLLED TYPE II DIABETES MELLITUS George Rammos, Paraskeyi Tseke, Stauroula Ziakka, Philipos Karakasis. 1Internal Medicine Department, General Hospital of Nauplion, Nauplion, Greece; 2Nephrology Department, Corgialenio Benakio Hospital, Athens, Grenada

M322 ROLE OF DYSLIPIDEMIA ON RENAL FUNCTION IN PATIENTS WITH METABOLIC SYNDROME Z. Zhu,1 Y. Jin,1 Z. Yan,1 Z. Zhao,1 F. Zhou,1 M. Tepel.2 1Department of Hypertension and Endocrinology, University of Chongqing, Chongqing, China; 2Med. Klinik IV, Univ.-Klinik Benjamin Franklin, Berlin, Germany

M323 PLASMA HOMOCYSTEINE AND INSULIN LEVELS IN DIABETIC NEPHROPATHY AND THEIR RELATIONSHIP TO THE BODY MASS INDEX J.S. Sandhu, S.P. Aggarwal, A.P.S. Narang, Inderpal Singh, P. Sandhu. Nephrology, Dayanand Medical College & Hospital, Ludhiana, Punjab, India

M324 IMPACT OF AORTIC VALVE CALCIFICATION IN CARDIAC DEATH FOR JAPANESE TYPE 2 DIABETIC PATIENTS DURING END-STAGE RENAL DISEASE THERAPY Asako Sato, Tomoko Nakagami, Tetsuya Babazono, Yasuhiko Iwamoto. Diabetes Center, Tokyo Women’s Medical University, Tokyo, Japan

M325 CHANGES IN REGIONAL ARTERIAL STIFFNESS IN PATIENTS WITH DIABETIC NEPHROPATHY Eiji Kimoto,1 Tetsuo Shoji,1 Kayo Shinohara,1 Hidenori Koyama,1 Masanori Emoto,1 Eiji Ishimura,2 Yoshiki Nishizawa.1 1Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan; 2Department of Nephrology, Osaka City University Graduate School of Medicine, Osaka, Japan

M326 DIABETES IS THE MAJOR RISK FACTOR FOR CORONARY ATHEROSCLEROSIS IN URAEMIA Fabio Fabbian,1 Giuseppe Cacici,2 Paolo Benussi,2 Lucia Cavallini,1 Vittorio Ortalda,1 Carmelo Loschiavo,1 Giuseppe Maschio.1 1Nephrology, 2Cardiology, Ospedale Civile Maggiore, Verona, Italy POSTERS MONDAY JUNE 9TH

M327 EFFECTS OF URINARY ALBUMIN ON CARDIOVASCULAR PARAMETERS IN DIABETIC PATIENTS Yasuko Nakamura, Tadashi Morimura, Hidenori Matsuo. Internal Medicine, Maebashi Red Cross Hospital, Maebashi, Gunma, Japan

M328 ISCHEMIC RENAL DISEASE IN TYPE 2 DIABETES MELLITUS – PATIENTS IN GREAT RISK Plamen Yovchevski, Vladimir Paskalev, Valentina Mladenova, Nikolai Lazov, Marin Angelov. Nephrological Ward, Central Clinical Hospital, Sofia, Bulgaria

M329 DIABETES MELLITUS (DM) AND ANEMIA: THE IMPORTANCE OF A STRICT METABOLIC CONTROL Giuseppe Baldassarre, Giuseppe De Ruggieri, Mario Giannetto, Anna MONDAY Latorre, Tiziana Piccolo, Luigi Francesco Morrone, Alfonso Ramunni, Pasquale Coratelli. Depatment of Internal and Public Medicine, Division of Nephrology University, Bari, Italy

M330 LONG-TERM PREVENTION OF IMPAIRMENT IN RENAL FUNCTION IN PATIENTS WITH INSULIN-TREATED DIABETES MELLITUS Ralf Schiel,1 Sybille Franke,1 Ulrich A. Müller,2 Günter Stein.1 1Dept.Int.Med.IV, Univ. of Jena Med. School, Jena, Germany; 2Dept.Int.Med.II, Univ. of Jena Med. School, Jena, Germany

M331 HYPEROSMOLAR NON-KETOTIC HYPERGLYCEMIA (HONK): FACTORS INFLUENCING THE OUTCOME Nicholas Kaloudis, Christos Carvounis. Medicine, Nassau University Medical Center, East Meadow, NY, United States

M332 FAVOURABLE EFFECT OF DIETARY PROTEIN RESTRICTION ON PROGNOSIS IN TYPE 1 DIABETIC PATIENTS WITH DIABETIC NEPHROPATHY Lubomir Silan,1 Katarina Cerna,2 Emilia Urbanova,3 Gustav Kovac,4 Silvester Krcmery,5 Rudolf Hutar.6 1Third Dept. of Internal Medicine, Derer s University Hospital,Comenius University School of Medicine, Bratislava, Slovakia (Slovak Republic); 2First Department of Internal Medicine, Derer s University Hospital, Bratislava, Slovakia (Slovak Republic); 3Third Dept. of Internal Medicine, Derer s University Hospital, Bratislava, Slovakia (Slovak Republic); 4Dept.ofClinic. Biochemistry and Laborat.Medicine, Derer s University Hospital, Bratislava, Slovakia (Slovak Republic); 5Department of Geriatric Medicine, Derer s University Hospital, Bratislava, Slovakia (Slovak Republic); 6Third Department of Internal Medicine, Derer s University Hospital, Bratislava, Slovakia (Slovak Republic)

M333 EFFECTS OF PENTOXIFYLLINE IN DIABETIC NEPHROPATHY Renata Pantoja, Viktoria Woronik, Rui Barros. Nephrology, Hospital das Clinicas USP, Sao Paulo, Brazil

M334 EFFECT OF DUAL BLOCKADE OF RENIN-ANGIOTENSIN SYSTEM ON PROTEINURIA Aris Efstratopoulos, Sofia Siasiakou, Athanasios Baltas, Sofia Voyaki, Leonidas Mourgos, Vassilios Lekakis, Anastasios Hadzis, Theodoros Gialernios. 3rd Medical & Hypertension Unit, General Hospital of Athens “ G. Gennimatas”Athens, Attica, Greece

M335 EFFECT OF LOSARTAN ON ALBUMINURIA & NEUROPATHY IN NORMOTENSIVE MICROALBUMINURIC TYPE 2 DIABETICS Anupam Prakash, Aruna Nigam, Samir Kubba, Satish K. Agarwal, B. Talukdar, Vinod Puri, Rashmi Babbar, Narinder P. Singh. Medicine, Maulana Azad Medical College, Delhi, India TH MONDAY JUNE 9 POSTERS

M336 LOSARTAN TREATMENT EFFECT ON RENAL OUTCOMES IN TYPE 2 DIABETIC PATIENTS WITH NEPHROPATHY AFTER ADJUSTING FOR AN IMBALANCE IN BASELINE PROTEINURIA Shahnaz Shahinfar,1 Barry M. Brenner,2 Carl Erik Mogensen,3 Denise Ramjit,1 Gilbert Gleim,1 Dick de Zeeuw,4 William F. Keane,1 Zhongxin Zhang.1 1Clinical Research, Merck & Co., Inc., West Point, PA, United States; 2Renal Division, Brigham and Women’s Hospital, Boston, MA, United States; 3Medical Department M, Aarhus University Hospital, Aarhus, Denmark; 4Clinical Pharmacology, University of Groningen, Groningen, Netherlands

M337 EFFECTS OF ANGIOTENSIN CONVERTING ENZYME INHIBITOR ON PROTEINURIA AND RENAL FUNCTION IN PATIENTS WITH TYPE 2 DIABETES WITH OR WITHOUT RENAL FAILURE H.U. Rashid,1 M.N. Hassan,1 L. Ali.2 1Department of Nephrology, BSMMU, Dhaka, Bangladesh; 2Department of Biomedical Science, BIRDEM, Dhaka, Bangladesh

M338 THE IMPACT OF LOSARTAN ON THE LIFETIME INCIDENCE OF END-STAGE RENAL DISEASE AND ASSOCIATED COSTS: IMPLICATIONS FOR SINGAPORE GENERAL HOSPITAL BASED ON THE RENAAL STUDY K.S. Wong,1 W.C. Gerth,2 H.L. Choong,1 K.M. Yong,1 G.W. Carides,2 B.M. Brenner,3 K.T. Woo.1 1Department of Renal Medicine, Singapore General Hospital, Outram Road, Singapore; 2Merck & Co, Whitehouse Station, New Jersey, NJ, United States; 3Division of Nephrology, Brigham and Women’s Hospital, Boston, MA, United States

M339 COMPARATIVE EVALUATION AND ESTIMATION OF EFFICACY OF DIFFERENT COMBINATIONS OF HYPOTENSIVE PREPARATIONS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS, HYPERTENSION AND DIABETIC NEPHROPATHY Yekaterina Onuchina,1 Sergey Onuchin.2 1Internal Medicine Department 2, Kirov State Medical Academy, Kirov, Kirov Region, Russian Federation; 2Internal Medicine Department, Kirov State Medical Academy, Kirov, Kirov Region, Russian Federation

M340 PECULIARITIES OF CLINICAL EFFICACY OF ANGIOTENSIN CONVERTING ENZYME (ACE) INHIBITORS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS (DM) ASSOCIATED WITH ARTERIAL HYPERTENSION (AH) AND COMPLICATED BY DIABETIC NEPHROPATHY (DN) Sergey Onuchin,1 Yekaterina Onuchina,2 Maria Shulaeva.3 1Internal Medicine Department, Kirov State Medical Academy, Kirov, Kirov Region, Russian Federation; 2Internal Medicine Department 2, Kirov State Medical Academy, Kirov, Kirov Region, Russian Federation; 3Internal Medicine Department, Kirov State Medical Academy, Kirov, Kirov Region, Russian Federation

M341 EFFECT OF PERINDOPRIL AND IT’S COMBINATION WITH VERAPAMIL ON ARTERIAL RENAL BLOOD FLOW VELOCITY AND PROTEINURIA IN TYPE 1 DIABETIC PATIENTS WITH OVERT NEPHROPATHY Vladimir Dobronravov, Alexander Karpov. Institute of Nephrology, Saint-Petersburg Pavlov State Medicl University, Saint-Petersburg, Russian Federation

M342 URINARY N-ACETYL-b-GLUCOSAMINIDASE EXCRETION IN TYPE 2 DIABETES MELLITUS. EFFECT OF PENTOXIFYLLINE ADMINISTRATION Juan Navarro, Carmen Mora, Manuel Macía, Antonio Rivero, Eduardo Gallego, María Luisa Méndez, Jesús Chahin, Javier García. Nephrology Service, Hospital Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Tenerife, Spain POSTERS MONDAY JUNE 9TH

M343 INTENSIFIED TREATMENT OF PATIENTS WITH TYPE 2 DIABETES MELLITUS AND OVERT NEPHROPATHY – RENAL AND VASCULAR CONSEQUENCES Nicola Joss, J. Michael Boulton-Jones, Caroline Ferguson, Christine Brown, Christopher Deighan. Renal Unit, Glasgow Royal Infirmary, Glasgow, Scotland, United Kingdom

M344 SCREENING FOR RENAL ANEMIA IN A DISEASE MANAGEMENT PROGRAMME FOR DIABETES MELLITUS Ruediger Landgraf,1 Johann Fahn,2 Rolf Renner.3 1Diabetes Centre, University of Munich, Munich, Germany; 2Health Care Professional, Munich, Germany; 3Diabetes Centre, Hospital Munich-Bogenhausen, Munich, Germany MONDAY

M345 COMPARISON OF DIALYTIC THERAPY OF TYPE 1 AND TYPE 2 DIABETES MELLITUS IN ITALY: A NATIONAL EPIDEMIOLOGICAL STUDY Giovanni Panzetta,1 Enzo Ancarani,2 Antonio Santoro,3 Carlo Vasile,4 Giuseppe Verzetti.5 1Study Group for the Survey of Diabetes and Dialysis, Division of Nephrology and Dialysis, Trieste, Italy; 2Viterbo, Italy; 3Bologna, Italy; 4Martina Franca, Italy; 5Novara, Italy

M346 METABOLISM AND NUTRITIONAL STATUS IN DIABETIC PATIENTS ON DIALYSIS IN ITALY: RESULTS OF THE NATIONWIDE SURVEY “REPLACEMENT THERAPY IN THE END- STAGE DIABETIC NEPHROPATHY” (TESONEDIT) Enzo Ancarani,1 Stefano Costantini,1 Giovanni Panzetta,2 Marcello Borghi,3 Carlo Basile,4 Antonio Santoro,5 Francesco Guarnieri,6 Carlo Navino,7 Giuseppe Verzetti.7 1Department of Nephrology, Hospital of Viterbo; 2Nephrology and Dialysis Unit, Cattinara Hospital, Trieste; 3Nephrology and Dialysis Unit, Hospital of Treviglio; 4Division of Nephrology, Hospital of Martina Franca; 5Malpighi Nephrology and Dialysis Unit, Policlinico S.Orsola-Malpighi, Bologna; 6Hospal S.p.A, Bologna; 7Division of Nephrology Dialysis and Transplant, Maggiore della Carità Hospital, Novara

M347 IS THERE A CHANGE IN THE COURSE OF DIABETIC NEPHROPATHY? LESSONS FROM 28 YEARS OF RENAL TRANSPLANTATION IN PATIENTS WITH TYPE 1 DIABETES MELLITUS (DM) Claude Cao,1 Markus Weber,2 Jens Hellermann,3 Patrice Ambuehl.1 1Renal Division, University Hospital, Zurich, Switzerland; 2Department of Transplant Surgery, University Hospital, Zurich, Switzerland; 3Cardiology Division, University Hospital, Zurich, Switzerland

M348 LONG-TERM SURVIVAL OF DIABETIC PATIENTS TREATED WITH DIALYSIS THERAPY - A HOSPITAL-BASED 25-YEAR- FOLLOW-UP STUDY- Tetsuya Babazono, Osamu Tomonaga, Aiko Inoue, Nobue Tanaka, Yumiko Sakka, Ken Sato, Akiko Ishii, Michiyo Hase, Masanobu Takeda, Yasuko Takano, Chieko Takahashi, Noriko Ujihara, Yasuhiko Iwamoto. Diabetes Center, Tokyo Women’s Medical University School of Medicine, Tokyo, Japan

M349 DIABETES MELLITUS AND DIALYSIS IN ITALY: A NATIONAL EPIDEMIOLOGICAL STUDY Giuseppe Verzetti,1 Enzo Ancarani,2 Giovanni Panzetta,3 Antonio Santoro,4 Carlo Vasile.5 1Study Group for the Survey of Diabetes and Dialysis, Division of Nephrology and Dialysis, Novara, Italy; 2Viterbo, Italy; 3Trieste, Italy; 4Bologna, Italy; 5Martina Franca, Italy TH MONDAY JUNE 9 POSTERS

M350 INFLUENCE OF CHRONIC KIDNEY DISEASE ON HEALTH- RELATED QUALITY OF LIFE IN DIABETIC PATIENTS Yumiko Sakka, Tetsuya Babazono, Aiko Inoue, Nobue Tanaka, Akiko Ishii, Ken Sato, Michiyo Hase, Masanobu Takeda, Osamu Tomonaga, Noriko Ujihara, Takamichi Shinjo, Chieko Takahashi, Yasuhiko Iwamoto. Diabetes Center, Tokyo Women’s Medical University School of Medicine, Tokyo, Japan POSTERS MONDAY JUNE 9TH

TUBULOINTERSTITIAL RENAL DISEASES, URINARY TRACT INFECTION, UROLITHIASIS

M351 CALCIUM SENSING RECEPTOR ACTIVATION INHIBITS FORSKOLIN-INDUCED AQP2 TARGETING IN RENAL CELLS Giuseppe Procino, Monica Carmosino, Grazia Tamma, Sabine Gouraud, Antonella Laera, Maria Svelto, Giovanna Valenti. Department of General and Environmental Physiology, University of Bari, Bari, Italy

CRYSTAL RETENTION IN KIDNEYS OF HYPEROXALURIC RATS:

M352 MONDAY CRYSTALS ADHERE TO SUBLETHALLY DAMAGED TUBULAR EPITHELIAL CELLS EXPRESSING HYALURONAN, CD44 AND OSTEOPONTIN AT THEIR LUMINAL SURFACE M. Asselman,1,3 A. Verhulst,2,3 C.F. Verkoelen,1 M.E. De Broe.2 1Dept. of Urology, Erasmus MC Rotterdam, Netherlands; 2Dept. of Nephrology-Hypertension, University of Antwerp, Belgium; 3The First Two Authors Contributed Equally to This Work

M353 IS A TREATMENT WITH OXALOBACTER FORMIGENES A NEW THERAPEUTIC OPTION IN PATIENTS WITH PRIMARY HYPEROXALURIA (PH)? Bernd Hoppe,1 Albrecht Hesse,2 Gerd von Unruh,3 Bodo Beck,1 Matthias Schmidt,2 Harmeet Sidhu.4 1Department of Pediatrics, University Hospital Cologne, Cologne, Germany; 2Department of Urology, University Hospital Bonn, Bonn, Germany; 3Department of Internal Medicine, University Hospital Bonn, Bonn, Germany; 4Urolithiasis Research, Ixion Biotechnology Inc., Alachua, FL, United States

M354 FREQUENCY OF RENAL PHOSPHATE LEAK AMONG PATIENTS WITH IDIOPATHIC HYPERCALCIURIA Armando L. Negri, Rodolfo Spivacow, Elisa Del Valle, Erik Fradinger, Jose R. Zanchetta. Nephrology, Instituto de Investigaciones Metabólicas, Buenos Aires, Argentina

M355 VITAMIN D RECEPTOR GENE POLYMORPHISM AND BONE MINERAL DENSITY IN HYPERCALCIURIC CHILDREN Ozan Ozkaya, Oguz Soylemezoglu, Sevim Gonen, Muge Misirlioglu, Serdar Tuncer, Necla Buyan, Suleyman Kalman. Pediatric Nephrology, Gazi University, Ankara, Turkey

M356 CALCIURIA IN PATIENTS WITH BETA-THALASSEMIA AND NEPHROLITHIASIS Stavroula Ziakka,1 George Tolis,2 Eleni Constandellou,2 Philippos Karakassis,1 Nicolaos Papagalanis.1 1Nephrology Department, Corgialenio Benakio Hospital, Athens, Greece; 2Endocrinology Department, Hippokratio Hospital, Athens, Greece

M357 BENEFICIAL EFFECT OF AMITRIPTYLINE ON UROLITHIASIS THROUGH URINARY TRACT SMOOTH MUSCLE RELAXATION Eduardo Achar,1 Rosi Achar,1 Terezinha Paiva,2 Alexandre Campos,1 Nestor Schor.1 1Medicine/Nephrology, Unifesp, Sao Paulo, Brazil; 2Biophysic, Unifesp, Sao Paulo, Brazil

M358 CEFTRIAXONE ASSOCIATED NEPHROLITHIASIS Masoumeh Mohkam,1 Mostafa Sharifian,1 Nozar Ghogevand,2 Hamid Khatibi.1 1Pediatric Nephrology, Shahid Beheshti University, Tehran, Islamic Republic of Iran; 2Pediatric Radiology, Shahid Beheshti University, Tehran, Islamic Republic of Iran TH MONDAY JUNE 9 POSTERS

M359 EFFECTS OF CALCIUM OXALATE CRYSTALS ON THE SYNTHESIS OF PROTEOGLYCANS AND GLYCOSAMINOGLYCANS IN TUBULAR EPITHELIAL CELLS (MDCK AND LLC–PK1) Fernanda T. Borges,1 Alexandre H. Campos,1 Yara M. Michelacci,2 Nestor Schor.1 1Medicine, Division of Nepfrology, UNIFESP, São Paulo, Brazil; 2Biochemistry, Division of Molecular Biology, UNIFESP, São Paulo, Brazil

M360 PRIMARY HYPERPARATHYROIDISM AND RISK FACTORS FOR KIDNEY STONE DEVELOPMENT Corbetta Sabrina,1 Baccarelli Andrea,2 Aroldi Adriana,3 Vicentini Leonardo,4 Fogazzi Gianbattista,3 Eller-Vainicher Cristina,1 Ponticelli Claudio,3 Beck-Peccoz Paolo,1 Spada Anna.1 1Institute of Endocrine Sciences, Institute of Endocrine Sciences, Milan, Italy; 2Division of Cancer Epidemiology & Genetics, Genetic Epidemiology Branch, NIH, DHHS, Bethesda, United States; 3Division of Nephrology, Ospedale Maggiore, Milan, Italy; 4Endocrine Surgery, Ospedale Maggiore, Milan, Italy

M361 THE TIMING OF TAKING CALCIUM SUPPLEMENT AND THE RISK OF NEPHROLITHIASIS Wasana Stitchantrakul,1 Wichai Sopassathit,2 Surasing Prapaipanich,3 Chatuporn Ruangraksa,1 Somnuek Domrongkitchaiporn,2 Rajata Rajatanavin.2 1Research Center, 2Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 3Medicine, Aparkornkietivong Hospital, Chonburi, Thailand

M362 MUTATIONAL ANALYSIS OF XANTHINE DEHYDROGENASE GENE IN A TURKISH FAMILY WITH AUTOSOMAL RECESSIVE CLASSICAL XANTHINURIA: EVIDENCE FOR STONE FORMATION IN HETEROZYGOUS INDIVIDUALS Rezan Topaloglu,1 Faysal Gok,2 Kimiyoshi Ichida.3 1Pediatric Nephrology and Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey; 2Pediatric Nephrology, Gulhane Military Medical School, Ankara, Turkey; 3Internal Medicine Division of Kidney and Hypertension, Jikei University School of Medicine, Tokyo, Japan

M363 EXPRESSION OF NUCLEAR PORE COMPLEX OXALATE BINDING PROTEIN P62 IN DIFFERENT KIDNEY DISORDERS Pichu Sivakamasundari, Ramasamy Selvam, Palaninathan Varalakshmi. Medical Biochemistry, Dr. ALM PGIBMS, University of Madras, Taramani Campus, Chennai, Tamil Nadu, India

M364 CRYSTAL BINDING CAPACITY OF CELLS IN THE HUMAN NEPHRON Anja Verhulst,1 Marino Asselman,2 Veerle P. Persy,1 Marieke S. Scheper,2 Carl F. Verkoelen,2 Marc E. De Broe.1 1Department of Nephrology, University of Antwerp, Belgium; 2Department of Urology, Erasmus Medical Center Rotterdam, Netherlands

M365 USEFULLNESS OF PROCALCITONIN FOR DIAGNOSIS OF PYELONEPHRITIS IN CHILDREN Shahnaz Armin,1 Sanaz Sasani,1 Masoumeh Mohkam.2 1Pediatric Infectious Diseases, Shahid Beheshti University, Tehran, Islamic Republic of Iran; 2Pediatric Nephrology, Shahid Beheshti University, Tehran, Islamic Republic of Iran POSTERS MONDAY JUNE 9TH

M366 URINARY PROCALCITONIN AS A MARKER OF ACUTE PYELONEPHRITIS AND VESICOURETERAL REFLUX Masoumeh Mohkam,1 Mostafa Sharifian,1 Behnaz Rohani,1 Shahnaz Armin,2 Fatemeh Gholikhani.1 1Pediatric Nephrology, Shahid Beheshti University, Tehran, Islamic Republic of Iran; 2Pediatric Infectious Diseases, Shahid Beheshti University, Tehran, Islamic Republic of Iran

M367 WAYS OF IMPROVEMENT OF DIAGNOSIS FOR MIXED INFECTIONS OF UPPER URINARY TRACT Oleg Zonov,1 Sergey Koshkin.2 1Therapy Department, Kirov State Medical Academy, Kirov, Kirov Region, Russian Federation; 2Dermatovenerology Department, Kirov State Medical Academy, Kirov Region, Kirov, Russian Federation MONDAY M368 THE EFFECTS OF NEONATAL SEVERE PARTIAL URETERAL OBSTRUCTION ON RENAL PELVIC PRESSURE AND RENAL MORPHOLOGY IN RATS Jian Guo Wen, Gui Xian Wang, Xi Mei Wang, Zhang Suo Liu, Jogen Frokiar, Jes Christmas Djurhuus. 1Department of Pediatric Urology and Nephrology, The First Teaching Hospital of Zhengzhou University, Zhengzhou City, Hannan, China; 2IEKF, Aarhus University, Aarhus, Denmark

M369 RENAL DYSFUNCTION AFTER RELIEF OF OBSTRUCTION IS SELDOM PROGRESSIVE Rommel Ravanan, Charles R.V. Tomson. Richard Bright Renal Unit, Southmead Hospital, Bristol, United Kingdom

M370 ACE GENE POLYMORPHISM AND RENAL SCARRING IN CHILDREN WITH VESICOURETERAL REFLUX Hakan Erdogan,1 Pelin Ertan,1 Nese Ozkayin,1 Afig Berdeli,2 Erkin Serdaroglu,1 Sevgi Mir,1 Alphan Cura.1 1Department of Pediatric Nephrology, Ege University Medical School, Izmir, TR, Turkey; 2Molecular Medicine Laboratory, Ege University Medical School, Izmir, TR, Tunisia

M371 EXPRESSION LEVELS OF ORGANIC ANION TRANSPORTERS AND THEIR CORRELATION WITH URINARY EXCRETION OF ANIONIC DRUGS IN PATIENTS WITH RENAL DISEASE Hideyuki Motohashi,1 Yuji Sakurai,1 Harumasa Ueo,1 Satohiro Masuda,1 Masahiro Okuda,1 Hideyuki Saito,1 Masahiro Okuda,1 Atsushi Fukatsu,2 Osamu Ogawa,3 Toshio Doi,4 Ken-ichi Inui.1 1Dept. of Pharmacy, Kyoto University Hospital, Kyoto, Japan; 2Dept. of Artificial Kidneys, Kyoto University Hospital, Kyoto, Japan; 3Dept. of Urology, Kyoto University Hospital, Kyoto, Japan; 4Dept. of Clinical Biology and Medicine, University of Tokushima, Tokushima, Japan

M372 RENAL SARCOIDOSIS: A CLINICOPATHOLOGICAL STUDY OF 38 PATIENTS Harsharan Singh,1 Surya Seshan,2 Cynthia Christiano,3 Melanie Hames,3 Mary Jane Barchman,3 Volker Nickeleit.1 1Lab Nephropathol, Univ North Carolina School of Medicine, Chapel Hill, NC, USA; 2Dept Pathol, Cornell Univ/New York Presbyterian Hosp, New York, NY, USA; 3Div Nephrol & Hypert, Dept Int Med, East Carolina Univ, Brody School of Med, Greenville, NC, USA

M373 UROTHELIAL CARCINOMA IN THE PATIENTS WITH CHRONIC ARISTOLOCHIC ACID NEPHROPATHY Wen Chen, YiPu Chen, An Li. Center of Nephrology, China-Japan Friendship Hospital, Beijing, China

M374 ONCOGENESIS STUDY IN RAT MODEL OF CHRONIC ARISTOLOCHIC ACID NEPHROPATHY YanLi Gao, WanZhong Zou, HongRui Dong, YiPu Chen. Center of Nephrology, China-Japan Friendship Hospital, Beijing, China TH MONDAY JUNE 9 POSTERS CLINICAL NEPHROLOGY: MISCELLANEOUS

M375 RESEARCH IN NEPHROLOGY: FEW INTERVENTION TRIALS, MANY BASIC SCIENCE PUBLICATIONS Giovanni F.M. Strippoli,1 Jonathan C. Craig,1,2 Francesco P. Schena.3 1Centre for Kidney Research, Cochrane Renal Group-Children’s Hospital at Westmead, NSW, Australia; 2School of Public Health, University of Sydney, Australia; 3Department of Emergency and Organ Transplantation, University of Bari, Italy

M376 WHAT LABORATORY TESTS ARE RELIABLE TO DETERMINE THE BASIS FOR HYPOKALEMIA AND PARALYSIS? Shih-Hua Lin, Yu-Juei Hsu, Pauling Chu, Yuh-Feng Lin. Division of Nephrology, Department of Medicine, Tri-Service General Hospital, Taipei, Taiwan

M377 SALBUTAMOL (b1 AGONIST) NEBULIZATION - AN EFFECTIVE METHOD FOR MANAGEMENT OF HYPERKALEMIA Narasimhamurthy Rajagopal,1 K.S. Nayak.2 1Medicine, Railway Hospital, Secunderabad, Andhra Pradesh, India; 2Nephrology, Global Hospitals, Hyderabad, Andhra Pradesh, India

M378 DIFFERENCE IN CLINICAL CHARACTERISTICS OF DISORDERS FEATURING LOW RENIN ACTIVITY BETWEEN MINERALOCORTICOID-RESPONSIVE HYPONATREMIA OF THE ELDERLY (MRHE) AND RENAL TUBULAR ACIDOSIS (RTA) VI Aki Ikoma, Tomoyuki Saito, Masami Sasaki, Hiroyuki Tamemoto, Keizo Kasono, Masanobu Kawakami, San-e Ishikawa. Department of Medicine, Jichi Medical School Omiya Medical Center, Saitama, Japan

M379 MINERALOCORTICOID-RESPONSIVE HYPONATREMIA OF THE ELDERLY (MRHE): CLINICAL ENTITY FORWARDING DIAGNOSIS AND TREATMENT OF HYPONATREMIA IN ELDERLY San-e Ishikawa, Hiroshi Funayama, Tomohiro Nakamura, Tomoyuki Saito, Masami Sasaki, Keizo Kasono, Hiroyuki Tamemoto, Masanobu Kawakami. Department of Medicine, Jichi Medical School Omiya Medical Center, Amanuma, Saitama, Japan

M380 RENAL EFFECTS OF CELECOXIB AND ROFECOXIB IN NORMAL SUBJECTS AT LOW SODIUM DIET Giulio Romano,1 Edmondo Falleti,2 Nicoletta Franzolini,1 Fabio Gonano,2 Gianfranco Ferraccioli.1 1Nephrology Unit-Division of Rheumatology, DPMSC, Univerity of Udine, Udine, Italy; 2Central Laboratory-Chair of Clinical Pathology, DPMSC, Univerity of Udine, Udine, Italy

M381 TAMOXIFEN VS PREDNISONE IN PATIENTS WITH RETROPERITONEAL FIBROSIS: PRELIMINARY RESULTS OF A RANDOMISED CLINICAL TRIAL Augusto Vaglio,1 Lucio Manenti,1 Francesco Ferrozzi,2 Giuseppe Tognini,2 Paolo Greco,1 Carlo Buzio.1 1Clinical Medicine and Nephrology, University of Parma, Parma, Italy; 2Department of Radiology, University of Parma, Parma, Italy

M382 DRUG RELATED RETROPERITONEAL FIBROSIS (RPF) REPORT OF 5 CASES Soumaya Beji, Hayet Kaaroud, Hafedh Hedri, Fatma Ben Moussa, Rym Goucha, Ezzeddine Abderrahim, Fethi Ben Hamida, Sami Turki, Fethi Elyounsi, Hedi Ben Maiz. Nephrology and Internal Medicine, Charles Nicolle Hospital, Tunis, Tunisia POSTERS MONDAY JUNE 9TH

M383 BIOCHEMICAL SAFETY AND EFFICACY OF CO- ADMINISTRATION OF EZETIMIBE AND SIMVASTATIN AMONG PATIENTS WITH CHRONIC KIDNEY DISEASE: THE SECOND UK-HEART AND RENAL PROTECTION (UK-HARP-II) STUDY Martin Landray, Colin Baigent, Craig Leaper, the UK-HARP Steering Committee. Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom

M384 DIFFERENT EFFECTS OF ISOLATED RAYNAUD SYNDROME AND SCLERODERMA ON FUNCTIONAL WALL PROPERTIES OF LARGE ARTERIES Markus Kosch,1 Hendrik Oen,1 Markus Gaubitz,1 Stefan Grabbe,2 Michael Barenbrock,1 Karl-Heinz Rahn,1 Martin Hausberg.1 1Department of Internal Medicine D, UKM, University of Münster, MONDAY Münster, Germany; 2Department of Dermatology, UKM, University of Münster, Münster, Germany

M385 DECREASED EXPRESSION OF NOVEL MEMBER OF ALPHA CLASS GLUTATHIONE S-TRANSFERASES IN PATIENTS WITH RENAL CELL CARCINOMA Tatjana Simic,1 Jasmina Mimic-Oka,1 Dejan Dragicevic,2 Ana Savic Radojevic,1 Marija Pljesa,1 Katarina Ille,1 Majda Hadziahmetovic.1 1Institute of Biochemistry, Faculty of Medicine, Belgrade, Serbia, Yugoslavia; 2Institute of Urology, Clinical Centre Serbia, Belgrade, Serbia, Yugoslavia

M386 SENSITIVE IDENTIFICATION OF SPECIFIC T-CELL IMMUNITY TOWARDS M. TUBERCULOSIS IN IMMUNOCOMPROMISED PATIENTS BY THE USE OF A RAPID FLOW-CYTOMETRIC WHOLE-BLOOD ASSAY Martina Sester,1 Urban Sester,1 Peter Clauer,1 Gunnar H. Heine,1 Thomas Moll,2 Ulrich Mack,3 Gerhard W. Sybrecht,3 Hans Köhler.1 1Medical Department IV, University of the Saarland, Homburg, Germany; 2Medical Department II, University of the Saarland, Homburg, Germany; 3Medical Department V, University of the Saarland, Homburg, Germany

M387 PHARMACOKINETICS OF THE SELECTIVE ESTROGEN RECEPTOR MODULATOR RALOXIFENE IN MALE VOLUNTEERS WITH RENAL IMPAIRMENT Frieder Keller, Mette Heringa, David Czock. Nephrology, Internal Medicine II, University Hospital, Ulm, Germany

M388 SURGICAL THERAPY OF THE ADULT NUTCRACKER PHENOMENON: LONG-TERM FOLLOW-UP Hongfeng Huang, Weiqin Lin, Jianghua Chen, Ming Li. The Nephrology Cenetr,the 1st Affiliated Hospital, Medical College,Zhejiang University, Hangzhou, Zhejiang, China

M389 FACIAL ASYMMETRY IN RENAL DISEASES Rajaratnam Krishnan, Ranjit Narayanan, Jyotish Cg, Jayakumar , T.P. Naushad. Nephrology, Medical College Hospital, Calicut, Kerala, India

M390 ARE THE COX-2 INHIBITORS AS GOOD AS THEY WERE INITIALLY THOUGHT TO BE?? Munavvar Izhar, Amy Folker, George Bakris. Hypertension Section, Dept. of Preventive Medicine, Rush- Presbyterian-St.-Luke’s-Medical Center, Chicago, IL, United States

M391 MEDICAL EDUCATION: TEACHING GLOMERULONEPHRITIS USING THE MULTIMEDIA ONLINE SYSTEM LAMEDICA Nicole Kadlec,1 Christian Aymanns,1 Beate Lindemann,1 Silke Huettner,1 Reinhard Friedl,2 Frieder Keller,1 Sylvia Stracke.1 1Nephrology, University Hospital, Ulm, Germany; 2Cardiac Surgery, University Hospital, Ulm, Germany TH MONDAY JUNE 9 POSTERS

M392 EFFICACY OF VIAGRA IN PATIENTS WITH HYPERTENSION, DIABETES, HYPERCHOLESTEROLEMIA AND OTHER CO- MORBID CONDITIONS Munavvar Izhar,1 Farzana Izhar,2 Renee Ellis,1 Dilip Pandey,1 Henry Black.1 1Hypertesion Section, Dept. of Preventive Medicine, Rush- Presbyterian-St.-Luke’s-Medical Center, Chicago, IL, United States; 2Internal Medicine, Saint Bernard Hospital and Medical Center, Chicago, IL, United States

M393 RENAL EMBOLISATION AS AN ALTERNATIVE TO NEPHRECTOMY: FIVE YEAR EXPERIENCE Dilip Kumar Pahari,1 R.N. Basu,2 Pratik Das.1 1Nephrology, N R S Medical College, Kolkata, West Bengal, India; 2Urology, AMRI, Kolkata, West Bengal, India; 3Nephrology, N R S Medical College, Kolkata, Wet Bengal, India

M394 COMMUNITY SCREENING PROGRAMME FOR KIDNEY DISEASE IN DELHI, INDIA- AN EPIDEMIOLOGIC ANALYSIS Narinder P. Singh, Anupam Prakash, Satish K. Agarwal. Nephrology Division, Department of Medicine, Maulana Azad Medical College, New Delhi, Delhi, India

M395 RHEONET-REGISTRY - RHEOPHERESIS SAFETY REPORT 2002/ 2003 Reinhard Klingel, Thurid Fassbender, Cordula Fassbender, Britta Goehlen, the German Rheopheresis Competence Centers. AFI, Apheresis Research Institute, Cologne, Germany POSTERS MONDAY JUNE 9TH

PROGRESSION

M396 PREDIALYSIS PATIENTS AT RISK OF EARLY NEED FOR RENAL REPLACEMENT THERAPY EleoNora M.C. Voormolen,1 Yvo W. Sijpkens,2 Femke van der Sman- de Beer,1 Elisabeth W. Boeschoten,3,4 Friedo W. Dekker.1 1Dept. of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands; 2Dept. of Nephrology, Leiden University Medical Center, Leiden, Netherlands; 3Dept. of Nephrology, Academic Medical Center, Amsterdam, Netherlands; 4DIANET Dialysis Centers, Academic Medical Center, Amsterdam, Netherlands MONDAY M397 NEPHROLOGICAL REFERRAL OF PATIENTS WITH CHRONIC RENAL FAILURE DETERMINES THE MORBIDITY AND THE CHOISE OF THE PERMANENT DIALYSIS TREATMENT Roberto Russo,1 Roberto Corciulo,2 Maria Strippoli,1 Pasquale Coratelli.1 1Division of Nephrology 1, University, Bari, Italy; 2Division of Nephrology 2, University, Bari, Italy

M398 BASELINE NEPHROLOGY REFERRAL DATA FROM THE CANADIAN CARE PRIOR TO DIALYSIS (CAN-CARE) STUDY Bryan Curtis,1 Brendan Barrett,1 Ognjenka Djurdjev,2 Adeera Levin,2 Canadian Renal Disease Alliance Group.3 1Patient Research Center, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; 2Nephrology, St. Paul’s Hospital, University of British Columbia, Vancouver, BC, Canada; 3CREDA, Canadian Renal Disease Alliance Group, Canada

M399 CHANGE OF REFERRAL PATTERN FOR CHRONIC DIALYSIS? Stefan Herget-Rosenthal,1 Christina Linden,1 Thomas Quellmann,2 Thomas Philipp,1 Andreas Kribben.1 1Dept. of Nephrology, 2Dept. of General Practice, University of Essen, Essen, Germany

M400 ENCOURAGING TIMELY SPECIALIST REFERRAL IN CHRONIC RENAL DISEASE Adrian Mondry,1 Ai Ling Zhu,1 Thuy Denise Vo,2 Kai Hahn.3 1Medical Informatics, Bioinformatics Institute, Singapore, Singapore; 2Frauenheilkunde und Geburtshilfe, Klinikum Solingen, Solingen, NRW, Germany; 3Nephrologie und Dialyse, Praxis Karl- Harr Strasse, Dortmund, NRW, Germany

M401 THE EPIDEMIOLOGY OF UNREFERRED CHRONIC RENAL FAILURE - A ONE YEAR PROSPECTIVE STUDY Ian John,1 Michelle Webb,1 Alan Young,2 Paul Stevens.1 1Department of Renal Medicine, Kent and Canterbury Hospital, Canterbury, Kent, United Kingdom; 2Department of Information Technology, William Harvey Hospital, Ashford, Kent, United Kingdom

M402 UREMIC PATIENTS - LATE REFERRAL, EARLY DEATH? Vedat Schwenger, Alex Hofman, Martin Zeier, Eberhard Ritz. Dep. Internal Medicine, Nephrology, University of Heidelberg, Heidelberg, Germany

M403 THE NEPHROLOGIST’S ROLE IN THE MANAGEMENT OF CALCIUM-PHOSPHORUS METABOLISM IN PATIENTS WITH CHRONIC KIDNEY DISEASE Wolfgang C. Winkelmayer, Raisa Levin, Jerry Avorn. Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women’s Hospital/Harvard Medical School, Boston, MA, United States TH MONDAY JUNE 9 POSTERS

M404 ASSOCIATION OF THE HUMAN B2-BRADYKININ RECEPTOR GENE WITH CHRONIC RENAL FAILURE Monika Buraczynska, Piotr Ksiazek, Wojciech Zaluska, Andrzej Ksiazek. Nephrology, University Medical School, Lublin, Poland

M405 ASSOCIATION BETWEEN THE TGF-b1 COD 10 POLYMORPHISM WITH CHRONIC RENAL INSUFFICIENCY AND HIGHER CARDIOVASCULAR RISK 1Elisabet Coll, 2Daniel González-Núñez, 3Begoña Campos, 4Albert Botey, 5Esteban Poch. 1Dept. of Nephrology, Hospital Clinic, Barcelona, Spain; 2Laboratory of Hormonal, Hospital Clinic, Barcelona, Spain; 3Dept. of Statistics, Faculty of Medicin.University of Barcelona, Barcelona, Spain; 4Dept. of Nephrology, Hospital Clinic, Barcelona, Spain; 5Dept. of Nephrology, Hospital Clinic, Barcelona, Spain

M406 POLYMORHISMS OF THE NITRIC OXIDE SYNTHASE GENE IN UREMIC PATIENTS Ferenc Papp,1 Zoltán Horváth,1 Csaba Bereczki,1 Ibolya Haszon,1 Éva Kiss,2 Emoke Endreffy,1 Sándor Túri.1 1Department of Pediatrics, University of Szeged, Szeged, Hungary; 2GAMBRO Dialysis Center, Szeged, Hungary

M407 END STAGE RENAL FAILURE AND APOLIPOPROTEIN E POLYMORPHISM: A SIGNIFICANT CLINICAL CORRELATION? Tick Seng Low, Wanda Seet, Jama Tan, Si Yen Tan. Renal Unit, Medical, University Malaya Medical Center, Kuala Lumpur, Wilayah Persekutuan, Malaysia

M408 ENDOTHELIN RECEPTORS IN PROTEINURIC AND NON- PROTEINURIC GLOMERULONEPHRITIDES Anastasios Drakopoulos, Sotiris Tsakas, Dimitrios Goumenos, Sotiria Alexandri, Pantelitsa Kalliakmani, John Vlachojannis. Internal Medicine - Nephrology, University Hospital, Patras, Greece

M409 URINARY GLUTATHIONE-S-TRANSFERASE (GST) ISOZYMES IN RENAL FAILURE - CAN THEY MAKE A DIFFERENCE Indira Agarwal, Paul Henning, Sandra Harris, Susan Conry. Renal Unit, Women and Children’s Hospital, Adelaide, South Australia, Australia

M410 INTRARENAL BLOOD FLOW PAREMETERS IN THE EVALUATION OF THE SEPARATED RENAL FUNCTION Rumyana Krasteva,1 Boryana Kiperova,1 Emil Andeev,1 Iren Kostadinova,2 Ani Simeonova,2 Todor Pertov.2 1Clinic of Nephrology, University Hospital “ Alexandrovska”Sofia, Bulgaria; 2Clinical Center of Nuclear Medicin, University Hospital “Alexandrovska”Sofia, Bulgaria

M411 EFFECT OF A NEW RENAL EDUCATION PROGRAMME ON KIDNEY FUNCTION AND RISK FACTORS IN PREDIALYSIS PATIENTS Jarmila Mahlmeister,1 Christoph Wanner,2 Emanuel Fritschka.1 1Nephrology, Sinntalklinik, Bad Brueckenau, Bayern, Germany; 2Nephrology, Universitaetsklinikum Wuerzburg, Wuerzburg, Bayern, Germany

M412 PATIENTS’ PERCEPTION OF THEIR KNOWLEDGE OF CHRONIC KIDNEY DISEASE AND DEVELOPMENT OF AN EDUCATIONAL PROGRAM Peter Juergensen,1,2,3 Diane Wuerth,1,2 Susan Finkelstein,1,2 Kathleen Rodd,1,2 Fredric Finkelstein.1,2,3 1Medicine, New Haven CAPD, New Haven, CT, United States; 2Medicine, Renal Research Institute, New York, NY, United States; 3Medicine, Yale University School of Medicine, New Haven, CT, United States POSTERS MONDAY JUNE 9TH

M413 EFFECTS OF LONG-TERM CREATINE SUPPLEMENTATION AND PHYSICAL EXERCISE ON BODY COMPOSITION, BONE MINERAL DENSITY AND RENAL FUNCTION IN RATS Larissa Gorayb Ferreira,1 Cassia Toledo Bergamaschi,2 Marize Lazaretti-Castro,3 Elizabete Ribeiro Barros,3 Ita Pfeferman Heilberg.1 1Nephrology Division, Universidade Federal de Sao Paulo, SP, Brazil; 2Physiology Division, Universidade Federal de Sao Paulo, SP, Brazil; 3Endocrinology Division, Universidade Federal de Sao Paulo, SP, Brazil

M414 AGES IN FOODS - DO THEY PLAY A ROLE IN PATIENTS WITH RENAL FAILURE? Vedat Schwenger,1 Kathrin Schoenfelder,2 Kai Waigel,2 Reinhold Deppisch,3 Martin Zeier,1 Thomas Henle,2 Eberhardt Ritz.1 MONDAY 1Dep. Internal Medicine, Nephrology, University of Heidelberg, Heidelberg, Germany; 2Institute of Food Chemistry, Technical University of Dresden, Dresden, Germany; 3Gambro Corporation Research, Hechingen, Germany

M415 PROTEIN INTAKE MORE THAN 0.5g/kgBW/day IS NOT EFFECTIVE TO SLOW THE PROGRESSION OF CHRONIC RENAL FAILURE Terukuni Ideura, Miyuki Shimazui, Kumiko Higuchi, Hironori Tayama, Ashio Yoshimura. Department of Internal Medicine, Showa University Fujigaoka Hospital, Yokohama, Kanagawa, Japan

M416 RANDOMIZED DOUBLE BLIND PLACEBO CONTROLLED TRIAL OF KETOANALOGUES IN RETARDATION OF CHRONIC RENAL FAILURE IN TROPICS Sunil Prakash,1 Dwarika Pande,1 K. Suresh,1 Hrishikesh Kulkarni.2 1Division of Nephrology, Northern Railway Central Hospital, New Delhi, Delhi, India; 2Department of Medicine, Surya Hospital, Pune, Maharashtra, India

M417 NUTRITION AND SKELETAL MUSCLE ASSESSMENT IN CHRONIC RENAL FAILURE PATIENTS ON DIETARY TREATMENT Adamasco Cupisti,1 Rosaria Licitra,2 Carmelo Chisari,2 Giovanni Manca Rizza,1 Claudia D’Alessandro,1 Fabio Galetta,1 Bruno Rossi,2 Giuliano Barsotti.1 1Internal Medicine, Nephrology Unit, University of Pisa, Pisa, Italy; 2Neurosciences, Rehabilitation Unit, University of Pisa, Pisa, Italy

M418 ANALYSIS OF THE FACTORS AFFECTING THE COURSE OF RENAL DISEASE PROGRESSION -IS THERE “POINT OF NO RETURN? Yuji Sato, Shouichi Fujimoto, Kazuhiro Yamada, Seiichiro Hara, Tanenao Eto. First Department of Internal Medicine, Miyazaki Medical College, Kiyotake, Miyazaki, Japan

M419 A FALL IN URINE PROTEIN WITH COMBINED ANGIOTENSIN CONVERTING ENZYME INHIBITOR (ACEI) AND AII RECEPTOR ANTAGONIST (AIIRA) TREATMENT PREDICTS A GOOD OUTCOME AT THREE YEARS IN PATIENTS WITH CHRONIC RENAL DISEASE WITH CONTINUING REDUCTION IN URINE PROTEIN LEV Priscilla Kincaid-Smith,1 Kenneth Fairley.2 1Department of Nephrology, Epworth Hospital, Richmond, Victoria, Australia; 2Epworth Hospital, Richmond, Victoria, Australia TH MONDAY JUNE 9 POSTERS

M420 ASSOCIATION OF ATHEROSCLEROTIC CORONARY ARTERY DISEASE (CAD) AND PULSE PRESSURE (PP) WITH RENAL DISEASE PROGRESSION Soonkil Kwon, Soon Bae Kim, Sang Koo Lee, Jung Sik Park. Internal Medicine, University of Ulsan, Seoul, Korea

M421 LIMITED VALUE OF RECIPROCAL CREATININE PLOTS IN PLANNING START OF DIALYSIS David Warland, Coralie Bingham, Martin Beaman, Anthony Nicholls. Renal Unit, Royal Devon and Exeter Hospital, Exeter, Devon, United Kingdom

M422 EARLY ARTERIOVENOUS FISTULA CONSTRUCTION DELAY DETEORIATION OF RENAL FUNCTION Marko Malovrh. Department of Nephrology, University Medical Center, Ljubljana, Slovenia

M423 TREATMENT WITH AN EXTREMELY HIGH DOSE OF AN AT1 RECEPTOR BLOCKER (ARB) PROMOTES SUPERIOR RENAL PROTECTION IN THE REMNANT KIDNEY MODEL (NX) Clarice K. Fujihara, Mariliza Velho, Glaucia R. Antunes, Luciana F. Carvalho, Denise M.A.C. Malheiros, Roberto Zatz. Renal Div, Dep Clin Med, Univ Sao Paulo, Sao Paulo, Brazil

M424 EFFICACY OF V1AANTAGONISM IN THE TREATMENT OF CHRONIC RENAL FAILURE Richard P.E. van Dokkum,1 Robert H. Henning,1 Gerjan Navis,1,2 Alex C.A. Kluppel,1 Dick de Zeeuw.1 1Clinical Pharmacology, University of Groningen, Groningen, Netherlands; 2Nephrology, Academic Hospital Groningen, Groningen, Netherlands

M425 AN ORAL SORBENT REDUCES OVERLOAD OF INDOXYL SULFATE AND PLASMA LEVEL OF TGF-b1 IN PATIENTS WITH CHRONIC RENAL FAILURE (CRF) Keisuke Kohno, Kiyoshi Tamaki, Junko Yoshimura, Seiji Ueda, Michiaki Usui, Hiroshi Miyazaki, Hidemi Nishida, Seiya Okuda. Department of Nephrology, Kurume University School of Medicine, Kurume, Fukuoka, Japan

M426 ANTIPROTEINURIC EFFECT OF RENIN-ANGIOTENSIN SYSTEM BLOCKADE IN PATIENTS WITH SYSTOLIC BLOOD PRESSURE LOWER THAN 115 mmHg Eduardo Gutierrez, Esther Gonzalez, Enrique Morales, Juan Carlos Herrero, Manuel Praga. Nephrology, Hospital 12 de Octubre, Madrid, Spain

M427 THE EFFECT OF TREATMENT WITH ULTRA HIGH DOSE CANDESARTAN (64MG) ON PROTEINURIA: INTERIM RESULTS OF A DOUBLE-BLIND, RANDOMIZED, MULTI-CENTER STUDY Erwin H. Fleischmann, Arnfried U. Klingbeil, Markus P. Schneider, Christian Delles, Roland E. Schmieder. Department of Medicine IV/4, University Erlangen-Nuremberg, Erlangen, Germany

M428 ANGIOTENSIN II RECEPTOR BLOCKER (ARB) LOWERS PLASMA LEVELS OF TGF-b1 IN PATIENTS WITH CHRONIC RENAL FAILURE (CRF) Junko Yoshimura, Kiyoshi Tamaki, Seiji Ueda, Michiaki Usui, Keisuke Kohno, Seiya Okuda. Department of Nephrology, Kurume Univeristy School of Medicine, Kurume, Fukuoka, Japan POSTERS MONDAY JUNE 9TH

M429 NEPHROPROTECTIVE AND ANTIFIBROGENIC EFFECTS OF ANGIOTENSIN RECEPTOR BLOCKER VALSARTAN IN CHRONIC GLOMERULONEPHRITIS PATIENTS Oksana Plieva, Mikhail Shvetsov, Lidia Kozlovskaya, Alexander Mischenko, Anna Scherbak. Department of Nephrology, Moscow Sechenov Medical Academy, Moscow, Russian Federation

M430 IS SMALL-DOSE COMBINATION OF ANGIOTENSIN RECEPTOR BLOCKER AND ANGIOTENSIN-CONVERTING ENZYME INHIBITOR STILL BENEFICIAL IN MANAGEMENT OF CRF?: A SIX-BY-FIVE FACTORIAL DESIGN PROSPECTIVE STUDY Naoyuki Nakao,1,2 Usami Takeshi,1 Atsuhiro Yoshida,1 Masayuki Tadaka,2 Genjiro Kimura.1 1Internal Medicine and Pathophysiology, Nagoya City University MONDAY Graduate School of Medicine, Nagoya, Aichi, Japan; 2Div. Nephrology, Gen Gen-Do Kimitsu Hospital, Kimitsu, Chiba, Japan TH MONDAY JUNE 9 POSTERS VITAMIN D AND PTH

M431 AG1478 SPECIFICALLY INHIBITS EPIDERMAL GROWTH FACTOR RECEPTOR PREVENTING PARATHYROID GLAND GROWTH INDUCED BY HIGH PHOSPHORUS IN UREMIC RATS Mario Cozzolino,1,2 Diego Brancaccio,2 Maurizio Gallieni,2 Eduardo Slatopolsky,1 Adriana Dusso.1 1Renal Division, Washington University, St. Louis, MO, United States; 2Renal Unit, Ospedale San Paolo, Milan, Italy

M432 EFFECTS OF VITAMIN D ANALOGUES ON RENAL AND INTESTINAL Ca2+ TRANSPORT PROTEINS IN 25- HYDROXYVITAMIN D3-1a-HYDROXYLASE KNOCKOUT MICE Joost G.J. Hoenderop,1 Annemiete W.C.M. van der Kemp,1 Stephen A. Strugnell,2 Colleen M. Urben,2 Rene J.M. Bindels.1 1Department of Cell Physiology, University Medical Center Nijmegen, Netherlands; 2Bone Care International, Middleton, WI, United States

M433 DIMINISHED EXPRESSION OF Sp1, THE NUCLEAR TRANSCRIPTIONAL FACTOR, LINKS WITH THE DOWN- REGULATION OF p21, p27 AND CALCIUM SENSING RECEPTOR (CaSR) EXPRESSION IN HYPERPLASTIC PARATHYROID GLANDS DUE TO UREMIA Masanori Tokumoto, Masatomo Taniguchi, Dai Matsuo, Kazuhiko Tsuruya, Kyoichi Fukuda, Hidetoshi Kanai, Hideki Hirakata, Mitsuo Iida. Department of Medicine & Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

M434 MOLECULAR MECHANISM OF THE VITAMIN D (VD)- INDUCED REGRESSION OF PARATHYROID GLAND (PTG) HYPERPLASIA IN UREMIC RATS FED HIGH PHOSPHORUS DIET: RESTORATION OF THE EXPRESSIONS OF VD RECEPTOR (VDR), CALCIUM SENSING RECEPTOR (CaR) AND p21 Masatomo Taniguchi, Masanori Tokumoto, Dai Matsuo, Hideki Yotsu-eda, Kosuke Masutani, Kazuhiko Tsuruya, Kyoichi Fukuda, Hidetoshi Kanai, Hideki Hirakata, Mitsuo Iida. Dept of Med & Clin Sci, Graduate School of Med Sci, Kyushu University, Fukuoka, Japan

M435 EXPRESSION OF PCNA AND VITAMIN D RECEPTOR IN THE PARATHYROID WITH SECONDARY HYPERPARATHYROIDISM Sun Bin, Wang Xiaoyun, Zhou Fuhua, Yu Xianbao, Hu Jianmin. Department of Nephrology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

M436 HYPERPHOSPHATAEMIA INCREASES THE RISK OF CHROMOSOMAL ABERRATIONS IN PARATHYROID NODULES OF URAEMIC PATIENTS Jerzy Chudek,1,2 Anett Nagy,1 Gyula Kovacs,1 Eberhard Ritz,3 Franciszek Kokot.2 1Lab for Molecular Oncology, Ruprecht-Karls Univ, Heidelberg, Germany; 2Dept. of Nephrology, Endocrinology and Metabolic Diseases, Silesian Univ Medical School, Katowice, Poland; 3Dep. of Internal Medicine, Ruprecht-Karls Univ, Heidelberg, Germany

M437 ROLE OF PHOSPHORUS IN THE PATHOGENESIS OF SECONDARY HYPERPARATHYROIDISM Wang Xiaoyun,1 Wang Xiaobing,1 Zhou Fouhua,1 Liu Biao,2 Peng Tao.3 1Renal Division, Jiangsu Province Hospital, Nanjing, Jiangsu, China; 2Nuclear Medicine Division, Jiangsu Province Hospital, Nanjing, Jiangsu, China; 3Pathology Division, Nangjing Medical University, Nanjing, Jiangsu, China POSTERS MONDAY JUNE 9TH

M438 THE RELATIVE SECRETORY CAPACITY OF THE PARATHYROIDS IS DIMINISHED IN UREMIC RATS AND NORMALIZED AFTER EXPERIMENTAL KIDNEY TRANSPLANTATION Ewa Lewin,1 Helle G. Carstensen,2 Klaus Olgaard.2 1Nephrological Dept. B, Herlev Hospital, University of Copenhagen, Herlev, Denmark; 2Nephrological Dept. P, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

M439 RELATIONSHIP BETWEEN VITAMIN D RECEPTOR GENE POLYMORPHISM AND SECONDARY HYPERPATHYROIDISM IN CHINESE HAN PATENTS WITH CHRONIC RENAL FAILURE Weihong Zhao, Xiaoyun Wang. Department of Nephrology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China MONDAY

M440 PARATHYROID FUNCTION AND VITAMIN-D RECEPTOR POLYMORPHISMS IN HEMODYALISED UREMIC PATIENTS Balazs Györffy,1 Zsuzsa Süveges,1 Tivadar Tulassay,1 Andras Szabo,1 Barna Vasarhelyi.2 11st Dept of Paediatrics, Semmelweis University, Budapest, Hungary; 2Research Laboratory for Paediatrics and Nephrology, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary

M441 SCANTIBODIES PTH TEST FOR A MORE ACCURATE EVALUATION OF PARATHYROID FUNCTION IN CHRONIC DIALYSIS PATIENTS Tiziano Lusenti,1 Vincenzo Franco,1 Fausto Soliani,1 Roberto Rustichelli,1 Pierpaolo Borgatti,1 Simonetta Cavalieri,2 Claudio Dotti.2 1II Medicine, O.U. Nephrology and Dialysis, Reggio Emilia, Italy; 2Clinical Pathology, Endocrinology Laboratory, Reggio Emilia, Italy

M442 THE ASSESSMENT OF A CIRCULATING HYPOCALCEMIC PARATHYROID HORMON (PTH) FRAGMENT IN ADDITION TO 1-84 PTH IN PATIENTS WITH HYPERPARATHYROIDISM BEFORE AND AFTER PARATHYROIDECTOMY Ping Gao,1 Tom Cantor,1 Pierre D’Amour,2 Hiroyuki Yamashita.3 1Research and Development, Scantibodies Laboratory, Inc., Santee, CA, United States; 2Centre de Recherche du CHUM, University of Montreal, Montreal, QC, Canada; 3Endocrinology, Noguchi Thyroid Clinic, Beppu, Oita, Japan

M443 CAN A CONVENTIONAL INTACT PARATHYROID HORMONE ASSAY ESTIMATE AUTHENTIC PLASMA 1-84 PARATHYROID HORMONE LEVELS? Junichiro Kazama, Kentaro Omori, Hiroki Maruyama, Ichiei Narita, Fumitake Gejyo. Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan

M444 THE CHANGE OF 1-84 PTH/7-84 PTH FRAGMENT RATIO IN HEMODIALYSIS PATIENTS UNDER VITAMIN D I.V. THERAPY Takashi Kihara,1 Haruo Ichikawa,1 Hiroko Kohmoto,1 Ai Yano,1 Sigeru Akagi,1 Kazushi Nakao,1 Isao Kumagai,2 Yoshio Nagake,3 Hirofumi Makino.1 1Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan; 2Department of Internal Medicine, Teraoka Memorial Hospital, Hiroshima, Japan; 3Department of Nephrology, Okayama Saiseikai General Hospital, Okayama, Japan TH MONDAY JUNE 9 POSTERS

M445 STUDY OF OSTEOCALCIN AND SERUM b-CROSSLAPS ON 46 PATIENTS ON REGULAR HEMODIALYSIS WITH SECONDARY HYPERPARATHYROIDISM (SHPTH) Guillermo Rojas, Maria-Cristina Alvarez, Carlos Cacciuttolo, Hernan Aguirre. Departamento de Investigacion y Desarrollo, Centrodialisis Ltda., Vina del Mar, Region de Valparaiso, Chile

M446 RELATIONSHIP BETWEEN SIZE ESTIMATED BY ULTRASONOGRAPHY AND HYPERPLASTIC PATTERN OF PARATHYROID GLANDS IN PATIENT WITH RENAL HYPERPARATHYROIDISM Susumu Matsuoka,1 Yoshihiro Tominaga,1 Tuneo Ueki,1 Norihiko Gotou,1 Akio Katayama,1 Toshihito Haba,1 Kazuharu Uchida,1 Akimasa Nakao.2 1Surgery, Renal Center, Nagoya Daini Red Cross Hospital, Nagoya, Aichi Prefecture, Japan; 2Surgery II, Nagoya University, Nagoya, Aichi Prefecture, Japan

M447 RELATIONSHIP BETWEEN PARATHYROID GLAND ACTIVITY AND PARATHYROID GLAND VOLUME Ljiljana Komadina, Zorica Rasic, Steva Pljesa, Gordana Perunicic- Pekovic, Rodoljub Markovic, Vesna Djurkovic, Ljiljana Suric-Lambic. Department of Nephrology, University Hospital Zemun, Beograd, Serbia, Yugoslavia

M448 PARATHYROID GLANDS ENLARGEMENT IN HD PATIENTS WITHOUT VITAMIN D TREATMENT MORE THAN 5 YEARS Ginova Nainggolan, Maruhum Bonar Marbun, Parlindungan Siregar, Suhardjono , J. Pudji Rahardjo, Wiguno Prodjosudjadi. Division of Nephrology and Hypertension Dept. of Internal Medicine, Faculty of Medicine University of Indonesia, Jakarta, DKI Jakarta, Indonesia

M449 HYPOPARATHYROIDISM IN HEMODIALYSIS PATIENTS Drasko Pavlovic,1 Lidija Orlic,2 Goran Samardjija,3 Branko Heinrich,4 Marko Jakic,3 Branka Sladoje-Martinovic.2 1Dept. of Nephrology and Dialysis, Sveti Duh General Hospital, Zagreb, Croatia; 2Dept. of Nephrology and Dialysis, University Hospital Rijeka, Rijeka, Croatia; 3Dept. of Dialysis, University Hospital Osijek, Osijek, Croatia; 4Dept. of Dialysis, General Hospital Koprivnica, Koprivnica, Croatia

M450 IMPACT OF GEOGRAPHY AND ECONOMIC STATUS ON THE PREVALENCE OF SECONDARY HYPERPARATHYROIDISM IN HEMODIALYSIS PATIENTS Francis Dumler,1 Luis Concepcion.2 1Division of Nephrology, William Beaumont Hospital, Royal Oak, MI, United States; 2Division of Nephrology, Scott & White Clinic, Temple, TX, United States

M451 ABNORMALITIES OF CALCIUM, PHOSPHATE, VITAMIN D AND PARATHYROID HORMONE IN EARLY CHRONIC KIDNEY DISEASE: RESULTS FROM THE CHRONIC RENAL IMPAIRMENT IN BIRMINGHAM (CRIB) STUDY Daniel Zehnder,1 Martin Landray,2 David Wheeler,3 William Fraser,5 Sarah Nuttall,4 John Townend,4 Simon Ball,1 Martin Hewison.4 1Department of Nephrology, University of Birmingham, Birmingham, United Kingdom; 2Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom; 3Centre for Nephrology, University College, London, United Kingdom; 4Division of Medicine, Queen Elizabeth Hospital, Birmingham, United Kingdom; 5Department of Clinical Chemistry, University of Liverpool, Liverpool, United Kingdom POSTERS MONDAY JUNE 9TH

M452 INFLUENCE OF PREDIALYTIC INTACT-PTH ONTO SECONDARY HYPERPARATHYROIDISM IN PATIENTS WITH CHRONIC MAINTENANCE HAEMODIALYSIS Satoshi Etoh, Toshiaki Murata, Ritsuya Noda, Satoru Ogahara, Hidetoshi Kaneoka, Takao Saito. Division of Nephrology and Rheumatology, Department of Internal Medicine, Fukuoka University School of Medicine, Fukuoka, Japan

M453 1-84 PARATHYROID HORMONE (1-84 PTH) AND INSULIN-LIKE GROWTH FACTOR I (IGF-1) IN RENAL OSTEODYSTROPHY F. Carluccio,1 G.B. Piccoli,2 A. Tasco,1 R. Craca,1 G. Stefanelli,1 W. Siems.3 1Nephrology O.U., Hospital, Scorrano, Lecce, Italy; 2Chair of Nephrology, Univesity, Torino, Italy; 3Herzog Jiulius Hospital, Bad- Harzburg, Germany MONDAY M454 MILD HYPERPARATHYROIDISM IS ASSOCIATED WITH IMPROVED SURVIVAL IN HEMODIALYSIS PATIENTS Marco Ianche, Mary Artero, Francesco Bianco, Guido Enzmann, Giovanni Galli, Massimo Grignetti, Massimiliano Martone, Silvana Savoldi, Sergio Vianello, Eliana Vidi, Giovanni Panzetta. Division of Nephrology and Dialysis, Ospedali Riuniti di Trieste, Trieste, Italy

M455 ORAL AND INTRAVENOUS APPLICATION OF ALFACALCIDOL IN THE THERAPY OF RENAL HYPERPARATHYROIDISM Heinz Juergen Deuber. KfH, Dialysis Center, Erlangen, Germany

M456 INFLUENCE OF CHOLECALCIFEROL ON SELECTED CYTOKINES IN HAEMODIALYSIS PATIENTS Dörte Bondick,1 Hans-Peter Bosselmann,1 Dirk Reinhold,2 Heinrich Schmidt-Gayk,3 Klaus Hinrich Neumann.1 1Division of Nephrology, Otto-von-Guericke-University, Magdeburg, Germany; 2Institute of Immunology, Otto-von-Guericke- University, Magdeburg, Germany; 3Laboratory Group, Heidelberg, Germany

M457 IS THE VOLUME OF THE PARATHYROID GLAND A PREDICTOR OF THE MAXACALCITOL RESPONSE IN ADVANCED RENAL HYPERPARATHYROIDISM? Yoshihiro Tominaga,1 Kazutaka Kukita,2 Satoshi kurihara,3 Takatoshi Kakuta,4 Daijo Inakuma,5 Shuichi Tsutsui,6 Yoshinari Tsuruta,7 Yoshiki Nishizawa,8 Kazumichi Ota,9 Morimasa Kuwahara.10 1Dept. of Surgery, Renal Center, Nagoya 2nd Red Cross Hosp., Nagoya, Aichi, Japan; 2Surgery, Sapporo Hokuyu Hosp., Sapporo, Hokkaido, Japan; 3Nephrology, Kasukabe-Shuwa Hosp., Kasukabe, Saitama, Japan; 4Nephrology, School of Medicine, Tokai Univ., Isehara, Kanagawa, Japan; 5Nephrology, Tosei General Hosp., Seto, Aichi, Japan; 6Nephrology, Aoi Central Hosp., Okazaki, Aichi, Japan; 7Nephrology, Meiyo Clinic, Toyohashi, Aichi, Japan; 8Nephrology, Osaka City Univ. Graduate School of Medicine, Osaka, Japan; 9Nephrology, Takasu Hosp., Takasu, Kochi, Japan; 10Urology, Fujisaki Hosp., Karatsu, Saga, Japan

M458 COMPARISON OF EFFICACY BETWEEN ORAL AND INTRAVENOUS 22-OXACALCITRIOL THERAPIES IN CHRONIC HEMODIALYSIS PATIENTS Shigeo Tamura,2 Kazue Ueki,1 Takashi Kuroiwa,1 Yoriaki Kaneko,1 Keijyu Hiromura,1 Akiyasu Tsuchida,2 Hironobu Kawai,3 Ryoji Wakamatsu,4 Yoshihisa Nojima.1 1Third Dept. of Internal Medicine, Gunma University, Maebashi, Gunma, Japan; 2Internal Medicine, Toho Hospital, Nitta, Gunma, Japan; 3Internal Medicine, Saiseikai Maebashi Hospital, Maebashi, Gunma, Japan; 4Interanal Medicine, Nishikatakai Clinic, Maebashi, Gunma, Japan TH MONDAY JUNE 9 POSTERS

M459 RELATIONSHIP BETWEEN PARATHYROID GLAND SIZE AND RESPONSIVENESS TO MAXACALCITOL THERAPY IN PATIENTS WITH SECONDARY HYPERPARATHYROIDISM Eiji Ishimura,1 Senji Okuno,3 Kayoko Kitatani,3 Hidenori Chou,3 Akihiko Ban,3 Kyoko Nagasue,3 Yasuro Kumeda,3 Tomoyuki Yamakawa,3 Masao Kim,3 Yasuo Imanishi,1 Tetsuo Shoji,2 Masaaki Inaba,2 Yoshiki Nishizawa.2 1Nephrology, Osaka City Univ. Graduate School of Medicine, Osaka, Japan; 2Metabolism, Endocrinology, and Molecular Medicine, Osaka City Univ. Graduate School of Medicine, Osaka, Japan; 3Shirasagi Hosp., Osaka, Japan

M460 LONG-LASTING PTH SUPPRESSION FOLLOWING DOXERCALCIFEROL (1aD²) THERAPY: ROLE OF THE DURATION OF TREATMENT Jack W. Coburn,1,2 Hla M. Maung,1,2 the Doxercalciferol Study Group.1,2 1Nephrology Section, West Los Angeles V.A. Healthcare Center & UCLA School of Medicine, Los Angeles, CA, United States; 2Bone Care International, Middleton, WI, United States

M461 CONTROL OF SECONDARY HYPERPARATHYROIDISM (HPTH) WITH CALCITRIOL (D3) OR 1-ALFACALCIDOL (1aD) IN PATIENTS WITH EARLY CHRONIC RENAL FAILURE (CRF) Arturo Wadgymar, Olga Jabbaz, Roza Berkowitz, Gordon Wong, George Wu. Medicine, Credit Valley Hospital, Mississauga, ON, Canada

M462 THE USEFULNESS OF THE COMBINATION THERAPY WITH INTRAVENOUS MAXACALCITOL THERAPY AND PERCUTANEOUS ETHANOL INJECTION THERAPY (PEIT) IN SECONDARY HYPERPARATHYROIDISM Motoko Tanaka,1 Kazuko Itoh,1 Kazunori Matsushita,1 Kazutaka Matsushita,1 Kenichiro Kitamura,2 Hiroshi Nonoguchi,2 Kimio Tomita.2 1Dept. of Nephrology, Akebono Clinic, Kumamoto, Japan; 2Third Dept. of Internal Medicine, Kumamoto Univ. School of Medicine, Kumamoto, Japan

M463 UVB IRRADIATION IS SUPERIOR TO VITAMIN D SUPPLEMENTATION DUE TO EXTRARENAL SYNTHESIS OF CALCITRIOL Rolfdieter Krause,1,2 Brigitte Matulla-Nolte,1 Jeanette Dobberke,1 Heinrich Schmidt-Gayk,3 John Flanagan,4 Tai Chen,4 Michael Holick,4 Malte Buehring.1 1Dept. Natural Medicine, Benjamin Franklin Medical Ctr., Free Univ., Berlin, Germany; 2Moabit Dialysis Center, Kuratorium Dialyse & Nierentransplantation (KfH), Berlin, Germany; 3Lab. Group, Endocrine Unit, Heidelberg, Germany; 4Vitamin D, Skin, and Bone Research Lab., Boston Univ. Medical Center, Boston, MA, United States

M464 PARATHYROIDECTOMY AFTER RENAL GRAFT TRANSPLANTATION Petr Bubenicek,1 Ivo Sotornik,1 Milos Adamec,2 Vladimir Teplan,1 Stefan Vitko.3 1Dept. of Nephrology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic; 2Dept. of Transplant Surgery, Institute for Clinical and Experimental Medicine, Prague, Czech Republic; 3Transplantcentre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

M465 PERCUTANEOUS ETHANOL INJECTION TREATMENT (PEIT) IN POST-RENAL TRANSPLANT PATIENTS WITH PERSISTENT HYPERPARATHYROIDISM Walter Douthat,1 Santiago Orozco,2 Javier de Arteaga,1 Pablo Massari.1 1Bone and Mineral Unit, 2Image Diagnosis, Hospital Privado-Centro Medico de Cordoba, Cordoba, Argentina POSTERS MONDAY JUNE 9TH

M466 EFFECTS OF NATIVE VITAMIN D SUPPLEMENTATION IN PATIENTS ON MAINTENANCE HEMODIALYSIS Adrienn Marton,1 Csaba Ambrus,2 Csilla Almasi,1 Klara Berta,1,2 Erzsebet Csaktornyai,2 Zsuzsa Vezekenyi,2 Gyorgy Deak,1,2 Csaba Horvath,1 Peter Lakatos,1 Andras Szabo,3 Istvan Mucsi.1,2,4 11st Dept. of Internal Medicine, Semmelweis University, Budapest, Hungary; 2SE-FMC Dialysis Center, Semmelweis University, Budapest, Hungary; 31st Dept. of Pediatrics, Semmelweis University, Budapest, Hungary; 4Institute of Behavioral Sciences, Semmelweis

M467 PARATHYROIDECTOMY LOWERS ELEVATED NEUTROPHIL CYTOSOLIC CALCIUM CONCENTRATION OF DIALYSIS PATIENTS WITH SEVERE HYPERPARATHYROIDISM Robert Deicher,1 Bernhard Kirsch,1 Bruno Niederle,2 Walter Hörl.1 1Department of Medicine, Division of Nephrology and Dialysis, MONDAY University of Vienna, Vienna, Austria; 2Department of Surgery

M468 PARATHYROIDECTOMY IN RENAL TRANSPLANT PATIENTS. ONE YEAR FOLLOW-UP STUDY Aluizio Carvalho,1 Fellype Barreto,1 José Pestana,1 Rodrigo Santos,2 Simone Lima,1 Alessandra Barbosa,1 Rosélia Lobão.1 1Nephrology Division, Escola Paulista de Medicina - UNIFESP, São Paulo, Brazil; 2Head and Neck Surgery Division, Escola Paulista de Medicina - UNIFESP, São Paulo, Brazil

M469 IMPROVEMENT OF SECONDARY HYPERPARATHYROIDISM BY IBANDRONATE Heinz Juergen Deuber. KfH, Dialysis Center, Erlangen, Germany

M470 TOTAL PARATHYROIDECTOMY WITHOUT AUTOTRANSPLANTATION IS SAFE AND POSSIBLY BENEFICIAL IN HEMODIALYSIS PATIENTS Joachim Groll,1 Gerd Schwietzer,1 Georg Arlt.2 1Department of Nephrology, Nephrologisches Zentrum Berlin- Weissensee, Berlin, Germany; 2Department of Surgery, Parkklinik Weissensee, Berlin, Germany

M471 INTRAOPERATIVE MONITORING OF QUICK INTACT PTH (QPTH) AS A PREDICTIVE TOOL OF SUCCESSFUL PARATHYROIDECTOMY (PTX) IN PATIENTS WITH RENAL HYPERPARATHYROIDISM Sandro Bandini,1 Maria Luisa Tommasi,2 Paolo Cicchi,3 Franco Bergesio,1 Paolo Conti,1 Cinzia Cerretini,1 Giovanni Mancini,1 Luciano Moscarelli,1 Marco Gallo,1 Alberto Brocchi,2 Silvia Raspanti,2 Maria Zanazzi,1 Maurizio Salvadori.1 1Nephrology and Dialysis Unit, Careggi University Hospital, Florence, Italy; 2Physiopathology, University of Florence, Florence, Italy; 3General Surgery, Careggi University Hospital, Florence, Italy

M472 IMPROVED HOSPITALIZATION OUTCOMES IN HEMODIALYSIS PATIENTS TREATED WITH PARICALCITOL Joel Melnick,1 Michael Amdahl,1 Angelo Mathes,1 Carla Koch,1 Laura Williams,1 Jin Tian,1 Deborah Dobrez,2 Stuart Sprague.3 1GPRD, Abbott Laboratories, Abbott Park, IL, United States; 2Outcomes Research and Education, Northwestern University, Chicago, IL, United States; 3Medicine, Northwestern University, Evanston, IL, United States

M473 INFLUENCE OF 1.5MMOL/L CALCIUM DIALYSATE ON SERUM TOTAL CALCIUM, INTACT PARATHYROID HORMONE, AND BLOOD PRESSURE Li Zuo, Mei Wang, Hui Du, Li Yang. Renal Division, Department of Medicine, First Hospital, Peking University, Beijing, China TH MONDAY JUNE 9 POSTERS

M474 AGGRESSIVE CALCIUM REPLACEMENT REGIMEN IN PREVENTING POST PARATHYROIDECTOMY HUNGRY BONE SYNDROME IN PATIENTS WITH SEVERE TERTIARY HYPERPARATHYROIDISM Hin-Seng Wong, Zaki Morad. Dept of Nephrology, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia

M475 EFFECT OF NPS R-467 ON INTRACELLULAR FREE CALCIUM IN CULTURED PARATHYROID CELLS FROM SEVERE SECONDARY HYPERPARATHYROIDISM PATIENT Xiaoyun Wang,1 Ningning Wang,1 Cuiping Liu,2 Hongfei Wu.3 1Dept. of Nephrology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China; 2Dept. of Endocrinology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China; 3Dept. of Urinology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

M476 THE IMPACT OF HEPATIC IMPAIRMENT ON THE PHARMACOKINETICS OF CINACALCET HCl R. Harris, D. Padhi, M. Salfi, W. Yates, L. Henday, J. Hansen, J. Sullivan. Pharmacokinetics and Drug Metabolism/Clinical Pharmacology, Amgen Inc., Thousand Oaks, CA, United States

M477 THE PHARMACOKINETICS OF CINACALCET HCl ARE NOT ALTERED BY RENAL IMPAIRMENT OR MODE OF RENAL REPLACEMENT THERAPY D. Padhi, R. Harris, M. Salfi, W. Yates, L. Henday, J. Hansen, J. Sullivan. Clinical Pharmacology, Amgen Inc., Thousand Oaks, CA, USA

M478 CINACALCET HCL EFFECTIVELY CONTROLS BOTH PARATHYROID HORMONE (PTH) AND CALCIUM x PHOSPHORUS PRODUCT (Ca x P) IN PATIENTS WITH SECONDARY HYPERPARATHYROIDISM (SHPT) T. Drueke,1 J. Cunningham,2 N. Baker,3 S.A. Turner,3 W.G. Goodman.4 1Dept. de Nephrologie, Groupe Hospitalier Necker, Paris, France; 2Dept. of Renal Medicine, Royal London Hospital, London, UK; 3Dept. of Clinical Development, Amgen Inc., Thousand Oaks, CA, USA; 4Dept. of Nephrology, UCLA School of Medicine, Los Angeles, CA, USA

M479 SUSTAINED, LONG-TERM REDUCTIONS IN PARATHYROID HORMONE (iPTH) AFTER 3 YEARS OF TREATMENT WITH THE CALCIMIMETIC CINACALCET HCL IN PATIENTS WITH SECONDARY HYPERPARATHYROIDISM (SHPT) J. Cunningham,1 H. Holzer,2 H. Reichel,3 J. Braun,4 C. Hawley,5 P. Urena,6 V. Zani,7 N. Baker,7 L. McCary,7 T. Drueke.8 1Dept. of Renal Medicine, Royal London Hospital, United Kingdom; 2Medizinische Universitaetsklinik Graz, Austria; 3Nephrological Center, Schwenningen, Germany; 4KfH Kuratorium für Dialyse, Nürnberg, Germany; 5Princess Alexandra Hospital, Woolloongabba, Australia; 6Clinique de l’Orangerie, Aubervilliers, France; 7Dept. of Clinical Research Management, Amgen Inc., United States; 8Hospital Neckler, Paris, France

M480 SUSTAINED CONTROL OF URAEMIC SECONDARY HYPERPARATHYROIDISM AFTER THREE YEARS OF TREATMENT WITH THE CALCIMIMETIC CINACALCET HCL: A SINGLE CENTRE EXPERIENCE P. Ureña,1 N. Legoupil,2 M.C. de Vernejoul,2 C. Guédon-Rapoud,1 N. Baker,3 S.A. Turner,3 T. Drueke.4 1Service de Nephrologie, Clinique de l’Orangerie, Aubervilliers, France; 2Departement de Medicine, Hôpital Lariboisière, Paris, France; 3Dept. of Clinical Development, Amgen Inc., Thousand Oaks, CA, United States; 4Departement de Nephrologie, Groupe Hospitalier Necker, Paris, France POSTERS MONDAY JUNE 9TH

ERYTHROPOIETIN

M481 EFFECTS OF ERYTHROPOIETIN ON ENDOTHELIN-1 RELEASE AND ON MITOGEN-ACTIVATED PROTEIN KINASE ERK 1/2 VIA EPO RECEPTORS IN PORCINE AND IN HUMAN VASCULAR ENDOTHELIAL CELLS Herbert J. Kramer, Katharina Ehrenforth, Angela Bäcker, Dirk Bokemeyer. Renal Section, Medical Policlinic, University of Bonn, Bonn, Germany

M482 ERYTHROPOIETIN REGULATES ENDOTHELIAL PROGENITOR CELLS IN VITRO

Ferdinand Hermann Bahlmann, Kirsten de Groot, Jens-Michael MONDAY Spandau, Aimee Leigh Landry, Barbara Hertel, Torsten Duckert, Sascha Michael Boehm, Hermann Haller, Danilo Fliser. Div. Nephrol, Dep. Int. Med., Hannover Medical School, Hannover, Germany

M483 ERYTHROPOIETIN REGULATES ENDOTHELIAL PROGENITOR CELLS IN VIVO Kirsten de Groot, Ferdinand Hermann Bahlmann, Jens-Michael Spandau, Aimee Leigh Landry, Barbara Hertel, Torsten Duckert, Sascha Michael Boehm, Hermann Haller, Danilo Fliser. Div. Nephrol., Dept. Int. Med., Hannover Medical School, Hannover, Germany

M484 REGULATION OF ERYTHROCYTE APOPTOSIS BY ERYTHROPOIETIN Christina Birka, Svetlana Myssina, Philipp A. Lang, Karl S. Lang, Christophe Duranton, Stephan M. Huber, Thomas Wieder, Florian Lang. Dept. of Physiology, Eberhard-Karls-University of Tuebingen, Tuebingen, Germany

M485 EFFECT OF ERYTHROPOIETIN ADMINISTRATION ON RBC- ASSOCIATED PAF-ACETYLHYDROLASE ACTIVITY IN PATIENTS WITH CHRONIC RENAL FAILURE Eleni C. Papavasiliou,1 Chariklia Gouva,2 K.P. Katopodis,2 A.D. Tselepis,1 K.C. Siamopoulos.2 1Laboratory of Biochemistry, Department of Chemistry, University of Ioannina; 2Department of Nephrology, University Hospital of Ioannina, Ioannina, Greece

M486 LYMPHOCYTE PC-1 EXPRESSION IN PATIENTS ON MAINTENANCE HEMODIALYSIS TREATED WITH HUMAN RECOMBINANT ERYTHROPOIETIN AND 1-ALPHA-D3 Vladisav Stefanovic, Vidojko Djordjevic, Marina Avramovic, Zorica Dimitrijevic, Predrag Vlahovic. Institute of Nephrology and Hemodialysis, Faculty of Medicine, Nis, Serbia, Yugoslavia

M487 MYCOPHENOLIC ACID INHIBITS BASAL AND HYPOXIA- INDUCED ERYTHROPOIETIN PRODUCTION OF HepG2 CELLS IN VITRO Stefan Gauer, Nicholas Obermüller, Christiane Hansen, Binytha Wegener, Helmut Geiger, Ingeborg A. Hauser. Funktionsbereich Nephrologie, Klinikum der J.W.Goethe-Universität Frankfurt, Frankfurt am Main, Germany

M488 EFFECT OF ERYTHROPOIETIN ON POLYMORPHONUCLEAR LEUKOCYTE FUNCTIONS IN PREDIALYSIS PATIENTS Hemal Shah,1 Sangeeta Samadharman,2 Renuka Kudtarkar,1 Nirmala Rege,2 Alan Almeida.1 1Department of Nephrology, Seth GS Medical College and Kem Hospital, Mumbai, India; 2Department of Pharmacology, Seth GS Medical College and Kem Hospital, Mumbai, India TH MONDAY JUNE 9 POSTERS

M489 ERYTHROPOIETIN AND ERYTHROPOIETIN RECEPTOR EXPRESSION IN INJURED NERVOUS SYSTEM Giovanni Grasso,1 Alessandra Sfacteria,2 Alessio Sturiale,3 Gioacchino Calapai,4 Carmela Aloisi,3 Giuseppe Piedimonte,2 Francesco Tomasello,1 Michele Buemi.3 1Dept. of Neurology and Neurosurgery, Institute of Neurosurgery, Messina, Italy; 2Dept. of Veterinary Pathology, Messina, Italy; 3Dept. of Internal Medicine, Messina, Italy; 4Dept. of Pharmacology, Messina, Italy

M490 EFFECTS OF ERYTHROPOIETIN ON GONADOTROPHIC HORMONES AND SEXUAL FUNCTION IN HAEMODIALYSED PATIENTS H. Resic,1 V. Sahovic,1 A. Alajebegovic,2 E. Suljic,2 E. Mesic,3 E. Leto.1 1Center for Haemodialysis, Clinical Center Univ. of Sarajevo, Bosnia and Herzegowina; 2Neurology Clinic, Clinical Center Univ. of Sarajevo, Bosnia and Herzegowina; 3Clinic for Nephrology, Dialysis and Transplantation, Univ. of Tuzla, Bosnia

M491 RHUEPO AND IRON THERAPY MAY INCREASE SERUM IGF-1! Hidenori Matsuo. Dialysis Ctr., Hidaka Hosp., Takasaki, Japan

M492 LEFT VENTRICULAR HYPERTROPHY AND ASSOCIATED VARIABLES IN THE ‘CARDIOVASCULAR RISK REDUCTION BY EARLY ANAEMIA TREATMENT WITH EPOETIN BETA’ (CREATE) TRIAL Kai-Uwe Eckardt,1 Naomi Clyne,2 Tilman Drüeke,3 Francesco Locatelli,4 Iain Macdougall,5 Dimitrios Tsakiris.6 1Dept. of Nephrology and Medical Intensive Care, Humboldt Univ., Berlin, Germany; 2Dept. of Medicine, Södertälje Hospital, Södertälje, Sweden; 3INSERM Research Unit 507, Necker Hosp., Paris, France; 4Dept. of Nephrology and Dialysis, Osp.A Manzoni, Lecco, Italy; 5Dept. of Renal Medicine, King’s College Hosp, London, UK; 6Dept. of Nephrology, Veria General Hospital, Veria, Greece

M493 QUALITY OF LIFE ASSESSMENT IN THE ‘CARDIOVASCULAR RISK REDUCTION BY EARLY ANAEMIA TREATMENT WITH EPOETIN BETA’ (CREATE) STUDY Naomi Clyne,1 Tilman Drüeke,2 Kai-Uwe Eckardt,3 Francesco Locatelli,4 Iain Macdougall,5 Dimitrios Tsakiris.6 1Dept. of Medicine, Södertälje Hosp., Södertälje, Sweden; 2INSERM Research Unit 507, Necker Hosp., Paris, France; 3Dept. of Nephrology and Medical Intensive Care, Humboldt Univ,, Berlin, Germany; 4Dept. of Nephrology and Dialysis, Osp. A Manzoni, Lecco, Italy; 5Dept. of Renal Medicine, King’s College Hospital, London, UK; 6Dept of Nephrology, Veria General Hosp., Veria, Greece

M494 CARDIOVASCULAR DISEASE (CVD) CHARACTERISTICS OF CHRONIC KIDNEY DISEASE (CKD) PATIENTS ENROLLED IN THE ‘CARDIOVASCULAR RISK REDUCTION BY EARLY ANAEMIA TREATMENT WITH EPOETIN BETA’ (CREATE) STUDY Tilman Drüeke,1 Francesco Locatelli,2 Naomi Clyne,3 Kai-Uwe Eckardt,4 Iain Macdougall,5 Dimitrios Tsakiris.6 1INSERM Research Unit 507, Necker Hosp., Paris, France; 2Dept. of Nephrology and Dialysis, Osp. A Manzoni, Lecco, Italy; 3Dept. of Medicine, Södertälje Hospital, Södertälje, Sweden; 4Dept. of Nephrology and Medical Intensive Care, Humboldt Univ., Berlin, Germany; 5Dept. of Renal Medicine, King’s College Hosp., London, UK; 6Dept. of Nephrology, Veria General Hosp., Veria, Greece POSTERS MONDAY JUNE 9TH

M495 MAINTENANCE HEMATOCRIT LEVELS AND MORTALITY IN HEMODIALYSIS PATIENTS WITH ERYTHROPOIETIN TREATMENT Masashi Suzuki,1 Yoshihei Hirasawa,1 rHuEPO Survey Group Members.2 1Department of Internal Medicine, Shinrakuen Hospital, Niigata, Niigata Prefecture, Japan; 2rHuEPO Survey Group, Japan

M496 CARDIOVASCULAR EFFECTS OF THE PARTIAL OR COMPLETE CORRECTION OF ANEMIA WITH ERYTHROPOIETIN THERAPY IN PREDIALYSIS PATIENTS Luis Marcas,1 Alberto Martinez-Vea,1 Alfredo Bardaji,1 Cristina Gutierrez,1 Carmen Garcia,1 Teresa Compte,2 Carmen Peralta,1 Pedro Angelet,2 Jesus Angel Oliver.1 1Nephrology, Cardiology and Research Unit, Hosp. Univ. de Tarragona Joan XXIII, Tarragona, Spain; 2Renal Unit, Hosp. de la MONDAY Santa Creu, Tortosa, Tarragona, Spain

M497 EXERCISE TRAINING AUGMENTS EPO-INDUCED CHANGES IN EXERCISE TOLERANCE AND FUNCTIONAL CAPACITY OF DIALYSIS PATIENTS Pelagia Koufaki,1 Patrick Naish,2 Thomas Mercer.1 1Centre for Biophysical and Clinical Research into Human Movement, Manchester Metropolitan Univ., Cheshire, United Kingdom; 2Dept. of Renal Medicine, North Staffordshire Hosp. Trust, Staffs, UK

M498 EARLY ANAEMIA CORRECTION WITH EPO: ONE YEAR EFFECTS ON LVH AND PROGRESSION OF CHRONIC RENAL FAILURE (CRF) IN PREDIALYSIS PATIENTS (PTS) Carlo Meloni,1 Carmela Tozzo,1 Valeria Rossi,1 Mauro Borzi,2 Marco Flamini,2 Barbara Della Grotta,1 Annalisa Cecilia,1 Bernardo Rossini,1 Luigi Fontana,2 Carlo Umberto Casciani.1 1U.O.C. Nefrologia e Dialisi, S. Eugenio Hospital, Rome, Italy; 2Clinica Medica, S. Eugenio Hospital, Rome, Italy

M499 LEFT VENTRICULAR STRUCTURE IN NON-DIABETIC PRE- DIALYSIS PATIENTS Khalid Khan,1 Alexander Shutov.2 1Internal Medicine, Khyber Medical Center, Kabal. Swat., NWFP, Pakistan; 2Internal Medicine, Ulyanovsk State University, Ulyanovsk, Russian Federation

M500 THE EFFECT OF A HIGHER HEMATOCRIT (Hct) BY RECOMBINANT HUMAN ERYTHROPOIETIN (rHuEPO) ON QUALITY OF LIFE (QOL) AND ACTIVITY OF DAILY LIFE (ADL) IN PRE-DIALYSIS CHRONIC RENAL FAILURE (CRF)PATIENTS Yoshiharu Tsubakihara,1 Satoru Kuriyama,2 Takashi Shigematsu,3 Toshio Hasegawa,4 Naoki Aoi,5 Shunya Ikeda,6 Shigekazu Haruki,7 Terumasa Hayashi,8 Shozo Koshikawa.9 1Dept. of Nephrology, Osaka Prefectural General Hosp., Osaka, Japan; 2Div. of Nephrology and Hypertension, Jikei Univ. School of Medicine, Tokyo, Japan; 3Div. of Nephrology and Hypertension, Aoto Hosp., Jikei Univ. School of Medicine, Tokyo, Japan; 4Dept. of Nephrology, Sakura National Hosp., Sakura, Chiba, Japan; 5Dept. of Medicine, Aoi Clinic, Nagoya, Japan; 6Dept. of Health Policy and Management, Keio University School of Medicine, Tokyo, Japan; 7Dept. of Kidney Center, Tokyo Women’s Medical Univ., School of Medicine, Tokyo, Japan; 8Dept. of Nephrology, Izumisano City Hosp., Izumisano, Osaka, Japan; 9Dept. of Nephrology, Showa Univ. Fujigaoka Hosp., Yokohama, Kanagawa, Japan

M501 EXPERIENCE WITH LOW DOSE ONCE IN A WEEK RECOMBINANT HUMAN ERYTHROPOIETIN (EPO) THERAPY IN MAINTENANCE HAEMODIALYSIS PATIENT Muhammad Rafiqul Alam,1 A. Khanam,1 M.E. Haque,1 S. Islam,1 Towhidul Islam Waheed,2 H. Rahman,1 H.U. Rashid.1 1Department of Nephrology, BSMMU, Dhaka, Bangladesh; 2Medical Department, Roche Bangladesh Limited, Dhaka, Bangladesh TH MONDAY JUNE 9 POSTERS

M502 EFFECT OF EPO ON RENAL ANAEMIA AND PROGRESSION OF RENAL FUNCTION IN PREDIALYSIS CRF PATIENTS – A STUDY OF 45 PATIENTS Shahidul Islam,1 M.E. Haque,1 Towhidul Islam Waheed,2 M.R. Alam,1 A. Khanam,1 H. Rahman,1 H.U. Rashid.1 1Department of Nephrology, BSMMU, Dhaka, Bangladesh; 2Medical Department, Roche Bangladesh Limited, Dhaka, Bangladesh

M503 EVALUATION OF EPOCIM EFFICACY IN THE TREATMENT OF ANEMIA IN PATIENTS ON CHRONIC HEMODIALYSIS Sepideh Seifi, Mahboob Lessan Pezeshki, Mohammad Reza Khatami, Mitra Mahdavi Mazdeh, Farokh Lagha Ahmadi, Pedram Ahmadpour, Sima Maziar. Nephrology, Tehran University of Medical Science, Tehran, Islamic Republic of Iran

M504 VARIABLE HEMOGLOBIN RESPONSE OF A DIALYZED ANAEMIC PATIENT TO TWO TYPES OF RECOMBINANT ERYTHROPOIETIN. A CASE REPORT WITH TWO EXPOSURES AND TWO RE-CHALLENGE PERIODS Slobodan Milutinovic,1 Djuro Plavljanic,2 Dubravka Orsanic-Brcic.2 1Clinical Pharmacology, Sveti Duh Hospital, Zagreb, Croatia; 2Nephrology and Dialysis, Sveti Duh Hospital, Zagreb, Croatia

M505 PREDICTIVE ROLE OF THE RENIN-ANGIOTENSIN SYSTEM AND ENDOTHELIAL NITRIC OXIDE SYNTHASE GENOTYPES IN ERYTHROPOIETIN REQUIREMENTS Monika Buraczynska, Maria Majdan, Piotr Mierzicki, Andrzej Ksiazek. Nephrology, University Medical School, Lublin, Poland

M506 HAEMOGLOBIN (Hb) RESPONSE TO SUBCUTANEOUS (SC) AND INTRAVENOUS (IV) ADMINSTRATION OF EPOETIN ALFA (EPO) IN IRON REPLETE PATIENTS Murray Leikis,1,2 Annette Kent,2 Gavin Becker,1,2 Lawrence McMahon.1,2 1Dept of Medicine, University of Melbourne, Melbourne, Victoria, Australia; 2Dept of Nephrology, Royal Melbourne Hospital, Melbourne, Victoria, Australia

M507 EXPRESSION OF HEMATOPOIETIC CELL PHOSPHATASE (HCP) IN HEMODIALYSIS PATIENTS Shigeru Akagi,1 Haruo Ichikawa,1 Takashi Kihara,1 Taro Sugimoto,1 Hisanori Morimoto,1 Ai Yano,1 Kazushi Nakao,1 Jun Wada,1 Yoshio Nagake,2 Hirofumi Makino.1 1Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan; 2Department of Nephrology, Okayama Saiseikai General Hospital, Okayama, Japan

M508 PENTOXIFYLLINE THERAPY IMPROVES ERYTHROPOIESIS IN CRF PATIENTS WITH A POOR RESPONSE TO ERYTHROPOIETIC THERAPY Angela C. Cooper,1 Ashraf Mikhail,2 Mark W. Lethbridge,1 David M. Kemeny,1 Iain C. Macdougall.2 1Department of Immunology, King’s College London, London, United Kingdom; 2Department of Renal Medicine, King’s College Hospital, London, United Kingdom

M509 ADEQUATE IRON SUPPLY OVERCOMES HYPORESPONSIVENESS TO EPOETIN THERAPY DUE TO INFLAMMATION A. Habicht, W.H. Hörl. Klinische Abteilung für Nephrologie und Dialyse, Universitätsklinik für Innere Med. III, Vienna, Austria POSTERS MONDAY JUNE 9TH

M510 UNEXPLAINED TRANSFUSION-DEPENDENCE AMONG US END- STAGE RENAL DISEASE (ESRD) PATIENTS W. McClellan,1 W. St. Peter,2,3 J. Liu,3 D. Fife,4 D. Rausch.2,5 1Nephrology, Emory Univ., Atlanta, GA, USA; 2College of Pharmacy, U of MN, Mpls, MN, USA; 3NAS, MMRF, Minneapolis, MN, USA ; 4Epidemiology, J & J PRD, Titusville, NJ, USA; 5Medicine, HCMC, Mpls, MN, USA

M511 MAY RECOMBINANT HUMAN ERYTHROPOIETIN (rHuEPO) INDUCE A SPECIFIC T-CELL-MEDIATED IMMUNE RESPONSE? G.S. Netti,1 V. Petruzzelli,1 A. Blasi,1 L. Roca,1 E. Ranieri,1 S. Di Paolo,1 G. Pertosa,1 G. Grandaliano,1 F.P. Schena,1 L. Gesualdo.2 1Dept. of Emergency and Organ Transplantation, Div. of Nephrology, Univ. of Bari, Bari, Italy; 2Div. of Nephrology, Univ. of Foggia, Foggia, Italy MONDAY

M512 PURE RED CELL APLASIA IN A PATIENT SUFFERING FROM CHRONIC RENAL FAILURE AND UNDERGOING CONSERVATIVE THERAPY Giorgia Russo, Christian Molino, Maurizio Bergami, Alessia Serra, Paolo Gilli, Pier Luigi Bedani. Specialistic Medicine, Division of Nephrology, Ferrara, Italy

M513 ANTIBODY TO ERYTHROPOIETIN SURVILLANCE STUDY IN 5 ONTARIO RENAL CENTRES George Wu,1 Bharat Nathoo,1 David Mendelssohn,2 Sanjay Pandeya,3 Paul Tam.1 1Nephrology, Inst. of Kidney Lifescience Technologies, Toronto, ON, Canada; 2Nephrology, Humber River Regional Hosp., Toronto, ON, Canada; 3Nephrology, Oakville Trafalgar Hosp., Oakville, ON, Canada

M514 DEVELOPING A MEDICARE CLAIMS-BASED APPROACH FOR FINDING PURE RED CELL APLASIA (PRCA) IN END-STAGE RENAL DISEASE (ESRD) CANNOT RELY ON APLASTIC ANEMIA (AA) DIAGNOSIS CODES W. St. Peter,1,2 W. McClellan,3 J. Liu,2 D. Fife,4 Q. Fan,2 D. Rausch.5 1NAS, MMRF, Mpls, MN, USA; 2College of Pharmacy, U of MN, Mpls, MN, USA; 3Nephrology, Emory University, Atlanta, GA, USA; 4Epidemiology, J & J PRD, Titusville, NJ, USA; 5Medicine, HCMC, Mpls, MN, USA

M515 CHARACTERISTICS OF 4792 DIALYSIS PATIENTS ENROLLED IN THE ARANESP® (DARBEPOETIN ALFA) EUROPEAN STUDIES PROGRAMME Alfonso Otero, on Behalf of the Aranesp® European Studies Programme. Servicio de Nefrologia, Hospital Cristal Piñor, Orense, Spain

M516 SAFETY AND EFFICACY OF DARBEPOETIN ALFA IN THE TREATMENT OF ANEMIA IN KIDNEY TRANSPLANT PATIENTS Wael El Haggan, Lydie Vallet, Bruno Hurault de Ligny, Thierry Lobbedez, Myriam Pujo, Béatrice Levaltier, Catherine Ollivier, Jean Philippe Ryckelynck. Dept .of Nephrology and Renal Transpl., Caen Univ. Hosp., Caen, France

M517 CONVERSION OF STABLE DIALYSIS PATIENTS FROM EPOETIN ALFA (EPREX®) TO LESS FREQUENT DOSING WITH DARBEPOETIN ALFA (ARANESP™); EFFICACY AND SAFETY David Churchill,1 Edwin Tofflemire.2 1Nephrology, McMaster University, Hamilton, ON, Canada; 2Nephrology, Queens University, Kingston, ON, Canada

M518 COMPARISON OF Hb LEVELS IN DIALYSIS PATIENTS RECEIVING THREE-TIMES WEEKLY rHuEPO SWITCHED TO ONCE-WEEKLY DARBEPOETIN ALFA: RESULTS OF A RANDOMIZED STUDY F. Carrera, AI Anunciada, C. Nogueira, J.G. Silva. Department of Nephrology, Hospital Sams, Lisbon, Portugal TH MONDAY JUNE 9 POSTERS

M519 ARANESP® (DARBEPOETIN ALFA) MAINTAINS HAEMOGLOBIN (Hb) CONCENTRATIONS IN DIALYSIS PATIENTS WITH EXTENDED DOSING INTERVALS Fernando Carrera, on Behalf of the Aranesp® European Studies Programme. Department of Nephrology, Hospital SAMS, Lisbon, Portugal

M520 ARANESP® (DARBEPOETIN ALFA) INCREASES THE PROPORTION OF DIALYSIS PATIENTS ACHIEVING TARGET HAEMOGLOBIN (Hb) CONCENTRATIONS Juergen Bommer, on Behalf of the Aranesp® European Studies Programme. Dept. of Nephrology, Univ. Hosp., Univ. of Heidelberg, Heidelberg, Germany

M521 SAFETY OF ARANESP® (DARBEPOETIN ALFA) IN DIALYSIS PATIENTS WITH RENAL ANAEMIA—RESULTS OF A GERMAN MULITCENTRE STUDY IN 1502 PATIENTS Juergen Bommer,1 Juergen Wagner.2 1Dept. of Nephrology, Heidelberg Univ. Hosp., Heidelberg, Germany; 2German NESP-20000111 Study Group, Amgen, Inc, Germany

M522 ARANESP® (DARBEPOETIN ALFA) MAINTAINS TARGET HAEMOGLOBIN (Hb) REGARDLESS OF ROUTE OF ADMINISTRATION Francesco Locatelli, on Behalf of the Aranesp® European Studies Programme. Nephrology and Dialysis Dept., “A. Manzoni” Hosp., Lecco, Italy

M523 EFFICACY OF SUBCUTANEOUS ADMINISTRATION OF ARANESP® (DARBEPOETIN ALFA): RESULTS FROM A GERMAN MULTICENTRE TRIAL IN 1502 DIALYSIS PATIENTS W. Kleophas.1,2 1Dialysezentrum, Dusseldorf Dialysis Centre, Dusseldorf, Germany; 2German NESP-20000111 Study Group, Germany

M524 REDUCED FREQUENCY OF ADMINISTRATION OF DARBEPOETIN ALFA (ARANESP®) IN DIALYSIS PATIENTS WITH RENAL ANAEMIA J. Mann,1 U. Fraass.2 1Krankenhaus, Schwabing Hosp., Munich, Germany; 2Amgen GmbH for the German NESP- 20000111 Study Group, Munich, Germany

M525 CERA (CONTINUOUS ERYTHROPOIESIS RECEPTOR ACTIVATOR) FOR THE TREATMENT OF RENAL ANAEMIA: A NEW AGENT WITH AN INNOVATIVE MECHANISM OF ACTION Pascal Bailon,1 Wulf Pahlke,2 Michael Brandt,3 Anton Haselbeck.3 1Pharmaceutical and Analytical R&D, Hoffmann-La Roche Inc, Nutley, NJ, USA; 2Analytics and Support, F. Hoffmann-La Roche, Mannheim, Germany; 3Preclinical Research, F. Hoffmann-La Roche, Penzberg, Germany

M526 PRECLINICAL PHARMACODYNAMICS AND PHARMACOKINETICS OF CERA (CONTINOUS ERYTHROPOIESIS RECEPTOR ACTIVATOR): A NEW ERYTHROPOIETIC AGENT FOR ANAEMIA MANAGEMENT IN PATIENTS WITH KIDNEY DISEASE Nadine Tare,1 Johannes Pill,2 Anton Haselbeck.3 1Discovery Pharmacology, Hoffmann-La Roche Inc, Nutley, NJ, United States; 2Preclinical Pharmacology, F. Hoffmann-La Roche, Mannheim, Germany; 3Preclinical Research, F. Hoffmann-La Roche, Penzberg, Germany

M527 PHASE I STUDIES OF THE NEW ERYTHROPOIETIC AGENT, CERA (CONTINUOUS ERYTHROPOIESIS RECEPTOR ACTIVATOR): DEMONSTRATION OF A DOSE-DEPENDENT RESPONSE Bruno Reigner, Paul Jordan, Anne Pannier, Frank C. Dougherty. Clinical Pharmacology and Biostatistics, F. Hoffmann-La Roche, Basel, Switzerland POSTERS MONDAY JUNE 9TH

DIALYSIS- CLINICAL; ADEQUACY AND MODELLING

M528 MONITORING KT/V OF HEMODIALYSIS BY ON-LINE CLEARENCE MONITORING Chaoyang Ye, Changlin Mei, Shu Rong. Department of Nephrology, Changzheng Hospital, Shanghai, China

M529 PROPOSAL OF A MODEL FOR QUALITY IMPROVEMENT IN DIALYSIS Francesco Gaetano Casino,1 Teodoro Lopez,1 Carlo Basile,2 Rosa Giordano,2 Michele Virgilio,3 Simona Brusasco,3 Felice Iannuzziello,4 Vittorio Ricchiuti,4 Erasmo Buongiorno,5 Vittorio MONDAY Strazzeri,5 Maria Perniola,6 Paolo Venerito.6 1Nephrology Unit, Osp.Madonna delle Grazie, Matera, Italy; 2Nephrology Unit, Osp. Civile, Martina Franca, Taranto, Italy; 3Nephrology Unit, Osp. Civile, Molfetta, Bari, Italy; 4Nephrology Unit, Osp. Civile, Pisticci, Matera, Italy; 5Nephrology Unit, Osp. F.Ferrari, Casarano, Lecce, Italy; 6Nephrology Unit, Centro SS Medici, Taranto, Italy

M530 HEMODIALYSIS PRODUCT AS INDEX OF . STUDY ON 57 PATIENTS Guillermo Rojas, Maria-Cristina Alvarez, Mauricio Loo, Hernan Aguirre. Departamento de Investigacion y Desarrollo, Centrodialisis Ltda., Vina del Mar, Region de Valparaiso, Chile

M531 CLEARED UREA VOLUME IN HEMODIALYSIS ACCORDING TO THE KINETIC MODEL AND THE UREA REMOVED FROM THE DIALYZATE Franck Pinares, Javier Cieza, Luis Estremadoyro, Walter Castillo. Medicina, Medical Services Corpac, Lima, Peru

M532 COMPARISON OF PRESCRIBED AND DELIVERED DOSE OF DIALYSIS USING ANTHROPOMETRICALLY AND BIOELETRICALLY MEASURED PATIENTS VOLUMES Wojciech Zaluska,1 Daniel Schneditz,2 Andrzej Ksiazek.1 1Department of Nephrology, Medical University of Lublin, Lublin, Poland; 2Department of Physiology, Karl-Franzes University, Graz, Austria

M533 PHOSPHATE REMOVAL IN HEMODIALYSIS A TIME DEPENDANT FACTOR Indralingam Vaithilingam, Kevan Polkinghorne, Robert Atkins, Peter Kerr. Nephrology, Monash Medical Centre, Clayton, VIC, Australia

M534 THE FREQUENCY OF EXPOSURE TO A DIALYSIS DOSE OF LESS THAN SINGLE POOL (sp) Kt/V OF 1.2 PREDICTS DECREASED SURVIVAL IN HEMODIALYSIS PATIENTS Brian Walters,1,2 Phillip Pennell,2 Jörgen Hegbrant,1 Jose Nabut,1 Juan Bosch.1 1Outcomes Research, Gambro Healthcare, Ft Lauderdale, FL, United States; 2Division of Nephrology, University of Miami, Miami, FL, USA

M535 ASSOCIATION BETWEEN HD ADEQUACY AND MALNUTRITION - INFLAMMATION AND ATHEROMATOSIS SEPARATELY OR IN COMBINATION AS MIA-SYNDROME: WHAT MAY CAUSE WHAT? A. Zerva,1 D. Moutzouris,1 A. Potamianou,2 K. Koroneos,3 D.-A. Moutzouris,1 A. Kokkona,1 E. Stavroulaki,1 E. Tsiroglou,2 Th. Agrafiotis.1 1Nephrology Dept., “Asklepieion” General Hosp. Athens, Greece; 2Hematology Dept., “Asklepieion” General Hosp., Athens, Greece; 3Radiology Dept., “Asklepieion” General Hosp., Athens, Greece TH MONDAY JUNE 9 POSTERS

M536 ANALYSIS OF URR IN THE 1999 UK INCIDENT RENAL REPLACEMENT THERAPY COHORT: 2 YEAR SURVIVORS VERSUS NON-SURVIVORS. DATA FROM THE UK REGISTRY David Ansell,1 Eric Will,2 Kate Thomas,1 Terry Feest.1 1UK Renal Registry, Southmead Hopital, Bristol, United Kingdom; 2Renal Unit, St James’ University Hospital, Leeds, United Kingdom

M537 ASSESSING DIALYSIS DOSE IN ACUTE RENAL FAILURE (ARF) PATIENTS (PTS) Francesco G. Casino,1 Mark R. Marshall.2 1Nephrology Unit, Osp. Madonna delle Grazie, Matera, Italy; 2Dept. of Renal Medicine, Middlemore Hospital, Auckland, New Zealand

M538 DIALYTIC ADEQUACY IN PTS WITH DIFFICULT VASCULAR ACCESS: IS IT ALWAYS NECESSARY TO PROLONG TREATMENT TIME? Salvatore Mandolfo,1 Raffaella Bucci,1 Paolo Cogliati,2 Stefania Cortesi,2 Enrico Imbasciati.1 1Renal Unit, Ospedale Maggiore, Lodi, LO, Italy; 2Scientific, Fresenius Medical Care, Palazzo Pignano, CR, Italy

M539 RELATIONSHIP BETWEEN KT/V AND SOLUBLE FAS IN HEMODIALYSIS WITH DIFFERENT TYPES OF MEMBRANES Lygeri Soubassi,1 Dimitrios Chaniotis,1 Efi Protonotariou,2 Sofia Soubassi,1 Stelios Zerefos,1 Antonis Lagouranis,1 Angeliki Sarandakou,2 Nikolaos Zerefos.1 1Dpt. of Nephrology, “Alexandra” Hosp., Athens, Greece; 2Hormone Laboratory, “Aretaieion” Hosp., Athens, Greece

M540 ACTIVELY PERMEABLE EXTRAVASCULAR WATER (APEW) – NEW PARAMETER FOR ASSESSMENT OF HAEMODIALYSIS DELIVERY Mario Bonomini,1 Vittorio Sirolli,1 Walter Bisello,1 Silvio Di Stante,1 Luigi Amoroso,1 Victor Kislukhin,2 Nikolai Krivitski.2 1Nephrology, Univ. of Chieti, Chieti, Italy; 2Transonic Systems Inc., Ithaca, NY, United States

M541 FEASIBILITY STUDY OF THE DIALYSIS ADEQUACY EBPG- GUIDELINE IMPLEMENTATION IN THE CZECH REPUBLIC Tomas Jirka,1 Petr Táborsky,1 Jiri Vlasák,1 Ludmila Kotasková,1 Zuzana Pavliková,1 Daniele Marcelli,2 Mihály Tapolyai.2 1Fresenius MC - DS Prague, Fresenius MC - DS Prague, Prague, Czech Republic; 2Clinical Management Europe, Fresenius MC, Bad Homburg, Germany

M542 eKT/V AND DURING HEMODIALYSIS AND ON-LINE HEMODIAFILTRATION: A PROSPECTIVE STUDY Willy Lornoy, I. Becaus, J.M. Billiouw, J. De Meester, B. Van Vlem, G. Van Leuven, M. Vermaut. Renal Unit, O.L.Vrouwziekenhuis, Aalst, Oost-Vlaanderen, Belgium

M543 MULTIVARIATE RISK ASSESSMENT FOR HYPERTENSION DURING UREA KINETICS MODELLED CHRONIC HEMODIALYSIS Jose Mario Oliveira,1 Mauro Alves,2 Jocemir Lugon,2 Luciana Abreu,2 Luiz Romeo.2 1Dept. of Health Sciences, Univ. of Beira Interior, Covilha, Castelo Branco, Portugal; 2Dept. of Clinical Sciences, Univ. Federal Fluminense, Niteroi, Rio de Janeiro, Brazil

M544 WHICH IS THE OPTIMAL METHOD TO MEASURE UREA DISTRIBUTION VOLUME FOR CONDUCTIVITY BASED Kt/V Andreas Wuepper,1 James Tattersall,2 Elizabeth Lindley,2 Lorraine Edwards,3 Helen Inglis,2 Matthias Kraemer.1 1Research & Development, Fresenius Medical Care, Bad Homburg, Germany; 2Renal Unit, St James University Hospital, Leeds, United Kingdom; 3Northern General Hospital, Sheffield Kidney Institute, Sheffield, United Kingdom POSTERS MONDAY JUNE 9TH

M545 INFLUENCE OF BIKING DURING HEMODIALYSIS ON DIRECTLY QUANTIFIED REMOVAL OF VARIOUS COMPOUNDS Juergen Bommer, Corinna Bommer. Sektion Nephrologie, Medizinische Universitätsklinik, Heidelberg, Germany

M546 PROTEIN INTAKE CORRELATES WITH VISCERAL ORGAN VOLUME AND BOTH MEASURES ARE INDEPENDENT OF TOTAL (TBW): LESS DILUTION OF VISCERAL UREMIC TOXINS MAY ACCOUNT FOR INCREASED MORTALITY IN SMALLER HEMODIALYSIS (HD) PATIENTS Nathan Levin,1 Shubho Sarkar,1 Frank Gotch,1 Steven Heymsfield,3 George Kaysen,2 Roger Greenwood.1 1Nephrology, Renal Research Inst./Beth Israel Medical Center, New York, NY, USA; 2Div. of Nephrology/Dept.of Internal Medicine, Univ. of California, Davis, MONDAY CA, USA; 3Body Composition Unit, St. Lukes Hosp., New York, NY, USA

M547 THE DOMINANT ROLE AND RISK FACTORS FOR ISOLATED SYSTOLIC HYPERTENSION DURING CHRONIC UREA KINETICS MODELLED HEMODYALYSIS Jose Mario Oliveira, Jocemir Lugon, Luiz Romeo, Luciana Abreu, Fatima Bandeira, Mauro Alves. 1Dept. of Health Sciences, Univ. da Beira Interior, Covilha, Portugal; 2Dept. of Clinical Medicine, Univ. Federal Fluminense, Niteroi, Rio de Janeiro, Brazil; 3CDR - Botafogo, Fresenius MC, Rio de Janeiro, Brazil

M548 SURVIVAL IMPROVES WITH HIGHER DIALYSIS DOSE: RESULTS FROM THE CENTERS FOR MEDICARE & MEDICAID ESRD CLINICAL PERFORMANCE MEASURES PROJECT Mamta Agarwal,1 Greg Russell,2 Diane Frankenfield,3 Michael Rocco.1 1Section on Nephrology, Wake Forest Univ.School of Medicine, Winston-Salem, NC, USA; 2Dept. of Public Health Sciences, Wake Forest Univ. School of Medicine, Winston-Salem, NC, USA; 3Centers for Medicare & Medicaid Services, Baltimore, MD, USA

M549 HIGH LEVELS OF DIALYSIS DOSE (eKt/V) ARE ASSOCIATED WITH LOWER MORTALITY AMONG FEMALES BUT NOT AMONG MALES IN THE DOPPS Friedrich Port,1 Robert Wolfe,2 Keith McCullough,1 Juergen Bommer,3 Akira Saito,4 Shunichi Fukuhara,5 Kiyoshi Kurokawa,4 Jose Miguel Cruz,6 David Goodkin,1 Eric Young.7 1DOPPS, URREA, Ann Arbor, MI, USA; 2Biostatistics/KECC, Univ. of Michigan, Ann Arbor, MI, USA; 3Nephrology, Univ. of Heidelberg, Heidelberg, Germany; 4Medicine, Tokai Univ., Kanagawa, Japan; 5Medicine, Kyoto Univ., Kyoto, Japan; 6Nephrology, Hosp. Univ. La Fe, Valencia, Spain; 7Nephrology, VAMC/Univ. of Michigan, Ann Arbor, MI, USA

M550 THE EFFECT OF TIME (T) AND FREQUENCY (FR) INCREASE ON WEEKLY DIALYSIS DOSE(WDD):A COMPUTER-SIMULATION APPROACH Rodolfo Valtuille,1 Manuel Sztejnberg,2 Elmer Fernandez,2 Peter Wilshaw.2 1Dialysis, Fresenius Medical Care, Burzaco, Buenos Aires, Argentina; 2Bioengineering, Favaloro University, Buenos Aires, Argentina

M551 THE PREDICTIVE POWER OF HEMODIALYSIS PRODUCT (HDP) — A PILOT STUDY Attilio Di Benedetto,1 Francesco Pavese,1 Giancarlo Marinelli,1 Carla Lamberti,1 Caterina Saviano,1 Fausto Fusco,1 Anna Rita Oggero,1 Eugenio Guariglia,1 Mihaly Tapolyai,2 Daniele Marcelli,2 NephroCare Study Group.1 1Direzione Medica, Fresenius Medical Care - NephroCare Italy, Naples, Italy; 2Clinical Management Europe, Fresenius Medical Care, Bad Homburg, Germany TH MONDAY JUNE 9 POSTERS

M552 ICREASING DIALYSIS DOSE CAN REDUCE BLOOD PRESSURE IN CHRONICALLY HYPERTENSIVE HEMODIALYSIS PATIENTS Sarwar Iqbal,1 A. Siddiqi,2 M.I. Hossain,3 M.H. Rahman,1 H.U. Rashid,1 M. Iqbal.4 1Nephrology, Bangabandhu Sheikh Mujib Medical University(BSMMU), Dhaka, Bangladesh; 2Cardiology, BSMMU, Dhaka, Bangladesh; 3Radiology & Imaging, BSMMU, Dhaka, Bangladesh; 4Nephrology, NIKDU, Dhaka, Bangladesh

M553 SURVIVAL AS AN INDEX OF DIALYSIS ADEQUACY. THE IMPACT OF PRIORIZING CONTINUOUS ADEQUATE ON OUTCOME Olimpia Ortega, Paloma Gallar, Isabel Rodriguez, Aniana Oliet, Agustín Carreño, Milagros Ortiz, Luz Lozano, Ana Vigil. Nephrology, Hospital Severo Ochoa, Leganes, Madrid, Spain

M554 WHOLE BODY BIOIMPEDANCE MEASUREMENTS OF EXTRACELLULAR VOLUME (ECV) FOR DRY WEIGHT ESTIMATION (DW) IN HEMODIALYSIS (HD) PATIENTS Wojciech Zaluska, Teresa Malecka, Piotr Ksiazek, Andrzej Ksiazek. Dept. of Nephrology, Medical University of Lublin, Lublin, Poland

M555 HYPERTENSION AND HYPERHYDRATION IN HEMODIALYSIS PATIENTS ASSESSED BY MULTIFREQUENCY BIOIMPEDANCE MEASUREMENTS Botond Csiky,2 Tibor Vas,1 Judit Nagy.1 1Nephrological Center and 2nd Dept. of Med., University Medical School of Pécs, Pécs, Baranya, Hungary; 2FMC, Dialysis Center, Pécs, Baranya, Hungary

M556 COLOR M-MODE DOPPLER FLOW PROPAGATION VELOCITY IS A HYDRATION INSENSITIVE DIASTOLIC INDEX IN HEMODIALYSIS PATIENTS Alexander Shutov,1 Viacheslav Mastykov,2 Olga Edigarova,2 Viktor Mukhorin.2 1Dept. of Internal Medicine, Ulyanovsk State Univ., Ulyanovsk, Russian Federation; 2Ulyanovsk Regional Hosp., Ulyanovsk, Russian Federation

M557 INTERDIALYTIC VARIATIONS OF BLOOD VOLUME AND TOTAL BODY WATER IN UREMIC PATIENTS TREATED BY DIALYSIS Ezio Movilli, Silvia Cassamali, Camilla Maffei, Corrado Camerini, Giuliano Brunori, Roberto Zubani, Giovanni Carlo Cancarini, Rosario Maiorca. Nephrology, University and Spedali Civili, Brescia, Italy

M558 DRY BODY WEIGHT (dbw) IN HEMODIALYSIS: A NEW WAY TO MEASURE IT Giorgio Romei Longhena,1 Ferruccio Miglietta,2 Gaia Tonani,2 Luca Maltagliati,1 Renato Savino,1 Roberto Colombo,1 Roberto Cimino,1 Francesco Masi,1 Anna Manfredi,1 Maria Laura Costantino,2 Ugo Teatini.1 1Renal Unit, Bollate Hospital, Bollate, Milano, Italy; 2Dipartimento Bioingegneria, Università Politecnico, Milano, Italy

M559 COMPARATIVE MEASUREMENT OF FLUID COMPARTMENT VOLUMES BY SEGMENTAL AND WHOLE BODY BIOIMPEDANCE (SBIA, WBIA) AND TRACER DILUTION IN HEMODIALYSIS PATIENTS UNDERGOING Shubho Sarkar,1 Fansan Zhu,1 Charoen Kaitwatcharachai,1 Alice Morris,1 Jack Wang,3 George Kaysen,2 Steve Heymsfield,3 Roger Greenwood,1 Frank Gotch,1 Nathan Levin.1 1Nephrology and Hypertension, Beth Israel Medical Center/Renal Research Institute, New York, NY; 2Division of Nephrology, Dept. of Internal Medicine, University of California, Davis, CA; 3Body Composition Unit, St. Lukes Hospital, New York, NY, POSTERS MONDAY JUNE 9TH

M560 ESTIMATION OF EXTRACELLULAR AND INTRACELLULAR FLUID VOLUME IN HEMODIALYSIS PATIENTS BY COMBINATION OF SEGMENTAL BIOIMPEDANCE ANALYSIS (SBIA) AND MRI TECHNIQUE Fansan Zhu,1 George Kaysen,2 Shubho Sarkar,1 Charoen Kaitwatcharachai,1 Edware F. Leonard,3 Jack Wang,4 Steve Heymsfield,4 Roger Greenwood,1 Frank Gotch,1 Nathan W. Levin.1 1Dialysis, Renal Research Institute and Beth Israel Medical Center, New York, NY, United States; 2Division of Nephrology, University of California,, Davise, CA, United States; 3Dept.of ChemicalEngineering, Columbia University, New York, NY, United States; 4Body Composition Unit, St.Lukes Hospital, New York, NY, United States

M561 THE INFLUENCE OF PLASMA VOLUME STATUS ON BLOOD MONDAY PRESSURE CONTROL IN CHRONIC HEMODIALYSIS PATIENTS Salwa Ibrahim,1 Ahmed El-Taweel,2 Dawlat Belal.1 1Department of Medicine, 2Department of Chemical Pathology, Cairo University, Cairo, Egypt TH MONDAY JUNE 9 POSTERS CARDIOVASCULAR RISK IN ESRD, CARDIAC HYPERTROPHY AND ATHEROSCLEROSIS

M562 QT INTERVAL VARIABILITY AND MORTALITY IN HAEMODIALYSIS PATIENTS Ljiljana Suric Lambic, Steva Pljesa, Vesna Djurkovic, Rodoljub Markovic, Ljiljana Komadina. Department of Nephrology, University Teaching Hospital Zemun, Beograd, Serbia, Yugoslavia

M563 QT PROLONGATION IN END STAGE RENAL DISEASE AND CARDIOVASCULAR CONTROLS Andrew Koren, Jonathan Winston. Department of Renal Diseases, Mount Sinai Medical Center, New York, NY, United States

M564 HEMODIALYSIS-ASSOCIATED INCREASES IN QT DISPERSION AND ACTIVATION RECOVERY INTERVAL DISPERSION ARE RELATED TO CHANGES IN THE RENIN-ANGIOTENSIN SYSTEM IN PATIENTS UNDERGOING MAINTENANCE DIALYSIS Tsuneo Murasawa, Yukinao Sakai, Takuya Ono, Goh Isaji, Ken-ichi Amitani, Tomoyoshi Yamaguchi, Tomohiro Nishigaki, Kazuo Munakata. Internal Medicine, Nippon Medical School Hospital 2, Kawasaki, Kanagawa, Japan

M565 VALUE OF CORRECTED QT DISPERSION PRE- AND POST- HEMODIALYSIS TO IDENTIFY PATIENTS AT INCREASED RISK OF CARDIOVASCULAR MORTALITY DURING THREE YEARS FOLLOW UP Aria Jenabi, Ahmad Mooraki, Ali Shangarf, Mosadegh Jabbari, Behrooz Broumand. Nephrology Department, Rasool Akram Medical Center,Iran University of Medical Sciences, Tehran, Islamic Republic of Iran

M566 QTc INTERVAL SHORTENING IS RELATED TO BLOOD Ca++ INCREASE DURING ACETATE FREE BIOBILTRATION Michele Buemi,1 Lorena Nostro,1 Fulvio Floccari,1 Emanuele Aloisi,1 Alessandra Crisafulli,1 Riccardo Ientile,2 Antonio Barilla,1 Carmela Aloisi,1 Adolfo Romeo,1 Francesco Corica.1 1Department of Internal Medicine, Chair of Nephrology,, Messina, Italy; 2Institute of Clinical Biochemistry, Messina, Italy

M567 HEART RATE AS INDEPENDENT PROGNOSTIC FACTOR FOR CARDIOVASCULAR MORTALITY AMONG NORMOTENSIVE HEMODIALYZED PATIENTS WITH NORMAL LEFT VENTRICULAR SYSTOLIC FUNCTION Gennaro Cice,1 Attilio Di Benedetto,2 Daniele Marcelli,3 Antonello D’Andrea,1 Salvatore D’Isa,1 Luigi Ferrara,1 Pina Elvira Russo,1 Raffaele Calabrò.1 1Chair of Cardiology, Second University of Naples, Naples, Italy; 2Medical Direction, Fresenius Medical Care - NephroCare Italy, Naples, Italy; 3Clinical Management Europe, Fresenius Medical Care, Bad Homburg, Germany

M568 LONG-TERM FOLLOW-UP OF HEMODIALYSIS PATIENTS HAVING CONCOMITANT ATRIAL FIBRILLATION M.C. Sanchez-Perales,1 E. Vazquez,2 M.J. Garcia-Cortes,1 F.J. Borrego,1 J. Borrego,1 P. Perez del Barrio,1 A. Liebana,1 J.M. Gil,1 G. Viedma,1 V. Perez Bañasco.1 1Nefrologia, Complejo Hospitalario de Jaen; 2Cardiologia, Jaen, Spain POSTERS MONDAY JUNE 9TH

M569 QT AND QTC IN STANDARD HEMODIALYSIS Maurizio Garozzo, Salvatore Urso, Filippo Milone, Giovanni Giorgio Battaglia. Unità Operativa di Nefrologia e Dialisi, AUSL 3 - Ospedale S. Marta e S. Venera di Acireale, Acireale, Catania, Italy

M570 ATRIAL FIBRILLATION IS ASSOCIATED WITH INCREASED P WAVE DISPERSION IN HEMODIALYSIS PATIENTS Giovanni Maglionico,1 Enrico Niutta,1 Anna Malnati,1 Mirco Belingheri,1 Giuliana Macchi,2 Luciana Baratelli,1 Giacomo Colussi.1 1Department of Nephrology, Varese General Hospital, Varese, Italy; 2Department of Cardiology, University of Varese, Varese, Italy MONDAY TH MONDAY JUNE 9 POSTERS OXIDATIVE STRESS - REACTIVE OXYGEN SPECIES, AGE’S

M571 UPREGULATION OF RECEPTOR FOR ADVANCED GLYCATION END PRODUCTS: ROLE IN THE MONOCYTE ACTIVATION IN CHRONIC RENAL FAILURE Fan Fan Hou, Hao Ren, Xun Zhang. Division of Nephrology, Nanfang Hospital, Guangzhou, GuangDong, China

M572 SEPARATION AND CHARACTERIZATION OF FLUORESCENT SERUM FRACTIONS IN HEMODIALYSIS PATIENTS Joerg Wagner, Ulrike Eismann, Sybille Franke, Guenter Stein. Internal Medicine IV, Friedrich Schiller University, Jena, Germany

M573 THE INFLUENCE OF AGE ON MATRIX GLA PROTEIN mRNA EXPRESSION IN VASCULAR SMOOTH MUSCLE CELL Naohisa Hirasaka, Yoshinori Tone, Chiaki Yamashita, Yoshinobu Minami, Xiang-Ming Liang, Haruhisa Otani, Masatoshi Mune, Susumu Yukawa. Third Department of Internal Medicine, Wakayama Medical College, Wakayama City, Wakayama, Japan

M574 THE INFLUENCE OF OXIDATIVE STRESS, INFLAMMATION MARKERS AND GROWTH FACTORS ON CORONARY CALCIFICATION PROGRESSION IN PATIENTS ON MAINTENANCE HEMODIALYSIS Maciej Drozdz,1 Andrzej Krasniak,1 Dorota Szumilak,3 Grzegorz Chmiel,1 Martyna Michalek,1 Wieslawa Tracz,2 Piotr Podolec,2 Mieczyslaw Pasowicz,2 Tilman Drueke,3 Beatrice Descamps- Latscha,3 Ziad Massy,3 Wladyslaw Sulowicz.1 1Chair and Dept of Nephrology, Jagiellonian University, Krakow, Poland; 2Institute of Cardiology, Krakow, Poland; 3Inserm U507 and Biochemistry Laboratory, Paris, France

M575 CELLULAR HYPOXIA – A POSSIBLE CAUSE OF MYOCARDIAL DAMAGE IN CHRONIC RENAL FAILURE PATIENTS UNDERGOING HEMODIALYSIS TREATMENT Maria Wanic-Kossowska, Mikolaj Kobelski, Elzbieta Pawliczak, Lidia Koziol, Stanislaw Czekalski. Department of Nephrology, University of Medical Sciences, Poznan, Poland

M576 EVALUATION OF A REDOX STATE OF HUMAN SERUM ALBUMIN IN CHRONIC DIALYZED PATIENTS Kazuhiko Kawahara,1 Jun Minakuchi,1 Kenji Shima,1 Shu Kawashima,1 Hiroyasu Tsukaguchi,2 Keiko Yasukawa,3 Akira Saito.4 1M.D., Kawashima Hospital, Tokushima, Japan; 2M.D., Tokushima University, Tokushima, Japan; 3G.A., Asahi Kasei Coporation, Chiyoda, Tokyo, Japan; 4Division of Nephrology and Metabolism, Tokai Medical School, Isehara, Kanagawa, Japan

M577 VITAMINS AND STATINS ARE ASSOCIATED WITH SURVIVAL IN PATIENTS WITH END-STAGE RENAL DISEASE: A FOUR YEAR PROSPECTIVE STUDY Ute Domroese,1 Jutta Dierkes,2 Sabine Westphal,2 Claus Luley,2 Klaus Hinrich Neumann.1 1University Hospital Magdeburg, Division of Nephrology, Magdeburg, Germany; 2University Hospital Magdeburg, Institute of Clinical Chemistry, Magdeburg, Germany POSTERS MONDAY JUNE 9TH

M578 OXIDATIVE STRESS IN HEMODIALYSIS PATIENTS: SHORT TERM EVALUATION OF TWO ANTIOXIDANT TREATMENTS Christophe Bovy,1 Joel Pincemail,2 Olivier Golinval,1 Jean-Olivier Defraigne,2 Bernard Dubois,1 Georges Rorive.1 1Nephrology and Dialysis, CHU Liège, Liège, Belgium; 2Experimental Surgery Laboratory, CHU Liège, Liège, Belgium

M579 THE ANTIOXIDANT, ACETYLCYSTEINE, REDUCES PLASMA OXIDIZED LOW DENSITY LIPOPROTEIN CONCENTRATIONS IN PATIENTS WITH ENDSTAGE RENAL DISEASE J. Jankowski, M. Wissdorff, M. van der Giet, W. Zidek, M. Tepel. Med. Klinik IV, Univ.-Klinik Benjamin Franklin, Berlin, Germany

M580 STUDY OF OXIDATIVE DNA DAMAGE IN CHRONIC RENAL PATIENTS ON PERITONEAL DIALYSIS AND HEMODIALYSIS MONDAY SUPPLEMENTED WITH VITAMIN E Fernanda Aparecida Domenici,1 Maria Terezinha Infantosi Vannucchi,2 Helio Vannucchi,1 Monica Silva de Sousa Meirelles,1 Alceu Afonso Jordão, Jr.,1 Beatriz Magakawa.2 1Clínica Médica, Faculdade de Medicina de Ribeirão Preto-USP, Ribeirão Preto, São Paulo, Brazil; 2Serviço de Nefrologia de Ribeirão Preto, SENERP, Ribeirão Preto, São Paulo, Brazil

M581 BETTER EFFECTS OF VITAMIN E COATED DIALYSIS MEMBRANE (CL-EE) ON LIPID PEROXIDATION IN DIABETIC PATIENTS THAN NON-DIABETIC PATIENTS Noritomo Itami,1 Seiji Ohira,1 Yasushige Tsuji,2 Yoshio Katsuki,2 Hiromi Hamada,2 Jouji Takada.2 1Kidney Center, Nikko Memorial Hosp., Muroran, Hokkaido, Japan; 2Dept. of Surgery, Nikko Memorial Hosp., Muroran, Hokkaido, Japan

M582 VITAMINS E & C INCREASE PLASMA LDL OXIDATION LAG TIME (LOLT) BUT NOT TOTAL ANTIOXIDANT CAPACITY (TAC) IN CHRONIC HAEMODIALYSIS PATIENTS (CHD PTS) Raul Rodriguez,1 Ray Fernando,2 Bertha Martinez,1 Zac Varghese,2 Narciso Molina,1 Gita Turikhia,2 J.F. Moorhead.2 1Nephrology, Hospital Especialidades Siglo XXI IMSS, México city, Mexico; 2Renal Research Laboratory, Royal Free Hospital, London, United Kingdom

M583 WARNING: DIALYSIS PATIENTS AT RISK OF SCURVY? Daniela Bergamo,1 Paola Massarenti,2 Manuel Burdese,1 Luisa Sandri,1 Daniela Pauletto,2 Elisa Sofi,2 Paola Golzio,2 Caterina Canavese.1 1Chair of Nephrology, University of Turin, Turin, Italy; 2Laboratory of Clinical Nutrition, San Giovanni Battista Hospital, Turin, Italy

M584 INTRAVENOUS IRON-INDUCED LIPID PEROXIDATION IS ENHANCED BY SIMULTANEOUS ASCORBIC ACID ADMINISTRATION IN HEMODIALYSIS (HD) PATIENTS Jaromir Eiselt,1 Jaroslav Racek,2 Ladislav Trefil,2 Pavel Stehlik,2 Karel Opatrny.1 1Dept. of Internal Medicine I, Charles Univ. School of Medicine, Plzen, Czech Republic; 2Dept. of Biochemistry and Laboratory Diagnostics, Charles Univ. School of Medicine, Plzen, Czech Republic

M585 INTRAVENOUS IRON INCREASES PREGNANCY-ASSOCIATED PLASMA PROTEIN-A AND ADVANCED OXIDATION PROTEIN PRODUCTS LEVELS IN CHRONIC HAEMODIALYSIS PATIENTS Magdalena Horejsi,1 Marta Kalousova,2,3 Sylvie Sulkova,1 Jirina Soukupova,3 Lenka Fialova,2 Ivan Matous Malbohan,2,3 Tomas Zima.3 1Dept. of Medicine Strahov, General Univ. Hosp. and 1st Faculty of Medicine, Charles Univ., Prague, Czech Republic; 2Inst.of Medical Biochemistry, General University Hospital and 1st Faculty of Medicine, Charles University, Prague, TH MONDAY JUNE 9 POSTERS

M586 REACTIVE OXYGEN SPECIES IN HEMODIALYSIS PATIENTS C. Rinder, J. Beige, W. Zidek, M. Tepel. Med. Klinik IV, Univ.-Klinik Benjamin Franklin, Berlin, D, Germany

M587 THE EFFECT OF LIGHT-SHIELDED BLOOD CIRCUIT ON OXIDATIVE STRESS ON DNA OF HUMAN BLOOD Takahiro Kuragano, Tsutomu Kuno, Chii Yamamoto, Yuji Nagura, Susumu Takahashi, Koichi Matsumoto, Katsuo Kanmatuse. Nihon University School of Medicine, Second Department of Internal Medicine, Itabashi-Ku, Tokyo, Japan

M588 INFLUENCE OF FOLATE ON HOMOCYSTEINE (Hcy) LEVELS AND PARAMETERS OF OXIDATIVE STRESS IN PATIENTS WITH END-STAGE RENAL DISEASE AND AFTER KIDNEY TRANSPLANTATION Eugenie Vesela,1 Jaroslav Racek,2 Marika Rackova,2 Hana Rusnakova,2 Ladislav Trefil,2 Jiri Chvojka.1 1Haemodialysis Centre EuroCare, Military Hospital, Plzen, Czech Republic; 2Institute of Clinical Biochemisty and Laboratory Diagnostics, Charles University Hospital, Plzen, Czech Republic

M589 REDUCED APOPTOSIS AND OXIDATIVE STRESS WITH THE SMC MEMBRANE COMPARED TO CONVENTIONAL SYNTHETIC LOW-FLUX MEMBRANES IN VITRO Nicole Sauer, Horst-Dieter Lemke. Research and Development, Membrana GmbH, Obernburg, Germany

M590 OXIDATIVE STRESS IN HEMODIALYSIS PATIENTS AND INFLUENCE OF SUPPLEMENTATION THERAPY ON THEIR LIPID PEROXIDATION LEVEL Beti Dejanova,1 Petar Dejanov,2 Vesela Maleska,1 Suncica Petrovska,1 Aleksandar Sikole.2 1Department of Physiology, Medical Faculty, Skopje, Macedonia, The Former Yugoslav Republic of; 2Department of Nephrology, Clinical Center, Skopje, Macedonia, The Former Yugoslav Republic of Macedonia

M591 ANTI-OXIDANTS IN HEMODIALYSIS PATIENTS AND RENAL TRANSPLANT RECIPIENTS; THEIR RELATIONSHIP TO OSMOTIC FRAGILITY OF RED BLOOD CELLS Hassan Argani,1 Mohammad Nouri,2 Mohammad Rahbani,2 Farah Rokhforooz.2 1Division of Renal Transplantation of Emam Hospital, Drug Applied Research Center; Tabriz Medical University, Tabriz, East Azarbayejan, Islamic Republic of Iran; 2Department of Clinical Biochemistry, Faculty of Medicine of Tabriz Medical University, Tabriz, East Azarbayejan, Islamic Republic of Iran

M592 EFFECT OF STATINES ON SERUM LIPID, LIPD PEROXIDES AND TOTAL ANTIOXIDANT CONCENTERTATIONS IN HEMODIALYSIS PATIENTS Hassan Argani,1 Nadereh Rashtchizade,2 Amir Ghorbanihaghjoo,2 Mohammad Rahbaninobar,2 Abbas Khonakdar.2 1Dialysis Center of Emam Hospital, University of Tabriz Medical Siences, Tabriz, East Azarbayejan, Islamic Republic of Iran; 2Drug Applied Research Center, Biochemisty faculty of University of Tabriz Medical Siences, Tabriz, East Azarbayejan, Islamic Republic of Iran

M593 THE EFFECTS OF ERYTHROPOIETIN ON THE OXIDATIVE STRESS IN HEMODIALYSIS PATIENTS Cristina Capusa,1 Nicolae Ursea,1 Irina Stoian,2 Gabriel Mircescu,1 Liliana Garneata,1 Magda Maracine,2 Carmen Barbulescu,1 Bogdan Petrescu.1 1Nephrology, Dr Carol Davila Hospital of Nephrology, Bucharest, Romania; 2Biochemistry, Carol Davila University of Medicine, Bucharest, Romania POSTERS MONDAY JUNE 9TH

M594 INCREASED PRODUCTION OF METHYGUANIDINE, AN OXIDATIVE MARKER, DURING HAEMODIALYSIS Sohji Nagase, Aki Hirayama, Atsushi Ueda, Mariko Inoue, Kenji Takada, Takaaki Oteki, Mami Obara, Akio Koyama. Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan

M595 CHOLESTERYLESTER HYDROPEROXIDE, BUT NOT PHOSPHATIDYLCHOLINE HYDROPEROXIDE, IS DECREASED BY HEMODIALYSIS Mami Obara,1 Aki Hirayama,1 Sohji Nagase,1 Michihiro Gotoh,2 Takaaki Oteki,1 Kenji Takada,1 Mariko Inoue,1 Atsushi Ueda,3 Akio Koyama.1 1Dept. of Nephrology, Inst. of Clincal Medicine, Univ. of Tsukba, Tsukuba, Japan; 2Dept. of Nephrology, Hitachi General Hosp., Hitachi, Japan; 3Dept. MONDAY of Int. Medicine, Namegata District General Hosp., Tamatsukuri, Japan

M596 THE EFFECT OF OXIDATIVE STRESS ON CC- CHEMOKINES LEVELS IN HAEMODIALYZED PATIENTS Krystyna Pawlak,1 Dariusz Pawlak,2 Michal Mysliwiec.1 1Nephrology and Internal Medicine, Medical University, Bialystok, Poland; 2Pharmacodynamics, Medical University, Bialystok, Poland

M597 COMPARATIVE EVALUATION OF OXIDATIVE AND ANTIOXIDATIVE CAPACITY DURING HIGH-FLUX HAEMODIALYSIS USING TWO DIFFERENT MEMBRANES. RESULTS FROM A PROSPECTIVELY RANDOMISED STUDY Walter Samtleben,1,2 Christina Dengler,1 Friedrich Ebeling,2 Marc M.C. Heydenreich,2 Guenther F. Hillebrand.1,2 1Nephrology Department, Medical Clinic I, University Hospital Grosshadern, Muenchen, Bavaria, Germany; 2Kuratorium Dialysis Centre, Neuried / Muenchen, Bavaria, Germany

M598 CONTINUOUS MAINTENANCE IRON THERAPY IS RESPONSIBLE FOR A DECREASE IN SERUM TRANSFERRIN CONCENTRATION IN rHuEPO-TREATED DIALYSIS PATIENTS Daniela Bergamo, Manuel Burdese, Emanuela Maddalena, Giulio Podda, Sara Barbieri, Fabrizio Fop, Caterina Canavese. Chair of Nephrology, University of Turin, Turin, Italy

M599 OXIDATIVE STRESS IN PATIENTS ON HAEMODIALYSIS Anna Mrzljak,1 Mirjana Sabljar-Matovinovic,1 Suzana Borovic,4 Mladen Knotek,1 Sigmund Thune,2 Irena Jukic,3 Branimir Jaksic,1 Dinko Skegro,1 Morana Zivkovic,4 Franz Tatzber,5 Greta Pifat,4 Neven Zarkovic.4 1Dept. of Internal Medicine, Div. of Nephrology, "Merkur" Univ. Hosp., Zagreb, Croatia; 2"Hipokrat" Dialysis Center, Zagreb, Croatia; 3Croatian National Inst. of Transfusion Medicine, Zagreb, Croatia; 4Div. of Molecular Medicine, Rudjer Boskovic Inst., Zagreb, Croatia; 5Dr. Franz Tatzber KEG, Klosterneuburg, Austria

M600 THE EFFECT OF ACETATE-FREE-BIOFILTRATION ON OXIDATIVE STRESS ON DNA AND CARBONYL STRESS OF HUMAN BLOOD Takahiro Kuragano, Tsutomu Kuno, Chii Yamamoto, Yuji Nagura, Susumu Takahashi, Koichi Matsumoto, Katsuo Kanmatuse. 2nd Dept. of Internal Medicine, Nihon Univ. School of Medicine, Itabashi-Ku, Tokyo, Japan

M601 AUTONOMIC NEUROPATHY IS ASSOCIATED WITH OXIDATIVE STRESS IN NON-DIABETIC PATIENTS ON HEMODIALYSIS (HD) TREATMENT Serap Demir,1 Tülay Köken,2 Mustafa Serteser,2 Ebru Türkkan,1 Ersel Onrat,3 Ahmet Kahraman,2 Dayimi Kaya,3 Ataç Çelik,3 Güldane Çetinkaya,4 Çigdem Gökçe.1 1Departments of Medicine, Kocatepe University; 2Biochemistry; 3Cardiology; 4HD Centre, Afyon, Turkey TH MONDAY JUNE 9 POSTERS

M602 MUSCLE FIBRE COMPOSITION AND SIZE IN CHRONIC HAEMODIALYSIS PATIENTS Stig Molsted,1 Inge Eidemak,2 Jesper Andersen,3 Helle Sorensen,1 Adrian Harrison,4 Jens Kristensen.1 1Medical Orthopaedic and Rehabilitation, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; 2Nephrology P, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; 3Copenhagen Muscle Research Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; 4Institute of Anatomy & Physiology, The Royal Veterinary & Agricultural University, Copenhagen, Frederiksberg, Denmark

M603 IMPACT OF LIPID APHERESIS TREATMENT ON C-FOS, C-JUN, HSP70, AND EGR-1 GENE EXPRESSION IN WHITE BLOOD CELLS Volker Schettler,1 Katrin Zander,2 Ulrike Bonitz,2 Eberhard Wieland,2 Gerhard A. Muller.1 1Nephrology and Rheumatology, Georg-August University, Goettingen, Lower-Saxony, Germany; 2Clinical Chemistry, Georg- August University, Goettingen, Lower-Saxony, Germany POSTERS MONDAY JUNE 9TH

ESRD TREATMENT COMPARISONS

M604 HEMODYNAMIC STABILITY IN PREDILUTION HEMODIAFILTRATION (HDF) COMPARED WITH LOWFLUX HEMODIALYSIS (HD) AT TEMPERATURE CONTROLLED CONDITIONS - A BLINDED RANDOMIZED CONTROLLED TRIAL J.D. Jensen,1 N. Karamperis,1 E. Sloth.2 1Dept of Nephrology C, Skejby, Aarhus University Hospital, Aarhus, Denmark; 2Dept of Intensive Care, Skejby, Aarhus University Hospital, Aarhus, Denmark

M605 HEMODIAFILTRATION WITH ON-LINE REINFUSION (ON-LINE MONDAY HFR) INDUCES A MINOR LOSS OF ESSENTIAL AMINO ACIDS DURING HEMODIALYSIS TREATMENT Eftratios Fasianos,1 Antonio Saccheti,1 Giuseppe Cataldi,1 Giosafatte Pallotta,1 Pernina Angelini,1 Loredana Arnesano,1 Mario Nuzziello,1 Loretto Gesualdo.2 1Nephrology Unit, Hospital of Altamura, Altamura, Bari, Italy; 2Interuniversity Center of Research, University of Bari and Foggia, Bari, Italy

M606 PLASMA ENDOTHELIN-1 LEVELS DURING HAEMODIALYSIS AND HAEMODIAFILTRATION C.N. Balodimos,1 C.J. Petropoulou,1 P.G. Katsoris,2 B. Kapompasi,1 T.P. Danidi,1 O. Chionis,1 E.A. Karra,1 D.G. Triantafyllou,3 G.N. Triantafyllou.1 1Department of Nephrology, General Hospital of Pirgos, Pirgos, Greece; 2Department of Biology, University of Patras, Patras, Greece; 3Department of Epidemiology, Centre of Health Services Research, School of Medicine, University of Athens, Athens, Greece

M607 IMPACT OF HAEMODIALYSIS UND HAEMODIAFILTRATION ON SERUM LEVELS OF CYSTATIN C, BETA-2-MICROGOBULIN AND BETA-TRACE PROTEIN IN ESRD Thomas Gerhardt, Uwe Pöge, Hans-Ulrich Klehr, Tilman Sauerbruch, Rainer Peter Woitas. Dept. of Internal Medicine I, University Hospital, Bonn, Germany

M608 DECREASE OF SERUM PHOSPHATE WITH ON-LINE HAEMODIAFILTRATION Lajos Vaslaki,1 Lajos Major,2 Klara Berta,3 Andras Karatson,4 Mihay Misz,5 Ferenc Pethoe,6 Erzsebet Ladanyi,7 Bertalan Fodor,7 Hartmut Wieghold,8 Ralf Wojke,8 Adelheid Gauly,8 Jutta Passlick- Deetjen.8 1Dialysis Center, FMC, Sopron, Hungary; 2Dialysis Center, FMC, Esztergom, Hungary; 3Dialysis Center, FMC, Budapest, Hungary; 4Dialysis Center, FMC, Pecs, Hungary; 5Dialysis Center, FMC, Eger, Hungary; 6Dialysis Center, FMC, Salgotarjan, Hungary; 7Dialysis

M609 INCREASE IN VON WILLEBRAND FACTOR DURING HEMODIALYSIS WITH BIO-INCOMPATIBLE MEMBRANES SUGGESTS ENDOTHELIAL ACTIVATION Inge Wauters, Muriel Grooteman, Casper Schalkwijk, Piet ter Wee, Menso Nube. Department of Nephrology, Free University Medical Centre, Amsterdam, Netherlands

M610 DOES BIOCOMPATIBLE DIALYZER MEMBRANES ATTENUATE SYSTEMIC INFLAMMATION? Faikah Gueler,1 Carsten Schiborr,1 Wilfried Gwinner,1 Torsten Kirsch,1 Anette Fiebeler,2 Hermann Haller,1 Danilo Fliser.1 1Nephrology, Medical School Hannover, Berlin, Germany; 2Nephrology, Franz-Volhard-Clinic, Humboldt University, Berlin, Germany TH MONDAY JUNE 9 POSTERS

M611 POSSIBLE MARKERS FOR BIOCOMPATIBILITY OF HEMODIALYSIS MEMBRANES Petar Dejanov,1 Beti Dejanova,2 Momir Polenakovic,1 Aleksandar Sikole.1 1Dept. of Nephrology, Clinical Center, Skopje, Macedonia, The Former Yugoslav Republic of; 2Dept. of Physiology, Medical Faculty, Skopje, Macedonia, The Former Yugoslav Republic of Macedonia

M612 PROCALCITONIN IN HEMODIALYSED PATIENTS Dimitris Petras,1 Athanasia Tsiringa,2 Nektarios Karrefillakis,1 Clykeria Tsouka,1 Baitsa Karampasi,2 Caterine Petrochilou,2 Chrisa Kontou-Kastellanou,2 Ioannis Kakavas.1 1Nephrology Dept., General Hosp. “Hippokratio”Athens, Greece; 2Microbiology Dept., General Hosp. “Hippokratio”Athens, Greece

M613 C-REACTIVE PROTEIN (CRP) DURING HEMODIALYSIS ON CUPROPHAN, HEMOPHAN AND POLYSULPHONE MEMBRANE Nada Dimkovic,1 Jovan Popovic,1 Ljubica Djukanovic,2 Vladimir Ostric,2 Stevan Pljesa,3 Slobodan Curic,4 Jadranka Vodopivec,4 Svetislav Kostic,5 Momcilo Vukomanovic,5 Marina Lazarevic,6 Natasa Mitrovic.6 1Ctr Renal Diseases, Zvezdara Univ Hosp, Belgrade; 2Clinic Urol/ Nephrology, Clin Ct Serbia, Belgrade; 3CHC Zemun, Belgrade; 4Clin Ctr Novi Sad, Novi Sad; 5Clin Ctr Nis, Nis, 6Clin Ctr Kragujevac, Kragujevac, Yugoslavia

M614 COMPARATIVE STUDY OF THREE TYPES OF DIALYSIS MEMBRANES REGARDING THEIR EFFECT ON NATURAL INHIBITORS OF COAGULATION, D-DIMERS(DD) AND FIBRINOGEN(FIB) IN CHRONIC HEMODIALYSIS(HD) PATIENTS Efthemia Mourvati,1 Athanasia Agorasti,2 Apostolos Kyrgialanis,1 Aggelos Goutzouvelidis,1 Byron Asimakopoulos,3 Despina Konstantinidou,2 Hristos Hatzidimitriou.1 1Renal Unit, General Hospital, Xanthi, Thrace, Greece; 2Laboratory of Hematology, General Hospital, Xanthi, Thrace, Greece; 3Laboratory of Physiology, Faculty of Medicine, Democritus University, Alexandroupolis, Thrace, Greece

M615 PATIENT AND TREATMENT CHARACTERISTICS IN THE MPO STUDY: VALIDATION AGAINST THE DOPPS POPULATION F. Locatelli,1 F.K. Port,2 R.L. Pisoni,2 A. Martin-Malo,3 M. Papadimitriou,4 R. Vanholder,5 T. Hannedouche,6 S.H. Jacobson,7 C. Ronco,8 A. Loureiro,9 S. Czekalski,10 V. Wizemann,11 MPO Study Group. 1Ospedale Di Lecco, Lecco, Italy; 2URREA, Ann Arbor, MI, United States; 3Hospital Reina Sofia, Cordoba, Spain; 4Hippokration General Hospital, Thessaloniki, Greece; 5Universitair Ziekenhuis, Gent, Belgium; 6Hospices Civils, Strasbourg, France; 7Karolinska Hospital, Stockholm, Sweden; 8Ospedale S. Bortolo, Vicenza, Italy; 9Instituto Portugues De Oncologia, Porto, Portugal; 10Klinika Nefrologii, Posnan, Poland; 11Georg-Haas-Dialysezentrum, Giessen, Germany

M616 PATIENT AND TREATMENT PATTERNS AT START OF DIALYSIS: ANALYSIS OF THE EFFECT OF AGE A. Martin-Malo,1 S. Czekalski,2 Th. Hannedouche,3 S.H. Jacobson,4 A. Loureiro,5 M. Papadimitriou,6 C. Ronco,7 R. Vanholder,8 V. Wizemann,9 F. Locatelli,10 MPO Study Group. 1Dept. of Nephrology, Hospital Reina Sofia, Cordoba, Spain; 2Dept. of Nephrology, Klinika Nefrologii, Posnan, Poland; 3Dept. of Nephrology, Hospices Civils, Strasbourg, France; 4Dept. of Nephrology, Karolinska Hospital, Stockholm, Sweden; 5Dept. of Nephrology, Instituto Portugues De Oncologia, Porto, Portugal; 6Dept. of Nephrology, Hippokration General Hospital, Thessaloniki, Greece; 7Dept. of Nephrology, Ospedale S. Bortolo, Vicenza, Italy; 8Dept. of Nephrology, Universitair Ziekenhuis, Gent, Belgium; 9Georg-Haas- Dialysezentrum, Giessen, Germany; 10Dept. of Nephrology, Ospedale di Lecco, Lecco, Italy POSTERS MONDAY JUNE 9TH

M617 LEPTINE KINETICS AND CLEARANCE DURING MAINTENANCE HEMODIALYSIS: EFFECT OF HIGH FLUX MEMBRANES Anne Jolivot,1 François Combarnous,1 Ghislaine Geleen,2 Jane Bruton,3 Genevieve Jourdin,4 Maurice Laville,1 Denis Fouque.1 1Dept Nephrology, Hosp E.Herriot, Lyon, France; 2Environmental Physiology, Univ Claude Bernard Lyon1, Lyon, France; 3Asahi Medical, Tokyo, Japan; 4Hemotech, France

M618 IN VIVO COMPARISON OF TWO NEW HIGH-FLUX MEMBRANES IN HAEMODIALYSIS (HD) Dagmar Jaekel,1 Volker Kliem,1 Birgit Reinhardt,2 Nicole Sauer,2 Horst-Dieter Lemke,2 Detlef H. Krieter.3 1Nephrology, Nephrological Center Lower Saxony, Hann. Muenden, Germany; 2Membrana Research, Obernburg, Germany; 3Nephrology, University of Montpellier, Montpellier, France MONDAY

M619 DIFFERENCES IN THE PERMEABILITY OF HIGH-FLUX MEMBRANES FOR BACTERIAL PYROGENS Ralf Schindler, Friederike Christ-Kohlrausch, Ulrich Frei, Stanley Shaldon. Nephrology, Virchow Clinic, Berlin, Germany

M620 INDUCTION OF APOPTOSIS IN HUMAN NEUTROPHILS BY BIOCOMPATIBLE AND -INCOMPATIBLE MEMBRANES Kathrin Hochegger,1 Hendrik Koller,1 Gerhard J. Zlabinger,2 Karl Lhotta,1 Gert Mayer,1 Alexander R. Rosenkranz.1 1Department of Internal Medicine/Clinical Division of Nephrology, University Hospital Innsbruck, Innsbruck, Tirol, Austria; 2Institute of Immunology, University of Vienna, Vienna, Austria

M621 THE POSSIBLE EFFECT OF THE DIALYZER MEMBRANE ON OUTCOME OF ACUTE RENAL FAILURE PATIENTS Petar Kes,1 Dragan Ljutic,2 Nikolina Bašic-Jukic.1 1Department of Dialysis, Clinical Hospital Centre Zagreb, Zagreb, Croatia; 2Department of Medicine, Clinical Hospital Split, Split, Croatia

M622 EFFECTS IN A SIMULATED DIALYSIS CIRCUIT OF DIALYSIS SOLUTIONS WITH DIFFERENT CONCENTRATION OF ACETATE (BICARBONATE OR ACETATE-FREE SOLUTIONS) IN ASSOCIATION WITH MEMBRANES PROVIDED WITH DIFFERENT BIOCOMPATIBILITY (CUPROPHAN, AN69, AN69 ST) Alessandro Amore, Paola Cirina, Monica Chiesa, Alessandra Mollo, Stefania Turcato, Giovanni Conti, Rosanna Coppo. Nephrology Dialysis Transplantation, Regina Margherita Children’s Hospital, Torino, Italy

M623 MORTALITY IN HEMODIALYSIS AND PERITONEAL DIALYSIS IS DIFFERENT BECAUSE OF COMORBIDITIES Giovanni F.M. Strippoli,1 Mario Querques,2 Antonio Pappani,2 Carlo Manno.1 1Dept. of Emergency and Organ Transplantation, University of Bari, Italy; 2Dept. of Nephrology and Dialysis, OO.RR., Foggia, Italy

M624 EFFECT OF STARTING WITH HEMODIALYSIS COMPARED WITH PERITONEAL DIALYSIS IN PATIENTS NEW ON DIALYSIS TREATMENT: A RANDOMIZED CONTROLLED TRIAL Johanna C. Korevaar,1 Geert W. Feith,2 Friedo W. Dekker,3 Jeannette G. van Manen,1 Elisabeth W. Boeschoten,4 Patrick M. Bossuyt,1 Raymond T. Krediet.5 1Dept Clin Epidem & Biostat, AMC, Amsterdam; 2Dept Nephrology, Hosp Gelderse Vallei, Ede; 3Dept Clin Epidem, Leiden Univ Med Centre, Leiden; 4Dept Nephrology, Dianet-AMC, Amsterdam, Netherlands, 5Dept Nephrology, AMC, Amsterdam, Netherlands TH MONDAY JUNE 9 POSTERS

M625 CASPASE-3/8- DEPENDENT APOPTOSIS IS INCREASED IN UREMIA AND HEMODIALYSIS BUT NOT IN PERITONEAL DIALYSIS Vincent D’Intini,1 Valeria Bordoni,1 Elisabetta Galloni,1 Ciro Tetta,2 Nathan Levin,3 Claudio Ronco.1 1Dept Nephrol Dial Trasnplant, St Bortolo Hosp, Vicenza, Italy; 2Div Med, Fresenius Medical Care, Bad Homburg, Germany; 3Renal Research Institute, New York, United States

M626 A PROSPECTIVE COMPARISON OF QUALITY OF LIFE IN AN INCIDENT POPULATION OF PERITONEAL DIALYSIS AND HAEMODIALYSIS PATIENTS John Collins,1 Patricia Metcalf.2 1Renal Medicine, Auckland Hospital, Auckland, New Zealand; 2Division of Community Health, University of Auckland, Auckland, New Zealand

M627 MAYOR CHANGES OF MONOCYTE SURFACE ANTIGENS IN EARLY CHRONIC RENAL FAILURE ARE NOT OR ONLY PARTIALLY CORRECTED BY DIALYSIS TREATMENT OF UREMIA Juergen Scherberich. 2nd Med. Dept.(Nephrology and Dialysis), Hosp.M.-Harlaching of L.Maximilians Univ., Muenchen, Bavaria, Germany

M628 AGED PATIENTS WITH TYPE 2 DIABETES OR WITH CARDIOVASCULAR COMORBIDITY HAVE A BETTER SURVIVAL IN HEMODIALYSIS THAN IN PERITONEAL DIALYSIS Emmanuel Villar,1 Michel Labeeuw,1 Paul Vialtel,2 Francois Berthoux,3 Claire Pouteil-Noble.1 1Nephrology, Dialysis, Transplantation, Lyon Sud Univ. Hosp., Pierre-Benite, Rhone, France; 2Nephrology, Dialysis, Transplantation, Grenoble Univ. Hosp., La Tronche, Isere, France; 3Nephrology, Dialysis, Transplantation, Saint Etienne Univ. Hosp., Saint Priest en Jarrez, Loire, France

M629 NO INFLUENCE OF DIALYSIS MODALITY ON SURVIVAL IN PATIENTS WITHOUT TYPE 2 DIABETES AND WITHOUT CARDIOVASCULAR COMORBIDITY Emmanuel Villar,1 Michel Labeeuw,1 Paul Vialtel,2 Francois Berthoux,3 Claire Pouteil-Noble.1 1Nephrology, Lyon Sud Univ. Hosp., Pierre-Benite, Rhone, France; 2Nephrology, Grenoble Univ. Hosp., La Tronche, Isere, France; 3Nephrology, St Etienne Univ.Hosp., St Priest en Jarrez, Loire, France

M630 ANALYSIS OF RISK FACTORS FOR HOSPITALIZATION OF DIALYSIS PATIENTS D. Deren Oygar, Suheyla Apaydin, A. Serap Yalin, M. Riza Altiparmak, Kamil Serdengecti, Rezzan Ataman, Ekrem Erek. Internal Medicine Neprology, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey

M631 RENAL REPLACEMENT THERAPY IN DIABETICS: PERITONEAL VERSUS HEMO DIALYSIS – EXPERIENCE FROM BANGLADESH Masud Iqbal,1 N. Islam,2 M.Z. Kabir,1 M.A. Mansur,2 G.M. Nayeem,2 S. Islam,3 M.R. Alam,3 H.U. Rashid,3 H. Rahman.3 1Nephrology, National Institute of Kidney Diseases and Urology(NIKDU), Dhaka, Bangladesh; 2Nephrology, BIRDEM, Dhaka; 3Nephrology, BSM Medical University, Dhaka, Bangladesh

M632 THE CHOICE OF DIALYSIS MODALITY. ONE CENTRE EXPERIENCE Ioannis Kalevrosoglou, Karmen Tasiopoulou, Aliki Akritidou, Stylianos Vassiliou, Dimitrios Grekas, Eleftherios Giannoulis. 1st Medical Department,Division of Nephrology, AHEPA University Hospital, Thessaloniki, Greece POSTERS MONDAY JUNE 9TH

M633 ACCESS TO HAEMODIALYSIS TREATMENT: OPINIONS FROM NEPHROLOGISTS IN THE DIALYSIS OUTCOMES AND PRACTICE PATTERNS STUDY (DOPPS) Hugh Rayner,1 Roger Greenwood,2 Jennifer Bragg-Gresham,3 Ronald Pisoni,3 Vittorio Andreucci,4 Bernard Canaud,5 Friedrich Port,3 Kenneth Chen,7 Eric Young.6 1Dept. of Renal Medicine, Birmingham Heartlands Hospital, Birmingham, United Kingdom; 2Dept. of Renal Medicine, Lister Hospital, Stevenage, United Kingdom; 3DOPPS, URREA, Ann Arbor, MI, United States; 4Nephrology Dept., Universita Federico II, Naples, Ita

M634 START OF DIALYSIS H. Ledesma, J. Lercari, C. Lavorato, D. Ponce, M. Khoury, M. Der, N. Pissano, J. Perez Loredo. MONDAY Quality Program, Conferacion de Asociaciones de Dialisis de la Republica Argentina (CADRA), Buenos Aires, Argentina

M635 THE TIMING OF INITIATION OF DIALYSIS: A SURVEY OF 125 CHRONIC RENAL FAILURE (CRF) PATIENTS ON HEMODIALYSIS Li Yang, Mei Wang. Renal Division, Department of Medicine, First Hospital, Peking University, Beijing, China

M636 THE BORDEAUX STUDY OF INFLAMMATION IN CHRONIC HEMODIALYSIS PATIENTS (BICHE STUDY): CORRELATIONS BETWEEN MARKERS OF INFLAMMATION, PATIENTS CHARACTERISTICS, HEMODIALYSIS TECHNIQUE AND OUTCOME P. Chauveau,1 J.P. Bourdenx,2 D. Montaudon,3 M.C. Cazin, C. Lasseur,1 V. de Précigout,1 M. Normand,4 C. Level,1 P. Seniuta,5 C. Combe.1 1Nephrology, Centre Hospitalier Universitaire, Bordeaux; 2CTMR St-Augustin, Bordeaux; 3Biochemistry, Centre Hospitalier Universitaire, Bordeaux; 4Clinique St-Martin, Pessac; 5Clinique Bordeaux Nord, Bordeaux, France

M637 IS LONG HOUR HEMODIALYSIS PRACTICE STILL RELEVANT FOR NEPHROLOGISTS AND SATISFACTORY FOR THE PATIENTS? RECENT DATA FROM TASSIN Charles Chazot, Guillaume Jean, Jean Marc Hurot, Cyril Vo Van, Jean Claude Terrat, Thierry Vanel, Bernard Charra. Dialysis Unit, Centre de Rein Artificiel, Tassin, France TH MONDAY JUNE 9 POSTERS HEMODIALYSIS: UREMIC TOXINS

M638 INCREASED PLASMA S-NITROSOTHIOL CONCENTRATION PREDICTS CARDIAC OUTCOME IN HEMODIALYSIS (HD) PATIENTS: A PROSPECTIVE STUDY Ziad A. Massy,1,9 Christine Fumeron,2 Didier Borderie,3 Philippe Tuppin,4 Thao Nguyen-Khoa,1,5 Marie-Odile Benoit,6 Christian Jacquot,7 Claude Buisson,2 Tilman B. Drueke,1 Ohvanesse G. Ekindjian,3 Bernard Lacour,5 Marie-Christine Illiou.8 1INSERM U507, Necker Hospital; 2Dialysis Unit, AURA; 3Lab. Biochem. A, Cochin Hospital; 4Etablissement Francais des Greffes; 5Lab. Biochem. A, Necker Hospital; 6Lab. Biochem., HEGP; 7Div. Nephrol., HEGP; 8Cardiac Rehabilitation Center, Broussais Hospital, Paris; 9Div.Clin. Pharmacol. and Nephrol., Univ. Picardie and CHU- Amiens, Amiens, France

M639 EFFECTS OF THE UREMIC COMPOUND P-CRESOL ON ENDOTHELIAL CELLS IN VITRO Philippe Brunet, Laetitia Dou, Claire Cerini, Yvon Berland. INSERM EMI 0019 - Faculté de Pharmacie, Université de la Mediterranée, Marseille, France.

M640 UREMIA - EFFECTS OF CHRONIC RENAL FAILURE ON CONTRACTILE FUNCTION IN ISOLATED RAT MUSCLES A.P. Harrison,1 E.M. Bartels,2 A.H. Nielsen,3 I. Eidemak,4 S. Mølsted,5 S. Pierzynowski.6 1Anatomy & Physiology, KVL, Frederiksberg; 2Danish Library Science & Medicine, Copenhagen; 3Renal Ward B, Copenhagen Gen Hosp, KAS, Herlev; 4Renal Ward D, Frederiksborg Gen Hosp, Hillerød, Denmark; 5Animal Physiology, Lund Univ, Lund, Sweden.

M641 ENDOGENOUS FIBRINOGEN FRAGMENTS ISOLATED FROM UREMIC PLASMA INHIBIT THE EXPRESSION OF ACTIVATED PLATELET GPIIb-IIIa RECEPTORS T. Chirananthavat, U.R. Thekkedath, S.F. Mohammad, T. Masaki, J.K. Leypoldt, A.K. Cheung. 1Medicine and Pathology, University of Utah School of Medicine; 2VA Salt Lake City Health Care System, Salt Lake City, UT, USA

M642 IS UREMIC NEUROPATHY RELATED TO ADEQUACY AND DURATION OF HEMODIALYSIS THERAPY?A CROSS- SECTIONAL ANALYSIS OF NEUROPHYSIOLOGIC PARAMETERS IN LONG TERM HEMODIALYSIS PATIENTS Salwa Ibrahim,1 Hatem Samir,2 Hala Rashed,3 Dawlat Belal.1 1Department of Medicine, 2Department of Neurology, 3Department of Neurophysiology, Cairo University, Cairo, Egypt

M643 EVALUATION OF ELECTROMYOGRAPHIC FINDINGS IN SEVENTEEN UREMIC PATIENTS BEFORE AND AFTER HEMODIALYSIS Ali Moghtaderi,1 Hooshang Sanadgol,2 Shahryar Nafisi.3 1Neurol Dept, Khatam-Al-Anbia Hosp, Zahedan Univ Med Sciences, Zahedan, Iran; 2Dept Int Medicine, Nephrologist, Khatam-Al-Anbia Hosp, Zahedan Univ Med Sciences, Zahedan, Iran; 3Neurol Dept, Khatam-Dr. Shariati Hosp, Tehran Univ Med Sciences, Tehran, Iran

M644 THE INFLUENCE OF HEMODIALYSIS SESSION ON CARDIAC AUTONOMIC BALANCE Gwidon Polak,1 Pawel Strozecki,2 Grzegorz Grzesk,3 Romuald Przybyl,1 Jacek Manitius,2 Jacek Kubica.1 1Dept of Cardiology and Internal Medicine, The Ludwik Rydygier Medical University, Bydgoszcz, Poland; 2Dept of Nephrology and Internal Medicine, The Ludwik Rydygier Medical University, Bydgoszcz, Poland; 3Dept of Pharmacology and Therapeutics, The Ludwik Rydygier Medical University, Bydgoszcz, Poland POSTERS MONDAY JUNE 9TH

M645 NEUROGRAPHIC EVALUATION OF UREMIC POLYNEUROPATHY: CORRELATION WITH CLINICAL AND LABORATORY FINDINGS Saso Stojcev,1 Petre Risteski,1 Ljupco Trpenovski,2 Olivera Stojceva- Taneva.3 1Department of Neurology, Military Hospital, Skopje, Macedonia, The Former Yugoslav Republic of; 2Department of Nephrology, Military Hospital, Skopje, Macedonia, The Former Yugoslav Republic of; 3Department of Nephrology, Clinical Center, Medical Faculty, Skopje, Macedonia, The Former Yugoslav Republic of Macedonia

M646 IMPACT OF SOCIAL DEPRIVATION ON TREATMENT FOR END STAGE RENAL DISEASE Anu Trehan,1 Jean Winterbottom,1 Beverley Lane,1 Robert Foley,1 Michael Venning,1 Robert Coward,1 Alison MacLeod,2 Ram MONDAY Gokal.1 1SIRS Group, Manchester Royal Infirmary, United Kingdom; 2Renal Association Standards Subcommittee, United Kingdom

M647 THE ROLE OF INFLAMMATION IN UREMIC PRURITUS Martin Kimmel, Dominik Alscher, Robert Dunst, Ulrich Kuhlmann, Thomas Mettang. General Internal Medicine and Nephrology, Robert-Bosch Krankenhaus, Stuttgart, Germany

M648 ETIOLOGICAL SIGNIFICANCE OF MU- AND KAPPA-OPIOID SYSTEMS IN UREMIC PRURITUS OF PATIENTS UNDERGOING CHRONIC HEMODIALYSIS Shiro Maruyama,1 Hiroo Kumagai,2 Ichiei Narita,3 Kennji Takamori,4 Shinichi Nishi,5 Fumitake Gejyo.3 1Dept of Internal Medicine, Jyouetsu General Hospital, Jyouetsu, Niigata, Japan; 2Dept of Internal Medicine, Keio University School of Medicine, Tokyo, Japan; 3Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan; 4Dept of Dermatology, Juntendo University Urayasu Hospital, Urayasu, Chiba, Japan; 5Blood Purification Center, Niigata University Medical Hospital, Niigata, Japan

M649 PROTEOM ANALYIS OF DIALYSIS FLUIDS: TOWARDS IDENTIFICATION OF UREMIC TOXINS Thorsten Kaiser,1 Alena Herrmann,2 Sebastian Bartel,1 Igor Golovko,1 Marion Haubitz,2 Peer Koester,1 Ronald Krebs,1 Eva M. Weissinger,1 Stefan Wittke,1 Danilo Fliser,2 Hermann Haller,2 Harald Mischak.1,2 1Mosaiques Diagnostic, Mosaiques Diagnostics and Therapeutics AG, Hannover, Germany; 2Department of Nephrology, Medical School of Hannover, Hannover, Germany

M650 EFFECTS OF BIFIDOBACTERIA IN GASTRO-RESISTANT SEAMLESS CAPSULE ON SERUM LEVELS OF UREMIC TOXINS IN HEMODIALYSIS PATIENTS Kentaro Taki, Fumio Takayama, Mayumi Ikeda, Atsushi Enomoto, Isao Aoyama, Sakurako Nakamura, Toshimitsu Niwa. Department of Clinical Preventive Medicine, Nagoya University Hospital, Nagoya-city, Aichi, Japan

M651 REMOVAL DURING DIALYSIS OF URAEMIC PLASMA FACTOR(S) INDUCING AN INCREASED EXPOSURE OF PHOSPHATIDYLSERINE IN RED BLOOD CELLS: EFFECT OF TECHNIQUE AND MEMBRANE Vittorio Sirolli,1 Silvio Di Stante,1 Enzo Ballone,2 Walter Bisello,1 Mario Bonomini.1 1Institute of Nephrology, SS Annunziata University Hospital; 2Biostatistical Laboratory, University of Chieti, Chieti, Italy TH MONDAY JUNE 9 POSTERS

M652 DEVELOPMENT OF ORALLY ADMINISTERED MICROCAPSULES FOR REMOVAL OF UREMIC TOXINS Michael Lysaght, Jan Bruder, Jill O’Loughlin. Center for Biomedical Engineering, Brown University, Providence, RI, United States

M653 CLINICAL REPORT ON DIALYSIS-RELATED AMYLOIDOSIS Li Zhao, Ling Zhang, WeiJing Bian, FangTing Fu. Center of Nephrology, China-Japan Friendship Hospital, Beijing, China

M654 IMAGING OF DIALYSIS-RELATED AMYLOIDOSIS WITH 99mTc- BETA-2 MICROGLOBULIN Koco Cakalaroski, Daniela Ilic, Jelena Janevic-Ivanovska, Risto Grozdanovski, Ninoslav Ivanovski. Institute of Nuclear Medicine and Department of Nephrology, Clinical Centre,Vodnjanska 17, Skopje, Macedonia, The Former Yugoslav Republic of Macedonia

M655 RENAL REPLACEMENT THERAPY FOR END STAGE RENAL DISEASE RELATED TO AA AMYLOIDOSIS Ezzedine Abderrahim, Hafedh Hedri, Lamia Raies, Fatma Ben Moussa, Hayet Kaaroud, Rym Goucha, Taieb Ben Abdallah, Karim Zouaghi, Fethi El Younsi, Fethi Ben Hamida, Adel Kheder, Hedi Ben Maiz. Departement of Nephrology and Internal Medicine, Charles Nicolle Hospital, Tunis, Tunisia

M656 UREMIA - EFFECTS OF HAEMODIALYSIS ON MUSCLE FUNCTION IN 2ND DORSAL INTEROSSEOUS AND VASTUS LATERALIS M.H. Møller,1 I. Eidemak,1 S. Mølsted,1 A.H. Nielsen,2 A.P. Harrison.3 1Renal Ward D, Frederiksborg General Hospital, Hillerød, Denmark; 2Renal Ward B, Copenhagen General Hospital KAS, Herlev, Denmark; 3Anatomy & Physiology, The Royal Vet & Agric University KVL, Frederiksberg, Denmark

M657 CARDIOVASCULAR AGE IN ESRD PATIENTS Marko Jakic, Lada Zibar. for Dialysis, University Hospital Osijek, Osijek, Croatia POSTERS MONDAY JUNE 9TH

PD SOLUTIONS

M658 DIFFERENTIAL EXPRESSION OF RECEPTORS FOR ADVANCED GLYCATION ENDPRODUCTS (AGE) IN HUMAN PERITONEAL MESOTHELIAL CELLS (HPMC) TREATED WITH GLUCOSE DEGRADATION PRODUCTS (GDPs), CONVENTIONAL PD FLUID AND PD FLUID WITH LOW GPD LEVEL Kar Neng Lai,1 Anders Wieslander,2 Loretta Chan,1 Anita Tsang,1 Joseph Leung.1 1Medicine, Univ. of Hong Kong, Queen Mary Hosp., Hong Kong; 2Research, Gambro AB, Lund, Sweden

M659 IMPACT OF GLUCOSE DEGRADATION PRODUCTS (GDP) IN PD MONDAY FLUIDS ON THE PROCESS OF PERITONEAL TISSUE SCLEROSIS IN CAPD PATIENTS H.P. Bosselmann,1 U. Domroese,1 M. Aigner,2 H. Becker,3 V. Belwe,4 H.W. Birk,7 M. Bruns,5 M. Schroeder,6 T. Leimbach,8 B. Urbach,8 D. Schalon-Sahlfeld,9 E. Schillinger-Pokorny,10 P. Thon,11 S. Ansorge,12 M. Taeger,12 K.H. Neumann.1 1Nephrology, Otto-von-Guericke-Univ., Magdeburg, Germany; 2KfH, Ingolstadt, Germany; 3KfH, Berlin-Charlottenburg, Germany; 4KfH, Frankfurt, Germany; 5KfH, Hanau, Germany; 6KfH, Berlin- Reinickendorf, Germany; 7Justus-Liebig-Univ., Giessen, Germany; 8KfH, Berlin-Koepenick, Germany; 9KfH, Fulda, Germany; 10Dialysis Inst., Offenburg, Germany; 11KfH, Bad Hersfeld, Germany; 12IMTM, Magdeburg, Germany

M660 PERITONEAL DIALYSIS (PD) SOLUTION WITH REDUCED GLUCOSE DEGRADATION PRODUCT (GDP) CONTENT LOWERS SERUM CONCENTRATIONS OF ADVANCED GLYCATED ENDPRODUCTS (AGE) IN CHILDREN ON AUTOMATED PD Claus P. Schmitt, Dorothee von Heyl, Susi Haas, Otto Mehls, Franz Schaefer, Mid European Pediatric PD Study Group (MEPPS). Pediatric Nephrology Div., Univ. Children’s Hosp., Heidelberg, Germany

M661 TOXICITY OF INDIVIDUAL GLUCOSE DEGRADATION PRODUCTS IN PERITONEAL DIALYSIS FLUID Asahi Sakai. PD Dialysate Project, PD Technology Research Laboratory, Sakura- shi, Chiba-ken, Japan

M662 EFFECT OF GLYOXALASE AND GLUTATHIONE ON GLUCOSE DEGRADATION PRODUCT-RELATED TOXICITY OF DIALYSIS FLUIDS TOWARDS HUMAN PERITONEAL MESOTHELIAL CELLS Katarzyna Korybalska,1 Janusz Witowski,1,2 Justyna Wisniewska- Elnur,1 Andrzej Breborowicz,1 Achim Jörres.2 1Pathophysiology, University Medical School, Poznan, Poland; 2Nephrology and Medical Intensive Care, UK Charite, Virchow- Klinikum, Berlin, Germany

M663 ESTRUCTURAL CHARACTERIZATION OF PROTEIN OXIDATIVE DAMAGE IN PERITONEAL DIALYSIS FLUIDS AND EFFECTS OF DOUBLE-CHAMBER FLUIDS Teresa Donate,1 Rafael Garcia-Maset,1 Alba Herreros,1 Manel Portero-Otin,2 Reginal Pamplona,2 Maria Jose Bellmunt.2 1Nephrology Service, Fundacio Puigvert, Barcelona, Spain; 2Dept. Ciencies Mediques, Universitat de Lleida, Lleida, Spain

M664 INFLUENCE OF PERITONEAL DIALYSIS FLUID (PDF) ON THE DEPOSITION OF ADVANCED GLYCATION END-PRODUCT (AGE) IN THE PERITONEUM Chieko Higuchi, Yoko Tanihata, Hideki Nishimura, Takashi Naito, Tsutomu Sanaka. Dept. of Medicine, Tokyo Women’s Medical Univ. Daini Hospital, Tokyo, Japan TH MONDAY JUNE 9 POSTERS

M665 REDUCED FORMATION OF DNA-ADVANCED GLYCATION END- PRODUCTS (DNA-AGEs) BY DOUBLE-CHAMBERED, pH- NEUTRAL PERITONEAL DIALYSIS FLUIDS (PDF) DUE TO LOWER CONCENTRATIONS OF GLUCOSE DEGRADATION PRODUCTS (GDPs) Xiaohong Zhang,1 Matthias Frischmann,1 Marc Schneider,1 Thomas Schaub,2 Holger Schilling,2 Jutta Passlick-Deetjen,2 Monika Pischetsrieder.1 1Institute of Pharmacy and Food Chemistry, Universtity of Erlangen, Erlangen, Germany; 2Fresenius Medical Care, Fresenius Medical Care, Bad Homburg, Germany

M666 CLINICAL EXPERIENCE OF A PHYSIOLOGIC PERITONEAL DIALYSIS SOLUTION (PHYSIONEAL 40) IN AN APD POPULATION: A REPORT ON BEHALF OF THE PHYSIONEAL 40 APD RESEARCH GROUP Max Dratwa,1 Jean-Philippe Ryckelynck,2 Peter Rutherford.3 1Nephrologie-Dialyse, CHU Brugmann, Brussels, Belgium; 2Service de Néphrologie, CHU Clémenceau, Caen, France; 3Renal Unit, NE Wales NHS Trust, Wrexham, Clwyd, United Kingdom

M667 BIOCOMPATIBILITY OF IRON SUCROSE IN CONDITIONS OF PERITONEAL DIALYSIS Maciej Breborowicz,1 Alicja Polubinska,1 Paul Tam,2 George Wu,2 Andrzej Breborowicz.1 1Pathophysiology, Poznan Medical School, Poznan, Poland; 2Life Sciences, Toronto, ON, Canada

M668 ICODEXTRIN AND GLUCOSE TRANSPORT ACROSS PARIETAL PERITONEUM: THE IN VITRO STUDIES Beata Szary, Krystyna Czyzewska, Teresa Grzelak. Chemistry and Clinical Biochemistry, University of Medical Sciences, Poznan, Poland

M669 INFLUENCE OF GLUCOSE EXPOSURE AND ICODEXTRIN USE ON LONGITUDINAL CHANGES IN MEMBRANE FUNCTION IN ANURIC APD PATIENTS Simon J. Davies,1 Edwina A. Brown,2 Peter Rutherford,3 Werner Riegel,4 Niels E Frandsen,5 Merce Borras,6 Frederique Meeus,7 Anabella S. Rodrigues,8 Monique Van Bree,9 Jose C. Divino Filho.9,10 1Renal, North Staffordshire Hospital, Stoke-on-Trent, United Kingdom; 2Renal, Imperial College, Charing Cross Hospital, London, United Kingdom; 3Renal, Wrexham Maelor Hospital, Clwyd, United Kingdom; 4Klinikum Darmstadt, Darmstadt, Germany; 5Central Hospital Esbjerg, Esbjerg, Denmark; 6Hospital Arnau de Vilanova, Lerida, Spain; 7Centre Hospitalier Louise Michel Evry, Evry, France; 8Hospital Geral Santo Antonio, Porto, Portugal; 9Renal, Baxter Healthcare, Brussels, Belgium; 10Department of Renal Medicine, Baxter Novum Huddinge University,Hospital Karolinska Institutet, Huddinge, Sweden;

M670 BIOCOMPATIBILITY OF A NEW PERITONEAL DIALYSIS SOLUTION CONTAINING TAURINE Hideki Nishimura, Osamu Ikehara, Takashi Naito, Chieko Higuchi, Tsutomu Sanaka. Internal Medicine, Tokyo Women’s Medical University Daini Hospital, Tokyo, Japan

M671 CHRONIC PERITONEAL EXPOSURE TO A COMBINATION OF FILTER STERILIZATION, OSMOTIC AGENTS AND PYRUVATE Roos van Westrhenen,1 Johan Hiralall,2 Najat Hajji,2 Cindy Dragt,2 Raymond Krediet.1 1Nephrology, Academic Medical Center, Amsterdam, Netherlands; 2Clinical Chemistry, Academic Medical Center, Amsterdam, Netherlands POSTERS MONDAY JUNE 9TH

M672 BIOCOMPATIBILITY PATTERN OF A NEUTRAL BICARBONATE/ LACTATE BUFFERED PERITONEAL DIALYSIS SOLUTION IN CHRONIC APD PATIENTS - A PROSPECTIVE; RANDOMIZED; CROSS OVER STUDY Andreas Fusshoeller, Markus Plail, Gabi Ausobski, Bernd Grabensee, Joerg Plum. Nephrology, Heinrich Heine University, Duesseldorf, Germany

M673 THE EFFECTS OF A HIGH- VERSUS A LOW-GLUCOSE REGIME ON CELL RECRUITMENT AND BIOMARKERS OF CAPD PATIENTS. A MULTI-CENTER, PROSPECTIVE CROSS-OVER STUDY Angelique G.A. Welten,1 Caatje le Poole,3 Pieter M. ter Wee,2 Frans J. van Ittersum,2 Robert J.H. Beelen,1 Jacob van den Born.1 1Molecular Cell Biology, VU University Medical Center, Amsterdam, MONDAY Netherlands; 2Nephrology, VU University Medical Center, Amsterdam, Netherlands; 3Internal Medicine, RKZ, The Hague, Netherlands

M674 ACUTE EFFECT OF AMINO ACID PERITONEAL DIALYSIS SOLUTION ON VASCULAR FUNCTION Andreas Vychytil,1 Manuela Foedinger,2 Johannes Pleiner,3 Marcus Muellner,4 Peter Konner,1 Sonja Skoupy,2 Claudia Roehrer,2 Michael Wolzt,3 Gere Sunder-Plassmann.1 1Department of Medicine III, Division of Nephrology and Dialysis, University of Vienna, Vienna, Austria; 2Institute of Medical and Chemical Laboratory Diagnostics, University of Vienna, Vienna, Austria; 3Department of Clinical Pharmacology, University of Vienna, Vienna, Austria; 4Department of Emergency Medicine, University of Vienna, Vienna, Austria

M675 PERITONEAL TRANSPORT OF AMINO ACIDS (AA) DURING CAPD WITH AMINO ACID-BASED SOLUTION Anna Olszowska,1 Jacek Waniewski,2 Andrzej Werynski,2 Bjorn Anderstam,3 Bengt Lindholm,3 Zofia Wankowicz.1 1Department of Nephrology, Military Institute of Medicine, Warsaw, Poland; 2Institute of Biocybernetics and Biomedical Engineering, Warsaw, Poland; 3Division of Baxter Novum, Karolinska Institutet, Stockholm, Sweden

M676 VASCULAR ALTERATIONS AFTER LONG-TERM PERITONEAL EXPOSURE TO AN AMINO ACID-BASED PDF AND A CONVENTIONAL PDF WITH OR WITHOUT AMINOGUANIDINE IN THE RAT Mammad Zareie,1 Piet M. ter Wee,2 Liesbeth H.P. Hekking,1 Eelco D. Keuning,1 Robert H.J. Beelen,1 Jacob van den Born.1 1Molecular Cell Biology, VU University Medical Center, Amsterdam, Netherlands; 2Nephroloyg, VU University Medical Center, Amsterdam, Netherlands

M677 PERITONEAL TRANSPORT WITH 3 DIFFERENT PERITONEAL SOLUTIONS Jesús Montenegro, Ramón Saracho, Isabel Martínez, Rosa I. Muñoz, Julián Ocharan. Nephrology, Hospital de Galdakao, Bilbao, Vizcaya, Spain TH MONDAY JUNE 9 POSTERS PD: PERITONITIS

M678 STAPHYLOCOCCUS AUREUS PERITONITIS IN NEW ZEALAND IN THE YEARS 1996-2000 John Collins, Bobby Charlton. Renal Medicine, Auckland Hospital, Auckland, New Zealand

M679 DIAGNOSTIC USEFULNESS OF 23S rRNA AMPLIFICATION AND DIRECT SEQUENCING IN CAPD PATIENTS Ho Yung Lee,1 So Rae Choi,1 Beom Seok Kim,1 Soo Young Yoon,1 Kyung Hee Chang,2 Hyung Cheon Park,1 Shin Wook Kang,1 Kyu Hun Choi,1 Jun Myung Kim,2 Seong Kyu Ha,1 Dae Suk Han.1 1Dept. of Internal Medicine, The Inst. of Kidney Disease, College of Medicine,Yonsei Univ., Seoul, Republic of Korea; 2Dept. of Internal Medicine, The Inst. of Infectious Disease, College of Medicine, Yonsei Univ., Seoul, Republic of Korea

M680 PERITONEAL DIALYSIS PERFORMANCE AND INCIDENCE OF PERITONITIS Marina Avramovic, Radmila Velickovic, Vladisav Stefanovic. Department for Peritoneal Dialysis, Institute of Nephrology and Hemodialysis, Nis, Serbia, Yugoslavia

M681 ASSESSMENT OF HMPAO-99MTC-LEUKOCYTE LABELED SCANNING IN CONTINUOUS AMBULATORY PERITONEAL DIALYSIS (CAPD) PATIENTS Miguel De la Torre,1 Ana Garcia,2 Roberto Alcazar,1 Guadalupe Caparros,1 Sonia Rodado,2 Victor Manuel Poblete,2 Dolores Sanchez de la Nieta,1 Josina De Santiago,1 Javier Nieto,1 Isabel Ferreras,1 Angel Soriano.2 1Nephrology, Hospital Alarcos, Ciudad Real, Spain; 2Nuclear Medicine, Hospital Alarcos, Ciudad Real, Spain

M682 OUTCOME OF RECURRENT PERITONITIS IN CHRONIC PERITONEAL DIALYSIS (CPD) PATIENTS Uma Sekar, Padma Gopalakrishnan, Milly Mathew, Abraham Georgi, Soundarajan Periyasami. Microbiology & Nephrology, Sri Ramachandra Medical College & Research Institute, Chennai, Tamil Nadu, India

M683 A NEW MICROBIOLOGICAL TREND IN PERITONEAL DIALYSIS- RELATED PERITONITIS? Stefano Maffei, Roberta Fenoglio, Alfonso Pacitti, Fabrizio Fop, Alessandra Messuerotti, Giuseppe Piccoli. Chair of Nephrology, University of Turin, Turin, Italy

M684 SERIAL CHANGES OF SERUM LEPTIN AND INFLAMMATORY MARKERS DURING AND AFTER ACUTE PERITONITIS IN CAPD PATIENTS Dae Suk Han, Joo Seong Kim, So Rae Choi, Soo Young Yoon, Hyung Cheon Park, Shin Wook Kang, Kyu Hun Choi, Seong Kyu Ha, Ho Yung Lee. Department of Internal Medicine, The Institute of Kidney Disease, College of Medicine, Yonsei University, Seoul, Republic of Korea

M685 LONGITUDINAL TRENDS IN ADULT PERITONEAL DIALYSIS- RELATED PERITONITIS: A 23 YEAR EXPERIENCE AT MONASH MEDICAL CENTRE Wen Liu,1 Despina Kotsanas,2 Tony Korman,2 Francine Lynn,1 Amy Obad,1 Robert Atkins,1 Fiona Brown.1 1Nephrology, Monash Medical Centre, Clayton, Victoria, Australia; 2Infectious Diseases, Monash Medical Centre, Clayton, Victoria, Australia POSTERS MONDAY JUNE 9TH

M686 PERITONITIS FREQUENCY AND PERITONEAL DIALYSIS ADEQUACY Marko Jakic, Lada Zibar. for Dialysis, University Hospital Osijek, Osijek, Croatia

M687 BIOFILMS OF TENCKHOFF CATHETERS IN CAPD PATIENTS Takeyuki Hiramtsu, Shinji Furuta, Takayuki Yamada, Hironobu Kakuta. Internal Medicine, Aihoku Hospital, Konan, Aichi-Prefecture, Japan

M688 DOSE- AND TIME-DEPENDENT INCREASE OF INFLAMMATORY MEDIATORS AND VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) IN RESPONSE TO LIPOPOLYSACCHARIDE INDUCED ACUTE PERITONITIS IN RATS Krzysztof Pawlaczyk,1,2 Malgorzata Kuzlan-Pawlaczyk,1 Justyna Wisniewska-Elnur,1 Stanislaw Czekalski,1 Bengt Lindholm,2 MONDAY Andrzej Breborowicz.1 1Department of Pathophysiology and Nephrology, University of Medical Sciences in Poznan, Poznan, Poland; 2Divisions of Baxter Novum and Renal Medicine, Karolinska Institutet, Stockholm, Sweden

M689 THE EFFICACY OF IRBESERTAN AND SPIRONOLACTON IN PREVENTING PERITONEAL FIBROSIS IN RATS Rifki Ersoy,1 Ali Celik,1 Osman Yilmaz,2 Sulen Sarioglu,3 Banu Sis,3 Pinar Akan,4 Tugba Atay,5 Dilek Cimrin,6 Camsari Taner.1 1Nephrology, Dokuz Eylul Univ. Medical School, Izmir, Turkey; 2Animal Lab., Dokuz Eylul Univ. Medical School, Izmir, Turkey; 3Pathology, Dokuz Eylul Univ. Medical School, Izmir, Turkey; 4Biochemistry, Dokuz Eylul Univ. Medical School, Izmir, Turkey; 5Microbiology, Dokuz Eylul Univ. Medical School, Izmir, Turkey; 6Central Lab., Dokuz Eylul Univ. Medical School, Izmir, Turkey

M690 INOCULATION OF PERITONEAL DIALYSATE INTO BLOOD CULTURE BOTTLES INCREASES CULTURE RATES COMPARED TO CONVENTIONAL METHOD IN PATIENTS WITH PERITONITIS DURING INTERMITTENT PERITONEAL DIALYSIS Muhibur Rahman, Nizamuddin Chowdhury, Shamim Ahmed. Nephrology, Dhaka Medical College, Dhaka, Bangladesh

M691 PATHOGENESIS OF STAPH AUREUS EXIT SITE INFECTION IN A RABBIT MODEL OF PERITONEAL DIALYSIS Mrinal K. Dasgupta, Marlene Larabie, Patrick Nation. Medicine, University of Alberta, Edmonton, Alberta, Canada

M692 RATE OF INFECTION OF THE EXIT SITE AND CATHETER SURVIVAL IN PERITONEAL DIALYSIS PATIENTS UNDER TWO EXIT SITE CARE PROCEDURES: IODINE-POVIDONE OR HOME- MADE SALINE HYPERTONIC SOLUTION Caparros Guadalupe,1 De Santiago Josina,1 De La Torre Miguel,1 Alcazar Roberto,1 Sanchez de la Nieta Dolores,1 Aguilera Dolores,2 Ferreras Isabel.1 1Nephrology, Hospital Alarcos, Ciudad Real, Spain; 2Microbiology, Hospital Alarcos, Ciudad Real, Spain

M693 SPECIFIC CHARACTERISTICS OF PERITONEAL LEUKOCYTE POPULATIONS DURING STERILE PERITONITIS ASSOCIATED WITH ICODEXTRIN CAPD FLUIDS Griet Glorieux, Norbert Lameire, Wim Van Biesen, Clement Dequidt, Raymond Vanholder. Internal Medicine, Renal Division, Ghent University Hospital, Gent, Belgium

M694 STERILE PERITONITIS SECONDARY TO ICODEXTRIN: IMMUNOHISTOPATHOLOGICAL DESCRIPTION IN 3 PATIENTS Eric Goffin,1 Gaelle Gillerot,1 Jean-Pierre Cosyns,2 Olivier Devuyst.1 1Nephrology, Cliniques Universitaires St Luc, Brussels, Belgium; 2Pathology, Cliniques Universitaires St Luc, Brussels, Belgium TH MONDAY JUNE 9 POSTERS TRANSPLANTATION: BASIC, EXPERIMENTAL

M695 DONOR BONEMARROW DERIVED STEM CELL INFUSION IN THYMUS AND PERIPHERY: AN INTEGRATED APPROACH TO ACHIEVE TOLERANCE IN CADAVER RENAL ALLOGRAFT RECIPIENT Divyesh Viroja, H.L. Trivedi, Pravina Shah, Veena Shah, Aruna Vaniker. Nephrology, IKDRC, Ahmedabad, Gujarat, India

M696 INTRACELLULAR CYTOKINE RESPONSE TO IMMUNOSUPPRESSIVE AGENTS IN PATIENTS WITH END STAGE RENAL FAILURE AWAITING TRANSPLANTATION Aurelia Zamauskaite,1 Peter Amlot,2 Andrew Davenport,1 Stephen Powis.1 1Centre for Nephrology, Royal Free & University College Medical School, London, United Kingdom; 2Department of Immunology, Royal Free & University College Medical School, London, United Kingdom

M697 EXPRESSION OF THE GRANZYME B INHIBITOR PI-9 IN HUMAN RENAL ALLOGRAFTS EXPLAINS STABLE RENAL FUNCTION IN SPITE OF CYTOTOXIC INFILTRATES Ajda T. Rowshani,1,2 Sandrine Florquin,3 Frederike Bemelman,1 Frank N.J. van Diepen,4 Angela M. Wolbink,5 J. Alain Kummer,6 C. Erik Hack,5,7 Ineke J.M. ten Berge.1,2 1Renal Transpl Unit, Dept Int Med, 2Div Clin Immunology and Rheumat, Dept Int Med, 3Dept Pathology, 4Lab Exp Immunology, AMC, Amsterdam; 5Dept Immunopathology, Sanquin Research CLB, 6Dept Pathology, 7Dept Clin Chemistry, VU Med Ctr, Amsterdam, Netherlands

M698 SELECTIVE INHIBITION OF JUN N-TERMINAL KINASE (JNK) IN ALLOREACTIVE HUMAN T CELLS IS PRIMARILY IMMUNOSUPPRESSIVE, BUT ENHANCES ACTIVATION- INDUCED CELL DEATH IN CONJUNCTION WITH mTOR TARGETING Marcus D. Säemann,1 Maddalena Soncini,2 Maximilian Zeyda,3 Gerhard J. Zlabinger,4 Walter Knapp,4 Walter H. Hörl,1 Ornella Parolini.2 1Department of Internal Medicine III, Division of Nephrology and Dialysis, University of Vienna, Vienna, Austria; 2Centro Ricerca Parco Scientifico, Ospedale Poliambulanza, Brescia, Italy; 3Department of Internal Medicine III, Division of Endocrinology and Metabolism, University of Vienna, Vienna, Austria; 4Institute of Immunology, University of Vienna, Vienna, Austria

M699 DELIVERY OF NFkB DECOY OLIGONUCLEOTIDES USING ULTRASOUND WITH MICROBUBBLES INTO TRANSPLANTED RAT KIDNEY Naruya Tomita,1 Haruhito Azuma,2 Hiromi Koike,3 Yoshiaki Taniyama,1 Katsuro Tachibana,4 Toshio Ogihara,1 Ryuichi Morishita.3 1Geriatric Medicine, Osaka University Graduate School of Medicine, Yamada-oka, Suita, Osaka, Japan; 2Urology, Osaka Medical College, Daigakucho, Takatsuki, Osaka, Japan; 3Clinical Gene Therapy, Osaka University Graduate School of Medicine, Yamada-oka, Suita, Osaka, Japan; 4Anatomy, Fukuoka University School of Medicine, Nanakuma, Jonan-ku, Fukuoka, Fukuoka, Japan POSTERS MONDAY JUNE 9TH

M700 DEVELOPMENT OF A NOVEL GENE TRANSFER METHOD ITNO RAT KIDNEY MEDIATED BY ULTRASOUND WITH MICROBUBBLES Naruya Tomita,1 Haruhito Azuma,2 Hiromi Koike,3 Yoshiaki Taniyama,1 Katsuro Tachibana,4 Toshio Ogihara,1 Ryuichi Morishita.2 1Geriatric Medicine, Osaka University Graduate School of Medicine, Yamada-oka, Suita, Osaka, Japan; 2Urology, Osaka Medical College, Daigakucho, Takatsuki, Osaka, Japan; 3Clinical Gene Therapy, Osaka University Graduate School of Medicine, Yamada-oka Suita, Osaka, Japan; 4Anatomy, Fukuoka University School of Medicine, Nanakuma, Jonan-ku, Fukuoka, Fukuoka, Japan

M701 MONITORING OF NFAT REGULATED GENE EXPRESSION THE PERIPHERAL BLOOD OF KIDNEY- AND LIVER ALLOGRAFT MONDAY RECIPIENTS – A NEW PERSPECTIVE OF INDIVIDUALIZED IMMUNOSUPPRESSION Thomas Giese,1 Peter Schemmer,2 Waldemar Uhl,2 Peter Sauer,3 Markus Buchler,2 Stefan Meuer,1 Martin Zeier.3 1Department of Immunology, University of Heidelberg, Heidelberg, Germany; 2Department of Surgery, University of Heidelberg, Heidelberg, Germany; 3Department of Internal Medicine, University of Heidelberg, Heidelberg, Germany

M702 EPITHELIAL CHIMERISM IS AN EARLY AND PERSISTENT EVENT AFTER RENAL TRANSPLANTATION Michael Mengel,1 Danny Jonigk,1 Magali Marwedel,1 Wolfram Kleeberger,1 Wilfried Gwinner,2 Hermann Haller,2 Hans Kreipe.1 1Institut fuer Pathologie, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, Hannover, Germany; 2Abteilung fuer Nephrologie, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, Hannover, Germany

M703 ANTI- HLA ANTIBODIES PRODUCTION AND NITRIC OXIDE LEVEL IN THE SERUM AND URINE OF POST TRANSPLANT PATIENTS IN RELATION TO GRAFT FUNCTION AND SURVIVAL Hayam El Aggan,1 Amal Ketat,2 Sherif Zaki,1 Mohamed Salam.1 1Internal Medicine (Nephrology Unit), Faculty of Medicine,University of Alexandria, Alexandria, Egypt; 2Medical Biochemistry, Faculty of Medicine,University of Alexandria, Alexandria, Egypt

M704 INTERFERON-ALPHA IS A POWERFUL PREDICTOR OF ACUTE REJECTION IN KIDNEY TRANSPLANTS Jose Gerardo Oliveira,1 Paula Xavier,2 Susana Sampaio,1 Isabel Tavares,1 Manuel Pestana.1 1Nephrology, Faculty Medicine - Hospital S Joao, Porto, Portugal; 2Tissue Typing, Porto, Portugal

M705 NATURAL KILLER CELL ACTIVITY AFTER HUMAN RENAL TRANSPLANTATION IN RELATION TO KIR AND HLA MISMATCH Maria Luisa Vampa,1 Paul Norman,2 Lisa Burnapp,1 Robert Vaughan,2 Steven H. Sacks,1 Wilson Wong.1 1Nephrology and Transplantation, Guy’s Hospital, London, United Kingdom; 2Tissue Typing Laboratories, Guy’s Hospital, London, United Kingdom

M706 EFFECTS OF EXOGENOUS OR INTRINSIC HEME OXYGENASE-1 (HO-1) ON APOPTOSIS, CASPASE-3 EXPRESSION AND DIFFERENTIATION OF MONOCYTES: IMPLICATIONS FOR ACUTE REJECTION OUTCOME Detlef Lang,1 Stefan Reuter,1 Tanja Latifi,1 Gert Gabriels,1 Christian August,2 Stefan Heidenreich.1 1Medical Department D, UKM, Münster, NRW, Germany; 2Gerhard- Domagk Institute of Pathology, UKM, Münster, NRW, Germany TH MONDAY JUNE 9 POSTERS

M707 CHANGES OF THE URETER MICROCIRCULATION PATTERNS DURING NEOIMPLANTATION TECHNIQUES IN ANIMAL MODEL Istvan Csizy,1 Istvan Furka,2 Tamas Cserny,1 Tamas Jozsa,1 Csaba Olah,1 Katalin Petho,2 Norbert Nemeth,2 Iren Miko.2 1Pediatrics, University of Debrecen, Debrecen, Hungary; 2Surgery, University of Debrecen, Debrecen, Hungary

M708 MAP KINASE SIGNALLING AFTER RENAL TRANSPLANTATION AND REJECTION IN RATS Gert Gabriels,1 Hartmut Halfter,2 Rita Schroeter,1 Heike Stegemann,1 Jochen Hirsch,1 Eberhard Schlatter.1 1Medizinische Klinik und Poliklinik D, Universitaetsklinikum Muenster, Muenster, Germany; 2Klinik und Poliklinik fuer Neurologie, Universitaetsklinikum Muenster, Muenster, Germany

M709 COMPARISON OF GENE EXPRESSION PROFILES BETWEEN SYNGENEIC AND ALLOGENEIC TRANSPLANTS Thomas Mueller,1 Yurong Liang,1 James Lederer,2 David Perkins.1 1Medicine, Renal Division, Brigham and Women’s Hospital, HMS, Boston, MA, United States; 2Surgery, Immunology, Brigham and Women’s Hospital, HMS, Boston, MA, United States

M710 ADOPTIVE TRANSFER OF ALLOSPECIFIC Th2 CELLS RESULTS IN TOLERANCE AFTER FULLY ALLOGENEIC KIDNEY TRANSPLANTATION AND INVOLVES SPECIFIC EXPRESSION OF T CELL RELATED ANTIGENS Martin Gasser,1 Martin R. Grimm,1 Michael W. Grimm,1 Andrea Trumpfheller,1 Sabine Mueller,1 Wayne W. Hancock,2 Anil Chandraker,3 Mohamed H. Sayegh,3 Ana Maria Waaga-Gasser.1 1Dept. of Surgery, University of Wuerzburg, Wuerzburg, Germany; 2Dept. of Pathology, Children’s Hospital, Philadelphia, PA, USA; 3Lab. of Immunogenetics and Transplantation, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

M711 DELETION OF PROTEIN KINASE C EPSILON IN KIDNEY TRANSPLANTS IMPROVES ALLOGENIC TRANSPLANT SURVIVAL Song Rong,1 Wen Zheng,1 Joon-Keun Park,1 Marlies Elger,1 Faikah Gueler,1 Michael Leitges,2 Hermann Haller.1 1Nephrology, Medical School Hannover, Berlin, Germany; 2Experimental Endocrinology, Max Planck Institut, Hannover, Germany

M712 CLASS II MHC SPECIFIC ALLOPEPTIDES MODULATE THE IMMUNE RESPONSE AFTER EXPERIMENTAL KIDNEY AND SMALL BOWEL TRANSPLANTATION VIA THE INDIRECT PATHWAY OF ALLORECOGNITION Martin Gasser, Miriam S. Lenhard, Christoph Otto, Detlef Meyer, Wolfgang Timmermann, Arnulf Thiede, Karin Ulrichs, Ana Maria Waaga-Gasser. Dept. of Surgery, University of Wuerzburg, Wuerzburg, Germany

M713 EVIDENCE FOR THE EARLY INVOLVEMENT OF INTERLEUKIN 17 IN HUMAN AND EXPERIMENTAL RENAL ALLOGRAFT REJECTION Ching-Yuang Lin. Dept. of Pediatrics, Children Hospital, Changhua Christian Hospital, Changhua, Taiwan POSTERS MONDAY JUNE 9TH

M714 EXPRESSION OF SILENCER OF DEATH DOMAIN AND DEATH- RECEPTOR-3 IN NORMAL HUMAN KIDNEY AND IN REJECTING RENAL TRANSPLANTS Rafia S. Al-Lamki,1 Jun Wang,1 Jeetendra R. Rathod,1 Sathia Thiru,2 Nicholas R. Pritchard,1 Andrew J. Bradley,3 Jordan S. Pober,4 John R Bradley.1 1Dept of Medicine, Univ. of Cambridge, Addenbrooke’s Hosp., Cambridge, Cambridgeshire, UK; 2Dept. of Pathology, Univ. of Cambridge, Addenbrooke’s Hosp., Cambridge, Cambridgeshire, UK; 3Dept. of Surgery, Univ.of Cambridge, Addenbrooke’s Hosp., Cambridge, Cambridgeshire, UK; 4The Boyer Center for Molecular Medicine, Yale Univ. School of Medicine, New Haven, CT, USA

M715 EVIDENCE FOR INDUCTION OF EPITHELIAL CELL SENESCENCE IN ACUTE REJECTION MONDAY Bernhard M.W. Schmidt, Oki Takeuchi, Joan Urmson, Philip F. Halloran, Anette Melk. Division of Nephrology and Immunology, University of Alberta, Edmonton, Alberta, Canada

M716 INTERFERON-INDUCIBLE PROTEIN-10 (CXCL10/IP-10) AND ITS RECEPTOR CXCR3 ARE CANDIDATE TARGETS FOR BLOCKING ALLOGRAFT REJECTION IN THE CLINICAL SETTING Ravi Tatapudi,1 Thangamani Muthukumar,1 Elizabeth Losardo,1 Nagashree Seetharamu,1 Darshana Dadhania,1 Ruchuang Ding,1 Baogui Li,1 Vijay K. Sharma,1 Surya V. Seshan,2 Manikkam Suthanthiran.1 1Division of Nephrology, Dept of Medicine, Weill Medical College of Cornell Univ., New York, NY, USA; 2Dept of Pathology, Weill Medical College of Cornell Univ., New York, NY, USA

M717 UP-REGULATION OF CA2+ ACTIVATED K+ CHANNELS IN T- LYMPHOCYTES DURING ACUTE RENAL ALLOGRAFT REJECTION Susanne Brakemeier, Doris Kaempfe, Ines Eichler, Ivica Grgic, Ralf Koehler, Joachim Hoyer. Nephrology, Univ.-Medical Center Benjamin Center, Berlin, Germany

M718 ESTIMATION OF SERUM AND URINARY TRANSFORMING GROWTH FACTOR-BETA1(TGF-b1) AND PLATELET DERIVED GROWTH FACTOR(PDGF) IN RENAL ALLOGRAFT RECIPIENTS Salwa Ibrahim,1 Gamal Saadi,1 Adalat Hegazi,1 Hala El-Gendy,1 Mervat Al-Ansary.2 1Department of Medicine, 2Department of Clinical Pathology, Cairo University, Cairo, Egypt

M719 DIFFERENTIAL EFFECTS OF GLYCOSAMINOGLYCANS ON RENAL INFLAMMATION DURING ACUTE AND CHRONIC RENAL ALLOGRAFT REJECTION AND ISOLATED ISCHEMIA- REPERFUSION INJURY IN RATS Claude Braun,1 Astrid Mueller-Falcke,1 Benito Yard,1 Walter Back,2 Dieter Herr,3 Fokko van der Woude.1 1Fifth Department of Medicine (Nephrology), University Hospital Mannheim, Mannheim, Germany; 2Institute of Pathology, University Hospital Mannheim, Mannheim, Germany; 3Abbott GmbH, Ludwigshafen, Germany

M720 DIFFERENTIATION OF REJECTION AND CYCLOSPORINE TOXICITY IN PATIENTS WITH KIDNEY TRANSPLANTATION: AN IMMUNOFLUORESCENCE MICROSCOPIC STUDY Nader Nouri Majalan,1 Houshang Sanadgol,2 Reza Ardalan,3 Erag Najafy.4 1Department of Nephrology, Sadoky medical University, Yazd, Islamic Republic of Iran; 2Department of Nephrology, Zahedan Hospital, Zahedan, Sistan, Islamic Republic of Iran; 3Department of Nephrology, Tabriz Hospital, Tabriz, Azarbaygan, Islamic Republic TH MONDAY JUNE 9 POSTERS

M721 ANALYSIS OF THE CELLULAR COMPONENT AND EXPRESSION OF GRANZIME B IN RENAL AND PANCREAS ALLOGRAFT BIOPSIES Sabrina G. Oliveira,1 Augusto P.C. Neto,1 Marcelo Perosa,2 Tércio Genzini,2 Wagner V. Dominguez,1 Hugo Abensur,2 João E. Romão, Jr.,2 Maria R.T. Araujo,2 Dino Martini Filho,2 Irene L. Noronha.1,2 1Renal Division, University of São Paulo, São Paulo, Brazil; 2Renal Division, Beneficencia Portuguesa Hospital, São Paulo, Brazil

M722 THE IMPORTANCE OF GLOMERULAR DEPOSITS OF VON WILLEBRAND FACTOR IN HUMAN RENAL ALLOGRAFTS B. Handan Ozdemir,1 Beyhan Demirhan,1 Mehmet Haberal.2 1Pathology, Baskent Univesity Faculty of Medicine, Ankara, Turkey; 2General Surgery, Baskent Univesity Faculty of Medicine, Ankara, Turkey

M723 MORPHOMETRIC AND IMMUNOPATHOLOGIC STUDY OF RENAL ALLOGRAFT BIOPSIES AND CORRELATIVE IMPLICATIONS OF CLASSIFICATION Sarah Kuruvilla, Georgi Abraham, P. Soundararajan, Anila Mathan, Sandhya Sundaram. Pathology, SriRamachandraMedical College&ResearchInstitute, Chennai, TamilNadu, India

M724 THREE-MONTH RENAL ALLOGRAFT PROTOCOL BIOPSIES: LOW RATE OF SUB-CLINICAL ACUTE REJECTION USING CYCLOSPORINE, MMF AND PREDNISONE Helen Pilmore, Philip Matheson, Ian Dittmer, John Collins, Stephen Munn. Auckland Renal Transplant Group, Auckland Hospital, Auckland, New Zealand

M725 HISTOLOGICAL FINDINGS IN PROTOCOL BIOPSIES PERFORMED IN STABLE RENAL ALLOGRAFTS ARE INFLUENCED BY IMMUNOSUPPRESSIVE SCHEDULE Francesc Moreso,1 Xavier Fulladosa,1 Marta Carrera,2 Salvador Gil-Vernet,1 Miguel Hueso,1 Josep M. Grinyo,1 Daniel Seron.1 1Nephrology, Hospital de Bellvitge, L’Hospitalet, Barcelona, Spain; 2Pathology, Hospital de Bellvitge, L’Hospitalet, Barcelona, Spain

M726 ROLE OF POST-TRANSPLANT ANTI-HLA ANTIBODY IN RENAL TRANSPLANTATION Kriengsak Vareesangthip,1 Weera Assavisaraporn,1 Wichitchai Bintaprasit,2 Sasijit Vejbaesya.2 1Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; 2Department of Transfusion Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

M727 THE FACTOR VIII OF COACULATION AS VASCULAR REJECTION MARKER Oleg Kalachik, Valery Pilotovich. 4 City Hospital, National Center of Nephrology and Kidney Transplantation, Minsk, Belarus

M728 QUANTIFICATION OF DONOR-DERIVED DNA IN SERUM OF RENAL TRANSPLANTED RATS BY REAL-TIME PCR: A NEW APPROACH FOR ACUTE REJECTION DIAGNOSIS Mir Farzin Mashreghi,1 Paulo N.A. Martins,2 Anja Reutzel-Selke,2 Hans-Dieter Volk,1 Stefan G. Tullius,2 Katja Kotsch.1 1Institute of Medical Immunology, CharitéHumboldt-University, Berlin, Germany; 2Department of Surgery, CharitéVirchow-Clinic, Humboldt-University, Berlin, Germany POSTERS MONDAY JUNE 9TH

M729 NONINVASIVE DIAGNOSIS OF ACUTE ISLET ALLOGRAFT REJECTION BY PERIPHERAL BLOOD CELL mRNA PROFILING Dolca Thomas, Hua Yang, Daniel Boffa, Ruchuang Ding, Baogui Li, Manikkam Suthanthiran. Division of Nephrology, Weill Medical College of Cornell University, New York City, NY, United States

M730 THE PREDICTIVE VALUE OF THE INTERFERON-GAMMA DEPENDENT CHEMOKINE MIG TO DIFFERENTIATE RENAL ALLOGRAFT REJECTION FROM OTHER CAUSES OF GRAFT DYSFUNCTION Heinfried H. Radeke,1 Sandra Spiegler,1 Peter Gawlik,2 Ernst H. Scheuermann,2 Matthias Kannengiesser,2 Helmut Geiger,2 Ingeborg A. Hauser.2 1Pharmazentrum Frankfurt, Clinic of the J.-W. Goethe University, MONDAY Frankfurt am Main, Germany; 2Department Nephrology, Clinic of the J.-W. Goethe University, Frankfurt am Main, Germany

M731 RESISTANCE INDEX PREDICTS LONG-TERM RENAL ALLOGRAFT SURVIVAL Joerg Radermacher,1 Michael Mengel,2 Sebastian Ellis,1 Stephan Stuht,1 Markus Hiss,1 Ute Eisenberger,1 Michael Burg,1 Friedrich C. Luft,3 Wilfried Gwinner,1 Hermann Haller.1 1Dept. of Nephrology, 2Dept. of Pathology, Hannover Medical School, Hannover, Germany; 3Dept. of Nephrology, Franz Volhard Clinic, HELIOS Klinikum-Berlin, Humboldt Univ. of Berlin, Berlin, Germany

M732 DOES URINARY IL-8 mRNA-EXPRESSION REFLECT THE ISCHEMIA/REPERFUSION INJURY (IRI)? EVALUATION OF LIVING DONOR DERIVED AND CADAVERIC KIDNEY TRANSPLANTS Volker Burst, Ruth Herzog, Petra Heid, Conrad Baldamus, Claudia Barth. Klinik IV Fuer Innere Medizin, University Hospital Cologne, Cologne, NRW, Germany

M733 CD25 mRNA LEVELS IN URINARY CELLS PREDICT ACUTE REJECTION Thangamani Muthukumar,1 Darshana Dadhania,1 Ruchuang Ding,1 Baogui Li,1 Vijay K. Sharma,1 Surya V. Seshan,2 Manikkam Suthanthiran.1 1Div. of Nephrology, Dept. of Medicine, Weill Medical College of Cornell Univ., New York, NY, USA; 2Dept. of Pathology, Weill Medical College of Cornell University, New York, NY, USA

M734 MOLECULAR SIGNATURES OF URINARY CELLS DISTINGUISH ALLOGRAFT INFILTRATES ASSOCIATED WITH ACUTE REJECTION FROM INFILTRATES THAT DO NOT CAUSE PROXIMATE ACUTE REJECTION Darshana Dadhania,1 Thangamani Muthukumar,1 Priya Anantharaman,1 Ruchuang Ding,1 Surya V. Seshan,2 Baogui Li,1 Meredith Aull,3 Choli Hartono,1 David Serur,1 Sandip Kapur,4 Manikkam Suthanthiran.1 1Div. of Nephrology, Dept. of Medicine, Weill Medical College of Cornell Univ., New York, NY, USA; 2Dept. of Pathology, Weill Medical College of Cornell Univ., New York, NY, USA; 3Dept. of Pharmacy, Weill Medical College of Cornell Univ., New York, NY, USA; 4Dept of Surgery, Weill Medical College of Cornell Univ., New York, NY, USA

M735 DETECTION OF SUBCLINICAL REJECTION AFTER RENAL TRANSPLANTATION Ana Oliveira, Alvaro Pacheco-Silva Filho, Marcello Franco, Paula Pinheiro, Jose Osmar Medina Pestana, Valdecira Maria Piveta. 1Division of Nephrology, Hosp. do Rim e Hipertensão/Univ. Federal de São Paulo, São Paulo, SP, Brazil; 2Division of Nephrology, Univ. de Alfenas- UNIFENAS, Àlfenas, MG, Brazil TH MONDAY JUNE 9 POSTERS TRANSPLANTATION: OUTCOMES, CARDIOVASCULAR MORBIDITY AND MORTALITY

M736 EFFECTS OF FLUVASTATIN ON RENAL TRANSPLANT FUNCTION AND GRAFT LOSS IN RENAL TRANSPLANT PATIENTS IN ALERT (ASSESSMENT OF LESCOL IN RENAL TRANSPLANTATION) Bengt Fellstrom,1 Hallvard Holdaas,2 Alan Jardine,3 Ingar Holme,4 Gudrun Nyberg,5 Carola Gronhagen-Riska,6 Soren Madsen,7 Hans- Hellmut Neumayer,8 Edward Cole,9 Burt Maes,10 Patrich Ambuhl,11 Anders G. Olsson,12 Terje Pedersen,13 the ALERT Study Group. 1Dt of Medical Science, Renal Unit, Univ. Hosp., Uppsala, Sweden; 2Renal Section, Dept of Medicine, National Hosp., Oslo, Norway; 3Dept of Medicine and Therapeutics, Western Infirmary Hosp., Glasgow, UK; 4Clinic of Preventive Medicine, Ullevaal Hosp., Oslo, Norway; 5Sahlgrenska Univ. Hosp., Gothenburg, Sweden; 6Univ. Hosp., Helsinki, Finland; 7Skejby Hosp., Aarhus, Denmark; 8Universitatsklinikum Charite, Berlin, Germany; 9Unive. Health Network, Toronto Hosp., Toronto, Canada; 10Univ. Hosp., Leuven, Belgium; 11Univ. Hosp., Zurich, Switzerland; 12Univ. Hosp., Linkoping, Sweden; 13Aker Hosp., Oslo, Norway

M737 EFFECTS OF FLUVASTATIN ON CARDIOVASCULAR EVENTS IN RENAL TRANSPLANT PATIENTS: ALERT (ASSESSMENT OF LESCOL IN RENAL TRANSPLANTATION) Hallvard Holdaas,1 Bengt Fellstrøm,2 Alan Jardine,3 Ingar Holme,4 Gudrun Nyberg,5 Carola Grønhagen-Riska,6 Søren Madsen,7 Hans- Hellmut Neumayer,8 Edward Cole,9 Bart Maes,10 Patrich Ambühl,11 Anders G. Olsson,12 Terje Pedersen,13 Per Fauchald,1 on Behalf of the ALERT Study Group. 1Renal Section, Dept of Medicine, National Hosp., Oslo, Norway; 2Dept of Medical Science, Renal Unit, Univ.Hosp., Uppsala, Uppsala, Sweden; 3Dept of Medicine and Therapeutics, Western Infirmary Hosp., Glasgow, UK; 4Clinic of Preventive Medicine, Ullevaal Hosp., Oslo, Norway; 5Sahlgrenska Univ. Hosp., Gothenburg, Sweden; 6Univ. Hosp., Helsinki, Finland; 7Skejby Hosp. Aarhus, Denmark; 8Universitätsklinikum CharitéBerlin, Germany; 9Univ. Health Network, Toronto Hosp., Toronto, Canada; 10Univ. Hosp., Leuven, Belgium; 11Univ. Hospital, Zürich, Switzerland; 12Univ. Hospital, Linköping, Sweden; 13Aker Hosp., Oslo, Norway

M738 ON THE IMPORTANCE OF THE MOLECULAR STATUS OF THE ALLOGRAFT AT THE TIME OF IMPLANTATION AND CLINICAL OUTCOME Yingyos Avihingsanon,1 Mauricio Giraldo,1 Asher Schachter,2 Naili Ma,1 David Shaffer,1 Anthony Monaco,1 Mark Uknis,1 Christiane Ferran,1 Isaac Stillman,1 Martha Pavlakis,1 Terry Strom.1 1Medicine, Surgery and Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School; 2Pediatric, Children’s Hospital, Boston, MA, United States

M739 CHRONIC ALLOGRAFT NEPHROPATHY RESULTS FROM CUMULATIVE DAMAGE FROM IMMUNE, ISCHEMIC AND NEPHROTOXIC INSULTS Brian Nankivell,1 Richard Borrows,1 Carolyn Fung,2 Philip O’Connell,1 Richard Allen,3 Jeremy Chapman.1 1Renal Medicine, 2Transplantation, 3Pathology, Westmead Hospital, Sydney, NSW, Australia POSTERS MONDAY JUNE 9TH

M740 RENAL TRANSPLANTATION FROM NON HEART-BEATING DONORS: LEICESTER SUPPORTS GOVERNMENT PROPOSALS FOR THE EXPANSION OF FURTHER NON-HEART-BEATING- CENTRES Julian Waller, Nicholas Brook, Amanda Richardson, Michael Nicholson. Department of Surgery, University of Leicester, Leicester, United Kingdom

M741 PATIENTS WHO RETURN TO DIALYSIS AFTER GRAFT LOSS DO NOT HAVE DISMAL SURVIVAL RATES - A CANADIAN EXPERIENCE Sarbjit V. Jassal,1 Derek Yung,1 Naisu Zhu,2 Kim Badovinac,2 Lilyanna Trpeski,2 Stanley S.A. Fenton.1 1Medicine, University Health Network, Toronto, ON, Canada; MONDAY 2Canadian Institute of Health Information, Ottawa, ON, Canada

M742 GENOME WIDE GENE EXPRESSION PATTERN OF DONOR KIDNEY BIOPSIES DISTINGUISH PRIMARY ALLOGRAFT FUNCTION Peter Hauser,1 Christoph Schwarz,1 Christa Mitterbauer,1 Heinz M. Regele,2 Ferdinand Mühlbacher,3 Gert Mayer,4 Paul Perco,1 Bernd Mayer,5 Timothy W. Meyer,6 Rainer Oberbauer.1 1Dept Nephrology, 2Dept Pathology, 3Dept Transplant Surgery, Univ Vienna, Vienna, Austria; 4Dept Nephrology, Univ Innsbruck, Innsbruck, 5Emergentec Data Analytics, Vienna, Austria; 6Dept Nephrology, Stanford Univ, Stanford, CA, United States.

M743 NON-INVASIVE MONITORING OF GRANULYSIN mRNA IN URINE: A POSSIBLE APPLICATION BY REAL-TIME RT-PCR FOR ACUTE REJECTION DIAGNOSIS IN KIDNEY TRANSPLANTATION Katja Kotsch,1 Mir Farzin Mashreghi,1 Philipp Tretow,1 Hans-Dieter Volk, Petra Reinke. 1Institute of Medical Immunology, Charité Humboldt-University, Berlin, Germany; 2Department of Nephrology, Virchow-Clinic, Charité Humboldt-University, Berlin, Germany

M744 THE ROLE OF MICROVASCULAR INJURY ON STEROID AND OKT3 RESPONSE IN RENAL ALLOGRAFT REJECTION B. Handan Ozdemir,1 Beyhan Demirhan,1 Mehmet Haberal.2 1Pathology, 2General Surgery, Baskent University School of Medicine, Ankara, Turkey

M745 COMPUTER-ASSISTED QUANTIFICATION OF FIBROSIS IN CHRONIC ALLOGRAFT NEPHROPATHY (CAN) BY PICROSIRIUSRED-STAINING: A NEW TOOL FOR PREDICTING LONG TERM GRAFT FUNCTION Lars Pape,1 Gisela Offner,1 Juergen Strehlau,1 Jochen Ehrich,1 Michael Mengel,2 Paul Grimm.3 1Pediatric Nephrology, 2Pathology, Medical School of Hannover, Hannover, Germany; 3Pediatric Nephrology, University of Southern California at San Diego, San Diego, CA, United States

M746 ESTABLISHMENT OF A mRNA EXPRESSION MARKER SET FOR THE DIFFERENTIAL DIAGNOSIS OF RENAL ALLOGRAFT REJECTION Holger Schmid,1 Anna Henger,1 Bruno Luckow,1 Clemens D. Cohen,1 Herrmann J. Groene,2 Detlef Schloendorff,1 Matthias Kretzler.1 1Nephrological Center, Medical Policlinic, Ludwig-Maximilians- University, Munich, Germany; 2Department for Molecular and Cellular Pathology, German Cancer Research Center, Heidelberg, Germany TH MONDAY JUNE 9 POSTERS

M747 IMPROVED PROGNOSIS IN POLYOMAVIRUS ASSOCIATED NEPHROPATHY - THE BENEFIT OF PROTOCOL BIOPSY AND CONVERSION TO CYCLOSPORINE Christopher Buehrig,1 Abdullah Hamad,1 Michelle Kreps,2 Donna Lager,3 Mary Fidler,3 James Gloor,1 Thomas Schwab,1 Fernado Cosio,1 Stephen Textor,1 Mark Stegall,2 Timothy Larson,1 Matthew Griffin.1 1Dept. Internal Medicine, Div. Nephrology, 2Dept. Surgery, Div. Transplantation, 3Dept. Laboratory Medicine and Anatomic Pathology; Mayo Clinic and Foundation, Rochester, MN, United States.

M748 C-REACTIVE PROTEIN SERUM LEVEL AT THE TIME OF RENAL TRANSPLANTATION (TP) IS AN INDEPENDENT PREDICTOR OF THE LONG-TERM POST-TP CARDIOVASCULAR ATHEROSCLEROTIC RISK Sylvie Hyat,1 Eric Goffin,1 Claire Beguin,2 Pierre Wallemacq,3 Yves Pirson,1 Dominique Latinne,3 Michel Jadoul.1 1Nephrology, 2Medical Informatics, 3Clinical Biology, Cliniques Universitaires St. Luc - Université Catholique de Louvain, Brussels, Belgium

M749 RENOPROTECTIVE PROPERTIES FROM THE ANTIOXIDANT AND LIPID LOWERING EFFECTS OF FLUVASTATIN IN RENAL TRANSPLANTATION Irene Konstadinidou, John N. Boletis, Despina Perrea, Ageliki Triantafyllou, Vasilis Filiopoulos, Elisabeth Stamataki, Alkiviadis Kostakis, Charalambos P. Stathakis. Transplant Center, Laiko Hospital, Athens, Greece

M750 TRADITIONAL CARDIOVASCULAR DISEASE RISK FACTORS ARE VALID FOR ASSESSMENT OF CARDIOVASCULAR RISK IN KIDNEY TRANSPLANT CANDIDATES Lutz Fritsche,1 Andreas Bock,2 Jeremy Chapman,2 Bertrand Dussol,2 John Jeffery,2 Volker Kliem,2 Yvon Lebranchu,2 Federico Oppenheimer,2 Erich Pohanka,2 Maurizio Salvadori,2 Gunnar Tufveson.2 1Med. Klinik m. S. Nephrologie, Charité Campus Mitte, Berlin, Germany; 2on Behalf of the MOST Investigators

M751 CARDIOVASCULAR RISK IN RENAL TRANSPLANT IN CATALONIA: ANALYSIS OF 2,302 PATIENTS’ DATA Frederic Cofan,1 Emili Vela,2 Montse Clèries,2 Comimittee of Renal Patients Registry of Catalonia (RMRC).2 1Renal Transplant Unit, Hospital Clínic, Barcelona, Catalonia, Spain; 2Catalan Transplant Organization (OCATT), Catalan Health Service, Barcelona, Catalonia, Spain

M752 CARDIOVASCULAR RISK FACTORS IN THE FIRST YEAR AFTER RENAL TRANSPLANT A.S. Laurés, E. Gómez, V. Alvarez, J.M. Baltar, J. Alvarez-Grande. 1Nephrology, Hospital Central De Asturias, Oviedo, Asturias, Spain; 2Genetic, Hospital Central De Asturias, Oviedo, Asturias, Spain

M753 CARDIOVASCULAR COMPLICATIONS IN 918 RENAL TRANSPLANT RECIPIENTS Mosadegh Jabbari, Shahrzad Ossareh, Ahad J. Ghods. Nephrology Department, Iran University of Medical Sciences, Tehran, Islamic Republic of Iran POSTERS MONDAY JUNE 9TH

TRANSPLANTATION: MISCELLANEOUS

M754 SUCCESSFUL OUTCOME OF POST TRANSPLANT LYMPHOPROLIFERATIVE DISORDERS IN KIDNEY TRANSPLANT RECIPIENTS Puig Josep Mª,1 Soler Mª Josep,1 Mir Marisa,1 Parrilla Josep,1 Serrano Sergi,2 Pedro Carmen,3 Salar Antonio,3 Lloveras Josep.1 1Nephrology, Hosp. del Mar, Barcelona, Spain; 2Pathology, Hosp. del Mar, Barcelona, Spain; 3Hematology, Hosp. del Mar, Barcelona, Spain

M755 SURVIVAL WITHOUT IMMUNOSUPPRESSION IN POST RENAL TRANSPLANT KAPOSI’S SARCOMA

Kashif Manzoor, Ejaz Ahmed, Raheel Aziz, Salman Imtiaz, Muhammed MONDAY Mubarak, Jawed Kazi, Fazal Akhtar, Anwar Naqvi, Adib Rizvi. Sindh Inst. of Urology and Transplantation, Dow Medical College, Karachi, Sindh, Pakistan

M756 PREVALENCE OF MALIGNANCY AFTER RENAL TRANSPLANTATION Khadijeh Makhdoomi,1 Pedram Ahmadpour,2 Ali Ghafari Moghadam,1 Rashin Rostami,1 Farokhlegha Ahmadi,2 Mahboob Lessan Pezeshki.2 1Nephrology, Urmia Medical School, Urmia, West Azarbayejan, Islamic Republic of Iran; 2Nephrology, Tehran University of Medical Science, Tehran, Islamic Republic of Iran

M757 MALIGNANCIES IN RENAL TRANSPLANT RECIPIENTS: A SINGLE-CENTER EXPERIENCE Maria Piera Scolari,1 Elena Sestigiani,2 Andrea Buscaroli,1 Stefania Cristino,1 Francesca D’Addio,1 Alessandro Faenza,3 Sergio Stefoni.1 1Nephr. Dialysis and Transpl. Unit, St.Orsola Univ. Hosp., Bologna, Italy; 2Transpl. Reference Center Emilia-Romagna, St.Orsola Univ. Hosp., Bologna, Italy; 3Dep.of Surgery and Transpl., St.Orsola Unive. Hosp., Bologna, Italy

M758 HEALTH-RELATED QUALITY-OF-LIFE ASSESSMENT IN KIDNEY TRANSPLANT PATIENTS RECEIVING SIROLIMUS MAINTENANCE THERAPY WITH EARLY ELIMINATION OF CYCLOSPORINE: 3-YEAR RESULTS Rainer Oberbauer, Brian Hutchison, Josette Eris, Manuel Arias, Alfredo Mota, the Rapamune Maintenance Regimen Study Group. Nephrology, Allgemeines Krankenhaus, Vienna, Austria

M759 DEPRESSION AND ANXIETY IN LIVING RELATED RENAL TRANSPLANT PATIENTS AND THEIR DONORS Hulya Ayaz Akay,1 Gulcin Kantarci,2 Sevgi Sahin.2 1Psychology of Nephrology, Goztepe Social Securty Teaching Hosp., Istanbul, Turkey; 2Nephrology, Goztepe Social Securty Teaching Hosp., Istanbul, Turkey

M760 TREATMENT OF ERECTILE DYSFUNCTION WITH SIDENAFIL CITRATE IN RENAL TRANSPLANT RECIPIENT: A CROSS OVER PLACEBO CONTROLLED TRIAL R.K. Sharma, N. Prasad, R. Kapoor, A. Gupta, S. Gulati, A.P. Sharma, A. Kumar, M. Bhandari. Nephrology and Urology, Sanjay Gandhi Post Graduate Inst.of Medical Sciences, Lucknow, U.P., India

M761 FERTILITY INDEXES OF MALES WITH FUNCTIONING RENAL GRAFTS Kutlay Naci Tutucu,1 Oner Sanli,2 Latife Umut Yildirim,1 Gulsen Aktan,2 Aydin Turkmen,1 Ates Kadioglu,2 Ismet Nane,2 Mehmet Sukru Sever.1 1Internal Medicine Nephrology Division, Istanbul University Istanbul School of Medicine, Istanbul, Turkey; 2Urology, Istanbul University Istanbul School of Medicine, Istanbul, Turkey TH MONDAY JUNE 9 POSTERS

M762 LAPAROSCOPIC LIVE DONOR NEPHRECTOMY: THE FIRST FORTY CASES FROM A SINGLE CENTRE Gareth R.R. Lewis, Julian R. Waller, Nicholas R. Brook, Steven A. White, Peter S. Veitch, Michael L. Nicholson. Division of Transplant Surgery, University of Leicester, United Kingdom

M763 PROLONGED NORMOTHERMIC EX-VIVO KIDNEY PERFUSION WITH AUTOLOGOUS BLOOD Nicholas Brook, Sarah Hosgood, Michael Nicholson. Department of Surgery, University of Leicester, Leicester, United Kingdom

M764 THE PREDICTIVE NATURE OF INTRA-RENAL RESISTANCE DURING MACHINE PERFUSION AFTER WARM AND COLD ISCHAEMIC DAMAGE Nicholas Brook, Julian Waller, Steven White, Amanda Knight, Michael Nicholson. Department of Surgery, University of Leicester, Leicester, United Kingdom

M765 EFFECTIVITY OF PROLONGED EPIDURAL ANALGESIA IN EARLY POSTOPERATIVE PERIOD AFTER RENAL TRANSPLANTATION Vladislav Rimashevsky, Valery Pylotovich. Kidney Transplant Department, National Centre of Nephrology and Kidney Transplantation, Minsk, Belarus

M766 SHORT -TERM COMPLICATIONS IN 469 CONSECUTIVE LIVING KIDNEY DONORS Shokoufeh Savaj, Shahrzad Ossareh, Ahad J. Ghods. Nephrology, Iran University of Medical Sciences, Tehran, Islamic Republic of Iran

M767 A PROSPECTIVE STUDY OF THE PREDICTIVE POWER OF SPIRAL CT ANGIOGRAPHY IN DELINEATING RENAL VASCULAR ANATOMY FOR LOVE DONOR NEPHRECTOMY Gareth R.R. Lewis, Nicholas R. Brook, K. Mulcahy, Peter S. Veitch, Michael L. Nicholson. Division of Transplant Surgery, University of Leicester, United Kingdom

M768 MULTIPLE ARTERIES IN RENAL TRANSPLANTATION POSTER PRESENTATION Karunagaran S. Ganesan, Ajit K. Huilgol, Sundar Shankaran, Sudhakar , Sreenivasa Prasad, T. Ravindran. Karnataka Nephrology & Transplant Institute, Lakeside Medical Center & Hospital, Bangalore, Karnataka, India

M769 USE OF THE RECOMBINANT HUMAN ERYTHROPOIETIN IN KIDNEY-TRANSPLANT PATIENTS WITH STABLE FUNCTION OF THE GRAFT Fabian Ortiz-Herbener, Lluis Guirado, Joan Diaz, Ramon Garcia- Trabanino, Nuria Garra, Montserrat Picazo, Rosa Garcia, Zulema Sainz, Antonio Alcaraz, Ricard Sola. Kidney Transplantation Unit, Fundacio Puigvert, Barcelona, Spain

M770 ANAEMIA IN RENAL TRANSPLANT RECIPIENTS IN AUSTRALIA Andrew Jefferys,1 Kevan Polkinghorne,2 Sharon Dogra,3 Claire Kanaganas,3 Rowan Walker,4 Ashley Irish,3 Steven Chadban.1,2 1Renal Medicine, Royal Prince Alfred Hosp, Sydney, NSW, Australia; 2Nephrology, Monash Med Centre, Melbourne, VIC, Australia; 3Renal Medicine, Royal Perth Hospital, Perth, WA, Australia; 4Nephrology, Royal Melbourne Hosp, Melbourne, VIC, Australia POSTERS MONDAY JUNE 9TH

M771 THE PREVELANCE OF ANEMIA AND THE CONTRIBUTING FACTORS IN RENAL TRANSPLANTATION RECIPIENTS Nurhan Seyahi,1 Burak Uzel,1 Suheyla Apaydin,1 Mehmet Riza Altiparmak,1 Muzaffer Sariyar,2 Rezzan Ataman,1 Kamil Serdengecti,1 Ekrem Erek.1 1Nephrology, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey; 2General Surgery, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey

M772 CLINICAL PREDICTORS OF THE NEED FOR PARATHYROIDECTOMY IN RENAL TRANSPLANT RECIPIENTS WITH PERSISTENT HYPERPARATHYRODISM B.Y. Choy, T.M. Chan, F.K. Li, S.L. Lui, W.K. Lo, K.N. Lai. Department of Medicine, Queen Mary Hospital, Hong Kong, China MONDAY M773 FACTORS INFLUENCING CHANGES IN BONE MINERAL DENSITY IN KIDNEY TRANSPLANT RECIPIENTS Ruzica Smalcelj,1 Vesna Kusec,1 Dunja Rogic,1 Selma Cvijetic,2 Snezana Glavas-Boras,1 Jasna Slavicek,1 Ljubica Bubic-Filipi,1 Ivan Barisic,1 Petar Kes.1 1Dialysis Department, University Hospital Center Zagreb, Zagreb, Croatia; 2Institute for Medical Research, Institute for Medical Research, Zagreb, Croatia

M774 VERTEBRAL BONE DENSITY IN RENAL TRANSPLANT PATIENTS WITH AND WITHOUT STEROIDS: 7 YEARS FOLLOW- UP Adriana Aroldi,1 Antonio Tarantino,1 Bruno Cesana,2 Giovanni Cantu,3 Claudio Ponticelli.1 1Nefrologia e Dialisi, 2Direzione Scientifica, Ospedale Maggiore IRCCS, Milano, Italia; 3Radiologia, Istituti Clinici Perfezionamento, Milano, Italia

M775 ROLE OF ALENDRONATE ON POST RENAL TRANSPLANT OSTEOPOROSIS: A RANDOMIZED STUDY R.K. Sharma, T. Jeloka, A. Gupta, S. Gupta, S. Gulati, A.P. Sharma, A. Kumar, M. Bhandari. Nephrology, Urology & Endocrinology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, U.P., India

M776 KIDNEY TRANSPLANTATION AND BONE MASS: A CONTROLLED STUDY SIX AND EIGHTEEN MONTHS AFTER SURGERY Mario Balletta,1 Pasquale Esposito,1 Marzano Luigi,1 Annalisa Ragosta,1 Bruno Minale,1 Rosa Carrano,1 Domenico Russo,1 Antonio Del Puente,2 Assunta Carpinelli,2 Stefania Padula,2 Stefano Federico.1 1Nephrology, University Federico II, Naples; 2Reumatology Unit, University Federico II, Naples, Italy

M777 PREVENTION OF OSTEOPROSIS AFTER KIDNEY TRANSPLANTATION:A PROSPECTIVE RANDOMIZED STUDY Amgad El-Agroudy, Amr El-Husseini, Moharam El-Sayed, Mohamed Ahmed Ghoneim. Nephrology, Urology & Nephrology Center, Mansoura, DK, Egypt

M778 PREVALENCE OF LOW TRAUMA FRACTURES AND OSTEOPOROSIS IN LONG-TERM KIDNEY TRANSPLANT PATIENTS WITH PRESERVED RENAL FUNCTION Jose Wilson Braga Junior,1 Raissa Maria Neves,1 Marcelo Pinheiro,1 Alberto Frisoli Junior,1 Roberto Heymann,1 Vera Lucia Szejnfeld,1 Aluizio Carvalho.2 1Internal Medicine, Rheumatology Unit, 2Internal Medicine, Nephrology Unit, Federal University of Sao Paulo, Sao Paulo, Brazil TH MONDAY JUNE 9 POSTERS PEDIATRIC NEPHROLOGY Pathophysiology, nephrotic syndrome

M779 MINIMAL CHANGE NEPHROSIS (MCN) IS ASSOCIATED WITH AN INCREASED GLOMERULAR EXPRESSION OF HEPARANASE José van den Berg,1 Jan Aten,1 Nike Claessen,1 Iris Pecker,4 Jean- Claude Davin,2 Jeroen Nauta,3 Jan J. Weening.1 1Pathology, Academic Medical Center, Amsterdam, Netherlands; 2Pediatric Nephrology, Emma Children’s Hospital, Amsterdam, Netherlands; 3Pediatric Nephrology, Sophia Kinderziekenhuis, Rotterdam, Netherlands; 4Insight Ltd., Rehovot, Israel

M780 ABNORMAL SYNTHESIS OF CYTOKINES IN NEPHROTIC SYNDROME - A CONSEQUENCE OF INCREASED OXIDATIVE STRESS? Jacek Zachwieja,1 Marcin Zaniew,1 Waldemar Bobkowski,1 Maria Lewandowska-Stachowiak,1 Agnieszka Dobrowolska-Zachwieja,2 Aldona Siwiñska.1 1Department of Pediatric Nephrology, 2Department of Gastroenterology and Human Nutrition, University of Medical Sciences, Poznan, Poland

M781 NOVEL CYTOKINE FROM IDIOPATHIC MINIMAL LESION NEPHROTIC SYNDROM (IMLNS) PATIENTS THAT INDUCES PROTEINURIA Eduardo Garin. Pediatrics, University of South Florida, Tampa, FL, United States

M782 URINARY EXCRETION AND PLASMA CONCENTRATION OF CYSTATIN C IN ACUTE PHASE OF IDIOPATHIC NEPHROTIC SYNDROME IN CHILDREN M. Tkaczyk, M. Nowicki. Dept. of Nephrology and Dialysis, Polish Mother’s Memorial Hospital Research Institute, Lodz, Poland

M783 INCREASED OSTEOPONTIN EXPRESSION AND MICROVASCULAR INJURY PRECEDE INTERSTITIAL FIBROSIS IN CYCLOSPORINE NEPHROTOXICITY OF CHILDREN WITH MINIMAL CHANGE NEPHROTIC SYNDROME Beom Jin Lim,1 Pyung Kil Kim,2 Soon Won Hong,1 Hyeon Joo Jeong.1 1Department of Pathology, College of Medicine, Yonsei University, Seoul, Korea; 2Department of Pediatrics, College of Medicine, Yonsei University, Seoul, Korea

M784 HYPERVOLEMIA IS NOT ABLE TO NORMALISE STIMULATED VASOACTIVE HORMONES IN MINIMAL LESIONS NEPHROTIC SYNDROME Reiner Mauel,1 Johan Vande Walle,1 Ann Raes,1 Raymond Donckerwolcke.2 1Paediatric Nephrology, UZ Gent, Gent, Belgium; 2Paediatrics, University Hospital, Maastricht, Netherlands,

M785 PLASMINOGEN ACTIVATOR INHIBITOR TYPE 1 GENE POLYMORPHISM IN PATIENTS WITH MINIMAL CHANGE NEPHROTIC SYNDROME (MCNS) Sung-Do Kim, Il-Soo Kim, Byung-Cheol Lee, Kang-Duk Choi, Byoung- Soo Cho. East-West Kindey Disease Research Institute, Kyung Hee Medical Center, Kyung Hee University, Seoul, Korea POSTERS MONDAY JUNE 9TH

M786 SERUM NEOPTERIN LEVELS IN CHILDREN WITH PRIMARY NEPHROTIC SYNDROME Ashraf Bakr,1 Ibrahim Rageh,2 Safaa Deyab,2 Mohamed Atwa,3 Ayman Hammad,1 Amr Sarhan.1 1Pediatrics, Mansoura University Children’s Hospital, Mansoura, Dakahlia, Egypt; 2Clinical Pathology, Banha Faculty of Medicine, Banha, Kalyobia, Egypt; 3Clinical Pathology, Mansoura University Children’s Hospital, Mansoura, Dakahlia, Egypt

M787 STUDY OF INTERLEUKIN-12 AND INTERLEUKIN-13 IN CHILDREN WITH PRIMARY NEPHROTIC SYNDROME Amr Sarhan,1 Farha El-Shenaway,2 Tarek El-Dosoky,1 Ashraf Bakr,1 Ayman Hammad,1 Housany Mahmoud.1 1Pediatrics, Mansoura University Children’s Hospital, Mansoura, Dakahlia, Egypt; 2Clinical Pathology, Mansoura University Faculty MONDAY of Medicine, Mansoura, Dakahlia, Egypt

M788 THE POSSIBLE ROLE OF PARAOXANASE 1 (PON1) ACTIVITY IN PROGRESSION OF CHILDHOOD FOCAL GLOMERULOSCLEROSIS Sevinc Emre,1 Ilmay Bilge,1 Aydan Sirin,1 Banu Sadikoglu,1 Bedia Agachan,2 Hulya Yilmaz,2 Aysegul Sucu,1 Turgay Isbir.2 1Pediatric Nephrology, University of Istanbul, Istanbul Medical Faculty, Istanbul, Turkey; 2Molecular Medicine, Institute of Experimental Medical Research, Istanbul, Turkey

M789 T CELLS TRANSCRIPTOME DURING IDIOPATHIC NEPHROTIC SYNDROME (INS) IN CHILDREN Hicham Mansour,1 Alain Doucet,1 Jean-Christophe Aude,2 Jean- Marc Elalouf,2 Georges Deschênes.3 1FRE 2468, CNRS, Paris, France; 2DBJC, CEA, Saclay, France; 3Néphrologie Pédiatrique, hôpital armand-trousseau, Paris, France

M790 DIMINISHED GLOMERULAR a-DYSTROGLYCAN ABUNDANCE IN CHILDREN WITH MINIMAL CHANGE NEPHROTIC SNYDROME (MCNS), BUT NOT FOCAL SEGMENTAL SCLEROSIS (FSGS) Cecile Dau,1 Maria Kuehne,1 Frank Autschbach,2 Otto Mehls,1 Franz Schaefer.1 1Division of Pediatric Nephrology, University Children’s Hospital, Heidelberg, Germany; 2Institution of Pathology, University of Heidelberg, Germany

M791 REGULATION OF METALLOPROTEINASES (MMP)-2 AND -9 BY INTERLEUKIN 13 (IL-13) IN MESANGIAL CELLS Cecile Dau,1 Bernhard Banas,2 Georg F. Hoffmann,1 Otto Mehls,1 Franz Schaefer.1 1Pediatric Nephrology Division, University Children’s Hospital, Heidelberg, Germany; 2Medizinische Klinik, Ludwig-Maximilians University, Munich, Germany

M792 THE LOSS OF THE SUPPRESSOR ALPHA3 INTEGRIN IN PODOCYTES LEADS TO INCREASE FOCAL CONTACT STRENGHT Jun Oh,1,2 Jochen Reiser,1 Peter Mundel.1 1Division of Nephrology, AECOM, Bronx, NY, United States; 2Division of Pediatric Nephrology, University Children Hospital, Heidelberg, Germany

M793 LEVEL OF INTERLEUKIN-5 IN PLASMA AND URINE IN CHILDREN WITH STEROID-SENSITIVE NEPHROTIC SYNDROME Olga Morozova, Elena Moskaleva, Olga Turpitko, Vladimir Dlin. Dept. of Nephrology, Inst. of Pediatrics & Child Surgery, Moscow, Russian Federation TH MONDAY JUNE 9 POSTERS PEDIATRIC CLINICAL NEPHROLOGY, ACUTE AND CHRONIC RENAL FAILURE, BONE AND MINERAL METABOLISM, ANEMIA Nephrotic syndrome

M794 MONONUCLEAR CELLS PROTEINS INVOLVED IN IDIOPATHIC NEPHROTIC SYNDROME OF CHILDHOOD: A PROTEOMIC APPROACH Elsa Gonzalez,1 Markus Kemper,2 Neuhaus Thomas,2 Eric Girardin.1 1Pediatrics, Geneva University Hospital, Geneva, Switzerland; 2Pediatrics, Kinderspital, Zurich, Switzerland

M795 NEPHRIN GENE (NPHS1) IN PATIENTS WITH MINIMAL CHANGE NEPHROTIC SYNDROME Anne-Tiina Lahdenkari,1 Marjo Kestilä,2 Christer Holmberg,1 Olli Koskimies,1 Hannu Jalanko.1 1Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland; 2Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland

M796 SPECTRUM OF PODOCYTE GENE MUTATIONS ASSOCIATED WITH NEPHROTIC SYNDROME GianMarco Ghiggeri,1 Gianluca Caridi,1 Roberta Bertelli,1 Marco Di Duca,1 Monica Dagnino,1 Francesco Emma,2 Andrea Onetti Muda,3 Francesco Scolari,4 Nunzia Miglietti,5 Gianna Mazzucco,6 Luisa Murer,7 Laura Massella,2 Gianfranco Rizzoni,2 Francesco Perfumo 1Nephrology Dept. - Lab. of Physiopathology of Uremia, G. Gaslini Inst., Genoa, Italy; 2Nephrology Unit, Bambino Gesù Hospital, Rome, Italy; 3Dept. of Experimental Medicine and Pathology, La Sapienza Univ., Rome, Italy; 4Nephrology Unit, Spedali Civili, Brescia, Italy; 5Dept. of Pediatrics, Univ., Brescia, Italy; 6Dept. of Biomedical Sciences and Human Oncology, Univ., Turin, Italy; 7Dept. of Pediatrics, Univ., Padova, Italy

M797 BONE MINERAL DENSITY AND BONE TURNOVER MARKERS IN CHILDREN WITH PRIMARY NEPHROTIC SYNDROME Ashraf Bakr, Magdy El-Zeny, Samer Abu Al-Hassan, Amr Sarhan, Ayman Hammad, Nehad Shalaby. Pediatrics, Mansoura University Children’s Hospital, Mansoura, Dakahlia, Egypt

M798 EFFECT OF AGE AT ONSET ON THE PROGNOSIS OF CHILHOOD STEROID SENSITIVE NEPHROTIC SYNDROME Ali Derakhshan, Ghamar Hashemi, Mohammad Hossein Fallah Zadeh, Gholamreza Bardestani. Pediatric Nephrology, Shiraz University of Medical Sciences, Shiraz, Fars, Iran

M799 NPHS1 WITH MUSCULAR DYSTONIA AND ATHETOSIS Hanne Laakkonen,1 Tuula Lonnqvist,1 Marja Ala-Houhala,2 Matti Nuutinen,3 Christer Holmberg.1 1Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland; 2Department of Pediatrics, Tampere University Hospital, Tampere, Finland; 3Department of Pediatrics and Adolescence, Oulu University Hospital, Oulu, Finland

M800 PODOCIN (NPHS2) GENE MUTATION IN TURKISH CHILDREN WITH STEROID RESISTANT NEPHROTIC SYNDROME Afig Berdeli,1 Erkin Serdaroglu,2 Sevgi Mir,2 Alphan Cura.2 1Molecular Medicine Laboratory, Ege University Medical School, Izmir, TR, Turkey; 2Department of Pediatric Nephrology, Ege University Medical School, Izmir, TR, Turkey POSTERS MONDAY JUNE 9TH

M801 DOES THE TYPE OF STEROID RESISTANCE HAVE PROGNOSTIC VALUE IN STEROID RESISTANT NEPHROTIC SYNDROME IN CHILDREN? S. Gulati, A. Saha, R.K. Sharma, R.K. Gupta, A. Gupta, A.P. Sharma. Nephrology & Pathology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, U.P., India

M802 DO RAS GENE (ACE AND AT1) POLYMORPHISMS AFFECT THE RISK AND OUTCOME OF FOCAL SEGMENTAL GLOMERULOSCLEROSIS? Nesrin Besbas,1 Mehmet Alikasifoglu,2 Seza Ozen,1 Fatih Ozaltin,1 Rezan Topaloglu,1 Ergul Tuncbilek,2 Aysin Bakkaloglu.1 1Pediatric Nephrology, Hacettepe University Faculty of Medicine, Ankara, Turkey; 2Clinical Genetics, Hacettepe University Faculty of Medicine, Ankara, Turkey MONDAY

M803 POLYMORPHISMS OF THE RENIN-ANGIOTENSIN SYSTEM (RAS) GENES IN CHILDREN WITH STEROID DEPENDENT AND STEROID RESPONSIVE NEPHROTIC SYNDROME Ludmila Podracká,1 J. Salagovic,2 T. Baltesova,1 J. Zidzik,2 B. Fleisher,2 A. Boor.1 1Department of Pediatrics, Medical School, Safarik University, Kosice, Slovakia (Slovak Republic); 2Department of Biology, Medical School, Safarik university, Kosice, Slovakia (Slovak Republic)

M804 A DECREASE OF THE PERMEABILITY OF THE GLOMERULAR BARRIER RATHER THAN HYPOVOLEMIA CAUSES ACUTE RENAL FAILURE IN THE NEPHROTIC SYNDROME Johan Vande Walle,1 Reiner Mauel,1 Ann Raes,1 Joke Dehoorne,1 Kristof Vandekerckhove,1 Raymond Donckerwolcke.2 1Pediatric Nephrology, UZGent, Gent, Belgium; 2Pediatrics, AZ Maastricht, Maastricht, Netherlands

M805 CHILDHOOD THIN GBM DISEASE: REVIEW OF 22 CHILDREN WITH FAMILY STUDIES AND LONG-TERM FOLLOW UP Carla Carasi,1 William G. van’t Hoff,1 Lesley Rees,1 R. Antony Risdon,2 Richard S. Trompeter,1 Michael J. Dillon.1 1Department of Nephrology, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom; 2Department of Histopathology, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom

M806 CHARCOT-MARIE-TOOTH DISEASE AND FOCAL SEGMENTAL GLOMERULOSCLEROSIS Christoph J. Mache,1 Michaela Auer-Grumbach,2 Afschin Soleiman,3 Christian Windpassinger,2 Klaus Wagner,2 Ekkehard Ring.1 1Pediatric Nephrology, University Children’s Hospital, Graz, Austria; 2Institute of Medical Biology and Human Genetics, Karl- Franzens-University, Graz, Austria; 3Institute of Clinical Pathology, University Medical School, Vienna, Austria

M807 URINARY GLYCOSAMINOGLYCAN EXCRETION IN CHILDREN WITH NEPHROTIC SYNDROME Nurcan Cengiz,1 Aysun Karabay Bayazit,2 Aytul Noyan,2 Yasemin Uslu,1 Mithat Buyukcelik,2 Hasan Dursun,2 Ali Anarat.1 1Pediatric Nephrology, Baskent University, School of Medicine, Adana Hospital, Adana, Turkey; 2Pediatric Nephrology, Cukurova University, School of Medicine, Balcali, Adana, Turkey

M808 SPECIFIC IGE AND TREATMENT AT FREQUENT RELAPSING AND STEROID-DEPENDENT MINIMAL CHANGE NEPHROTIC SYNDROME (MCNS) IN CHILDREN Nadezhda D. Savenkova, Irina V. Batrakova, Karina A. Papayan, Natalya A. Lisovaya. Department of Pediatric Nephrology, St.-Peterburg Pediatric Medical Academy, St.-Petrburg, Russian Federation TH MONDAY JUNE 9 POSTERS

M809 GROWING INCIDENCE OF FOCAL AND SEGMENTARY GLOMERULOSCLEROSIS AS A CAUSE OF STEROID-RESISTANT NEPHROTIC SYNDROME IN RUSSIAN CHILDREN Alexey Tsygin,1 Tamara Sergeeva,1 Tatiana Voznesenskaya,1 Tatiana Pankratenko,1 Vladimir Varshavsky,2 Anna Timofeeva.1 1Nephrology, Institute of Pediatrics, RCCH RAMS, Moscow, Russian Federation; 2Pathology, Moscow Medical Academy, Moscow, Russian Federation

M810 AMILORIDE POTENTIATES EDEMA REMOVAL BY FUROSEMIDE IN NEPHROTIC CHILDREN Vincent Guigonis,1 Sylvie Nathanson,1 Alain Doucet,2 Georges Deschênes.1 1Néphrologie Pédiatrique, hôpital armand-trousseau, Paris, France; 2FRE 2468, CNRS, Paris, France

M811 HAVE THE CLINICAL COURSE AND RESPONSE TO STEROID TREATMENT CHANGED IN CHILDHOOD PRIMARY NEPHROTIC SYNDROME? Ece Sule Aslan, Lale Sever, Salim Caliskan, Ozgur Kasapcopur, Nil Arisoy. Paediatric Nephrology, University of Istanbul, Cerrahpasa School of Med., Istanbul, Turkey

M812 BONE MINERAL DENSITY IN CHILDREN WITH NEPHROTIC SYNDROM TREATED WITH CORTICOSTEROIDS Mojgan Mazaheri, Taher Isfahani, Abbas Madani, Hasan Moradinejad, Parvin Mohseni. Nephrology, Children Medical Center Hosp., Tehran, Islamic Rep. of Iran

M813 ANTIPROTEINURIC AND RENOPROTECTIVE EFFECTS OF COMBINATION THERAPY WITH AN ANGIOTENSIN- CONVERTING ENZYME INHIBITOR (ACEI) AND AN ANGIOTENSIN RECEPTOR BLOCKER (ARB) FOR CHILD PATIENTS Mitsuru Okada, Kazuro Yagi, Hidehiko Yanagida, Tsukasa Takemura. Department of Pediatrics, Kinki University School of Medicine, Osaka-Sayama, Ohno-Higashi, Japan

M814 SWITCH FROM CYCLOSPORINE A (CyA) TO MYCOPHENOLATE MOFETIL IMPROVES KIDNEY FUNCTION IN CHILDREN WITH NEPHROTIC SYNDROME AND CyA-INDUCED NEPHROTOXICITY Tim Ulinski, Bruno Ranchin, Marie-Helene Said, Bernadette Parchoux, Pierre Cochat. Department of Pediatrics, Hopital Edouard-Herriot, Lyon, France

M815 MULTICENTER TRIAL OF MYCOPHENOLATE MOFETIL (MMF) IN CHILDREN WITH STEROID DEPENDENT (SD) OR FREQUENT RELAPSING (FR) NEPHROTIC SYNDROME (NS). REPORT OF THE SOUTHWEST PEDIATRIC NEPHROLOGY STUDY GROUP Ronald Hogg,1 Lisa Fitzgibbons,1 Joy Bruick,1 Martin Bunke,2 Bettina Ault,3 Noosha Baqi,4 Howard Trachtman,5 Rita Swinford.6 1Clinical Research, Medical City Dallas Hospital, Dallas, TX, USA; 2Medical Transplant Liaison Medical Affairs, Roche Laboratories, Nutley, NJ, USA; 3Pediatric Nephrology, Univ. of Tennesee, Memphis, TN, USA; 4Pediatric Nephrology, SUNY Brooklyn, Brooklyn, NY, USA; 5Pediatric Nephrology, Schneider Children’s Hospital, New Hyde Park, NY, USA; 6Pediatric Nephrology, UT Houston, Houston, TX, USA

M816 SINGLE CENTER EXPERIENCE WITH CYCLOSPORINE IN 106 CHILDREN WITH IDIOPATHIC FOCAL SEGMENTAL GLOMERULOSCLEROSIS Ihab M. Mahmoud, Fathy M. El-Bassuony, Amr A. El-Huseiny, Nabeel A. Hasan, Mohamed A. Sobh. Nephrology, Urology and Nephrology Center, Mansoura, Dakahlia, Egypt POSTERS MONDAY JUNE 9TH

M817 EFFICACY AND TOLERANCE OF LONG-TERM PULSE METHYLPREDNISOLONE THERAPY IN CHILDREN WITH SEVERE IDIOPATIC NEPHROTIC SYNDROME Paraschiva Chereches-Panta, Sorin Man, Mirela Popa, Mircea Nanulescu. IIIrd Pediatric Clinic, University of Medicine, Cluj Napoca, Romania

M818 LONG-TERM CYCLOSPORINE TREATMENT IN CHILDREN WITH STEROID-DEPENDENT NEPHROTIC SYNDROME: A CLINICAL AND HISTOLOGIC ANALYSIS Stefano Rinaldi,1 Antonella Sesto,1 Paola Barsotti,2 Tullio Faraggiana,2 Gianfranco Rizzoni.1 1Division of Nephrology, Bambino Gesù Children’s Hospital and Research Institute, Rome, Italy; 2Department of Pathology, University “La Sapienza”Rome, Italy MONDAY

M819 REMISSION OF CYCLOSPORIN-STEROID-RESISTANT NEPHROTIC SYNDROME USING MULTIPLE IMMUNOSUPPRESSION Vincent Guigonis,1 Tim Ulinski,1 Françoise Audat,2 François Lefrere,2 Philippe Jouvet,3 Albert Bensman,1 Georges Deschênes.1 1Pediatric nephrology, Hôpital Trousseau, Paris, France; 2Hematology, Hôpital Necker, Paris, France; 3Pediatric Intensive Care Unit, Hôpital Necker, Paris, France

M820 PLASMA EXCHANGE AND IMMUNOSUPPRESSION – AN INDIVIDUALLY TAILORED APPROACH TO THE TREATMENT OF PRIMARY AND RECURRENT FOCAL SEGMENTAL GLOMERULOSCLEROSIS IN CHILDREN Catherine O’Brien,1 Mary McGraw,1 E. Jane Tizard,1 Edwin Massey,2 Moin Saleem.1 1Children’s Renal Unit, Bristol Hospital for Children, Bristol, United Kingdom; 2Apheresis Unit, National Blood Service, Bristol, United Kingdom

M821 AUTOIMMUNE THYROIDITIS IN A CHILD WITH CORTICODEPENDENT NEPHROTIC SYNDROME TREATED WITH LEVAMISOLE Velibor Tasic,1 Meri Angjeleska,2 Nadica Ristoska-Bojkovska,1 Gordana Petrusevska,3 Zoran Gucev.1 1Pediatric Nephrology and Endocrinology, Clinic for Children’s Diseases, Skopje, Macedonia, The Former Yugoslav Republic of; 2Dept. of Pathophysiology and Nuclear Medicine, School of Medicine, Skopje, Macedonia, The Former Yugoslav Republic of; 3Dept. of Pathology, School of Medicine, Skopje, Macedonia, The Former Yugoslav Republic of Macedonia TH MONDAY JUNE 9 POSTERS PEDIATRIC CLINICAL NEPHROLOGY, ACUTE AND CHRONIC RENAL FAILURE, BONE AND MINERAL METABOLISM, ANEMIA Miscellaneous

M822 OBESITY RELATED PROTEINURIA AND PROGRESSION OF RENAL DISEASE IN CHILDREN OF EXTREME LOW BIRTH WEIGHT Carolyn Abitbol,1 Maria Rodriguez,2 Brenda Montane,1 Jayanthi Chandar,1 Gaston Zilleruelo.1 1Pediatrics, University of Miami/Holtz Children’s Hospital, Miami, FL, United States; 2Pathology, University of Miami/ Holtz Center, Miami, FL, United States

M823 VALUE OF ANTEROPOSTERIOR RENAL PELVIS DIAMETER DIAGNOSED BY PRENATAL ULTRASOUND AS AN INDICATOR OF UROPATHY Maria Candida Bouzada, Eduardo Oliveira, Andrea Rodrigues, Livia Fagundes, Alamanda Pereira, Henrique Leite. Department of Pediatrics, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

M824 MICTURATING CYSTOURETHROGRAM IN INFANTS WITH FETAL HYDRONEPHROSIS Maria Candida Bouzada, Eduardo Oliveira, Andrea Rodrigues, Ricardo Parreiras, Ricardo Gonçalves, Alamanda Pereira. Department of Pediatrics, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

M825 OUTCOME OF POSTERIOR URETHRAL VALVES TREATED AT A SINGLE UNIT - MULTIFACTORIAL ANALYSIS OF PREDICTORS OF OUTCOME Leigh Haysom, Fiona Mackie, Robert H. Farnsworth, Andrew R. Rosenberg, Gad Kainer. Department of Paediatric Nephrology, Sydney Children’s Hospital, Randwick, NSW, Australia

M826 GLOMERULAR FILTRATION RATE IN BOYS WITH HISTORY OF SUCCESFUL RESECTION OF POSTERIOR URETHERAL VALVES - THE VALUE OF CYSTATIN C MEASUREMENT Marcin Tkaczyk,1 Anna Rogowska-Kalisz,1 Jolanta Lukamowicz,2 Michal Nowicki.1 1Deparment of Nephrology and Dialysis, Polish Mother’s Memorial Hospital Research Institute, Lódz, Poland; 2Laboratory Unit, Polish Mother’s Memorial Hospital Research Institute, Lódz, Poland

M827 DIAGNOSTIC VALUE OF URINARY MICROALBUMIN IN CHILDREN WITH ASYMPTOMATIC HEMATURIA Larisa Prikhodina,1 Vladimir Dlin,1 Gennady Raba,2 Olga Morozova,1 Maya Ignatova.1 1Nephrology, Institute of Paediatrics & Child’s Surgery, Moscow, Russian Federation; 2Lab. of Pathology, Institute of Paediatrics & Child’s Surgery, Moscow, Russian Federation

M828 OCCULT SPINAL DYSRAPHISM IN ENURETIC CHILDREN Nese Karaaslan Biyikli,1 Aida Semic Jusufagic,1 Tufan Tarcan,2 Harika Alpay.1 1Pediatric Nephrology, Marmara University Faculty of Medicine, Istanbul, Turkey; 2Urology, Marmara University Faculty of Medicine, Istanbul, Turkey POSTERS MONDAY JUNE 9TH

M829 CONSERVATIVE MANAGEMENT AND FOLLOW-UP OF MULTICYSTIC DYSPLASTIC KIDNEY DETECTED BY FETAL SONOGRAPHY Eduardo Oliveira, Jose Silverio Diniz, Eli Rabelo, Jose Penido Silva, Isabela Pezutti, Maria Candida Viana. Department of Pediatrics, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

M830 OUTCOME OF APPARENT URETEROPELVIC JUNCTION OBSTRUCTION IDENTIFIED BY INVESTIGATION OF FETAL HYDRONEPHROSIS Eduardo Oliveira, Guilherme Apocalypse, Eli Rabelo, Jose Silverio Diniz, Viviane Marino, Carlos Simal, Maria Candida Viana, Guilherme Silva. Pediatrics, Federal Univ. of Minas Gerais, Belo Horizonte, Minas MONDAY Gerais, Brazil

M831 EFFECT OF INTERFRENTIAL CURRENT ON ENRESIS IN CHILDREN Mohammad Hossein Fallahzadeh,1 M. Ebrahimian,1 F. Fallahzadeh,1 A. Piri.1 1Pediatric Nephrology, Shiraz Univ. of Medical Sciences, Shiraz, Fars, Islamic Republic of Iran; 2Pediatrics, Shiraz Univ. of Medical Sciences, Shiraz, Fars, Islamic Republic of Iran; 3Physical Therapy&Rehabilitation, Shiraz Univ. of Medical Sciences, Shiraz, Fars, Islamic Republic of Iran; 4Physical Therapy&Rehabilitation, Shiraz Univ. of Medical Sciences, Shiraz, Fars, Islamic Republic of Iran

M832 THE CLINICAL IMPORTANCE OF ULTRASOUND DIAGNOSIS OF RENAL CALYCEAL MICROCALCIFICATION IN CHILDREN Ilmay Bilge, Aydan Sirin, Sevinc Emre, Banu Sadikoglu, Alev Kadioglu, Aysegul Sucu. Pediatric Nephrology, Univ. of Istanbul, Istanbul Medical Faculty, Istanbul, Turkey

M833 URINARY N-ACETYL-BETA-D-GLUCOSAMINIDASE LEVELS AS AN INDEX OF RENAL TUBULAR FUNCTION IN CYANOTIC AND ACYANOTIC CONGENITAL HEART DISEASE Pinar Isik Agras,1 Esra Baskin,1 Murat Derbent,1 Figen Ozcay,1 Derya Aldemir,2 Kursad Tokel,3 Umit Saatci.1 1Pediatric Nephrology, Baskent University, Ankara, Turkey; 2Biochemistry, Baskent University, Ankara, Turkey; 3Pediatric Cardiology, Baskent University, Ankara, Turkey

M834 IS PRENATAL DIAGNOSIS OF BENEFIT IN BOYS WITH POSTERIOR URETHRAL VALVES? Ekkehard Ring,1 Christoph J. Mache,1 Martin Häusler,2 Barbara Pertl,2 Michael Riccabona,3 Peter Vilits.4 1Dept of Pediatrics, Univ. Hospital, Graz, Austria; 2Dept of Obstetrics, Univ. Hospital, Graz, Austria; 3Dept of Radiology, Univ. Hospital, Graz, Austria; 4Dept of Urology, Univ. Hospital, Graz, Austria

M835 SUPRA NORMAL RENAL FUNCTION IN UNILATERAL HYDRONEPHROSIS. COMPARATIVE STUDY WITH MAG3 AND DMSA SCINTIGRAPHY IN CHILDREN François Bouissou,1 Anne Julian,2 Eric Ouhayoun,2 Jacques Moscovici,3 Christine Azema,1 Stéphane Decramer.1 1Néphrologie Pédiatrique, Hôpital des Enfants, Tpulouse, France; 2Médecine Nucléaire, CHU Purpan, Toulouse, France; 3Urologie Pédiatrique, Hôpital des Enfants, Toulouse, France

M836 FEMALE URETHRAL MEATAL STENOSIS - MYTH OR FACT? Barbara Socik,1 Tomasz Jarmolinski,1 Mariusz Antoszewski,2 Stanislaw Paradowski.2 1Dept of Nephrology and Dialysis, District Children’s Hosp., Szczecin, Poland; 2Dept of Pediatric Surgery, District Children’s Hosp., Szczecin, Poland TH MONDAY JUNE 9 POSTERS

M837 CONGENITAL DEFECTS OF THE URINARY TRACT (UT) IN CHILDREN AGED 0-3 YEARS Grazyna Krzemien, Agnieszka Szmigielska, Maria Roszkowska- Blaim, Izabella Kostro, Monika Karpinska. Department of Pediatric Nephrology, Medical University of Warsaw, Warsaw, Poland

M838 ASSOCIATION BETWEEN GENES CONDITIONING LOW RENIN ANGIOTENSIN SYSTEM ACTIVITY (RAS) AND SEVERE HYPODYSPLASTIC CONGENITAL NEPHROPATHY Federica Lombardo,1 Licia Peruzzi,1 Alessandro Amore,1 Monica Chiesa,1 Roberta Bretto,2 Mirko Ferrigno,2 Cristina Zambelli,2 Maria Chiara Russo,2 Emilio Merlini,3 Leandra Silvestro,2 Gabriella Restagno,4 GianCarlo Mussa,2 Rosanna Coppo.1 1Nephrology Dialysis Transplantation, Regina Margherita Children’s Hospital, Torino, Italy; 2Pediatric Clinic, University, Torino, Italy; 3Pediatric Surgery, Ospedale Maggiore della CaritàNovara, Italy; 4Clinical Pathology, Regina Margherita Children’s Hospital, Torino, Italy

M839 BLADDER SHAPE IMPACT ON THE ULTRASONIC MEASUREMENT OF BLADDER VOLUME IN CHILDREN Andrea Cvitkovic Kuzmic,1 Boris Brkljacic,2 Davor Ivankovic.3 1Department of Pediatric Nephrology, Children’s Hospital Zagreb, Zagreb, Croatia; 2Department of Radiology, University Hospital Dubrava, Zagreb, Croatia; 3Department of Medical Statistics, University of Zagreb, Zagreb, Croatia

M840 WHICH PARAMETERS ARE RELEVANT TO PREDICT THE RISK OF RENAL DETERIORATION IN WATCHFUL WAITING FOR URETEROPELVIC JUNCTION (UPJ) OBSTRUCTION? Stefan Conrad,2 Markus Kemper,3 Thilo Eggert,2 H. Huland,2 Dirk E. Mueller-Wiefel.1 1Pediatric Nephrology, University Children‘s Hospital, Hamburg, Germany; 2Urology, University Hospital, Hamburg, Germany; 3Pediatric Nephrology, Children‘s Hospital, Zürich, Switzerland

M841 DEVELOPMENTS IN THE ULTRASOUND IMAGING OF VESICO- URETERAL REFLUX IN CHILDREN Maurizio Bosio. Paediatric Nephrology and Ultrasonography, Italian Diagnostic Centre, Milan, Italy

M842 PRO- AND ANTI-INFLAMMATORY CYTOKINES IN CHILDREN WITH VESICO-URETERAL REFLUX Svetlana Paunova,1 Alla Kucherenko,2 Ivan Smirnov,2 Elena Olchova,3 Olga Anochina.1 1Chair of pediatrics, Russian State Medical University, Moscow, Russian Federation; 2Dpt of Pathophysiology, RAMS Research Institute, Moscow, Russian Federation; 3Dpt of Ultrasound Investig., St.Vladimir’s Childrens’ Hospital, Moscow, Russian Federation

M843 BLOOD PRESSURE AND RENAL FUNCTION IN 19 YEAR OLD ADULTS AFTER INTRA UTERINE GROWTH RETARDATION AND PREMATURE BIRTH Mandy G. Keijzer-Veen,1,2 Martijn J.J. Finken,2,3 Jeroen Nauta,1 Friedo W. Dekker,2 Elysee T.M. Hille,4 Jan Maarten Wit,3 Bert J. van der Heijden.1 1Pediatric Nephrology, Erasmus Medical Center Rotterdam - Sophia Children’s Hospital, Rotterdam, Netherlands; 2Clinical Epidemiology, 3Pediatrics, Leiden University Medical Center, Leiden, Netherlands; 4Prevention and Health, TNO, Leiden, Netherlands POSTERS MONDAY JUNE 9TH

M844 24 HOUR AMBULATORY BLOOD PRESSURE (ABPM) IN CHILDREN. DO THE LIMITS WE SET AFFECT CLINICAL DECISIONS? Sean Kennedy, Gad Kainer, Andrew R. Rosenberg, Fiona Mackie. Department of Nephrology, Sydney Children’s Hospital, Randwick, Sydney, NSW, Australia

M845 VARIABILITY IN INTERPRETATION OF PAEDIATRIC AMBULATORY BLOOD PRESSURE MONITORING Sean Kennedy, Gad Kainer, Andrew R. Rosenberg, Fiona Mackie. Nephrology, Sydney Children’s Hospital, Randwick, Sydney, NSW, Australia

M846 CHANGES OF ARTERIAL BLOOD PRESURE IN THE TEST WITH PHISICAL LOAD IN TYPE 1 DIABETIC CHILDREN MONDAY Tatiana Nastausheva, Irina Kuznetsova, Lilia Stakhourlova, Alexandra Nastausheva, Anatoly Shvirev. 1Pediatric Department, Medical Academy, Voronezh, Russian Federation; 2Regional Children Hospital, Voronezh, Russian Federation

M847 ANGIOTENSIN-CONVERTING ENZYME GENOTYPE IN CHILDREN AND YOUNG ADULTS WITH DIABETES MELLITUS TYPE 1 AND FAMILIAL HISTORY OF HYPERTENSION AND CARDIOVASCULAR DISEASES Terezie Šuláková,1 Alena Kloudová,5 Josef Gut,2 Vlasta Janštová,1 Jana Cerná,1 Andrzej Ciechanowicz,8 Grazyna Adler,8 Lenka Kocinová,2 Nad´a Filaková,3 Helena Strmenová,4 Andrzej Brodkiewicz,7 Jaroslav Hubácek.6 1Dpt of Paediatrics, University Hospital, Ostrava, Czech Republic; 2Dpt of Paediatrics, Regional Hospital, Ceská Lípa, Czech Republic; 3Dpt of Pediatrics, City Hospital, Ostrava, Czech Republic; 4Dpt of Paediatrics, Regional Hospital, Havírov, Czech Republic; 5Dpt of Immunology and Allergology, Institute of Public Health, Ostrava, Czech Republic; 6Lab Athero Res, IKEM, Praha, Czech Republic; 7Dpt of Paediatrics, Pomerian Medical University, Szczecin, Poland; 8Dpt of Pathobiochemistry and Molecular Biology, Pomerian Medical University, Szczecin, Poland

M848 EVIDENCE FOR A GLOBAL ACTIVATION OF CIRCULATING RENIN ANGIOTENSIN SYSTEM IN PEADIATRIC DIABETIC PATIENTS Ana Cristina Simoes e Silva, Augusto Cesar Soares dos Santos Junior, Mariana Guimaraes Penido, Patricia P.C.A. Salgado. Departamento de Pediatria, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

M849 OXIDATIVE STRESS AND GLOMERULAR HYPERFILTRATION IN YOUNG DIABETIC PATIENTS WITH GOOD GLYCEMIC CONTROL Roberto Hernández,1,2 Sara Pons,1 Victoria Valls,2 Pilar Codoñer,2 Juan Marín,1 Jaime Fons,2 Laura Boix,2 M. Carmen Torres.2 1Unidad de Diabetes Infantil, Hospital Dr. Peset, Valencia, Spain; 2Dept. Pediatría, Obstetricia y Ginecología, Universidad de Valencia, Valencia, Spain

M850 THE RELATION OF SOLUBLE ADHESION MOLECULES TO MICROALBUMINURIA IN EGYPTIAN CHILDREN WITH INSULIN DEPENDENT DIABETES MELLITUS Hesham Safouh,1 Hesham Elhefnawy,2 Ghada Anwar,1 Nehad Mosaad,3 Ibrahim Ibrahim.2 1Pediatrics, Pediatric Nephrology Unit, Cairo University, Cairo, Egypt; 2Pediatrics, National Institute of Diabetes and Endocrinology, Cairo, Egypt; 3Clinical Pathology, Cairo University, Cairo, Egypt TH MONDAY JUNE 9 POSTERS

M851 PRELIMINARY EXPERIENCES WITH RECOMBINANT URATE OXIDASE (FASTURTEC) FOR PREVENTION OF HYPERURICEMIA IN CHILDREN WITH LEUKEMIA OR LYMPHOMA Edit Bardi,1 Istvan Szegedi,1 Erzsebet Udvardi,2 Csongor Kiss,1 Imre Renyi.3 1Pediatrics, University of Debrecen Medical and Health Scince Center Medical School, Debrecen, Hungary; 2Sanofi-Synthelabo Hungary Co. LTD., Budapest, Hungary; 31st Pediatrics, Semmelweis University, Faculty of Medicine, Budapest, Hungary

M852 USE OF CLEAN INTERMITTENT CATHETERIZATION (CIC) IN PREVENTING CHRONIC RENAL DAMAGE IN CHILDREN WITH NEUROGENIC BLADDER DUE TO MYELOMENINGOCELE Randall Lou,1 Evelyn Valenzuela.2 1Pediatric Nephrology, Instituto Guatemalteco de Seguridad Social, Guatemala, Guatemala; 2Pediatrics, Instituto Guatemalteco de Seguridad Social, Guatemala, Guatemala

M853 CHILDHOOD RENOVASCULAR DISEASE - 30 YEARS EXPERIENCE Suzanne Stephens, Vanita Shah, Michael Dillon. Nephrourology, Institute of Child Health, London, United Kingdom

M854 BISPHOSPHONATES FOR TREATMENT OF HYPERCALCEMIA SECONDARY TO ACUTE VITAMIN D INTOXICATION N. Yildiz,1 A. Fedakar,1 M. Yildiz,2 U.Y. Denizmen,1 M. Erguven.1 1Department of Pediatric Nephrology; 2Pediatric Endocrinology, SSK Goztepe Education Hospital, Turkey

M855 CLINICAL ASPECTS OF PLASMAPHERESIS THERAPY IN CHILDREN - EXPERIENCE WITH SIX HUNDREDS SESSIONS Jacek Rubik, Ryszard Grenda, Sylwester Prokurat, Katarzyna Jobs, Ewa Smirska, Joanna Latoszynska, Mieczyslaw Litwin, Bogdan Materna. Nephrology & Kidney Transplantation, Children’s Memorial Health Institute, Warsaw, Poland POSTERS MONDAY JUNE 9TH

PEDIATRIC CLINICAL NEPHROLOGY, ACUTE AND CHRONIC RENAL FAILURE, BONE AND MINERAL METABOLISM, ANEMIA Cronic renal failure

M856 DOES LATE REFERRAL TO A NEPHROLOGIST CONSTITUTE A PROBLEM IN CHILDREN STARTING RENAL REPLACEMENT THERAPY IN POLAND? - A NATIONWIDE STUDY Michal Nowicki,1 Anna Jander,1 Marcin Tkaczyk,1 Maria Roszkowska-Blaim,2 Tomasz Jarmolinski,3 Ewa Marczak,4 Ewa Paluba,5 Jacek A. Pietrzyk,6 Grzegorz Siten,7 Roman Stankiewicz,8 MONDAY Krystyna Szprynger,9 Malgorzata Zajaczkowska,10 Jacek Zachwieja,11 Walentyna 1Pediatric Nephrology, Centers, In Lodz; 2Warszawa; 3Szczecin; 4Gdansk; 5Sandomierz; 6Krakow; 7Rzeszow; 8Torun; 9Zabrze; 10Lublin; 11Poznan; 12Bialystok; 13Wroclaw, Poland M857 EFFICACY OF RAMIPRIL MONOTHERAPY IN CHILDREN WITH CHRONIC RENAL FAILURE Elke Wühl, Otto Mehls, Franz Schaefer, ESCAPE Trial Group. Pediatric Nephrology, University Children’s Hospital, Heidelberg, Germany M858 RISK FACTORS OF CHRONIC RENAL FAILURE PROGRESSION IN CHILDREN WITH CHRONIC, NON-GLOMERULAR NEPHROPATHIES AND NIL TO MODERATE PROTEINURIA Mieczyslaw Litwin. Dept. of Nephrology & Kidney Transplantation, The Children’s Memorial Health Institute, Warsaw, Poland M859 RENAL FUNCTIONS IN CHILDHOOD OBESITY Oguz Soylemezoglu, Elif Cingi, Esin Ozgur, Aysun Bideci, Mustafa Unlu. Pediatric Nephrology and Endocrinology, Gazi University Hospital, Ankara, Turkey M860 SENSORNEURAL HEARING LOSS IN CHILDREN WITH END- STAGE RENAL DISEASE Seyed Taher Esfahani,1 Abbas Madani,1 Nematollah Ataei,1 Parvin Mohseni,1 Ziba Ghanbari,1 Abbas Nadimi Tehrani.2 1Department of Pediatric Nephrology, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran; 2Department of Otorhinolaryngology, Tehran University of Medical Sciencess, Tehran, Islamic Republic of Iran M861 NUTRITIONAL ASSESSMENT OF CHILDREN WITH CHRONIC RENAL FAILURE: USEFULNESS OF BIOELECTRICAL IMPEDANCE Carla Simao, Fernando Batista, Zelia Patricio, Margarida Almeida. Pediatric Clinic, Hospital de Santa Maria, Lisbon, Portugal M862 THE COMPARISON OF SERUM CREATININE AND SERUM CYSTATIN C FOR DETECTION OF RENAL FAILURE IN SPINA BIFIDA PATIENTS Sevinc Cabukoglu,1 Harika Alpay,1 Nese Karaaslan Biyikli,1 Omid A. Noshari,2 Guler Topcu.3 1Pediatric Nephrology, Marmara University Faculty of Medicine, Istanbul, Turkey; 2Nucleer Medicine, Marmara University Faculty of Medicine, Istanbul, Turkey; 3Biochemistry, Marmara University Faculty of Medicine, Istanbul, Turkey TH MONDAY JUNE 9 POSTERS

M863 SKELETAL DISPROPORTION AND PUBERTAL STATUS IN CHILDREN AND ADOLESCENTS WITH CHRONIC RENAL FAILURE Nadia Qayyum,1 Heather Maxwell,2 James Beattie,2 Ian Ramage,2 Faisal Ahmed.1 1Department of Child Health, Royal Hospital for Sick Children, Glasgow, United Kingdom; 2Renal Unit, Royal Hospital for Sick Children, Glasgow, United Kingdom

M864 DISPROPORTIONATE GROWTH IN CHILDREN WITH CHRONIC RENAL FAILURE Miroslav Zivicnjak,1 Doris Franke,1 Jochen H.H. Ehrich,1 Dieter Haffner,2 Uwe Querfeld.2 1Pediatric Nephrology, Children´s Hospital, Medical School, Hannover, Germany; 2Pediatric Nephrology, Charité University Hospital, Berlin, Germany

M865 PULMONARY FUNCTION ALTERATIONS IN CHRONIC RENAL FAILURE AND END-STAGE RENAL DISEASE EGYPTIAN CHILDREN Neveen Soliman,1 Bahia Moustafa,1 Samiha Samuel,1 Hany Gamal,2 Azza Ashour.1 1Pediatric Department, Cairo University, Cairo, Egypt; 2Physiology Department, Cairo University, Cairo, Egypt

M866 ARTERIAL CHANGES IN PEDIATRIC PATIENTS WITH END- STAGE RENAL DISEASE (ESRD) Helena Ziolkowska,1 Michal Brzewski,2 Maria Roszkowska- Blaim.1 1Department of Pediatrics and Nephrology, Medical University of Warsaw, Warsaw, Poland; 2Department of Pediatric Radiology, Medical University of Warsaw, Warsaw, Poland

M867 OUTCOME OF CONSERVATIVELY MANAGED CHRONIC RENAL INSUFFICIENCY BY A INTERDISCIPLINARY PROTOCOL: A LONGITUDINAL STUDY Eleonora Lima, Jose Silverio Diniz, Cristina Bouissou, Gilce Rodrigues, Monica Vasconcelos, Eduardo Oliveira, Patricia Vieira, Flavia Gazolla, Flavia Silveira. Department of Pediatrics, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil

M868 ELECTRON BEAM TOMOGRAPHY IN END STAGE RENAL DISEASE IN CHILDREN Peter Varga,1 Eunice John,1 Adisorn Lumpaopang,1 Maria Serrato,2 Enrico Benedetti.3 1Pediatrics, University of Illinois at Chicago, Chicago, IL, United States; 2Pediatrics, Cook County Hospital, Chicago, IL, United States; 3Surgery, University of Illinois at Chicago, Chicago, IL, United States

M869 SERUM ADIPONECTIN (S-ADPN) CONCENTRATION INCREASES WITH THE SEVERITY OF CHRONIC RENAL FAILURE (CRF) IN CHILDHOOD Kristina Zepf, Maike Westphal, Dirk E. Mueller-Wiefel. Pediatric Nephrology, University Children‘s Hospital, Hamburg, Germany

M870 PARATHYROID HORMONE, GROWTH AND BONE DENSITY IN CHILDREN WITH CHRONIC RENAL FAILURE Simon Waller,1 Deborah Ridout,2 Thomas Cantor,3 Ping Gao,3 Lesley Rees.1 1Nephro-Urology, Institute of Child Health and Great Ormond Street Hospital, London, United Kingdom; 2Paediatric Epidemiology and Biostatistics, Institute of Child Health, London, United Kingdom; 3Scantibodies Laboratories Inc., Santee, CA, United States POSTERS MONDAY JUNE 9TH

M871 ANTIOXIDANT VITAMINS IN PEDIATRIC PATIENTS WITH CHRONIC RENAL FAILURE Mohamed Salah Faheem,1 Ihab Zaki El-Hakim,1 Sanaa Eissa,2 Mayssa Khalil.1 1Pediatrics, Ain Shams University, Cairo, Egypt; 2Biochemistry, Ain Shams University, Cairo, Egypt

M872 STUDY OF THE HOMOCYSTEINE STATUS IN CHILDREN WITH CHRONIC RENAL FAILURE Farida A. Farid,1 Mohamed S. Faheem,1 Nahla M. Heshmat,1 Karim Y. Shaheen,2 Sherine S. Saad.1 1Pediatrics, Ain Shams University, Cairo, Egypt; 2Clinical Pathology, Ain Shams University, Cairo, Egypt

M873 LEFT VENTRICULAR HYPERTROPHY (LVH) IN CHILDREN WITH MONDAY MILD-TO-MODERATE CHRONIC RENAL FAILURE (CRF) Stefano Picca,1 Maria Chiara Matteucci,1 Gabriele Rinelli,2 Franz Schaefer,3 Elke Wuhl,3 Gianfranco Rizzoni,1 Otto Mehls.3 1Division of Nephrology and Dialysis, Bambino Gesù Children’s Hospital and Research Institute, Rome, Italy; 2Division of Cardiology, Bambino Gesù Children’s Hospital and Research Institute, Rome, Italy; 3Division of Pediatric Nephrology, University’s Chil

M874 PAEDIATRIC RENAL REPLACEMENT THERAPY IN GERMANY: FACTS AND FIGURES OF THE QUASI-NIERE-REGISTRY Hans-Juergen Schober-Halstenberg, Kirsten Haas, Guenther Edenharter, Gisela Offner, Ulrich Frei. Quality Assurance, QuaSi-Niere gGmbH, Berlin, Germany TH MONDAY JUNE 9 POSTERS PEDIATRIC TRANSPLANTATION Immunology

M875 PROLONGED B-LYMPHOPENIA AFTER RITUXIMAB TREATMENT Marc Lilien,1 Tom Revesz,2 Ger Rijkers.3 1Pediatric Nephrology, University Medical Center, Utrecht, Netherlands; 2Pediatric Hematology and Oncology, University Medical Center, Utrecht, Netherlands; 3Laboratory for Pediatric Immunology, University Medical Center, Utrecht, Netherlands

M876 HIGH PRETRANSPLANT SERUM sCD30 CONTENT AS A POSSIBLE EXPLANATION FOR THE HIGH REJECTION RATE IN YOUNG KIDNEY GRAFT RECIPIENTS Caner Suesal, Steffen Pelzl, Gerhard Opelz for the Collaborative Transplant Study. Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany

M877 IS THERE A DRUG INTERACTION BETWEEN MMF AND TACROLIMUS IN CHILDREN? Guido Filler,1 Roberta Berard,1 Nathalie Lepage,2 Steffen Bauer,3 Ingrid Mai.3 1Pediatrics, Division of Nephrology, Children’s Hospital of Eastern Ontario, Ottawa, ON, Canada; 2Laboratory Medicine, Children’s Hospital of Eastern Ontario, Ottawa, ON, Canada; 3Clinical Pharmacology, Charite - Humboldt University at Berlin, Berlin, Germany

M878 C4d EXPRESSION IN PEDIATRIC RENAL TRANSPLANT BIOPSIES Helen Liapis, Veena Rajaram, Ann Beck, Daniel Brennan. Pathology and Immunology, Pediatrics and Medicine, Washington University, St Louis, MO, United States

M879 DIAGNOSING ALLOGRAFT REJECTION - ARE THE BANFF 97 CRITERIA ACHIEVABLE IN PAEDIATRIC RENAL TRANSPLANT BIOPSIES? Anne Durkan,1 Jim Beattie,1 John McColl,2 Alan Howatson,3 Heather Maxwell,1 Anna Murphy,1 Ian Ramage.1 1Paediatric Nephrology, Royal Hospital for Sick Children, Glasgow, Scotland, United Kingdom; 2Department of Statistics, Glasgow University, Glasgow, Scotland, United Kingdom; 3Pathology Department, Royal Hospital for Sick Children, Glasgow, Scotland, Unit