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APPENDIX A: SARA Title III Extremely Hazardous Substances

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A Appendix A: P SARA Title III P Extremely Hazardous E Substances N D I X A APPENDIX A: SARA Title III Extremely Hazardous Substances SARA Title III EXTREMELY HAZARDOUS SUBSTANCES CAS EHS NAME TPQ* CAS EHS NAME TPQ* 108054 Acetic acid ethenyl ester 1,000 534076 Bis(chloromethyl) ketone 10/10,000 75865 Acetone cyanohydrin 1,000 4044659 Bitoscanate 500/10,000 1752303 Acetone thiosemicarbazide 1,000/10,000 10294345 Borane, trichloro- 500 107028 Acrolein 500 7637072 Borane, trifluoro- 500 79061 Acrylamide 1,000/10,000 10294345 Boron trichloride 500 107131 Acrylonitrile 10,000 7637072 Boron trifluoride 500 814686 Acrylyl chloride 100 Boron trifluoride compound with 353424 methyl ether (1:1) 1,000 111693 Adiponitrile 1,000 Boron, trifluoro[oxybis[methane]]-, (T- 116063 Aldicarb 100/10,000 353424 4)- 1,000 309002 Aldrin 500/10,000 28772567 Bromadiolone 100/10,000 107186 Allyl alcohol 1,000 7726956 Bromine 500 107119 Allylamine 500 74839 Bromomethane 1,000 20859738 Aluminum phosphide 500 4170303 2-Butenal 1,000 2763964 5-(Aminomethyl)-3-isoxazolol 500/10,000 123739 2-Butenal, (e)- 1,000 54626 Aminopterin 500/10,000 1306190 Cadmium oxide 100/10,000 504245 4-Aminopyridine 500/10,000 2223930 Cadmium stearate 1,000/10,000 78535 Amiton 500 7778441 Calcium arsenate 500/10,000 3734972 Amiton oxalate 100/10,000 8001352 Camphechlor 500/10,000 7664417 Ammonia 500 8001352 Camphene, octachloro- 500/10,000 300629 Amphetamine 1,000 56257 Cantharidin 100/10,000 62533 Aniline 1,000 51832 Carbachol chloride 500/10,000 88051 Aniline, 2,4,6-trimethyl- 500 Carbamic acid, methyl-, O-(((2,4- 7783702 Antimony pentafluoride 500 dimethyl-1,3-dithiolan-2- 1397940 Antimycin A 1,000/10,000 26419738 yl)methylene)amino)- 100/10,000 86884 ANTU 500/10,000 1563662 Carbofuran 10/10,000 1303282 Arsenic pentoxide 100/10,000 75150 Carbon disulfide 10,000 1327533 Arsenic trioxide 100/10,000 75445 Carbonic dichloride 10 1327533 Arsenous oxide 100/10,000 79221 Carbonochloridic acid, methylester 500 7784341 Arsenous trichloride 500 Carbonochloridic acid, 1-methylethyl 108236 ester 1,000 7784421 Arsine 100 109615 Carbonochloridic acid, propylester 500 2642719 Azinphos-ethyl 100/10,000 786196 Carbophenothion 500 86500 Azinphos-methyl 10/10,000 57749 Chlordane 1,000 151564 Aziridine 500 470906 Chlorfenvinfos 500 75558 Aziridine, 2-methyl 10,000 7782505 Chlorine 100 98873 Benzal chloride 500 24934916 Chlormephos 500 98168 Benzenamine, 3-(trifluoromethyl)- 500 999815 Chlormequat chloride 100/10,000 98055 Benzenearsonic acid 10/10,000 79118 Chloroacetic acid 100/10,000 100141 Benzene, 1-(chloromethyl)-4-nitro- 500/10,000 584849 Benzene, 2,4-diisocyanato-1-methyl- 500 107073 Chloroethanol 500 91087 Benzene, 1,3-diisocyanato-2-methyl- 100 627112 Chloroethyl chloroformate 1,000 108985 Benzenethiol 500 67663 Chloroform 10,000 Benzimidazole, 4,5-dichloro-2- 542881 Chloromethyl ether 100 3615212 (trifluoromethyl)- 500/10,000 107302 Chloromethyl methyl ether 100 98077 Benzoic trichloride 100 3691358 Chlorophacinone 100/10,000 98077 Benzotrichloride 100 542767 3-Chloropropionitrile 1,000 100447 Benzyl chloride 500 1982474 Chloroxuron 500/10,000 140294 Benzyl cyanide 500 21923239 Chlorthiophos 500 Bicyclo[2.2.1]heptane-2-carbonitrile, 10025737 Chromic chloride 1/10,000 5-chloro-6- 10210681 Cobalt carbonyl 10/10,000 ((((methylamino)carbonyl)oxy)imino)- 15271417 ,(1-alpha,2-beta,4-alpha,5-alpha,6E))- 500/10,000 Cobalt, ((2,2'-(1,2- ethanediylbis(nitrilomethylidyne))bis(6 1464535 2,2'-Bioxirane 500 62207765 -fluorophenylato))(2-)-N,N',O,O')- 100/10,000 111444 Bis(2-chloroethyl) ether 10,000 64868 Colchicine 10/10,000 542881 Bis(chloromethyl) ether 100 October 2006 List SARA Title III Extremely Hazardous Substances A-1 SARA Title III EXTREMELY HAZARDOUS SUBSTANCES CAS EHS NAME TPQ* CAS EHS NAME TPQ* 56724 Coumaphos 100/10,000 534521 4,6-Dinitro-o-cresol 10/10,000 5836293 Coumatetralyl 500/10,000 534521 Dinitrocresol 10/10,000 95487 o-Cresol 1,000/10,000 88857 Dinoseb 100/10,000 535897 Crimidine 100/10,000 1420071 Dinoterb 500/10,000 4170303 Crotonaldehyde 1,000 78342 Dioxathion 500 123739 Crotonaldehyde, (E)- 1,000 82666 Diphacinone 10/10,000 12002038 Cupric acetoarsenite 500/10,000 152169 Diphosphoramide, octamethyl- 100 506683 Cyanogen bromide 500/10,000 298044 Disulfoton 500 506785 Cyanogen iodide 1,000/10,000 514738 Dithiazanine iodide 500/10,000 2636262 Cyanophos 1,000 541537 Dithiobiuret 100/10,000 675149 Cyanuric fluoride 100 541537 2,4-Dithiobiuret 100/10,000 108918 Cyclohexanamine 10,000 316427 Emetine, dihydrochloride 1/10,000 Cyclohexane, 1,2,3,4,5,6-hexachloro- 115297 Endosulfan 10/10,000 ,(1.alpha.,2.alpha.,3.beta.,4.alpha.,5. 2778043 Endothion 500/10,000 58899 alpha.,6.beta.)- 1,000/10,000 72208 Endrin 500/10,000 66819 Cycloheximide 100/10,000 106898 Epichlorohydrin 1,000 108918 Cyclohexylamine 10,000 2104645 EPN 100/10,000 17702419 Decaborane(14) 500/10,000 50146 Ergocalciferol 1,000/10,000 8065483 Demeton 500 379793 Ergotamine tartrate 500/10,000 919868 Demeton-S-methyl 500 107153 1,2-Ethanediamine 10,000 10311849 Dialifor 100/10,000 79210 Ethaneperoxoic acid 500 19287457 Diborane 100 1622328 Ethanesulfonyl chloride, 2-chloro- 500 19287457 Diborane(6) 100 505602 Ethane, 1,1'-thiobis[2-chloro- 500 110576 trans-1,4-Dichloro-2-butene 500 Ethanimidothioic acid, N- 110576 trans-1,4-Dichlorobutene 500 16752775 [[methylamino)carbonyl] 500/10,000 111444 Dichloroethyl ether 10,000 10140871 Ethanol, 1,2-dichloro-, acetate 1,000 542881 Dichloromethyl ether 100 563122 Ethion 1,000 149746 Dichloromethylphenylsilane 1,000 13194484 Ethoprop 1,000 696286 Dichlorophenylarsine 500 13194484 Ethoprophos 1,000 62737 Dichlorvos 1,000 538078 Ethylbis(2-chloroethyl)amine 500 141662 Dicrotophos 100 107120 Ethyl cyanide 500 1464535 Diepoxybutane 500 107153 Ethylenediamine 10,000 814493 Diethyl chlorophosphate 500 371620 Ethylene fluorohydrin 10 O,O-Diethyl O-pyrazinyl 151564 Ethyleneimine 500 297972 phosphorothioate 500 75218 Ethylene oxide 1,000 71636 Digitoxin 100/10,000 542905 Ethylthiocyanate 10,000 2238075 Diglycidyl ether 1,000 22224926 Fenamiphos 10/10,000 20830755 Digoxin 10/10,000 115902 Fensulfothion 500 115264 Dimefox 500 4301502 Fluenetil 100/10,000 1,4:5,8-Dimethanonaphthalene, 1,2,3,4,10,10-hexachloro- 7782414 Fluorine 500 1,4,4a,5,8,8a-hexahydro- 640197 Fluoroacetamide 100/10,000 (1.alpha.,4.alpha.,4a.beta.,5.alpha.,8. 144490 Fluoroacetic acid 10/10,000 309002 alpha.,8a.beta.)- 500/10,000 62748 Fluoroacetic acid, sodium salt 10/10,000 60515 Dimethoate 500/10,000 359068 Fluoroacetyl chloride 10 2524030 Dimethyl chlorothiophosphate 500 51218 Fluorouracil 500/10,000 75785 Dimethyldichlorosilane 500 944229 Fonofos 500 57147 1,1-Dimethyl hydrazine 1,000 50000 Formaldehyde 500 57147 Dimethylhydrazine 1,000 107164 Formaldehyde cyanohydrin 1,000 99989 Dimethyl-p-phenylenediamine 10/10,000 23422539 Formetanate hydrochloride 500/10,000 2524030 Dimethyl phosphorochloridothioate 500 2540821 Formothion 100 77781 Dimethyl sulfate 500 17702577 Formparanate 100/10,000 644644 Dimetilan 500/10,000 21548323 Fosthietan 500 88857 Dinitrobutyl phenol 100/10,000 3878191 Fuberidazole 100/10,000 October 2006 List SARA Title III Extremely Hazardous Substances A-2 SARA Title III EXTREMELY HAZARDOUS SUBSTANCES CAS EHS NAME TPQ* CAS EHS NAME TPQ* 110009 Furan 500 542881 Methane, oxybis[chloro- 100 13450903 Gallium trichloride 500/10,000 594423 Methanesulfenyl chloride, trichloro- 500 Hexachlorocyclohexane (gamma 558258 Methanesulfonyl fluoride 1,000 58899 isomer) 1,000/10,000 509148 Methane, tetranitro- 500 77474 Hexachlorocyclopentadiene 100 74931 Methanethiol 500 4835114 Hexamethylenediamine, N,N'-dibutyl- 500 67663 Methane, trichloro- 10,000 302012 Hydrazine 1,000 4,7-Methanoindan, 1,2,3,4,5,6,7,8,8- 57147 Hydrazine, 1,1-dimethyl- 1,000 57749 octachloro-2,3,3a,4,7,7a-hexahydro- 1,000 60344 Hydrazine, methyl- 500 950378 Methidathion 500/10,000 74908 Hydrocyanic acid 100 2032657 Methiocarb 500/10,000 7664393 Hydrofluoric acid 100 16752775 Methomyl 500/10,000 7647010 Hydrogen chloride (gas only) 500 151382 Methoxyethylmercuric acetate 500/10,000 74908 Hydrogen cyanide 100 74839 Methyl bromide 1,000 7664393 Hydrogen fluoride 100 80637 Methyl 2-chloroacrylate 500 7722841 Hydrogen peroxide (Conc.> 52%) 1,000 79221 Methyl chlorocarbonate 500 7783075 Hydrogen selenide 10 79221 Methyl chloroformate 500 7783064 Hydrogen sulfide 500 60344 Methyl hydrazine 500 123319 Hydroquinone 500/10,000 624839 Methyl isocyanate 500 13463406 Iron carbonyl (Fe(CO)5), (TB-5-11)- 100 556616 Methyl isothiocyanate 500 13463406 Iron, pentacarbonyl- 100 75865 2-Methyllactonitrile 1,000 297789 Isobenzan 100/10,000 74931 Methyl mercaptan 500 78820 Isobutyronitrile 1,000 502396 Methylmercuric dicyanamide 500/10,000 Isocyanic acid, 3,4-dichlorophenyl 298000 Methyl parathion 100/10,000 102363 ester 500/10,000 3735237 Methyl phenkapton 500 465736 Isodrin 100/10,000 676971 Methyl phosphonic dichloride 100 55914 Isofluorphate 100 556649 Methyl thiocyanate 10,000 4098719 Isophorone diisocyanate 500 75796 Methyltrichlorosilane 500 108236 Isopropyl chloroformate 1,000 78944 Methyl vinyl ketone 10 Isopropylmethylpyrazolyl 1129415 Metolcarb 100/10,000 119380 dimethylcarbamate 500 7786347 Mevinphos 500 556616 Isothiocyanatomethane 500 315184 Mexacarbate 500/10,000 78977 Lactonitrile 1,000 50077 Mitomycin C 500/10,000 21609905 Leptophos 500/10,000 6923224 Monocrotophos 10/10,000 541253 Lewisite 10 2763964 Muscimol 500/10,000 58899 Lindane 1,000/10,000 505602 Mustard gas 500 7580678 Lithium hydride 100 13463393 Nickel carbonyl 1 109773 Malononitrile 500/10,000
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    EPA Method 538: Determination of Selected Organic Contaminants in Drinking Water with Direct Aqueous Injection LC/MS/MS E. Michael Thurman and Imma Ferrer Center for Environmental Mass Spectrometry University of Colorado Boulder, CO, USA Confidentiality Label 1 March 20, 2012 Abstract EPA Method 538 is a new method from EPA for organophosphate pesticides in drinking water. It uses direct aqueous injection; thus, no sample preparation is needed. We use both UHPLC (Agilent 1290) and MS/MS (Agilent 6460) analysis for rapid analysis and sensitive detection with ng/L limits of detection. A second MRM is added for more reliable identification. Confidentiality Label 2 March 20, 2012 Hypothesis Direct injection of organophosphate pesticides (EPA Method 538) will work by UHPLC (Agilent Model 1290) and LC/MS/MS with Jetstream (Agilent Model 6460) with trace level detection at ng/L concentrations. Confidentiality Label 3 March 20, 2012 1. Introduction-Summary 1.1 EPA Method 538 (published in November 2009 by Shoemaker) deals with Organophosphate pesticides in drinking water (1) and one other contaminant, quinoline. 1.2 The method consists of 10 compounds: acephate, aldicarb, aldicarb sulfoxide, dicrotophos, diisopropylmethylphosphonate (DIMP), fenamiphos sulfone, fenamiphos sulfoxide, methamidophos, oxydemeton methyl, quinoline, and thiofanox with 5 labeled internal standards. 1.3 Direct aqueous injection is used with a large volume sample of 100 microliters; thus, no sample preparation is needed. 1.4 Because solid phase extraction (i.e. concentration of the sample is not carried out) suppression is mimimized in the analysis. 1.5 Part-per-Trillion Detection Limits. Confidentiality Label 4 March 20, 2012 Introduction 1.1: EPA Method 538: Determination of Selected Organic Contaminants in Drinking Water by Direct Aqueous Injection by Jody Shoemaker, EPA Cincinnati, OH [email protected] 513-569-7298 Confidentiality Label 5 March 20, 2012 Introduction: 1.2.
  • Organophosphate Poisoning : a Review

    Organophosphate Poisoning : a Review

    120 Sinha and Sharma Med J Indones Organophosphate poisoning : A review Parmod K. Sinha, Ashok Sharma Abstrak Pestisida organofosfat digunakan secara luas di seluruh dunia. Keracunan oleh bahan ini merupakan masalah kesehatan masyarakat, terutama di negara berkembang. Zat neurotoksik organofosfat merupakan bahan yang dianggap mengancam dalam bidang militer dan terorisme. Mekanisme toksisitas bahan ini adalah dengan cara menghambat asetilkolinesterase yang mengakibatkan menumpuknya neurotransmitor asetilkolin dan terjadi rangsangan terus-menerus pada reseptor asetilkolin pada sistem saraf sentral maupun perifer. Selain krisis kolinergik, organofosfat dapat menimbulkan berbagai sindrom neurologis, baik akut maupun kronik. Sedangkan gejala peralihan ( intermediate) terjadi 1-4 hari setelah krisis kolinergik teratasi. Pengobatan standar terdiri dari reaktivasi asetilkolinesterase dengan antidot golongan oksim (prolidoksim, oksidoksime, HI-6 dan HLo7), dan pengendalian efek biokimia asetilkolin dengan menggunakan atropin. Golongan oksim yang baru HI-6 dan Hlo7 merupakan reaktivator asetilkolinesterase yang lebih cocok dan efektif untuk keracunan akut dan berat dibandingkan dengan prolidoksim dan obidoksim. Penderita yang mendapat pengobatan segera, biasanya dapat sembuh dari toksisitas akut, namun gejala neurologis ikutan dapat saja terjadi. (Med J Indones 2003; 12: 120-6) Abstract Organophosphate pesticides are used extensively worldwide, and poisoning by these agents, particularly in developing nations is a public health problem. Organophosphorous
  • Guide No. 1 – October 2020 2/12 the CONCEPT and IMPLEMENTATION of CPA GUIDANCE RESIDUE LEVELS

    Guide No. 1 – October 2020 2/12 the CONCEPT and IMPLEMENTATION of CPA GUIDANCE RESIDUE LEVELS

    Cooperation Centre for Scientific Research Relative to Tobacco CORESTA GUIDE N° 1 The Concept and Implementation of CPA Guidance Residue Levels October 2020 Agro-Chemical Advisory Committee CORESTA TECHNICAL GUIDE N° 1 Title: The Concept and Implementation of CPA Guidance Residue Levels Status: Valid Note: This document will be periodically reviewed by CORESTA Document history: Date of review Information July 2003 Version 1 GRL for Pyrethrins () and Terbufos corrected. December 2003 CPA terminology corrected. June 2008 Version 2 – GRLs revised and residue definitions added Provisional GRL of 2.00 ppm for Cyfluthrin to replace previous June 2010 GRL of 0.50 ppm July 2013 Version 3 – GRLs revised October 2013 Note for Maleic Hydrazide revised Version 4 – GRLs revised + clarification that scope of GRLs July 2016 applies predominantly to the production of traditional cigarette tobaccos and GAP associated with their cultivation. June 2018 Fluopyram GRL of 5 ppm added to GRL list Version 5 – Nine new CPAs with GRL added to list. November 2019 Revision of GRLs for Chlorantraniliprole and Indoxacarb. Updated web links. October 2020 Version 6 – Flupyradifurone GRL of 21 ppm added to GRL list. CORESTA Guide No. 1 – October 2020 2/12 THE CONCEPT AND IMPLEMENTATION OF CPA GUIDANCE RESIDUE LEVELS Executive Summary • Guidance Residue Levels (GRLs) are in the remit of the Agro-Chemical Advisory Committee (ACAC) of CORESTA. Their development is a joint activity of all ACAC members, who represent the leaf production, processing and manufacturing sectors of the Tobacco Industry. The concept of GRLs and their implementation are described in this guide. • GRLs provide guidance to tobacco growers and assist with interpretation and evaluation of results from analyses of residues of Crop Protection Agents (CPAs*).