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23Rd European Conference on General Thoracic Surgery 23rd European Conference on General Thoracic Surgery 31 May – 3 June 2015 Lisbon Congress Center, Lisbon, Portugal 23rd European Conference on General Thoracic Surgery TABLE OF CONTENTS Sunday, 31 May 2015 Database and Quality Certification Session 5 Monday, 1 June 2015 Session I/ Brompton 10 ESTS Lecture 20 Session II/ Videos I 22 Session III/ Pulmonary Non Neoplastic 28 Session IV/ Pulmonary Neoplastic I 36 Pediatric Congenital Thoracic Malformations Session 49 Session V/ Young Investigators Award 54 ESTS-IASLC Joint Session 69 Biology Club 74 VATS/RATS Session 82 Session VI/ Innovative/Experimental 90 Oscar Night Videos 100 Tuesday, 2 June 2015 ESTS– EACTA Joint Session 106 Session VIII/ Mixed Thoracic I 112 Session IX/ Pulmonary Neoplastic II 129 ESTS – Portuguese - Brazilian Joint Session 141 Session X/ Mixed Thoracic II 146 Session XI/ Videos II 163 Session XII/ Interesting Cases 169 Session XIII/ Esophagus/Mediastinum 173 Session XIV/ Airway/Transplantation 185 Session XV/ Chest Wall/Diaphragm/Pleura 195 ESTS-STS Joint Session 206 Session XVI/ MITIG VATS Session 211 2 Lisbon – Portugal – 2015 TABLE OF CONTENTS Wednesday, 3 June 2015 Session XVII/ Videos III 226 ESTS-CATS Joint Session 232 Posters 239 Nurse Symposium-Oral 410 Nurse Symposium-Posters 426 List of Authors 441 3 23rd European Conference on General Thoracic Surgery ABSTRACTS 4 Abstracts 001 - 002 Lisbon – Portugal – 2015 ABSTRACTS Sunday P.M. SUNDAY, 31 MAY 2015 13:00 - 14:30 DATABASE AND QUALITY CERTIFICATION SESSION F-001 THE IMPACT OF ADJUVANT CHEMOTHERAPY IN ATYPICAL CARCINOID OF THE LUNG. A PROPENSITY SCORE ANALYSIS OF THE EUROPEAN SOCIETY OF THORACIC SURGEONS LUNG NEUROENDOCRINE DATABASE Pier Luigi Filosso1, A. Evangelista2, F. Guerrera1, P. Thomas3, S. Welter4, P. Moreno Casado5, F. Venuta6, E. Rendina7, A. Brunelli8, L. Ampollini9, F. Ardissone10, W. Travis11, M. Nosotti12, D. Sagan13, F. Raveglia14, O. Rena15, S. Margaritora16, I. Sarkaria17, E.S.O.T.S. Lung Neuroendocrine Working Group1 1Thoracic Surgery, University of Turin, Turin, Italy 2Unit of Cancer Epidemiology, CPO Piedmont, Turin, Italy 3Thoracic Surgery North Hospital, APHM - Aix-Marseille University, Marseille, France 4Thoraxchirurgie und Thorakale Endoskopie, Ruhrlandklinik Essen, Essen, Germany 5Thoracic Surgery, University Hospital Reina Sofia, Cordoba, Spain, 6Thoracic Surgery, University of Rome Sapienza, Rome, Italy 7Thoracic Surgery, University of Rome Sapienza, St. Andrea Hospital, Rome, Italy 8Department of Thoracic Surgery, St. James’s University Hospital Bexley Wing, Leeds, United Kingdom 9Department of Surgical Sciences, Thoracic Surgery, University Hospital of Parma, Parma, Italy 10Thoracic Surgery Unit, University of Turin, Orbassano, Italy 11Pathology, Memorial Sloan Kettering cancer Center, New York, United States of America 12Thoracic Surgery And Lung Transplantation, Fondazione Cà Granda Ospedale Maggiore Policlinico, Milan, Italy 13Thoracic Surgery, Medical University of Lublin, Lublin, Poland 14Thoracic Surgery, AO San Paolo, Milan, Italy 15Thoracic Surgery Unit, University of Eastern Piedmont, Novara, Italy 16Department of General Thoracic Surgery, Catholic University, Rome, Italy 17Thoracic Surgery, University of Pittsburgh Schools of the Health Sciences, Pittsburgh, United States of America Objectives: Atypical Carcinoids (ACs) of the lung are uncommon neoplasms with a biological behavior still not entirely understood. The efficacy of adjuvant regimens remains unclear, since these tumors do not seem completely responsive to chemo-radiotherapy. Moreover, local or distant relapses are not unusual in ACs. The aim of this study is to evaluate the impact of adjuvant treatment in resected ACs. 5 23rd European Conference on General Thoracic Surgery ABSTRACTS Methods: This is a retrospective study, including ACs operated between 1992 and 2012, in 17 institutions worldwide. Stage I tumors were excluded from the analysis. Overall survival (OS), calculated from date of resection, was estimated by the Kaplan-Meier method. Propensity Score (PS) for the likelihood of having been submitted to adjuvant chemotherapy (CT) was estimated based on the following variables: age, gender, smoking history, previous malignancy, ECOG Perfor- mance Score (ECOG-PS), pTNM stage, resection status and year of surgery. PS-adjusted and Multivariable-adjusted OS comparisons by adjuvant chemotherapy were assessed using the Cox regression model. Results: Overall, 75 cases were encompassed in the final analysis: 19 (25 %) received adjuvant che- motherapy. The median follow-up (FU) was 51 months; FU completeness was 89 %. At the end of the study, 24 patients died (5 in the CT group). Patients receiving adjuvant-CT showed a slightly better survival (HR 0.80, P= 0.66 Figure 1). PS-adjusted analyses demonstrated no significative effect of adjuvant chemotherapy on OS (adjuvant-CT yes vs no HR: 0.97, 95%CI 0.34- 2.79, P= 0.95, Table 1). Sensitive analysis performed using multivariable Cox model showed similar results (HR 1.06, 95%CI 0.29 -3.76 P= 0.93). Age and advanced pTNM stages were independent predictors. 6 Abstracts 001 - 002 Lisbon – Portugal – 2015 ABSTRACTS Sunday P.M. HR (95%CI) P Adjuvant Chemotherapy YES vs NO (Crude) 0.66. (0.29 to 2.15) 0.501 Adjuvant Chemotherapy YES vs NO (PS adjusted) 0.97 (0.34 to 2.79) 0.95 Adjuvant Chemotherapy YES vs NO (adjusted for the 1.06(0.29 to 3.76) 0.93 below factors) Age (per 1 year increase) 1.06 (1.00 to 1.12) 0.039 Male gender 1.14 (0.42 to 3.15) 0.79 Smoke 2.76 (0.91 to 8.3) 0.072 Previous Malignancy 2.89 (0.86 to 9.66) 0.086 ECOG PS>=2 1.06 (0.93 to 4.01) 0.09 pTNM III vs II 2.06 (0.61 to 6.96) 0.24 IV vs II 8.12 (1.5 to 43.88) 0.015 Resection status (R0 vs R1) 0.75 (0.09 to 6.43) 0.79 Year of Surgery 1999-2005 vs 1992-1998 0.99 (0.21 to 4.77) 0.99 2006-2012 vs 1992-1998 1.12 (0.26 to 4.82) 0.87 Conclusion: Our results did not demonstrate any CT significant advantage on survival in resected ACs. Multi-institutional randomized clinical trials are needed to find optimal treatment for advanced stage tumors. Disclosure: No significant relationships. 7 23rd European Conference on General Thoracic Surgery ABSTRACTS F-002 THE EUROPEAN THORACIC DATA QUALITY PROJECT: COMPOSITE DATA-QUALITY SCORE TO MEASURE QUALITY OF INTERNATIONAL MULTI-INSTITUTIONAL DATABASES Michele Salati1, P-E. Falcoz2, A. Brunelli3 1Thoracic Surgery, Ospedali Riuniti Ancona, Ancona, Italy 2Thoracic Surgery, NHC - Universty of Strasbourg, Strasbourg, France 3Department of Thoracic Surgery, St. James’s University Hospital Bexley Wing, Leeds, United Kingdom Objectives: To describe the methodology for the development of data quality metrics in multi-institution- al databases, deriving a cumulative data quality score (Composite Data-quality Score). The ESTS-database was used to create and apply the metrics. The Units contributing to the ESTS- database were ranked for the quality of data uploaded using the CDS. Methods: We analyzed data obtained from 96 Units contributing with at least 100 major lung resections (January 2007-December 2014). The Units were anonymized assigning a casual numeric code. The following metrics were developed for measuring the data quality of each Unit: • record-cumulative-Completeness (COM); rate of present variables on 16 expected vari- ables for all the records uploaded [1-null values / total expected values, the concept of “null value” was defined for each variable] • record-cumulative-Reliability (REL); rate of consistent checks on 9 checks tested for all the records uploaded [1-inconsistent controls / total possible consistent controls, specific consistency control queries were defined] • These two metrics were rescaled using mean ad standard deviation of the entire dataset and summed, obtaining: • Composite Data-quality Score (CDS): [COM rescaled+REL rescaled], it measures the cu- mulative data quality. • The CDS was used to rank the contributors. Results: As reported in table-1, the COM of ESTS-database contributors varied from 98.59% to 43.03% and the REL from 100% to 86.98. Combining the rescaled metrics, the obtained CDS ranged between 2.67 (highest quality) to -7.85 (lowest quality). Comparing the rating using the COM to the one obtained using the CDS, 93% of Units changed their position. The larger movement was a fall down of 66 position in the list. 8 Abstracts 001 - 002 Lisbon – Portugal – 2015 ABSTRACTS Sunday P.M. Conclusion: We described a reproducible method for data quality assessment in clinical multi-institutional databases. The CDS is a unique indicator able to describe data quality and to compare it among Centers. It has the potential of objectively lead projects of data quality management and im- provement. Disclosure: No significant relationships. 9 23rd European Conference on General Thoracic Surgery ABSTRACTS MONDAY, 1 JUNE 2015 08:30 - 10:30 SESSION I: BROMPTON B-003 ANALYSIS OF THE MOST COMMON MAJOR INTRAOPERATIVE COMPLICATIONS DURING VIDEO-ASSISTED THORACOSCOPIC SURGERY ANATOMICAL RESECTIONS - ON BEHALF OF MINIMALLY INVASIVE THORACIC INTEREST GROUP - EUROPEAN SOCIETY OF THORACIC SURGEONS Herbert Decaluwé1, R.H. Petersen2, H.J. Hansen2, C. Piwkowski3, F. Augustin4, A. Brunelli5, T. Schmid4, K. Papagiannopoulos5, J. Moons1, D. Gossot6 1Thoracic Surgery, University Hospitals Leuven, Leuven, Belgium 2Department of Cardiothoracic Surgery, Rigshospitalet, Copenhagen, Denmark 3Thoracic Surgery, Karol Marcinkowski University of Med Sciences, Poznan, Poland 4Operative Medizin, University of Innsbruck, Innsbruck, Austria 5Department of Thoracic Surgery,
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