Datasheet Inhibitors / / Screening Libraries A DRUG SCREENING EXPERT

Product Name : Frakefamide TFA Catalog Number : T11323 CAS Number : Molecular Formula : C32H35F4N5O7 Molecular Weight : 677.64

Description: Frakefamide is unable to penetrate the blood-brain-barrier and enter the central nervous system. Frakefamide TFA is a potent that acts as a peripheral active μ-selective receptor .

Storage: 2 years -80°C in solvent; 3 years -20°C powder;

Receptor (IC50) Others

In vivo Activity Frakefamide yields a dose dependent increase in appropriate responding to 50% at the highest dose tested (10 μmol/kg) after infusion durations of 2 min, whereas after 15 min infusions a maximum of 25% morphine appropriate responding was occasioned at 17.5 μmol/kg.

Reference 1. Modalen AO, et al. A novel molecule (frakefamide) with peripheral properties: the effects on resting ventilation compared with morphine and placebo. Anesth Analg. 2005 Mar;100(3):713-7. 2. Swedberg MD, et al. Drug discrimination: A versatile tool for characterization of CNS safety pharmacology and potential for drug abuse. J Pharmacol Toxicol Methods. 2016 Sep-Oct;81:295-305.

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