THE FORMER YUGOSLAV REPUBLIC of MACEDONIA Last Updated: 2007-07-24

Vitamin and Mineral Nutrition Information System (VMNIS) WHO Global Database on Iodine Deficiency The database on iodine deficiency includes data by country on goitre prevalence and/or urinary iodine concentration

THE FORMER YUGOSLAV REPUBLIC OF MACEDONIA Last Updated: 2007-07-24

Goitre Urinary iodine (µg/L) Notes prevalence (%) Distribution (%) Prevalence (%) Age Sample Grade Grade TGP <20 20-49 50-99100-299 >300 <100 Median Mean SD Reference General Line Level Date Region and sample descriptor Sex (years) size 1 2 N 2005 National: SAC: Total B 7.00 - 12.99 1200 25.08.7 228.4 238.7 104.3 5328 * 1 SAC by sex F 7.00 - 12.99 584 219.8 230.5 104.0 SAC by sex M 7.00 - 12.99 616 239.6 246.4 104.1 SAC by area: Urban B 7.00 - 12.99 571 240.5 249.3 102.8 SAC by area: Rural B 7.00 - 12.99 529 215.0 225.2 104.7 National: SAC B 7.00 - 12.99 1222 2.1 * N 2003 National: SAC B 7.00 - 12.99 1206 4.7 5396 * N 2002 National: SAC: Total B 7.00 - 11.99 1216 75.9 12.311.8 198.5 206.8 95.8 3609 * 2 SAC by area: Urban B 7.00 - 11.99 803 203 211 92 SAC by area: Rural B 7.00 - 11.99 413 192 199 103 SAC by sex B 7.00 - 11.99 588 190 199 91 SAC by sex B 7.00 - 11.99 628 204 214 99.6 SAC by school: 26 July (Skopje) B 7.00 - 11.99 NS 180.5 SAC by school: Asim Agushi (Radolishta village) B 7.00 - 11.99 NS 229.5 SAC by school: Boris Kidrich (Saraj Village) B 7.00 - 11.99 NS 188.5 SAC by school: Dame Gruev (Kuklish Village) B 7.00 - 11.99 NS 185.5 SAC by school: Dedo Iljo Maleshevski (Berovo) B 7.00 - 11.99 NS 164.5 SAC by school: Dervish Cara (Dolno Palchishte Vi B 7.00 - 11.99 NS 219 SAC by school: Dimo Hadzi Dimov (Skopje) B 7.00 - 11.99 NS 207 SAC by school: Faik Konica (Greshnica Village) B 7.00 - 11.99 NS 202 SAC by school: Goce Delchev (Resen) B 7.00 - 11.99 NS 182.5 SAC by school: Goce Delchev (Vinica) B 7.00 - 11.99 NS 184 SAC by school: Gorgi Pulevski (Skopje) B 7.00 - 11.99 NS 240.5 SAC by school: Gorgi Sugarev (Bitola) B 7.00 - 11.99 NS 221 SAC by school: J.Hadzi-Konstantinov Dzinot (Vele B 7.00 - 11.99 NS 218 SAC by school: Jane Sandanski (Skopje) B 7.00 - 11.99 NS 221 SAC by school: Joakim Krchoski (Kr.Palanka) B 7.00 - 11.99 NS 165.5 SAC by school: Kiril Pejchinovik (Skopje) B 7.00 - 11.99 NS 184 SAC by school: Kliment Ohridski (Prilep) B 7.00 - 11.99 NS 225 SAC by school: Krste Misirkov (Kumanovo) B 7.00 - 11.99 NS 238.5 SAC by school: Manchu Matak (Krivogashtani Vill B 7.00 - 11.99 NS 168 SAC by school: Mosha Pijade (Gostivar) B 7.00 - 11.99 NS 181.5 SAC by school: Naim Frasheri (Kumanovo) B 7.00 - 11.99 NS 192 SAC by school: Naim Frasheri (Renovo) B 7.00 - 11.99 NS 229 SAC by school: Naim Frasheri (Senokos Village) B 7.00 - 11.99 NS 232 SAC by school: Panajot Ginovski (Skopje) B 7.00 - 11.99 NS 221.5

© WHO Global Database on Iodine Deficiency Vitamin and Mineral Nutrition Information System (VMNIS) WHO Global Database on Iodine Deficiency The database on iodine deficiency includes data by country on goitre prevalence and/or urinary iodine concentration

THE FORMER YUGOSLAV REPUBLIC OF MACEDONIA Last Updated: 2007-07-24

Goitre Urinary iodine (µg/L) Notes prevalence (%) Distribution (%) Prevalence (%) Age Sample Grade Grade TGP <20 20-49 50-99100-299 >300 <100 Median Mean SD Reference General Line Level Date Region and sample descriptor Sex (years) size 1 2 N 2002 SAC by school: Pashko Vasa (Grupchin Village) B 7.00 - 11.99 NS 161.5 3609 SAC by school: Riste Risteski (Dolno Kosovrasti V B 7.00 - 11.99 NS 148.5 SAC by school: Sande Masev (Strumica) B 7.00 - 11.99 NS 240.5 SAC by school: Strasho Pindzur (Negotino) B 7.00 - 11.99 NS 190 SAC by school: Tosho Velkov Pepeto (Kavadarci) B 7.00 - 11.99 NS 214.5 SAC by school: Wegosh (Idrizovo Village) B 7.00 - 11.99 NS 201 National: SAC B 7.00 - 11.99 1222 5.8 * N 2001 National: SAC B 8.00 - 10.99 929 16164.5 182.7 91.4 3061a * 3 N 2001 National: PW/LW: Total F NS 490 0.4 4.1 217.6 25.5 140 3061b * 4 Women by physiological status: PW F NS 382 0.5 3.9 20.77.6 25.1 141 5 Women by physiological status: LW F NS 108 0 4.7 22.2 7.4 26.9 139 6 PW by trimester: 1st F NS 78 0 0 21.83.9 21.8 150 7 PW by trimester: 2nd F NS 140 0.7 5.7 17.1 23.6 158 8 PW by trimester: 3rd F NS 164 0.6 4.3 23.2 4.3 28.0 130 9

N 2000 National: SAC B 8.00 - 10.99 1211 19154.1 169 97.1 3061c * 10 National: SAC B 8.00 - 10.99 NS 5.0 * N 1999 National: Women: Total F 15.00 - 45.99 1029 9.3 0.6 9.9 1609 * Women by area: Urban F 15.00 - 45.00 559 8.6 0.9 9.5 Women by area: Rural F 15.00 - 45.00 470 10.4 0.2 10.6

N 1999 National: SAC B 8.00 - 10.99 1142 39116.7 131.9 76.9 3061d * 11 National: SAC B 8.00 - 10.99 NS 13.0 * N 1995 -1996 National: SAC: Total B 6.00 - 15.99 2380 41117 132 3477 * 12 SAC by district: Berovo B 6.00 - 15.99 31 110 SAC by district: Bitola B 6.00 - 15.99 112 114 SAC by district: Debar B 6.00 - 15.99 64 109 SAC by district: Delcevo B 6.00 - 15.99 32 107 SAC by district: Demir Hisar B 6.00 - 15.99 28 152 SAC by district: Gevgelija B 6.00 - 15.99 30 98 SAC by district: Gostivar B 6.00 - 15.99 159 96 SAC by district: Kavadarci B 6.00 - 15.99 45 111 SAC by district: Kicevo B 6.00 - 15.99 61 112 SAC by district: Kocani B 6.00 - 15.99 48 97

THE FORMER YUGOSLAV REPUBLIC OF MACEDONIA Last Updated: 2007-07-24

Goitre Urinary iodine (µg/L) Notes prevalence (%) Distribution (%) Prevalence (%) Age Sample Grade Grade TGP <20 20-49 50-99100-299 >300 <100 Median Mean SD Reference General Line Level Date Region and sample descriptor Sex (years) size 1 2 N 1995 -1996 SAC by district: Kratovo B 6.00 - 15.99 22 113 3477 SAC by district: Kriva Palanka B 6.00 - 15.99 26 103 SAC by district: Krusevo B 6.00 - 15.99 30 124 SAC by district: Kumanovo B 6.00 - 15.99 163 163 SAC by district: Makedon. Brod B 6.00 - 15.99 32 98 SAC by district: Negotino B 6.00 - 15.99 31 136 SAC by district: Ohrid B 6.00 - 15.99 59 81 SAC by district: Prilep B 6.00 - 15.99 96 171 SAC by district: Probistip B 6.00 - 15.99 36 104 SAC by district: Radovis B 6.00 - 15.99 33 110 SAC by district: Resen B 6.00 - 15.99 32 110 SAC by district: Skopje B 6.00 - 15.99 569 125 SAC by district: Stip B 6.00 - 15.99 73 112 SAC by district: Struga B 6.00 - 15.99 123 84 SAC by district: Strumica B 6.00 - 15.99 90 190 SAC by district: Sveti Nikole B 6.00 - 15.99 32 116 SAC by district: Tetovo B 6.00 - 15.99 212 79 SAC by district: Valandovo B 6.00 - 15.99 30 92 SAC by district: Veles B 6.00 - 15.99 64 122 SAC by district: Vinica B 6.00 - 15.99 33 107 National: SAC: Total B 6.00 - 15.99 11486 18.7 * SAC by sex F 6.00 - 15.99 5818 20.8 SAC by sex M 6.00 - 15.99 5688 16.5 SAC by age B 6.00 - 7.99 1356 11.6 SAC by age B 8.00 - 8.99 1394 13.2 SAC by age B 9.00 - 9.99 1483 17.8 SAC by age B 10.00 - 10.99 1520 19.0 SAC by age B 11.00 - 11.99 1550 18.7 SAC by age B 12.00 - 12.99 1492 22.8 SAC by age B 13.00 - 13.99 1449 24.2 SAC by age B 14.00 - 15.99 1279 21.7 SAC by district: Berovo B 6.00 - 15.99 129 7.8 SAC by district: Bitola B 6.00 - 15.99 548 16.8 SAC by district: Debar B 6.00 - 15.99 241 24.9 SAC by district: Delcevo B 6.00 - 15.99 193 11.9 SAC by district: Demir Hisar B 6.00 - 15.99 66 27.3 SAC by district: Gevgelija B 6.00 - 15.99 180 22.2 SAC by district: Gostivar B 6.00 - 15.99 735 21.1

THE FORMER YUGOSLAV REPUBLIC OF MACEDONIA Last Updated: 2007-07-24

Goitre Urinary iodine (µg/L) Notes prevalence (%) Distribution (%) Prevalence (%) Age Sample Grade Grade TGP <20 20-49 50-99100-299 >300 <100 Median Mean SD Reference General Line Level Date Region and sample descriptor Sex (years) size 1 2 N 1995 -1996 SAC by district: Kavadarci B 6.00 - 15.99 271 16.2 3477 SAC by district: Kicevo B 6.00 - 15.99 305 17.5 SAC by district: Kocani B 6.00 - 15.99 282 29.8 SAC by district: Kratovo B 6.00 - 15.99 114 18.4 SAC by district: Kriva Palanka B 6.00 - 15.99 152 13.8 SAC by district: Krusevo B 6.00 - 15.99 127 22.8 SAC by district: Kumanovo B 6.00 - 15.99 862 20.8 SAC by district: Makedon. Brod B 6.00 - 15.99 130 23.1 SAC by district: Negotino B 6.00 - 15.99 183 10.4 SAC by district: Ohrid B 6.00 - 15.99 300 8.0 SAC by district: Prilep B 6.00 - 15.99 441 17.0 SAC by district: Probistip B 6.00 - 15.99 169 24.3 SAC by district: Radovis B 6.00 - 15.99 189 29.6 SAC by district: Resen B 6.00 - 15.99 196 11.7 SAC by district: Skopje B 6.00 - 15.99 2427 15.9 SAC by district: Stip B 6.00 - 15.99 332 25.3 SAC by district: Struga B 6.00 - 15.99 490 13.9 SAC by district: Strumica B 6.00 - 15.99 448 17.2 SAC by district: Sveti Nikole B 6.00 - 15.99 156 24.4 SAC by district: Tetovo B 6.00 - 15.99 1115 19.2 SAC by district: Valandovo B 6.00 - 15.99 188 23.4 SAC by district: Veles B 6.00 - 15.99 388 24.2 SAC by district: Vinica B 6.00 - 15.99 129 28.7

THE FORMER YUGOSLAV REPUBLIC OF MACEDONIA

Reference no 5328 General Notes: Multi-stage cluster sampling with probability proportionate to size; goitre investigated by ultrasonography, values not included in the database.

Line note 1 UI <50 µg/L: 1.5%

Reference no 5396 General Notes: Multi-stage cluster sampling with probability proportionate to size; goitre investigated by ultrasonography, values not included in the database; same data reported in reference No. 5136. Reference no 3609 General Notes: Cluster sampling with probability proportionate to size, 30 schools randomly selected, 10 in rural areas (villages) and 20 in urban areas (towns). Line note 2 UI <50 µg/L: 2.4%

Reference no 3061a General Notes: Cluster survey of school children in 30 randomly selected schools; data provided by University of Kiril and Metodji, Skopje. Line note 3 UI <50 µg/L: 3% Reference no 3061b General Notes: No description of sampling; data provided by University of Kiril and Metodji, Skopje. Line note 4 UI 100-199 µg/L: 51.8%, UI 200-300 µg/L: 15.1% Line note 5 UI 100-199 µg/L: 53.2%, UI 200-300 µg/L: 14.1% Line note 6 UI 100-199 µg/L: 47.2%, UI 200-300 µg/L: 18.5% Line note 7 UI 100-199 µg/L: 60.2%, UI 200-300 µg/L: 14.1% Line note 8 UI 100-199 µg/L: 49.3%, UI 200-300 µg/L: 13.6% Line note 9 UI 100-199 µg/L: 53.0%, UI 200-300 µg/L: 14.6% Reference no 3061c General Notes: Cluster survey of school children in 30 randomly selected schools; data provided by University of Kiril and Metodji, Skopje.

Line note 10 UI <50 µg/L: 3.8%, UI 100-199 µg/L: 53.3%, UI 200-300 µg/L: 21.3% Reference no 1609 General Notes: Two-stage cluster sampling; Multiple Indicator Cluster Survey (MICS).

Reference no 3061d General Notes: Cluster survey of school children in 30 randomly selected schools; data provided by University of Kiril and Metodji, Skopje. Line note 11 UI <50 µg/L: 11% Reference no 3477 General Notes: Cluster survey of school children in 115 randomly selected schools in 30 clusters; goitre investigated by ultrasonography, values not included in the database; urinary iodine measured only for subsample.

Line note 12 UI <50 µg/L: 11%

Reference 1609 Branca F, Pastore G, Rossi L, Sette S, Stojanovska Ancevska B, Janeva N, Kolevska L, Peova S, Muratovska O, Venovska K. Multiple indicator cluster survey in FYR Macedonia with micronutrient component. Rome, National Institute of Nutrition, 2000.

Reference 3061 Karanfilski B. Iodine deficiency in Macedonia [unpublished data]. Skopje, Institute of Pathophysiology and Nuclear Medicine, University Kiril and Meodji, 2001.

Reference 3477 Karanfilski B, Bogdanova V, Vaskova O, Loparska S, Ristevska SM, Shestakov G. Iodine deficiency in the FY Republic of Macedonia (Conditions, consequences and opportunities for prevention). Skopje, United Nations Children's Fund, 1998.

Reference 3609 UNICEF. Report on the activities of the National Committee for iodine deficiency in the year 2002. Skopje, United Nations Children's Fund, 2002.

Reference 5328 Ministry of Health Macedonia. Report on the activities implemented by the National Committee for Iodine Deficiency for 2005. Macedonia, 2005.

Reference 5396 National Iodine Deficiency Committee of Macedonia. Annual report of National Iodine Deficiency Committee 2003. Macedonia, National Iodine Deficiency Committee, 2003.

Reference 3044 Karanfilski B, Bogdanova V, Vaskova O, Loparska S, Miceva-Ristevska S, Sestakov G, Kuzmanovska S, Kolevska L. Correction of iodine deficiency in Macedonia. Journal of Pediatric Endocrinology & Metabolism, 2003, 16 :1041-1045.

Reference 5136 Karanfilski B, Bogdanova V, Vaskova O, Loparska S, Miceva-Ristevska S, Shestakov G, Kuzmanovska S. The correction of iodine deficiency in FYR Macedonia. Skopje, UNICEF, 2004.

Reference 5406 Vitti P, Bürgi H, Kaaskooper K, Baker C. External review of progress in Macedonia towards sustainable optimal iodine nutrition, Macedonia, 19-23 May 2003. Former Yugoslav Republic of Macedonia, Network for Sustained Elimination of Iodine Deficiency, 2003.