MICHAEL ELOWITZ Curriculum Vitae, August 2020

HHMI/ Institute of Technology Broad Center, M/C 114-96 1200 E. California Blvd. Pasadena, CA 91125 Tel: 626-395-8871, Fax: 626-395-5972 email: [email protected], web: http://elowitz.caltech.edu/, twitter: @ElowitzLab Administrative contact: Jo Leonardo, [email protected]

Education & Experience:

2014-present Executive Officer for Bioengineering, Division of Biology and Biological Engineering, Caltech

2010-present Professor of Biology, Bioengineering, and Applied Physics; Bren Scholar California Institute of Technology

2008-present Investigator, Howard Hughes Medical Institute

2008-present Assistant Adjunct Professor, Department of Biological Chemistry, David Geffen School of Medicine at UCLA

2009-2010 Associate Professor of Biology, Bioengineering, and Applied Physics; Bren Scholar, California Institute of Technology

2003-2009 Assistant Professor of Biology and Applied Physics, and Bren Scholar California Institute of Technology

2000-2003 Fellow, Rockefeller University, lab of Arnold J. Levine and Center for Studies in Physics and Biology

1999-2000 Postdoctoral Research, , lab of Stanislas Leibler

1993-1999 Ph.D., Physics, Princeton University, 1999; M.A, Physics, Princeton University, 1997 Advisor: Stanislas Leibler.

1992 NSF Undergraduate Research Fellowship Dept. of Physics, University of Michigan, Advisor: B. Orr

1988-1992 B.A., Physics, University of California, Berkeley Regent's Scholarship & Dean's List, UC Berkeley

Honors and awards:

• The Raymond and Beverly Sackler International prize in Biophysics (2019) • Elected, European Molecular Biology Organization, EMBO (2016) • Fellow, American Academy for the Advancement of Science, AAAS (2016) • Sackler Scholar, Tel Aviv University (2015-2016) Elowitz, Michael B., Page 2

• Elected, American Academy of Arts & Sciences (2015) • Allen Distinguished Investigator (2014) • Israel Pollak Distinguished Lecturer, Technion-Israel Institute of Technology (Dec. 2014) • HFSP Nakasone Award (2011) • Pierre Gilles de Gennes Fellowship (2010) • Presidential Early Career Award in Science and Engineering (2008) • Discover Magazine “Top 20 under 40” (2008) • HHMI Investigator (2008) • MacArthur Fellow (2007) • Packard Fellow (2006) • Searle Scholars Award (2004) • Technology Review magazine TR100 list of top innovators (2004) • Burroughs Wellcome Career Award at the Scientific Interface (2002-2007)

Professional activities:

• Co-Director, Allen Discovery Center for Cell Lineage Tracing (2017-present) • Scientific Advisory Board, Allen Institute (2018-present) • Editorial Board, Cell Systems (2018-present) • Scientific Advisory Board, Freiedrich Miescher-Institute (2017) • Advisor, Biodesign Challenge Team at SCI-ARC and CalArts (2016-2018) • Co-organizer, BIRS Workshop on Principles of Gene Circuit Design, Oaxaca (2017) • Scientific Advisory Board Member, Allen Institute for Cell Science (2014-present) • Advisory Council, Allen Institute for Brain Research Cell Networks (2010-present) • Advisory Board, Kavli Institute for Theoretical Physics (2010-2012) • Associate Editor and then Editorial Advisory Board member, ACS Synthetic Biology (2012-present) • Planning commmittee, Six Party Symposia on Synthetic Biology, through the U.S., U.K., and China National Academies of Science and Engineering (2012-2013). • Scientific Advisor, Warwick Centre for Integrative Synthetic Biology (2013-present) • Advisory Committee, Sloan Foundation Synthetic Biology (2009-2013) • Scientific Advisory Board, SynBERC (2008-2013) • Board of Reviewing Editors, Science (2009-2011). • Editorial Advisory Board, Molecular Systems Biology (2005-present) • Editorial Board, BMC Systems Biology (2006-present) • Steering Committee, NAKFI Synthetic Biology (2009) • Steering Committee, NAKFI Signaling (2003)

Education and outreach:

• Co-developed course “Design Principles of Biological Circuits” at Caltech for undergraduates and graduate students: http://be150.caltech.edu/2020/ • Central Asia Nobel Fest 2020; Discussion with Michael Sheetz, Don Cleveland, and Jeanette Kunz (2020): https://nobel-fest.inpolicy.net/4f-en.html • Science journal for teens: Can we write biological “software updates” to cure disease (2019): https://www.sciencejournalforkids.org/wp-content/uploads/2019/09/protein_article.pdf • Advisor, Biodesign Challenge teams at CalArts and Sci-Arc, 2015-present.

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• Instructor, Advanced School Of Quantitative Biology on “Microbial Strategies for Survival and Evolution,” KITP, UCSB, 2014. • “Life at the single-cell level”. KITP (UCSB) workshop for high school science teachers (2011). • Participant in film ‘Soft Science: Cinema of Attractions,” (Rachel Mayeri, 2003, http://bit.ly/1mcpUxM). Contributed time-lapse movies and partipated in panel discussion.

Formally Supervised Trainees: Postdoctoral Fellows • Georg Seelig, Associate Professor, University of Washington (2003-2009) • Avigdor Eldar, Senior Lectuer, Tel-Aviv University (2004-2009) • David Sprinzak, Principal Investigator, Tel-Aviv University (2004-2010) • Long Cai, Professor, Caltech( 2006-2010) • James Locke, Research Group Leader, University of Cambridge (2006-2012) • Chiraj Dalal, Scientist, Achaogen (2009-2010) • Hao Yuan Kueh, Assistant Professor, University of Washington (2009-2016) • Yaron Antebi, Senior Scientist, Weizmann Institute of Science (2010-2018) • Lacramioara Bintu, Assistant Professor, Stanford University (2011-2016) • Yihan Lin, Assistant Professor, Peking University (2011-2016) • Adam Rosenthal, Senior PI, Dupont (2011-2016) • Fangyuan Ding, Assistant Professor, UC Irvine (2012-2020) • Joseph Levine, Freelance Consultant (2012-2014) • Mark Budde, Senior Postdoctoral Scholar (2013-present) • Emily Capra, Associate, McKinsey & Campany (2013-2017) • Pulin Li, Assistant Professor, MIT (2013-2019) • Joseph Markson, Consultant, Boston Consulting Group (2013-2018) • Kirsten Frieda, COO, Spatial Genomics (2014-2019) • Xiaojing Gao, Assistant Professor, Stanford Univerisity (2015-2019) • Sahand Hormoz, Assistant Professor, Harvard Medical School (2015-2017) • Amjad Askary, Postdoctoral Fellow (2016-present) • Nicolas Pelaez, Postdoctoral Fellow (2016-present) • Laurent Potvin-Trottier, Assistant Professor, Concordia University, Montreal (2017-2018) • Alejandro Granados, Postdoctoral Fellow (2018-present) • Zibo Chen, Postdoctoral Fellow (2019 – present) • Felix Horns, Postdoctoral Fellow (2019 – present) • Akanksha Thawani, Postdoctoral Fellow (2020-Present)

Pre-doctoral Students • Sydney Cox, (2003-2007) • Chiraj Dalal, (2004-2009) • Shaunak Sen (2004-2011) • Joseph Levine (2005-2012) • Lauren LeBon (2007-2014) • Jonathan Young (2007-2013) • Amit Lakhanpal (2008-2013) • Fred Tan (2008-2014)

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• John Yong (2008-2015) • Nagarajan Nandagopal (2009-2018) • Zak Singer (2009-2015) • Jin Park (2011-2017) • Ke-Huan Chow (2014-present) • Heidi Klumpe (2015-present) • Sheng Wang (2015-present) • Yitong Ma (2016-present) • Christina Su (2016-present) • Ronghui Zhu (2016-present) • Lucy Chong (2017-present) • Rachael Kuintzle (2017-present) • Duncan Chadly (2018-present) • Michael Flynn (2018-present) • Jan Gregrowicz (2018-present) • Matthew Langely (2019 – present)

Patents:

U.S. Patent 10,527,631 “Compositions and methods for programmable sensing and control through combinatorial molecular interactions” January 7, 2020

Publications:

I. Preprints

1. Flynn MJ, Snitser O, Flynn J, Green S, Yelin I, Szwarcwort-Cohen M, Kishony R, Elowitz MB, A simple direct RT-LAMP SARS-CoV-2 saliva diagnostic, medRxiv, https://www.medrxiv.org/content/10.1101/2020.11.19.20234948v1 (2020).

2. Chow KHK, Budde MW, Granados AA, Cabrera M, Yoon S, Cho S, Huang T, Koulena N, Frieda KL, Cai L, Lois C, Elowitz MB. Imaging cell lineage with a synthetic digital recording system. BioRXiv (2020) doi: https://doi.org/10.1101/2020.02.21.958678. NIHMSID: 1592729

3. Ding F and Elowitz MB. Dynamics and functional roles of splicing factor autoregulation. BioRXiv (2020) doi: https://doi.org/10.1101/2020.07.22.216887

4. Gao XJ, Chong LS, Ince MH, Kim MS, Elowitz MB. Engineering multiple levels of specificity in an RNA viral vector. BioRXiv (2020) doi: https://doi.org/10.1101/2020.05.27.1199

II. Refereed research papers: (for reviews & commentary pieces, see below)

1. Askary A, Sanchez-Guardado L, Linton JM, Chadly DM, Budde MW, Cai L, Lois C, Elowitz, MB. In situ readout of DNA barcodes and single base edits facilitated by in vitro transcription. Nat Biotechnol (2020) Jan;38(1):66-75.

2. Ding F and Elowitz MB. Constitutive splicing and economies of scale in gene expression. Nat. Struct. Mol. Biol. (2019). Jun;26(6):424-432. doi: 10.1038/s41594-019-0226-x.

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3. Nandagopal N,* Santat LA*, Elowitz MB. Cis-activation in the Notch signaling pathway. eLife (2019) e37880. Doi: 10.7554/eFlife.37880 [*equal contribution].

4. Martinez-Corral R, Raimundez E, Lin Y, Elowitz MB, Garcia-Ojalvo J. Self-Amplifying Pulsatile Protein Dynamics without Positive Feedback. Cell Systems (2018). Oct 24;7(4):453-62

5. Gao XJ, Chong LS, Kim, MS, Elowitz MB. Programmable protein circuits in living cells. Science (2018). Sep 21;361(6408):1252-1258

6. Ng KNK, Yui MA, Mehta A, Siu S, Irwin B, Pease S, Hirose S, Elowitz MB†, Rothenberg EV†, Kueh HY†, A stochastic epigenetic switch controls the dynamics of the T-cell lineage commitment. eLife (2018) Nov 7:e37851 (†co-corresponding author). 7. Nandagopal N, Santat LA, Elowitz MB, “Cis-activation in the Notch signaling pathway,” eLife (2018) bioRxiv 8. Rosenthal AZ, Qi Y, Hormoz S, Park J, LiSH, Elowitz MB. “Metabolic interactions between dynamic bacterial subpopulations,” eLife (2018) May29;7 9. Li P, Markson JS, Wang S, Chen S, Vachharajani V, Elowitz MB, “Morphogen gradient reconstitution reveals Hedgehog pathway design principles,” Science (2018) May4;360

10. Park J, Dies M, Hormoz S, Smith-Unna SE, Quinodoz S, Hernández-Jiménez MJ, Garcia-Ojalvo J, Locke JCW, Elowitz MB, “Molecular time-sharing through dynamic pulsing in single cells.” Cell Systems (2018). Feb 28;6(2):216-229.e15. doi: 10.1016/j.cels.2018.01.011. Epub 2018 Feb 14

11. Nandagopal N, Santat LA, LeBon L, Sprinzak D, Bronner ME, Elowitz MB, “Dynamic ligand discrimination in the Notch signaling pathway”, Cell (2018) Feb 8;172(4):869-880.e19. doi: 10.1016/j.cell.2018.01.002. Epub 2018 Feb 1.

12. Antebi YE, Linton JM, Klumpe H, Bintu B, Gong M, Su C, McCardell R, Elowitz MB “Combinatorial signal perception in the BMP pathway”, Cell (2017) Sep 7;170(6):1184-1196.e24. doi: 10.1016/j.cell.2017.08.015.

13. Frieda KL, Linton JM, Hormoz S, Choi J, Chow KK, Singer ZS, Budde MW, Elowitz MB*, Cai L*, “Synthetic recording and in situ readout of lineage information in single cells”, Nature. (2017; online 2016). Jan 5;541(7635):107-111. doi: 10.1038/nature20777. Epub 2016 Nov 21. *co- corresponding authors.

14. Hormoz S, Singer ZS, Linton JM, Antebi YE, Shraiman BI, Elowitz MB, “Inferring cell state transition dynamics from lineage trees and endpoint single-cell measurements”, Cell Systems. (2016) Nov 23;3(5):419-433

15. Kueh HY, Yui MA, Ng KK, Pease SS, Zhang JA, Damle SS, Freedman G, Siiu S, Bernstein ID, Elowitz MB, Rothenberg EV, “Asynchronous combinatorial action of four regulatory factors activated Bcl11b for T cell commitment”, Nat Immunology. (2016) Oct 12;538(7626):462-463

16. Bintu L, Yong J, Antebi, YE, McCue K, Kazuki Y, Uno N, Oshimura M, Elowitz MB, “Dynamics of epigenetic regulation at the single-cell level,” Science. (2015) Feb 351(6274):720-724

17. Lin Y, Sohn CH, Dalal CK, Cai L, Elowitz MB. “Combinatorial gene regulation by modulation of relative pulse timing,” Nature (2015) Nov 5;527(7576):54-58.

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18. Kim DH, Marinov GK, Pepke S, Singer ZS, He P, Williams B, Schroth GP, Elowitz MB, Wold BJ. “Single-cell transcriptome analysis reveals dynamic changes in lncRMA expression during reprogramming,” Cell Stem Cell. (2015) Jan 8;16(1):88-101

19. Levine, J, Elowitz, MB,“Polyphasic feedback enables tunable cellular timers,” Current Biology (2014) Oct 20;24(20):R994-5. PMCID: PMC4451454

20. LeBon L, Lee TV, Jafar-Nejad H, Sprinzak D, Elowitz MB. “Fringe proteins modulate Notch- ligand Cis and trans interactions to specify signaling states.” (2014) eLife Sep25;3

21. Dalal CK, Cai L, Lin Y, Rahbar K, Elowitz MB. “Pulsatile dynamics in the yeast proteome” Current Biology (2014) Jul;24(18):2189-2194. NIHMSID 627456 PMCID: PMC4203654

22. Singer ZS, Yong J, Tischler J, Hackett JA, Altinok A, Surani MA, Cai L, Elowitz MB. “Dynamic heterogeneity and DNA methylation in embryonic stem cells.” Mol Cell (2014) July 17;55(2): 319-331. PMCID: PMC4104113 23. Tan FE, Elowitz MB, “Brf1 posttranscriptionally regulates pluripotency and differentiation responses downstream of Erk MAP kinase,” PNAS 2014, Apr 29;111(17):E1740-8. doi: 10.1073/pnas.1320873111. 24. Kueh HY, Champhekhar A, Nutt SL, Elowitz MB, Rothenberg EV, “Positive feedback between PU.1 and the cell cycle controls myeloid differentiation,” Science. 2013 Aug 9;341(6146):670-3. doi: 10.1126/science.1240831. PMID: 23868921 25. Young JW, Locke JC, Elowitz MB, “Rate of environmental change determines stress response specificity.” Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4140-5 26. Levine JH, Fontes ME, Dworkin J, Elowitz MB, “Pulsed feedback defers cellular differentiation.” PLoS Biol. 2012 Jan;10(1):e1001252. 27. Young JW, Locke JC, Altinok A, Rosenfeld N, Bacarian T, Swain PS, Mjolsness E, Elowitz MB. “Measuring single-cell gene expression dynamics in bacteria using fluorescence time-lapse microscopy,” Nat Protoc. 2011 Dec 15; 7(1):80-8. Doi: 10.1038/nprot.2011.432. PMID: 22179594 28. Locke JC, Young JW, Fontes M, Hernández Jiménez MJ, Elowitz MB, “Stochastic pulse regulation in bacterial stress response,” Science. 2011 Oct 21; 334(6054):366-9. Epub 2011 Oct 6. PMID: 21979936 29. Sen S, Garcia-Ojalvo J, Elowitz MB. “Dynamical consequences of bandpass feedback loops in a bacterial phosphorelay,” PLoS One. 2011: 6(9):e25102. Epub 2011 Sep 29. PMID: 21980382 30. Zheng G, Lee SA, Antebi Y, Elowitz MB, Yang C. “The ePetri dish, an on-chip cell imaging platform based on subpixel perspective sweeping microscopy (SPSM),” Proc Natl Acad Sci USA. 2011 Oct 11; 108(41):16889-94. Epub 2011 Oct 3. PMID: 21969539 31. Sprinzak D, Lakhanpal A, LeBon L, Garcia-Ojalvo J, Elowitz MB. ”Mutual Inactivation of Notch Receptors and Ligands Facilitates Developmental Patterning,” PLoS Comp. Bio. 2011 June; 7(6) e1002069. 32. Acar M, Pando BF, Arnold FH, Elowitz MB, van Oudenaarden A. “A general mechanism for network-dosage compensation in gene circuits,” Science (2010) Sep 24;329(5999):1656-60. PMID: 20929850 33. Cox RS III, Dunlop MJ, Elowitz MB. “A synthetic three-color scaffold for monitoring genetic regulation and noise,” J Biol Eng. 2010 Jul 21;4:10. PMID: 20646328

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34. Sprinzak D, Lakhanpal A, LeBon L, Santat LA, Fontes ME, Anderson GA, Garcia-Ojalvo J, Elowitz MB. Cis-interactions between Notch and Delta generate mutually exclusive signalling states, Nature, 2010. 35. Çagatay T, Turcotte M, Elowitz MB, Garcia-Ojalvo J, Süel GM, Architecture-Dependent Noise Discriminates Functionally Analogous Differentiation Circuits, Cell. 2009 36. Eldar A, Chary VK, Xenopoulos P, Fontes ME, Loson OC, Dworkin J, Piggot PJ & Elowitz MB. “Partial penetrance facilitates developmental evolution in bacteria,” Nature (2009) July. 37. Dunlop MJ, Cox RS III, Levine JH, Murray RM, Elowitz MB. “ Regulatory activity revealed by dynamic correlations in gene expression noise,” Nature Genetics (2008) 40:1493-1498. 38. Cai L, Dalal CK, Elowitz MB, “Frequency-modulated nuclear localization bursts coordinate gene regulation,” Nature (2008) Sep 25;455(7212):485-490. 39. Presser A, Elowitz MB, Kellis M, Kishony R, “The evolutionary dynamics of the Saccharomyces cerevisiae protein interaction network after duplication,” Proc. Natl. Acad. Sci. (2008) Jan 16; 105(3):950-954. 40. Cox III RS, Surette MG, Elowitz MB, “Programming gene expression with combinatorial promoters,” Mol. Syst. Bio. (2007). Nov 13; 3:145. 41. Rosenfeld N, Young JW, Alon U, Swain PS, Elowitz MB, “Accurate prediction of gene feedback circuit behavior from component properties,” Mol. Syst. Biol. (2007). Nov 13; 3:143. 42. Suel GM, Kulkarni RP, Dworkin J, Garcia-Ojalvo J, Elowitz MB, “Tunability and noise dependence in differentiation dynamics,” Science (2007). Mar 23;315(5819):1716-9. 43. Rosenfeld N, Perkins TJ, Alon U, Elowitz MB, Swain PS, “A fluctuation method to quantify in vivo fluorescence data” (2006) Biophys. J. Jul 15;91(2):759-66 44. Suel GM, Garcia-Ojalvo J, Liberman LM, Elowitz MB, “An excitable gene regulatory circuit induces transient cellular differentiation.”, Nature (2006): 440(7083):545-50. 45. Rosenfeld N, Young JW, Alon U, Swain PS, Elowitz MB, “Gene regulation at the single-cell level,” Science (2005): 307:1962-5. 46. Garcia-Ojalvo J, Elowitz MB, Strogatz SH, “Modeling a synthetic multicellular clock: repressilators coupled by quorum sensing,” PNAS (2004) 101:10955-60. 47. Lahav G, Rosenfeld N, Sigal A, Geva-Zatorsky N, Levine AJ, Elowitz MB, Alon U, “Dynamics of the p53-Mdm2 feedback loop in individual cells,” Nat. Genet. (2004), 36:147-50. 48. Overholtzer M, Rao PH, Favis R, Lu XY, Elowitz MB, Barany F, Landanyi M, Gorlick R, Levine AJ, “The presence of p53 mutations in human osteosarcomas correlates with high levels of genomic instability. Proc Natl Acad Sci (2003) Nov 25;100(24):14511 49. Elowitz MB, Levine AJ, Siggia ED, Swain PS, “Stochastic Gene Expression in a Single Cell,” Science (2002), 297(5584): 1183-6. 50. Swain PS, Elowitz MB, Siggia ED, “Intrinsic and Extrinsic Contributions to Stochasticity in Gene Expression,” (2002), PNAS 99(20): 12795-800. 51. Guet C, Elowitz MB, Hsing W, Leibler S, “Combinatorial synthesis of genetic networks,” Science (2002), 296(5572): 1466-70. 52. Rosenfeld N, Elowitz MB, Alon U, “Negative autoregulation speeds the response times of transcription networks,” J. Mol. Biol. (2002), 323(5): 785-93. 53. Elowitz MB & Leibler S, “A synthetic oscillatory network of transcriptional regulators,” Nature (2000), 403(6767): 335-338.

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54. Elowitz MB, Surette MG, Wolf PE, Stock JB, Leibler S, “Protein mobility in the cytoplasm of Escherichia coli,” J. Bacteriol. (1999), 181(1), 197-203. 55. Surrey T, Elowitz MB, Wolf PE, Yang F, Nedelec F, Shokat K, Leibler S, “Chromophore-assisted light inactivation and self-organization of microtubules and motors,” PNAS (1998), 95(8), 4293- 8. 56. Elowitz MB, Surette MG, Wolf PE, Stock J, Leibler S, “Photoactivation turns green fluorescent protein red,” Curr. Biol. (1997), 7(10), 809-12. 57. Bourdieu L, Duke T, Elowitz MB, Winkelmann DA, Leibler S, Libchaber A, “Spiral Defects in Motility Assays: A Measure of Motor Protein Force,” Phys. Rev. Lett. (1995), 75(1), 176-179.Süel G, Garcia-Ojalvo J, Liberman L, Elowitz MB, “An excitable gene regulatory circuit induces transient cellular differentiation,” (2006) Nature, 440: 545-50. 58. Sudijono J, Johnson MD, Elowitz MB, Snyder CW, Orr BG, “An STM study of molecular-beam epitaxy growth of GaAs,” Surf. Sci. (1993), 280(3), 247-257 59. Sudijono J, Johnson MD, Snyder CW, Elowitz MB, Orr BG, “Surface evolution during molecular-beam epitaxy deposition of GaAs”, Phys. Rev. Lett. (1992), 69(19), 2811-2814.

III. Review articles and commentary:

60. Li P, and Elowitz MB. “Communication codes in developmental signaling pathways”, Development (2019), Jun 27;146(12)

61. Antebi YE, Nandagopal N, Elowitz MB “An operational view of intercellular signaling pathways”, Current Opinion in Systems Biology (2017) Feb;1;16-24 62. Cai L, Elowitz MB, “Principles of Systems Biology”, Cell Systems. (2017) Jan 21 63. Gao XJ, Elowitz MB, “Synthetic biology: Precision timing in a cell”, Nature. (2016) Oct 12 64. Lin Y, Elowitz MB, “Central Dogma Goes Digital”, Mol. Cell (2016) Mar 17:61(6):79102 65. Markson J, Elowitz MB, “Synthetic biology of multicellular systems: new platforms and applications for animal cells and organisms,” ACS Synth Biol. (2014) Dec 19;3(12):875-6 66. Church GM, Elowitz MB, Smolke CD, Voigt CA, Weiss R, “Realizing the potential of synthetic biology,” Nat Rev Mol Cell Biol. (2 014) Apr;15(4):289-94. doi: 10.1038/nrm3767 67. Levine JH, Lin Y, Elowitz MB, “Functional Roles of Pulsing in Genetic Circuits,” Science. (2013) Dec 6;342(6163):1193-200. doi: 10.1126/science.1239999. PMID: 24311681 68. Nandagopal N, Elowitz MB. “Synthetic Biology: Integrated Gene Circuits,” Science. (2011) Sep 2; 333(6047):1244-8. Review. PMID: 21885772 69. Young JW, Elowitz MB. “Mixed messages: how bacteria resolve conflicting signals,” Mol. Cell. (2011) May 20;42(4):405–6. PMID: 21596304 70. Rosenthal AZ, Elowitz MB. “Following evolution of bacterial antibiotic resistance in real time,” Nature Genetics (2011) Dec 27; 44(1):11-3. doi: 10.1038/ng.1048. PMID: 22200772 71. Eldar A, Elowitz MB., Functional roles for noise in genetic circuits, Nature (2010) Sep 9;467(7312):167-73 72. Elowitz MB, Lim WA. “Build life to understand it,” Nature 2010 Dec;468(7326):889–890 73. Locke JCW, Elowitz MB. “Using movies to analyse gene circuit dynamics in single cells,” Nat Rev Micro. (2009) May;7(5):383-392.

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74. Eldar A, Elowitz M, “Systems biology: deviations in mating,” Nature (2005) Sep 25: 437(7059): 631-2. 75. Sprinzak D, Elowitz MB, “Reconstruction of genetic circuits,” Nature (2005) 438:443-8.

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