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MICHAEL ELOWITZ Curriculum Vitae, August 2020 HHMI/California

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MICHAEL ELOWITZ Curriculum Vitae, August 2020 HHMI/California MICHAEL ELOWITZ Curriculum Vitae, August 2020 HHMI/California Institute of Technology Broad Center, M/C 114-96 1200 E. California Blvd. Pasadena, CA 91125 Tel: 626-395-8871, Fax: 626-395-5972 email: [email protected], web: http://elowitz.caltech.edu/, twitter: @ElowitzLab Administrative contact: Jo Leonardo, [email protected] Education & Experience: 2014-present Executive Officer for Bioengineering, Division of Biology and Biological Engineering, Caltech 2010-present Professor of Biology, Bioengineering, and Applied Physics; Bren Scholar California Institute of Technology 2008-present Investigator, Howard Hughes Medical Institute 2008-present Assistant Adjunct Professor, Department of Biological Chemistry, David Geffen School of Medicine at UCLA 2009-2010 Associate Professor of Biology, Bioengineering, and Applied Physics; Bren Scholar, California Institute of Technology 2003-2009 Assistant Professor of Biology and Applied Physics, and Bren Scholar California Institute of Technology 2000-2003 Fellow, Rockefeller University, lab of Arnold J. Levine and Center for Studies in Physics and Biology 1999-2000 Postdoctoral Research, Princeton University, lab of Stanislas Leibler 1993-1999 Ph.D., Physics, Princeton University, 1999; M.A, Physics, Princeton University, 1997 Advisor: Stanislas Leibler. 1992 NSF Undergraduate Research Fellowship Dept. of Physics, University of Michigan, Advisor: B. Orr 1988-1992 B.A., Physics, University of California, Berkeley Regent's Scholarship & Dean's List, UC Berkeley Honors and awards: • The Raymond and Beverly Sackler International prize in Biophysics (2019) • Elected, European Molecular Biology Organization, EMBO (2016) • Fellow, American Academy for the Advancement of Science, AAAS (2016) • Sackler Scholar, Tel Aviv University (2015-2016) Elowitz, Michael B., Page 2 • Elected, American Academy of Arts & Sciences (2015) • Allen Distinguished Investigator (2014) • Israel Pollak Distinguished Lecturer, Technion-Israel Institute of Technology (Dec. 2014) • HFSP Nakasone Award (2011) • Pierre Gilles de Gennes Fellowship (2010) • Presidential Early Career Award in Science and Engineering (2008) • Discover Magazine “Top 20 under 40” (2008) • HHMI Investigator (2008) • MacArthur Fellow (2007) • Packard Fellow (2006) • Searle Scholars Award (2004) • Technology Review magazine TR100 list of top innovators (2004) • Burroughs Wellcome Career Award at the Scientific Interface (2002-2007) Professional activities: • Co-Director, Allen Discovery Center for Cell Lineage Tracing (2017-present) • Scientific Advisory Board, Allen Institute (2018-present) • Editorial Board, Cell Systems (2018-present) • Scientific Advisory Board, Freiedrich Miescher-Institute (2017) • Advisor, Biodesign Challenge Team at SCI-ARC and CalArts (2016-2018) • Co-organizer, BIRS Workshop on Principles of Gene Circuit Design, Oaxaca (2017) • Scientific Advisory Board Member, Allen Institute for Cell Science (2014-present) • Advisory Council, Allen Institute for Brain Research Cell Networks (2010-present) • Advisory Board, Kavli Institute for Theoretical Physics (2010-2012) • Associate Editor and then Editorial Advisory Board member, ACS Synthetic Biology (2012-present) • Planning commmittee, Six Party Symposia on Synthetic Biology, through the U.S., U.K., and China National Academies of Science and Engineering (2012-2013). • Scientific Advisor, Warwick Centre for Integrative Synthetic Biology (2013-present) • Advisory Committee, Sloan Foundation Synthetic Biology (2009-2013) • Scientific Advisory Board, SynBERC (2008-2013) • Board of Reviewing Editors, Science (2009-2011). • Editorial Advisory Board, Molecular Systems Biology (2005-present) • Editorial Board, BMC Systems Biology (2006-present) • Steering Committee, NAKFI Synthetic Biology (2009) • Steering Committee, NAKFI Signaling (2003) Education and outreach: • Co-developed course “Design Principles of Biological Circuits” at Caltech for undergraduates and graduate students: http://be150.caltech.edu/2020/ • Central Asia Nobel Fest 2020; Discussion with Michael Sheetz, Don Cleveland, and Jeanette Kunz (2020): https://nobel-fest.inpolicy.net/4f-en.html • Science journal for teens: Can we write biological “software updates” to cure disease (2019): https://www.sciencejournalforkids.org/wp-content/uploads/2019/09/protein_article.pdf • Advisor, Biodesign Challenge teams at CalArts and Sci-Arc, 2015-present. 2 Elowitz, Michael B., Page 3 • Instructor, Advanced School Of Quantitative Biology on “Microbial Strategies for Survival and Evolution,” KITP, UCSB, 2014. • “Life at the single-cell level”. KITP (UCSB) workshop for high school science teachers (2011). • Participant in film ‘Soft Science: Cinema of Attractions,” (Rachel Mayeri, 2003, http://bit.ly/1mcpUxM). Contributed time-lapse movies and partipated in panel discussion. Formally Supervised Trainees: Postdoctoral Fellows • Georg Seelig, Associate Professor, University of Washington (2003-2009) • Avigdor Eldar, Senior Lectuer, Tel-Aviv University (2004-2009) • David Sprinzak, Principal Investigator, Tel-Aviv University (2004-2010) • Long Cai, Professor, Caltech( 2006-2010) • James Locke, Research Group Leader, University of Cambridge (2006-2012) • Chiraj Dalal, Scientist, Achaogen (2009-2010) • Hao Yuan Kueh, Assistant Professor, University of Washington (2009-2016) • Yaron Antebi, Senior Scientist, Weizmann Institute of Science (2010-2018) • Lacramioara Bintu, Assistant Professor, Stanford University (2011-2016) • Yihan Lin, Assistant Professor, Peking University (2011-2016) • Adam Rosenthal, Senior PI, Dupont (2011-2016) • Fangyuan Ding, Assistant Professor, UC Irvine (2012-2020) • Joseph Levine, Freelance Consultant (2012-2014) • Mark Budde, Senior Postdoctoral Scholar (2013-present) • Emily Capra, Associate, McKinsey & Campany (2013-2017) • Pulin Li, Assistant Professor, MIT (2013-2019) • Joseph Markson, Consultant, Boston Consulting Group (2013-2018) • Kirsten Frieda, COO, Spatial Genomics (2014-2019) • Xiaojing Gao, Assistant Professor, Stanford Univerisity (2015-2019) • Sahand Hormoz, Assistant Professor, Harvard Medical School (2015-2017) • Amjad Askary, Postdoctoral Fellow (2016-present) • Nicolas Pelaez, Postdoctoral Fellow (2016-present) • Laurent Potvin-Trottier, Assistant Professor, Concordia University, Montreal (2017-2018) • Alejandro Granados, Postdoctoral Fellow (2018-present) • Zibo Chen, Postdoctoral Fellow (2019 – present) • Felix Horns, Postdoctoral Fellow (2019 – present) • Akanksha Thawani, Postdoctoral Fellow (2020-Present) Pre-doctoral Students • Sydney Cox, (2003-2007) • Chiraj Dalal, (2004-2009) • Shaunak Sen (2004-2011) • Joseph Levine (2005-2012) • Lauren LeBon (2007-2014) • Jonathan Young (2007-2013) • Amit Lakhanpal (2008-2013) • Fred Tan (2008-2014) 3 Elowitz, Michael B., Page 4 • John Yong (2008-2015) • Nagarajan Nandagopal (2009-2018) • Zak Singer (2009-2015) • Jin Park (2011-2017) • Ke-Huan Chow (2014-present) • Heidi Klumpe (2015-present) • Sheng Wang (2015-present) • Yitong Ma (2016-present) • Christina Su (2016-present) • Ronghui Zhu (2016-present) • Lucy Chong (2017-present) • Rachael Kuintzle (2017-present) • Duncan Chadly (2018-present) • Michael Flynn (2018-present) • Jan Gregrowicz (2018-present) • Matthew Langely (2019 – present) Patents: U.S. Patent 10,527,631 “Compositions and methods for programmable sensing and control through combinatorial molecular interactions” January 7, 2020 Publications: I. Preprints 1. Flynn MJ, Snitser O, Flynn J, Green S, Yelin I, Szwarcwort-Cohen M, Kishony R, Elowitz MB, A simple direct RT-LAMP SARS-CoV-2 saliva diagnostic, medRxiv, https://www.medrxiv.org/content/10.1101/2020.11.19.20234948v1 (2020). 2. Chow KHK, Budde MW, Granados AA, Cabrera M, Yoon S, Cho S, Huang T, Koulena N, Frieda KL, Cai L, Lois C, Elowitz MB. Imaging cell lineage with a synthetic digital recording system. BioRXiv (2020) doi: https://doi.org/10.1101/2020.02.21.958678. NIHMSID: 1592729 3. Ding F and Elowitz MB. Dynamics and functional roles of splicing factor autoregulation. BioRXiv (2020) doi: https://doi.org/10.1101/2020.07.22.216887 4. Gao XJ, Chong LS, Ince MH, Kim MS, Elowitz MB. Engineering multiple levels of specificity in an RNA viral vector. BioRXiv (2020) doi: https://doi.org/10.1101/2020.05.27.1199 II. Refereed research papers: (for reviews & commentary pieces, see below) 1. Askary A, Sanchez-Guardado L, Linton JM, Chadly DM, Budde MW, Cai L, Lois C, Elowitz, MB. In situ readout of DNA barcodes and single base edits facilitated by in vitro transcription. Nat Biotechnol (2020) Jan;38(1):66-75. 2. Ding F and Elowitz MB. Constitutive splicing and economies of scale in gene expression. Nat. Struct. Mol. Biol. (2019). Jun;26(6):424-432. doi: 10.1038/s41594-019-0226-x. 4 Elowitz, Michael B., Page 5 3. Nandagopal N,* Santat LA*, Elowitz MB. Cis-activation in the Notch signaling pathway. eLife (2019) e37880. Doi: 10.7554/eFlife.37880 [*equal contribution]. 4. Martinez-Corral R, Raimundez E, Lin Y, Elowitz MB, Garcia-Ojalvo J. Self-Amplifying Pulsatile Protein Dynamics without Positive Feedback. Cell Systems (2018). Oct 24;7(4):453-62 5. Gao XJ, Chong LS, Kim, MS, Elowitz MB. Programmable protein circuits in living cells. Science (2018). Sep 21;361(6408):1252-1258 6. Ng KNK, Yui MA, Mehta A, Siu S, Irwin B, Pease S, Hirose S, Elowitz MB†, Rothenberg EV†, Kueh HY†, A stochastic epigenetic switch controls the dynamics of the T-cell lineage commitment. eLife (2018) Nov 7:e37851 (†co-corresponding author). 7. Nandagopal N, Santat LA, Elowitz MB, “Cis-activation in the Notch
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