introducing The Power to Question the new 2007 research antibodies catalog from santa cruz biotechnology, inc.

Announcing the introduction of 7,984 NEW monoclonal and polyclonal antibodies! www.scbt.com

Toll Free: 800.457.3801 | Phone: 831.457.3800 | Fax: 831.457.3801

© 2007 Santa Cruz Biotechnology, Inc. and the Santa Cruz Biotechnology, Inc. logo are registered trademarks of Santa Cruz Biotechnology, Inc.

Now introducing

THP IL-17, IL-23, TGF-β1 ELISA, ELISPOT & Flow Cytometry

TGF-β + IL-6 (differentiation)

IL-23 (survival, expansion) IL-17 secretion

TH-17

Discover the panel of validated cytokine reagents from eBioscience

• Recombinant proteins (lowest endotoxin in the industry, 10000 Standard Data tagless, authentic, non-linked, carrier-free, bulk & small sizes) log(y) = 0.917log(x) − 2.62

0 β 10 TGF- 1, IL-17A, IL-17F, IL-23, IL-27 1000 488 ® • ELISA (matched pairs, sets, kits with pre-coated plates) −1 10 TGF-β1, IL-15, IL-17A, IL-23, IL-29/IFN-λ 100 Log Scale of OD

• Neutralization (Functional Grade antibodies are sterility & 10 1 2 3 10 10 10 IL-17 - Alexa Fluor Log Scale of [IL-23] (pg/ml) endotoxin tested; lowest endotoxin in the industry)

1 Human IL-23 (p19/p40) ELISA: Standard IL-17A, IL-23 p19 1 10 100 1000 10000 CD4 - APC curve for Human IL-23 (p19/p40) ELISA set with no cross-reactivity with p40 • ELISPOT (stand alone antibody pairs and sets) Human IL-17 IC Flow: Human PBMCs monomer or IL-12 p70, and an assay were stimulated with TPA/ionomycin in sensitivity below 15pg/ml. Granzyme B, IL-13, IL-15, IL-17A, IL-29/IFN-λ the presence of monensin for 5 hours. • Intracellular staining for flow cytometric analysis (FITC, PE, PE-Cy5, APC, Alexa Fluor® conjugates, Pacific Blue®) Granzyme B, IL-13, IL-17A, IL-1β, T-bet, IFN-α2 eBioscience carries over 6,000 premium-quality novel and staple reagents. For more information, visit www.ebioscience.com. Use code JI-FEB7 to receive a free t-shirt with your next purchase.* Human IL-17 ELISPOT: Human PBMCs * Expires 3/31/07. One offer per lab. For end users only. activated with PMA/ionomycin for 24 Alexa Fluor® and Pacific Blue® are registered trademarks of and licensed under patents assigned to Molecular Probes, Inc. for research use only. hours.

www.ebioscience.com 888.999.1371 858.642.2046 888.810.6168 [email protected] [email protected] ‘The Interplay Between Protein Phosphorylation and Ubiquitination in Cell Signalling’ 30th August – 2nd September, 2007 • Dundee, UK

Poster Abstract Submission Deadline: 15th June, 2007 www.millipore.com/symposium

Abstract Submission Deadline: 15th June, 2007

The Millipore `Young Cell Signaller’ Award is Co-sponsored by Sir Philip Cohen and Professor an initiative to recognise and reward outstanding Dario Alessi of the MRC Protein Phosphorylation Unit. research within the cell signalling area. The successful young scientist will receive £10,000 of Upstate® reagents, a cash prize of £5,000, plus a trophy. Millipore and Upstate are registered trademarks of Millipore Corporation. 07-085 Visit www.millipore.com/award for further details. © 2007 Millipore Corporation, Billerica, MA 01821 All rights reserved. Working on regulatory T cell biology?

Then don’t miss our new Treg animation!

This on-line resource is both useful and AbD Serotec has a wide range of quality educational, and offers many helpful features. human, mouse, and rat antibodies for studying regulatory T cell biology including: CD4, CD25, Overview of Treg function CD28, FOXP3 and GITR. Moderated feedback/discussion board All AbD Serotec antibodies are produced under Easy navigation plus a handy print facility ISO 9001 and guaranteed to perform to Links to journal abstracts and our full Treg specification. antibody range

Check out the animation and download our Tregs magazine at www.ab-direct.com/JI today!

North America: +1 800 265 7376 Scandinavia: +44 1865 852 728 UK & Ireland: +44 1865 852 700 Worldwide: +44 1865 852 700 JI2007.4L Germany: +49 211 93 50 310/311 Email: [email protected] France: +33 1 34 25 83 34 www.ab-direct.com 6HH0RUHZLWK6HDUFK/LJKWp$UUD\V 6HQVLWLYH3URWHLQ4XDQWLğFDWLRQ8VLQJ&XVWRPL]HG%LRPDUNHU$UUD\V

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Wouldn’t you be surprised to find over Search for your antibody of interest using these 3,500 high-quality antibodies? convenient online tools at sigma.com/antibody One reliable source provides you with this remarkable collection of antibodies. ■ Antibody Explorer

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Sigma is your source.

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sigma.com Accelerating Customers’ Success through Leadership in Life Science, High Technology and Service SIGMA-ALDRICH CORPORATION • BOX 14508 • ST. LOUIS • MISSOURI 63178 • USA Kdo2-Lipid A – an Endotoxin to replace LPS. Only from Avanti® A new preparation of the saccharolipid

glycan, Kdo2-Lipid A, is a nearly homo- geneous Re lipopolysaccharide (LPS) sub- structure with endotoxin activity equal to that

of native LPS. Kdo2-Lipid A is comparable 3 Kdo2-Lipid A to LPS and its activity is reduced by >10 in Avanti Number cells from TLR-4 deficient mice.

699500 The advantage of Kdo2-Lipid A over LPS is that it is a reproducible, defined natural product, and it can be detected by ESI/MS at the low concentrations used to stimulate

animal cells. The purity of Kdo2-Lipid A should also facilitate the structural analysis of its complexes with signaling receptors, such as TLR-4/MD2. Reference

Kdo2-Lipid A of Escherichia coli, a defined endotoxin that activates macrophages via TLR-4. Raetz, C.R.H. et al. (2006) J. of Lipid Res. 47:1097-111. Phone 800-227-0651 (205-663-2494 International) or Email [email protected] for details of Avanti’s selection of lipids of unparalleled purity visit www.avantilipids.com WE SELL THE GOOD STUFF AT AVANTILIPIDS.COM

FACULTY POSITIONS IN IMMUNOLOGY

The Department of Pathology at the University of Utah School of Medicine invites applications for tenure-track faculty positions at or above the level of Assistant Professor. We are searching for individuals with promising or established research programs in the broad areas of immunology. Candidates should have a Ph.D. and/or M.D. with a strong record of recent accomplishments as a postdoctoral fellow or have demonstrated sustained productivity as an established faculty member. Successful applicants are also expected to have a commitment to high-quality COME VISIT graduate education. THE AMERICAN ASSOCIATION Areas of interest in our current expansion include, but are not limited to, immunity and infectious disease, autoimmunity/tolerance, OF IMMUNOLOGISTS cancer immunology, macrophage/dendritic cell biology, immune signaling and molecular immunology. AT BOOTH #501! Applicants should submit electronically to [email protected] the following: 1) updated curriculum vitae, 2) description of ongoing and future research plans, 3) reprints of two recent publications and 4) the names of three individuals who can provide letters of reference supporting your application. TM The University of Utah is an affirmative action/equal IMMUNOLOGY 2007 opportunity employer. Women and minorities are Miami B each Convention Center encouraged to apply. Miami Beach, Florida Peter E. Jensen, M.D. Professor and Chair May 18-22, 2007 Department of Pathology 15 North Medical Drive RM 1100 University of Utah Salt Lake City, UT 84112 Viable Human Regulatory T Cell Analysis A new approach using CD127, CD25, and CD4

Pre Sort CD4 enriched PBMCs

CD127-PE 9.6%

CD25-FITC

Post Sort CD25 int/hi CD127 lo

CD127-PE 85%

CD25-FITC

Post Sort CD25int/hiCD127lo CD4-PerCP vs FoxP3-APC CD4-PerCP

0.055

FoxP3-APC

A revolutionary approach for identification, isolation, and characterization of viable Treg cells.

You can now obtain viable Treg cells with a novel To learn more about Regulatory T Cells visit 3-color surface staining approach. bdbiosciences.com/treg • No cellular permeabilization necessary • Isolate viable cells for further experiments • Increase recovery of CD25int/hi Treg cells Shop online at shop.bdbiosciences.com • Eliminate contaminating CD25-/int T-effector cells

BD fl ow cytometers are class (I) laser products. BD Biosciences For Research Use Only. Not for use in diagnostic or therapeutic procedures. Not for resale. BD, BD Logo and all other trademarks are the property of Becton, Dickinson and Company. © 2007 BD. 2350 Qume Drive 06-810038-7r San Jose, CA 95131 bdbiosciences.com ® ® cell sciences www.CytokineCenter.com

IL-16 (121 a.a.) PF-4 IL-16 (130 a.a.) PIGF-1 IL-17 PIGF-2 IL-17B PKA D-subunit Cytokine Center IL-17D PKC-D IL-17E PKC-J Browse our web site with over 1300 IL-17F Pleiotrophin proteins, including recombinant IL-19 PLGF-1 IL-20 Polymyxin B (PMB) cytokines, growth factors, chemokines IL-21 PRAS40 and neurotrophins. Daily shipping and IL-22 PRL-1 IL-31 PRL-2 competitive pricing are offered. Bulk Insulin PRL-3 quantities of many proteins available. IP-10 Prokineticin-2 JE Prolactin Cell Sciences also carries corresponding JNK2a1 Protirelin antibodies and cytokine ELISA kits. JNK2a2 PTHrP KC / CXCL1 PTP1B PROTEINS CD40 Ligand / TRAP G-CSF KGF PTP-IA2 4-1BBL CD95 / sFas Ligand D-Galactosidase A L-asparaginase PTP-MEG2 4-1BB Receptor CD105 / Endoglin Galectin-1 LAG-1 PTP-PEST 6 Ckine CHIPS Galectin-3 LALF Peptide sRANK ACAD8 CNTF Gastrointestinal CA LAR-PTP sRANKL ACAT2 Collagen GCP-2 LBP RANTES gAcrp30/Adipolean CREB GDF-3 LC-1 RELM-D Activin A CTACK / CCL27 GDF-9 LD-78E RELM-E Activin B CTGF GDF-11 LDH Resistin ACY1 CTGFL / WISP-2 GDNF LEC / NCC-4 RPTPE ADAT1 CTLA-4 / Fc GLP-1 Leptin RPTPJ Adiponectin CXCL16 Glucagon LIGHT RPTPP ADRP CYR61 GM-CSF LIX SCF AITRL Cytokeratin 8 Goserelin LKM SCGF-D Akt1 DEP-1 GPBB LL-37 SCGF-E Alpha-Feto Protein (AFP) Desmopressin Granzyme B Lungkine / CXCL15 SDF-1D Alpha-Galactosidase A Disulfide Oxidoreductase GROD Lymphotactin SDF-1E Angiopoietin-1 (Ang-1) E-selectin GROE sLYVE-1 Secretin Angiopoietin-2 (Ang-2) ECGF GROJ M-CSF SF20 Angiostatin K1-3 EGF GRO/MGSA MCP-1 (MCAF) SHP-2 Annexin-V Elafin / SKALP Growth Hormone MCP-2 STAT1 apo-SAA EMAP-II Growth Hormone BP MCP-3 c-Src Apoliprotein A-1 ENA-78 / CXCL5 GST-p21/WAF-1 MCP-4 TACI Apoliprotein E2 Endostatin HB-EGF MCP-5 TARC Apoliprotein E3 Enteropeptidase HCC-1 MDC (67 a.a.) TC-PTP Apoliprotein E4 Eotaxin / CCL11 HGF MDC (69 a.a.) TECK APRIL Eotaxin-2 Histdyl-tRNA synthetase MDH TFF2 Artemin Eotaxin-3 (TSC) Histrelin MEC TGF-D ATF2 Epigen HRG1-E1 Mek-1 TGF-E1 Aurora A Epiregulin I-309 MIA TGF-E2 Aurora B EPHB2 I-TAC Midkine TGF-E3 BAFF EPHB4 IFN-D MIG / CXCL9 Thymosin D1 BAFF Receptor Eptifbatide IFN-D A MIP-1D/ CCL3 sTIE-1/Fc Chimera BCA-1 / BLC / CXCL13 Erk-2 IFN-D 2a MIP-1E/ CCL4 sTIE-2/Fc Chimera BCMA Erythropoietin (EPO) IFN-D 2b MIP-3 / CCL23 TL-1A BD-1 Exodus-2 IFN-E MIP-3D/ CCL20 TNF-D BD-2 Fas Ligand IFN-J MIP-3E/ CCL19 TNF-E BD-3 Fas Receptor IFN-Omega MIP-4 (PARC) / CCL18 sTNF-receptor Type I BDNF FGF-1 (acidic) IGF-I MIP-5 / CCL15 sTNF-receptor Type II Betacellulin FGF-2 (basic) IGF-II MMP-3 TPO BMP-2 FGF-4 proIGF-II MMP-7 sTRAIL R-1 (DR4) BMP-4 FGF-5 IGFBP-1 MMP-13 sTRAIL R-2 (DR5) BMP-6 FGF-6 IGFBP-2 Myostatin TRAIL/Apo2L BMP-7 FGF-7 / KGF IGFBP-3 Nanog TSG BMP-13 FGF-8 IGFBP-4 NAP-2 TSH sBMPR-1A FGF-9 IGFBP-5 Neurturin TSLP Brain Natriuretic Protein FGF-10 IGFBP-6 NFAT-1 TWEAK BRAK FGF-16 IGFBP-7 E-NGF TWEAK Receptor Breast Tumor Antigen FGF-17 IL-1D NOGGIN Urokinase C5a FGF-18 IL-1E NOV EG-VEGF C5L2 Peptide FGF-19 IL-2 NP-1 VEGF121 C-10 FGF-20 IL-3 NT-1/BCSF-3 VEGF145 C-Reactive Protein sFGFR-1 (IIIc) / Fc Chimera IL-4 NT-3 VEGF165 C-Src sFGFR-2 (IIIc) / Fc Chimera sIL-4 Receptor NT-4 VEGF-C Calbindin D-9K sFGFR-3 / Fc Chimera IL-5 Ocreotide VEGF-C I125 Calbindin D-28K sFGFR-4 / Fc Chimera IL-6 Oncostatin M VEGF-E Calbindin D-29K sFlt-1 (native) sIL-6 Receptor Osteoprotegerin (OPG) HB-VEGF-E Calmodulin sFlt-1 (D3) IL-7 OTOR sVEGFR-1 Calcitonin Acetate sFlt-1 (D4) IL-8 (72 a.a.) Oxytocin sVEGFR-2 Carbonic Anhydrase III sFlt-1 (D5) IL-8 (77 a.a.) p38-D sVEGFR-3 www.cellsciences.com www.cellsciences.com Carcino-embryonic Antigen sFlt-1 (D7) IL-9 PAI-1 Visfatin Cardiotrophin-1 Flt3-Ligand IL-10 Parathyroid Hormone WISP-1 Caspase-3 sFlt-4 IL-11 PDGF-AA WISP-2 Caspase-6 sFlt-4 / Fc Chimera IL-12 PDGF-AB WISP-3 CD4 Follistatin IL-13 PDGF-BB WNT-1 CD14 FSH IL-13 analog PDGF-CC CD22 Fractalkine / CX3C IL-15 Persephin

480 Neponset Street, Building 12A, Canton, MA 02021 • TEL (781) 828-0610 • EMAIL [email protected] CALL TOLL FREE (888) 769-1246 • FAX (781) 828-0542 • VISIT www.cellsciences.com