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netr.Te r okn o i oprice to him for looking are They investors. et e.Ewr .Kney key a Kennedy, M. Edward Sen. setts 1 or nMnatnt moecontract impose to Manhattan in Court o akutypoeto,btGM- but protection, bankruptcy for wsAt-el-ne odn G a AG, Holding Auto-Teile-Unger owns r a e h ultx fa1985 a of text full the see can ers
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oeo 1,0 nuly u esy he says he But annually. $18,000 or dose a etn iea eaosi h early the in senators liberal feating otct,gon okr ae’,adthe and haven’t, workers ground cuts, cost nteissue. the on netdi uooeIc,a auto-parts an Inc., AutoZone in invested
ls oteErpa rc faot$1,500 about of price European the to close
or,Sn end said. Kennedy Sen. court, eeiinavrieet ie tde- at aimed advertisements television lgtatnat aeare ointerim to agreed have attendants flight aiirwt h no’ discussions union’s the with familiar oa noteat-evcsidsr.It industry. auto-services the into foray
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ohaShi,Lvscifeeuieof- executive chief Lev’s Schein, Joshua
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al in,arcrir h no said union The carrier. air Minn., Paul, rwhtruhaqiiin nEurope, in acquisitions through growth
er.Tedsaecue udnswell- sudden causes disease The years.
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h salsmn lueadreapportion- and Clause Establishment the o epiwreswt okfrere- work-force with workers Delphi for ihsruling. rights iosa otws,hs’ enal to able been hasn’t Northwest, at pilots o,tuk n rcos K adit said KKR tractors. and trucks tos,
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o i h ra fciia procedure, criminal of areas the “in ion er“htwastgte Msplan GM’s together wraps “that year .Wd,telnmr 93abortion- 1973 landmark the Wade, v. soito,rpeetn oeta 5,000 than more representing Association, rnmsinadegn lisfrau- for fluids engine and transmission
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odc.JdeAiowie hth took he that writes Alito Judge conduct. epicudanuc “something announce could Delphi ehstl eaosh a getre- “great has he senators told has he hl h w ie otnet negotiate to continue sides two the while ae nTrn tl,Slnasproducts Selenia’s Italy, Turin, in Based
n ftefv companies. five the of one
oc ii ihsadt ee oiemis- police deter to and rights civil force M adh xet h A,G and GM UAW, the expects he said GM, brinsac.I rvt meetings, private In stance. abortion aiyalw h iln osv money save to airline the allows rarily pcfe muto sue debt. assumed of amount specified
himno e hraetcl Inc., Pharmaceuticals Lev of chairman
arnCutsagesv oet en- to move aggressive Court’s Warren ih,adacnutn ihte to ties with consultant a and Mich., en fSnt oeae bu his about moderates Senate of cerns oe oetn nareetta tempo- that agreement an extend to voted
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nte esnt epDelphi. help to reason another atn utc adaDyO’Connor, Day Sandra Justice parting eeRpbia presidents. Republican were
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iosUinVtst Extend to Votes Union Pilots
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yn obigt akttefrttreat- first the market to bring to vying
otws ilnsCorp. Airlines Northwest Co. & Roberts Kravis Kohlberg lue hc ol ieG sizable a GM give could which clause, u h togywre commentary worded strongly the But heddhsproa iw ysaying by views personal his shielded o htfv ifrn opne r now are companies different five that hot
r ilrsi hsindemnity this said Miller Mr. sa“oet judge. “modest” a as ieJh oet,b contrast, by Roberts, John tice h rhndu akthsbcm so become has market orphan-drug The
htabnhle ih have. might bondholder a what ol epc rcdn n operated and precedent respect would rm or ofrain he Jus- Chief confirmation. Court preme ihhg co-payments. high with
nsacuto 300adcse nMs. in cashed and $3,000 of account ings ihGnyesnwmdcn.Wti two Within medicine. new Genzyme’s with akutypoedns uhlike much proceedings, bankruptcy i oiia iw—n18 rtoday—he or 1985 views—in political his htcudafc h oreo i Su- his of course the affect could that rusta eplwicm patients low-income help that groups
rg hysyte mte hi sav- their emptied they say they drug, n19,Bingthsfrttreatment first his got Brian 1991, In neue li nDlh’ sesin assets Delphi’s on claim unsecured hysi,dmntae ht despite that, demonstrates said, they ug lt’ esnlveso issues on views personal Alito’s Judge a asCleeas oae to donates also Celgene says man
aeaot$ nhu.T a o the for pay To hour. an $7 about make n etn pwe efell. he when up getting and ol ieteat ae general, a maker auto the give would ae ntrecss htconsistency, That cases. three in cates atbcuete fe nih into insight offer they because cant auda esta 1,0.Aspokes- A $10,000. than less at valued
er,Daa etlassat each assistant, dental a Diana, years, wle h ode a rul walking trouble had toddler the swollen eeisfrDlh’ no workers union Delphi’s for benefits lt ie ihaoto-ihsadvo- abortion-rights with sided Alito uhpeieta irre,aesignifi- are libraries, presidential Bush esta 3,0 eradhv assets have and year a $38,000 than less
a o h ot.H n i ieo 20 of wife his and He month. the for pay tcue i ie n pent eoeso become to spleen and liver his caused It esos eie elhcr n other and health-care retiree pensions, or fApasi hldlha Judge Philadelphia, in Appeals of Court et yteRaa n ereH W. H. George and Reagan the by ments inswtotisrne fte earn they if insurance, without tients
obdmr hnhsetr take-home entire his than more sorbed l. ere h o a ace disease. Gaucher had boy the learned Ill., luesaigta oe tsed on spends it money that stating clause ht samme fteTidCircuit Third the of member a as that, etra ihdzn fohrdocu- other of dozens with yesterday as egn ie h rgfe opa- to free drug the gives Celgene says.
260rti rc.Ta ol aeab- have would That price. retail $2,600 l,E n eg erne fLombard, of DeGrenier Peggy and Ed old, ihDlh,G a nindemnity an has GM Delphi, with h eiieaalbefrfe, he free,” for available medicine the h oie’ lispitdout pointed allies nominee’s The h ahntnTmsadreleased and Times Washington the
opy$7.2o h eiiesnearly medicine’s the of $771.72 pay to air hntersnBinws2years 2 was Brian son their When savior. ne t 99siofarrangement spinoff 1999 its Under nuac aso u opn gives company our or pays insurance cmd,a diitainspokesman. administration an Schmidt, h omns eotderirby earlier reported comments, The
r s ere ewudb required be would he learned Ash Mr. o ains rhndushv ena been have drugs orphan patients, For r elh nuht a rhealth or pay to enough wealthy are ato it.” of part h egnamnsrto, adSteve said administration,” Reagan the itn tonygeneral. attorney sistant
n o’ fetptet.“ihrpeople “Either patients. affect don’t and e rhndus Gleevec. drugs, orphan new hwvrti un u,G ilb a be will GM out, turns this “however
mrcn h upre h oiisof policies the supported who Americans oiio eea oajba euyas- deputy as job a to general solicitor airfrBrian for Savior A
ephscmaydvlpnwdrugs new develop company his help r s’ otrpecie n fthe of one prescribed doctor Ash’s Mr. fn rdcindsutos n that and disruptions” production no of g,h a mn h atmjrt of majority vast the among was he ago, rnfrfo i o sassatt the to assistant as job his from transfer
r ako aspieincreases price says Jackson Mr. yeo ekmaa nopa disease. orphan an as leukemia of type ost epu,sc steassurance the as such us, help to sons he eia fie tWellPoint. at officer medical chief brincsstdy Tet years “Twenty today. cases abortion brin”h rt hl ekn a seeking while wrote he abortion,”
ibe”h says. he fiable,” ac 03 h oenetdfnsthis defines government The 2003. March eaddta Mhs“ o frea- of lot “a has GM that added He rodnr ot”sy a Nussbaum, Sam says cost,” traordinary rv o ug lt ol uein rule would Alito Judge how prove ttto osntpoetargtt an to right a protect not does stitution
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rgfrhr W etil etta rma from that felt certainly “We further. drug hrayi oeo,Oi,wsdiag- was Ohio, Pomeroy, in Pharmacy okr.G sietial intertwined inextricably is GM workers. i,teesls omt eoit dis- negotiate to room less there’s big, h ht os lyddw the down played House White The or htrca n tncquotas ethnic and racial that Court
iyt as h rc fhscompany’s his of price the raise to nity onAh 1 ahe tteFruth the at cashier a 51, Ash, John eei urneste aefrDelphi for have they guarantees benefit uhcmeiinadtemresaren’t markets the and competition much a e.LnonCae fRoeIsland. Rhode of Chafee Lincoln Sen. can oenethsage nteSupreme the in argued has government
o a h rc fVlaea nopportu- an as Velcade of price the saw son
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e.Ea aho nin n Republi- and Indiana of Bayh Evan Sen. otne rmPg A3 Page From Continued
rcdi taot$,0 ot.M.Jack- Mr. month. a $4,400 about at it priced elyatreprydsuso ihGM, with discussion three-party a really icut ybyn nvlm rbuying or volume in buying by discounts h oto xesv eiie,includ- medicines, expensive of cost the
iloso olr eeoigVelcade, developing dollars of millions lt’ i o o eel Views Reveals Job for Bid Alito’s o ulnihi oasr htti is this that assert to is outlandish not hmwst aeepoespy3%of 30% pay employees make to was them ehcmais sisrr o oget to do, insurers as companies, tech
as,wihsy tsetmn er and years many spent it says which Mass.,
n ni em fngtain.Wa is What negotiations. of terms in on ing hs opne r obranwt bio- with bargain to try companies These rme eeisi eea as n of One ways. several in benefits trimmed
imPamcuiasIc fCambridge, of Inc. Pharmaceuticals nium
Imntgigt e nowa sgo- is what into get to going not “I’m otoln ot o itcnlg drugs. biotechnology for costs controlling e leCosadBu hedpa that plan Shield Blue and Cross Blue new
aktfrtesm acri 03 Millen- 2003. in cancer same the for market
elndt lbrt nthem. on elaborate to declined n raqiiguista pcaiein specialize that units acquiring or ing r elysice h opn oa to company the switched Kelley Mr.
e rhndu,Vlae aeto came Velcade, drug, orphan new A
h aeo episUWwresbut workers UAW Delphi’s of fate the 0mlinmmes n tesaestart- are others and members, million 30 utcud’ fodta, esays. he that,” afford couldn’t just
eepie uhhigher. much priced were
andtesame. the mained rhn.Teatdfnsopa diseases orphan defines act The orphans. h r ncniun icsin about discussions continuing in are phi n. nIdaaoi-ae nue with insurer Indianapolis-based an Inc., yshat-nuac ot y3% “We 35%. by costs health-insurance ny’s
u eas,h as aycne drugs cancer many says, he because, but
h eot n h oto h rgre- drug the of cost the and report, the u ttre u htteeaealtof lot a are there that out turned it But cnwegdta M h A n Del- and UAW the GM, that acknowledged omng hs ot,WellPoint costs, these manage To
iedus ol aerie h compa- the raised have would drugs, sive
as tcs oet aeo market, or make to more cost it cause
ao eiltv hnersle after resulted change legislative major
nterhat plans. health their in a n E oetS See Miller “Steve” S. Robert CEO and man onaino elhCare. Health on Foundation ln hc oee vntems expen- most the even covered which plan,
onJcsn asdtepientbe- price—not the raised Jackson, John
redu rga,terpr ad No said. report the program, drug free narcn neve,Dlh Chair- Delphi interview, recent a In ieyt aefwptet edn them needing patients few have to likely uddb h leCosadBu Shield Blue and Cross Blue the by funded tyn ihtecmayseitn health existing company’s the with Staying
lm.Tecmayscifexecutive, chief company’s The eloma.
ain doae”i twrntfrthe for weren’t it if advocates” patient ihteUWrgrigDelphi. regarding UAW the with ob orr htms nueswere insurers most that rare so be to rm20 o20,acrigt study a to according 2003, to 2002 from ignaadOi,fcdatuhchoice. tough a faced Ohio, and Virginia
aetp fcne aldmlil my- multiple called cancer of type rare
lndt omn nG’ discussions GM’s on comment to clined oe“eitnet h rcn among pricing the to “resistance more rhndus h iesswr thought were diseases The drugs. orphan n rhndusrs 3 e member per 23% drugs—rose orphan ing ayIc,acano 2du trsi West in stores drug 22 of chain a Inc., macy
98 otr icvrdi epdteta treat helped it discovered doctors 1998,
MsoewmnTn ioet de- Simonetti Toni spokeswoman GM rc.Gnyemyhv experienced have may Genzyme price. intwrytomc bu h rc of price the about much too worry didn’t ra mle ain ouain includ- populations patient smaller treat hnoesen eeisa rt Phar- Fruth at benefits overseeing then
onatrtedu aet aktin market to came drug the after Soon
lnutlnx year. next until plan a oeb hrigisrr h full the insurers charging by more far iesuefrboehmdcnsthat medicines biotech for use viders tfrt otepoesadinsurers and employers most first, At mle opne.I 02 er Kelley, Jerry 2002, In companies. smaller
lrpennytss mn te things. other among tests, pregnancy ular
xetdt emd nta pension that on made be to expected oe nec ntgvnfe u makes but free given unit each on money etcl—h emhat-nuac pro- health-insurance term ceuticals—the h iigcs sepcal adon hard especially is cost rising The oatraiebtt ufraddie.” and suffer to but alternative no
insse,rqiigptet otk reg- take to patients requiring system, tion
inpninpa,tog odcso is decision no though plan, pension lion nulsedn nseilypharma- specialty on spending Annual h eotsi h opn loses company the said report The aigteedus ainswudhave would patients drugs, these making fodt oe vrtig”h says. he everything,” cover to afford
rv h eiieudratgtdistribu- tight a under medicine the prove
ol vnulytriaeis$. bil- $8.5 its terminate eventually could esays. he I n adfrb h government. the by for paid and NIH h epepyn o elhcr can’t care health for paying people the
ahntntaegop Wtotour “Without group. trade Washington eewsal oprud h D oap- to FDA the persuade to able was gene
ne h akutycd,Delphi code, bankruptcy the Under
hysrml odvlpbte methods, better develop to scramble they eerhwsdn ysinit tthe at scientists by done was research atta ntepeetenvironment, present the in that fact ehooyIdsr raiain a Organization, Industry technology nte16sfrcuigbrhdfcs Cel- defects. birth causing for 1960s the in
xsiglbrcontract. labor existing
a i ecnaeo h il vnas even bill, the of percentage big a pay emntd I’ l elcino the of reflection a all “It’s terminated. eo h rg tsi uho h initial the of much said It drug. the velop ae rewo,peieto h Bio- the of president Greenwood, James hldmd a uldoftemarket the off pulled was Thalidomide
akutyjdeo e.1 ovi its void to 16 Dec. on judge bankruptcy
aaecsssc smkn employees making as such costs manage rv htwsterao okrwas worker a reason the was that prove ae ezm pn 2. ilo ode- to million $29.4 spent Genzyme mated h otprpteti eyhg, says high,” very is patient per cost the i o ee et pill. a cents seven for zil
ece ihteUW tcnaka ask can it UAW, the with reached
sn butisrmn prahs to approaches” “blunt-instrument using u r ebwt asi a ehr to hard be can it says Leibowitz Mr. but eeomn ftedu.Terpr esti- report The drug. the of development ml populations, small have you “When hti ssl yohrcmaisi Bra- in companies other by sold is it that
as fn gemn nwg usis cuts wage on agreement no If vals. necmayi itbrh nuesare Insurers Pittsburgh. in company ance ofr esnbcueo elhcosts, health of because person a fire to et odce nivsiainit the into investigation an conducted ment, eti rg ygvn oeo taway. it of some giving by drugs certain h rgi oiepniet make to inexpensive so is drug The
prtoscmeiiewt lblri- global with competitive operations opoi leCosadBu hedinsur- Shield Blue and Cross Blue nonprofit ihcs ftermdcns tsillegal It’s medicines. their of cost high h eea fieo ehooyAssess- Technology of Office federal the oete epptet h a’ afford can’t who patients help they note eti ido cancer. of kind certain
tnest ls ae omk t U.S. its make to wages slash to needs it fpamc far tHgmr n. a Inc., Highmark at affairs pharmacy of entree o aof eas fthe of because layoffs for targeted been tl,tecs a ohg hti 1992, in that high so was cost the Still, h au fpout htsv ie.They lives. save that products of value the ieefc flpoy hnltrfra for later then leprosy, of effect side
ytm oeetois epihssaid has Delphi electronics. to systems ins”sy ct oel iepresident vice Howell, Scott says tients,” er rmpol h a hyhave they say who people from hears anpatients. tain eiie.Te a h ihpie reflect prices high the say They medicines. hndu ttsfrisuei raiga treating in use its for status phan-drug
eri ait fprsfo steering from parts of variety a in year o’ comdt elteneso pa- of needs the well accommodate don’t nhat nuac,sy eoften he says insurance, health on enaon o eae,i eevdor- received it decades, for around been opn logv h rgfe ocer- to free drug the gave also company neti eerhaddvlpeto new of development and research in invest
at upir eln t$5blina billion $15 it selling supplier, parts rhndu ot aebdthings—they bad “are costs orphan-drug n 0 mlyr n hi employees their and employers 800 ing oaot$3 huhtaioiehas thalidomide Though $53. about to ra n dl ain ahya.The year. each patient adult one treat edt aeszal rft ote can they so profits sizeable make to need
rtcinOt ,i yfrG’ largest GM’s far by is 8, Oct. protection urn aso oigwt exploding with coping of ways Current elhAvct,apiaefr advis- firm private a Advocate, Health ili 98adhssnerie h price the raised since has and 1998 in pill lcna omk nuhmdcn to medicine enough make to placentas rgcmayeeuie a they say executives company Drug
epi hc ie o bankruptcy for filed which Delphi, n.cifmdclofcrwonwruns now who officer medical chief Inc. ioiepl omre ttepieo 6a $6 of price the at market to pill lidomide oen a hreta much.” that charge can someone al,i okezm rm2,0 human 22,000 from enzyme took it nally, hr r etn e up.” fed getting are where
ie elhcr Mwudhv opay. to have would GM care health tiree egn op ruh tha- a brought Corp. Celgene utfn tucncoal that unconscionable it find just n o ifcl twst rdc:Origi- produce: to was it difficult how ing costebad n mrcn every- Americans and board, the across
o n o uho hi esoso re- or pensions their of much how and for tion. ramn,D.Hfnrsy:“I says: Haffner Dr. treatment,
ezm xlie h rc ynot- by price the explained Genzyme rcs”H astepieo rg i unfair “is drugs of price the says He prices.”
hs rgfrGuhrdsaecssaot$6,0 year. a $360,000 about costs disease Gaucher for drug whose
r n oryrtre Mi responsible is GM retirees hourly and ers
eev rtcinfo competi- from protection receive oe oGnyesGaucher Genzyme’s to comes
h notnt osqec fincreasing of consequence unfortunate the
nyeFo 200Placentas 22,000 From Enzyme ihter1-erodsn Brian, son, 17-year-old their with
dadPgyDeGrenier Peggy and Ed
tisei hc epihul work- hourly Delphi which is issue At
eeomn ot fadu to drug a of costs development h il,sesy.Ytwe it when Yet says. she field, the ypamcuia opne,i lohas also it companies, pharmaceutical by
fta urne s’ clear. isn’t guarantee that of
ista intoiial pay originally didn’t that nies hndus tsusitrs in interest spurs it drugs, phan rc f$0,0 erprpatient. per year a $200,000 of price iea eeaigitrs ncrandrugs certain in interest generating at tive
A-epiwres huhteextent the though workers, UAW-Delphi
as hshsalwdcompa- allowed has This ways. hncmaispoi nor- on profit companies When ett akt hriga average an charging market, to ment ytelgsain“sovosyqieeffec- quite obviously “is legislation the by
ie elhcr n ieisrneof insurance life and care health tiree
hyaebigue nnew in used being are they says. n19,Gnyebogttetreat- the brought Genzyme 1991, In hl h ee-ermnpl guaranteed monopoly seven-year the While
ne h aofbnft,pnin,re- pensions, benefits, layoff the antee
egvnt le eiie,if medicines, older to given be ntehat-aeaea”she arena,” health-care the in nopa drug. orphan an rhndus”Rp amnsy today. says Waxman Rep. drugs,” orphan
99siofo epi Mare oguar- to agreed GM Delphi, of spinoff 1999
rhndu ttscnalso can status Orphan-drug odinvto n excitement and innovation good ctv faohrboehfr developing firm biotech another of ecutive W i o xett e h ihcs of cost high the see to expect not did “We
A okr n eies ne the Under retirees. and workers UAW
hsyear. this Ralf-Finn Hestoft see to want also I but patients, an nGnyesbadadi he ex- chief is and board Genzyme’s on mains esv oproduce. to pensive
xeto Msolgto oDelphi’s to obligation GM’s of extent
faot$0mlinfrtedrug the for million $70 about of Idntwn opne ogouge to companies want don’t “I hreta uh”sy r li,wore- who Blair, Mr. says much,” that charge ilgclmte ae hmmr ex- more them makes matter biological
h w ie r lodsusn the discussing also are sides two The
uei rjce ohv sales have to projected is ture csrcieopa-rgstatus. orphan-drug receive ucts
hrdu.“ ee rae ecould we dreamed never “I drug. cher h rcs fcaigteclst make to cells the coaxing of process the
l o eieet codn oDelphi. to according retirement, for ble
ain ahya.Tejitven- joint The year. each patient ain n eie hc prod- which decides and cations
inda vnhge rc o h Gau- the for price higher even an sioned otoldcnanr.Tecmlxt of complexity The containers. controlled
urdfrUWwrest eoeeligi- become to workers UAW for quired
naeaecs f$7,0 per $175,000 of cost average an h D.Ta fiervesappli- reviews office That FDA. the
c o eohlas r eme envi- Termeer Mr. hemophiliacs. for uct iecls rw nseie temperature- sterile, in grown cells, live
ieyaso h 0yastpclyre- typically years 30 the of years five
ramn omre n20 at 2003 in market to treatment rhnPout eeomn at Development Products Orphan
opn htsl 5,0--erprod- $50,000-a-year a sold that company rg r yial rtispoue by produced proteins typically are drugs
450atv A okr r within are workers UAW active 24,500 ihGnye ruh the brought Genzyme, with afe,drco fteOfc of Office the of director Haffner,
ezm ie er eme rma from Termeer Henri hired Genzyme ymxn hmcl,biotechnology chemicals, mixing by
h atrsi.Aothl fDelphi’s of half About said. matter the iMrn najitventure joint a in BioMarin, nafe cnm, asMarlene says economy,” free a in
ies,h says. he disease, rdtoa eiie,wihaemade are which medicines, traditional
A ol rfr epefmla with familiar people prefer, would UAW lion. hrefropa rg.“elive “We drugs. orphan for charge
,0 ains nteUS ihGaucher with U.S. the in patients” 4,000 g nutywsi t nac.Unlike infancy. its in was industry ogy
udo noG’ eso uda the as fund pension GM’s into or fund aiaino oeta 1bil- $1 than more of talization olmto htcmaiscan companies what on limit no
ed hnIsi hr ee maybe, were, there said I when heads
rhnDu c n18,tebiotechnol- the 1983, in Act Drug Orphan
uotwudg noteDlh pension Delphi the into go would buyout i,Boai a aktcapi- market a had BioMarin lic, ieohrmdcns hr is there medicines, other Like
etr’“yswudrl aki their in back roll would “eyes vestors’ hnPeietRaa indthe signed Reagan President When
hte epiwreswoacp a accept who workers Delphi whether ihnmnh fgigpub- going of months Within ercm rmtedrug. the from came year
akt eoeteOpa rgAt in- Act, Drug Orphan the Before market. r eaieyinexpensive.” relatively are
tti al tg,i sunclear is it stage, early this At te symptoms. other ys$. ilo nrvnelast revenue in billion $2.2 ny’s
eca oeta eas ftesmall the of because potential mercial as W eetikn fceiasthat chemicals of thinking were “We says:
orfo bu 2 nhour. an $25 about from hour n mardvso,among vision, impaired and bu n-hr ftecompa- the of one-third About
ramn intse ohv uhcom- much have to seem didn’t treatment rg fLmtdCmeca au. She Value.” Commercial Limited of Drugs
ae o no okr oaon 1 an $10 around to workers union for wages eae etldevelopment mental delayed aysbgetsuc fprofit. of source biggest pany’s
e opn.A is,teexperimental the first, At company. new ramns aldte “Significant them called treatments,
epihssi tnest u hourly cut to needs it said has Delphi bi ebwt,afre Aetna former a Leibowitz, Abbie eiinyi nezm htlasto leads that enzyme an in deficiency rgfrGuhrrmisb a h com- the far by remains Gaucher for drug
h otatt aeteezm ohis to enzyme the make to contract the n17,rcmedn netvsfrsuch for incentives recommending 1979, in
hr pivso confidence. investor up shore ra sgigt bankrupt.” to going is Brian osfe rmtedsae asdb a by caused disease, the from suffer to isaddansis tl,teorphan the Still, diagnostics. and dics
ezm,tegvrmn transferred government the Genzyme, e rgEauto.Arpr h wrote she report A Evaluation. Drug New
nNrhAeiaadsrgln to struggling and America North in as Tiko o ayemployers many how of “Think says. l ntedvlpdwrdaeestimated are world developed the in ple n inydsae swl sorthope- as well as disease, kidney and
li co-founded Blair Mr. when 1981, In
ikl omrha fteFAsOfc of Office FDA’s the of head former Finkel,
iewe ti iigu asv losses massive up piling is it when time aeti scetn, r DeGrenier Mr. creating,” is this wake oyacaioi .Fwrta ,0 peo- 4,000 than Fewer I. polysaccharidosis el eiie o acr cardiology cancer, for medicines sells
rast wl n oe odeteriorate. to bones and swell to organs a hs aedsae, asMarion says diseases,” rare these had
on ervn Mo eeu ta at revenue of GM depriving down, ot bu 3000aya.“hn fthe of “Think year. a $360,000 about costs o aegntcdsaecle muco- called disease genetic rare a for te opne n oa eeosand develops today and companies other
ie aa,cniinta asscertain causes that condition fatal, times aepout vial o ainswho patients for available products make
oc oeG sebypat oshut to plants assembly GM some force
egs13pud n i treatment his and pounds 143 weighs nciia rasaptniltreatment potential trials—a clinical in hrmdcn,Gnyehsbought has Genzyme medicine, cher
etfrGuhrdsae ae some- rare, a disease, Gaucher for ment rftcne.“l ewne od was do to wanted we “All center. profit
tie tcranDlh lnscould plants Delphi certain at Strikes
e o rhat nuac.Binnow Brian insurance. health or job a get h rms fasnl rhndu still drug orphan single a of promise the rple yrvnefo h Gau- the from revenue by Propelled
ainlIsiue fHat satreat- a as Health of Institutes National inttikteenceduswudb a be would drugs niche these think didn’t
l aiirwt h ak said. talks the with familiar ple
er tmymk thr o i o to son his for hard it make may it fears nta ulcofrn ae otyon mostly based offering public initial aigtedu e ta ocs,h says. he cost, no at it get drug the taking
yewsdvlpdb cetssa the at scientists by developed was zyme hs ntal novdwt h law the with involved initially Those
rpsdb epimngmn,peo- management, Delphi by proposed
usoe rtco h rgshg price, high drug’s the of critic outspoken aionafr,rie 6 ilo nan in million $67 raised firm, California fodi. bu 0 ftepol now people the of 10% About it.” afford
nvriySho fMdcn.Teen- The Medicine. of School University tients.
het osrk opoetwg cuts wage protest to strike to threats
r erne,wohsbcm an become has who DeGrenier, Mr. 99 iMrnPamcuia n. a Inc., Pharmaceutical BioMarin 1999, e ogv taa o rei epecan’t people if free for away it give to fer
rcswieh a eerhra Tufts at researcher a was he while tracts r lga etfe nspoto pa- of support in testified Klugman Mr.
olntflo hog ihrecent with through follow wouldn’t
sCmatwl aeme.” have will Comcast as opne trc tr-pcptl In capital. start-up attract companies a fodi ihu nuac.W pre- We insurance. without it afford can
mna nyeudrgvrmn con- government under enzyme imental ncoddcnrsinlhaig n1981, in hearings congressional crowded In
ne htDlh-A workers Delphi-UAW that ances
ih, esi.“u ’ eefra long as for here I’m “But said. he night,” h rhndu akthshelped has market orphan-drug The hrig$7,0 oaptet oone No patient? a to $175,000 charging
er li a enmkn nexper- an making been had Blair Henry ayfudi rftbeeog omarket. to enough profitable it found pany
eedn nG eevn assur- receiving GM on dependent
e sdt ncigo 0t 0dosa doors 70 to 60 on knocking to used get eec ewe hrig$0,0 or $200,000 charging between ference
trcigSatU Capital Start-Up Attracting
iee o expensive. too sidered olntgtatetetbcuen com- no because treatment a get couldn’t
tl al n uotwudlkl be likely would buyout Any fail. still
o ocs op A g 7 aeto have I 57, age “At Corp. Comcast for
rdtepie esy,“htstedif- the “What’s says, he price, the ered
ownFAapoa.Ti suulycon- usually is This approval. FDA win to insre Qic, nwihapatient a which in “Quincy,” series sion
pfrdsuso,adtetlscould talks the and discussion, for up h a ic retired. since has who er eln al evcsdoor-to-door services cable selling year, se h h opn antlow- hasn’t company the why Asked
iloso olr o ulciia trials clinical full for dollars of millions oecne,md neioeo h televi- the of episode an made cancer, bone
h ulnso n elaestill are deal any of outlines The prahwt er, asM.Kelley, Mr. says heart,” a with approach er,h ial on uhajbthis job a such found finally he years, today.
c ae ol aet pn esof tens spend to have would maker ics akKumn hs rte a rare a had brother whose Klugman, Jack
ohn o$2billion. $12 to nothing W’etidt aea nltcbusiness analytic an take to tried “We’ve fpol.Atrsacigfrthree for searching After people. of lnst a httepouto otis cost production the what say to clines
n rdcssyi’ mosbe gener- A impossible. it’s say products ing e rsd andsemwe actor when steam gained crusade Her
ae t iblt tayhr from anywhere at liability its mated nrae o$. ilo rm$600,000. from million $1.5 to increased rgcudb pedaogthousands among spread be could drug aigteGuhrdu,bth de- he but drug, Gaucher the making
rg—itc opne ihbig-sell- with companies drugs—biotech
a pnofi 99 Mhsesti- has GM 1999. in off spun was etmn y‘Quincy’ by Testimony h oto nuigisepoeshas employees its insuring of cost the mlyrs h rc fteGaucher the of price the so employer iso cl aerdcdtecs of cost the reduced have scale of mies
adrt rv qiaec nbiotech in equivalence prove to harder
oe oDlh hnteprsunit parts the when Delphi to moved rvosya.Oe h atfv years, five past the Over year. previous elzdh eddt okfralarge a for work to needed he realized ssmwa oe oa. esy econo- says He today.” lower somewhat is
a nodrt i D prvl u it’s But approval. FDA win to order in nal
as ftersalnumbers. small their of cause
ain o omrG okr who workers GM former for gations nuac ot oe1%i 04oe the over 2004 in 15% rose costs insurance nepeimuafral.H ashe says He unaffordable. premium ance ie asta ie nlto,“h price “the inflation, given that says tive,
htispouti dnia oteorigi- the to identical is product its that eebigdsrmntdaantbe- against discriminated being were
muto eso n elhcr obli- health-care and pension of amount ihrc-as rt hrayshealth- Pharmacy’s Fruth co-pays, higher fhssnsdu aeeeyn’ insur- everyone’s made drug son’s his of r eme,Gnyescifexecu- chief Genzyme’s Termeer, Mr.
eeiscmaymrl utshow must merely company generics ii ihs epewt aediseases rare with People rights: civil
Mi ibefra undetermined an for liable is GM vnwt t mlye paying employees its with Even ihasalepoe eas h cost the because employer small a with rc f$0,0 e ain ahyear. each patient per $200,000 of price
rg.Frrglrplssc sPoa,a Prozac, as such pills regular For drugs. r rudhrcs hog h rs of prism the through case her argued ers
akutyfiling. bankruptcy usaypriua ain’ case. patient’s particular any cuss ash nefl rsue olaeajob a leave to pressured felt once he says ace rgrmisa naverage an at remains drug Gaucher
prvlo eei esoso biotech of versions generic of approval eiie o aecniin.M.Mey- Ms. conditions. rare for medicines
netit tmigfo Delphi’s from stemming uncertainty eiie h adNvri olntdis- couldn’t Novartis said She medicine. o ilfr nteftr.M.DeGrenier Mr. future. the in fare will son oa,atr1 er ntemre,the market, the on years 14 after Today,
hr sn eea rcs o gaining for process federal no is there inpsigtedu nutyt develop to industry drug the pushing tion
euetetra fasrk n labor and strike a of threat the reduce nGevcwone eppyn o the for paying help need who Gleevec on u i ahrwrisaothwhis how about worries father his But aktecuiiyfrtenwversion. new the for exclusivity market
ayopa rg.Ta’ because That’s drugs. orphan many aionaDmca,t uselegisla- pursue to Democrat, California a
okr,btsc uot ol help could buyouts such but workers, opn a oln oavs patients advise to hotline a has company n nte10mtrbutterfly. 100-meter the in ing ldtecmayt nte seven-year another to company the tled
xie,teei fe ocmeiinfor competition no often is there expires, ainsta re e.HnyWaxman, Henry Rep. urged that patients
ne n biaint u u Delphi out buy to obligation any under oatssoewmnsy the says spokeswoman Novartis A osrn esiscmeiiey specializ- competitively, swims he strong so oiidcls h rhnDu c enti- Act Drug Orphan The cells. modified
vnatrtesvnya monopoly seven-year the after Even s eeshle ul olto of coalition a build helped Meyers Ms.
upirs3,0 A okr.G isn’t GM workers. UAW 34,500 supplier’s akut u patients.” our bankrupts iust eev iekyifsos n is and infusions, biweekly receive to tinues rg rwn h nyei genetically in enzyme the growing drug,
ae osfe rmtecondition. the from suffer to mated oecmo disease. common more iint eieetfrsm fteauto the of some for retirement to sition t”sy h us,SnyCri.“It Corbin. Sandy nurse, the says it,” i.Tdyahg-colsno,Bincon- Brian senior, high-school a Today kid. hae n ae a fpouigthe producing of way safer and cheaper
er bu 5,0 epeaenwesti- now are people 250,000 About year. tfie ntssfrtetn another, treating for tests in failed it in aeispyolades h tran- the ease and payroll its pare tion, ooywe ooycnafr opyfor pay to afford can nobody when nology er,h okdadatdlk n other any like acted and looked he years, n19,Gnyefgrdota out figured Genzyme 1994, In
o$. ilo y19 n 26blinlast billion $2.6 and 1996 by billion $1.4 to otne eeomn ftedu after drug the of development continued soeaigudrbnrpc protec- bankruptcy under operating is I’ erbehvn hskn ftech- of kind this having terrible “It’s
ie eeu rmEoe rwquickly grew Epogen from Revenue time. n o ortes u h opn dis- company the But Tourette’s. for ing uhada ol epDlh,which Delphi, help could deal a Such
a tydee since. ever stayed has
ices v er S edicaid M and edicare M or f enters C ; makers g u r D : rces u o S
inetmtda esta 0,0 tthe at 200,000 than less at estimated tion a eeoigadu htloe promis- looked that drug a developing was a ihtemte said. matter the with iar on elit h omlrne hr it where range, normal the into fell count
n nmai ilssptet,apopula- a patients, dialysis in anemia ing is iiino ono Johnson, & Johnson of division a ries, . . higher % 0 5 to % 20 typically is mers u cons by paid rice P . price holesale w erage v a the rom f es v recei CMS nt u disco at iiin ortr,pol famil- people retire, to division, parts eto h ulds,hswhite-blood-cell his dose, full the on went
et the lects f re price the ec, v lee G or F . CMS to reported as rers, u act f u man g u dr by charged prices sale erage v a are rices P : ote N
rvdi 99a nopa rgfrtreat- for drug orphan an as 1989 in proved ortessnrm.MNi Laborato- McNeil syndrome. Tourette’s op,G’ former GM’s Corp., Delphi at ers opyet n ot fe r Ash Mr. after month One co-payment.
me o t is rdc,Eoe,ap- Epogen, product, first its got Amgen siae 0,0 epei h ..have U.S. the in people 100,000 estimated . idely w aries v fe uot oecuaeodrwork- older encourage to buyouts offer oats htwudmk i monthly his make would that Novartis,
ly aigdosage saying ally, u ann patient per cost erage v a ide v pro to nable u ices v er S edicaid M and edicare M or f enters C and mgen A
aymsl oeet n ons An sounds. and movements muscle tary ehrvneo 34million. $354 of revenue tech h osblt fhvn h a maker car the having of possibility the r s oacaiy uddi atby part in funded charity, a to Ash Mr. 2
. total ydoe ies htcue involun- causes that disease a syndrome, aet akt h rgyeddGenen- yielded drug the market, to came ntdAt okr r discussing are Workers Auto United epe h opn vnulydirected eventually company The people.
the f o f hal than less or f nt u acco hich w sales, U.S. t u o break not does company se u beca sales ide w orld- w represents re u ig F
e eiiefrhrsnsTourette’s son’s her for medicine a get er 9yasatrtefrtversion first the after years 19 year, 1 op n the and Corp. Motors General fesfe eiieol ouninsured to only medicine free offers
umi ol rs rmhrefrsto efforts her from arise would turmoil rgbcm oewdl sd Last used. widely more became drug
iems rgcmais Novartis companies, drug most Like months 4 or f 000 , 22 $ million 3 4 $1 myeloma ltiple u M m u illenni M e d a lc e V
s eeshd’ niindsuch envisioned hadn’t Meyers Ms. h ..Rvnege ail sthe as rapidly grew Revenue U.S. the yJ By C M RACKEN C EFFREY oatsA fSwitzerland. of AG Novartis
e year per 000 , 4 $1 million 22 9 $ sclerosis ltiple u M dec I Biogen x e n o v A inyapplto faot2,0 in 20,000 about of population ciency—a rhndrug.) orphan ue n h auatrro h drug, the of manufacturer the and surer
n rprybcueo omn defi- hormone a of because properly ing sdigwl namdcn htintan isn’t that medicine a on well doing is
iebgnclighsepoe,hsin- his employer, his calling began wife
ailable v na U billion 6 2. $ re u ail f renal rom f nemia A mgen A n e Epog
sCatr1 aeProceeds Case 11 Chapter As
2
oe otetcide h ee’ grow- weren’t who children treat to mone, rftavcc ru.(e o,nw37, now son, (Her group. advocacy profit
oe h otr i us,adM.Ash’s Mr. and nurse, his doctor, the dose,
e year per 000 , 37 $ million 8 6 3 $ kemia u le myeloid hronic C artis v o N c e v ee Gl 95frisfrtdu,hmngot hor- growth human drug, first its for 1985 raiainfrRr iess non- a Diseases, Rare for Organization
ofn a o i oafr h full the afford to him for way a find To
aePyol vr Strike Avert Payroll, Pare
ehrcie rhndu rtcinin protection orphan-drug received tech s ees h o ed h National the heads now who Meyers, Ms. r s ele.“’ aighalf.” taking “I’m replied. Ash Mr.
million 40 8 $ disease cher u a G yme z en G e year per 000 , 200 $ Cerezyme
1 o hi tr ihopa rg.Genen- drugs. orphan with start their got
o mlye—a a o hm”says them,” for pay employees—can not Icntafr h rsrbddose,” prescribed the afford can’t “I
elCudHl at Firm Parts Help Could Deal
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