DOCSLIB.ORG

2021 Rnatx Program & Abstract Book

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
2021 Rnatx Program & Abstract Book 1 Dear Friends and Colleagues, Welcome to the RNA Therapeutics Institute’s third annual symposium, RNA Therapeutics: From Concept to Clinic, held virtually from the University of Massachusetts Medical School in Worcester, MA. What a year it has been for all of us, but especially for RNA! Throughout the latter half of the 20th century, RNA was thought mainly to intermediate between DNA and protein. Over the last three decades, that view has given way to the understanding that RNA plays rich and complex roles previously ascribed only to proteins. From ncRNAs to RNAi, from CRISPR to circular RNAs, we have witnessed astonishing discoveries and equally amazing translation of these breakthroughs to therapeutics and now mRNA vaccines. We are delighted to feature speakers whose fascination with RNA biology has inspired them to explore the possibilities of harnessing RNA to create therapeutics. This exceptional virtual experience will keep with our tradition of providing high-quality scientific sessions, an exhibit hall that will offer one-on-one opportunities to meet with our business partners, and social events to allow attendees to mingle, catch up with old friends, and forge new collaborations. It also promises two dynamic and inspiring keynote addresses, as well as a fun party that we know you will enjoy - all on a digital platform. To stimulate dialogue, we’ve included time in the program for discussion during our welcome reception on Wednesday afternoon, after each talk, as well as during the poster sessions, coffee networking breaks, and our RNATx party on Thursday afternoon. The scientific sessions and posters, drawn from our international call for abstracts, offer a taste of the newest work in the field and provide new opportunities to forge collaborations with current and future thought-leaders in the RNA community. We would like to thank everyone who has worked diligently to create this symposium, particularly the talented staff at the RTI. We especially thank our speakers for their enthusiastic participation. Finally, we are most grateful to our sponsors and exhibitors for their generous support. Sincerely, Phillip D. Zamore, PhD Angela Messmer-Blust, PhD RNA Therapeutics Institute UMass Medical School Symposium Co-Organizers 2 2021 RNA Therapeutics: From Concept to Clinic Contents: • Virtual Venue…………..………….………………………………………….……………….……4 • Sponsors……………………………….………………………………….……………….……….6 • Oral Program…………………………….…………………………………….…………….……10 • On-Demand Short Talk Abstracts……….………………………………………….….………..12 • Live Short Talk Abstracts…..………………………………….………….……………...………20 • Poster Program………………………………………………………………….………………..25 • Keynote & Invited Speaker Biographies…………………………………………………….….31 • Panelist & Organizer Biographies………………..………………………………….………….41 • Symposium Survey…………..………………………………….………….……………………44 • Poster Abstracts…………..………………………………….………….………..………..…….45 ___________________________________________________________________________ Cover Image: This image of the mouse cerebellum in a murine model of ALS (C9ORF BAC) shows selective uptake of antisense oligonucleotides (ASOs; green) into purkinji neurons at the interface of grey and white matter. Nuclei are shown in blue. Image by Dr. Michael Moazami, Jonathan Watts Lab, RTI, UMass Medical School. 3 Virtual Venue VENUE: RNATx2021.vfairs.com POSTERS & NETWORKING: https://spatial.chat/s/rnatx21 Tutorial & Info on Spatial Chat REGISTRATION: You will receive an email on how to activate your account for the virtual platform. Please email [email protected] if you have not received or are having trouble logging in. We recommend logging in a day prior to ensure connectivity. TECHNICAL SUPPORT: For technical support during the symposium [email protected] or call 508-380-6077. CAREER WORKSHOP, EXHIBITORS, POSTER & SCIENTIFIC SESSIONS INFORMATION Session URL Careers Under the Microscope Workshop (pre-registration required) RNATx2021.vfairs.com Wednesday, June 23rd Enter Auditorium (if registered) Keynote Sessions: Michael Rosbash and Kathy High RNATx2021.vfairs.com Wednesday, June 23rd and Friday June 25th Enter Auditorium Welcome Reception, RNATx & Sirnaomics Lobbies, sponsored by Sirnaomics https://spatial.chat/s/rnatx21 Wednesday, June 23rd Scientific Sessions RNATx2021.vfairs.com Wednesday - Friday, June 23-25th Enter Auditorium RNATx 2021 Virtual Party sponsored by ChemGenes GO REMOTE LINK Thursday, June 24th (TURN OFF YOUR VPN) Poster Sessions sponsored by Agilent Wednesday - Friday, June 23-25th h"ps://spa(al.chat/s/rnatx21 Spatial chat poster session info Exhibitors RNATx2021.vfairs.com Wednesday - Friday, June 23-25th Enter Exhibit Hall Coffee & Networking Breaks, sponsored by TriLINK h"ps://spa(al.chat/s/rnatx21 Wednesday - Friday, June 23-25th 2021 RNATx VIRTUAL PARTY Please join the RNATx party to play an interactive Game Show sponsored by ChemGenes. Teams will play against each other in mini-games of trivia, puzzles, Pictionary, and more! Who will be the ultimate RNATx Game Show Champion? EXHIBITORS We are very happy to welcome our exhibitors who kindly support this meeting. Please take the time to visit them during the networking breaks and poster sessions. 4 POSTER SESSIONS Poster Numbers Session Date/Time VOTE for the Note best poster Wednesday, June 23rd These presentation times are for a Posters: 1 - 42 & 46 Session 1 * 3.30 - 4.15pm Q&A session via Spatial Chat. Thursday, June 24th Posters: 43 - 86 Session 2 * The poster pdfs & 2 minute videos 1.15 - 2.00pm that you uploaded will stay up for the entirety of the meeting. Posters: 87 - 125 Friday, June 25th Session 3 1.15 - 2.00pm *NOTE: All posters will stay up for the entire symposium. The presentation times refer to the Q&A sessions in Spatial Chat only. SPEAKERS All oral presenters are reminded to be in their respective sessions no later than 30 minutes before the start of the session in order to meet with the session chair and to finalize their setup of presentation visuals. You will receive ALL links to your email via Zoom AND in a calendar invite. SOCIAL MEDIA Official symposium hashtag: #RNATx2021 Symposium website: www.RNATx2021.vfairs.com Twitter Account: @UMassMedRTI The organizers encourage attendees to tweet about the remarkable science that they experience at the meeting. Please respect the following rules in your posts and tweets: 1. Be polite and respectful of others 2. Be respectful of those presenters that ask attendees to refrain from tweeting content from talks and posters. 3. If you’re enjoying the conference, share it with your social media network! 4. Never post/tweet about unpublished data, and look for these icons on the speakers’ slides: Ok to screenshot, Not ok to screenshot, photograph, photograph, and/or share: and/or share: CONFERENCE HARASSMENT POLICY 2021 RNATx is dedicated to providing a harassment-free conference experience for everyone, regardless of gender, gender identity & expression, sexual orientation, disability, physical appearance, body size, race, age, or religion. We do not tolerate harassment of conference participants in any form. Conference participants violating these rules may be expelled from the conference (without a refund) at the discretion of the conference organizers. Our anti-harassment policy and how to report any violations can be found at: https://bit.ly/30AMkQz 5 With Gratitude to our Sponsors GOLD SPONSORS 6 SILVER SPONSORS 7 BRONZE SPONSORS ® SUPPORTERS 8 EXHIBITORS Eclipse GUAG CG A CU A U UC U GA U U AC G AC C C UA GU GA C BioInnovations C Sanderson Center for Optical Experimentation 9 ORAL PROGRAM Wednesday, June 23, 2021 (times listed in ET) 1.00 – 2.30pm Careers Under the Microscope Workshop (pre-registration required; separate agenda) 2.40 – 2.45pm Welcome and Keynote introduction, Phillip D. Zamore, HHMI, RNA Therapeutics Institute, UMass Medical School Keynote: Michael Rosbash, Brandeis University 2.45 – 3.30pm More than 50 years of RNA: Plus ça change... Virtual Poster Session and Exhibit Hall- VOTE for the best poster 3.30 – 4.15pm Poster Session Sponsored by Agilent Technologies RNATx Kickoff, Virtual Happy Hour via Spatial Chat Lobby, 4.15 – 5.00pm Sponsored by Sirnaomics Progr Thursday, June 24, 2021 8.55 – 9.25am Virtual Coffee & Networking, Spatial Chat Lobby Session I: Editing Session Chair: Xiaolong Dong, RTI, UMass Medical School 9.25 – 9.30am Welcome and Introduction, Phillip D. Zamore Genome editing and single cell approaches to study early human development 9.30 – 9.55am Kathy Niakan, Crick Institute In vivo gene editing in muscles and muscle stem cells 10.00 – 10.25am Amy Wagers, Harvard University 10.30 – 10.55am Development of gene-drives and a method to block them in A. gambiae Chrysanthi Taxiarchi, Imperial College of London Site-directed RNA editing: current strategies and future directions 11.00 – 11.25am Joshua Rosenthal, Marine Biological Laboratory ON DEMAND Short Talks from abstracts – Vote for your favorite talk within the conference platform! Virtual Networking & Coffee Break, Spatial Chat Lobby 11:30 – 12:00pm Sponsored by TriLink BioTechnologies Session II: RNAs in Immunity Session Chair: Kexin Zhang, RTI, UMass Medical School Innate Immune nucleic acid sensing pathways 12.15 – 12.40pm Kate Fitzgerald, UMass Medical School N6-Methyladenosine in Immunity 12.45 – 1.10pm Ye Grace Chen, Yale University ON DEMAND Short Talks from abstracts – Vote for your favorite talk within the conference platform! Virtual Poster Session and Exhibit Hall - VOTE for the best poster 1.15 – 2.00pm Poster Session Sponsored by Agilent Technologies
Load more

Recommended publications
  • TWIM Spring 2015
    SPRING 2015 No. 7 16 Ruth and Uri Arnon A legacy of scientific discovery 10 Spotlight on Dimitris Chorafas 40 Major league magnets From the President Dear Friends, This is a special issue of Weizmann Magazine as it has a new “app” that will allow you to read issue after issue by pulling it from a virtual bookshelf on your device. It is also a special issue because our cover story high- lights the quintessential Weizmann Institute couple: Prof. Ruth and Dr. Uriel Arnon, who recently gave a transformational gift for the establishment of the Ruth and Uriel Arnon Science Education Campus adjacent to the Weizmann Institute. Ruth’s career in science touches so many aspects of what the best possible science is all about—discovery and commercializa- tion, a commitment to the next generation of scientific leaders, and investment at a national level to ensure the vibrancy of science and technology for all of Israel. In this issue, you will also read about a major area of new emphasis, nuclear magnetic resonance research. This area is enabling scientists from a variety of fields to watch biological processes in action at super-high resolution, and examine and refine non-biological phenomena such as artificial nano-materials like never before. It is a new horizon and The Weizmann Institute has historically led in this field and recently recruited several young scientists who will enable us to move forward, in a dramatic way, in NMR. Last but not least: This year we are celebrating 50 years Credits since the establishment of diplomatic relations between Israel and Germany, a relationship that was, in great part, an A publication of the Department of Resource outgrowth of scientific ties between the Weizmann Institute Development and the Department of Media Relations and the Max Planck Society.
    [Show full text]
  • Annual Report 2009
    vol. 32 no. 2 annual report 2009 The Magazine of The University of Massachusetts Medical School Expanding our Reach L., the plural of life The name of this magazine encompasses the lives of those who make up the University of Massachusetts Medical School community, for which it is published. They are students, faculty, staff, alumni, volunteers, benefactors and others who aspire to help this campus achieve national distinction in education, research and public service. UMass Medical School’s mission is to advance the health and well-being of the people in the commonwealth and the world through pioneering advances in education, research, and health care delivery. As you read about this dynamic community, you’ll frequently come across references to partners and programs of UMass Medical School (UMMS), the Commonwealth of Massachusetts’ only public medical school, educating physicians, scientists and advanced practice nurses to heal, discover, teach and care, compassionately. Commonwealth Medicine UMass Medical School’s innovative public service division that assists state agencies and health care organizations to enhance the value and quality of expenditures and improve access and delivery of care for at-risk and uninsured populations. www.umassmed.edu/commed The Research Enterprise UMass Medical School’s world-class investigators, who make discoveries in basic science and clinical research and attract more than $242 million in funding annually. UMass Medical School/UMass Memorial Development Office The department that supports the academic and research enterprises of UMass Medical School and the clinical initiatives of UMass Memorial Health Care by forming vital partnerships between contributors and health care professionals, educators and researchers.
    [Show full text]
  • Cooperation and Discrimination in Academic Publishing
    COOPERATION AND DISCRIMINATION IN ACADEMIC PUBLISHING A thesis submitted for the degree of Doctor of Philosophy by Boontarika Paphawasit Department of Economics and Finance College of Business, Arts and Social Sciences Brunel University London, UK June 2017 ABSTRACT This thesis consists of four essays in collaboration and discrimination. The first essay examines the role of collaboration as a determinant of publication productivity in the field of economics, measured by means of citations, journal rank, and journal impact factor. The analysis employs cross-sectional data of 1,512 journal publications published in 2012 in 16 economics journals. The findings show a positive effect of team size on publication productivity, whereas research teams consisting of only one gender perform better in terms of research quality than gender-mixed teams. The analysis also indicates a negative relationship between female-dominated teams and research productivity. The second essay examines the impact of physical attractiveness on productivity. As literature found a strong impact on wages and career progression, it can be either due to discrimination in favour of good-looking people or can reflect an association between attractiveness and productivity. We utilise a context of academic publishing where there is no or limited face-to-face interaction. Using data on 2,800 authors, the results suggest that physical attractiveness has significantly important benefits. The third essay also considers the effect of physical attractiveness, as assessed based on pictures of top scientists, on their probability of winning the Nobel Prize. In contrast, the results show that attractiveness is negatively correlated with the probability of being awarded the Nobel, with the magnitude of this effect being not negligible.
    [Show full text]
  • California Institute of Technology Biology and Biological Engineering Annual Report 2019 Introduction
    California Institute of Technology Biology and Biological Engineering Annual Report 2019 Introduction The annual report for Caltech's Division of Biology and Biological Engineering (BBE) presents major research accomplishments of faculty, students, and staff during the previous academic year. This report covers October 1, 2018 to September 30, 2019. Front Cover Illustration Rendered atomic force microscopy image of a nanoscale tic-tac-toe game Credit: Lulu Qian Lab Back Cover Illustration Rendered atomic force microscopy image of a hexagon-shaped 540 nanometer- wide molecular structure made of 24 triangular DNA origami tiles Credit: Lulu Qian Lab Front Cover: Back Cover: 1 News, Events, and People Annual Report | Biology and Biological Engineering | 2019 Press Releases 6 Annual Retreat 12 Ferguson Prize 15 2 News, Events, and People Annual Report | Biology and Biological Engineering | 2019 Reddy 16 Professional Awards and Honors 17 Seminars 18 Named Lectures 23 3 News, Events, and People Annual Report | Biology and Biological Engineering | 2019 Current Graduate Students 25 Graduating Class of 2019 26 Financial Support and Donors 30 4 News, Events, and People Annual Report | Biology and Biological Engineering | 2019 Faculty and Research Staff 33 Division Staff 39 Biology and Biological Engineering Faculty Research Updates 40 Biology and Biological Engineering Facilities 272 5 Press Releases Annual Report | Biology and Biological Engineering | 2019 09/26/2019 Otherworldly Worms with Three Sexes Discovered in Mono Lake Lori Dajose The extreme environment of Mono Lake was thought to only house two… 09/26/2019 Stewart and Lynda Resnick Pledge $750 Million to Caltech to Support Environmental Sustainability Research Kathy Svitil 09/16/2019 Postdoc Receives $1.5M Award for Exceptional Early-Career Scientists Elsy Buitrago Delgado 09/13/2019 Beyond the Limits of Nature: A Conversation with Kaihang Wang Lori Dajose Assistant Professor Kaihang Wang works to rewrite the rules of life by….
    [Show full text]
  • California Institute of Technology Biology and Biological Engineering Annual Report 2018 Introduction
    California Institute of Technology Biology and Biological Engineering Annual Report 2018 Introduction The annual report for Caltech's Division of Biology and Biological Engineering (BBE) presents major research accomplishments of faculty, students, and staff during the previous academic year. This report covers October 1, 2017 to September 30, 2018. Front Cover Illustration A chick embryo showing neural crest cells (green) emerging from the forming brain and migrating to the periphery Credit: Marianne Bronner Lab Back Cover Illustration A gastrula stage chick embryo showing BMP4 expression in green that defines the neural plate border. The purple signal is a modulator of BMP activity. Credit: Marianne Bronner Lab Front Cover Back Cover 1 News, Events, and People Annual Report | Biology and Biological Engineering | 2018 Press Releases 7 Annual Retreat 15 Lawrence L. and Audrey W. Ferguson Prize 19 2 News, Events, and People Annual Report | Biology and Biological Engineering | 2018 Dr. Nagendranath Reddy Biological Sciences Thesis Award 20 Professional Awards and Honors 21 Seminars 22 Named Lectures 28 3 News, Events, and People Annual Report | Biology and Biological Engineering | 2018 Symposiums 30 Current Graduate Students 34 Graduating Class of 2018 36 4 News, Events, and People Annual Report | Biology and Biological Engineering | 2018 Financial Support and Donors 40 Faculty and Research Staff 43 Division Staff 49 5 News, Events, and People Annual Report | Biology and Biological Engineering | 2018 Biology and Biological Engineering Faculty Research Updates 50 Biology and Biological Engineering Facilities 280 6 Press Releases Annual Report | Biology and Biological Engineering | 2018 10/10/2018 Faculty Join Caltech Caltech welcomes 12 faculty members who will join the Institute’s six divisions over the academic year, representing fields ranging from Cosmo chemistry and microeconomics to genome engineering and the philosophical underpinnings of quantum theory.
    [Show full text]
  • 40Th Annual Presentation Ceremony
    40th Annual thursday / april 14, 2011 Presentation Ceremony Lewis S. Rosenstiel award for distinguished work in the basic medical sciences brandeis university In 1971, the Lewis S. Rosenstiel Award for Distinguished Work in Basic Medical Science Research was established as an expression of the conviction that educational institutions have an important role to play in the encouragement and development of basic science as it applies to medicine. Medals are presented annually at Brandeis University on the basis of recommendations from a panel of outstanding scientists selected by the Rosenstiel Basic Medical Sciences Research Center. Awards are given to scientists for recent discoveries of particular originality and importance to basic medical science research. A $30,000 prize accompanies the award. Since its inception, Brandeis University has placed great emphasis on basic science and its relationship to medicine. With the establishment of the Rosenstiel Basic Medical Sciences Research Center, made possible by the generos- ity of Lewis S. Rosenstiel in 1968, research in basic medical science at Brandeis has been expanded significantly. These awards provide a way to extend the center’s support beyond the campus community. The winners of the 2011 Lewis S. Rosenstiel Award for Distinguished Work in Basic Medical Sciences are C. David Allis, professor in the Laboratory of Chromatin Biology and Epigenetics at The Rockefeller University, and Michael Grunstein, professor of biological chemistry at the University of California, Los Angeles. These two innovative scientists established the key molecular connections among histones, histone modifications and chromatin structure and their effects on the regulation of gene transcription. Presentation Ceremony presiding James E.
    [Show full text]
  • Institute of Medicine (IOM)
    INTERNATIONAL SUMMIT ON HUMAN GENE EDITING A GLOBAL DISCUSSION PLANNING COMMITTEE, SPEAKER, AND MODERATOR BIOGRAPHIES *David Baltimore, former president of the California Institute of Technology (Caltech) from 1997-2006, is President Emeritus and the Robert Andrews Millikan Professor of Biology. He is an accomplished researcher, educator, administrator, and public advocate for science and engineering and is considered one of the world's most influential biologists. Awarded the Nobel Prize in Physiology or Medicine in 1975 for his research into viral replication that provided the key to understanding the life cycle of retroviruses, Baltimore has profoundly influenced national science policy on such issues as recombinant DNA research and the AIDS epidemic. His present research focuses on control of inflammatory and immune responses as well as on the use of gene therapy methods to treat HIV and cancer in a program called "Engineering Immunity." In addition, he co-directs the Joint Center for Translational Medicine, an activity that joins Caltech and the University of California, Los Angeles, in a program to translate basic science discoveries into clinical realities. Baltimore's numerous honors include the 1999 National Medal of Science and 2000 Warren Alpert Foundation Prize. He is past president and chair of the American Association for the Advancement of Science, and a member of the U.S. National Academy of Sciences and U.S. National Academy of Medicine. He has published nearly 700 peer-reviewed articles. Baltimore received his BA in chemistry from Swarthmore College in 1960 and a PhD in 1964 from The Rockefeller University. *Françoise Baylis is a professor and Canada Research Chair in Bioethics and Philosophy at Dalhousie University.
    [Show full text]
  • ETHICS Doudna Fauci Horvath Plummer Zhang 2016
    CRISPR-CAS SYMPOSIA GENE EDITING HIV/AIDS VACCINES PROGRAM 2016 TECHNOLOGY Barrangou Charpentier ETHICS Doudna Fauci Horvath Plummer Zhang 2016 www.gairdner.org • @GairdnerAwards The Gairdner Symposia • Gairdner National Program • Gairdner Student Outreach Program • Gairdner Awardee Lecture Series 2016 Canada Gairdner Awardees Lecture Thursday, October 27, 2016 9:00 a.m. – 2:45 p.m. University of Toronto, Macleod Auditorium 9:00 am – 9:05 am Welcome Remarks WELCOME Dr. Janet Rossant, President and Scientific Director, Gairdner Foundation, Toronto, Ontario, Canada 9:05 a.m. – 9:10 a.m. Chair Remarks Dr. Trevor Young, Dean, Faculty of Medicine and Vice Provost, Relations with Health Care Institutions, University of Toronto, Toronto, Ontario, Canada to the 2016 Canada Gairdner Awards Symposia in Toronto. We are proud to 9:10 a.m. – 10:10 a.m. continue our tradition of presenting some of the world’s leading scientists to talk CRISPR-Cas Systems in Bacteria: Discovery and Applications to you about their latest work. Our international award winners will explore the Dr. Rodolphe Barrangou, Associate Professor, Department of Food, Bioprocessing and Nutrition expanding potential of the CRISPR technique for gene editing, and our Wightman Sciences; Todd R. Klaenhammer Distinguished Scholar in Probiotics Research, North Carolina State and Global Health awardees will discuss their experience with HIV/AIDS research University, Raleigh, North Carolina, USA and to the role of research and health policy at home and across the world. On Friday the speakers will step beyond the discovery of the CRISPR-Cas system to Dr. Philippe Horvath, Senior Scientist, DuPont, Dangé-Saint-Romain, France explore the frontiers of its potential as a potent tool in human health, disease control and environmental engineering.
    [Show full text]