Summer 2021 of Engineering Newsletter
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Second Quarter 2017
Press release Second quarter 2017 Issued: Wednesday, 26 July 2017, London U.K. GSK delivers further progress in Q2 and sets out new priorities for the Group Q2 sales of £7.3 billion, +12% AER, +3% CER Total loss per share of 3.7p, +59% AER, +29% CER; Adjusted EPS of 27.2p, +12% AER, -2% CER Financial highlights • Pharmaceutical sales, £4.4 billion, +12% AER, +3% CER, Vaccines sales, £1.1 billion, +16% AER, +5% CER, Consumer Healthcare sales, £1.9 billion,+10% AER, flat at CER • Group operating margin 28.5%; Pharmaceuticals 33.6%; Vaccines 33.7%; Consumer 17.7% • Total Q2 loss per share of 3.7p reflecting charges resulting from increases in the valuation of Consumer and HIV businesses and new portfolio choices • Updated 2017 guidance: Adjusted EPS growth now expected to be 3% to 5% CER reflecting impact of Priority Review Voucher • H1 Free Cash Flow £0.4 billion (H1 2016: £0.1 billion) • 19p dividend declared for Q2; continue to expect 80p for FY 2017 Product and pipeline highlights • New product sales of £1.7 billion, +62% AER, +47% CER • HIV two drug regimen (dolutegravir and rilpivirine) filed for approval in US and EU • Shingrix filed for approval in Japan • FDA approval received for subcutaneous Benlysta for treatment of SLE New business priorities to 2020 • New priorities to strengthen innovation, improve performance and build trust • Pharmaceutical R&D pipeline reviewed with target over time to allocate 80% of capital to priority assets in two current (Respiratory and HIV/infectious diseases) and two potential (Oncology and Immuno-inflammation) -
The Academy of Medical Sciences Review 2006 Fmedsci Contents
The Academy of Medical Sciences Review 2006 FMedSci Contents 1 The Academy’s objectives and ambitions for medical science 2 A message from our President 4 Executive Director’s report 6 The strength of our Fellowship 8 How we work 10 Progress through partnership 12 Celebrating science 14 Advancing medical science and infl uencing policy 16 Building trust in science 18 Working in partnership with industry 20 The impact of research 22 Creating the next generation of medical scientists 24 Financial information 25 The Academy offi ce 14 16 18 20 22 The Academy’s objectives and ambitions for medical science The Academy of Medical Sciences promotes advances in medical science and campaigns to ensure these are converted as quickly as possible into healthcare benefi ts for society. Our 850 Fellows are the UK’s leading medical scientists from hospitals and general practice, academia, industry and the public service. Our Fellows are central to all we do. The excellence of their science, their contribution to medicine and society and the diversity of their achievements are refl ected throughout this review. The Academy seeks to play a pivotal role in determining the future of medical science in the UK, and the benefi ts that society will enjoy in years to come. We champion the UK’s strengths in medical science, including the unique opportunities for research aff orded by the NHS, encourage the implementation of new ideas and solutions – often through novel partnerships, promote careers and capacity building and help to remove barriers to progress. Throughout all our work the Academy strives to demonstrate our key attributes of excellence, independence, leadership, diversity and fl exibility. -
Third Annual World Congress on the Insulin Resistance Syndrome Atherothrombotic Disease
Reviews/Commentaries/Position Statements PERSPECTIVES ON THE NEWS Third Annual World Congress on the Insulin Resistance Syndrome Atherothrombotic disease ZACHARY T. BLOOMGARDEN, MD thalamic “clock,” which generates protein signals feeding back to create rhythmic behaviors and metabolic changes. Rhyth- his is the second of three articles re- structure, coagulation, and platelets in a mic mRNA expression of clock genes and viewing presentations at the 3rd An- prothrombotic direction (3). adipokines can also be demonstrated in T nual World Congress on the Insulin It is not apparent why insulin resis- mouse visceral adipose tissue, with adi- Resistance Syndrome, San Francisco, Cal- tance should be linked to atherosclerosis. ponectin and resistin responses both at- ifornia, 17–19 November 2005. The thrifty genotype hypothesis suggests tenuated in obese mice. Grant showed an that there is a survival advantage to insu- animal model in which pioglitazone im- proved hepatic rhythmicity. Thus, light, Diabetes and vascular disease lin resistance during periods of feast alter- as well as other stimuli such as ambient At a symposium cosponsored by the In- nating with famine (4), but that chronic ternational Society of Diabetes and Vascu- exposure to high nutrient intake converts temperature, acts via the suprachiasmatic lar Disease (www.dvdres.com), Peter the organism to the phenotype of insulin nucleus to send signals to adipocytes, the Grant (Leeds, U.K.) discussed the role of resistance sydrome and diabetes, with en- endothelium, liver, fibroblasts, cardiac insulin signaling pathways in acute coro- ergy preferentially stored in the liver and myocytes, and multiple other tissues, reg- nary syndrome (ACS), pointing out that in fat and with the clustering of risk mark- ulating reproductive, metabolic, and be- type 2 diabetes is characterized by fasting ers we have come to identify with insulin havioral aspects of life. -
Connecting Immunology
CONNECTING IMMUNOLOGY IN THE TIME OF COVID-19 BSI VIRTUAL CONFERENCE 1-2 DECEMBER 2020 CONNECTINGLOGY NO VID-19 MU OF CO IM TIME IN THE CONNECTING CONNECTING IMMUNOLOGY IN THE TIME OF COVID-19 2 IMMUNOLOGY IN THE TIME OF COVID-19 Welcome On behalf of the BSI’s Congress Committee, I would like to welcome you all to the British Society for Immunology’s virtual conference ‘Connecting immunology in the time of COVID-19’. This is the BSI’s first ever virtual conference at this scale and our committee have worked hard to develop a diverse programme of plenary and parallel sessions covering many of the hot topics within immunology, which we hope will appeal to delegates. With our cutting-edge two-day agenda coupled with our interactive online platform, we aim to bring together immunologists from the UK and worldwide, providing attendees with the latest research developments from Gary Entrican internationally acclaimed leaders in their field. We’re honoured to welcome a number of high-profile speakers including our two keynote presenters from the US, Garry Nolan and Akiko Iwasaki. Additionally, we are privileged to be joined by Sir Patrick Vallance, the Chief Scientific Adviser to the UK Government, who will speak in our COVID-19 themed plenary session alongside Paul Moss, the lead for the UK Coronavirus Immunology Consortium. Among the many other highlights of our programme, I would particularly recommend you attend our Bright Sparks sessions on the first morning, featuring ground-breaking work from promising early career researchers. Additionally, our Coronavirus Panel Discussion on the second afternoon promises to be a fascinating exchange of views on how immunology has fed into the pandemic response. -
Newsletter Spring 2018 This Is Engineering Campaign Goes Live
This is Engineering campaign goes live n January, the Academy launched This is Engineering, an engineering, which are often that it is narrow, technical unparalleled multi-year perception-change campaign that and traditional. Iseeks to rebrand engineering for young people and their influencers to encourage them to take up careers in engineering. It centres on an online and social media advertising campaign, complemented by a programme of PR activity that highlights The UK’s impending departure from the European Union and the critical role that engineering plays in shaping the future. the development of a new industrial strategy present both The first five adverts focus on engineers working in sport, an imperative and a unique opportunity to refocus efforts on design, space, fashion and technology. They direct audiences to boosting the supply of UK homegrown talent. Existing STEM an online hub, where they can learn more about the engineers engagement initiatives over the past 10 years have not had and access practical information about how to pursue a career the impact expected. The Academy has set out to lead the in engineering. profession in taking a different approach, and will work with partners from across engineering to promote the profession as In the first seven weeks following launch, the campaign reached attractive and accessible to young people. a potential 31 million people, seven million of whom have watched the videos. It also gained coverage in The Times, on Sky This is Engineering launched on 24 January, and targets 13 News, BBC Radio 4 and Radio 5 Live, among other media titles. -
E2017137 (PDF)
History of Modern Biomedicine Research Group School of History, Queen Mary University of London Mile End Road, London E1 4NS website: www.histmodbiomed.org AUDIO INTERVIEW TRANSCRIPT Sanger, Gareth: transcript of an audio interview (08-Dec-2016) Interviewer: Tilli Tansey Transcriber: Debra Gee Editors: Tilli Tansey, Apostolos Zarros Date of publication: 05-May-2017 Date and place of interview: 08-Dec-2016; Queen Mary University of London Publisher: Queen Mary University of London Collection: History of Modern Biomedicine Interviews (Digital Collection) Reference: e2017137 Number of pages: 25 DOI: 10.17636/01022653 Acknowledgments: The project management of Mr Adam Wilkinson and the technical support of Mr Alan Yabsley are gratefully acknowledged. The History of Modern Biomedicine Research Group is funded by the Wellcome Trust, which is a registered charity (no. 210183). The current interview has been funded by the Wellcome Trust Strategic Award entitled “Makers of modern biomedicine: testimonies and legacy” (2012-2017; awarded to Professor Tilli Tansey). Citation: Tansey E M (intvr); Tansey E M, Zarros A (eds) (2017) Sanger, Gareth: transcript of an audio interview (08- Dec-2016). History of Modern Biomedicine Interviews (Digital Collection), item e2017137. London: Queen Mary University of London. Note: Audio interviews are conducted following standard oral history methodology, and have received ethical approval (reference QMREC 0642). Related material has been deposited in the Wellcome Library. © The Trustee of the Wellcome Trust, London, 2017 History of Modern Biomedicine Interviews (Digital Collection) - Sanger, G e2017137 | 2 Sanger, Gareth: transcript of an audio interview (08-Dec-2016)* Biography: Professor Gareth Sanger BSc PhD DSc FBPhS FRSB (b. -
Ancient Coins
ANCIENT COINS GREEK COINS 1001 Sicily, Akgragas (495-480 BC), silver didrachm, sea eagle standing r., rev. crab within shallow incuse, certified and graded by NGC as Very Good £100-150 1002 Sicily, Syracuse, gold dilitron, Emergency issue of the Second Democracy, winter 406-5 BC, head of Athena l., wearing crested Attic helmet decorated with serpent, palmette and elaborate spiral tendrils, legend before, signed IM below neck, rev. Aegius with gorgoneion centre, wt. 1.80 gms. (Boeh., Essays Thompson pl.38, 12), a few surface marks, very fine, extremely rare - only a few specimens known £1500-2000 1003 Attica, Athens (c. 510-500 BC), silver tetradrachm, head of Athena r., in archaic style, full plume visible, rev. AΘE, owl stg. r., olive leaf to left, crescent to right, wt. 17.1gms. (HGC.4; Seltman Group H), very fine, rare £10,000-12,000 A very fine example of an early Athenian tetradrachm of superb archaic style. A well-centred strike, with the full plume of Athena’s helmet visible. This impressive archaic tetradrachm was issued a decade before the first Persian war. Athens provided the Ionian Greeks with assistance in their rebellion against the Persians, but aside from the sack of Sardes, the campaign was unsuccessful. Nonetheless, the Persian King Darius, aiming to punish Athens for their support of the Ionian rebellion, launched an invasion of Greece, landing at Marathon in 490 BC. Only twenty five miles from the city of Athens, the vastly outnumbered Athenian hoplite force crushed the invading Persian army, who turned and fled after suffering horrendous casualties. -
Download Chapter 96KB
Memorial Tributes: Volume 21 Sir Denis Rooke sheltered by HRH Prince Philip, on the occasion of the 150th anniversary of the Great Exhibition of 1851; reproduced with the permission of His Royal Highness. Copyright National Academy of Sciences. All rights reserved. Memorial Tributes: Volume 21 DENIS ROOKE 1924–2008 Elected in 1987 “For many technological contributions, including his role in design and construction of the world’s first liquefied natural gas system.” BY DAVID WALLACE SUBMITTED BY THE NAE HOME SECRETARY SIR DENIS ERIC ROOKE, OM, CBE, FREng, FRS, died September 2, 2008, aged 84. He was a commanding figure in every sense in engineering and business, whose career in the gas industry culminated as chairman for 13 years of British Gas, then a nationalized monopoly, world-leading in technical inno vation and profitable for the UK government. He was born in New Cross, in Southeast London, on April 2, 1924, the younger son of F.G. Rooke, a commercial salesman. A precocious child, he went to primary school at age 3, two years earlier than usual, but his next four years were dogged by ill- ness and were spent mostly at Great Ormond Street Hospital. He emerged at the age of 7 unable to read, write, or walk prop- erly. It made him determined: “I worked like hell.” At Westminster City school he made exceptional progress and went on to the Addey and Stanhope School and then to University College London, where he graduated with first- class honors in mechanical engineering and later did a post- graduate diploma in chemical engineering. -
Imperialmatters
32120_IM29 UK 36pp 13/2/07 12:46 pm Page 37 head ISSUE 29 WINTER 2007_IMPERIAL COLLEGE CELEBRATES ITS HUNDREDTH BIRTHDAY _ENLIVENING ENGINEERING EDUCATION _JOIN IN THE CENTENARY CELEBRATIONS_PLUS ALL THE NEWS FROM THE COLLEGE AND ALUMNI GROUPS IMPERIALmatters Alumni magazine of Imperial College London including the former Charing Cross and Westminster Medical School, Royal Postgraduate Medical School, St Mary’s Hospital Medical School and Wye College. 32120_IM29 UK 36pp 13/2/07 12:45 pm Page 34 ISSUE 29 WINTER 2007 in this issue ... 10 12 15 16 20 26 27 REGULAR FEATURES ASSOCIATION 1 editorial by Sir Richard Sykes 22 alumni group news 2 letters 24 international group news 26 alumni focus NEWS 28 media mentions 4 Imperial news 29 books 5 faculty news 30 obituaries 33 honours FEATURES 12 Imperial’s leading men_the Rectors who have guided the College during the past 100 years 15 celebrating 100 years of living science_marking the hundredth birthday of Imperial College 16 engineering a bright future: EnVision 2010_innovation in undergraduate education 20 reunited and reminiscing_bringing back memories of bygone days at the Alumni Reunion 2006 IMPERIALmatters PRODUCED BY IMPERIAL COLLEGE COMMUNICATIONS AND THE OFFICE OF ALUMNI AND DEVELOPMENT EDITOR ZOË PERKINS MANAGING EDITOR SASKIA DANIEL EDITORIAL CONTRIBUTORS LIZ GREGSON, ANNE BARRETT, DR RUTH GRAHAM, IMPERIAL COLLEGE PRESS OFFICE DESIGN JEFF EDEN PRINT PROLITHO LTD DISTRIBUTION MERCURY INTERNATIONAL LTD building the connection IS PRODUCED BY THE OFFICE OF ALUMNI AND DEVELOPMENT IMPERIAL MATTERS IS PUBLISHED TWICE A YEAR. THE NEXT ISSUE WILL BE PUBLISHED IN JULY 2007 AND THE COPY DEADLINE IS FRIDAY 18 MAY 2007 ADDRESS FOR MAGAZINE ENQUIRIES: ZOË PERKINS, OFFICE OF ALUMNI AND DEVELOPMENT, IMPERIAL COLLEGE LONDON SOUTH KENSINGTON CAMPUS, LONDON SW7 2AZ [email protected] © IMPERIAL COLLEGE LONDON, 2007.ALLRIGHTS RESERVED. -
The Ship 2013/2014
St Anne’s College Record 2013 – 2014 - Number 103 - Annual Publication of the ASM 2013 – 2014 The Ship St Anne’s College St Anne’s Careers Day 2014 - an initiative of the JCR, MCR and ASM/Keith Barnes St Anne’s College Record 2013-2014 Bristol & West Branch: Liz Alexander Photographs Number 103 Cambridge Branch: Sue Collins Annual Publication of the ASM London Branch: Clare Dryhurst All photographs unless otherwise credited Midlands Branch: Jane Darnton are the property of St Anne’s College, Committee 2013-2014 North East Branch: Gillian Pickford Oxford. Presidents: Clare Dryhurst North West Branch: Maureen Hazell and Jackie Ingram Oxford Branch: Stephanie North Front cover photo: Students hide their faces Honorary Secretary: Pam Jones South of England Branch: Maureen during Matriculation (reason unknown), Honorary Editor: Judith Vidal-Hall Gruffydd Jones October 2013/Keith Barnes; p.3, p.10, Ex Officio: Tim Gardam, Kate Davy p.71, inside back cover, and back cover – Designed and printed by Windrush Group Keith Barnes; p.24 – Digital images of new Until 2014: Kate Hampton Windrush House, Avenue Two. Library and Academic Centre supplied by Until 2015: Hugh Sutherland Station Lane, Witney, Oxfordshire OX28 4XW Fletcher Priest Architects Until 2016: David Royal Tel: 01993 772197 Contents Contents From the Editor 2 Gaudy Seminar 2013 – Tim Benton 40 ASM Presidents’ report 3 Gaudy Seminar 2013 – Mary Atkinson 42 From the Principal 4 Gaudy and Alumni Weekend 2014 44 Interview with the Principal 6 Careers – Will Harvey 47 From the Development -
Glaxosmithkline, Parent Company of Stiefel, a GSK Company
Dermatology on Wall Street GlaxoSmithKline, Parent Company of Stiefel, a GSK Company or more than 160 years, Stiefel, a GSK compa- ny, has been committed to dermatology. Following a series of acquisitions in the latter Fpart of the last decade (Connetics Corp. in 2006 and Barrier Therapeutics in 2008), Stiefel itself was acquired by GlaxoSmithKline (GSK) in July 2009. GSK, a global pharmaceutical company, GSK (NYSE: GSK) Founded: 2000 has the third highest revenues of any pharmaceuti- (Merger of Glaxo Wellcome and SmithKline Beecham) cal company globally. The company’s primary therapeutic areas include asthma, anti-virals, anti- Stiefel Founded: 1847, Acquired by GSK in 2009 infectives, cancer, diabetes, mental health, and now dermatology. Its large consumer division mar- Based: London, UK and Research Triangle Park, NC (Stiefel) kets several market-leading products, including the Number of Employees: 96,500+ world’s fastest growing toothpaste brand for the last five years (Sensodyne). On the Web: www.gsk.com Since the acquisition, Stiefel remains focused on www.stiefel.com dermatology, with a portfolio of OTC and prescrip- tions drugs for the treatment in a wide range of Officers: Andrew Witty, Chief Executive Office; Simon Bicknell, dermatologic therapeutic areas, including acne, Senior Vice President, Governance, Ethics and Assurance; John psoriasis, aesthetics, antifungal, anti-itch, and dry Clarke, President, Consumer Healthcare; Deirdre Connelly, skin. President, North American Pharmaceuticals; Simon Dingemans, Stiefel’s development in recent years has Chief Financial Officer; Marc Dunoyer, President, Asia focused on novel foam vehicle formulations, Pacific/Japan; Eddie Gray, President, Pharmaceuticals Europe; including recent additions Sorilux (calcipotriene) Abbas Hussain, President, Emerging Markets and Asia Pacific; and Extina (ketoconazole), and the antibacterial Altabax (retapamulin ointment). -
100 Days Mission to Respond to Future Pandemic Threats
1 1OO DAY S MISSION to respond to future pandemic threats Reducing the impact of future pandemics by making Diagnostics, Therapeutics and Vaccines available within 100 days A report to the G7 by the pandemic preparedness partnership 12 June 2021 2 100 Days Mission 3 Foreword The COVID-19 pandemic has caused untold damage and continues to bring loss and hardship to communities around the world, and the world’s poorest continue to suffer from unequal access to lifesaving medical tools. One cause for hope has been the unprecedented pace of the response by life sciences research and the rapid development of medical technologies to tackle this new threat. We had diagnostic tests within a week, effective therapeutics (in the form of dexamethasone) in 138 days and safe and effective vaccines in just over 300 days after Sir Patrick Vallance the WHO declared a public health emergency of international concern. These are incredible achievements given novel medicines and medical technologies have historically taken a decade or more to develop – and often as long again to reach countries at all income levels. The G7 countries have a crucial role to play, with a major stake in the international health system, a wealth of scientific expertise, and the resources to support the strengthening of health systems across the globe. In February 2021, the UK Prime Minister challenged the G7 to explore how we can harness scientific innovation and strengthen public and private collaboration to reduce the time from discovery to Melinda French Gates deployment of diagnostics, therapeutics and vaccines in a future health crisis.