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Metabolic Footprinting and Systems Biology: the Medium Is the Message
Nature Reviews Microbiology | AOP, published online 10 June 2005; doi:10.1038/nrmicro1177 REVIEWS METABOLIC FOOTPRINTING AND SYSTEMS BIOLOGY: THE MEDIUM IS THE MESSAGE Douglas B. Kell*, Marie Brown*, Hazel M. Davey‡, Warwick B. Dunn*, Irena Spasic* and Stephen G. Oliver§ Abstract | One element of classical systems analysis treats a system as a black or grey box, the inner structure and behaviour of which can be analysed and modelled by varying an internal or external condition, probing it from outside and studying the effect of the variation on the external observables. The result is an understanding of the inner make-up and workings of the system. The equivalent of this in biology is to observe what a cell or system excretes under controlled conditions — the ‘metabolic footprint’ or exometabolome — as this is readily and accurately measurable. Here, we review the principles, experimental approaches and scientific outcomes that have been obtained with this useful and convenient strategy. The METABOLOME is defined as the quantitative comple- either the transcriptome or proteome. This is because ment of low-molecular-weight metabolites present in the activities of metabolic pathways are reflected a cell under a given set of physiological conditions1–9. more accurately in the concentrations of pools of It lends itself readily to functional genomic and other metabolites than in the concentrations of the relevant analyses, as changes in a cell’s physiology as a result of enzymes (or indeed the concentrations of the mRNAs gene deletion or overexpression are amplified through encoding them). the hierarchy of the TRANSCRIPTOME and the PROTEOME, Metabolomics is therefore considered to be, in *School of Chemistry, and are therefore more easily measurable through the many senses, more ‘useful’ (that is, ‘discriminatory’) University of Manchester, metabolome, even when changes in metabolic fluxes than transcriptomics and proteomics, for the following Faraday Building, are negligible1,10–12. -
The Promise of Human Genome Editing for Rare and Genetic Disease Summary Report of the 2019 FORUM Annual Lecture
The promise of human genome editing for rare and genetic disease Summary report of the 2019 FORUM Annual Lecture The Academy of Medical Sciences The Academy of Medical Sciences is the independent body in the UK representing the diversity of medical science. Our mission is to promote medical science and its translation into benefits for society. The Academy’s elected Fellows are the United Kingdom’s leading medical scientists from hospitals, academia, industry and the public service. We work with them to promote excellence, influence policy to improve health and wealth, nurture the next generation of medical researchers, link academia, industry and the NHS, seize international opportunities and encourage dialogue about the medical sciences. Opinions expressed in this report do not necessarily represent the views of all participants at the event, the Academy of Medical Sciences, or its Fellows. All web references were accessed in February 2020. This work is © Academy of Medical Sciences and is licensed under Creative Commons Attribution 4.0 International. The Academy of Medical Sciences 3 The promise of human genome editing for rare and genetic disease Summary report of the 2019 FORUM Annual Lecture Contents Executive summary .................................................................................................... 4 An introduction to genome editing ................................................................................ 6 Genome editing: moving to the clinic ........................................................................... -
The Disclosure of Climate Data from the Climatic Research Unit at the University of East Anglia
House of Commons Science and Technology Committee The disclosure of climate data from the Climatic Research Unit at the University of East Anglia Eighth Report of Session 2009–10 Volume II Oral and written evidence Ordered by The House of Commons to be printed 24 March 2010 HC 387-II Published on 31 March 2010 by authority of the House of Commons London: The Stationery Office Limited £0.00 The Science and Technology Committee The Science and Technology Committee is appointed by the House of Commons to examine the expenditure, administration and policy of the Government Office for Science. Under arrangements agreed by the House on 25 June 2009 the Science and Technology Committee was established on 1 October 2009 with the same membership and Chairman as the former Innovation, Universities, Science and Skills Committee and its proceedings were deemed to have been in respect of the Science and Technology Committee. Current membership Mr Phil Willis (Liberal Democrat, Harrogate and Knaresborough)(Chair) Dr Roberta Blackman-Woods (Labour, City of Durham) Mr Tim Boswell (Conservative, Daventry) Mr Ian Cawsey (Labour, Brigg & Goole) Mrs Nadine Dorries (Conservative, Mid Bedfordshire) Dr Evan Harris (Liberal Democrat, Oxford West & Abingdon) Dr Brian Iddon (Labour, Bolton South East) Mr Gordon Marsden (Labour, Blackpool South) Dr Doug Naysmith (Labour, Bristol North West) Dr Bob Spink (Independent, Castle Point) Ian Stewart (Labour, Eccles) Graham Stringer (Labour, Manchester, Blackley) Dr Desmond Turner (Labour, Brighton Kemptown) Mr Rob Wilson (Conservative, Reading East) Powers The Committee is one of the departmental Select Committees, the powers of which are set out in House of Commons Standing Orders, principally in SO No.152. -
Annual Scientific Report 2013 on the Cover Structure 3Fof in the Protein Data Bank, Determined by Laponogov, I
EMBL-European Bioinformatics Institute Annual Scientific Report 2013 On the cover Structure 3fof in the Protein Data Bank, determined by Laponogov, I. et al. (2009) Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases. Nature Structural & Molecular Biology 16, 667-669. © 2014 European Molecular Biology Laboratory This publication was produced by the External Relations team at the European Bioinformatics Institute (EMBL-EBI) A digital version of the brochure can be found at www.ebi.ac.uk/about/brochures For more information about EMBL-EBI please contact: [email protected] Contents Introduction & overview 3 Services 8 Genes, genomes and variation 8 Molecular atlas 12 Proteins and protein families 14 Molecular and cellular structures 18 Chemical biology 20 Molecular systems 22 Cross-domain tools and resources 24 Research 26 Support 32 ELIXIR 36 Facts and figures 38 Funding & resource allocation 38 Growth of core resources 40 Collaborations 42 Our staff in 2013 44 Scientific advisory committees 46 Major database collaborations 50 Publications 52 Organisation of EMBL-EBI leadership 61 2013 EMBL-EBI Annual Scientific Report 1 Foreword Welcome to EMBL-EBI’s 2013 Annual Scientific Report. Here we look back on our major achievements during the year, reflecting on the delivery of our world-class services, research, training, industry collaboration and European coordination of life-science data. The past year has been one full of exciting changes, both scientifically and organisationally. We unveiled a new website that helps users explore our resources more seamlessly, saw the publication of ground-breaking work in data storage and synthetic biology, joined the global alliance for global health, built important new relationships with our partners in industry and celebrated the launch of ELIXIR. -
BBSRC Annual Report and Accounts 2007-08 HC
ANNUAL REPORT & ACCOUNTS 2007-2008 Biotechnology and Biological Sciences Research Council ANNUAL REPORT & ACCOUNTS 2007-2008 Presented to Parliament by the Secretary of State, and by the Comptroller and Auditor General, in pursuance of Schedule 1, Sections 2 [2] and 3 [3] of the Science and Technology Act 1965. Ordered to be printed by the House of Commons 16 July 2008. HC761 LONDON: The Stationery Office £18.55 Contents PART 1: MANAGEMENT COMMENTARY Chairman’s statement 1 Chief Executive’s report 3 Supporting world class research 6 Key funding data 7 Embedding Systems Biology 11 Major collaborative and multidisciplinary programmes 12 Delivering economic and social benefits 14 Collaborative research with industry 14 Commercialising research outputs 17 Tackling major challenges 20 People, skills, training and knowledge flows 22 Embedding our science in society 26 Opinion gathering and public dialogue 26 Outreach and engagement 28 Engaging young people in science 29 Corporate information 30 2007-2008 Council 30 Boards, Panels and Committees 31 Organisational developments 36 Financial review 39 Remuneration report 42 PART 2: ANNUAL ACCOUNTS Financial statements for the year ended 31 March 2008 45 This Annual Report covers the period from 1 April 2007 to 31 March 2008. BBSRC ANNUAL REPORT & ACCOUNTS BBSRC ANNUAL The Biotechnology and Biological Sciences Research Council (BBSRC), established by Royal Charter in 1994, is the UK’s principal funder of basic and strategic research across the biosciences (www. bbsrc.ac.uk). It is funded primarily by the Science Budget, through the Department for Innovation, Universities and Skills (DIUS). Our mission is to support high-class science and research training, and to promote knowledge transfer in support of bio-based industries and public engagement in bioscience. -
Winter for the Membership of the American Crystallographic Association, P.O
AMERICAN CRYSTALLOGRAPHIC ASSOCIATION NEWSLETTER Number 4 Winter 2004 ACA 2005 Transactions Symposium New Horizons in Structure Based Drug Discovery Table of Contents / President's Column Winter 2004 Table of Contents President's Column Presidentʼs Column ........................................................... 1-2 The fall ACA Council Guest Editoral: .................................................................2-3 meeting took place in early 2004 ACA Election Results ................................................ 4 November. At this time, News from Canada / Position Available .............................. 6 Council made a few deci- sions, based upon input ACA Committee Report / Web Watch ................................ 8 from the membership. First ACA 2004 Chicago .............................................9-29, 38-40 and foremost, many will Workshop Reports ...................................................... 9-12 be pleased to know that a Travel Award Winners / Commercial Exhibitors ...... 14-23 satisfactory venue for the McPherson Fankuchen Address ................................38-40 2006 summer meeting was News of Crystallographers ...........................................30-37 found. The meeting will be Awards: Janssen/Aminoff/Perutz ..............................30-33 held at the Sheraton Waikiki Obituaries: Blow/Alexander/McMurdie .................... 33-37 Hotel in Honolulu, July 22-27, 2005. Council is ACA Summer Schools / 2005 Etter Award ..................42-44 particularly appreciative of Database Update: -
Putting Science and Engineering at the Heart of Government Policy
House of Commons Innovation, Universities, Science and Skills Committee Putting Science and Engineering at the Heart of Government Policy Eighth Report of Session 2008–09 Volume I Report, together with formal minutes Ordered by the House of Commons to be printed 8 July 2009 HC 168-I Published on 23 July 2009 by authority of the House of Commons London: The Stationery Office Limited £0.00 The Innovation, Universities, Science & Skills Committee The Innovation, Universities, Science & Skills Committee is appointed by the House of Commons to examine the expenditure, administration and policy of the Department for Innovation, Universities and Skills. Current membership Mr Phil Willis (Liberal Democrat, Harrogate and Knaresborough)(Chairman) Dr Roberta Blackman-Woods (Labour, City of Durham) Mr Tim Boswell (Conservative, Daventry) Mr Ian Cawsey (Labour, Brigg & Goole) Mrs Nadine Dorries (Conservative, Mid Bedfordshire) Dr Ian Gibson (Labour, Norwich North) Dr Evan Harris (Liberal Democrat, Oxford West & Abingdon) Dr Brian Iddon (Labour, Bolton South East) Mr Gordon Marsden (Labour, Blackpool South) Dr Bob Spink (UK Independence Party, Castle Point) Ian Stewart (Labour, Eccles) Graham Stringer (Labour, Manchester, Blackley) Dr Desmond Turner (Labour, Brighton Kemptown) Mr Rob Wilson (Conservative, Reading East) Powers The Committee is one of the departmental Select Committees, the powers of which are set out in House of Commons Standing Orders, principally in SO No.152. These are available on the Internet via www.parliament.uk Publications The Reports and evidence of the Committee are published by The Stationery Office by Order of the House. All publications of the Committee (including press notices) are on the Internet at www.parliament.uk/ius A list of reports from the Committee in this Parliament is included at the back of this volume. -
Models of Biological Regulation
Models of Biological Regulation by Moritz Emanuel Beber A thesis submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Bioinformatics Approved Dissertation Committee: Prof. Dr. Marc-Thorsten Hütt (chair), Jacobs University Bremen Prof. Dr. Georgi Muskhelishvili, Jacobs University Bremen Prof. Dr.-Ing. Katja Windt, Jacobs University Bremen Prof. Dr. Stefan Bornholdt (external), Universität Bremen Date of Defense: April 17, 2015 Department of Life Sciences & Chemistry iii Statutory Declaration I, Moritz Emanuel Beber, hereby declare, under penalty of perjury, that I am aware of the consequences of a deliberately or negligently wrongly submitted affidavit, in particular the punitive provisions of § 156 and § 161 of the Criminal Code (up to 1 year imprisonment or a fine at delivering a negligent or 3 years or a fine at a knowingly false affidavit). Furthermore I declare that I have written this PhD thesis independently, unless where clearly stated otherwise. I have used only the sources, the data and the support that I have clearly mentioned. This PhD thesis has not been submitted for the conferral of a degree elsewhere. Bremen, July 11, 2017 .................................................................................. Moritz Beber iv Preface The following people deserve my sincerest thanks, more so than I can express in words. There are others whom I do not mention here but also deserve my thanks, please know that you are appreciated nonetheless. First and foremost, I thank my family for showing me, time and again, their unconditional love. Without you I simply would not be here! In particular, I thank my mother Katinka and father Thomas for being calm and analytical when I needed them to but otherwise placing their complete trust in me to go my own way. -
Astex Pharmaceuticals Announces the Appointment of President Harren Jhoti, Phd to the Bioindustry Association Board of Directors
October 10, 2012 Astex Pharmaceuticals Announces the Appointment of President Harren Jhoti, PhD to the BioIndustry Association Board of Directors DUBLIN, Calif., Oct. 10, 2012 (GLOBE NEWSWIRE) -- Astex Pharmaceuticals, Inc. (Nasdaq:ASTX), a pharmaceutical company dedicated to the discovery and development of novel small molecule therapeutics, announced that Harren Jhoti, PhD, president and director of Astex Pharmaceuticals, was appointed to the BioIndustry Association (BIA) Board of Directors. About Harren Jhoti, PhD Dr. Harren Jhoti has served as Astex Pharmaceuticals president and member of the Board of Directors since the company's formation in July 2011. He co-founded Astex Therapeutics in 1999 and was chief scientific officer until November 2007 when he was appointed chief executive. Dr. Jhoti was awarded the Prous Institute-Overton and Meyer Award for New Technologies in Drug Discovery by the European Federation for Medicinal Chemistry in 2012 and was also named by the Royal Society of Chemistry as "Chemistry World Entrepreneur of the Year" for 2007. He has published widely including in leading journals such as Nature and Science and has also been featured in TIME magazine after being named by the World Economic Forum a Technology Pioneer in 2005. Dr. Jhoti served as a non-executive director of Iconix Inc. Before starting up Astex Therapeutics in 1999, he was head of Structural Biology and Bioinformatics at GlaxoWellcome in the United Kingdom (1991-1999). Prior to Glaxo, Dr. Jhoti was a post-doctoral scientist at Oxford University. He received a BSc (Hons) in Biochemistry in 1985 and a PhD in Protein Crystallography from the University of London in 1989. -
8Th Conference AM.Pdf
Measuring the interplay between uptake and loss processes of xenobiotics 13th June 2019 Maddalena Bronzato Physical Chemistry Chemical Technologies & Operations Group Chemical Research, Jealott’s Hill Understanding losses from a foliar surface Volatilisation 2 Why is pesticide volatility so important? ● Environmental fate (loss and persistence) ● Registrability ● Activity (vapour activity and volatility as a benefit) Vapour activity on Aphids Powdery mildew on Fruit Environmental fate 3 Understanding losses from a foliar surface Volatilisation Photodegradation 4 Why is pesticide photodegradation important? ● Activity (photodegradation is one of most destructive post-application pathways) ● Environmental fate (product and persistence) ● Marketability ● Registrability Pesticide sprayed on leaf surface 5 In lab test for volatility and photodegradation Photodegradation Suntest Volatilisation Wind Tunnel 6 Testing for photodegradation - Suntest ● Atlas XLS+ Suntest ● UV-filtered xenon lamp ● Mimics sunlight intensity & spectrum ● Irradiance set to 750W/m2 ● Thermostated baseplate (circulating water @ 15ºC → baseplate ≈ 20 ± 3ºC) 7 Test for volatility- The Wind Tunnel ● Very sample-efficient means of estimating vapour pressure (typically <100µg)] ● Studies are normally run at 40C with a standard wind speed of 1m/s (no control of the R.H.) 8 Photodegradation and volatility test – glass as substrate Pros: ● Good proxy for foliar surface ● Uniform, clean substrate to use for the tests ● High-throughput test ● Worst case scenario ● Indicative but imperfect Limitations: ● Different polarity and morphology between glass and leaves–> differences in redistribution mechanism and deposit shape? 9 SEM images of leaf and glass surfaces Glass 10 Surface redistribution mechanisms Volatilisation Photodegradation Vapour Phase Redistribution 11 Different deposit – effect on photodegradation and volatility Crystalline Amorphous A highly crystalline deposit The larger the deposit area, the faster the compound volatilises. -
The Implementation of Open Access Oral and Written Evidence Contents 1994 Group – Written Evidence
SCIENCE AND TECHNOLOGY SELECT COMMITTEE The implementation of open access Oral and Written evidence Contents 1994 Group – Written evidence ............................................................................................................. 5 Academy of Social Sciences – Written evidence ................................................................................. 8 Association for Learning Technology (ALT) – Written evidence ................................................. 13 Association of Learned and Professional Society Publishers (ALPSP) – Written evidence .... 19 Jeffrey Beall, Scholarly Initiatives Librarian, University of Colorado Denver – Written evidence ...................................................................................................................................................... 24 Dr Rick Bradford – Written evidence ................................................................................................ 25 British Academy – Written evidence .................................................................................................. 27 British Heart Foundation (BHF) – Written evidence ...................................................................... 32 British Medical Journal Group (BMJ) – Written evidence .............................................................. 34 British Psychological Society (BPS) – Written evidence ................................................................. 38 British Sociological Association (BSA) – Written evidence........................................................... -
Anew Drug Design Strategy in the Liht of Molecular Hybridization Concept
www.ijcrt.org © 2020 IJCRT | Volume 8, Issue 12 December 2020 | ISSN: 2320-2882 “Drug Design strategy and chemical process maximization in the light of Molecular Hybridization Concept.” Subhasis Basu, Ph D Registration No: VB 1198 of 2018-2019. Department Of Chemistry, Visva-Bharati University A Draft Thesis is submitted for the partial fulfilment of PhD in Chemistry Thesis/Degree proceeding. DECLARATION I Certify that a. The Work contained in this thesis is original and has been done by me under the guidance of my supervisor. b. The work has not been submitted to any other Institute for any degree or diploma. c. I have followed the guidelines provided by the Institute in preparing the thesis. d. I have conformed to the norms and guidelines given in the Ethical Code of Conduct of the Institute. e. Whenever I have used materials (data, theoretical analysis, figures and text) from other sources, I have given due credit to them by citing them in the text of the thesis and giving their details in the references. Further, I have taken permission from the copyright owners of the sources, whenever necessary. IJCRT2012039 International Journal of Creative Research Thoughts (IJCRT) www.ijcrt.org 284 www.ijcrt.org © 2020 IJCRT | Volume 8, Issue 12 December 2020 | ISSN: 2320-2882 f. Whenever I have quoted written materials from other sources I have put them under quotation marks and given due credit to the sources by citing them and giving required details in the references. (Subhasis Basu) ACKNOWLEDGEMENT This preface is to extend an appreciation to all those individuals who with their generous co- operation guided us in every aspect to make this design and drawing successful.