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Llllllllllllllllll||||||L|| United States Patent [191 [11] Patent Number: 5,762,608 Wame Et A] lllllllllllllll||l||||l||||@?llllllllllllllllll||||||l|| United States Patent [191 [11] Patent Number: 5,762,608 Wame et a]. [45] Date of Patent: *Jun. 9, 1998 [541 SCANNING X-RAY IMAGING SYSTEM 4,503,854 3/1985 Jako. WITH ROTATING C-ARM 4,515,165 5/1985 Carrol ................................... .. 128/664 4,543,959 10/1985 Sepponen .............................. .. 128/653 [75] Inventors: James R. Warne. Washington. Pa.; Alvin Karlolf. Framingham; Edward J. (List continued on next page.) Botz. Winchester. both of Mass; FOREIGN PATENT DOCUMENTS Michael D. Dabrowski. North Grosvenordale. Conn. 0 253 742 7/1987 European Pat. O?". 0 265 302 9/1987 European Pat. 01f. [73] Assignee: Hologic, Inc..Wa1tham. Mass. 2238706 2/1974 Germany . 24 12 161.7 3/1974 Germany . [*1 Notice: The portion of the term of this patent 86/07531 12/1986 WIPO . 88/08688 11/1988 WIPO . subsequent to Jan. 22. 2008. has been 90/10859 9/1990 WIPO . disclaimed. OTHER PUBLICATIONS [21] Appl. No.: 337,995 Rutt. B.K.. et al.. “High Speed. High-Precision Dual Photon [22] Filed: Nov. 10, 1994 Absorptiometry”. Reprint of pester exhibited at meeting at the American Society of Bone and Mineral Research. Jun. Related US. Application Data 16. 1985. Washington. DC. Pearce. R.B.. “DPA Gaining Strength in Bone Scanning [60] Continuation of Ser. No. 980,531, Nov. 23, 1992, aban doned, which is a division of Ser. No. 360,347, Jun. 5, 1989, Debate”. Diagnostic Imaging (Jun. 1986). Pat No. 5,165,410, which is a continuation-in-part of Ser. Norland Corporation advertising brochure for OsteoStatus No. 204,513, Jun. 9, 1988, abandoned, which is a continu ation-in-pan of Ser. No. 50,726, May 15, 1987, abandoned. System pp. 1-8. [51] Int Cl.6 ....................... .. A6111 6/00 (List continued on next page.) [52] US. Cl. ........... .. 600/425; 378/55; 378/197 [58] Field of Search ................... .. 128/6531; 378154-55. Primary Examiner—-Ruth S. Smith 378/89. 119. 146. 193. 195-198; 600/425 Attorney, Agent, or Firm-Hamilton. Brook. Smith & Reynolds. RC. [56] References Cited [571 ABSTRACT U.S. PATENT DOCUMENTS A multidiagnosn'c rectilinear scanner for conducting non Re. 34,511 1/1994 O’Neill et a1. ..................... .. 128/6531 invasive diagnostic procedures of bodily tissue. Both trans 3,803,417 4/1974 Kok ....... .. 250/447 mission and emission studies are performed on a single 3,944,830 3/1976 Dissing 250/358 scanner utilizing software modules for each kind of study. 3,988,585 10/1976 O’Neill et. a1. .. 250/363 Dual energy x-ray and radioactive sources are used to 4,012,636 3/1977 Engdahl et a1. 250/363 4,107,532 8/1978 MaCovski 250/360 perform radiographic and absorptiometry transmission mea 4,144,457 3/1979 Albert . 250/445 surements. A system and method of identifying regions of 4,259,585 3/1981 Novak .... .. 250/456 interest within tissue being scanned and recording the loca 4,275,305 6/1981 Racz et a1. 250/445 tion of those regions provides an additional diagnostic 4,342,916 8/1982 Iatteau et a]. ...... .. 378/4 capability. 4,358,856 11/1982 Steivender et a1. .. 378/167 4,365,343 12/1982 Grady et a1. 378/181 4,495,645 1/1985 Ohhashi .................................... .. 382/6 25 Claims, 14 Drawing Sheets 5,762,608 Page 2 U.S. PATENT DOCUMENTS Saddler et al.. “Multimodality Imaging of the Thyroid and Parathyroid Glands”; J. Nuclear Medicine 28(1):122—129 4,590,378 5/1986 Platz ...................................... .. 250/363 4.618.133 10/1986 Siczek . .. 269/323 (Jan. 1987). 4.649.560 3/1987 Grady et a1. 378/196 “Magna Scanner”. Equipment Description. Sec. 1. pp. 4-6. 4.651.732 3/1987 Frederick 128/303 “Radioisotope Scanners. The Total Scanning system". Ohio 4,653.083 3/1987 Rossi . .. 378/196 4,657,755 4/1987 Christensen et a1. .... .. 424/1.1 Nuclear. Inc. 4,6712% 6/1987 Matsuk . .. 128/660 Raytheon Series 600 Nuclear Scanner Instruction Manual. 4,716,581 12/1987 Barud . .. 378/198 4,829,549 5/1989 Vogel et a1. 378/55 pp. 1-6 and 1-11. (Feb. 25. 1972). 4,856,044 8/1989 Tanguy et a1. .. 378/55 “Model 1735 PHO/DOT Medical Scanner Operation 4,887,286 12/1989 Seidenberg ........ .. 378/170 Manual”. Nuclear Chicago. pp. 1-2 to 2-7. 4,907,252 3/1990 Aichinger et a1. .. ..... .. 378/99 4,922,915 5/1990 Arnold et a1. .... .. 128/653 Endo et al.. “Patient Beam Positioning System Using CT 4,947,414 8/1990 Stein . .. 378/55 Images”. Physics in Medicine & Biology, 27 (1982). 5,042,486 8/1991 Pfeiler et a1. .. 128/653 5,050,608 9/1991 Watanabe et a1. .. 128/653 Tremolieres. La Medicine Nucleaire. Electronique Applica 5,119,817 6/1992 Allen . .. 128/653 tions. No. 20. pp. 71-83. (1981). 5,165,410 11/1992 Wame et a1. 128/653 Kule et al.. ‘Transmission Scanning: A Useful Adjunct to 5,261,404 11/1993 Mick et a1. ........................... .. 128/653 Conventional Emission Scanning for Accurately Keying OTHER PUBLICATIONS Isotope Deposition to Radiographic Anatomy". Dept. Radi ology 0f the School of Medicine, pp. 278.284 (Aug. 1966). A New Dimension in Dual-Photon Absorptiometry Novo Introduces the BMC-Lab 23. Light Years Ahead. Genant. 11.. “Assesing Osteoporosis: CI‘ ‘s Quantitative Lunar Radiation Corporation’s Users Manual for Lunar DP3 Advantage”. Diagnostic Imaging, (Aug. 1985). Dual Photon Scanner. Robb et al.. “An Operator-interative. Computer-controlled Brochure. “Osteotek Bone Densitometry". Medical & Sci System For High Fidelity Digitization And Analysis Of enti?c Enterprises. Inc. Biomedical Images" Zie Voar Titel Boek, De 2e Pagina, pp. Sartoris. DJ. et al.. "Trabecular Bone Density in the Proxi 12-26. mal Femur: Quantitative CT Assessment”. Radiology 160:707-712 (1986). Bone Densitometry Market Research (1986). Mazess. R.B.. et al.. “Spine and Femur Density Using Wahner et a1. “Assessment of Bone Mineral. Part 1" .1. Dual-Photon Absorptiomelry in US White Women". Bone Nuclear Medicine. 25(10):1134—1141 (1984). and Mineral, 2:211-219 (1987). Weissberger. M.A.. et al.. “Computed Tomography Scan Mazess. “Dual photon Absorptiometry and Osteoporosis ning for the Measurement of Bone Mineral in the Human Absorptiometric Instrumentation" Meting Publication. Spine”. Journal of Computer Assisted Tomography, .lacobsen. Final Progress Report. “Development of Dichro 2:254-262 (Jul. 1978). mography Techniques”. pp. 1-2 and 15-18 (May 31. 1968). US. Patent Jun. 9, 1998 Sheet 1 of 14 5,762,608 111111111111 1111 zoxp' 1111 1111111111111 1 1r1111 M US. Patent Jun. 9, 1998 Sheet 2 0f 14 5,762,608 Ill 1 111 1:2 3I a 2 US. Patent Jun. 9, 1998 Sheet 3 of 14 5,762,608 wsmwt. wmzonkm >mza2 mwzokw .EOmmDmmC. C._mzmn_ mzom mmEEb 58Maw; 8535 m'GZw\romwzm momoom >omwzm.330 ><m-xwomnom mozwommmoaqmmwEDPm ZOEQEmZQmPmmEDPm US. Patent Jun. 9, 1998 Sheet 4 of 14 5,762,608 319. THYROID Scan F’ sourcezTcggm,I—l23,I-l3l,TL-2OI \ Uptake BRAIN Source:Tc99m,I— I23 HEART Source:Tc99m,-TL-2Ol LIVER, SPLEEN Source: Tc99m,Sulfur Colloid m, LUNG S0urce:Tc99m-MAA , Fgcussed BQNE / Fracture‘ tress .5 Source:Tc99m-MDP T R EMISSION _ \ urnczrrliet;1 ate STUDIES THORASIC BMD Soon "* MANDIBULA JOINT Source:Tc99m— MDP __ KIDNEY STOMACH SourcezTC99m S PLE E N Sou rcezTc99m PAN CREAS Source: Tc99m,Se Compound GALL BLADDER, HEPTOBILIARY SourcerTc99m Compound US. Patent Jun. 9, 1998 Sheet 5 of 14 5,762,608 US. Patent Jun. 9, 1998 Sheet 6 of 14 5,762,608 US. Patent Jun. 9, 1998 Sheet 7 0f 14 5,762,608 Test 7 _ BMD = 2.90 9cm2 Scan Profile (TOTAL IMAGE) BMC 2.0- l.8-- 75 1.2 ' |.O" /77 0.8 " 0.6" 0.4- | l I 1 i I I n v 1 2O 4O 6O DISTANCE 549.9 test 7 REGION OF INTEREST # Region Regior) BMD H1 Width 1 0.88 8 6 <— Height 8 Lengih 6 Z9, 10 US. Patent Jun. 9, 1998 Sheet 9 of 14 5,762,608 l'—‘| TELESCOPING DETECTOR 4O \ 8O Em 45 /9O ‘ vIDEO MONITOR SCANNER 92 J PC/AT T v _ ELECTRONIC COMPUTER CONTROLLER + 82/ KEYBOARD I V \s4 vIDEO lMAGER ALARM PRINTER (FILM RECORDER) \96 \98 Sé £9. 13 US. Patent Jun. 9, 1998 Sheet 10 of 14 5,762,608 N6 U4 122 L__._.______._________J:__________.__/____: 14 /// US. Patent Jun. 9, 1998 Sheet 11 of 14 5,762,608 F W "820257. "oEoZ 1 “$2238 $2235; “$252 Q95:B5;E2603E250EEoixvm203% __un: +5%,._+ _ ABXSLAMQEBm// @163925m336E US. Patent Jun. 9, 1998 Sheet 12 of 14 5,762,608 4 ISO"\ PERFORM SCAN l I52 SAVE SCAN DATA 7 '54\ PROCESS/DISPLAY SCAN DATA 7 ADD MARKER |56’\ TO DISPLAY/ SET ~ SCANNER POSITION 1 MOVE MARKER/SCANNER ——> MARKERSET 7 LI60 '62 TERMINATE MARKING '64“ SAVE MARKERS l. 25,. I6 US. Patent Jun. 9, 1998 Sheet 13 0f 14 5,762,608 P4 174 '73 ‘ \X Z :44\/qg /:72 . V / US. Patent Jun. 9, 1998 Sheet 14 of 14 5,762,608 5 .762.608 1 2 SCANNING X-RAY IMAGING SYSTEM SUMMARY OF THE INVENTION WITH ROTATING C-ARM The present invention relates to the use of rectilinear RELATED U.S. APPLICHI‘ ION scanners for performing emission and transmission studies to provide diagnostic non-invasive measurements of body This application is a continuation of application Ser. No. tissue. 07/980531 ?led Nov. 23. 1992 now abandoned. which is a Divisional of Ser. No. 07/360347 ?led Jun. 5. 1989 (U.S. The apparatus utilizes a housing that can be easily adapted Pat.
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