The Abdominal Wall the Digestive Tract the Pancreas the Biliary
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The abstracts which follow have been classified for the convenience of the reader under the following headings: Experimental Studies; Animal Tumors The Abdominal Wall The Cancer Cell The Digestive Tract General Clinical and Laboratory Observa- The Pancreas tions The Biliary Tract Diagnosis and Treatment Peritoneal, Retroperitoneal. and Mesenteric The Skin Tumors The Eye The Spleen The Ear The Female Genital Tract The Breast The Genito-Urinary Tract The Oral Cavity and Upper Respiratory The Nervous System Tract The Bones and Joints The Salivary Glands The Leukemias, Hodgkin's Disease, Lympho The Thyroid Gland sarcoma Intrathoracic Tumors As with any such scheme of classification, overlapping has been unavoidable. Shall an article on II Cutaneous Melanoma, an Histological Study" be grouped with the articles on Histology or with the Skin Tumors? Shall Traumatic Cerebral Tumors go under Trauma or The Nervous System? The reader's choice is likely to depend upon his personal interests; an editor may be governed by no such considerations. The attempt has been made, there fore, to put such articles in the group where they would seem most likely to be sought by the greatest number. It is hoped that this aim has not been entirely missed. As abstractors are never perfect, and as the opinions expressed may on occasion seem to an author not to represent adequately his position, opportunity is offered any such to submit his own views for publication. The JOURNAL will not only welcome correspondence of this nature but hopes in the future to have a large number of author abstracts, so that the writer of a paper may present his subject in his own way. If readers of this JOURNAL wish to communicate with the writers of articles abstracted in its pages or to secure reprints, the editorial staff will be glad, so far as possible, to supply the addresses of these authors. Photostats of original articles will also be furnished, if desired, to be charged at cost. 150 ABSTRACTS EXPERIMENTAL STUDIES; ANIMAL TUMORS Variable Sensitivity of Different Sites of the Skin of Mice to Carcinogenic Agents, J. M. TWORT AND C. C. TWORT. J. Path. & Bact. 42: 303-316, 1936. The interscapular skin of mice is usually more sensitive to carcinogenic agents than that covering the sacral or abdominal regions, while the soles of the feet are apparently the most resistant. Animals which are sensitive in one area are usually relatively sensitive in another area. \Vhen skin areas of the same animal are compared, it is found that an area which is more sensitive to the production of benign tumors is usually, but not necessarily, more sensitive to the production of malignant tumors. There is no evidence to show that benign tumors per se in one area influence the production of benign or malignant tumors elsewhere, but there is some evidence that malignant tumors produced in one area retard the development of malignant tumors elsewhere. This may be due to the debilitating effect of the first malignant tumor. Although the average type of tumor varies with different agents, the site of painting appears to have much less effect in determining the type of tumor. The application of carcinogenic agents in one area retards tumor formation in another, the carcinogenic potency being only about one-half to two-thirds that of the control. The debilitating effect of the agent on the animal is presumably the cause. Previous applications of oleic acid to a given site cause an increase in the carcinogenic potency of tar when the tar is applied at the same site as the oleic acid. When the tarred site is different to that previously painted with oleic acid the carcinogenic potency falls below that of the control. This lowering effect is presumably again due to the general debilitating effect on the animal of the oleic acid. WM. H. WOGLmr Relation Between the Growth Rate of Tar Warts in Mice and Their Corresponding Autografts, J. C. MOTTRAM. J. Path. & Bact. 42: 79-90, 1936. Continuing his investigations on the natural history of tar warts. the author finds no close relationship between the growth rate of these warts and that of their auto grafts. The reason for this appears to be that many tar warts are composed of groups of cells which are not identical in growth capacity, so that, while one part on inoculation may grow into a benign epithelial cyst, another may result in an epithelioma, or one part may give rise to a slowly, and another to a rapidly growing epithelioma. The paper is illustrated by charts, projection drawings, and photomicrographs. WM. H. WOGLOM Liposarcoma Produced by 1 : 2-Benzpyrene, CUSHMAN D. HAAGENSEN AND OTTO F. KREHBIEL. Am, J. Cancer 27: 474-484,1936. Haagensen and Krehbiel report the production of five liposarcomas with 1 : 2 benzpyrene in a mouse and 4 guinea-pigs. The guinea-pig liposarcomas occurred among a total of 13 animals receiving multiple subcutaneous injections of 1 : 2-benzpyrene and surviving as long as 342 days. Of these animals 5 developed 8 tumors, the other 4 being fibrosarcomata. The authors attribute this high incidence of liposarcoma to the thick layer of subcutaneous fat present in the guinea-pig and conclude that lipo sarcoma, at least under the circumstances of their experiment, arises from adult fat cells as the result of long-continued chemical irritation and stimulation. Photomicrographs of the tu mors produced are included. Sarcoma Production in Mice by a Single Subcutaneous Injection of a Benzoylamino Quinoline Styryl Compound, C. H. BROWNING, R. GULBRANSEN, J. S. F. NIVEN. J. Path. & Bact. 42: 155-159, 1936. The production of sarcoma is reported in 10 out of 19 mice that lived more than eight months after injection of the dye 2 (p-amino styryl) 6 (p-acetylamino benzoylamino) 151 152 ABSTRACTS quinoline methoacetate, also called styryl 430. In ultraviolet light this substance presents a reddish fluorescence quite unlike the violet color of the carcinogenic poly cyclic hydrocarbons investigated by Kennaway and his associates. There are several outstanding features attending the production of sarcoma by styryl 430. In the first place the agent is a water-soluble synthetic organic compound unrelated to the carcinogenic substances so far reported. Secondly, one single injection of an aqueous solution is effective, and thirdly, there is a lack of any immediate local irritation following its deposition in the tissues. Experiments are in progress to see whether styryl 430 will produce carcinoma when applied to the skin, and also whether it has any estrogenic activity. The article is illustrated by photomicrographs. WM. H. WOGLOM Trichinosis and Cancer, W. SCHMIDT-LANGE. Trichinose und Krebs, Ztschr. f. Krebs forsch. 43: 264--271, 1936. After mentioning the 10 known cases of carcinoma associated with trichinosis in man and briefly discussing the relation of parasites to malignant tumors, the author describes a polymorphous-cell sarcoma of the liver in one of a large group of white mice infested during some experimental work on trichinosis. The growth, discovered when the mouse was killed five days after infestation, had destroyed almost the entire organ and had metastasized to the spleen. As the animal was but ten months old, and primary sarcoma of the liver is practically unknown in mice, the author concludes that the growth was initiated by the parasites. The article is not illustrated. [There can be little doubt that the lesion actually was a sarcoma, for the diagnosis was made in Borst's laboratory and confirmed by Fischer-Wasels. But as all the known carcinogenic agents require several months to produce their effect, it seems incredible that the trichinella should need but five days to cause a tumor involving the whole liver and metastasizing to the spleen.] W~1. H. WOGLOM Malignant Tumors in Strains of Mice Refractory to Spontaneous Cancer Following Combined Hormonal Treatment, A. LACASSAGNE. Turneurs rnalignes, apparues au cours d'un traitement hormonal combine, chez des Souris appartenant a des lignees refractaires au cancer sporrtane, Cornpt. rend. Soc. de bio!' 121: 607-609, 1936. Two litters of mice from two strains refractory to spontaneous carcinoma were given alternate weekly injections of 300 international units of estrone benzoate combined with anterior pituitary extract. In one, a female that died about seven and a half months after treatment had been started. there was found a large mediastinal tumor composed of lymphoid and epider moid elements and therefore probably of thymic origin. There was a metastasis in one kidney. One of the ovaries, which were thickly studded with corpora lutea, contained a tumor whose cells resembled those of the granulosa closely enough to make one think of a primary ovarian tumor metastasizing to the thymus. Four litter mates were still living when the report was written. A second female, that died after about five months' treatment, had a squamous-cell carcinoma of the uterus. Four litter mates were still living. Two litters from a strain in which an occasional neoplasm is observed were injected in the same way, but no new growths had appeared when the article was written. The paper is illustrated by a photomicrograph of the uterine tumor. W~1. H. \\'O(;LOM Effect of Oestrone Administration on the Mammary Glands of Male Mice of Two Strains Di1Iering Greatly in their Susceptibility to Spontaneous Mammary Car cinoma, GEORGIANA M. BONSER. J. Path. & Bact. 42: 169-181, 1936. Large doses of estrone administered to males of a cancer-susceptible (Little's line of Bagg albinos) and a cancer-resistant (Little's line of black agoutis, eRA) strain pro duced in the former a growth of ducts and localized proliferation of acini, with car- EXPERIMENTAL STUDIES; ANIMAL TUMORS 153 cinoma in 3 cases.