DOCSLIB.ORG

(12) Patent Application Publication (10) Pub. No.: US 2009/0317453 A1 Hsu Et Al

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
(12) Patent Application Publication (10) Pub. No.: US 2009/0317453 A1 Hsu Et Al US 20090317453A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2009/0317453 A1 Hsu et al. (43) Pub. Date: Dec. 24, 2009 (54) TRANSDERMAL AND TOPICAL now abandoned, which is a continuation-in-part of ADMINISTRATION OF DRUGS USING BASIC application No. 09/972,008, filed on Oct. 4, 2001, now PERMEATION ENHANCERS Pat. No. 6,582,724, which is a continuation-in-part of application No. 09/738,410, filed on Dec. 14, 2000, (75) Inventors: Tsung-Min Hsu, Minneapolis, MN now Pat. No. 6,586,000, which is a continuation-in (US); Nicole T. Gricenko, St. Louis part of application No. 09/569,889, filed on May 11, Park, MN (US); Alan T.J. Hickey, 2000, now abandoned, which is a continuation-in-part Eden Prairie, MN (US); Eric C. of application No. 09/465,098, filed on Dec. 16, 1999, Jacobson, San Diego, CA (US); now abandoned, said application No. 10/860,887 is a Rose C. LoBello, San Diego, CA continuation-in-part of application No. 09/738,395, (US); Jane Obara, San Diego, CA filed on Dec. 14, 2000, now Pat. No. 6,719,997, which (US); Eric C. Luo, Plano, TX (US) is a continuation-in-part of application No. 09/607, 892, filed on Jun. 30, 2000, now abandoned. Correspondence Address: INTELLECTUAL PROPERTY GROUP Publication Classification FREDRIKSON & BYRON, PA. (51) Int. Cl. 200 SOUTH SIXTH STREET, SUITE 4000 A 6LX 9/70 (2006.01) MINNEAPOLIS, MN 55402 (US) A6II 3L/24 (2006.01) (73) Assignee: DERMATRENDS, INC., (52) U.S. Cl. ......................................... 424/449; 514/536 Minneapolis, MN (US) (57) ABSTRACT (21) Appl. No.: 12/343,000 Methods are provided for enhancing the permeability of skin or mucosal tissue to topical or transdermal application of (22) Filed: Dec. 23, 2008 pharmacologically or cosmeceutically active agents. The methods entail the use of a base in order to increase the flux of Related U.S. Application Data the active agent through a body Surface while minimizing the (60) Continuation of application No. 10/860,887, filed on likelihood of skin damage, irritation or sensitization. The Jun. 3, 2004, now abandoned, which is a division of permeation enhancer can be an inorganic or organic base. application No. 10/177,436, filed on Jun. 20, 2002, Compositions and transdermal systems are also described. US 2009/0317453 A1 Dec. 24, 2009 TRANSIDERMAL AND TOPCAL treated with a chemical enhancer) in order to increase the ADMINISTRATION OF DRUGS USING BASIC permeability of the stratum corneum, and thereby provide for PERMEATION ENHANCERS enhanced penetration of the drug through the skin. Ideally, Such chemical penetration enhancers or “permeation enhanc CROSS-REFERENCE TO RELATED ers, as the compounds are referred to herein, are compounds APPLICATIONS that are innocuous and serve merely to facilitate diffusion of the drug through the stratum corneum. The permeability of 0001. This application is a divisional of U.S. Ser. No. many therapeutic agents with diverse physicochemical char 10/177,436 filed on Jun. 20, 2002. U.S. Ser. No. 10/177,436 is acteristics may be enhanced using these chemical enhance a continuation in part of U.S. Ser. No. 09/972,008 filed on ment means. However, there are skin irritation and sensitiza Oct. 4, 2001 and now issued as U.S. Pat. No. 6,582,724, tion problems associated with high levels of certain which is a continuation in part of U.S. Ser. No. 09/738,410 enhancers. filed on Dec. 14, 2000 and now issued as U.S. Pat. No. 0006. Accordingly, although there are many chemical 6,586,000, which is a continuation in part of U.S. Ser. No. methods of enhancing permeation, there remains an ongoing 09/569,889 filed on May 11, 2000 and now abandoned, which need for a method that is highly effective in increasing the rate is a continuation in part of U.S. Ser. No. 09/465,098 filed on at which a drug permeates the skin, does not result in skin Dec. 16, 1999 and now abandoned; and is a continuation in damage, irritation, sensitization, or the like, and can be used part of U.S. Ser. No. 09/738,395 filedon Dec. 14, 2000, which to effect transdermal delivery of even high molecular weight is a continuation in part of U.S. Ser. No. 09/607,892 filed on drugs such as peptides, proteins, and nucleic acids. It has now Jun. 30, 2000, now abandoned, the disclosures of which are been discovered that basic permeation enhancers as described incorporated herein by reference. hereinare highly effective permeation enhancers, and provide FIELD OF THE INVENTION all of the aforementioned advantages relative to known per meation enhancers. Furthermore, in contrast to many conven 0002 This invention relates generally to the topical and tional enhancers, transdermal administration of drugs with transdermal administration of pharmacologically or cosme basic permeation enhancers, employed at the appropriate lev ceutically active agents, and more particularly relates to els, does not result in Systemic toxicity. methods and compositions for enhancing the flux of pharma cologically active agents through a body Surface by treatment SUMMARY OF THE INVENTION with a basic permeation enhancer. 0007. One aspect of the invention pertains to a method for enhancing the flux of a drug through a body Surface, compris BACKGROUND OF THE INVENTION ing: (a) administering the drug to a localized region of a 0003. The delivery of drugs through the skin provides human patient's body Surface; and (b) administering a basic many advantages; primarily, such a means of delivery is a permeation enhancer to the localized region, the enhancer comfortable, convenient and noninvasive way of administer comprising a pharmaceutically acceptable base and being ing drugs. The variable rates of absorption and metabolism present in an amount effective to provide a pH within the encountered in oral treatment are avoided, and other inherent range of about 8.0-13.0 at the localized region of the body inconveniences, e.g., gastrointestinal irritation and the like, Surface during administration of the drug and to enhance the are eliminated as well. Transdermal drug delivery also makes flux of the drug through the body Surface without causing possible a high degree of control over blood concentrations of damage thereto. The pharmaceutically acceptable base can be any particular drug. an inorganic or an organic base. 0004 Skin is a structurally complex, relatively thick mem 0008 Another aspect of the invention relates to a compo brane. Molecules moving from the environment into and sition for the enhanced delivery of a drug through a body through intact skin must first penetrate the stratum corneum Surface, comprising a formulation of: (a) a therapeutically and any material on its surface. They must then penetrate the effective amount of the drug; (b) a pharmaceutically accept viable epidermis, the papillary dermis, and the capillary walls able base, in an amount effective to provide a pH within the into the blood stream or lymph channels. To be so absorbed, range of about 8.0-13.0 at the body surface during adminis molecules must overcome a different resistance to penetra tration of the drug and to enhance the flux of the drug through tion in each type of tissue. Transport across the skin mem the body Surface without causing damage thereto; and (c) a brane is thus a complex phenomenon. However, it is the cells pharmaceutically acceptable carrier Suitable for topical or of the stratum corneum, which present the primary barrier to transdermal drug administration. In one aspect of the inven absorption of topical compositions or transdermally admin tion the pH is about 8.0-11.5 and in another aspect, the pH is istered drugs. The stratum corneum is a thin layer of dense, about 8.5-10.5. The formulation is typically aqueous. The highly keratinized cells approximately 10-15 microns thick pharmaceutically acceptable base can be an inorganic or an over most of the body. It is believed to be the high degree of organic base. keratinization within these cells as well as their dense packing 0009. Yet another aspect of the invention pertains to a which creates in most cases a Substantially impermeable bar system for the enhanced topical or transdermal administra rier to drug penetration. With many drugs, the rate of perme tion of a drug, comprising: (a) at least one drug reservoir ation through the skin is extremely low without the use of containing the drug and a pharmaceutically acceptable base, Some means to enhance the permeability of the skin. in an amount effective to enhance the flux of the drug through 0005 Numerous chemical agents have been studied as a the body Surface without causing damage thereto; (b) a means means of increasing the rate at which a drug penetrates for maintaining the system in drug and base transmitting through the skin. As will be appreciated by those in the field, relationship to the body Surface and forming a body Surface chemical enhancers are compounds that are administered system interface; and (c) a backing layer that serves as the along with the drug (or in some cases the skin may be pre outer surface of the device during use, wherein the base is US 2009/0317453 A1 Dec. 24, 2009 effective to provide a pH within the range of about 8.0-13.0 at and analogs of those active agents specifically mentioned the body Surface-system interface during administration of herein, including, but not limited to, salts, esters, amides, the drug. In one aspect of the invention the pH is about prodrugs, active metabolites, inclusion complexes, analogs, 8.0-11.5 and in another aspect, the pH is about 8.5-10.5.
Load more

Recommended publications
  • K+ Channel Modulators Product ID Product Name Description D3209 Diclofenac Sodium Salt NSAID; COX-1/2 Inhibitor, Potential K+ Channel Modulator
    K+ Channel Modulators Product ID Product Name Description D3209 Diclofenac Sodium Salt NSAID; COX-1/2 inhibitor, potential K+ channel modulator. G4597 18β-Glycyrrhetinic Acid Triterpene glycoside found in Glycyrrhiza; 15-HPGDH inhibitor, hERG and KCNA3/Kv1.3 K+ channel blocker. A4440 Allicin Organosulfur found in garlic, binds DNA; inwardly rectifying K+ channel activator, L-type Ca2+ channel blocker. P6852 Propafenone Hydrochloride β-adrenergic antagonist, Kv1.4 and K2P2 K+ channel blocker. P2817 Phentolamine Hydrochloride ATP-sensitive K+ channel activator, α-adrenergic antagonist. P2818 Phentolamine Methanesulfonate ATP-sensitive K+ channel activator, α-adrenergic antagonist. T7056 Troglitazone Thiazolidinedione; PPARγ agonist, ATP-sensitive K+ channel blocker. G3556 Ginsenoside Rg3 Triterpene saponin found in species of Panax; γ2 GABA-A agonist, Kv7.1 K+ channel activator, α10 nAChR antagonist. P6958 Protopanaxatriol Triterpene sapogenin found in species of Panax; GABA-A/C antagonist, slow-activating delayed rectifier K+ channel blocker. V3355 Vindoline Semi-synthetic vinca alkaloid found in Catharanthus; Kv2.1 K+ channel blocker and H+/K+ ATPase inhibitor. A5037 Amiodarone Hydrochloride Voltage-gated Na+, Ca2+, K+ channel blocker, α/β-adrenergic antagonist, FIASMA. B8262 Bupivacaine Hydrochloride Monohydrate Amino amide; voltage-gated Na+, BK/SK, Kv1, Kv3, TASK-2 K+ channel inhibitor. C0270 Carbamazepine GABA potentiator, voltage-gated Na+ and ATP-sensitive K+ channel blocker. C9711 Cyclovirobuxine D Found in Buxus; hERG K+ channel inhibitor. D5649 Domperidone D2/3 antagonist, hERG K+ channel blocker. G4535 Glimepiride Sulfonylurea; ATP-sensitive K+ channel blocker. G4634 Glipizide Sulfonylurea; ATP-sensitive K+ channel blocker. I5034 Imiquimod Imidazoquinoline nucleoside analog; TLR-7/8 agonist, KCNA1/Kv1.1 and KCNA2/Kv1.2 K+ channel partial agonist, TREK-1/ K2P2 and TRAAK/K2P4 K+ channel blocker.
    [Show full text]
  • (12) Patent Application Publication (10) Pub. No.: US 2006/0110428A1 De Juan Et Al
    US 200601 10428A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2006/0110428A1 de Juan et al. (43) Pub. Date: May 25, 2006 (54) METHODS AND DEVICES FOR THE Publication Classification TREATMENT OF OCULAR CONDITIONS (51) Int. Cl. (76) Inventors: Eugene de Juan, LaCanada, CA (US); A6F 2/00 (2006.01) Signe E. Varner, Los Angeles, CA (52) U.S. Cl. .............................................................. 424/427 (US); Laurie R. Lawin, New Brighton, MN (US) (57) ABSTRACT Correspondence Address: Featured is a method for instilling one or more bioactive SCOTT PRIBNOW agents into ocular tissue within an eye of a patient for the Kagan Binder, PLLC treatment of an ocular condition, the method comprising Suite 200 concurrently using at least two of the following bioactive 221 Main Street North agent delivery methods (A)-(C): Stillwater, MN 55082 (US) (A) implanting a Sustained release delivery device com (21) Appl. No.: 11/175,850 prising one or more bioactive agents in a posterior region of the eye so that it delivers the one or more (22) Filed: Jul. 5, 2005 bioactive agents into the vitreous humor of the eye; (B) instilling (e.g., injecting or implanting) one or more Related U.S. Application Data bioactive agents Subretinally; and (60) Provisional application No. 60/585,236, filed on Jul. (C) instilling (e.g., injecting or delivering by ocular ion 2, 2004. Provisional application No. 60/669,701, filed tophoresis) one or more bioactive agents into the Vit on Apr. 8, 2005. reous humor of the eye. Patent Application Publication May 25, 2006 Sheet 1 of 22 US 2006/0110428A1 R 2 2 C.6 Fig.
    [Show full text]
  • The In¯Uence of Medication on Erectile Function
    International Journal of Impotence Research (1997) 9, 17±26 ß 1997 Stockton Press All rights reserved 0955-9930/97 $12.00 The in¯uence of medication on erectile function W Meinhardt1, RF Kropman2, P Vermeij3, AAB Lycklama aÁ Nijeholt4 and J Zwartendijk4 1Department of Urology, Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands; 2Department of Urology, Leyenburg Hospital, Leyweg 275, 2545 CH The Hague, The Netherlands; 3Pharmacy; and 4Department of Urology, Leiden University Hospital, P.O. Box 9600, 2300 RC Leiden, The Netherlands Keywords: impotence; side-effect; antipsychotic; antihypertensive; physiology; erectile function Introduction stopped their antihypertensive treatment over a ®ve year period, because of side-effects on sexual function.5 In the drug registration procedures sexual Several physiological mechanisms are involved in function is not a major issue. This means that erectile function. A negative in¯uence of prescrip- knowledge of the problem is mainly dependent on tion-drugs on these mechanisms will not always case reports and the lists from side effect registries.6±8 come to the attention of the clinician, whereas a Another way of looking at the problem is drug causing priapism will rarely escape the atten- combining available data on mechanisms of action tion. of drugs with the knowledge of the physiological When erectile function is in¯uenced in a negative mechanisms involved in erectile function. The way compensation may occur. For example, age- advantage of this approach is that remedies may related penile sensory disorders may be compen- evolve from it. sated for by extra stimulation.1 Diminished in¯ux of In this paper we will discuss the subject in the blood will lead to a slower onset of the erection, but following order: may be accepted.
    [Show full text]
  • Customs Tariff - Schedule
    CUSTOMS TARIFF - SCHEDULE 99 - i Chapter 99 SPECIAL CLASSIFICATION PROVISIONS - COMMERCIAL Notes. 1. The provisions of this Chapter are not subject to the rule of specificity in General Interpretative Rule 3 (a). 2. Goods which may be classified under the provisions of Chapter 99, if also eligible for classification under the provisions of Chapter 98, shall be classified in Chapter 98. 3. Goods may be classified under a tariff item in this Chapter and be entitled to the Most-Favoured-Nation Tariff or a preferential tariff rate of customs duty under this Chapter that applies to those goods according to the tariff treatment applicable to their country of origin only after classification under a tariff item in Chapters 1 to 97 has been determined and the conditions of any Chapter 99 provision and any applicable regulations or orders in relation thereto have been met. 4. The words and expressions used in this Chapter have the same meaning as in Chapters 1 to 97. Issued January 1, 2020 99 - 1 CUSTOMS TARIFF - SCHEDULE Tariff Unit of MFN Applicable SS Description of Goods Item Meas. Tariff Preferential Tariffs 9901.00.00 Articles and materials for use in the manufacture or repair of the Free CCCT, LDCT, GPT, UST, following to be employed in commercial fishing or the commercial MT, MUST, CIAT, CT, harvesting of marine plants: CRT, IT, NT, SLT, PT, COLT, JT, PAT, HNT, Artificial bait; KRT, CEUT, UAT, CPTPT: Free Carapace measures; Cordage, fishing lines (including marlines), rope and twine, of a circumference not exceeding 38 mm; Devices for keeping nets open; Fish hooks; Fishing nets and netting; Jiggers; Line floats; Lobster traps; Lures; Marker buoys of any material excluding wood; Net floats; Scallop drag nets; Spat collectors and collector holders; Swivels.
    [Show full text]
  • )&F1y3x PHARMACEUTICAL APPENDIX to THE
    )&f1y3X PHARMACEUTICAL APPENDIX TO THE HARMONIZED TARIFF SCHEDULE )&f1y3X PHARMACEUTICAL APPENDIX TO THE TARIFF SCHEDULE 3 Table 1. This table enumerates products described by International Non-proprietary Names (INN) which shall be entered free of duty under general note 13 to the tariff schedule. The Chemical Abstracts Service (CAS) registry numbers also set forth in this table are included to assist in the identification of the products concerned. For purposes of the tariff schedule, any references to a product enumerated in this table includes such product by whatever name known. Product CAS No. Product CAS No. ABAMECTIN 65195-55-3 ACTODIGIN 36983-69-4 ABANOQUIL 90402-40-7 ADAFENOXATE 82168-26-1 ABCIXIMAB 143653-53-6 ADAMEXINE 54785-02-3 ABECARNIL 111841-85-1 ADAPALENE 106685-40-9 ABITESARTAN 137882-98-5 ADAPROLOL 101479-70-3 ABLUKAST 96566-25-5 ADATANSERIN 127266-56-2 ABUNIDAZOLE 91017-58-2 ADEFOVIR 106941-25-7 ACADESINE 2627-69-2 ADELMIDROL 1675-66-7 ACAMPROSATE 77337-76-9 ADEMETIONINE 17176-17-9 ACAPRAZINE 55485-20-6 ADENOSINE PHOSPHATE 61-19-8 ACARBOSE 56180-94-0 ADIBENDAN 100510-33-6 ACEBROCHOL 514-50-1 ADICILLIN 525-94-0 ACEBURIC ACID 26976-72-7 ADIMOLOL 78459-19-5 ACEBUTOLOL 37517-30-9 ADINAZOLAM 37115-32-5 ACECAINIDE 32795-44-1 ADIPHENINE 64-95-9 ACECARBROMAL 77-66-7 ADIPIODONE 606-17-7 ACECLIDINE 827-61-2 ADITEREN 56066-19-4 ACECLOFENAC 89796-99-6 ADITOPRIM 56066-63-8 ACEDAPSONE 77-46-3 ADOSOPINE 88124-26-9 ACEDIASULFONE SODIUM 127-60-6 ADOZELESIN 110314-48-2 ACEDOBEN 556-08-1 ADRAFINIL 63547-13-7 ACEFLURANOL 80595-73-9 ADRENALONE
    [Show full text]
  • PHARMACEUTICAL APPENDIX to the TARIFF SCHEDULE 2 Table 1
    Harmonized Tariff Schedule of the United States (2020) Revision 19 Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE HARMONIZED TARIFF SCHEDULE Harmonized Tariff Schedule of the United States (2020) Revision 19 Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE TARIFF SCHEDULE 2 Table 1. This table enumerates products described by International Non-proprietary Names INN which shall be entered free of duty under general note 13 to the tariff schedule. The Chemical Abstracts Service CAS registry numbers also set forth in this table are included to assist in the identification of the products concerned. For purposes of the tariff schedule, any references to a product enumerated in this table includes such product by whatever name known.
    [Show full text]
  • (12) Patent Application Publication (10) Pub. No.: US 2012/0115729 A1 Qin Et Al
    US 201201.15729A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2012/0115729 A1 Qin et al. (43) Pub. Date: May 10, 2012 (54) PROCESS FOR FORMING FILMS, FIBERS, Publication Classification AND BEADS FROM CHITNOUS BOMASS (51) Int. Cl (75) Inventors: Ying Qin, Tuscaloosa, AL (US); AOIN 25/00 (2006.01) Robin D. Rogers, Tuscaloosa, AL A6II 47/36 (2006.01) AL(US); (US) Daniel T. Daly, Tuscaloosa, tish 9.8 (2006.01)C (52) U.S. Cl. ............ 504/358:536/20: 514/777; 426/658 (73) Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF 57 ABSTRACT ALABAMA, Tuscaloosa, AL (US) (57) Disclosed is a process for forming films, fibers, and beads (21) Appl. No.: 13/375,245 comprising a chitinous mass, for example, chitin, chitosan obtained from one or more biomasses. The disclosed process (22) PCT Filed: Jun. 1, 2010 can be used to prepare films, fibers, and beads comprising only polymers, i.e., chitin, obtained from a suitable biomass, (86). PCT No.: PCT/US 10/36904 or the films, fibers, and beads can comprise a mixture of polymers obtained from a suitable biomass and a naturally S3712). (4) (c)(1), Date: Jan. 26, 2012 occurring and/or synthetic polymer. Disclosed herein are the (2), (4) Date: an. AO. films, fibers, and beads obtained from the disclosed process. O O This Abstract is presented solely to aid in searching the sub Related U.S. Application Data ject matter disclosed herein and is not intended to define, (60)60) Provisional applicationpp No. 61/182,833,sy- - - s filed on Jun.
    [Show full text]
  • (12) United States Patent (10) Patent No.: US 6,264,917 B1 Klaveness Et Al
    USOO6264,917B1 (12) United States Patent (10) Patent No.: US 6,264,917 B1 Klaveness et al. (45) Date of Patent: Jul. 24, 2001 (54) TARGETED ULTRASOUND CONTRAST 5,733,572 3/1998 Unger et al.. AGENTS 5,780,010 7/1998 Lanza et al. 5,846,517 12/1998 Unger .................................. 424/9.52 (75) Inventors: Jo Klaveness; Pál Rongved; Dagfinn 5,849,727 12/1998 Porter et al. ......................... 514/156 Lovhaug, all of Oslo (NO) 5,910,300 6/1999 Tournier et al. .................... 424/9.34 FOREIGN PATENT DOCUMENTS (73) Assignee: Nycomed Imaging AS, Oslo (NO) 2 145 SOS 4/1994 (CA). (*) Notice: Subject to any disclaimer, the term of this 19 626 530 1/1998 (DE). patent is extended or adjusted under 35 O 727 225 8/1996 (EP). U.S.C. 154(b) by 0 days. WO91/15244 10/1991 (WO). WO 93/20802 10/1993 (WO). WO 94/07539 4/1994 (WO). (21) Appl. No.: 08/958,993 WO 94/28873 12/1994 (WO). WO 94/28874 12/1994 (WO). (22) Filed: Oct. 28, 1997 WO95/03356 2/1995 (WO). WO95/03357 2/1995 (WO). Related U.S. Application Data WO95/07072 3/1995 (WO). (60) Provisional application No. 60/049.264, filed on Jun. 7, WO95/15118 6/1995 (WO). 1997, provisional application No. 60/049,265, filed on Jun. WO 96/39149 12/1996 (WO). 7, 1997, and provisional application No. 60/049.268, filed WO 96/40277 12/1996 (WO). on Jun. 7, 1997. WO 96/40285 12/1996 (WO). (30) Foreign Application Priority Data WO 96/41647 12/1996 (WO).
    [Show full text]
  • Association of Oral Anticoagulants and Proton Pump Inhibitor Cotherapy with Hospitalization for Upper Gastrointestinal Tract Bleeding
    Supplementary Online Content Ray WA, Chung CP, Murray KT, et al. Association of oral anticoagulants and proton pump inhibitor cotherapy with hospitalization for upper gastrointestinal tract bleeding. JAMA. doi:10.1001/jama.2018.17242 eAppendix. PPI Co-therapy and Anticoagulant-Related UGI Bleeds This supplementary material has been provided by the authors to give readers additional information about their work. Downloaded From: https://jamanetwork.com/ on 10/02/2021 Appendix: PPI Co-therapy and Anticoagulant-Related UGI Bleeds Table 1A Exclusions: end-stage renal disease Diagnosis or procedure code for dialysis or end-stage renal disease outside of the hospital 28521 – anemia in ckd 5855 – Stage V , ckd 5856 – end stage renal disease V451 – Renal dialysis status V560 – Extracorporeal dialysis V561 – fitting & adjustment of extracorporeal dialysis catheter 99673 – complications due to renal dialysis CPT-4 Procedure Codes 36825 arteriovenous fistula autogenous gr 36830 creation of arteriovenous fistula; 36831 thrombectomy, arteriovenous fistula without revision, autogenous or 36832 revision of an arteriovenous fistula, with or without thrombectomy, 36833 revision, arteriovenous fistula; with thrombectomy, autogenous or nonaut 36834 plastic repair of arteriovenous aneurysm (separate procedure) 36835 insertion of thomas shunt 36838 distal revascularization & interval ligation, upper extremity 36840 insertion mandril 36845 anastomosis mandril 36860 cannula declotting; 36861 cannula declotting; 36870 thrombectomy, percutaneous, arteriovenous
    [Show full text]
  • Les Femmes Peuvent Prendre Du Viagra * Achat De Viagra En
    Viagra est indiquée pour le traitement de la dysfonction érectile masculine. >>> ORDER NOW <<< Les femmes peuvent prendre du viagra Tags: cialis ou viagra acheter vrai ou faux viagra risques avec viagra acheter du viagra sans ordonnance en suisse danger du faux viagra comment bien prendre viagra le prix du viagra en pharmacie au maroc les effets indesirable du viagra que ce que viagra de gaulle contre le viagra achat viagra internet doctissimo commande viagra belgique peut on avoir du viagra en pharmacie sans ordonnance comment prendre sildenafil pfizer nitrates and viagra interaction ordonnance ou pas pour viagra notice demballage viagran quels sont les effets du viagra quelle quantité de viagra prendre peut on acheter viagra en pharmacie sans ordonnance comment avoir le viagra site sur achat viagra nitrates viagra can deadly combination Recession quest ce qui peut remplacer le viagra review am astonishingly forgetful. Some things said caffeine was fine to consume (in drinks, food, etc) while on the med, others said caffeine decreased the effects of the med. Features of this disorder include dysphonia, dysarthria, and loss of pain and temperature over the ipsilateral face and contralateral body. Jeg vil også erklære, at du forlader soap ud. If you feel very bored when waiting for something or someone (a bus, your friend, your kids), distract yourself with a book, magazine, or crossword puzzle. The celexa is longer acting and must build in the system over time in order to work for anxiety. Medscape is the leading online destination for healthcare professionals seeking clinical information. Paxil over time increased my appetite but i think that is because les femmes peuvent prendre du viagra made me tired and lethargic, they did not increase appetite, in fact in the first few months they curbed it right down.
    [Show full text]
  • 2019 Instrumentation and Consumable Catalog 2 INSTRUMENTATION and CONSUMABLE CATALOG
    PRODUCT CATALOG 2019 Instrumentation and Consumable Catalog 2 INSTRUMENTATION AND CONSUMABLE CATALOG Resolvex® A200 Part Numbers: A200 96: 253-1160 Resolvex® A200 96 Resolvex A200 Standalone work station for automated sample preparation. The compact benchtop offers the one stop solution for automating sample preparation utilizing creation of multiple work flows, and programmable dispensing of up to 11 solvents. Along with its innovative positive pressure system leading to clean samples, improving accuracy, throughput and enhancing the Life time of your analytical instrument. The A200 comes with an easy to use touch screen interface allowing for easy set up of multiple work flows. In addition the light curtain safety feature will release gas pressure when manifold is activated to prevent any injuries. INSTRUMENTATION AND CONSUMABLE CATALOG 3 Resolvex® A100 Part Numbers: A100 96: 253-0019 A100 48: 253-0014 Resolvex® A100 Standalone work station for automated sample preparation. The compact benchtop offers the one stop solution for automating sample preparation utilizing creation of multiple work flows, and programmable dispensing of up to 11 solvents. Along with its innovative positive pressure system leading to clean samples, improving accuracy, throughput and enhancing the Life time of your analytical instrument. The A100 comes in 96 and 4 configuration allowing for for automated Work Flow solutions in multiple SPE formats. 4 INSTRUMENTATION AND CONSUMABLE CATALOG Resolvex® M10 96/M10 96 XT/M10 48 Part Numbers: M10 96 XT: 288-0006 M10 96: 288-0001 M10 48: 289-0004 Resolvex® M10 Standalone work station for Positive Pressure solid phase extraction. The manual Resolvex M10 48 and 96 are positive pressure manifold for 1, 3, and 6 ml cartridges, or 1ml 96 well plates.
    [Show full text]
  • The Use of Stems in the Selection of International Nonproprietary Names (INN) for Pharmaceutical Substances
    WHO/PSM/QSM/2006.3 The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances 2006 Programme on International Nonproprietary Names (INN) Quality Assurance and Safety: Medicines Medicines Policy and Standards The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances FORMER DOCUMENT NUMBER: WHO/PHARM S/NOM 15 © World Health Organization 2006 All rights reserved. Publications of the World Health Organization can be obtained from WHO Press, World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland (tel.: +41 22 791 3264; fax: +41 22 791 4857; e-mail: [email protected]). Requests for permission to reproduce or translate WHO publications – whether for sale or for noncommercial distribution – should be addressed to WHO Press, at the above address (fax: +41 22 791 4806; e-mail: [email protected]). The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted lines on maps represent approximate border lines for which there may not yet be full agreement. The mention of specific companies or of certain manufacturers’ products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters.
    [Show full text]