Supplementary Table 4. Description of historical controls (Pesonen et al. Gene Ther 2010;17:892-904) treated with unarmed oncolytic adenovirus Ad5/3-cox2L-D24. ID Age Tumor WHOa Viral Dose Prior Therapies (Sex) type (VP) K2 48 NSCLC 1 2.6x10e9 Radiation therapy to vertebral column and sternum, followed by (M) cisplatin+taxotere x3 and pemetrexed x5. Erlotinib for ca 6 months. Recently radiation to pelvic girdle and head. S4 50 MFH 4 6x10e9 Operated. Adjuvant doxorubicin+ ifosfamide x6. Lung metastases (M) operated. Doxorubicin+ ifosfamide repeated. Radiation therapy. H5 60 pancreatic 2 1x10e10 Gemcitabine+capecitabine, chemoradiotherapy with gemcitabine, (M) cancer gemcitabine+erlotinib, capecitabine+oxaliplatin. C6 46 colon 1 6x10e9 Operated. Adjuvant capecitabine x6. Capecitabine+irinotecan, (M) cancer capecitabine+bevacizumab, 5-fluorouracil+ leucovorin+ oxaliplatin, irinotecan+gemcitabine+bevacizumab H7 61 pancreatic 1 9x10e9 Operated. Adjuvant gemcitabine for 6 months. Capecitabine+ (F) cancer oxaliplatin. O9 61 ovarian 1 2x10e10 Operated. Paclitaxel+carboplatin, gemcitabine+carboplatin, (F) cancer single-agent gemcitabine, liposomal doxorubicin, topotecan. R10 43 breast 2 5.3x10e10 Operated: hysterectomy, salpingo-oophorectomy+ mastectomy. (F) cancer Adjuvant cyclophosphamide+epirubicin+5-fluorouracil x3, docetaxel x3. Capecitabine+docetaxel, cyclophosphamide+ epirubicin+5-fluorouracil x8, epirubicin x11, carboplatin+ gemcitabine x8, vinorelbine+methotrexate+5-fluorouracil x4, cyclophosphamide+liposomal doxorubicin. Radiation to sternum and head. G11 49 gastric 2 2x10e10 Operated. Chemoradiotherapy+ 5-fluorouracil. Capecitabine+ (F) cancer oxaliplatin+ epirubicin, single-agent docetaxel, irinotecan+ gemcitabine+ erlotinib+ bevacizumab, docetaxel+erlotinib+ bevacizumab. C13 62 colon 1 5x10e10 Operated. Leucovorin+5-fluorouracil+irinotecan, capecitabine+ (F) cancer oxaliplatin, capecitabine+bevacizumab, etuximab+ leucovorin+ 5- fluorouracil+irinotecan, and again capecitabine+bevacizumab. O16 62 fallobian 2 1x10e11 Operated. Paclitaxel+carboplatin, single-agent gemcitabine, (F) tube c. liposomal doxorubicin, topotecan, docetaxel, single-agent paclitaxel, vinorelbine, etoposide, oxaliplatin+bevacizumab+ erlotinib, single-agent erlotinib. C17 56 colon 1 1.2x10e11 Operated. 5-fluorouracil, 5-fluorouracil+leucovorin+oxaliplatin, (M) cancer gemcitabine+irinotecan+carmofur (HCFU)+leucovorin, bevacizumab+erlotinib. P20 74 prostate 2 2x10e11 Leuprorelin. Radiation. Bicalutamide. Bicalutamide+ leuprorelin. (M) cancer Flutamide. Radiation. Docetaxel+zoledronic acid, docetaxel+ zoledronic acid+ estramustine, zoledronic acid +epirubicin. N21 5 neuro- 0 1x10e11 Vincristine + cisplatin + etoposide + cyclophosphamide alternated (M) blastoma with vincristine + carboplatin + etoposide+ cyclophosphamide. Doxorubicin + etoposide + iphosphamide. Intensive chemotherapy and autologous stem cell transplant. Oral 13-cis- retinoic acid. H22 62 pancreatic 2 2x10e11 Operated. Gemcitabine, chemoradiotherapy with gemcitabine. (F) cancer O24 53 ovarian 1 2x10e11 Operated, postoperative chemotherapy. Relapse 6 years ago, (F) cancer chemotherapy. Paclitaxel, paclitaxel+carboplatin, single-agent carboplatin, liposomal doxorubicin, topotecan, etoposide. O25 48 ovarian 2 2x10e11 Operated. Paclitaxel + carboplatin. Recurrence, debulking (F) cancer surgery, liposomal doxorubicin, topotecan, gemcitabine, treosulfan + bevacizumab, paclitaxel + bevacizumab. P27 70 prostate 2 3x10e11 Neoadjuvant hormone therapy, radiation therapy. Leuprorelin, (M) cancer bicalutamide, leuprorelin again, docetaxel. Radiation therapy. Estramustine, flutamide, bicalutamide again, zoledronic acid. O37 54 ovarian 2 3x10e11 Operated. Paclitaxel+carboplatin, gemcitabine+carboplatin, (F) cancer cisplatin+gemcitabine. a, Performance status at the time of treatment; VP, viral particles; NSCLC, non-small cell lung cancer; MFH, malignant fibrous histiocytoma;