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Prediction of Enophthalmos by Computed 618 Britishjournal ofOphthalmology 1994; 78: 618-620 Prediction of enophthalmos by computed tomography after 'blow out' orbital fracture Br J Ophthalmol: first published as 10.1136/bjo.78.8.618 on 1 August 1994. Downloaded from R W Whitehouse, M Batterbury, A Jackson, J L Noble Abstract In 11 patients with blow out fracture of the orbit, measurement of orbital volume using computed tomography (CT) more than 20 days after injury correlated weli with enophthalmos measured from the same scans (r=0.87, p<0-001, SEE 0-63 mm), with a 1 cm3 increase in orbital volume causing 0*8 mm ofenophthal- mos. This confirms the cause of enophthalmos after blow out fracture to be increase in orbital volume rather than fat atrophy or fibrosis. In a further 25 patients scanned within 20 days of injury the degree of enophthalmos was less marked than would be predicted from the orbital volume measurement. This was prob- ably because of the presence of oedema, haemorrhage, or both behind the globe which would prevent immediate development of CT measurement of enophthalmos. orbital Figure I Transaxial low dose CT image ofthe orbits. A volume within 20 days ofinjury may predict the medial wall blow outfracture ofthe right orbit is present. The final degree ofenophthalmos and identify those cross sectional area ofeach orbit has been measuredfor patients at risk of late enophthalmos, allowing orbital volume calculation. appropriate early surgical intervention. (BrJ Ophthalmol 1994; 78: 618-620) medial wall and floor fractures, the latter associ- ated with malar fractures in two cases. All scans were performed on a GE9800 general purpose Enophthalmos is a common result of 'blow out' CT scanner (General Electric, Milwaukee, USA) fracture of the orbit. It is now widely accepted using a low radiation dose dynamic transaxial that enophthalmos results from an increase in scan technique as previously described"' http://bjo.bmj.com/ volume of the bony orbit with consequent pos- (120 kVp, 40 mA, 2 s scan time, 3 mm con- terior displacement of the globe as the retro- tiguous sections). Each orbital volume was mea- bulbar fat and muscles are displaced into the sured on the CT console: On each image the bony blow out defect.' 2 Other possible factors such as outline of each orbit was traced out, the anterior fat atrophy or fibrosis3 have not been demon- limit being closed with a line joining the strated to contribute to a significant degree. zygomaticofrontal processes (Fig 1). The areas of Enophthalmos may be both cosmetically un- these outlines were then measured and summed on October 1, 2021 by guest. Protected copyright. acceptable and may cause diplopia by interfering for each orbit. Orbital volume was calculated with extraocular muscle function.4 Enoph- from the summed area multiplied by the section thalmos may not develop immediately after trauma and its onset may occasionally be delayed for 2 months or more."6 Early surgical interven- tion can improve the outcome67 but identifying those patients at risk of late enophthalmos is problematic. Computed tomography (CT) has been used to measure both orbital volume89 and enoph- Department of Clinical thalmos' in blow out fractures but a specific in Radiology, Manchester vivo relation between these measurements has Royal Infirmary, Oxford not been previously defined. The current study Road, Manchester M13 9WL aims to evaluate the relation between orbital R W Whitehouse volume and enophthalmos following blow out A Jackson fracture. Manchester Royal Eye Hospital, Oxford Road, Manchester M13 9WH Patients and methods M Batterbury J The CT examinations of 36 consecutive patients L Noble attending the department ofdiagnostic radiology Correspondence to: Dr R W Whitehouse. for assessment of orbital blow out fractures were Figure 2 The position ofeach globe is measuredfrom the Accepted for publication reviewed. There were 13 orbital floor fractures, zygomaticofrontal process baseline to the back ofthe lens II April 1994 three medial wall fractures, and 21 combined (distances I and 2). Prediction ofenophthalmos by computed tomography after 'blow out' orbitalfracture 619 4 Figure 3 also demonstrates that a large propor- tion of patients (14/36), particularly those with 3 smaller blow out fracture volumes had negative enophthalmos (exophthalmos) at the time of Br J Ophthalmol: first published as 10.1136/bjo.78.8.618 on 1 August 1994. Downloaded from E 2 scanning. When only scans performed more than 20 days E0 1 0 after injury were included, the correlation -cE 0 improved with a similar slope but less negative intercept value to the regression formula (Fig 3, regression line 2): CL -1 c UJ E=0-77V - 0-68 (2) -2 r=0-87, p<0001, SEE 0-63 mm, n=ll In order to demonstrate the dependence on time -3 after injury of the relation between orbital -4 volume and enophthalmos, formula (2) was used -1 0 2 3 4 5 to calculate the expected degree ofenophthalmos from the measured blow out fracture volume for Blow out fracture volume (cm3) all 36 subjects. Unexplained enophthalmos was Figure 3 Relation between blow outfracture volume calculated as measured enophthalmos minus and enophthalmos. Line I is thickness. Both the precision and accurac:y ofthis expected enophthalmos. Unexplained enoph- the regressionfor all 36 data measurement have been previously demon- thalmos was then plotted against time since points, line 2 isfor points strated to be better than 2%." The bllow out injury (Fig 4), using a logarithmic time axis to marked (0), scanned more the than 20 days after injury. fracture size was assumed to be discirepancy clarify the distribution of data points within 20 in volume between the traumatised and normal days ofinjury. orbit volumes, as right and left orbital vol[umes in an individual normally lie within 0 65 cm'3 ofeach other. " 12 Globe position was measured firom the Discussion same zygomaticofrontal process baselin(e to the The results of this study confirm that enoph- posterior surface ofthe lens in each orbit (Fig 2), thalmos after blow out fracture of the, orbit is enophthalmos being the normal eye edistance linearly related to the increase in volume of the minus the traumatised eye distance. blown out orbit. This relation is consistent in injuries between 20 days and 2 years old, with each cm3 increase in volume causing approxi- STATISTICAL TESTS mately 0-77 mm of enophthalmos. Injuries less The relation between enophthalmos andI orbital than 20 days old have a similar regression line volume discrepancy was assessed using.Pearson slope (approximately 0-8 mm per cm') but an correlation coefficients. intercept of -1-67, indicating a coexisting ten- dency for relative exophthalmos in the trau- matised orbit. This should be expected; it http://bjo.bmj.com/ Results presumably represents the effect of soft tissue A highly significant correlation between b)low out swelling in the retrobulbar soft tissues counter- fracture volume and enophthalmos was demon- acting the increase in orbital volume caused by strated in the entire group of 36 subjects (Fig 3, the blow out. Calculating unexplained enoph- regression line 1): thalmos quantifies the effect of this soft tissue E=0-82V- 1-67 (1) swelling, which can then be plotted against time Figure 4 Relation between r=0-74, p<0001, SEE 1-1 mm, n==36 since injury (Fig 4). This graph demonstrates on October 1, 2021 by guest. Protected copyright. unexplained enophthalmos that enophthalmos may be less marked than and time since injury. A log,, where expected by up to 3 mm within 20 days of injury. time scale has been used to E = enophthalmos (mm) Thus up to 3 mm of enophthalmos may be clarify the distribution of = data points. The broken line V blow out fracture volume (cm'3) obscured by retrobulbar soft tissue swelling after indicates 20 days post- SEE = standard error of estimate blow out fracture and this effect may still be injury. apparent 20 days after injury. The volume change of 1 cm' required to produce 0-8 mm of globe movement is greater than that predicted by E a an in vitro model" where a 2 8% volume change E * (approximately 0 56 cm') caused 1 mm of globe Un . 0 a movement. This discrepancy may reflect some E I 0 - resistance to movement of the globe in vivo, * perhaps because of its suspensory ligament - * ~ IE attachments to the bony orbit.'4 Alternatively, it 0 -1 c may be due to the compartmentalisation of 0 'am I.| orbital fat, some of which may be displaced by a . -2 * m blow out fracture, without causing globe dis- placement."S The cause of this discrepancy is of x * * U less practical importance than the recognition of c -3 - ~~~~~* the in vivo relation between orbital volume I change and globe position; this may be used to -4 assess the need for surgery or to estimate the 1 10 100 1000 volume of replacement material required to Time since injury (days log1o scale) reduce enophthalmos. 620 Whitehouse, Batterbury, _Jackson, Noble In a previous retrospective analysis we have influence of time or repair and fracture size. Ophthalmology 1983; 90: 1066-70. demonstrated that surgery is more likely to be 7 Converse JM, Smith B. On the treatment of blow out fractures performed in patients with larger volume blow of the orbit. Plast Reconst Surg 1978; 62: 100-4. 8 Forbes G, Gehring DG, Gorman CA, Brennan MD, Jackson out fractures,6 confirming previous findings.'7 IT. Volume measurements of normal orbital structures by Br J Ophthalmol: first published as 10.1136/bjo.78.8.618 on 1 August 1994. Downloaded from The current study demonstrates that measure- computed tomographic analysis. Amj Roentgenol 1985; 145: 149-54. ment of orbital volume within 20 days of injury 9 Whitehouse RW, Jackson A.
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