DOCSLIB.ORG

Qnas with Pardis Sabeti QNAS

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Qnas with Pardis Sabeti QNAS QNAS QnAs with Pardis Sabeti QNAS Sandeep Ravindran, Science Writer Pardis Sabeti received the 2017 National Academy of and really understand how the Sciences Richard Lounsbery Award in biology for her malaria parasites are changing groundbreaking work in computational genetics and to survive against our immune global health. A professor at Harvard University, the system and the drug pressures Broad Institute, and the Howard Hughes Medical we put on them. Institute, Sabeti has developed computational meth- ods to detect genetic variants under natural selection, PNAS: In 2014 you published and has applied these methods to both humans and alandmarkScience article on pathogens. She has conducted pioneering genomic the human-to-human transmis- analyses of Ebola and Lassa viruses, and her work sion of the Ebola virus (4). How played an important role in tracking Ebola transmis- did that article come about, sion during the 2014 outbreak in West Africa. Sabeti and what was its significance? recently spoke with PNAS about her efforts to combat emerging diseases. Sabeti: In 2014 our group was working with our collaborators PNAS: How did you first get interested in computational in Sierra Leone and in Nigeria genetics? on a disease called Lassa fe- ver, which is a hemorrhagic ’ Sabeti: I ve always really liked math and solving puz- fever virus much like Ebola. Pardis Sabeti. Photograph by Morgan Miller zles with math. I really enjoyed my math courses in We had gotten a grant to set and courtesy of Pardis Sabeti. college at MIT [Massachusetts Institute of Technol- up surveillance in West Africa ogy], but I also wanted to impact human health. Ge- for infectious diseases. Star- netics really struck me because it is biology as tlingly, just at that time the Ebola outbreak was mathematical information. So it had all of the compo- declared in Guinea just across the border, and our nents of what I wanted to do. collaborators in Sierra Leone found themselves at the epicenter of the outbreak. We were trying to help PNAS: What have been some of the key applications them rapidly do diagnoses and call attention to the of the computational methods you developed to problem. We had developed a number of techniques detect genetic variants under evolutionary selection to sequence Lassa fever over the last few years, and in humans and in pathogens? we were able to use them to sequence the Ebola virus and generate the data in a matter of weeks (4). It Sabeti: In my graduate studies I really became in- showed that we could release this kind of data in terested in how we can mine data from the human real-time, and that we could potentially have an un- genome and find footprints of ancient evolutionary derstanding of transmission as well as identifying mu- adaption both in humans and in pathogens (1–3). Es- tations in the virus that might impact diagnostics and sentially, if a variant is important for the survival or re- therapies. The fact that we could show with data that productive success of an organism, it will be likely to be the virus was mutating also provided a greater push to passed on to that person’s children and to their child- move quickly. ren’s children, and as a result it will spread in the pop- ulation. I developed computational methods that allow PNAS: How are you continuing to combat pandemics, you to find the footprints of ancient evolutionary pres- such as Ebola and Lassa fever? sure and then used them to pinpoint specific mutations that have an important biological impact. The key ap- Sabeti: Over the course of the last few years, we’ve set plication of these kinds of methods is to find those up sequencing machines in Sierra Leone, Senegal, functional variations that are important for the survival and Nigeria, and we’ve partnered with colleagues of humans or the microbes that infect humans. These in Liberia to help their sequencing efforts there. Ev- methods have been used to track down variations in erysummerwebringsomeonefromeachofthose humans that are important in resistance to infectious countries to receive training in advanced sequenc- diseases, such as malaria. Interestingly, we can also ap- ing.Wealsohaveabout20peoplewhoareherein ply these same tools to track drug resistance in malaria summer getting foundational learning in molecular www.pnas.org/cgi/doi/10.1073/pnas.1714015114 PNAS Early Edition | 1of2 Downloaded by guest on October 2, 2021 diagnostics for these viruses. We continue to build PNAS: How have your diverse interests outside of the better diagnostics and an understanding of how laboratory (such as being the lead singer of the rock these viruses work and of host responses to these band Thousand Days) influenced your approach to viruses. science and research? PNAS: What has surprised you the most during your Sabeti: I do have a number of passions, music being one research career? of the greatest ones. I often say that people underesti- mate the creativity that you need in science, and the rigor Sabeti: One of the biggest surprises was the discovery that you need in music or other creative endeavors. Both that Lassa fever might be important in our history. I was require you to be able to start with an exploratory phase, scanning the human genome with the International where you discover and think and imagine all of the Haplotype Map project using the test I had developed things that are possible, but then to get that out into the to try to find footprints of ancient adaptation (5–7). The world it takes a large amount of rigor, either to produce a first time I did this, the strongest signal we found was for a gene that’s critical for infection with Lassa virus. It was song with 80 tracks all in the right way, or to do all of a really exciting moment, recognizing that actually this the right controls and to test a hypothesis carefully. Music virus is circulating in West Africa, where we discovered is particularly important to me because in West Africa, the signal of selection, and might have been around where we work, music is also really meaningful for them. for a really long time. I think that was a major turning I sing with my African colleagues and write music with point in my career, so that’s probably one of the most them, and we even recently released an album of music meaningful surprises. together. 1 Sabeti PC, et al. (2006) Positive natural selection in the human lineage. Science 312:1614–1620. 2 Neafsey DE, et al. (2008) Genome-wide SNP genotyping highlights the role of natural selection in Plasmodium falciparum population divergence. Genome Biol 9:R171. 3 Park DJ, et al. (2012) Sequence-based association and selection scans identify drug resistance loci in the Plasmodium falciparum malaria parasite. Proc Natl Acad Sci USA 109:13052–13057. 4 Gire SK, et al. (2014) Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak. Science 345:1369–1372. 5 International HapMap Consortium (2003) The International HapMap Project. Nature 426:789–796. 6 Andersen KG, et al. (2012) Genome-wide scans provide evidence for positive selection of genes implicated in Lassa fever. Philos Trans R Soc Lond B Biol Sci 367:868–877. 7 Sabeti PC, et al.; International HapMap Consortium (2007) Genome-wide detection and characterization of positive selection in human populations. Nature 449:913–918. 2of2 | www.pnas.org/cgi/doi/10.1073/pnas.1714015114 Ravindran Downloaded by guest on October 2, 2021.
Load more

Recommended publications
  • Inside the Ebola Wars ­ the New Yorker
    4/13/2017 Inside the Ebola Wars ­ The New Yorker A REPORTER AT LARGE OCTOBER 27, 2014 I﹙UE THE EBOLA WARS How genomics research can help contain the outbreak. By Richard Preston Pardis Sabeti and Stephen Gire in the Genomics Platform of the Broad Institute of M.I.T. and Harvard, in Cambridge, Massachusetts. They have been working to sequence Ebola’s genome and track its mutations. he most dangerous outbreak of an emerging infectious disease since the appearance of H.I.V., in the early nineteen-eighties, seems to have begun on DTecember 6, 2013, in the village of Meliandou, in Guinea, in West Africa, with the death of a two-year-old boy who was suffering from diarrhea and a fever. We now know that he was infected with Ebola virus. The virus is a parasite that lives, normally, in some as yet unidentified creature in the ecosystems of equatorial Africa. This creature is the natural host of Ebola; it could be a type of fruit bat, or some small animal that lives on the body of a bat—possibly a bloodsucking insect, a tick, or a mite. Before now, Ebola had caused a number of small, vicious outbreaks in central and eastern Africa. Doctors and other health workers were able to control the outbreaks quickly, and a belief developed in the medical and scientific communities that Ebola was not much of a threat. The virus is spread only through direct contact with blood and bodily fluids, and it didn’t seem to be mutating in any significant way.
    [Show full text]
  • News Harvard University
    THE CENTER FOR MIDDLE EASTERN STUDIES, NEWS HARVARD UNIVERSITY SPRING 2015 1 LETTER FROM THE DIRECTOR A message from William Granara 2 SHIFTING TOWARDS THE ARABIAN PENINSULA Announcing a new lecture series 3 NEWS AND NOTES Updates from faculty, students and visiting researchers 12 EVENT HIGHLIGHTS Spring lectures, workshops, and conferences LETTER FROM THE DIRECTOR SPRING 2015 HIGHLIGHTS I’M HAPPY TO REPORT THAT WE ARE DRAWING TO THE CLOSE OF AN ACADEMIC YEAR FULL OF ACTIVITY. CMES was honored to host a considerable number of outstanding lectures this year by eminent scholars from throughout the U.S. as well as from the Middle East and Europe. I mention only a few highlights below. Our new Middle Eastern Literatures initiative was advanced by several events: campus visits by Arab novelists Mai Nakib (Kuwait), Ahmed Khaled Towfik (Egypt), and Ali Bader (Iraq); academic lectures by a range of literary scholars including Hannan Hever (Yale) on Zionist literature and Sheida Dayani (NYU) on contemporary Persian theater; and a highly successful seminar on intersections between Arabic and Turkish literatures held at Bilgi University in Istanbul, which included our own Professor Cemal Kafadar, several of our graduate students, and myself. In early April, CMES along with two Harvard Iranian student groups hosted the first Harvard Iranian Gala, which featured a lecture by Professor Abbas Milani of Stanford University and was attended by over one hundred guests from the broader Boston Iranian community. Also in April, CMES co-sponsored an international multilingual conference on The Thousand and One Nights with INALCO, Paris. Our new Arabian Peninsula Studies Lecture Series was inaugurated with a lecture by Professor David Commins of Dickinson College, and we are happy to report that this series will continue in both the fall and spring semesters of next year thanks to the generous support of CMES alumni.
    [Show full text]
  • Outbreak of SARS-Cov-2 Infections, Including COVID-19 Vaccine
    Morbidity and Mortality Weekly Report Outbreak of SARS-CoV-2 Infections, Including COVID-19 Vaccine Breakthrough Infections, Associated with Large Public Gatherings — Barnstable County, Massachusetts, July 2021 Catherine M. Brown, DVM1; Johanna Vostok, MPH1; Hillary Johnson, MHS1; Meagan Burns, MPH1; Radhika Gharpure, DVM2; Samira Sami, DrPH2; Rebecca T. Sabo, MPH2; Noemi Hall, PhD2; Anne Foreman, PhD2; Petra L. Schubert, MPH1; Glen R. Gallagher PhD1; Timelia Fink1; Lawrence C. Madoff, MD1; Stacey B. Gabriel, PhD3; Bronwyn MacInnis, PhD3; Daniel J. Park, PhD3; Katherine J. Siddle, PhD3; Vaira Harik, MS4; Deirdre Arvidson, MSN4; Taylor Brock-Fisher, MSc5; Molly Dunn, DVM5; Amanda Kearns5; A. Scott Laney, PhD2 On July 30, 2021, this report was posted as an MMWR Early Massachusetts, that attracted thousands of tourists from across Release on the MMWR website (https://www.cdc.gov/mmwr). the United States. Beginning July 10, the Massachusetts During July 2021, 469 cases of COVID-19 associated Department of Public Health (MA DPH) received reports of with multiple summer events and large public gatherings in an increase in COVID-19 cases among persons who reside in a town in Barnstable County, Massachusetts, were identified or recently visited Barnstable County, including in fully vac- among Massachusetts residents; vaccination coverage among cinated persons. Persons with COVID-19 reported attending eligible Massachusetts residents was 69%. Approximately densely packed indoor and outdoor events at venues that three quarters (346; 74%) of cases occurred in fully vac- included bars, restaurants, guest houses, and rental homes. On cinated persons (those who had completed a 2-dose course July 3, MA DPH had reported a 14-day average COVID-19 of mRNA vaccine [Pfizer-BioNTech or Moderna] or had incidence of zero cases per 100,000 persons per day in residents received a single dose of Janssen [Johnson & Johnson] vac- of the town in Barnstable County; by July 17, the 14-day cine ≥14 days before exposure).
    [Show full text]
  • Michael S. Brown, MD
    DISTINGUISHED PHYSICIANS AND Michael S. Brown, M.D. Sir Richard Roberts, Ph.D. Winner, 1985 Nobel Prize in Physiology or Medicine Winner, 1993 Nobel Prize in Physiology or Medicine MEDICAL SCIENTISTS MENTORING Winner, 1988 Presidential National Medal of Science A globally prominent biochemist and molecular biologist, DELEGATES HAVE INCLUDED... Dr. Brown received the world’s most prestigious medical Dr. Roberts was awarded the Nobel Prize for his prize for his work describing the regulation of the groundbreaking contribution to discovering RNA splicing. cholesterol metabolism. His work laid the foundation for Dr. Roberts is dedicating his future research to GMO crops the class of drugs now called statins taken daily by more than 20 million and food sources, and demonstrating the effect they have on humanity. — GRANDg MASTERS — people worldwide. Ferid Murad, M.D., Ph.D. Mario Capecchi, Ph.D. Boris D. Lushniak, M.D., M.P.H Winner, 1998 Nobel Prize in Physiology or Medicine Academy Science Director The Surgeon General of the United States (acting, 2013-2014) Winner, 2007 Nobel Prize in Physiology or Medicine A world-renowned pioneer in biochemistry, Dr. Murad’s Winner, 2001 National Medal of Science Rear Admiral Lushniak, M.D., M.P.H., was the United award-winning research demonstrated that nitroglycerin Winner, 2001 Lasker Award States’ leading spokesperson on matters of public health, and related drugs help patients with heart conditions by Winner, 2003 Wolf Prize in Medicine overseeing the operations of the U.S. Public Health Service releasing nitric oxide into the body, thus relaxing smooth Mario Capecchi, Ph.D., a biophysicist, is a Distinguished Commissioned Corps, which consists of approximately muscles by elevating intracellular cyclic GMP, leading to vasodilation and Professor of Human Genetics at the University of Utah School of Medicine.
    [Show full text]
  • Arxiv:2003.13670V4 [Cs.CY] 3 Apr 2020 IV Program
    Anonymous Collocation Discovery: Harnessing Privacy to Tame the Coronavirus∗ Ran Canetti† Ari Trachtenberg‡ Mayank Varia§ Boston University April 7, 2020 Abstract Successful containment of the Coronavirus pandemic rests on the ability to quickly and reliably identify those who have been in close proximity to a contagious individual. Existing tools for doing so rely on the collection of exact location information of individuals over lengthy time periods, and combining this information with other personal information. This unprecedented encroachment on individual privacy at national scales has created an outcry and risks rejection of these tools. We propose an alternative: an extremely simple scheme for providing fine-grained and timely alerts to users who have been in the close vicinity of an infected individual. Crucially, this is done while preserving the anonymity of all individuals, and without collecting or storing any personal information or location history. Our approach is based on using short-range communication mechanisms, like Bluetooth, that are available in all modern cell phones. It can be deployed with very little infrastructure, and incurs a relatively low false-positive rate compared to other collocation methods. We also describe a number of extensions and tradeoffs. We believe that the privacy guarantees provided by the scheme will encourage quick and broad voluntary adoption. When combined with sufficient testing capacity and existing best practices from healthcare professionals, we hope that this may significantly reduce the infection rate. To avoid confusion, we stress that this work does not propose any direct medical treatment. arXiv:2003.13670v4 [cs.CY] 3 Apr 2020 Rather, it proposes a way to pool together information from the community in order to help (a) direct medical personnel in how to best allocate and use testing resources, and (b) direct individuals as to when to get tested and self-quarantine.
    [Show full text]
  • For Young Scientists
    THE BLAVATNIK AWARDS For Young Scientists N E R AT I O N O T G E F S C E X I E N N T E I F H I C T G I N I N N V O I V R A D T I O N 2021 The Blavatnik Awards for Young Scientists honor exceptional young scientists and engineers by celebrating their extraordinary achievements, recognizing outstanding promise, and accelerating innovation through unrestricted funding. Table of Contents Key Features ..............................................................................................................................................4 Our History ................................................................................................................................................6 Blavatnik Regional Awards ...................................................................................................................8 Blavatnik National Awards .................................................................................................................10 Blavatnik Awards in the United Kingdom ......................................................................................12 Blavatnik Awards in Israel................................................................................................................... 14 Blavatnik Science Scholars ................................................................................................................. 16 In the News ............................................................................................................................................. 18
    [Show full text]
  • Qnas with Pardis Sabeti QNAS
    QNAS QnAs with Pardis Sabeti QNAS Sandeep Ravindran, Science Writer Pardis Sabeti received the 2017 National Academy of and really understand how the Sciences Richard Lounsbery Award in biology for her malaria parasites are changing groundbreaking work in computational genetics and to survive against our immune global health. A professor at Harvard University, the system and the drug pressures Broad Institute, and the Howard Hughes Medical we put on them. Institute, Sabeti has developed computational meth- ods to detect genetic variants under natural selection, PNAS: In 2014 you published and has applied these methods to both humans and alandmarkScience article on pathogens. She has conducted pioneering genomic the human-to-human transmis- analyses of Ebola and Lassa viruses, and her work sion of the Ebola virus (4). How played an important role in tracking Ebola transmis- did that article come about, sion during the 2014 outbreak in West Africa. Sabeti and what was its significance? recently spoke with PNAS about her efforts to combat emerging diseases. Sabeti: In 2014 our group was working with our collaborators PNAS: How did you first get interested in computational in Sierra Leone and in Nigeria genetics? on a disease called Lassa fe- ver, which is a hemorrhagic ’ Sabeti: I ve always really liked math and solving puz- fever virus much like Ebola. Pardis Sabeti. Photograph by Morgan Miller zles with math. I really enjoyed my math courses in We had gotten a grant to set and courtesy of Pardis Sabeti. college at MIT [Massachusetts Institute of Technol- up surveillance in West Africa ogy], but I also wanted to impact human health.
    [Show full text]
  • Science News
    COVID-19 Lessons From Colleges | Impostor Fossils MAGAZINE OF THE SOCIETY FOR SCIENCE s FEBRUARY 27, 2021 Solar Storms Scientists amp up efforts to protect Earth from what the sun throws at us cover.indd 1 2/10/21 1:52 PM Cognitive Behavioral Therapy for Daily Life Taught by Professor Jason M. Satterfi eld TIME ED O , T FF I E IM R L 1. A CBT Toolbox: Toward Wise Living 70% 2. Laying a Foundation: Assessments and Goals 1 O off 3. Behavioral Activation: Potent Mood Boosters R H C DE R 4. Advanced Behavioral Techniques R B MA Y 5. Capturing Thoughts and Making Connections 6. Cognitive Restructuring and Thought Records 7. Worry, Rumination, and Sticky Thoughts 8. Digging Deeper: Rules and Core Beliefs 9. Toolbox in Action: Stress and Assertiveness 10. Understanding and Managing Emotions 11. Key Steps to Solving Problems 12. Grief, Sadness, and Depression 13. Panic Attacks and Anxiety 14. Addiction and Pain Medications 15. Embracing Imperfection 16. Beating Procrastination 17. Soothing Rejection, Promoting Connection 18. Early Childhood Trauma and Neglect 19. Managing Chronic Disease 20. Coping with Chronic Pain 21. How to End Insomnia and Finally Sleep A Powerful Way to Take 22. CBT for the Beginning of the End of Life 23. Expanding CBT with Technology Control of Your Life 24. Reclaiming and Rewriting Our Stories Why is life so challenging? Life presents daily challenges such as difficult coworkers, chronic pain, marital conflicts, grief, parenting issues, and Cognitive Behavioral Therapy for Daily Life Course no. 9661 | 24 lectures (30 minutes/lecture) more.
    [Show full text]
  • Picking up Evolution's Beat
    NEWSFOCUS PROFILE: PARDIS SABETI Florida, with a large extended family. She traces her academic success to her Picking Up Evolution’s Beat on April 24, 2008 early life in this close-knit clan. “My mother Pardis Sabeti mixes geek cool with hot science as she studies how human created a summer camp in our house, where populations have evolved to resist malaria and Lassa fever she would teach the children and make us do book reports. And my sister, who is 2 years CAMBRIDGE, MASSACHUSETTS—Over the Stevie Wonder, and Meryl Streep), and CNN older than me, would teach me and my past 72 hours, Pardis Sabeti has managed named her one of eight “geniuses who will cousin what she had learned in school.” only 2 hours of sleep each night, most of change your life.” Sabeti says mathematics was her first love. them inside a crumpled blue sleeping bag Sabeti also seems to have a genius for Her high-energy personality, she adds, she keeps under a desk at the Broad Institute raising money. While still a postdoc, her appeared in those early years. “I’m a hyper www.sciencemag.org Center for Genome Research in Cambridge, own grants totaled more than $600,000, and person,” she says. “My parents always told Massachusetts. Sabeti, who burst on the sci- she is currently a co-investigator on a me to relax.” entific scene in 2002 with a novel test for $2 million Bill and Melinda Gates Founda- Reich, who met Sabeti when they were natural selection in the human genome, has tion grant.
    [Show full text]
  • Fine Mapping of Candidate Regions Associated with Fat Deposition in Thin and Fat Tail Sheep Breeds Suggests New Insights Into Molecular Aspects of Fat Tail Selection
    Fine mapping of candidate regions associated with fat deposition in thin and fat tail sheep breeds suggests new insights into molecular aspects of fat tail selection Mohammad Hossein Moradi ( [email protected] ) Arak University Ardeshir Nejati-Javaremi University of Tehran Mohammad Moradi-Shahrbabak University of Tehran Ken G. Dodds AgResearch Rudiger Brauning AgResearch John C. McEwan AgResearch Research Article Keywords: Genomic scan, Selection signature, Lipid metabolisms, Candidate genes, Fat tail sheep Posted Date: August 23rd, 2021 DOI: https://doi.org/10.21203/rs.3.rs-832298/v1 License: This work is licensed under a Creative Commons Attribution 4.0 International License. Read Full License Page 1/26 Abstract Background Fatness related traits are economically very important in sheep production and are associated with serious diseases in humans. The fat tail is a phenotype that divides domesticated sheep into two major groups. The objective of the present study is to rene the map location of candidate regions associated with fat deposition, obtained via two separate whole genome scans contrasting thin and fat tail breeds, and to determine the nature of the selection occurring in these regions using hitchhiking approach. Results Zel (thin tail) and Lori-Bakhtiari (fat tail) breed samples that had previously been run on the Illumina Ovine 50k BeadChip, were genotyped with a denser set of SNPs in the three candidate regions using a Sequenom Mass ARRAY platform. Statistical tests were then performed using different and complementary methods based on either site frequency (FST and Median homozygosity) or haplotype (iHS and XP-EHH). Results from candidate regions on chromosome 5 and X revealed clear evidence of selection with the derived haplotypes that were consistent with selection to near xation for the haplotypes affecting fat tail size in the fat tail breed.
    [Show full text]
  • Behrooz Parhami
    Behrooz Parhami Home & Contact Behrooz Parhami's Blog & Books Page Page last updated on 2015 December 31 Curriculum Vitae Research This page was created in March 2009 as an outgrowth of the section entitled "Books Read or Heard" in my personal page. The rapid expansion of the list of Computer arithmetic books warranted devoting a separate page to it. Given that the book introductions and reviews constituted a form of personal blog, I decided to title Parallel processing this page "Blog & Books," to also allow discussion of interesting topics Fault tolerance unrelated to books from time to time. Lately, non-book items (such as political Broader research news, tech news, puzzles, oddities, trivia, humor, art, and music) have formed the vast majority of the entries. Research history List of publications Entries in each section appear in reverse chronological order. Teaching Blog entries for 2015 Archived blogs for 2014 ECE1 Freshman sem Archived blogs for 2012-13 ECE154 Comp arch Archived blogs up to 2011 ECE252B Comp arith Blog Entries for 2015 ECE252C Adv dig des 2015/12/31 (Thursday): Here are five items of potential interest. ECE254B Par proc (1) Photographer Angela Pan's fantastic capture of the Vietnam veterans' ECE257A Fault toler memorial in Washington, DC. (2) Muslim sufis play traditional Christmas music. Student supervision (3) Media circus about Bill Cosby: I am so very glad that Bill Cosby has finally Math + Fun! been charged with sexual crimes. I am not glad at all that an ugly media frenzy and trial by pundits has already begun. It was okay to discuss the issue earlier Textbooks because years of accusations by dozens of women were not being taken seriously.
    [Show full text]
  • Download Issue
    POWER AND LUXURY, IN PERFECT HARMONY THE NEW 2015 RAPIDE S The leaders you’ll Born of a unique ambition, created with the finest materials, Rapide S possesses searing sports car performance combined with sumptuous luxury. Its signature breadth of ability is need tomorrow. enhanced by the new 8-speed Touchtronic III automatic gearbox, which provides supreme refinement, enhanced acceleration and a top speed of over 200mph. Ground- Where are breaking and yet possessed of timeless beauty, Rapide S is they today? sublime, thrilling and every inch an Aston Martin. Identifying high potentials is one thing. Translating that potential into a sustainable pipeline of leadership talent is something else. From high-potential identification to leadership development and succession management, Korn Ferry can help you nurture the leaders you need to ensure continual growth. Learn more at kornferry.com/succession www.astonmartin.com Official government fuel consumption figures in mpg (litres per 100km) for the Aston Martin Rapide S: urban 13.2 (21.4); extra-urban 28.0 (10.1); combined 19.9 (14.3). CO2 emissions 332 g/km. The mpg/fuel economy figures quoted are sourced from official regulated test results obtained through laboratory testing. They are for comparability purposes only and may not reflect your real driving experience, which may vary depending on factors including road conditions, weather, vehicle load, and driving style. 55521 Korn Ferry Publication Rapide Ad - 8.25x10.5in.indd 1 16/10/2014 12:15 133042_COVER.indd 2 1/23/15 10:06 AM 1 Planning. As important to space exploration as it is for lasting success.
    [Show full text]