529 GH enhances proliferation of human hepatocytes grafted into immunodeficient mice with damaged liver Norio Masumoto1,2, Chise Tateno1,3, Asato Tachibana1,4, Rie Utoh1, Yoshio Morikawa4, Takashi Shimada4, Hiroyuki Momisako1,2, Toshiyuki Itamoto2, Toshimasa Asahara2,3 and Katsutoshi Yoshizato1,3,5 1Yoshizato Project, Cooperative Link of Unique Science and Technology for Economy Revitalization, Hiroshima Prefectural Institute of Industrial Science and Technology, 3-10-32 Kagamiyama, Higashihiroshima, Hiroshima 739-0046, Japan 2Division of Frontier Medical Science, Department of Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan 3Hiroshima University Liver Project Research Center, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan 4PhoenixBio Co. Ltd, 3-4-1 Kagamiyama, Higashihiroshima, Hiroshima 739-0046, Japan 5Developmental Biology Laboratory and Hiroshima University 21st Century COE Program for Advanced Radiation Casualty Medicine, Department of Biological Science, Graduate School of Science, Hiroshima University, 1-3-1 Kagamiyama, Higashihiroshima, Hiroshima 739-8526, Japan (Correspondence should be addressed to K Yoshizato; Email:
[email protected]) (C Tateno and K Yoshizato are now at PhoenixBio Co. Ltd, 3-4-1 Kagamiyama, Higashihiroshima, Hiroshima 739-0046, Japan) (R Utoh is now at Institute of Advanced Life and Medical Sciences, Tokyo Women’s Medical College, Kawada-chou 8-6, Shinjuku-ku, Tokyo 162-8666, Japan) Abstract We investigated effects of human (h) GH on the proliferation and cell cycle regulatory genes such as human forkhead box of h-hepatocytes that had been engrafted in the liver of M1, human cell division cycle 25A, and human cyclin D1.