Atti Dell'accademia Pontaniana Anno 2017
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Therapeutic Efficacy of Bacteriophages Ramasamy Palaniappan and Govindan Dayanithi
Chapter Therapeutic Efficacy of Bacteriophages Ramasamy Palaniappan and Govindan Dayanithi Abstract Bacteriophages are bacterial cell-borne viruses that act as natural bacteria killers and they have been identified as therapeutic antibacterial agents. Bacteriophage therapy is a bacterial disease medication that is given to humans after a diagnosis of the disease to prevent and manage a number of bacterial infections. The ability of phage to invade and destroy their target bacterial host cells determines the efficacy of bacteriophage therapy. Bacteriophage therapy, which can be specific or nonspecific and can include a single phage or a cocktail of phages, is a safe treat- ment choice for antibiotic-resistant and recurrent bacterial infections after antibi- otics have failed. A therapy is a cure for health problems, which is administered after the diagnosis of the diseases in the patient. Such non-antibiotic treatment approaches for drug-resistant bacteria are thought to be a promising new alterna- tive to antibiotic therapy and vaccination. The occurrence, biology, morphology, infectivity, lysogenic and lytic behaviours, efficacy, and mechanisms of bacterio- phages’ therapeutic potentials for control and treatment of multidrug-resistant/ sensitive bacterial infections are discussed. Isolation, long-term storage and recov- ery of lytic bacteriophages, bioassays, in vivo and in vitro experiments, and bacteri- ophage therapy validation are all identified. Holins, endolysins, ectolysins, and bacteriocins are bacteriophage antibacterial enzymes that are specific. Endolysins cause the target bacterium to lyse instantly, and hence their therapeutic potential has been explored in “Endolysin therapy.” Endolysins have a high degree of bio- chemical variability, with certain lysins having a wider bactericidal function than antibiotics, while their bactericidal activities are far narrower. -
Chronic Bacterial Prostatitis Treated with Phage Therapy After Multiple Failed Antibiotic Treatments
CASE REPORT published: 10 June 2021 doi: 10.3389/fphar.2021.692614 Case Report: Chronic Bacterial Prostatitis Treated With Phage Therapy After Multiple Failed Antibiotic Treatments Apurva Virmani Johri 1*, Pranav Johri 1, Naomi Hoyle 2, Levan Pipia 2, Lia Nadareishvili 2 and Dea Nizharadze 2 1Vitalis Phage Therapy, New Delhi, India, 2Eliava Phage Therapy Center, Tbilisi, Georgia Background: Chronic Bacterial Prostatitis (CBP) is an inflammatory condition caused by a persistent bacterial infection of the prostate gland and its surrounding areas in the male pelvic region. It is most common in men under 50 years of age. It is a long-lasting and Edited by: ’ Mayank Gangwar, debilitating condition that severely deteriorates the patient s quality of life. Anatomical Banaras Hindu University, India limitations and antimicrobial resistance limit the effectiveness of antibiotic treatment of Reviewed by: CBP. Bacteriophage therapy is proposed as a promising alternative treatment of CBP and Gianpaolo Perletti, related infections. Bacteriophage therapy is the use of lytic bacterial viruses to treat University of Insubria, Italy Sandeep Kaur, bacterial infections. Many cases of CBP are complicated by infections caused by both Mehr Chand Mahajan DAV College for nosocomial and community acquired multidrug resistant bacteria. Frequently encountered Women Chandigarh, India Tamta Tkhilaishvili, strains include Vancomycin resistant Enterococci, Extended Spectrum Beta Lactam German Heart Center Berlin, Germany resistant Escherichia coli, other gram-positive organisms such as Staphylococcus and Pooria Gill, Streptococcus, Enterobacteriaceae such as Klebsiella and Proteus, and Pseudomonas Mazandaran University of Medical Sciences, Iran aeruginosa, among others. *Correspondence: Case Presentation: We present a patient with the typical manifestations of CBP. -
BACTERIOPHAGE THERAPY Old Treatment, New Focus?
The magazine of the Society for Applied Microbiology ■ June 2009 ■ Vol 10 No 2 ISSN 1479-2699 BACTERIOPHAGE THERAPY old treatment, new focus? ■ Antimicrobial resistance in bacterial enteric pathogens ■ Mediawatch: university press office ■ Summer conference 2009 ■ Engaging the public in infectious disease ■ Charles Darwin and microbes ■ Art, cybernetics and normal flora microbiology ■ An unwanted guest for dinner ■ Careers: sales manager ■ ■ INSIDE Statnote 16: using a regression line for prediction and calibration PECS: virtual networking excellence in microbiology Cultured bacteria will not be seen dead in it. Buy your next workstation from us. Designers and manufacturers of anaerobic and microaerobic workstations since 1980 / patented dual-function portholes for user access and sample transfer / automatic atmospheric conditioning system requiring no user maintenance / available in a range of sizes and capacities to suit the needs of every laboratory / optional single plate entry system Technical sales: +44 (0)1274 595728 www.dwscientific.co.uk June 2009 ■ Vol 10 No 2 ■ ISSN 1479-2699 contentsthe magazine of the Society for Applied Microbiology members 04 Editorial: the effective communication of science 05 Contact point: full contact information for the Society 06 Benefits: what SfAM can do for you and how to join us 07 President’s and CEO’s columns 09 Membership Matters 38 Careers: sales manager 40 An unwanted guest for dinner 42 In the loop: news from PECS — virtual networking 20 43 Research Development Grant report 45 Students into Work grant reports 49 President’s Fund articles news 12 MediaWatch: the university press office 14 Med-Vet-Net: workpackage 34 28 32 publications The beauty of bacteria Charles Darwin and microbes 11 JournalWatch features information Microbiologist is published quarterly by the Society for Bacteriophage therapy: old treatment, new focus Applied Microbiology. -
Volume 5, Number 2 · Spring 2010
VOLUME 5, NUMBER 2 · SPRING 2010 DISTINCTIONS Journal of the Kingsborough Community College Honors Program Volume 5, Number 2 Spring 2010 Kingsborough Community College The City University of New York EDITOR’S COLUMN Une raison d’être his semester, I have felt energized by the buzzing student enthusiasm about social issues and the T interlocking geopolitical relationships that give such issues all their nefarious subtleties. I‘m talking here about food politics, human trafficking, the U.S. role in globalization, and a host of other challenges. I have been much impressed, particularly within the Honors program, but also in other corners of the College and University, how many student-driven initiatives are going on. This Spring-2010 issue of Distinctions reflects these collective concerns, as well as more personal attempts at exploration – some political, some not. These pieces explore various aspects of our present condition through multiple means, from Micaela Santana‘s photographic meditation on air travel to Dorothy Franco‘s discussion of operatic technique, from Cheryl Bond‘s queries about Afghan art history to Julianne Miller‘s interrogation of Fannie Mae. (I know, we need to get more men to do such good work!) In reading these essays, as well as the other 40 or so submissions, I remember that being able to write such pieces requires both a commitment to taking the time to read, observe, and reflect, as well as the luxury of doing so. And I use the term ―luxury‖ because, for many students at Kingsborough, such intellectual work is not necessarily a given. I routinely hear stories of domestic violence, economic hardship, medical problems, and emotional trauma from my students. -
University Microfilms International 300 North Zeeb Road Ann Arbor, Michigan 48106 USA St
INFORMATION TO USERS This material was produced from a microfilm copy of the original document. While the most advanced technological means to photograph and reproduce this document have been used, the quality is heavily dependent upon the quality of the original subm itted. The following explanation of techniques is provided to help you understand markings or patterns which may appear on this reproduction. 1. The sign or "target" for pages apparently lacking from the document photographed is "Missing Page(s)". If it was possible to obtain the missing page(s) or section, they are spliced into the film along w ith adjacent pages. This may have necessitated cutting thru an image and duplicating adjacent pages to insure you complete continuity. 2. When an image on the film is obliterated with a large round black mark, it is an indication that the photographer suspected that the copy may have moved during exposure and thus cause a blurred image. Youa w ill find good image o f the page in the adjacent frame. 3. When a map, drawing or chart, etc., was part of the material being photographed the photographer followed a definite method in "sectioning" the material. It is customary to begin photoing at the upper left hand corner of a large sheet and to continue photoing from left to right in equal sections with a small overlap. If necessary, sectioning is continued again — beginning below the first row and continuing on until com plete. 4. The majority of users indicate that the textual content is of greatest value, however, a somewhat higher quality reproduction could be made from "photographs" if essential to the understanding of the dissertation. -
Bacteriophages As Potential Tools for Use in Antimicrobial Therapy and Vaccine Development
pharmaceuticals Review Bacteriophages as Potential Tools for Use in Antimicrobial Therapy and Vaccine Development Beata Zalewska-Pi ˛atek 1,* and Rafał Pi ˛atek 1,2 1 Department of Molecular Biotechnology and Microbiology, Chemical Faculty, Gda´nskUniversity of Technology, Narutowicza 11/12, 80-233 Gda´nsk,Poland; [email protected] 2 BioTechMed Center, Gda´nskUniversity of Technology, Narutowicza 11/12, 80-233 Gda´nsk,Poland * Correspondence: [email protected]; Tel.: +58-347-1862; Fax: +58-347-1822 Abstract: The constantly growing number of people suffering from bacterial, viral, or fungal infec- tions, parasitic diseases, and cancers prompts the search for innovative methods of disease prevention and treatment, especially based on vaccines and targeted therapy. An additional problem is the global threat to humanity resulting from the increasing resistance of bacteria to commonly used antibiotics. Conventional vaccines based on bacteria or viruses are common and are generally effective in pre- venting and controlling various infectious diseases in humans. However, there are problems with the stability of these vaccines, their transport, targeted delivery, safe use, and side effects. In this context, experimental phage therapy based on viruses replicating in bacterial cells currently offers a chance for a breakthrough in the treatment of bacterial infections. Phages are not infectious and pathogenic to eukaryotic cells and do not cause diseases in human body. Furthermore, bacterial viruses are sufficient immuno-stimulators with potential adjuvant abilities, easy to transport, and store. They can also be produced on a large scale with cost reduction. In recent years, they have also provided an ideal platform for the design and production of phage-based vaccines to induce protective host immune responses. -
BACTERIOPHAGES Clinical Applications
BACTERIOPHAGES Clinical Applications X. Wittebole, MD Critical Care Department BACTERIOPHAGES The most abundant and ubiquitous organism on Earth 104 – 108 / ml particles in aquatic systems 109 / g particles in soil 1032 particles on Earth > 6300 different bacteriophages discovered and described 6196 bacterial viruses, 88 aracheal viruses Small viruses able at killing bacteria while they do not affect other cell lines 2 Cliniques universitaires Saint-Luc – Nom de l’orateur 1917 : FELIX D’HERELLE Paris vs Quebec ? (1875 – 1949) Lived in Paris, Lille, Leiden, Montreal Never graduated in Medicine Worked as a microbiologist in Guatemala Travelled around the world Found that locust were killed by Coccobacillus acridorium Found « plaques » in culture of dysentery bacilli Cliniques universitaires Saint-Luc – Nom de l’orateur Cliniques universitaires Saint-Luc – Nom de l’orateurD’Herelle F. C R Acad Sci Paris. 1917 D’Herelle F. C R Acad Sci Paris. 1917 Cliniques universitaires Saint-Luc – Nom de l’orateur D’Herelle F. Bull N Y Acad Med.1931 Cliniques universitaires Saint-Luc – Nom de l’orateur 1921 First report on the use of bacteriophage in human 6 patients Anthrax and furoncles Subcutaneous injections of Staphylococcus bacteriophages Various doses Complete recovery of those lesions within 24-48 hours Side effect: fever (for some patients) and local pain Bruynoghe R, Maisin J. C Soc Biol.1921 Cliniques universitaires Saint-Luc – Nom de l’orateur Bruynoghe R, Maisin J. C Soc Biol.1921 Cliniques universitaires Saint-Luc – Nom de l’orateur PHAGOTHERAPY -
Manoscritti 1-2800
Manoscritti 1-2800 Colloc Cons Autore/mi Gio azion Anno Mese Luogo Destinatario Titolo/argomento trattato isten Note ttente rno e za Montolivet - Propone la scoperta di un rimedio per una Ministro malattia che colpisce le pecore dell'Appennino Della Casa, dell'Interno a ligure e che i pastori chiamano “Drubegu” 2 c.; 1 - I Bartolomeo 1812 Settembre 16 S.L. Parigi [Idrope pettorale] copia Risponde a una richiesta di un parere su una Della Casa, scoperta del signor Ducoredic relativa all’arnia 4 c. - 1 - II Bartolomeo 1813 settembre 8 Celle «Colleghi» piramidale copia Balbo Prospero Comunica la scoperta di un rimedio per una - Presidente malattia delle pecore infette da idrope Della Casa, dell’Accademia pettorale, ossia “Lacchegia acquosa” più nota 1 - III Bartolomeo 1833 febbraio 13 Genova delle Scienze sotto il nome di “Durbiga” 2 c. Chabrol - Prefetto del dipartiment Risponde a una richiesta d’introduzione della o di Della Casa, coltura nella Liguria meridionale di una nuova 2 c. - 1 - IV Montenotte 1807 novembre 18 Savona Bartolomeo pianta scoperta dal Della Casa copia Montolivet - Annuncia al Della Casa una visita dell’Ispettore Ministro Lullin de Chateauvieux che dovrebbe fornire un dell’Interno Della Casa, parere sul rimedio per la “Durbega” delle 2 c. - 1 - V a Parigi 1812 ottobre 26 Parigi Bartolomeo pecore scoperta dal Della Casa copia “Presidente 3 c. Casoni, dell’Accademia Integra la descrizione della scoperta del + un C[arlo] - delle Scienze sistema per ottenere la forza motrice per la diseg 2 - I Avvocato 1864 Maggio 15 Torino di Torino” direzione dei globi aerostatici no Pagina 1 Manoscritti 1-2800 Colloc Cons Autore/mi Gio azion Anno Mese Luogo Destinatario Titolo/argomento trattato isten Note ttente rno e za Presidente Casoni, dell’Accademia Presenta un sistema meccanico onde ottenere Carlo - delle Scienze la forza motrice per la direzione dei globi 2 - II Avvocato 1864 maggio 14 Torino di Torino aerostatici 2 c. -
Bruno Miguel Barbosa Da Costa Terapia Fágica
Universidade de Aveiro Departamento de Biologia 2010 Bruno Miguel Terapia Fágica: Perspectivas na Aplicação Clínica Barbosa da Costa Universidade de Aveiro Departamento de Biologia 2010 Bruno Miguel Terapia Fágica: Perspectivas na Aplicação Clínica Barbosa da Costa Dissertação apresentada à Universidade de Aveiro para cumprimento dos requisitos necessários à obtenção do grau de Mestre em Microbiologia, realizada sob orientação científica da Professora Doutora Maria Adelaide de Pinho Almeida, Professora Auxiliar do Departamento de Biologia da Universidade de Aveiro. II “ A história da doença é em última análise a história da luta entre as bactérias e os bacteriófagos” d´Herelle III O júri Presidente Prof. Doutora Maria Ângela Sousa Dias Alves Cunha Professora Auxiliar do Departamento de Biologia da Universidade de Aveiro Vogais Doutor Artur Jorge da Costa Peixoto Alves (arguente) Investigador Auxiliar do Centro de Estudos do Ambiente do Mar (CESAM) Universidade de Aveiro Prof. Doutora Maria Adelaide de Pinho Almeida (orientadora) Professora Auxiliar do Departamento de Biologia da Universidade de Aveiro IV Agradecimentos Os meus agradecimentos vão para todos aqueles que sempre me apoiaram e que de certo modo contribuíram para a minha formação pessoal e profissional. Deste modo não poderei deixar de agradecer: Ao Professor Doutor António Carlos Matias Correia, coordenador do Mestrado de Microbiologia da Universidade de Aveiro, pela disponibilidade prestada para encontrar um tema e um orientador para a minha dissertação; À Doutora Maria Adelaide de Pinho Almeida, orientadora científica desta dissertação, do Departamento de Biologia da Universidade de Aveiro, pelo acolhimento, acompanhamento e pela orientação, disponibilidade e formação; A todas as pessoas que sempre acreditaram em mim e que sempre estiveram presentes nos momentos mais importantes da minha vida. -
The Phage S Are Back
ISSN 2364-2351 | A 6 0 711 | Interview Aleks Engel from Novo Holdings on a new fund Life Sciences and that will mobilise Industry Magazine SMEs in the fight against antibiotic Spring Edition 2018 | Volume 17 | 20 € resistance Antibiotic Resistance FREE EXCERPT The phage s are back Genome editing Immunology Big Bioindustry GMP bioproduction EU Court’s Advocate General How fast food corrupts your Attracting investment to scale Which CDMOs will seize the disappoints GM opponents immune system permanently up bio-based production lead in an expanding market? CONFERENCE LOCATION AT THE INNOVATION UND START-UP CENTER FOR BIOTECHNOLOGY J Conference Rooms (up to 100 persons) J IZB Residence CAMPUS AT HOME for guests of the Campus Martinsried/ Grosshadern and conference guests only J Restaurant SEVEN AND MORE Fördergesellschaft IZB mbH J Catering & Restaurant Freshmaker Am Klopferspitz 19 82152 Planegg/Martinsried Tel.: + 49 (0)89.55 279 48-27 Fax: + 49 (0)89.55 279 48-29 E-Mail: [email protected] www.izb-online.de European Biotechnology | Spring Edition | Vol. 17 | 2018 INTRO 3 FREE EXCERPT We need creative investment to tackle AMR Each year, 700,000 people worldwide die of resistant infections; estimates say this figure will rise to 10 million victims a year by 2050 unless effective action is taken to tackle antimicrobial resist- ance (AMR).1 From an investment perspective, the main problem is a lack of incentives for the private sector to engage in AMR- related R&D. The need to use antimicrobials rationally to avoid the development of resistance seriously limits a developer’s expected return on investment (ROI). -
The Role of the New Zealand Reference Culture Collection, Medical Section, in Supporting Microbiological Quality Control, Teachi
EX -SOVIET DEVELOPMENTS IN THE ELIAVA INSTITUTE OF BACTERIOPHAGE, MICROBIOLOGY AND VIROLOGY A WORLD PREMIER INSTITUTE IN BACTERIOPHAGE RESEARCH by Dr. Nina Chanishvili The Eliava Institute of Bacteriophage, Microbiology and Virology, 3, Gotua street, 0160, Tbilisi, Georgia Tel: +995 32 38 27 62, Fax +995 32 22 19 65 [email protected] Introduction At the beginning of the 20th century d’Herelle suggested that bacterial viruses (bacteriophgaes) might be applied to the control of bacterial diseases. In the West this idea was explored in a desultory fashion only and was eventually discarded largely due to the advent of extensive antibiotic usage. However, interest was maintained in the countries of the FSU where bacteriophage therapy has been applied extensively since that time. Central to this work was the Eliava Institute of Bacteriophage, Microbiology and Virology in Tbilisi, Georgia, which was founded thanks to joint efforts of two professors George Eliava and Felix D’Herelle (Fig. 1). This institute remained continuously active in this field for more than 75 years. Figure 1. Dr. Elena Makashvili (left), Professor Felix D’Herelle (in the centre), Professor George Eliava (right). Photo is taken in 1934 in Tbilisi, Georgia. Vast collections of prophylactic and therapeutic phages have been gathered during the long history of the institute. In the Eliava IBMV, phages were sought for bacterial pathogens implicated in disease outbreaks in different parts of the SU and were dispatched for use in hospitals throughout the country. Although infections caused by a wide variety of bacterial pathogens have been treated, much of this has been published in Russian and is not readily available in the West. -
Tagliolo Monferrato
atti del convegno stUdi di storiA ovAdese promossi in occasione del 45° vAdese di fondazione dell’accademia Urbense o e dedicati alla memoria di Adriano bausola Ovada, 7-8 dicembre 2002 toriA s a cura di alessandrO lagUzzi e ediliO riccardini tUdi di s rbense U ccAdemiA A Ovada MeMOrie dell’accadeMia Urbense n. 53 - 2005 MeMorIe dell’ACCAdeMIA UrBeNSe Collana a cura di Alessandro Laguzzi Nuova Serie n. 53 In copertina ritratto di Ignazio Benedetto Buffa, copia di Maria Adele Gonzales (Magovi) dall’originale di Casa Buffa. ACCAdeMIA UrBeNSe - ovAdA Atti del Convegno Studi di Storia ovadeSe promossi in occasione del 45° di fondazione dell’Accademia Urbense e dedicati alla memoria di adriano Bausola ovada, 7-8 dicembre 2002 a cura di AleSSANdro lAGUzzI e edIlIo rICCArdINI ovada - 2005 CoMItAto d’oNore Fabrizio Palenzona, Presidente Amm. Provinciale vincenzo robbiano, Sindaco di ovada on. lino rava, deputato al Parlamento nazionale daniele Borioli, vice Presidente Amm. Provinciale Adriano Icardi, Assessore Provinciale alla Cultura Franco Caneva, Assessore Provinciale Gianfranco Comaschi, Assessore Provinciale dino Angelini, Sindaco di Mornese Giuseppe Coco, Sindaco di Silvano d’orba luciana repetto, vice Sindaco di ovada CoMItAto SCIeNtIFICo Geo Pistarino romeo Pavoni emilio Costa CoMItAto orGANIzzAtore: Alessandro laguzzi Giorgio oddini Giacomo Gastaldo Paolo Bavazzano edilio riccardini Impaginazione: Simona vaga - Fotolito drP - Alessandria redazione, Paolo Bavazzano, Giacomo Gastaldo, Piero Bersi. ISSN 1723-4824 Indice daniele BorIolI, vice Presidente Ammin. Provinciale Introduzione p. 11 Andrea luigi oddoNe, Sindaco di ovada Saluto p. 13 Alessandro lAGUzzI Premessa p. 15 Anna Maria BAUSolA GrIllo Adriano Bausola nei ricordi della sorella p. 21 Geo PIStArINo Prefazione p.