Bone Homeostasis As a Multifaceted Puzzle: from WNT Ligands to Metal-Ion Transporters
Faculteit Farmaceutische, Biomedische en Diergeneeskundige Wetenschappen Bone Homeostasis as a Multifaceted Puzzle: From WNT Ligands to Metal-ion Transporters Bothomeostase als een Veelzijdige Puzzel: Van WNT Liganden tot Metaal-ion Transporters Proefschrift voorgelegd tot het behalen van de graad van Doctor in de Biomedische Wetenschappen aan de Universiteit Antwerpen te verdedigen door Gretl HENDRICKX Bone Homeostasis as a Multifaceted Puzzle: From WNT Ligands to Metal-ion Transporters Doctoral dissertation, University of Antwerp, Belgium ISBN: 978-94-6299-582-6 Author: G. Hendrickx Cover Design: Lien Campo, concept by G. Hendrickx Printing: Ridderprint BV © Copyright G. Hendrickx, Antwerpen 2017 All rights reserved. No parts of this book may be reproduced, stored in a retrieval system or transmitted in any form or by any means without prior permission of the holder of the copyright. Curiosity-Driven MEMBERS OF THE JURY Prof. Dr. Wim Van Hul, promotor Center of Medical Genetics, University of Antwerp and University Hospital of Antwerp, Belgium Dr. Eveline Boudin, co-promotor Center of Medical Genetics, University of Antwerp and University Hospital of Antwerp, Belgium Prof. Dr. Vincent Timmerman, chairman VIB Department of Molecular Genetics, University of Antwerp, Belgium Prof. Dr. Marc Cruts VIB Department of Molecular Genetics, University of Antwerp, Belgium Prof. Dr. Bart Loeys Center of Medical Genetics, University of Antwerp and University Hospital of Antwerp, Belgium Prof. Dr. Geert Carmeliet Department of Cellular and Molecular Medicine, KU Leuven, Belgium Prof. Dr. Martine Cohen-Solal Department of Rheumatology, University Paris-Diderot, France TABLE OF CONTENTS Table of Contents I. Summary/Samenvatting 9 II. Introduction 15 Chapter 1 17 A Look Behind The Scenes: The Risk and Pathogenesis of Primary Osteoporosis Gretl Hendrickx, Eveline Boudin and Wim Van Hul Nature Reviews Rheumatology 2015; 11;462–474 Chapter 2 51 An Introduction to WNT Signaling III.
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