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AFAR Grant Recipients — 1981-2005 Letter from the Executive Director ...... 1 Major Supporters of the 2005 Grant Programs Celebrating 2005 Selection Committees ...... 2 The AFAR Board of Directors AFAR Research Grant ...... 6 A Quarter Century Anonymous Donor AFAR Affiliate Research Grant ...... 16 The Atlantic Philanthropies of Research AFAR/Glenn Breakthroughs in Gerontology (BIG) Award ....16 The Bedminster Fund Cardinal Health Foundation AFAR/Pfizer Innovations in Aging Research Award ...... 16 The Clarence and Anne Dillon Dunwalke Trust AFAR/Pfizer Research Grant ...... 17 The Cleveland Foundation Paul Beeson Career Development Award Community Health Foundation of Western & Central New York in Aging Research ...... 17 Eisai Inc AFAR/Merck Junior Investigator Award in Geriatric Clinical Pharmacology...... 20 The Ellison Medical Foundation Lillian R. Gleitsman Foundation The American Federation for Aging Research (AFAR) is a nonprofit organization AFAR/Ellison Medical Foundation Senior Postdoctoral Fellows ...... 20 The Glenn Foundation for Medical Research whose mission is to support biomedical research on aging. We fulfill this mission by: AFAR/Glenn Research Grant for Postdoctoral Fellows ...... 21 The Partners of Goldman Sachs & Company The John A. Hartford Foundation AFAR/Merck Research Scholarship in Geriatric ® Supporting biomedical research that furthers our understanding of the Pharmacology for Medical and Pharmacy Students ...... 21 William Randolph Hearst Foundation aging process and its associated diseases and disorders; Diana J. and C. A. Kalman ® Offering opportunities for scientists and physicians to exchange new ideas AFAR/Glenn Scholarship for Research and knowledge about aging; in the Biology of Aging ...... 22 F. M. Kirby Foundation, Inc. ® Building a cadre of early career scientists in aging research and in the AFAR/The John A. Hartford Foundation Academic Fellowship Merck Company Foundation practice of geriatric medicine; and Program in Geriatric Medicine and Geriatric Psychiatry ....27 National Institute on Aging ® Promoting awareness among the general public about the importance of aging research. Medical Student Summer Research The New York Community Trust Training in Aging Program ...... 29 Diane Nixon Since 1981, AFAR has awarded nearly $87 million to more than 2,100 early to AFAR-Ohio Medical Student Summer Research Training in Pfizer Inc mid-career investigators and students, with the goal of encouraging more of Aging Program ...... 37 The Richard and Hinda Rosenthal Foundation the nation’s scientists and physicians to enter and stay in the fields of AFAR/ISOA Program for Drug Discovery in Cognitive Decline gerontology and geriatric medicine. These scientists are conducting cutting- and Alzheimer’s Disease ...... 38 Joseph L. K. Snyder Trust edge research on aging and age-related diseases, such as Alzheimer’s, cancer, The Starr Foundation osteoporosis, diabetes and heart disease. Support for AFAR grants comes from AFAR/The Foundation for Fighting Blindness Joint Program for Career Development Awards in Support of Research on The Irving S. Wright Endowment the generous contributions of corporations, foundations and individuals. Age-Related Macular Degeneration ...... 38 For more information about AFAR, please visit our organizational website, www.afar.org. For more information about aging research and staying healthy AFAR/Hartford Gero-Physician-Scientist as you age, please visit our consumer websites, www.Infoaging.org and Training Program ...... 38 www.HealthCompass.org. AFAR Milestones...... 39 Letter from the Executive Director 25th Anniversary Grantee Directory

he American Federation for Aging Research (AFAR) is pleased to present its 25th anniversary grantee directory, highlighting all of the recipients of AFAR research grants and AFAR-administered grants programs to date.

TWe are proud to have supported more than 2,100 early-career investigators and medical students — the best and the brightest scientific minds in the nation — with funding of nearly $87 million. These grant recipients have made major inroads in our understanding of how and why we age, leading to important discoveries about how age-related diseases and disorders can be prevented or stalled.

From telomeres to stem cell research to the search for longevity genes, during the last 25 years, research on aging has yielded substantial breakthroughs, helping to identify the rates of aging in species and the susceptibility of disease, improving healthspan as well as lifespan.

We thank our esteemed review committee members and the many supporters who have made what we do possible. A full listing of review committee members and supporters is contained in this directory.

A special acknowledgment and dedication of this publication goes to our dedicated board member Dorothy Dillon Eweson, who died in June 2005. Dorothy was an early advocate for research in aging, supporting AFAR programs that have enabled scientists to pursue and sustain careers in the field, including an endowed lecture series that allows AFAR researchers to present their findings at annual scientific or medical specialty association meetings. We are grateful for her longstanding commitment and generosity.

At a time of limited funding for research on aging coupled with a burgeoning aging population, AFAR’s support is as critical as ever. As we celebrate 25 years of supporting great minds in science, we renew our commitment to helping even more scientists gain a foothold in the area of aging research.

Stephanie Lederman

1 LINDA P. FRIED, M.D., M.P.H. NATIONAL SCIENTIFIC 2005 AFAR Selection Committees Johns Hopkins University Medical Institutions Baltimore, Maryland ADVISORY COUNCIL WILLIAM R. HAZZARD, M.D. (NSAC) AFAR’s committees are comprised of experts in aging research and related University of Washington School of Medicine areas of research who volunteer their time and expertise to the AFAR Seattle, Washington review processes. Their dedication, enthusiasm and commitment is crucial Reviews grant proposals for the to the success of AFAR’s grant programs. EDWARD KOO, M.D. AFAR Research Grant, the University of California, San Diego Pfizer/AFAR Innovations in Aging La Jolla, California Grant, and the Ellison Medical Foundation/AFAR Senior LEWIS LIPSITZ, M.D. JAMES NELSON, Ph.D. Postdoctoral Research Program AFAR Research University of Texas Health Science Center Harvard Medical School Committee San Antonio, Texas Boston, Massachusetts CARMELA R. ABRAHAM, Ph.D. LINA OBEID, M.D. LAWRENCE RAISZ, M.D. Boston University School of Medicine Reviews grant proposals for the University of Connecticut Health Center Medical University of South Carolina Boston, Massachusetts AFAR Research Grant, the Farmington, Connecticut Charleston, South Carolina Pfizer/AFAR Innovations in Aging ITAMAR ABRASS, M.D. ALAN R. SHULDINER, M.D. Grant, and the Ellison Medical JOHN SEDIVY, Ph.D. University of Washington Brown University University of Maryland School of Medicine Foundation/AFAR Senior Seattle, Washington Providence, Rhode Island Baltimore, Maryland Postdoctoral Research Program AYOTUNDE ADEAGBO, Ph.D. RICHARD A. MILLER, M.D., Ph.D., Chair University of Louisville University of Michigan Glenn/AFAR Merck/AFAR Junior Louisville, Kentucky Ann Arbor, Michigan Breakthroughs in Investigators in NEIL ALEXANDER, M.D. JUDD AIKEN, Ph.D. University of Michigan University of Wisconsin College of Agriculture Gerontology (BIG) Geriatric Clinical Ann Arbor, Michigan and Life Sciences Madison, Wisconsin Selection Committee Pharmacology KATRIN ANDREASSON, M.D. Johns Hopkins University School of Medicine RICHARD A. MILLER, M.D., Ph.D., Chair MARK BEERS, M.D., Chair ADAM ANTEBI, Ph.D. Baltimore, Maryland University of Michigan Merck & Company, Inc. Baylor College of Medicine Ann Arbor, Michigan West Point, Pennsylvania Houston, Texas ROBERT ARKING, Ph.D. Wayne State University EDWARD KOO, M.D. MEGHAN GERETY, M.D. ANDRZEJ BARTKE, Ph.D. Detroit, Michigan University of California, San Diego University of Texas Health Science Center Southern Illinois University La Jolla, California San Antonio, Texas Springfield, Illinois NANCY L. BAENZIGER, Ph.D. Washington University GEORGE M. MARTIN, M.D. BRUCE POLLOCK, M.D., Ph.D. LAURA DUGAN, M.D. St. Louis, Missouri University of Washington University of Pittsburgh University of California, San Diego Seattle, Washington Pittsburgh, Pennsylvania San Diego, California BEN A. BAHR, Ph.D. University of Connecticut DAVID G. NICHOLLS, Ph.D. JAY M. EDELBERG, M.D., Ph.D. Storrs, Connecticut Buck Institute for Age Research Weill Medical College of Cornell University The Medical Student Novato, California New York, New York NIR BARZILAI, M.D. Summer Training in Albert Einstein College of Medicine JOHN SEDIVY, Ph.D. DAVID FINK, M.D. Bronx, New York Brown University University of Michigan School of Medicine Aging Program Providence, Rhode Island Ann Arbor, Michigan JOHN BAUM, M.D. PATRICIA BARRY, M.D., M.P.H., Chair University of Rochester MARC TATAR, Ph.D. SUZANNE GUENETTE, Ph.D. Merck Institute of Aging and Health Rochester, New York Brown University Massachusetts General Institute for Washington, D.C. Providence, Rhode Island Neurodegenerative Disease GAL BITAN, Ph.D. Harvard Medical School RONALD D. ADELMAN, M.D. David Geffen School of Medicine at UCLA Boston, Massachusetts Weill Medical College of Cornell University Los Angeles, California Program Advisory New York, New York PATRICK R. HOF, M.D. ROBERT BLANK, M.D., Ph.D. Mount Sinai School of Medicine Committee for the THOMAS A. CAVALIERI, D.O. University of Wisconsin Medical School New York, New York UMDNJ-School of Osteopathic Medicine Madison, Wisconsin Beeson Career Stratford, New Jersey PETER HORNSBY, Ph.D. VILHELM A. BOHR, M.D., Ph.D. University of Texas Health Science Center at Development Award JAMES L. RUDOLPH, M.D. National Institute on Aging San Antonio Harvard Medical School National Institutes of Health San Antonio, Texas MARY TINETTI, M.D., Chair Boston, Massachusetts Baltimore, Maryland Yale University School of Medicine ROGER McCARTER, Ph.D. New Haven, Connecticut CRYSTAL SIMPSON, M.D., M.H.S. ROBERT A. BONOMO, M.D. Pennsylvania State University Johns Hopkins University Louise Stokes Cleveland VAMC State College, Pennsylvania DAN BLAZER, M.D., Ph.D. Baltimore, Maryland Cleveland, Ohio Duke University Medical Center DAVID G. MORGAN, Ph.D. Durham, North Carolina ANITA WOODS, Ph.D. ADELE BOSKEY, Ph.D. Baylor College of Medicine 2 University of South Florida Hospital for Special Surgery Tampa, Florida HARVEY J. COHEN, M.D. Houston, Texas New York, New York Duke University Medical Center Durham, North Carolina JOSEPH BRESSLER, Ph.D. MARK D’ESPOSITO, M.D. JEROME FLEG, M.D. SUZANNE GUENETTE, Ph.D. Johns Hopkins University School of Public University of California, Berkeley National Heart, Lung, and Blood Institute Massachusetts General Hospital/Harvard Health Berkeley, California National Institutes of Health Medical School Baltimore, Maryland Bethesda, Maryland Charlestown, Massachusetts WILLIAM DALE, M.D., Ph.D. JACOB A. BRODY, M.D. University of Chicago ROBERT FLOYD, Ph.D. THEODORE J. HAHN, M.D. University of Illinois at Chicago Chicago, Illinois University of Oklahoma Health Science Center VA West Los Angeles Healthcare Center Chicago, Illinois Oklahoma City, Oklahoma University of California, Los Angeles KELVIN DAVIES, Ph.D. Los Angeles, California SUSAN BROOKS, Ph.D. University of Southern California MARY KAY FRANCIS, Ph.D. University of Michigan Los Angeles, California Villanova University ROGER HAJJAR, M.D. Ann Arbor, Michigan Villanova, Pennsylvania Massachusetts General Hospital/Harvard LUISA DiPIETRO, D.D.S., Ph.D. Medical School HOLLY M. BROWN-BORG, Ph.D. Loyola University ROBERT R. FREEDMAN, Ph.D. Charlestown, Massachusetts University of North Dakota School of Medicine Maywood, Illinois Wayne State University School of Medicine Grand Forks, North Dakota Detroit, Michigan COURTNEY D. HALL, Ph.D., P.T. LINDA A. DOKAS, Ph.D. Emory University/Atlanta VAMC JOHN N. BUCHHOLZ, Ph.D. Medical College of Ohio SALLY FRENKEL, Ph.D. Atlanta, Georgia Loma Linda University School of Medicine Toledo, Ohio New York University Hospital for Joint Diseases Loma Linda, California New York, New York JEFFREY M. HAUSDORFF, Ph.D. EVAN DREYER, M.D., Ph.D. Tel-Aviv Sourasky Medical Center JOCHEN BUCK, M.D., Ph.D. Glaucoma Cataract Consultants MATTHEW P. FROSCH, M.D. Ph.D. Tel Aviv, Israel Weill Medical College of Cornell University Pittsburgh, Pennsylvania Massachusetts General Hospital New York, New York Harvard Medical School LAURA HAYNES, Ph.D. MONICA DRISCOLL, Ph.D. Charlestown, Massachusetts Trudeau Institute JAMES BURKE, M.D., Ph.D. Rutgers University Saranac Lake, New York Duke University Medical Center Piscataway, New Jersey LORISE C. GAHRING, Ph.D. Durham, North Carolina University of Utah School of Medicine STEPHEN L. HELFAND, M.D. GUSTAVO DUQUE, M.D. Salt Lake City, Utah University of Connecticut Health Center KATHERINE G. BUTLER, Ph.D. McGill University Health Centre Farmington, Connecticut San Jose State University Montreal, Canada DOUGLAS R. GALASKO, M.D. Monterey, California VA Medical Center BOB HELFERT, Ph.D. CATHERINE DUBEAU, M.D. University of California, San Diego Southern Illinois University School of Medicine JAMES CAREY, Ph.D. University of Chicago San Diego, California Springfield, Illinois University of California, Davis Chicago, Illinois Davis, California JAMES W. GAUBATZ, Ph.D. JANET HENDERSON, Ph.D. KAREN DUFF, Ph.D. University of South Alabama Centre for Bone & Periodontal Research CATHY CARLSON, D.V.M., Ph.D. Nathan Kline Institute/New York University Mobile, Alabama Montreal, Quebec University of Minnesota Orangeburg, New York St. Paul, Minnesota DEBRA GEARHART, Ph.D. BRIAN HERMAN, Ph.D. GUSTAVO DUQUE, M.D., Ph.D. University of Georgia College of Pharmacy University of Texas Health Science Center MONICA J. CARSON, Ph.D. McGill University Health Centre Augusta, Georgia San Antonio, Texas University of California, Riverside Montreal, Canada Riverside, California GODFREY S. GETZ, M.D., Ph.D. AHMAD HEYDARI, Ph.D. STEVE ESTUS, Ph.D. The University of Chicago Wayne State University MARY LOU CASPERS, Ph.D. University of Kentucky Medical Center Chicago, Illinois Detroit, Michigan University of Detroit Mercy Lexington, Kentucky Detroit, Michigan THOMAS M. GILL, M.D. FUKI HISAMA, M.D. JIM R. FADEL, Ph.D. Yale University School of Medicine Yale University School of Medicine PRISCILLA CLARKSON, Ph.D. University of South Carolina School of New Haven, Connecticut New Haven, Connecticut University of Massachusetts Medicine Amherst, Massachusetts Columbia, South Carolina TODD GOLDE, M.D., Ph.D. PATRICK R. HOF, M.D. Mayo Medical School Mount Sinai School of Medicine DENNIS O. CLEGG, Ph.D. JEFF C. FALCONE, Ph.D. Jacksonville, Florida New York, New York University of California, Santa Barbara University of Louisville Health Science Center Santa Barbara, California Louisville, Kentucky JAMES S. GOODWIN, M.D. SHAWN HOLT, Ph.D. The University of Texas Medical Branch Medical College of Virginia at VCU HARVEY JAY COHEN, M.D. MEL B. FEANY, M.D., Ph.D. Galveston, Texas Richmond, Virginia Duke University Medical Center Brigham and Women’s Hospital/Harvard Durham, North Carolina University ANDREA C. GORE, Ph.D. ERIC W. HOWARD, Ph.D. Boston, Massachusetts The University of Texas at Austin University of Oklahoma Health Science Center KEVIN CONLEY, Ph.D. Austin, Texas Oklahoma City, Oklahoma University of Washington Medical Center DEBORAH A. FERRINGTON, Ph.D. Seattle, Washington University of Minnesota LUC E. GOSSELIN, Ph.D. KAREN HUBBARD, Ph.D. Minneapolis, Minnesota University at Buffalo - SUNY The City College of New York VINCENT L. CRYNS, M.D. Buffalo, New York New York, New York Northwestern University School of Medicine ROGER FIELDING, Ph.D. Chicago, Illinois Tufts University GUNNAR K. GOURAS, M.D. MICHAEL L. HUTTON, Ph.D. Boston, Massachusetts Weill Medical College of Cornell University Mayo Medical School ANA MARIA CUERVO, M.D., Ph.D. New York, New York Jacksonville, Florida Albert Einstein College of Medicine TRACY L. FITZGERALD, Ph.D. Bronx, New York University of Maryland, College Park LOTTA GRANHOLM-BENTLEY, Ph.D., D.D.S. DONALD K. INGRAM, Ph.D. College Park, Maryland Medical University of South Carolina National Institute on Aging CHRISTINE CURCIO, Ph.D. Charleston, South Carolina National Institutes of Health University of Alabama School of Medicine Baltimore, Maryland 3 Birmingham, Alabama BRAD JOHNSON, M.D., Ph.D. PHONG T. LE, Ph.D. ROBERT D. MOIR, Ph.D. DANIEL PROMISLOW, Ph.D. University of Pennsylvania Loyola University Medical Center Massachusetts General Hospital/Harvard University of Georgia Philadelphia, Pennsylvania Maywood, Illinois Medical School Athens, Georgia Charlestown, Massachusetts THOMAS E. JOHNSON, Ph.D. WILLIAM LEE, Ph.D. LeBRIS QUINN, Ph.D. University of Colorado The David Axelrod Institute SHIN MURAKAMI, Ph.D. VA Puget Sound Health Care System Boulder, Colorado Albany, New York University of Louisville Medical School Tacoma, Washington Louisville, Kentucky THOMAS JONES, M.D., M.P.H. ALLAN I. LEVEY, M.D., Ph.D. JACOB RABER, Ph.D. Merck & Co., Inc. Emory University MOHAN NATARAJAN, Ph.D. Oregon Health & Science University West Point, Pennsylvania Atlanta, Georgia University of Texas Health Science Center Portland, Oregon San Antonio, Texas EVAN KELLER, D.V.M., Ph.D. RICHARD Z. LIN, M.D. JOE RAMSDELL, M.D. University of Michigan State University of New York, Stony Brook BIJAYA NAYAK, Ph.D. University of California, San Diego Ann Arbor, Michigan Stony Brook, New York University of Texas Health Science Center San Diego, California San Antonio, Texas JEFF KELLER, Ph.D. ROBERT D. LINDEMAN, M.D. THOMAS RANDO, M.D., Ph.D. University of Kentucky, Lexington The University of New Mexico DAVID G. NICHOLLS, Ph.D. Stanford University/VAPACS Lexington, Kentucky Albuquerque, New Mexico Buck Institute for Age Research Palo Alto, California Novato, California ANNE KENNY, M.D. GORDON LITHGOW, Ph.D. MAHENDRA RAO, M.D., Ph.D. University of Connecticut Health Center The Buck Institute for Age Research LAURA NIKLASON, M.D., Ph.D. National Institute on Aging Farmington, Connecticut Novato, California Duke University National Institutes of Health Durham, North Carolina Baltimore, Maryland STUART KIM, Ph.D. GUOSONG LIU, M.D., Ph.D. Stanford University MIT/Picower Center for Learning & Memory MARIANA NIKOLOVA-KARAKASHIAN, Ph.D. JANE RECKELHOFF, Ph.D. Stanford, California Cambridge, Massachusetts University of Kentucky University of Mississippi Medical Center Lexington, Kentucky Jackson, Mississippi WENDY KOHRT, Ph.D. RICHARD F. LOESER, Jr., M.D. University of Colorado Health Science Center Wake Forest University School of Medicine HERNANDO OMBAO, Ph.D. P. HEMACHANDRA REDDY, Ph.D. Denver, Colorado Winston-Salem, North Carolina University of Illinois Oregon Health and Sciences University Champaign, Illinois Beaverton, Oregon CATHERINE M. KOTZ, Ph.D. VALTER D. LONGO, Ph.D. Veterans Affairs Medical Center/University of University of Southern California JUNKO OSHIMA, M.D., Ph.D. JOANNE ROBBINS, Ph.D. Minnesota Los Angeles, California University of Washington William S. Middleton VA Hospital Minneapolis, Minnesota Seattle, Washington University of Wisconsin, Madison KENNETH W. LYLES, M.D. Madison, Wisconsin DORA KOVACS, Ph.D. Duke University Medical Center ADAM PACK, Ph.D. Massachusetts General Hospital/Harvard Durham, North Carolina Utica College of Syracuse University JACK ROGERS, Ph.D. Medical School Utica, New York Harvard Medical School Boston, Massachusetts FERNANDO MACIAN, M.D., Ph.D. Charlestown, Massachusetts Albert Einstein College of Medicine MARCO PAHOR, M.D. BRUCE S. KRISTAL, Ph.D. Bronx, New York University of Florida College of Medicine SCOTT W. ROGERS, Ph.D. Burke Medical Research Institute Gainesville, Florida University of Utah White Plains, New York ROBERT MARCINIAK, M.D., Ph.D. Salt Lake City, Utah University of Texas Health Science Center DAVID PAIK, M.D. HARLAN KRUMHOLZ, M.D. San Antonio, Texas Columbia University MICHAEL ROSE, Ph.D. Yale University School of Medicine New York, New York University of California, Irvine New Haven, Connecticut GEORGE M. MARTIN, M.D. Irvine, California University of Washington School of Medicine OLIVIA M. PEREIRA-SMITH, Ph.D. GEORGE A. KUCHEL, M.D. Seattle, Washington University of Texas Health Science Center JOYCE A. RUBENSTEIN, Ph.D. University of Connecticut Health Center San Antonio, Texas Long Island University - CW Post Campus Farmington, Connecticut MARK MATTSON, Ph.D. Manhasset Hills, New York National Institutes for Health GEORGE PERRY, Ph.D. DONALD M. KUHN, Ph.D. National Institute of Aging Case Western Reserve University BART RYPMA, Ph.D. Wayne State University Baltimore, Maryland Cleveland, Ohio Rutgers University Detroit, Michigan Newark, New Jersey SKYE McDOUGALL, Ph.D. ROBERT B. PETERSEN, Ph.D. WALTER A. KUKULL, Ph.D. West Los Angeles VAMC GRECC Case Western Reserve University KATHRYN L. SANDBERG, Ph.D. University of Washington Los Angeles, California Cleveland, Ohio Georgetown University Medical Center Seattle, Washington Washington, DC RAVI MISRA, Ph.D. ERIC PETERSON, M.D., M.P.H. ALBERT LA SPADA, M.D., Ph.D., FACMG Medical College of Wisconsin Duke Clinical Research Institute JULIE SANDELL, Ph.D. University of Washington Milwaukee, Wisconsin Durham, North Carolina Boston University School of Medicine Seattle, Washington Boston, Massachusetts CHARLES V. MOBBS, M.D. PETER POMPEI, M.D. JAMES J. LAH, M.D., Ph.D. Mount Sinai School of Medicine Stanford University Medical Center NANETTE SANTORO, M.D. Emory University New York, New York Stanford, California Albert Einstein College of Medicine Atlanta, Georgia Bronx, New York SUMATHY MOHAN, Ph.D. DOMENICO PRATICO, M.D. PAMELA LARSEN, Ph.D. University of Texas Health Science Center at University of Pennsylvania MARTIN F. SARTER, Ph.D. University of Texas Health Science Center San Antonio Philadelphia, Pennsylvania University of Michigan San Antonio, Texas San Antonio, Texas Ann Arbor, Michigan 4 RALPH H. SAUNDERS, D.D.S. KAREN L. SWISSHELM, Ph.D. B.J. WAGNER, Ph.D. The University of Rochester University of Washington UMDNJ-New Jersey Medical School Rochester, New York Seattle, Washington Newark, New Jersey

DOUGLAS L. SCHMUCKER, Ph.D. GEORGE E. TAFFET, M.D. WALTER F. WARD, Ph.D. University of California at San Francisco Baylor College of Medicine University of Texas Health Science Center San Francisco, California Houston, Texas San Antonio, Texas

MICHAEL SEIDMAN, Ph.D. MARC TATAR, Ph.D. GORDON WARREN, Ph.D. National Institute on Aging Brown University Georgia State University National Institutes of Health Providence, Rhode Island Atlanta, Georgia Baltimore, Maryland DENNIS D. TAUB, Ph.D. BABETTE WEKSLER, M.D. YONG SHEN, M.D., Ph.D. National Institute on Aging Weill Medical School of Cornell University Sun Health Research Institute National Institutes of Health New York, New York Sun City, Arizona Baltimore, Maryland FLETCHER WHITE, Ph.D. BARBARA SHUKITT-HALE, Ph.D. J. ANDREW TAYLOR, Ph.D. Loyola University Medical Center Tufts University Spaulding Rehabilitation Hospital Maywood, Illinois Boston, Massachusetts Harvard Medical School Boston, Massachusetts DAVID L. WILSON, Ph.D. ALAN R. SHULDINER, M.D. University of Miami University of Maryland, Baltimore DARRYL G. THELEN, Ph.D. Coral Gables, Florida Baltimore, Maryland University of Wisconsin, Madison Madison, Wisconsin GLENN L. WILSON, Ph.D. FELIPE SIERRA, Ph.D. University of South Alabama National Institute of Aging D. PAUL THOMAS, Ph.D. Mobile, Alabama National Institutes of Health University of Wyoming Baltimore, Maryland Laramie, Wyoming DANIEL E. WOLLMAN, M.D., Ph.D. Center for Comprehensive Care RAM SIHAG, Ph.D. LA DORA THOMPSON, Ph.D. Shelton, Connecticut Food and Drug Administration University of Minnesota Bethesda, Maryland Minneapolis, Minnesota PHILIP C. WONG, Ph.D. The Johns Hopkins University School of DAVID A. SINCLAIR, Ph.D. JONATHAN L. TILLY, Ph.D. Medicine Harvard Medical School Massachusetts General Hospital Baltimore, Maryland Boston, Massachusetts Harvard University Boston, Massachusetts DIANA WOODRUFF-PAK, Ph.D. DAN F. SPANDAU, Ph.D. Temple University/Albert Einstein Medical Indiana University School of Medicine NIKOLAI TIMCHENKO, Ph.D. Center Indianapolis, Indiana Baylor College of Medicine Philadelphia, Pennsylvania Houston, Texas JANET R. SPARROW, Ph.D. WEIMING XIA, Ph.D. Columbia University JOHN G. TOWER, Ph.D. Harvard Institute of Medicine New York, New York University of Southern California Boston, Massachusetts Los Angeles, California JOSEPH W. STARNES, Ph.D. DEAN T. YAMAGUCHI, M.D., Ph.D. University of Texas, Austin BRUCE R. TROEN, M.D. VA Greater Los Angeles Healthcare System Austin, Texas University of Miami School of Medicine Los Angeles, California Miami, Florida JOHN R. STRATTON, M.D. RIQIANG YAN, Ph.D. University of Washington DEAN A. TROYER, M.D. The Cleveland Clinic Foundation Seattle, Washington University of Texas Health Science Center Cleveland, Ohio San Antonio, Texas WARREN J. STRITTMATTER, M.D. RAYMOND YUNG, M.D. Duke University Medical Center DENNIS A. TURNER, M.D. University of Michigan Durham, North Carolina Duke University Medical Center Ann Arbor, Michigan Durham, North Carolina JANET S. SUNNESS, M.D. MARCO ZARBIN, M.D., Ph.D. Johns Hopkins Wilmer Institute R. SCOTT TURNER, M.D. Ph.D. New Jersey Medical School Baltimore, Maryland University of Michigan Newark, New Jersey Ann Arbor, Michigan MARK SUPIANO, M.D. University of Michigan HOLLY VAN REMMEN, Ph.D. Ann Arbor, Michigan University of Texas Health Science Center San Antonio, Texas BETSY M. SUTHERLAND, Ph.D. Brookhaven National Laboratory GARY VAN ZANT, Ph.D. Upton, New York University of Kentucky Lexington, Kentucky PHILLIP D. SWANSON, M.D., Ph.D. University of Washington INEZ VINCENT, Ph.D. Seattle, Washington University of Washington Seattle, Washington 5 Gonzalo G. Garcia, Ph.D. Thomas J. Gould, Ph.D. University of Michigan Temple University AFAR Research Grant Effects of Surface Glycosylation in the Age- Investigation of Age-related Changes in related Decline of T-cell function Molecular Substrates of Learning in One- to two-year awards to junior faculty (M.D.’s and Ph.D.’s) to conduct Transgenic Mice research that will serve as the basis for longer term research efforts. Ming Guo, M.D., Ph.D. Sponsored by Individuals, Corporations and Foundations. David Geffen School of Medicine at the Mark Hoffman, Ph.D. University of California, Los Angeles Oregon State University Identifying Regulators of Gamma Secretase Reflex Modulation during Manipulation of Implicated in Alzheimer’s Disease the Sensory Systems

Wolfgang B. Liedtke, M.D., Ph.D. Daniel G. Herrera, M.D., Ph.D. Xudong Huang, Ph.D. 2005 Grantees Duke University Medical Center Weill Medical College of Cornell University Massachusetts General Hospital Molecular Pathogenesis of Osmotic Effects of Alcoholism on Neurogenesis in Homocysteine, Oxidative Stress and Rajendra S. Apte, M.D., Ph.D. Dysregulation by the Nervous System in the Aged Brain Mitochondria-dependent Neuronal Apoptosis Washington University Aging Mammals in Alzheimer’s Disease Aging and the Immune System: Implications Elizabeth Jonas, M.D. for Ocular Angiogenesis Jianyuan Luo, Ph.D. Yale University School of Medicine Mark Laubach, Ph.D. University of Massachusetts Medical School Enhancement of Synaptic Function by a The John B. Pierce Laboratory Stanley Thomas Carmichael, M.D., Ph.D. Negative Regulation of p53 Pathway by BCL-2 Family Protein Neurophysiological Correlates of Aging on David Geffen School of Medicine at the Mammalian Sir2 Antagonize p53 Dependent Reaction Time Performance University of California, Los Angeles Cell Senescence Induced by Oxidative Stress David E. Kang, Ph.D. Molecular Profile of Neuronal Regeneration University of California, San Diego Yi-Ju Li, Ph.D. in the Aged Brain after Stroke Barbara McCreadie, Ph.D. Role of Presenilin in Phosphorylation of Tau Duke University Medical Center University of Michigan Identification of Novel Age-at-Onset Genes Christopher J. Chang, Ph.D. Age-related Response to Trabecular Bone Brian K. Kennedy, Ph.D. on Chromosome 10 in Alzheimer’s Disease University of California, Berkeley Microdamage University of Washington Molecular Imaging Probes for Age-related Genome-wide Identification of Yeast Aging Philippe Marambaud, Ph.D. Oxidative Stress and Damage M. Paul Murphy, Ph.D. Genes Mount Sinai School of Medicine Mayo Clinic College of Medicine, Jacksonville Role of the Presenilin-1/ß-secretase Jim R. Fadel, Ph.D. Regulation of ß-Secretase by CNBP Christine Maric, Ph.D. Cleavage of E-Cadherin in Adherens University of South Carolina School of Georgetown University Medical Center Junction Functions Medicine Radhika H. Muzumdar, M.D. Estrogen Modulation of the Renin- Orexin Regulation of the Basal Forebrain Albert Einstein College of Medicine Angiotensin System in the Pathogenesis of David J. Moser, Ph.D. Cholinergic System in Aged Rats Role of Declining IGF-1 in the Metabolic Age-related Progressive Renal Disease University of Iowa Carver College of Medicine Syndrome of Aging Effects of Endothelial Dysfunction Insoo Kang, M.D. Kelly L. Tremblay, Ph.D. Cerebrovascular Disease, Cognition and Yale University School of Medicine Peter Penzes, Ph.D. University of Washington Depression The Effect of Aging on IL-7-mediated CD8+ Northwestern University Aging and the Neural Representation of T-cell Survival Regulation of Structural Plasticity of Speech-Sounds: Effects of Hearing Aid Susan R. Opalenik, Ph.D. Excitatory Synapses Amplification and Auditory Training Vanderbilt University Radhakrishnan Nagarajan, Ph.D. Stem Cells in Age-impaired Wound Healing University of Arkansas for Medical Sciences Pere Puigserver, Ph.D. Edwin J. Weeber, Ph.D. Modeling Changes in Myogenic Progenitor Johns Hopkins University School of Medicine Vanderbilt University Medical Center Giovanni Paternostro, M.D., Ph.D. Potential with Age Molecular Mechanisms for Transcriptional The Role of ApoE Receptors in Burnham Institute Regulation of Glucose Homeostatis Linked Hippocampal-dependent Synaptic Function Genetic Analysis of Cardiac Aging in Olav Rueppell, Ph.D. to Aging Drosophila University of North Carolina, Greensboro Gang Yu, Ph.D. Mitosis and Apoptosis in Relation to Lifespan Patrick M. Sullivan, Ph.D. University of Texas Southwestern Medical Qitao Ran, Ph.D. in the Honey Bee (Apis Mellifera L.) Duke University Medical Center Center University of Texas Health Science Center at Effective Aging on Brain ApoE-dependent, Dissecting Molecular Interactions of PEN-2 San Antonio Hongbing Wang, Ph.D. Lipid Metabolism in the ß-Secretase Complex Will Reduced Level of PHGPx (GPx4) in Michigan State University Brain Facilitate the Formation of Amyloid ß-Amyloid Precurson Protein-mediated Kaoru Tominaga, Ph.D. Plaques? Signaling Through FE65 University of Texas Health Science Center at San Antonio 2002 Grantees P. Hemachandra Reddy, Ph.D. Tian Wang, Ph.D. Analysis of MORF4 Functions In Vitro and In Oregon Health and Science University Yale University School of Medicine Vivo Model Systems Mary L. Bouxsein, Ph.D. Molecular Analysis of Synaptopodin Gene: A The Effect of Aging on Gamma Delta T-cell Beth Israel Deaconess Medical Center Possible Genetic Link with Late-onset The Role of ß-Arrestin2 in Regulating the Response to Nile Virus Infection in Mouse Zoltan Ungvari, M.D., Ph.D. Alzheimer’s Disease Model New York Medical College Effects of PTH in Bone Cardiovascular Protective Effects of Anti- Molly Shores, M.D. Francesco S. Celi, M.D. TNFa/TACE Treatment in Aging Veterans Affairs Puget Sound Health Care University of Maryland, Baltimore 2004 Grantees Type-2 Deiodinase Mutations and Insulin System David N. Zacks, M.D., Ph.D. The Effect of Testosterone Treatment on Resistance in the Old Order of Amish University of Michigan Kellogg Eye Center Depressive Symptoms and Quality of Life in Gal Bitan, Ph.D. Apoptosis in Photoreceptor Cell Death Brigham and Women’s Hospital/Harvard Linda L. Chao, Ph.D. Older Men with Age-associated Medical School University of California, San Hypogonadism and Subsyndromal Development of Amyloid ß-Protein Francisco/Veterans Affairs Medical Center Depression Oligomerization Inhibitors 2003 Grantees fMRI of Attention and Inhibitory Control in Normal Aging Adrian M. Timmers, Ph.D. Bo-Chin Chiu, Ph.D. Douglas E. Faunce, Ph.D. University of Florida University of Michigan Loyola University Medical Center Paola Fabrizio, Ph.D. Accumulation of Age-pigment in Retinal Effect of Aging on Early Events of A Role for Natural Killer T-cells in Age-relat- University of Southern California Pigment Epithelium and Age-related Macular Pulmonary Innate Immune Response to ed Immune Dysfunction The Role of Evolutionary Conserved Proteins Degeneration Mycobacterial Antigen Challenge in Mouse in Yeast Longevity Models 6 * Institution affiliation at time of award listed Heidi A. Tissenbaum, Ph.D. Maricarmen Planas-Silva, Ph.D. Esther Dupont-Versteegden, Ph.D. Aziz M. Ulug, Ph.D. University of Massachusetts Medical School Penn State University College of Medicine Donald W. Reynolds Center on Aging at the Weill Medical College of Cornell University Genetic and Molecular Analysis of Estrogen Receptor Expression and Function University of Arkansas Medical School The Diagnosis and Management of Normal Mechanisms Controlling Life Span in in the Aging Mammary Gland The Role of Calcineurin in Age-associated Pressure Hydrocephalus in the Elderly Using C. elegans Muscle Atrophy MRDTI Troy T. Rohn, Ph.D. Boise State University David A. Goukassian, M.D., Ph.D. Demetri Vassilatis, Ph.D. The Role of Caspase-8 in Mediating Boston University School of Medicine Baylor College of Medicine 2001 Grantees Neuronal Cell Death Associated with The Effect of Aging on DNA Repair and Caenorhabditis elegans as a Model for Alzheimer’s Disease: A Potential Therapeutic Mutation Rate: Modulation by DNA Parkinson’s Disease Christy S. Carter, Ph.D. Target Oligonucletide Therapy Wake Forest School of Medicine Robert West, Ph.D. Physical Ability in Aged and Dwarf(dw/dw) Patricia W. Slattum, Pharm.D., Ph.D. Claudia Gravekamp, Ph.D. University of Notre Dame Rats: Isolating Growth Hormone Effects Virginia Commonwealth University Cancer Therapy and Research Center The Neural Foundation of Age-related Age-related Differences in the Sensitivity A Syngeneic Mouse Tumor Model to Declines in Prospective Memory John P. Case, M.D. and Development of Acute Tolerance to Develop Cancer Vaccines for the Elderly Rush-Presbyterian-St. Luke’s Medical Center Ethanol in Humans Asma Zaidi, Ph.D. Relationship between Dynamic Joint Qing Guo, Ph.D. University of Kansas Loading, Bone Mineral Density, and Sundar Srinivasan, Ph.D. Northeastern Ohio Universities School of Age-related Alterations in the Plasma Radiographic Predictors of Early University of Washington Medicine Membrane Ca2+-ATPase: Role of Oxidative Osteoarthritis in the Elderly Rest-inserted Loading: Examination of a Inhibiting Aberrant Processing of Stress and Ceramide Signaling Novel Osteogenic Stimulus for the Aged Alzheimer’s ß-Amyloid Precursor Protein by Atanu Duttaroy, Ph.D. Skeleton Blocking Par-4 Activity: Novel Therapeutic Howard University Implications in the Treatment of Alzheimer’s Genomic Regions Involved in Manganese 1999 Grantees Mei Sun, Ph.D. Disease Superoxide Dismutase Regulation in West Roxbury Veterans Affairs Drosophila Ayotunde S.O. Adeagbo, Ph.D. Hospital/Harvard Medical School Paul S. Hees, Ph.D. University of Louisville Developing Gene Therapy for Parkinson’s Johns Hopkins Bayview Medical Center The Aging Factor in Potassium Cycling and Peter Erhardt, M.D., Ph.D. Disease Using Helper Virus-free HSV-1 Reversal of Age-related Myocardial Stiffness Blood Vessel Relaxation Boston Biomedical Research Institute Vectors in Rats Regulation of Cardiomyocyte Survival by MDM2 Nancy J.O. Birkmeyer, Ph.D. Ruben G. Vidal, Ph.D. Shurong Huang, Ph.D. Dartmouth University Indiana University School of Medicine Palo Alto Institute of Molecular Medicine A National Study of Aortic Valve Karen Furie, M.D., M.P.H. The BRI Gene Family and Familial British Regulation of Replicative Senescence by the Replacement in the Elderly Spaulding Rehabilitation Hospital and Danish Dementia WRN Gene Apolipoprotein E Genotype and Functional William J. Bowers, Ph.D. Recovery Following Rehabilitation after Suresh Viswanathan, M.S., Ph.D. Jennifer I. Luebke, Ph.D. Ischemic Stroke University of Rochester School of Medicine & Indiana University School of Optometry Boston University School of Medicine Dentistry Identifying the Retinal Loci of Age-related Functional Consequences of Cholinergic Improved HSV Amplicon Vectors for Long- ZhongMao Guo, M.D., Ph.D. Changes in Rod-mediated Visual Function Degeneration in Aged Rhesus Monkeys Meharry Medical College term Treatment of Parkinson’s Disease Does Calorie Restriction Retard Beverly M. Yashar, M.S., Ph.D. Allen Mandir, M.D., Ph.D. Atherosclerosis in Transgenic Mice? Holly M. Brown-Borg, Ph.D. University of Michigan Johns Hopkins University University of North Dakota Molecular Genetics Studies of Age-related Aging & Parkinson’s Disease: MPTP Models Anti-oxidative Mechanisms and Damage David F. Jarrard, M.D. Macular Degeneration of Neurotoxicity University of Wisconsin Resistance in a Mouse Model of Delayed Aging Genomic Imprinting Alterations in Clare E. Yellowley, Ph.D. Michael J. McEachern, Ph.D. Senescence Penn State University College of Medicine University of Georgia Michelle C. Carlson, Ph.D. Interactions of Age and Ovariectomy on Genomic Screen for Telomere Mutants Johns Hopkins University Dawn A. Lowe, Ph.D. Bone Cell Mechanosensitivity: Recovery by Regular Mental Activity and Cognitive University of Minnesota PTH Administration Timothy P. O’Connor, Ph.D. Function in Older Adults Molecular Mechanism of Age-related City College of the City University of New York Declines in Muscle Contractility Aging of Gut Function and Metabolism in a Monique M. Cherrier, Ph.D. Long-lived Rodent, the Naked Mole-Rat Gianni F. Maddalozzo, Ph.D. 2000 Grantees University of Washington Androgen Effects on Cognition in Healthy Oregon State University Riccardo Perfetti, M.D., Ph.D. Older Men The Separate and Combined Effect of James A. Carson, Ph.D. Cedars-Sinai Medical Center Estrogen Replacement Therapy (ERT) and University of South Carolina Age-dependent Decline of Pancreatic Islet Jeff C. Falcone, Ph.D. Resistance Training on the Musculoskeletal Serum Response Factor’s Role in Aged Cell Function is Reversed by Hormonal University of Louisville and Nervous System in Early Skeletal Muscle’s Blunted Remodeling Treatment Postmenopausal Women Response to Chronic Stretch Vascular Myogenic Responses and Aging: Orthostatic Hypotension or Hypertension? Suzana Petanceska, Ph.D. Robert Moir, Ph.D. Qin Mary Chen, Ph.D. Nathan Kline Institute Deborah A. Ferrington, Ph.D. Massachusetts General Hospital University of Arizona Modeling the Role of Microglia in ß ␣ University of Minnesota LRP-mediated Uptake of Redox Modified AD Molecular Mechanisms of Oxidative Stress Deposition: Effect of Estrogen Associated Proteins Response in Cardiomyocytes The Role of the Proteasome Proteolytic Pathway in Muscle Plasticity with Aging David A. Sinclair, Ph.D. Laura E. Niklason, M.D., Ph.D. Charleen T. Chu, M.D., Ph.D. Harvard Medical School Lee Goodglick, Ph.D. Duke University Medical Center University of Pittsburgh A Molecular Role for Werner and Sgs1 University of California, Los Angeles Telomerase in Engineered Vascular Tissues Superoxide and Nitric Oxide in a Helicases in Telomere Maintenance and Identification of an Antigen Associated with Parkinsonian Mouse Model Premature Aging Claudia A. Orengo, M.D., Ph.D. the Pathogenesis of Giant Cell Arteritis Baylor College of Medicine Ana Maria Cuervo, M.D., Ph.D. Nina J. Solenski, M.D. Testosterone Augmentation in Depressed Albert Einstein College of Medicine Jean X. Jiang, Ph.D. University of Virginia Health System University of Texas Health Sciences Center at Men with Partial Response to Anti-depres- Changes in the Lysosomal Receptor for The Role of Mitochondria in Hypoxia- San Antonio sant Therapy Chaperone-mediated Autophagy with Age induced Cell Death Estrogen and Intercellular Communication in Bone Osteocytes 7 Ming-Tao Jiang, Ph.D. Kristine Krajnak, Ph.D. University of Wisconsin-Madison 1998 Grantees University of Kentucky 1997 Grantees Properties of Calcium Release Channels and Effects of Aging and Estrogen on 5HT Their Regulation by ß-adrenergic Stacey M. Anderson, M.D. Neural Activity and its Regulation of Robert D. Blank, M.D., Ph.D. Stimulation in the Aged Rat Heart University of Virginia Activity/Rest Rhythms The Hospital for Special Surgery Altered Regulation of Human Growth Genetics of Bone Mineral Content and Nori Kasahara, M.D., Ph.D. Hormone Secretion in Postmenopausal Valter D. Longo, Ph.D. Quality in Inbred Mice: Analysis of the University of Southern California Estrogen Deficiency University of Southern California HcB/Dem Recombinant Cogenic Strain Set Investigating the Role of Klotho as a Identification of Chronological Longevity Humoral Factor Implicated in Age-related Katrin Andreasson, M.D. Assurance Genes in Yeast Cheong-Hee Chang, Ph.D. Disease Pathogenesis Johns Hopkins University School of Medicine University of Michigan Function of Cyclooxygenases in Neuronal Lisa M. Miller, Ph.D. Regulation of IL-4 Production and its Role Cathy Kotz, Ph.D. Injury Albert Einstein Center for Synchrotron in Aging University of Minnesota Biosciences Effect of Age on Orexin-containing Neural Ben A. Bahr, Ph.D. Understanding the Chemical Composition of Robert F. Clark, Ph.D. Pathways University of Connecticut School of Pharmacy Osteoarthritic Bone Meharry Medical College Influences of Aging Processes on Glutamate Characterization of the Drosophila Presenilin John Larson, Ph.D. Receptor Modification and Regulation in a Thomas J. Montine, M.D., Ph.D. Gene University of Illinois at Chicago Model System Vanderbilt University Neurobiology of Aging in the Mouse Lipid Peroxidation and APOE in Alzheimer’s Lisa Tabor Connor, Ph.D. Olfactory System Partha P. Banerjee, Ph.D. Disease Boston University School of Medicine Johns Hopkins University School of Hygiene & Modulators of Lexical Retrieval Failure in Carl W. Luchies, Ph.D. Public Health Susumu Mori, Ph.D. Old Age University of Kansas Roles of Androgen and Estrogen in Age- Johns Hopkins University Age Effects on Postural Control dependent Development of Prostatic Brain Fiber Tracking in Alzheimer’s Disease Timothy E. Curran, Ph.D. Mechanisms: The Upper Extremities Intraepithelial Neoplasia and Prostate by Magnetic Resonance Imaging Case Western Reserve University Cancer in Brown Norway Rat Event-related Potentials of Sensory Mathew Maurer, M.D. Shin Murakami, Ph.D. Underload Columbia University Alexandra L. Basolo, Ph.D. University of Colorado, Boulder Orthostatic Hypotension and Falls in University of Nebraska-Lincoln Molecular Mechanisms for Regulation of Adriana Ferreira, M.D., Ph.D. Nursing Home Residents: Is Diastolic Blood Pleiotropic Effects of a Gene Determining Lifespan and Increased Resistance to Northwestern University Regulation of Neuronal Kinase Activity by ß- Pressure Changes More Predictive than Age and Size at Sexual Maturation Environmental Stresses in C. elegans Amyloid Changes in Systolic Blood Pressure? Maria L. Burgess, Ph.D. Daniel A. Peterson, Ph.D. Craig Neville, Ph.D. University of Illinois Salk Institute for Biological Studies Roger A. Fielding, Ph.D. Massachusetts General Hospital Intergrin Expression and Second Signaling Prevention of Neuronal Cell Death in the Boston University A Comparison of Progressive Resistance Mitigation of the Effects of Sarcopenia in the Adaptation of Cardiac Fibroblasts to Entorhinal Cortex Advancing Age Training and High Velocity Muscle Power David C. Paik, M.D. Blanka Rogina, Ph.D. Training on Changes in Muscle Strength, Columbia University Noel Y. Calingasan, D.V.M., Ph.D. University of Connecticut Health Center Histology and Function in Frail Older The Non-enzymatic Nitration of Collagen in Burke Medical Research Institute Cloning Two Genes with Different Regulation Women Human Vascular Aging A Test of How Aging Alters the Interaction of Expression during Aging between Oxidative Stress and Nutritional Mary Kay Francis, Ph.D. Emily D. Richardson, Ph.D. Deficit Edward M. Schwarz, Ph.D. Allegheny University of the Health Sciences University of Colorado, Boulder University of Rochester EPC-1 Expression and Aging: Effect on Visual Attention Training for At-risk Older Susana T.L. Chung, Ph.D. Gene Therapy for Arthritis in the hTNF ß- Proliferation Drivers: A Pilot Intervention Indiana University Transgenic Mouse Optimizing Peripheral Reading Speed in Katsutoshi Furukawa, M.D., Ph.D. Bart Rypma, Ph.D. Older Americans with Age-related Mary Seeger, Ph.D. University of Kentucky University of Pennsylvania Maculopathy Rockefeller University Functions of Presenilin Mutations in Ion Neural Correlates of Age-related Differences ß-Secretase Cleavage of Alzheimer Amyloid Homeostasis of Neuronal Cells in Working Memory Nicola S. Clayton, Ph.D. Precursor Protein in Yeast University of California, Davis Jeffrey M. Hausdorff, Ph.D., MSME Stuart N. Seidman, M.D. The Role of Brain Estrogens in Age-induced Christian Sell, Ph.D. Beth Israel Deaconess Medical Center/Harvard Columbia University Memory Loss: A New Animal Model Allegheny University of the Health Sciences Medical School Testosterone and Depression in Men The Role of Phosphatidylinositol 3-kinase in Fall Risk Assessment: A Prospective Study Igor M. Dozmorov, Ph.D. Cellular Senescence of the Relationship between Gait Instability Caryl E. Sortwell, Ph.D. University of Michigan and Falls in the Elderly Rush-Presbyterian-St. Luke’s Medical Center Antagonistic Interactions Among T-cell Jie Shen, Ph.D. Trophic Inhibition of Apoptosis in Subsets and Age-associated Harvard University Chun Huang, Ph.D. Mesencephalic Grafts to Aged Rats Immunodeficiency Functional Characterization of Presenilin-1 Hawaii Osteoporosis Foundation Wild-type and Mutant Alleles in Mice The Impact of Osteoporotic Fractures on Michael J. Toth, Ph.D. Narayanasamy Elango, Ph.D. Physical Function and Quality of Life Among University of Vermont University of Texas Health Science Center at Pamela E. Souza, Ph.D. the Elderly Skeletal Muscle Protein Metabolism in Heart San Antonio University of Washington Failure Patients Differentiation of Bone Marrow Osteoblast Use of New Hearing Aid Processing Michael Jakowec, Ph.D. Progenitor Cells: Analysis of Genetic Strategies by Elderly Adults Parkinson’s Institute Scott D. Webster, Ph.D. Determinants of Age-related Bone Loss The Molecular Mechanisms Underlying University of California, Irvine Mary A. Whooley, M.D. Enhanced Sensitivity to MPTP in Old Amyloid Phagocytosis in Microglial: Andrea C. Gore, Ph.D. University of California, San Francisco Squirrel Monkeys Contributions to Alzheimer’s Pathogenesis Mount Sinai School of Medicine Estrogen Therapy and Depression in Elderly Neuroendocrine Control of Reproductive Women Aging

Lynn Harrison, Ph.D. Louisiana State University Medical Center Investigation into the Role of Nuclear and 8 Mitochondrial DNA Damage in Cellular Senescence Dean Kellogg, Jr., M.D., Ph.D. William T. Lee, Ph.D. University of Texas Health Science Center at 1996 Grantees David Axelrod Institute 1995 Grantees San Antonio The Relationship between Memory T Effects of Reproductive System Aging on Namanjeet Ahluwalia, Ph.D. Lymphocytes and Aging John M. Abrams, Ph.D. Pennsylvania State University University of Texas Southwestern Medical Endothelial Mechanisms of Vasoconstriction Plasma Transferrin Receptors in the Elderly Center and Vasodilation in Women Xipu Liu, M.D., Ph.D. as a Biomarker for Iron Deficiency: Allegheny University of the Health Sciences Apoptosis and Aging in Drosophila Daniel E. Lieberman, Ph.D. Establishing Normative Range and Cut-off RPE-controlled Choriocapillary Endothelial Michael E.T.I. Boerrigter, Ph.D. Rutgers University Apoptosis: Relevance of Choriocapillary Harvard Medical School Effects of Age and Exercise on Cortical Bone Dora Monica Berman, Ph.D. Atrophy in Age-related Macular University of Maryland, Baltimore DNA Repair and Mutations in Relation to Growth and Porosity Degeneration Cellular Mechanisms Underlying Visceral Aging in a New LacZ Plasmid-based Ravindra P. Misra, Ph.D. Obesity in Postmenopausal Women: Effects Laura J. Mauro, Ph.D. Transgenic Mouse Model Medical College of Wisconsin of Weight Loss University of Minnesota Medical School Molecular Mechanism of Cell Activation by Parathyroid Hormone Regulation of a Bone Richard M. Cawthon, M.D., Ph.D. University of Utah Calcium-containing Crystals Diane M. Biskobing, M.D. Tyrosine Phosphatase Emory University Genetic Variation at Antioxidant Loci, Age Mariana N. Nikolova-Karakashian, Ph.D. Prevention of Bone Resorption Through Daniel Promislow, Ph.D. Upon Diagnosis of First Tumor, and Human Emory University Inhibition of Osteoclast Activity University of Georgia Longevity Sphingolipid Metabolism and Signaling in The Effect of Retroviral-like Elements on Aged Male Rats: Relation to Inflammatory Abraham Brown, Ph.D. Age-specific Mortality Rates Beth Ann Derfus, M.D. Burke Medical Research Institute Medical College of Wisconsin Response and Regulation of Cell Growth Requirement for Membrane Association in Jack T. Rogers, Ph.D. Prevention of the Destructive Calcium Sergey V. Nuzhdin, Ph.D. the Processing of Alzheimer’s Precursor Harvard Medical School Crystal Arhritides of Aging University of California, Davis Protein by ß-secretase Amyloid Precursor Protein mRNA The Genetic Basis of Modification of Translation by Interleukin-1 and Alzheimer’s Mark D’Esposito, M.D. University of Pennsylvania Lifespan by an Individual’s Life History in Mary Patricia Corr, M.D. Disease University of California, San Diego Working Memory in Normal Human Aging Drosophila melanogaster CD1-mediated Regulation of T-cell Effector William A. Sather, Ph.D. Tekum Fonong, Ph.D. Junko Oshima, M.D., Ph.D. Function Using Gene Therapy University of Colorado Health Sciences Center University of Maryland, Baltimore Molecular Composition of Neuronal Calcium University of Washington Low Levels of Energy Expenditure in Older Consequences of Werner Helicase Gene Rebecca L.W. Corwin, Ph.D. Channels during Aging Pennsylvania State University African-American Women: A Predisposing Mutations on Expression of its mRNA and Influence of Serotonin on Nutritional Status Factor in the Development of Obesity? Protein Biao Shi, Ph.D. in Aging University of California, Davis Sally R. Frenkel, Ph.D. Joseph P. Pierce, Ph.D. Altered PI/PKC Signaling Pathway in Aged Matthew P. Frosch, M.D., Ph.D. New York University School of Medicine Cornell University Medical College Human Keratinocytes Harvard Medical School The Effects of Nitric Oxide on Cartilage In Neuroanatomical Alterations in Hippocampal Transgenic Mouse Models for Early-Onset Vitro and In Vivo: Implications for Arthritis Pathways Associated with Learning and Teresa Sobreviela, M.D., Ph.D. Alzheimer’s Disease Memory Deficits in Aged Rats Rush-Presbyterian-St. Luke’s Medical Center NGF Transport and trk Expression in Aged Luc E. Gosselin, Ph.D. Marc J. Glucksman, Ph.D. State University of New York at Buffalo Domenico Pratico, M.D. Rat Towards a Novel Therapy for Age-relat- Mount Sinai School of Medicine Age-associated Susceptibility to Muscle ed Cognitive Decline University of Pennsylvania Functional Analyses of ß-Secretase Injury: Relationship to Muscle Stiffness and Isoprostanes, Oxidative Damage and (EP2415) in Alzheimer’s Disease Collagen Cross-linking Alzheimer’s Disease Hinrich Staecker, M.D., Ph.D. Albert Einstein College of Medicine Patrick R. Hof, M.D., Ph.D. Shelley L. Halpain, Ph.D. Tracy G. Ram, Ph.D. Prevention of the Loss of Auditory Neurons Mount Sinai School of Medicine University of Virginia in a Mouse Model of Presbycusis (C57B1) Washington State University School of Retinal Ganglion Cell Vulnerability in a Non- Aging and Neural Plasticity: Regulation of Strain by Neurotrophin-3 (NT-3 Biological Science human Primate Model of Glaucoma Cytoskeletal Proteins Paracrine Action of Heregulins in the Aged Administration to the Inner Ear via a Viral Mammary Gland Karen Hubbard, Ph.D. Vector [HSV Nt31ac]) Stephen L. Helfand, M.D. City College of City University of New York University of Connecticut Health Center Cynthia Sites, M.D. Post-transcriptional Processing in Cellular Wenn H. Sun, Ph.D. Control of Gene Expression during Aging University of Vermont Aging Northwestern University Hormone Replacement Therapy and Molecular Mechanisms of Age-associated Jody L. Jensen, Ph.D. Metabolic Cardiovascular Risk Gursurinder P. Kaur, Ph.D. Interleukin-6 Dysregulation in Post- University of Oregon Temple University School of Medicine menopausal Osteoporosis Biomechanical Correlates of Age-related Nikolai Timchenko, Ph.D. Genetics of Cell Senescence: Mapping of Changes in the Neural Control of Balance Baylor College of Medicine Cellular Senescence Genes on Human Mark Tatar, Ph.D. Studies of the Molecular Basis for Loss of Chromosomes University of Minnesota Richard S. Jones, Ph.D. Regenerative Capacity with Age-effect of Mapping Genes for Mortality with Southern Methodist University Aging on C/EBP Alpha Mediated Control of Ichiro Kawachi, M.D., Ph.D. Transposable Element Markers in Drosophila Telomere Organization and Aging Liver Proliferation Harvard University School of Public Health melanogaster Social Networks and Healthy Aging: A Kathleen K. Kaysinger, Ph.D. Qi-hui Zhai, M.D., M.Sc. Prospective Study Darryl G. Thelen, Ph.D. Carolinas Medical Center Medical College of Ohio Hope College Interactions of Aging and Estrogen on Tumor Necrosis Factor in Cerebral Ischemia Evan T. Keller, D.V.M., Ph.D. Mechanisms of Balance Recovery during Osteoblast Function in Aged Rat East Virginia Medical School Falls: Age Effects Androgen’s Effect on Interleukin-6 Lei Li, Ph.D. Expression in Bone Cell Lines: Developing a Huaxi Xu, Ph.D. University of Texas M.D. Anderson Cancer Molecular Model for Osteoporosis Rockefeller University Center Regulation of Alzheimer ß-Amyloid Analysis of Nucleotide Excision Repair Virginia B. Kraus, M.D., Ph.D. Metabolism by Signal Transduction Defect in Hutchinson-Gilford Progeria Duke University Medical Center Regulation of Metalloproteinases in R. Lee Mosley, Ph.D. Osteoarthritis University of Michigan Medical Center Frequency and Expansionary Potential of Post-thymic T Stem Cells from Aged Mice 9 Karen Diane Parfitt, Ph.D. Jonathan Day, Ph.D. Skye McDougall, Ph.D. Yaotang Wu, Ph.D Pomona College Pennsylvania State University University of California, Los Angeles Children’s Hospital, Harvard Medical School Changes with Aging in Cyclic AMP-depend- Plasticity in the Aging Rat Hippocampus The Role of TWIST in Controlling Type II Solid State NMR Study of Osteoporotic ent Synaptic Transmission and Synaptic Collagen Gene Expression in Chondrocytes Bone Plasticity in Rat Hippocampus Kottarappat Dileepan, Ph.D. and the Development of Osteoarthritis University of Kansas Medical Center Donna Zimmaro Bliss, R.N., Ph.D. Jharna Ray, Ph.D. Protective Effects of Heparin on Vascular Todd Morgan, Ph.D. University of Minnesota Cornell University Endothelium Research University of Southern California Dietary Fiber Therapy for Fecal Incontinence Age-related Alteration in Retinal Pigment TGF-B1 and the Microglial Response to Epithelial Metabolism - Significance to Age- Pamela Fink, Ph.D. Aging related Macular Degeneration University of Washington T-cell Receptor Repertoire in CD4-CD8- Ramagopal Mudumbi, Ph.D. 1993 Grantees Peripheral T-cells from Aged Mice Veterans Affairs Medical Center, Boise G. William Rebeck, Ph.D. Diana Bigelow, Ph.D. Aging & Vascular Pharmacology of Harvard Medical School University of Kansas Analysis for ApoE Mutations Affecting the Lorise Gahring, Ph.D. Adenosine Effects of Protein & Lipid Oxidation on Risk of Alzheimer’s Disease University of Utah Intracellular Calcium Regulation Age-related Changes in Inflammatory Lauren Nathan, M.D. Cytokine Expression in the Brain David Geffen School of Medicine at the Michael Sierks, Ph.D. Gregory Boyarsky, Ph.D. University of Maryland, Baltimore University of California, Los Angeles University of Texas Medical Branch Artificial Antibodies for Diagnosis and Pamela Ann Gayheart, Ph.D. The Effects of Conjugated Equine Estrogens Regulation of Intracellular pH in Single Treatment of Alzheimer’s Disease Medical College of Pennsylvania on Coronary Blood Flow The Effects of Myocardial Ischemia on the Senescent Vascular Smooth Muscle Cardiac Sympathetic Nervous System of the John R. Silber, Ph.D. Usha Ponnappan, Ph.D. Judy Brunso-Bechtold, Ph.D. Aging Heart University of Washington University of Arkansas for Medical Sciences Bowman Gray School of Medicine at Consequences of Age-dependent Loss of the Aging and Immune Function Role of Wake Forest University DNA Repair Protein O6-Methylguanine-DNA Garth Hall, Ph.D. Transcription Factor NFKB Effects of Dietary Restriction on Methlytransferase in Human Brain University of Pennsylvania Cerebovascular and Neural Aging Phosphorylation of Tau Protein in Identified Marko Radic, Ph.D. Lamprey Neurons: A Cellular Model for the Medical College of Pennsylvania Mark A. Smith, Ph.D. Mary Lou Caspers, Ph.D. Cytopathology of Alzheimer’s Disease Molecular Basis for the Declining Antibody Case Western Reserve University University of Detroit-Mercy Markers of Oxidative Stress in Aging and Response in Aging Influence of Estrogen on High Affinity Neurodegenerative Disease Ahmad Heydari, Ph.D. Choline Uptake during Aging University of Texas Health Science Center at May J. Reed, M.D. San Antonio University of Washington J. Andrew Taylor, Ph.D. Kathryn Clark, Ph.D. Does Caloric Restriction Alter Transcription Aging, Caloric Restriction and Wound Harvard Medical School University of Michigan Effect of Age and Hypertension on of Specific Genes at the Level of Repair Regulation of Cytochrome c with Oxidase Baroreflex-mediated Autonomic Outflow Transcription Factors? Gene Expression in Aging Skeletal Muscle Chandar Singaram, M.B. University of Wisconsin-Madison Guochuan Tsai, M.D., Ph.D. Eric Howard, Ph.D. Lucian Del Priore, M.D., Ph.D. Pathogenesis of Esophageal Dysmotility in Harvard Medical School University of Oklahoma Health Sciences Center Washington University School of Medicine A Pilot Study of D-cycloserine in Alzheimer’s Matrix Metalloproteinases in Bone Stromal the Elderly Transplantation of Retinal Pigment Disease Cells Epithelium Charles Soparkar, M.D., Ph.D. Baylor College of Medicine Christopher H. van Dyck, M.D. David Hurley, Ph.D. Michele Didier, Ph.D. Enhancing the Vascularization of Orbital Yale University School of Medicine Tulane University McLean Hospital Motor Correlates of Striatal Dopamine Growth Hormone Releasing Hormone Bone Substitutes: A Model for the Study of Molecular Characterization of Glutamate Transporter Binding with [123I] ß-CIT Transcriptional Regulation in Aging Changes in Angiogenesis and Aging Receptor Subunits in Neurodegeneration SPECT in Older Adults Mary King, M.D. Eugenia Spanoupolou, Ph.D. Meika A. Fang, M.D. Holly Van Remmen, Ph.D. University of Connecticut Health Center Rockefeller University Veterans Affairs Medical Center, West Los Do Postural Stability Limits Predict Dynamic Age-related Loss of Immunoglobin Diversity University of Texas Health Science Center at Angeles Balance Responses? & the Role of RAG-1 in the Bone Marrow San Antonio The Role of EGR-1 in Prostaglandin E2 Production of Transgenic Mice Lymphocytes of Elder Mice Mediated Signal Transduction and Overexpressing Catalase and Superoxide Qian Li, Ph.D. Proliferation of Osteoblastic Cells Dismutase: A Model to Test the Free Radical University of California, San Francisco Pericles Stavropoulos, Ph.D. Effects of Aging on Voltage-dependent Ion Boston University Theory of Aging Thomas C. Foster, Jr., Ph.D. Channels in Myocardial Cells Synthesis of CuZnSOD Mimics as Potential University of Virginia Probes of Age-related Oxidative Damage Richard E. White, Ph.D. Neurobehavioral Relations of the Senescent Brian Richard MacDonald, M.B., CHB, Wright State University School of Medicine Hippocampus Female Sex Hormones Prevent Age-induced Ph.D. Giulio Taglialatela, Ph.D. Hospital of the University of Pennsylvania University of Texas Medical Branch Cardiovascular Dysfunction Barry Gumbiner, M.D. A Cellular and Molecular Analysis of Neurotrophins Rescue of Apoptotic Neural University of Rochester Osteoblast Differentiation Cells Insulin Signal Transduction in Aging 1994 Grantees Susan Marengo, Ph.D. W. Robert Taylor, M.D., Ph.D. Eun-soo Han, Ph.D. Case Western Reserve University School of Veterans Affairs Medical Center, Decatur University of Texas Health Science Center at Nir Barzilai, M.D. Mechanisms of Age-related Impairment of Medicine San Antonio Albert Einstein College of Medicine Stimulation of Growth of the Prostatic Endothelial Function Estrogen-dependent Gene Expression in the Aging Effects on Peripheral and Hepatic Stroma by the Prostatic Epithelium: A Aging Brain Glucose Metabolism Possible Role for a Paracrine Pathway in the Jonathan Tilly, Ph.D. Johns Hopkins University Development of BPH Robert H. Helfert, Ph.D. Bysani Chandrasekar, D.V.M., Ph.D. The Molecular Basis of Female Reproductive Southern Illinois University School of Medicine University of Texas Health Science Center at Daniel McCarty, M.D. Aging & Menopause San Antonio Alterations in the Synaptic Organization of the Medical College of Wisconsin Inferior Colliculus of Aging Fischer 344 Rats Modulation of Age-associated Loss in A Quantitative Approach to Inorganic Elias Traboulsi, M.D. Kidney Function by Calorie Restriction Johns Hopkins University Pyrophosphate Metabolism Pamela L. Larsen, Ph.D. Mapping the Gene(s) for Chronic Open University of Missouri, Columbia Angle Glaucoma (COAG) 10 A Molecular Genetic Approach to Efficient Life Maintenance Edward J. Lesnefsky, M.D. Jeffrey Zachwieja, Ph.D. Joyce B. Harp, M.D. Kathryn V. Porrello, Ph.D. Case Western Reserve University Washington University School of Medicine Emory University School of Medicine Doheny Eye Institute Ischemic Injury in the Aging Heart Role of Glutamine in Skeletal Muscle Protein The Renin-Angiotensin System in Adipose Retinal Cytoskeletal Alterations in Aging and Synthesis: Is There an Age-related Effect? Tissue from Aging Spontaneously in Alzheimer’s Disease Victoria Lundblad, Ph.D. Hypertensive Rats Baylor College of Medicine Michael Zagorski, Ph.D. Karen M. Prestwood, M.D. Characterization of an Alternate Pathway for Case Western Reserve University Stephen L. Helfand, M.D. University of Connecticut Health Center Telomere Maintenance and its Role in Sequence Specific pKa Measurements of the University of Connecticut Health Center The Relationships of Bone Turnover and Cellular Senescence Amyloid ß-Peptide Found in Alzheimer’s Regulation of Gene Expression during Aging Bone Loss in Women 70 Years and Older Disease Marco Marcelli, M.D. Lenore Holte, Ph.D. Julio A. Rimarachin, M.D. Baylor College of Medicine Syracuse University Cornell University Medical College Establishment of an Experimental Model to The Effects of Aging on Multi-frequency Age-related Arterial Intimal Hyperplasia Study the Development of Hormone 1992 Grantees Tympanograms Unresponsive Prostate Cancer Ann K. Rosenthal, M.D. Nancy L. Baenziger, Ph.D. Joel Horwitz, Ph.D. Medical College of Wisconsin Geraldine M. McCarthy, M.D. Washington University School of Medicine Medical College of Pennsylvania Aging, TGF ß and CPPD Crystal Deposition Relationship of Bradykinin Receptor Medical College of Wisconsin Phosphatidylcholine Hydrolysis in the Aging Disease Calcium-containing Crystal Deposition Expression to Cellular Senescence in an In Rat Arthritis and Aging Vitro Model of Aging Alan R. Salkind, M.D. Bradley T. Hyman, M.D., Ph.D. University of Mississippi Medical Center Laurie McCauley, Ph.D., DDS Neil C. Binkley, M.D. Massachusetts General Hospital Human Aging and Leukocyte Senescence University of Michigan University of Wisconsin-Madison Are Nitric Oxide Synthase Neurons Spared Aging and Parathyroid Hormone (PTH) Effect of Interleukin-6 on Bone of Middle- in Alzheimer’s Disease? David R. Sell, Ph.D. Function: Effects of Estrogen on PTH aged and Old Rhesus Monkeys Case Western Reserve University Receptors in Bone Philip E. Keeting, Ph.D. Pentosidine as a Biomarker for Cellular John N. Buchholz, Ph.D. West Virginia University Aging of Human Skin Fibroblasts in Culture Daniel Muller, M.D. University of California, Irvine College of Steroid Hormone Effects on Human University of Wisconsin Medicine Osteoblastic Cell Interleukin-1 Production Ram K. Sihag, Ph.D. Aging Calorie Restriction and the Immune Effect of Age on Control of Norepinephrine Harvard Medical School Response to Viral Infection Release Regina A. Kreisle, M.D., Ph.D. Role of Phosphorylation in the Dynamics of Purdue University Brain Spectrin in Aging Neurons Mohammad A. Pahlavani, Ph.D. Jorge A. Busciglio, Ph.D. Investigation of Age-related Changes in University of Texas Health Science Center at Children’s Hospital, Boston Angiogenesis Using an Intradermal Julie K. Staley, Ph.D. A Human Cortical Culture System as a San Antonio Angiogenesis Assay in Mice University of Miami School of Medicine Does Caloric Restriction and/or Model for Alzheimer’s Disease Characterization of the Galanin Receptor in Dehydroepiandrosterone Therapy Alter the Bruce S. Kristal, Ph.D. the Human Brain Throughout the Lifespan Joseph M. Capasso, Ph.D. Age-related Decline in HSP 70 Expression in University of Texas Health Science Center at and in Dementia New York Medical College Lymphocytes? San Antonio Mechanical Cell Death Contributes to the Oxidant-induced Repression of Henri Tiedge, Ph.D. Development of Heart Failure in the Aged David Roth, Ph.D. Mitochondrial Transcription: Testing the Mount Sinai School of Medicine University of Colorado Predictions of the Free Radical and Free Dendritic Protein Synthesis in the Aging Rat Dean E. Dluzen, Ph.D. Molecular Mechanisms for Altered Radical/Glycation Theories of Aging Brain Northeastern Ohio Universities Adrenergic Responses during Aging: Effects Age-related Changes in Olfactory Bulb of Chronic Dynamic Exercise on Cardiac Annette T. Lee, Ph.D. Danny F. Watson, M.D., Ph.D. Noradrenergic System: Implications of Signal Transduction Picower Institute for Medical Research Wayne State University School of Medicine Neurochemical Correlates of Olfactory Age-related DNA Mutations of the Integrated Cytoskeletal Proteins of the Aging Brain Memory-recognition Processes Alan R. Shuldiner, M.D. 1acI Gene in Transgenic Mice Jacek M. Witkowski, M.D., Ph.D. Johns Hopkins University Nejat K. Egilmez, Ph.D. Duplication Scanning of Chromosome Kathy Magnusson, D.V.M., Ph.D. University of Michigan McClellan Memorial Veterans Affairs Hospital New Subsets of T-cells in Old Mice - 21g22 in Alzheimer’s Disease Colorado State University Identification and Characterization of Genes Age-related Changes in the Function of Differential Expression of P-glycoprotein that Modulate Lifespan in Luis Felipe Sierra, Ph.D. Caenorhabditis Excitatory Amino Acid Receptors Medical College of Pennsylvania elegans Testing the Role of Cysteine Proteinases in Margaret K. McLaughlin, Ph.D. Mona M. Everett, Ph.D. 1991 Grantees the Process of Aging Children’s Hospital Medical Center, Cincinnati University of Texas Health Science Center at Interaction between Age and Ovarian Stephen E. Alway, Ph.D. Ray Thweatt, Ph.D. San Antonio Hormones on Resistance Artery Function TGF-ß Family Proteins and Cultured Bone Ohio State University University of Arkansas for Medical Sciences Effects of Aging on Regulation of Overload- Marrow Stromal Cells from Mature and Characterization of Novel Genes Estela E. Medrano, Ph.D. induced New Muscle Fiber Formation and Aging Rats Overexpressed in Senescent Human University of Cincinnati College of Medicine Myosin Expression Fibroblasts Cellular, Biochemical and Molecular Ronaldo P. Ferraris, Ph.D. Characterization of the Aging Melanocyte from Mariann Blum, Ph.D. University of Medicine & Dentistry of New Wilma Wasco, Ph.D. Human Adult Skin: A Preliminary Approach Mount Sinai School of Medicine Massachusetts General Hospital Jersey The Role of EGF and bFGF Gene Expression Effect of Age on Site Density of Intestinal Analysis and Expression of Human Amyloid Keith C. Meyer, M.D. in the Maintenance and Neurodegeneration D-glucose Transporters Precursor-like Protein 2 (APLP2) Gene University of Wisconsin of Mesostriatal Dopamine Neurons Transcripts in Alzheimer’s Disease and Immunologic Changes in the Aging Human Nestor F. Gonzalez-Cadavid, Ph.D. Normal Brains Lung Patsy M. Brannon, Ph.D. Harbor/University of California, Los Angeles University of Arizona Huachen Wei, Ph.D. Medical Center Dorabeth Parsons, Ph.D. Aging, Malnutrition and Pancreatic Function The Role of Aging in Erectile Dysfunction: University of Alabama, Birmingham University of Colorado Oxidative DNA Damage and Cerebral Aging Assessment of the Nitric Oxide Cascade in Hormonal and Cellular Response to Heavy Edith A. Burns, M.D. the Aged Rat Penis Resistance Exercise in the Elderly Sinai-Samaritan Medical Center David Wilson, Ph.D. The Role of T-cell and Accessory Cell- University of Miami Marcia N. Gordon, Ph.D. derived Cytokines in the Decreased Specific Can Aging and Mortality be Reduced by University of Southern California Humoral Immune Response of Aging Microglial Responses to Injury in Aging Brain Blocking the Function of Particular Genes 11 Late in Life? Sherry Bursztajn, Ph.D. Monte V. Hobbs, Ph.D. Janet S. Sunness, M.D. Timothy L. Denton, Ph.D. Mailman Research Center, Boston Scripps Clinic, La Jolla Johns Hopkins University School of Medicine Andrus Gerontology Center at the University of Expression of Calcium-activated Neutral Subsets of CD4+ T-cells in Aging Mice Retinal Sensitivity Change as a Marker for Southern California Proteases in an Age-related Model of Spinal Developing Subretinal New Vessel Membranes Expression of BDNF in the Aging Brain Cord Degeneration Laura J. Jenski, Ph.D. in Age-related Macular Degeneration Indiana University Henry J. Donahue, Ph.D. Greg D. Cartee, Ph.D. Omega-3 Fatty Acids in Plasma and John P. Walsh, Ph.D. Stony Brook Health Sciences Center, State University of Wisconsin-Madison Mitochondrial Membranes of Aging University of Southern California University of New York Mechanisms of Altered Glucose Metabolism T-lymphocytes Age-dependence of the Electrophysiological Age-related Changes in Bone Cell Signal with Chronic Growth Hormone Treatment in Response to Excitotoxity in the Basal Transduction Mature, Middle-aged and Old Rats Rodrigo O. Kuljis, M.D. Forebrain University of Iowa Kevin Flurkey, Ph.D. Jane Reichert Clements, Ph.D. Cytochemical Substrate of the Visual Christina Wang, M.D. Boston University School of Medicine Texas A & M University Impairment in Aging and in Alzheimer’s Cedars-Sinai Medical Center The Cellular Basis for Age-related Change in Age-related Changes in Excitatory Amino Disease The Effect of Aging on the Role of Insulin Activation of Helper T Lymphocytes Acid Neurotransmission within the Growth Factor I in Testicular Substantia Nigra Anat A. Lev, Ph.D. Steroidogenesis in the Rat Changiz Geula, Ph.D. Massachusetts General Hospital Beth Israel Hospital, Boston Robert A. Colvin, Ph.D. Cloning of Ciliary Neurotrophic Factor and Funmei Yang, Ph.D. Effects of Aging on the Morphometric Ohio University College of Osteopathic Medicine Characterization of its Role in Aging and University of Texas Health Science Center at Parameters of Cholinergic Neurons of the Na/Ca Exchange and Brain Aging Age-related Disorders of the Human San Antonio Nucleus Basalis of Meynert in Man Nervous System Molecular Basis for the Age-modulated Perry L. Colvin, Jr., M.D. Ceruloplasmin Expression in Kidney F. Michael Gloth, III, M.D. Bowman Gray School of Medicine at Wake Alice C. Levine, M.D. Johns Hopkins University School of Medicine Forest University Mount Sinai Medical Center Judith I. Yannariello-Brown, Ph.D. Vitamin D Deficiency in Homebound Elderly Acclimation to Dietary Cholesterol in Macaca In Vitro Studies on the Pathogenesis of University of Texas Medical Branch fascicularis Benign Prostate Hyperplasia Effects of Aging on Circulating Hyaluronate Steven R. Hager, Ph.D. Levels and Liver Endothelial Cell Medical College of Wisconsin Robert E. Corin, Ph.D. Richard J. McCormick, Ph.D. Hyaluronate Receptor Function Cellular Mechanisms of Age-related Insulin College of Staten Island, City University of New University of Wyoming Resistance in Rat Muscle and Adipose Tissue York Myocardial Collagen Gene Expression and Cho-yau Yeung, Ph.D. Cloning of GH-induced Antiproliferative Extracellular Matrix Characteristics of the University of Illinois College of Medicine Seigo Izumo, M.D. Genes during Terminal Differentiation Rat Heart: Effects of Aging and Exercise Transgenic Animal Models of Alzheimer’s Beth Israel Hospital, Boston Training Disease Molecular Mechanisms of Myocardial Isabelle (Reveillaud) Draper, Ph.D. Senescence: Role of Proto-oncogene Linus Pauling Institute, Palo Alto Charles V. Mobbs, Ph.D. Expression Development of Transgenic Animals for Rockefeller University Aging Research: Introduction of Antioxidant A Neuroendocrine Mechanism Potentially 1990 Grantees Li Li Ji, Ph.D. Genes in Drosophila Mediating Effects of Dietary Restriction and University of Illinois Sid P. Bacon, Ph.D. Glucose on Age-correlated Pathologies Aging and Antioxidant Enzymes: Adaptation Catherine E. DuBeau, M.D. Arizona State University to Chronic Exercise Detection of Amplitude Modulation in the Harvard Medical School Douglas C. Powers, M.D. Elderly A Simplified Diagnostic Strategy for Benign Saint Louis University School of Medicine Mirtha Kelijman, M.D. Prostatic Hypertrophy in Elderly Men Age-related Changes in Lymphocyte Adhesion Saint Louis University School of Medicine Bula Bhattacharyya, Ph.D. Spontaneous Secretion of Growth Hormone Janet M. Dubinsky, Ph.D. Mitch O. Rotenberg, Ph.D. University of Iowa in Aging Humans Age-related Alteration of Neuromuscular University of Texas Health Science Center at Medical College of Pennsylvania Transmission: Effect of Halothane San Antonio Isolation of cDNAs Encoding Human, Madeleine A. Kirchberger, Ph.D. Role of Intracellular Calcium Levels in Senescence-specific Anti-proliferative Mount Sinai Medical Center Paula Bickford-Wimer, Ph.D. Trophic Factor-dependent Survival of Central Factors: A Novel Approach Is Increased Phosphoprotein Phosphotase University of Colorado Health Sciences Center Cholinergic Neurons Activity a Possible Factor in Decreased Cerebellar Involvement in Age-related Janet Rubin, M.D. Responsiveness to ß Adrenergic Hormones Impairments in Motor Learning John Fox, Ph.D. Emory University School of Medicine in Senescent Myocarium? Tulane University Medical Center Effects of Time-varying Electric Fields on Gabriel H. Brandeis, M.D. Regulation of Parathyroid Hormone in Aging Bone Resorption and Formation G. Gopal Krishna, M.D. Harvard Medical School Rats Temple University School of Medicine A Simplified Diagnostic Test for Joseph A. Schauerte, Ph.D. Effect of Potassium Depletion on Blood Incontinence in Frail Elderly Men Ruby Ghadially, Ph.D. University of Michigan Pressure in Elderly University of California, San Francisco Role of Charge-transfer in Ligand Binding Judith Campisi, Ph.D. Functional and Structural Alterations in and Chemical Oxidation Robin J. Leach, Ph.D. Boston University School of Medicine Aged Epidermis University of Texas Health Science Center at Cellular Aging and Proto-oncogene Andrew J. Silver, M.D. San Antonio Expression Mark D. Grabiner, Ph.D. Saint Louis University School of Medicine Regulation of the Estrogen Receptor in an The Cleveland Clinic An Animal Model of Age-related Hypodipsia Osteoblast-like Osteosarcoma: A Model for Ming L. Chen, Ph.D. Relationship between Trunk Biomechanics Osteoporosis Saint Louis University School of Medicine and Falling Behavior in the Elderly Thomas M. Skeehan, M.D. Age-related Changes in the Regulation of Penn State Milton S. Hershey Medical Center Ruth Medina, Ph.D. Renal Ca-binding Protein by Vitamin D Brenda Hall, Ph.D. Mechanisms of Anesthetic-induced Harvard Medical School Mount Sinai Medical Center Myocardial Depression in Senescence: In Systems for Degrading Abnormal Proteins Barbara A. Clark, M.D. Study of Frequency of Somatic Mutation in Vitro and Ex Vivo Studies in Brain in Alzheimer’s Disease Harvard Medical School V Gene Encoding Autoantibodies during Mechanisms of Secretion and Aging Dan F. Spandau, Ph.D. Mervyn Monteiro, Ph.D. Pathophysiologic Consequences of Elevated Indiana University School of Medicine University of Maryland Atrial Natriuretic Peptide in the Elderly Marilyn Hartman, Ph.D. Anti-oncogene Expression during Terminal A Biochemical and Immunological Study of University of North Carolina Differentiation and Cellular Senescence Neurofilaments in Aging David C. Dale, M.D. Age Differences in Selective Attention and University of Washington Memory Rama K. Nemani, Ph.D. Hematopoietic Progenitors and Aging: 12 Saint Louis University School of Medicine Proliferative Response to Hematopoietic Decreased Renal Production of Biologically Growth Factors Active Vitamin D with Age Carol J. Phelps, Ph.D. Stephen Baumann, Ph.D. Scott L. Mader, M.D. Roy B. Verdery, M.D., Ph.D. Tulane University Medical Center University of Texas Medical Branch Case Western Reserve University Bowman Gray School of Medicine at Wake Catecholaminergic Neuron Plasticity in the The Use of Magneto-encephalography to Effect of Aging on Adrenergic Physiology in Forest University Aged Rat Brain Detect Mild Alzheimer’s Disease Cultured Vascular Smooth Muscle Cells Role of Lipoproteins in Production of Tumor Necrosis by Monocyte-Macrophage Raymond M. Quock, Ph.D. Xandra O. Breakefield, Ph.D. Jeffrey N. Masters, Ph.D. University of Illinois College of Medicine Eunice Kennedy Shriver Center, Boston University of Southern California Bryant Villeponteau, Ph.D. Opioid Analgesia and Brain Opoid Age-related Regulation of Monamine Glucocorticoids and the Aging Hippocampus University of Michigan Radioligand Binding in Senescent Rats Oxidase Genetic Markers of Aging and Roger B. McDonald, Ph.D. Immortalization Jane F. Reckelhoff, Ph.D. Karen P. Briski, Ph.D. University of California, Davis University of Mississippi Medical Center Washington State University Effect of Age and Gender on the Neural Hoau-yan Wang, Ph.D. Mechanisms of Age-dependent Change in Immunologic and Biologic Potencies of Control of Pancreatic Function Medical College of Pennsylvania Renal Protein Turnover in the Rat Prolactin Hormonal Forms Synthesized by The Effect of Age on Human Protein Kinase C Young and Old Rat Pituitary Glands Michael J. Meldrum, Ph.D. Scott W. Rogers, Ph.D. University of Florida College of Pharmacy Zahra F. Zakeri, Ph.D. Salk Institute for Biological Studies, San Diego Donald M. Caspary, Ph.D. Alterations in Glutamate Release in Aging University of Medicine & Dentistry of New Excitotoxicity in RAT 2 Fibroblasts Stably Southern Illinois University School of Medicine Jersey Expressing a cDNA Encoding a Member of Age-related Changes in a Central Auditory Russell L. Moore, Ph. D. Stress Proteins and Stress Response in the Glutamate Receptor Family Structure: A Key to Presbycusis Penn State Milton S. Hershey Medical Center Aging Tissues Adaptation of Senescent Myocardium to Martin Sarter, Ph.D. William T. Cefalu, M.D. Training Ohio State University Bowman Gray School of Medicine at Wake Disinhibition of Cortical Cholinergic Activity Forest University William C. Orr, Ph.D. 1988 Grantees and Attenuation of Age-related Attentional The Role of the Aging Process on Insulin Southern Methodist University Ina J. Amber, M.D. Impairments Receptor Recycling In Vivo The Effects of Glutathione Peroxidase on Aging in Transgenic Drosophila University of Utah Effects of Age on the Activation and Cytoxic Jacob J. Steinberg, M.D. Terriann Crisp, Ph.D. Effector Mechanisms of Macrophages Albert Einstein College of Medicine Northeastern Ohio Universities Horace M. Perry, M.D. Alteration of DNA Binding Sites and Proteins Age-related Changes in Spinal Opiate- Saint Louis University School of Medicine Rosemarie M. Booze-Aron, Ph.D. in Aging induced Analgesia Involutional Osteoporosis, Osteoblast and Osteoclast Activity University of Kentucky Medical Center Initiation and Maintenance of Neural Growth Bruce R. Troen, M.D. Susan Ettinger, Ph.D. in Aging: Role of NGF University of Michigan Cornell University Medical College John W. Rachow, M.D., Ph.D. Regulation of Expression of Cathepsin L Age-associated Chromosomal Fragility in University of Iowa College of Medicine Connie W. Bales, Ph.D. Human Lymphocytes The Role of Matrix Vesicle Function in Alan Tucker, Ph.D. Herteroptic Ossification Following Hip Duke University Medical Center Vitamin D Metabolism: A Function of Kidney Colorado State University Donna D. Flynn, Ph.D. Arthroplasty Donor Age The Effects of Aging and Exercise on University of Miami School of Medicine Vascular Reactivity in the Isolated Perfused Age-altered M-1 Muscarinic Receptor Function Richard L. Riley, Ph.D. Margaret M. Baumann, M.D. Rat Hindlimb University of Miami School of Medicine Joseph A. Gascho, M.D. Regulation of ß Lineage Immunocyte Harvard Medical School Cellular Mechanisms of Incontinence in the David S. Ucker, Ph.D. Penn State Milton S. Hershey Medical Center Development in Aging Elderly Medical Biology Institute, La Jolla The Effects of Aging on the Venodilatory Susceptibility of T-cells to Activation-driven Response to Nitroglycerine Eugene L. Roberts, Jr., Ph.D. Elizabeth S. Boylan, Ph.D. Cell Death: Aging-associated Changes and University of Miami School of Medicine Queens College, City University of New York Autoimmunity Gabriel Gold, M.D. Increased Vulnerability of Aged Brain to The Control of Metastisis by Dietary Fat in Mount Sinai Medical Center Anoxia Aged Rats Molly S. Weiler, Ph.D. Influence of Age on Basal and Exercise University of Wisconsin School of Pharmacy Stimulated Atrial Natriuretic Hormone Dorrie E. Rosenblatt, M.D., Ph.D. Anne M. Cataldo, Ph.D. Muscarinic Modulation of Neostriatal University of Michigan McLean Hospital Acetylcholine Release during Senescence Reuben Gonzales, Ph.D. Protease Nexin I Binding: A Biochemical Molecular Mechanisms of Neuronal University of Texas Marker for Alzheimer’s Disease? Proteolysis during Normal Aging and Late- William V. Williams, M.D. Effects of Aging on Glutamate Receptor onset Neurodegenerative Disease University of Pennsylvania Function Robert D. Shaw, M.D. Autoimmunity and Aging: Cyrokine Veterans Affairs Medical Center, Northport, NY James R. Connor, Ph.D. Involvement in the Development of Susan Greenspan, M.D. Prolactin Rejuvenation of Aged Murine Pennsylvania State University Rheumatoid Sinovitis Harvard Medical School Mucosal Immunity The Role of Newly Discovered Coenzyme Aluminum Access to the Brain: The Role of the Transferrin Receptor John Ding-e Young, M.D. Ph.D. PQQ in Age-related Dopamine Regulation J. David Sweatt, Ph.D. Rockefeller University Baylor College of Medicine Nazneen Dewji, Ph.D. Molecular Mechanisms of Programmed Cell Sharon K. Inouye, M.D. Cholinergic and Noradrenergic Mechanisms University of California, San Diego School of Death (Apoptosis) Yale University School of Medicine in the Hippocampus: Possible Molecular Acute Confusional State in the Hospitalized Locus for Aging-related Memory Medicine Elderly: Incidence, Risk Factors and Dysfunction Molecular Studies of Disorders of Complications Accelerated Aging 1989 Grantees Mitchell S. Turker, Ph.D. S. Michal Jazwinski, Ph.D. University of Kentucky School of Medicine Peter D. Gorevic, M.D. Kevin J. Anderson, Ph.D. Louisiana State University Medical Center An In Vitro Analysis of a Mammalian State University of New York, Stony Brook University of Florida The ß-Amyloid Gene of Yeast Hibernation Factor Amyloid and Aging: Abnormalities in the Excitotoxicity and NMDA Receptors in the Processing of Autologous Proteins Aged Brain Donald A. Jurivich, D.O. Randall J. Urban, M.D. Northwestern University Medical Center University of Virginia School of Medicine Marilyn Gossman, Ph.D. John Aronson, Ph.D. Signal Transduction during Heat Shock and Sex Steroidal Mechanisms Modulating FSH University of Alabama, Birmingham Wistar Institute Senescence Elevations in Healthy Men Relationship of Strength, Muscle Length, Enhancer Sensitive Cell Lines for Aging Balance, and Gait Characteristics to Falling Studies Frances M. Leslie, Ph.D. in Elderly Women University of California, Irvine Neurotransmitter Correlates of Senescent 13 Memory Decline Ernest R. Greene, Ph.D. Gretchen H. Stein, Ph.D. Margaret A. Griffin, M.D. Joe E. Springer, Ph.D. Lovelace Medical Foundation University of Colorado Pettis Memorial Veterans Affairs Hospital Hahnemann University Age-related Differences in Human Regional Expression of a Senescence-related Gene A T-cell Biomarker of Cellular Aging Transplantation of NGF-rich Tissue Provides Blood Flow during Cellular Aging Trophic Support for Damaged Cholinergic Jerome H. Herman, M.D. Neurons Margaret T. Hessen, M.D. Michael K. Stock, Ph.D. University of Cincinnati College of Medicine Medical College of Pennsylvania Oregon Health & Science University Healing of Osteoarthritic Cartilage by Einar Stefansson, M.D., Ph.D. Role of Lymphokines in Decreased Effect of Prenatal Oxygen Exposure on Nd:YAG Laser Radiation Duke University Medical Center Lymphoproliferative Response of the Elderly Growth, Metabolism, Aging and Longevity Surgical Relocation of the Macula: A Treatment and Relation to Morbidity and Mortality of Drosophila Andrew K.S. Ho, Ph.D. for Age-related Macular Degeneration University of Illinois College of Medicine Martin I. Horowitz, Ph.D. Joyce S. Tenover, M.D., Ph.D. Molecular Mechanisms of Muscarinic Trygve O. Tollefsbol, Ph.D. New York Medical College Harborview Medical Center, Seattle Acetylcholine Receptor in Aging Duke University Medical Center Glycation of Histones in the Aging Brain Effects of Testosterone Replacement in RNA Processing and Enzyme Induction in Elderly Men Anne L. Hoff, Ph.D. Aging Using Cloned cDNA Probes Mark D. Johnson, Ph.D. State University of New York, Stony Brook Medical College of Pennsylvania Nancy G. Weiland, Ph.D. The Effects of Tricyclic Antidepressant Nihal Tumer, Ph.D. Stimulus Response Coupling in the Aging University of Maryland Medication on Cognitive Functioning in the Medical College of Pennsylvania Vasculature NMDAS and GABA Receptors in Aging Aged Age-related Changes in the Effect of Females Circulating Catecholamines on the Cardiac Judith A. Kiritsy-Roy, Ph.D. Laura L. Mays Hoopes, Ph.D. Adrenergic Neuroeffector Junction University of Michigan Occidental College Role of Opioid Peptides & Corticotrophin Decreased DNA Methylation Capacity in Cheryl A. Walters, M.D. Releasing Hormone to Modulate 1987 Grantees Aging Mouse Liver Cornell University Medical College Sympathetic Outflow & Cardiovascular Age-related Antibody Kinetics of Polyvalent Vincent J. Aloyo, Ph.D. Function during Aging Process of Rats Jeffrey N. Joyce, Ph.D. Pneumococcal Vaccine Medical College of Pennsylvania University of Pennsylvania Age-related Alteration of Hypothalamic Daniel A. Kirschner, Ph.D. Neurotransmitter Alterations in Aged Striatum Serotonin Stimulus-secretion Coupling Boston Children’s Hospital ß-Amyloid of Alzheimer’s Disease: Assembly Donald A. Kleinsek, Ph.D. 1986 Grantees Jeffrey Aron, M.D. and Stability Baylor College of Medicine Mount Zion Hospital, San Francisco Gene Expression Studies of Cellular Aging In Gary Aston-Jones, Ph.D. Physiological Determinants of Resting Dalane W. Kitzman, M.D. Vitro New York University Energy Expenditure in the Elderly Physiological Properties of Cholinergic and Duke University Medical Center Age Relationships in Central & Peripheral Melinda A. Lee, M.D. Noradrenergic Cortical Afferent Neurons in Carol A. Barnes, Ph.D. Cardiovascular Function during Rest and Oregon Health and Science University Behaving Primates: Changes with Old Age University of Colorado Exercise in Normal Subjects Regulation of Hematopoiesis by Marrow Effects of Aging on Sensory-motor Stromal Cells: Age-related Changes Cynthia M. Beall, Ph.D. Information Processing Capabilities of Gary Kochersberger, M.D. Case Western Reserve University Mammalian Association Cortex Age and Adaptation to High Altitude Hypoxia Buffalo Veterans Affairs Medical Center Timothy A. McCaffrey, Ph.D. The Metabolic Effects of Calcium Cornell University Medical College Jerry G. Blaivas, M.D. Paul E. Bendheim, M.D. Supplementation in the Elderly Age and Smooth Muscle Proliferation: Columbia University College of Physicians and Potential Influence of PDGF-like Factors New York State Institute for Basic Research Scrapie as a Model for Alzheimer’s Disease: Deborah C. Mash, Ph.D. Surgeons Urodynamics of Aging Purification & Characterization of a Putative University of Miami School of Medicine David G. Morgan, Ph.D. Age-altered Neurotransmitter Receptor University of Southern California Amyloid Precursor Protein Terrence F. Blaschke, M.D. Architectonics Gene Expression in Alzheimer’s Disease Stanford University Medical Center Jesse M. Cedarbaum, M.D. ß Blocker vs. Calcium Channel Blocker: Vincent M. Monnier, M.D. Jay S. Pepose, M.D. Burke Rehabilitation Center, White Plains Relative Incidence of Cognitive Dysfunction Early Signs of Cognitive Impairment in Case Western Reserve University Washington University School of Medicine Structure, Elucidation and Role of a and Depression in Elderly Patients Immunological Studies of Age-related Parkinson’s Disease and Normal Aging Biological Marker for Aging Macular Degeneration John F. Disterhoft, Ph.D. Christopher K. Daniels, Ph.D. Robert W. Rees-Jones, M.D. Northwestern University Medical School K. Murali Krishna Rao, M.D. University of California, San Francisco School Mechanisms of Age-related Memory Deficits Columbia University Duke University Medical Center of Medicine Correction of In Vitro Growth Defects of Mechanisms of Cellular Senescence in Regulation of the Intestinal Immune Linda A. Dokas, Ph.D. Werner’s Syndrome Fibroblasts by Gene Lymphocytes and Neutrophils Response in the Aged Rat Medical College of Ohio Transfer Neurochemical Correlates of Hippocampal Jo Anne Robbins, Ph.D. Ralph Dawson, Jr., Ph.D. Aging Anthony C. Santucci, Ph.D. University of Wisconsin University Florida College of Pharmacy Excitotoxic Amino Acids and Neuronal Loss Bronx Veterans Affairs Medical Center Selected Aspects of Oral-pharyngeal David N. Ernst, Ph.D. An Examination of NGF’s Efficacy in Aged Rats Swallowing in Normal Aging Adults in the Aging Brain Scripps Clinic, San Diego Synthesis and Activity of Interleukin-2 in Jay S. Schneider, Ph.D. Steven H. Robison, Ph.D. Lawrence K. Duffy, Ph.D. Aged Mice Hahnemann University University of Vermont University of Alaska The Effects of Age on Dopamine System Characterization of the DNA Repair Defect in Monoclonal Antibodies to Age-related James W. Gaubatz, Ph.D. Regeneration in a Rodent Model of Familial Alzheimer’s Disease Abnormal Proteins University of South Alabama Parkinsonism DNA Repair of Proto-oncogenes during Aging Miriam Schweber, Ph.D. John Ellis, Ph.D. Thomas Sorger, Ph.D. Boston University School of Medicine University of Vermont Alfred I. Geller, Ph.D. Chromosome 21 DNA Determinations on Selective Regulation of CNS Muscarinic Wistar Institute Massachusetts General Hospital Modulation of Human Vascular Smooth Age-associated Dementias Receptors: Implications for Aging Research Studies on Alzheimer’s Disease and Long Muscle Cell Responses to Monocyte Factors Term Memory Loss in the Hippocampus, In Roger P. Farrar, Ph.D. by n-3 Fatty Acids and DHEA Thomas B. Shea, Ph.D. Vivo, Using HSV-1 Vectors Mailman Research Center, Boston University of Texas Effects of Exercise Upon Age-induced Andrea L. Spiering, Ph.D. Induction of Axonal Atrophy in Cultured Dick Greene, Ph.D. Neuron Cells Deficits in Neuronal Calcium Transport Baylor College of Medicine New Mexico Highlands University Escape from Senescence: The SUSM-1 Cell 14 Aging and Human Regional Blood Flow Line as a Model System Paul G. FitzGerald, Ph.D. Trygve O. Tollefsbol, Ph.D. Kasmierz Malinowski, Ph.D. Richard F. Thompson, Ph.D. University of California, Davis School of Duke University Medical Center Columbia University College of Physicians and Stanford University Medicine Expression of Enzyme Inductive Defects in Surgeons Cerebellar Mechanisms in Age Differences in The Role of Molecular & Cellular Aging in Impaired Immunity of the Aged Age-related Formation of Abnormal Acquisition and Retention of the Classically Ocular Lens Opacification and Cataract Proteins: Investigation of Lens Tissue Conditioned Eyelid Response in Rabbits Larry E. Tune, M.D. Ari Gafni, Ph.D. Johns Hopkins Hospital Charles A. Marotta, M.D., Ph.D. University of Michigan Regional Cerebral Glucose Metabolism & Harvard Medical School Functional Interactions Among Enzymes in Response to Physostigmine in Dementia Molecular Studies on the Aging and 1984 Grantees Aging Muscles Illnesses Alzheimer’s Disease Brain Itamar B. Abrass, M.D. James W. Gaubatz, Ph.D. Steven Waller, Ph.D. Richard A. Miller, M.D., Ph.D. Harborview Medical Center, Seattle Mechanisms of Age-related Changes in ß- University of South Alabama University of South Dakota School of Medicine Boston University School of Medicine DNA Damage during Aging of Postmitotic Nicotinic Cholinergic Binding in Postmortem Age-related Retardation in Stages of T Receptor Cells Brains of Demented Patients Lymphocyte Activation Richard C. Adelman, Ph.D. Ronald H. Goldstein, M.D. Sharon E. Washington, M.D. Catherine Mytilineou, Ph.D. University of Michigan Molecular Heterogeneity of Somatostatin Boston University School of Medicine Ohio State University Hospital Mount Sinai School of Medicine Activation of Aged Vascular Smooth Muscle Intestinal Physiology and Endocrine Tissue Culture Studies on the Aging of during Aging Cells Function with and without the Effect of Central Nervous System Catecholamine Stephen P. Baker, Ph.D. Somatostatin during Post-prandial Neurons University of Florida Laura L. Mays Hoopes, Ph.D. Hypotension in the Elderly Age-related Changes in the Cardiac Occidental College Howard J. Normile, Ph.D. Cholinergic System Methylation of Single Copy Genes during Steven G. Younkin, M.D., Ph.D. Lafayette Clinic, Detroit Aging Case Western Reserve University Relation between Serotonin, Memory & Douglas E. Brash, Ph.D. The Basal Forebrain Cholinergic System in Aging Yale University School of Medicine Thomas E. Johnson, Ph.D. Aging and Alzheimer’s Disease Construction of Chimeras between Long- University of Colorado James J. O’Leary, M.D., Ph.D. and Short-lived Murien Species Molecular Cloning of a Major Gene Elizabeth M. Zelinski, Ph.D. University of Minnesota Specifying Length of Life University of Southern California T-cell Surface Antigen Expression in Aging Man Ellen Buchweitz-Milton, Ph.D. Validation of a Test Assessing Self-percep- Rutgers Medical School Harvey S. Levin, Ph.D. tions of Memory in the Elderly Richard D. Olson, Ph.D. Aged Brain Perfused Capillary Morphometry University of Texas Medical Branch University of Washington School of Medicine Evaluation & Outcome of Senescent Myocardial Function and Aging: Role of & O2 Consumption Forgetfulness Oxygen Free Radicals and the Glutathione Jeffrey A. Chesky, Ph.D. 1985 Grantees Pathway Michael J. Lichtenstein, M.D. Sangamon State University Effects of Aging upon Myocardial Adaptation Vanderbilt University Joshua E. Adler, M.D., Ph.D. Norman W. Pedigo, Jr., Ph.D. to Exercise A Controlled Trial of an Exercise Program to Cornell University Medical College University of Kentucky Improve the Balance of Elderly Women Aged Neurons: Deficits in Neural Plasticity Regulation of Brain Muscarinic Receptor Ursula C. Drager, M.D. at the Molecular Level Subtypes in Aging Victoria N. Luine, Ph.D. Harvard Medical School Neurofilament Abnormalities in Damaged Hunter College, City University of New York Michael J. Belman, M.D. Chandan Prasad, Ph.D. Nerve Cells Endocrine Influences on Aging of the City of Hope National Medical Center Louisiana State University School of Medicine Forebrain Cholinergic System Exercise Intensity and Training Response in Cyclo (His-Pro) and Neuroleptic-induced Andrew P. Goldberg, M.D. the Elderly Animal Model of Tardive Dyskinesia Steven S. Matsuyama, Ph.D. Johns Hopkins University School of Medicine Adiposity, Physical Fitness and Metabolic West Los Angeles Veterans Affairs Medical Michael A. Casey, Ph.D. William J. Rhead, M.D., Ph.D. Function during Aging Center University of Alabama University of Iowa College of Medicine Microtubules & Alzheimer’s Disease Aging in the Auditory System: The Lateral The Molecular Biology of Aging and Lipid Margaret L. Heidrick, Ph.D. Superior Olivary Nucleus Metabolism in Human Fibroblasts John E. Pintar, Ph.D. University of Nebraska Changes with Age in the T-lymphocyte Columbia University College of Physicians and Ian Creese, Ph.D. Mark Rosenthal, M.D. Plasma Membrane Surgeons University of California, San Diego University of New Mexico Growth Factor Gene Expression in Aging Regulation of Dopamine Receptor Turnover Does the Dawn Phenomenon Exist in Victoria P. Knutson, Ph.D. Rats Rates in Aging Normal Elderly Subjects? University of Texas Health Science Center at Martin P. Schweizer, Ph.D. Felix Friedberg, Ph.D. Henry Rothschild, M.D., Ph.D. Houston Effects of Aging on Insulin Receptor and University of Vermont Howard University College of Medicine Louisiana State University Medical Center Studies of Cerebral Metabolism in the Aging Calmodulin mRNA in Various Parts of the Molecular Biology of Aging Glucose Metabolism Rat Using NMR In Vivo Brain in Aging Daniel Rudman, M.D. Douglas L. Schmucker, Ph.D. Harry B. Skinner, M.D., Ph.D. Naomi Kay Fukagawa, M.D., Ph.D. Chicago Medical School University of California, San Francisco School University of California, San Francisco Massachusetts Institute of Technology Renal Effects of Human Growth Hormone of Medicine Finite Element Studies of the Below-knee Glucose and Fatty Acid Metabolism in Therapy in Elderly, Hyposmatotropic Men Effects of Aging on the Liver Mixed Function Prosthesis Aging: Effects of High-carbohydrate, High- Oxidase System fiber Diets and Brief Starvation R.S. Sohal, Ph.D. Nancy W. Stead, M.D. Southern Methodist University R.S. Sohal, Ph.D. Medical College of Georgia Ari Gafni, Ph.D. Relationship between DNA-repair, Southern Methodist University Defective Mononuclear Cell Support of University of Michigan DNA-transcription and Aging Relationship between DNA Strand Breaks Erythropoiesis in Elderly Reversal of Age-related Effects in Muscle and Aging Enzymes Marilyn L. Thoman, Ph.D. H. Lee Sweeney, Ph.D. Scripps Clinic, San Diego William E. Sonntag, Ph.D. University of Texas Raj Kumar, Ph.D. Restoration of Immune Function in the Aged Bowman Gray School of Medicine at Wake Aging-related Alterations in Cardiac University of Illinois with Interleukin 2 Forest University Contractile Protein Expression and Function C-Kinase in Senescence Regulation of Growth Hormone and Protein Synthesis with Age 15 Joseph W. Starnes, Ph.D. Linda J. Kraus, Ph.D. University of Pennsylvania Boston University School of Medicine AFAR Affiliate Research Grant Program Exercise and Diet on Bioenergetics in the Immune and Neuroendocrine Regulatory Aging Rat Interactions in Alzheimer’s Disease and Aging

Linda Taylor, Ph.D. Robert J. Luchi, M.D. Boston University Medical Center Baylor College of Medicine 2005 Grantees Changes in Endothelial Cell Prostacyclin Left Ventricular Function in Patients Synthesis with Age 70 Years or Older AFAR-Ohio AFAR-Upstate New York Erik D. Andrulis, Ph.D. Vera Gorbunova, Ph.D. Marilyn L. Thoman, Ph.D. Kenneth L. Minaker, M.D. Case Western Reserve University University of Rochester Scripps Clinic, San Diego Harvard Medical School Mechanisms of mRNA Turnover during Changes in the Levels of DNA Double- Restoration of Immune Function in the Aged Mechanism of Age-related Loss of Lean Aging strand Break Repair Proteins during Aging with Lymphokines Body Mass and Cellular Senescence AFAR-Southeast George C. Webster, Ph.D. John T. Pinto, Ph.D. Paul Holzheimer, M.D. Florida Institute of Technology Sloan-Kettering Institute Emory University Control of Gene Expression as a Factor in Psychoactive Drugs and Vitamin B2 Investigating the Structural and Functional 2004 Grantees Senescence Metabolism in Aging Neuroanatomy of Late-life Depression AFAR-Southeast Marcus M. Reidenberg, M.D. Anna Moore, Ph.D. Ling Li, D.V.M., Ph.D. Cornell University Medical College Emory University University of Alabama at Birmingham 1983 Grantees Polyamine Accumulation in the Elderly Subcortical Function: Contributions to Statins for Enhancing Learning and Memory Hemispheric Asymmetry Reduction in Older in Normal Aging Cynthia M. Beall, Ph.D. Douglas L. Schmucker, Ph.D Adults Case Western Reserve University University of California, San Francisco School AFAR-Upstate New York Lifelong High Physical Activity Level and the of Medicine Dan Sorescu, M.D. Heinrich Jasper, Ph.D. Aging Process Effects of Aging on Hepatobilliary Functions Emory University University of Rochester Medical Center Regulatory Interactions between JNK and The Role of Nox4 in Cardiac Senescence W. Ted Brown, M.D., Ph.D. David Soifer, Ph.D. Insulin Signaling in the Control of Lifespan New York State Institute for Basic Research New York Institute for Basic Research in Biochemical Studies of Werner Syndrome as Developmental Disabilities a Model of Aging Monoclonal Antibodies for the Study of Alzheimer’s Disease Arthur Cherkin, Ph.D. AFAR/Glenn Breakthroughs David Geffen School of Medicine at the Robert E. Till, Ph.D. University of California, Los Angeles University of North Dakota in Gerontology (BIG) Award Senile Dementia: Combination Drug Therapy Effects of Vasopressin on Age Differences in and Toxicity Memory Two-year awards to provide timely support to pilot research programs that may be of relatively high risk but offer significant promise of yield- Fulton T. Crews, Ph.D. Richard F. Walker, Ph.D. ing transforming discoveries in the fundamental biology of aging. This University of Florida School of Medicine University of Kentucky College of Medicine Interaction of Acetylcholine, Peptide A Pacemaker for Aging in the Female program, sponsored by the Glenn Foundation for Medical Research, Neurotransmitters and Membrane Properties Reproductive System began in 2005. during Aging Diana S. Woodruff-Pak, Ph.D. John Ellis, Ph.D. Stanford University Adam Antebi, Ph.D. Scott D. Pletcher, Ph.D. University of Vermont Brain Correlates of Memory in Old Age Baylor College of Medicine Baylor College of Medicine Central and Peripheral Muscarinic Purification of a lipophilic hormone regulat- Genetic mechanisms of enhanced immune Cholinergic Receptors ing C. elegans diapause and aging function and delayed functional senescence in Drosophila melanogaster William B. Ershler, M.D. 1982 Grantees University of Vermont Thymic Transplantation of Immunescence Edward D. Bird, M.D. Harvard Medical School Caleb E. Finch, Ph.D. Monoamines in CSF and Postmortem Brain AFAR/Pfizer Innovations in Aging University of Southern California in Alzheimer’s Disease Aging and Monoamine Receptors in the Research Award Human Brain Dennis E. Buetow, Ph.D. University of Illinois Phillip K. Fulkerson, M.D. Q-tRNAs and Aging Two-year awards for promising junior faculty scientists who wish to start Ohio State University highly innovative projects focused on the basic biology of aging and its Crystal Analysis of Mineral Deposits in Joseph T. Coyle, M.D. relationship to human disease. Sponsored by Pfizer Inc. This program was Senile Aortic Stenosis Johns Hopkins University School of Medicine Cortical Cholinergic Lesion: Model for active from 2004 to 2005. Paula B. Goldberg, Ph.D. Alzheimer’s Disease Medical College of Pennsylvania Anne Brunet, Ph.D. Psychotropp/Antiarrythmic Drug John M. Lowenstein, Ph.D. 2005 Recipients Stanford University Interactions in Aging Brandeis University Molecular Species of Membrane Role of FOXO Transcription Factors in Katrin Andreasson, M.D. Phospholipids in the Aging Rat Mammalian Longevity Michael Klagsbrun, Ph.D. Johns Hopkins University School of Medicine Children’s Hospital, Boston Function of the PGE2EP Receptors in the Fen-Biao Gao, Ph.D. Role of Cartilage-derived Growth Factor in Peter V. Rabins, M.D. Development of Alzheimer’s Disease J. David Gladstone Institutes at the University Osteoarthritis Johns Hopkins University School of Medicine The Dementia of Depression: CAT Scan of California, San Francisco Steven Artandi, M.D., Ph.D. Correlates Identification of Genetic Pathways That Stanford University Reduce ␣ß Toxicity on Neuronal Structures Activation of Epidermal Stem Cells by Telomerase 16 Adam Gazzaley, M.D., Ph.D. Zhiming Suo, M.D. University of California, Berkeley Midwest Biomedical Research Foundation 2000 Age-related 1999 Cardiovascular Cognitive Aging: Elucidating the Relationship G protein Coupled Receptor Kinase-5 Between Structure Function and Behavior Deficiency, Muscarinic Neurotransmission Neurodegenerative Diseases and Aging Dysfunction and Neurofibrillary Michael S. Grotewiel, Ph.D. Degeneration In vitro Diseases Vincent L. Cryns, M.D. Virginia Commonwealth University Northwestern University Medical School Genetic Dissection of Functional Senescence Azad Bonni, M.D., Ph.D. Role of Mitochondrial Injury in Ischemic Harvard Medical School Myocardial Cell Death and Myocardial Aging in Drosophila 2004 Recipients Neurotrophin Regulation of Amyloid ß-induced Jiyan Ma, Ph.D. Neuronal Degeneration and Cell Death Jay M. Edelberg, M.D., Ph.D. Ohio State University Research Foundation Zheng-yi Chen, Ph.D. Weill Medical College of Cornell University The Role of Ubiquitinated Prion Protein in Massachusetts General Hospital Frank M. LaFerla, Ph.D. Molecular Enhancement of Senescent Hair Cell Regeneration Through Cell Division Neurodegeneration University of California, Irvine Cardiac Chronotropy Molecular Determinants of Presenilins in David K. Simon, M.D., Ph.D. Jay M. Edelberg, M.D., Ph.D. Intracellular Calcium Signaling Pathways Roger J. Hajjar, M.D. Harvard Medical School Weill Medical College of Cornell University Harvard Medical School Cardiac Myocyte Derivation from Aging Mitochondrial DNA Repair and Parkinson’s James Lah, M.D., Ph.D. Restoration of Diastolic Function in the Bone Marrow Cells Disease Emory University Senescent Heart by Gene Transfer Normal and Abnormal Function of Biao Zheng, M.D., Ph.D. Presenilin-1 in Endosomes Domenico Pratico, M.D. Baylor College of Medicine University of Pennsylvania Overcoming Age-associated Immune Glenn C. Telling, Ph.D. In Vivo Isoform-specific Effects of Deficiency by Immune Complex Vaccination University of Kentucky Medical Center Apolipoprotein E on Advanced In Vitro Studies of Human Prions Atherosclerosis

AFAR/Pfizer Research Grant Paul Beeson Career Development One- to two-year award provided support for junior faculty (M.D.’s and Ph.D.’s) who demonstrated a commitment to the field of aging and Awards in Aging Research Program addressed specific areas of research that relate to the care of an aging population. Sponsored by Pfizer Inc. This program was active from 1999 to 2003. (formerly the Paul Beeson Physician Faculty Scholars in Aging Research Program) Three-to five-year awards to sustain and promote the research careers of clinically trained individuals who are pursuing research careers in aging. Laura Anne Vogel, Ph.D. The program is a collaboration between AFAR, the National Institute on 2003 Metabolic Control Illinois State University Generation of Memory Responses by Aged Aging (NIA), The John A. Hartford Foundation, The Atlantic Philanthropies, and Late Life Diseases ß-lymphocytes The Starr Foundation, the NIH Office of Dietary Supplements and the Alliance for Aging Research. The Commonwealth Fund was a previous Yih-Woei C. Fridell, Ph.D. partner in this program. University of Connecticut Health Center Mitochondrial Uncoupling and Aging 2001 Hormones Wendolyn S. Gozansky, M.D., M.P.H. Mary J. Kelley, Ph.D. and Aging 2005 Scholars University of Colorado Health Sciences Center Oregon Health and Science University at Denver Integrin Sensing in Late-onset Glaucoma Anne R. Cappola, M.D. Liana G. Apostolova, M.D. University of Maryland Cortisol Metabolism & Central Adiposity University of California, Los Angeles After Menopause Kevin R. Short, Ph.D. Androgens, Myostatin, and Sarcopenia in Structural MRI Outcome Predictors in MCI Mayo Clinic, Rochester Older Women Age Effects on Mitochondria: From Gene to Leanne Groban, M.D. Malaz A. Boustani, M.D., M.P.H. Wake Forest University School of Medicine Function in Different Tissues Naibedya Chattopadhyay, Ph.D. Indiana University School of Medicine Growth, Angiotensin II, and Cardiac Aging Brigham & Women’s Hospital Enhancing Care for Hospitalized Older Adults Hong Yang, M.D. Anabolic Actions of Ca2+-sensing Receptor with CI Arti Hurria, M.D. Meharry Medical College in Osteoblastic Cells Memorial Sloan-Kettering Cancer Center Age-related Increase in the Sensitivity of Jennifer S. Brach, Ph.D. Can Geriatric Assessment Predict Oncology Endothelial Cells to Oxidized Lipids: The Karyn M. Frick, Ph.D. University of Pittsburgh Outcomes? Role of Reactive Oxygen Species Yale University Gait Variability: Epidemiology, Assessment & Estrogen Replacement in Middle-aged Management Female Mice: Implications for the Treatment Pearl H. Seo, M.D., M.P.H. of Menopausal Women Duke University Medical Center 2002 Immunology Arleen F. Brown, M.D., Ph.D. PPARgamma: Biomarker for Breast Cancer University of California, Los Angeles in Older Women and Aging Joseph M. Zmuda, Ph.D. Neighborhoods and the Management of University of Pittsburgh Chronic Conditions Molecular Epidemiology of Sex Steroid Dellara F. Terry, M.D., M.P.H. Christopher B. Forsyth, Ph.D. Metabolism Genes and Bone Mass in Afro- Boston University School of Medicine Cynthia M. Carlsson, M.D. Centenarian Offspring and Vascular Disease Rush-Presbyterian-St. Luke’s Medical Center Caribbean Men Effect of Aging on Integrin Regulation of University of Wisconsin Medicine School Resistance Effect of Statins on Pathobiology of MMP-13 in Human Chondrocytes Alzheimer’s Disease Lap Ho, Ph.D. Daniel R. Goldstein, M.D. 2004 Scholars Mount Sinai School of Medicine Characterizing the Influence of Immune Yale University Strategies to Enhance Immunity in Aging Sandy Chang, M.D., Ph.D. Inflammatory Activities in the Clinical M.D. Anderson Cancer Center at the University Progression of Alzheimer’s Disease of Texas 17 Dementia Telomere-induced Genomic Instability in Premature Aging Cathleen S. Colon-Emeric, M.D. Kenneth Langa, M.D., Ph.D. Robert A. Marciniak, M.D., Ph.D. Mary Whooley, M.D. Duke University Medical Center University of Michigan University of Texas Health Science Center at University of California School of Medicine, Evidence-based Medicine in the Skilled Long-term Outcomes of Caring for a San Antonio San Francisco Nursing Facility Disabled Spouse Oxidative Stress and Telomere Maintenance: Mechanisms of Association Between In Vitro and In Vivo Studies Depression and Poor Health Outcomes in William Dale, M.D., Ph.D. Sarah H. Lisanby, M.D. Older Patients University of Chicago Columbia University College of Physicians and Laura E. Niklason, M.D., Ph.D. Emotions in Medical Decision-making in Surgeons Duke University School of Medicine Kristine Yaffe, M.D. Older Adults Brain Stimulation and Pharmacological Lifespan Extension of Vascular Cells for University of California School of Medicine, Strategies to Reduce the Cognitive Side Tissue Engineering San Francisco Lee E. Goldstein, M.D., Ph.D. Effects of ECT in Geriatric Depression Determinants of Cognitive Change and its Brigham and Women’s Hospital/Harvard Michael A. Schwarzschild, M.D., Ph.D. Outcomes in African-American and White Medical School Jack M. Parent, M.D. Harvard Medical School Elders Alzheimer’s Disease Beta-amyloid in the University of Michigan Sorting Out Clues to Parkinson’s Disease: Lens Stimulation of Endogenous Neural Stem Caffeine, Postmenopausal Estrogen and Cells to Promote Recovery after Stroke Addiction Cary P. Gross, M.D. 2000 Scholars Yale University Henry L. Paulson, M.D., Ph.D. Jurgen Ünützer, M.D., M.P.H. The Impact of Comorbidity on Older Cancer University of Iowa University of California, Los Angeles Brock Beamer, M.D. Patients RNA interference (RNAi) as Novel Therapy Neuropsychiatric Institute Johns Hopkins University School of Medicine for Age-related Disease Improving Care for Chronic Pain and Late Genetic Variation in PPAR-y and RXRd: John J. Lehman, M.D. Life Depression Effects on Body Composition and Washington University Elizabeth A. Phelan, M.D. Metabolism in Older Adults Mitochondrial Control by PGC-1a in Young University of Washington and Aging Heart Improving Primary Care of Older Adults Gunnar K. Gouras, M.D. 2001 Scholars Weill Medical College of Cornell University Andrew P. Lieberman, M.D., Ph.D. Wendy S. Post, M.D. Neuronal A-beta Accumulation: Aging and University of Michigan Johns Hopkins University School of Medicine Asa Abeliovich, M.D., Ph.D. Oxidative Stress Modifiers of Polyglutamine Toxicity Vascular Properties and Genetics Associated Columbia University College of Physicians & with Longevity in the Amish Surgeons Mary Beth Hamel, M.D., M.P.H. Atul Malhotra, M.D., Ph.D. Molecular Analysis of the Familial Parkinson Harvard Medical School Brigham Women’s Hospital/Harvard Medical Norman Sharpless, M.D. Disease Genes Parkin and Alpha-synuclein Decision-making and Outcomes for Elderly School University of North Carolina at Chapel Hill Patients with Surgical Problems Aging Influence on the Development of The Role of the Tumor Suppressor P16 Katrin Andreasson, M.D. Sleep Apnea ink4a in Mammalian Aging Johns Hopkins University School of Medicine Joshua M. Hare, M.D. Mechanisms of Cyclooxygenase-2-depend- John Hopkins University School of Medicine Marcin Sadowski, M.D., Ph.D. Michael G. Shlipak, M.D., M.P.H. ent Neuronal Injury in Aging and The Role of Nitric Oxide in Aging-related New York University School of Medicine University of California, San Francisco Neurodegenerative Disease Cardiovascular Adaptions Blocking APOE/␣ß Binding as a Novel AD Preventing Heart Failure in Elderly Persons Therapy with Chronic Renal Insufficiency Eric A. Coleman, M.D., M.P.H. Fuki M. Hisama, M.D. University of Colorado Health Sciences Center Yale School of Medicine Catherine A. Sarkisian, M.D., M.S.P.H. Reisa A. Sperling, M.D., M.M.Sc. Reducing Care Fragmentation Across Sites The Molecular Basis of Aging in Werner University of California, Los Angeles School of Brigham & Women’s Hospital/Harvard Medical of Geriatric Care Syndrome Medicine School Intervention to Raise Octogenarians’ Investigating the Neural Underpinnings of Jay M. Edelberg, M.D., Ph.D. Jason H. Karlawish, M.D. Walking Levels Memory Impairment in Aging and Early Weill Medical College of Cornell University University of Pennsylvania School of Medicine Restoration of Senescent Cardiac Alzheimer’s Disease Caregiver and Patient Preferences for the Clemens R. Scherzer, M.D. Angiogenic Activity by Bone Marrow Treatment of Alzheimer’s Disease Brigham & Women’s Hospital/Harvard Medical Transplantation School Jean S. Kutner, M.D., M.S.P.H. Genomic and Genetic Analysis of 2002 Scholars Wesley Ely, M.D., M.P.H., F.C.C.P. University of Colorado Health Sciences Center Parkinson’s Disease Vanderbilt University School of Medicine Symptom Management at the End of Life: David J. Casarett, M.D. The Role of Delirium and Psychoactive Drug Decreasing Distress and Improving Quality Lisa C. Silbert, M.D. University of Pennsylvania School of Medicine Use on Outcomes Following Mechanical of Life Improving Decision-making about End-of- Oregon Health and Science University Ventilation in Older Persons White Matter Change and CNS Process in life Care and Promoting Earlier Referral to Brett Lauring, M.D., Ph.D. the Elderly Hospice Roger J. Hajjar, M.D. Columbia University College of Physicians & Harvard Medical School Surgeons Joe Verghese, M.D. James E. Galvin, M.D. Targeting Signaling Pathways in Aging An In Vitro Assay for Gamma Secretase Albert Einstein College of Medicine Washington University School of Medicine Hearts by Gene Transfer Processing of the Amyloid Precursor Protein Latent Mobility Abnormalities and Disability In Vitro and In Vivo Models of Synucleinopathies James A. Mastrianni, M.D., Ph.D. Frank S. Lee, M.D., Ph.D. University of Chicago School of Medicine University of Pennsylvania School of Medicine Brad Johnson, M.D., Ph.D. Aging and the Misfolded Protein: Prion Protein Kinases and Alzheimer’s Disease 2003 Scholars University of Pennsylvania School of Medicine Disease as a Model for Disaggregating the Functions of the Werner Syndrome Family Aggregate R. Sean Morrison, M.D. Meredith Hawkins, M.D. of Proteins in Telomerase-deficient Mice and Mount Sinai School of Medicine Albert Einstein College of Medicine Yeast Michael C. Naski, M.D., Ph.D. Interventions to Improve Pain Outcomes The Role of Nutrient Excess in Mediating the University of Texas Health Science Center at Insulin Resistance of Aging Albert R. La Spada, M.D., Ph.D. San Antonio Scott A. Small, M.D. University of Washington School of Medicine Matrix Homeostasis and Gene Expression in Columbia University College of Physicians & Michael C. Irizarry, M.D. Development of Therapies for Polyglutamine Aging Cartilage Surgeons Massachusetts General Hospital - Neurodegeneration and Related Disorders Functional Imaging of the Hippocampal East/Harvard Medical School M. Carrington Reid, Ph.D., M.D. Formation in Age-related Memory Decline Beta-secretase and Alzheimer’s Risk with Michael T. Lin, M.D. Yale University School of Medicine Aging Weill Medical College of Cornell University Determining the Impact of Back Pain on Mitochondrial DNA Mutations in Aging and Physical and Social Disability Among Older Alzheimer’s Disease Adults 18 Anne M. Kenny, M.D. Helen Hoenig, M.D., M.P.H. 1999 Scholars University of Connecticut Health Center Duke University Medical Center 1995 Scholars Mechanisms of Bone Loss in Older Men An Investigation of the Physical Costs and Kenneth E. Covinsky, M.D., M.P.H. with Low Testosterone Levels the Quality of Life Benefits of Wheelchairs Ashley I. Bush, M.D., D.P.M., Ph.D. University of California, San Francisco for Older Persons Harvard Medical School Outcomes of Frail Nursing Home-eligible Alison A. Moore, M.D., M.P.H. Zinc Exposure as a Risk Factor for Elders Living in the Community University of California, Los Angeles School of Elan D. Louis, M.D., M.S. Alzheimer’s Disease Medicine Columbia University College of Physicians and Matthew P. Frosch, M.D., Ph.D. Screening for Harmful and Hazardous Surgeons Ted M. Dawson, M.D., Ph.D. Harvard Medical School Drinking in Older Persons Functional Correlates of Essential Tremor Johns Hopkins University School of Medicine Estrogen, Aging and Alzheimer’s Disease Gene Therapy for Neurologic Disorders Mechanisms and Model Systems Thomas T. Perls, M.D., M.P.H. Charles A. Thornton, M.D. Harvard Medical School University of Rochester School of Medicine and David M. Holtzman, M.D. Daniel T. Laskowitz, M.D. The Genetics of Longevity Dentistry Washington University School of Medicine Molecular and Cellular Factors that Play a Duke University Medical Center Pathophysiology of Myotonic Dystrophy, a Apolipoprotein E, Microglial Activation, and Role in Maintaining Neuronal Form and Eric D. Peterson, M.D., M.P.H. Progeroid Syndrome Neurodegenerative Disease Duke University Medical Center Function in the Normal Aging CNS and How Toward a Rational Use of Revascularization They May Be Altered in AD Dale Leitman, M.D., Ph.D. in the Aged University of California, San Francisco 1996 Scholars Edward H. Koo, M.D. Role of Coactivators in Estrogen Repression Scott Turner, M.D., Ph.D. University of California, San Diego School of of Gene Transcription University of Michigan Medical School Christopher M. Callahan, M.D. Medicine The Role of X11& in Amyloid Precursor Indiana University School of Medicine The Mechanism of Amyloid ß-protein (␣ß) Richard Z. Lin, M.D. Protein The Use of Percutaneous Endoscopic Production from the Amyloid Precursor University of Texas Health Science Center at Gastrostomy Among Older Adults in a Protein (APP) in Neurons San Antonio Jeremy D. Walston, M.D. Community Setting The Role of Oxidative Stress in Aging Effects Johns Hopkins University School of Medicine Mark S. Lachs, M.D., M.P.H. on Vascular Smooth Muscle Cell Growth Molecular Etiologies of Age-related Changes Robert W. Doms, M.D., Ph.D. Weill Medicine College of Cornell University and Signal Transduction in Body Composition University of Pennsylvania School of Medicine The Morbidity and Mortality of Elder Abuse Presinilin 1, APP, and Alzheimer’s Disease David R. Lynch, M.D., Ph.D. Raymond Yung, M.D. Frank M. Longo, M.D., Ph.D. University of Pennsylvania University of Michigan Medical School Murali Doraiswamy, M.D. University of California, San Francisco School Excitotoxicity in Neurodegenerative Lymphocyte Homing in Aging Duke University Medical Center of Medicine Disorders: New Understanding from NMDA Apolipoprotein E Type 4 Allele and Cerebral New Strategies for Treating Receptor Subtypes Metabolism in Relatives at Risk for Familial Neurodegenerative Disease Alzheimer’s Disease Edward R. Marcantonio, M.D., S.M. 1997 Scholars Richard A. Marottoli, M.D., M.P.H. Harvard Medical School Harlan M. Krumholz, M.D. Yale University School of Medicine Reducing Delirium in Post-acute Care: Nir Barzilai, M.D. Yale University School of Medicine Development of a Strategy for Identifying An Interventional Trial Albert Einstein College of Medicine Clinical Spectrum, Treatment and Outcome Which Older Drivers are at Risk for Crashes The Effect of Age-dependent Increase in of Elderly Congestive Heart Failure Patients and Moving Violations Mitchell S. Nobler, M.D. Visceral Fat on Insulin Action and Secretion Columbia University College of Physicians & Makau Lee, M.D., Ph.D. Lina M. Obeid, M.D. Surgeons Michele Bellantoni, M.D. University of Mississippi Medical Center Medical University of South Carolina Serotonin and PET Neuroimaging in Normal Johns Hopkins University School of Medicine Studies on Aging, Dietary Restriction and Role of Ceramide in Inducing the Senescent Growth Hormone and Sex Steroid Effects on Aging and Geriatric Depression. Gastric Mucosal Defense Phenotype through Activating a Growth Bone in Older Women Suppressor Pathway and by Inhibiting a Anne Louise Oaklander, M.D., Ph.D. Richard F. Loeser, M.D. Mitogenic Pathway Harvard Medical School James R. Burke, M.D., Ph.D. Rush Medical College Cellular Mechanisms of Chronic Neuropathic Duke University Medical Center Growth Factors and Aging in Cartilage Peter Reaven, M.D. Polyglutamine Proteins as a Model System Pain University of California, San Diego School of for Studying Protein Aggregation and Cell Karen M. Prestwood, M.D. Medicine Death in Aging and Neurodegenerative Thomas A. Rando, M.D., Ph.D. University of Connecticut Health Center The Relationship of Aging and Antioxidant Disease Bone Turnover and the Response to Stanford University School of Medicine Defense Systems to Atherosclerosis Mechanisms of Age-related Muscle Atrophy: Estrogen in Older Caucasian, Hispanic and The Role of Cellular Antioxidant Defenses Mark D’Esposito, M.D. African-American Postmenopausal Women Alan R. Shuldiner, M.D. University of Pennsylvania School of Medicine University of Maryland School of Medicine Functional Neuroimaging Studies of May J. Reed, M.D. Genetics of Diabetes and Obesity in the Working Memory in Normal Human Aging University of Washington School of Medicine Elderly 1998 Scholars Angio-genesis, the Extra-cellular Matrix, and Thomas M. Gill, M.D. Wound Repair in Aging Helene Benveniste, M.D., Ph.D. Yale University School of Medicine Duke University Medical Center Identifying the Events that Precipitate Robert Glenn Smith, M.D., Ph.D. In Vivo Magnetic Resonance Microscopy Functional Dependence Among Community- Baylor College of Medicine and Alzheimer’s Disease: Defining and living Elderly Persons Role of Voltage-gated Calcium Channel Auto Staging the Progression of Alzheimer’s Antibodies in Motoneuron Injury in ALS Pathology in Transgenic Mice Bernard F. Godley, M.D., Ph.D. Overexpressing Beta Amyloid Protein University of Texas Medical Branch The Role of Oxidative Damage and Repair in Laura L. Dugan, M.D. Age-related Macular Degeneration Washington University School of Medicine Mechanisms of Neuroprotection by C60 Todd E. Golde, M.D., Ph.D. Derivatives: Relevance to Oxidative Stress Mayo Clinic Medical School, Jacksonville During Aging Proteolytic Generation of the Amyloid Beta Peptide in Alzheimer’s Disease Terri R. Fried, M.D. Yale University School of Medicine A Longitudinal Study of Terminally Ill Patient’s Preference for Care 19 1993 1990 AFAR/Merck Junior Investigator Award in Investigators Investigators Geriatric Clinical Pharmacology Nabil Andrawis, M.D., Ph.D. Deborah N. Goldner-Robin, M.D. Brown University School of Medicine Vanderbilt University School of Medicine Two-year awards addressed the critical need of developing more physicians Susan Kalish, M.D. Eugenie L. Siegler, M.D. with a command of geriatric clinical pharmacology. Sponsored by the Harvard Medical School University of Pennsylvania School of Medicine Merck Company Foundation. This program was active from 1988 to 2005. 1992 1989 2005 1999 Investigators Investigators Investigators Investigators Dean L. Kellogg, Jr., M.D., Ph.D. Meghan B. Gerety, M.D. Muralindhar Beeram, M.D. James B. Wendt, M.D. University of Texas Health Science Center at University of Texas Health Science Center at University of Texas Health Science Center at University of Illinois at Chicago San Antonio San Antonio San Antonio Fred Kusumoto, M.D. Margaret Winker, M.D. Steven M. Handler, M.D. 1998 University of California, San Francisco University of Chicago Medical Center University of Pittsburgh School of Medicine Investigators 1991 1988 Edward S. Connolly, Jr., M.D. 2004 Columbia University College of Physicians & Investigators Investigators Surgeons Investigators Kayla I. Brodkin, M.D. Gary A. Ford, M.D., M.R.C.P. Richard Lin, M.D. University of Washington School of Medicine Stanford University Medical Center Oumitana Kajkenova, M.D. University of Texas Health Science Center at University of Arkansas for Medical Sciences San Antonio Mark Monane, M.D., M.S. Jerry H. Gurwitz, M.D. Harvard Medical School Harvard Medical School Josh F. Peterson, M.D., M.P.H. Vanderbilt University 1997 Stephen C. Montamat, M.D. University of Washington School of Medicine 2003 Investigators Hoang Duong, M.D. Bruce G. Pollock, M.D., Ph.D. Investigators Columbia University College of Physicians & University of Pittsburgh School of Medicine Surgeons Joseph V. Agostini, M.D. Yale University School of Medicine Tina V. Hartert, M.D. Vanderbilt University Medical Center AFAR/Ellison Medical Foundation Senior Robert G. Riekse, M.D. Seattle Institute for Biomedical & Clinical Postdoctoral Fellows Research Program Research 1996 Investigators Two-year fellowships to encourage and further the careers of postdoctoral 2002 fellows (both M.D.’s and Ph.D.’s) with at least 3 and not more than 5 years Rebecca J. Beyth, M.D. of postdoctoral training, in the fundamental mechanisms of aging. Investigators Case Western Reserve University School of Medicine Cynthia M. Carlsson, M.D. Jeong Hyeon Park, Ph.D. Madison Veterans Affairs Geriatric Research, Daniel T. Kaufer, M.D. 2005 Fellows The Rockefeller University Education and Clinical Center (GRECC) University of Pittsburgh School of Medicine The Roles of p53-interacting Chromatin Johannes H. Bauer, Ph.D. Modifying Complexes in Human Cellular Margaret Pisani, M.D. Brown University Aging Yale University School of Medicine 1995 Mechanism(s) of p53-dependent Lifespan Extension Sarah Sagi, Ph.D. Investigators University of California, San Diego 2001 Malene Hansen, Ph.D. NSAID Modulation of ␥- and ß-secretase Barbara Clark, M.D. University of California, San Francisco Investigators Harvard Medical School Molecular Mechanisms of Lifespan Regulation by the Insulin/IGF-1 Pathways in 2003 Fellows Arti Hurria, M.D. Rahmawati Sih, M.D. C. elegans Memorial Sloan Kettering Cancer Center Saint Louis University School of Medicine Haim Cohen, Ph.D. Supriya Srinivasan, Ph.D. Harvard Medical School Cathy C. Lee, M.D. University of California, San Francisco DNA Break Repair Controlled by SIRT1 via University of Michigan Health Systems 1994 The Role of Serotonergic Signaling in the Deacetylation of Ku70 and Ku80 Energy Homeostasis During Aging Investigators Coleen T. Murphy, Ph.D. 2000 University of California, San Francisco Adalsteinn Gudmundsson, M.D. 2004 Fellows Discovery and Analysis of C. elegans Investigators University of Wisconsin Lifespan Genes Shermali Gunawardena, Ph.D. Helen K. Edelberg, M.D. Fouzia Lagrhissi-Thode, M.D. University of California, San Diego Marc F. Poitras, Ph.D. Mount Sinai School of Medicine University of Pittsburgh School of Medicine Axonal Transport and Neurodegenerative New York University School of Medicine Disease: Is Perturbation in Vesicular Molecular Mechanisms of Tankurase1- 20 Wesley Ely, M.D., M.P.H., F.C.C.P. Transport an Early Neuronal Dysfunction induced Telomere Elongation Vanderbilt University School of Medicine Pathway? AFAR/Glenn Research Grant for AFAR/Merck Research Scholarships in Postdoctoral Fellows Geriatric Pharmacology for Medical and One-year fellowships to encourage and further the careers of postdoc- Pharmacy Students toral fellows (both M.D.’s and Ph.D.’s) with at least 2 and not more than 5 years of postdoctoral training, in the fundamental mechanisms of Two- to three-month awards provided M.D. and Ph.D. students the aging. Sponsored by the Glenn Foundation for Medical Research. This opportunity to undertake a research project in geriatric pharmacology. program was active from 2001 to 2004. Sponsored by the Merck Company Foundation. This program was active from 1998 to 2004.

2004 Fellows Meng-Ping Tu, Ph.D. David C. Johnson Brown University 2004 Scholars University of Florida Yeast-restriction in Juvenile State Extends Paul D. Allen, Ph.D. Geriatric Chronic Pain Management: The Adult Lifespan in Drosophila melanogaster Mary Jo Hessert University of Rochester Effects of Including a Pain Self-assessment University of New England Aging-related Neural Desynchronization in in the Patient’s Medical Chart Assessing Medication Compliance for the Auditory Brainstem 2001 Fellows Elderly Patients in a New York Rural Family Daniel G. Kloda Practice Johannes H. Bauer, Ph.D. University of New England University of Connecticut Health Center Debdutta Bandyopadhay, Ph.D. Role of Dynorphin Peptides in Age-associat- Patricia A. McHazlett The Role of p53 in Lifespan Extension Baylor College of Medicine ed Cognitive Impairment Role of Histone Deacetylation in Texas Tech University Health Sciences Center Divalent Ion Channels as Drug Targets in Robert Dekroon, Ph.D. Melanocytes Senescence Amanda Preston Alzheimer’s Disease Duke University Medical Center Ohio Northern University The Role of Intracellular Pathways Mediated Kathy Barsz, Ph.D. The Role of Excessive MAO-B Activity in the Sarah E. Smith by Lipoproteins in the Regulation of University of Rochester Medical Center Learning Deficits Induced by Aging and University of California, Irvine Apoptosis The Effect of Aging on Physiological Ecstasy Medication Use in Dementia Patients in Correlates of Masked Intensity Judgments Adult Day Health Centers Rugang Zhang, Ph.D. Heather Sturgill Fox Chase Cancer Center Nilufer Ertekin-Taner, M.D. Virginia Commonwealth University Molecular Basis of Cellular Senescence Mayo Clinic, Jacksonville Tissue Factor Polymorphism in Identification of the Novel Late-onset 2003 Scholars Postmenopausal Women Alzheimer’s Disease Gene on Chromosome 2003 Fellows 10 Using Plasma Amyloid Beta Levels as a Kelly Gauthier Kathleen Tschantz Unroe Surrogate Genetic Marker Virginia Commonwealth University Ohio State University Cognitive, Functional and Behavioral Prescribing Medications to Older Drivers: Arjumand Ghazi, Ph.D. Faith Gunning-Dixon, Ph.D. Outcomes of Reducing Anticholinergic Drug Are Physician Resources Adequate? University of California, San Francisco Hospital of the University of Pennsylvania Role of the Somatic Gonad in the Regulation Use in Alzheimer’s Disease Patients Taking The Neural Basis of Age-related Declines in of Aging Cholinesterase Inhibitors Caenorhabditis elegans Episodic Memory 2001 Scholars David W. Killilea, Ph.D. Courtney Hoelting Kimmo J. Hatanpaa, M.D., Ph.D. Texas Tech University Health Sciences Center Angelo A. Baccala Children’s Hospital Oakland Research Institute Johns Hopkins University Cellular Aging Alters Intracellular Iron Characterization of the Agnostic and Johns Hopkins University School of Medicine Catabolism of Alzheimer Amyloid Beta-protein Homeostasis Antagonistic Effects of Selective Estrogen In Vitro RU-486 Gene Switch Regulation of Receptor Modulators (SERMs) and iNOS for the Treatment of Erectile Shunai Jiang, M.D., Ph.D. Estrogen-related Compounds in Septal Dysfunction in Men Taking Nitrate Gawain McColl, Ph.D. Emory University Cholinergic Neurons Containing Drugs and Those Suffering from Buck Institute for Age Research Fas Ligand and Fas in Aging The Role of KU70 in Stress Resistance and the Side Effects of Viagra Olga Kaufman Aging Pankaj Kapahi, Ph.D. University of Southern California Jennifer W. Childress California Institute of Technology Depression and Pain Management of Andrej Podlutsky, Ph.D. Isolation and Characterization of Genes That University of Maryland, Baltimore Disabled Patients Using Effective Age Model Evaluation of Oral Inhaler Technique Pre- University of Texas Health Science Center at Extend Lifespan and Prevent and Post-interventions in Elderly Individuals San Antonio Neurodegeneration Using Drosophila Stress Tolerance and Bat Aging Paul McConnell as a Model System melanogaster West Virginia University School of Medicine Jay Chyung Measurement of Antioxidative Protection in Plamen D. Penev, M.D., Ph.D. Harvard Medical School Mammalian Cells as a Means to Possibly Characterization of the IDE-mediated University of Chicago 2002 Fellows Prevent Neurodegenerative Aging Disorders Degradation of ß in Plasma Membranes Poor Sleep Quality and Testosterone Decline ␣ and in Intracellular Vesicular Compartments Adam H. Gazzaley, M.D., Ph.D. in Older Men Angela A. McMichael of Cells University of California, Berkeley University of Maryland, Baltimore Neural Mechanisms of Memory Function in Claus U. Pietrzik, Ph.D. Improving Diabetes Medication Yana Dadiomova Normal Aging University of California, San Diego Management in Older Adults Role of the LRP in Cytoplasmic Domain in Mount Sinai School of Medicine Medication Management and Health Literacy Dejan Milatovic, Ph.D. APP Processing in Community-dwelling Older Adults Vanderbilt University Cerebral Oxidative Damage in the Models of Leanne Rae Stewart, Ph.D. 2002 Scholars Jennifer L. Johnson Advanced Age, Inflammation and Washington University School of Medicine The Involvement of Mutant PrP Mark Gamber University of Arkansas for Medical Sciences Excitotoxicity Baseline Medication Use in Dementia Accumulation and Apoptosis in University of North Texas Health Science Patients with Disruptive Behaviors Anne Simon, Ph.D. Neurodegeneration in Tg(PG14) Mice Center Hormone Replacement Therapy: California Institute of Technology Reza Kafi Study of Long-lived Mutants of the Investigating Language Barriers University of Michigan Medical Center Ecdysone Receptor Topical Vitamin A (All-trans Retinol) in the 21 AFAR/Merck Treatment of Aged Skin Blake Keller Wei Han Fang Cynthia O. Howell Marc Levsky Commonwealth University/Medical College of University of Iowa University of Florida College of Pharmacy Northwestern University Virginia Phage Display Technique in Drug Screening The Effect of Estrogen Deprivation on Heat SSRI-induced Hyponatremia in the Elderly: Age-related Differences in the Sensitivity to for Alzheimer’s Shock Protein-70 Expression in Rat Skeletal Is it Real Clinical Concern? Ethanol in Humans Muscle David Ganz Carol Mattes Christopher Martin Harvard Medical School Louis J. Kim University of Pittsburgh Medical Center Texas Tech University Health Sciences Center Anticoagulant Use and Monitoring in Elderly Columbia University Human Inducible Nitric Oxide Synthase as Effects of Phytoestrogens on the Survival of Patients with Atrial Fibrillation Active Site-blocked Factor IXa as a Novel Gene Therapy for Erectile Dysfunction Basal Forebrain Cholinergic Neurons In Vitro Treatment for Stroke in a Murine Model of Kathryn L. Harris Focal Cerebral Ischemia Maritess Mauricio Julia K. Nguyen Mercer University Stanford University School of Medicine University of California, San Francisco A Retrospective Study of Adverse Drug David D. Limbrick, M.S. Apolipoprotein E (ApoE) Status and the Is Polypharmacy a Risk Factor for Adverse Reactions Following the Administration of Virginia Commonwealth University Effects of Estrogen Replacement Therapy on Drug Reactions in Geriatric Nursing Home the Influenza, Pneumonia and/or Tetanus- Characterization of Intracellular Calcium Depression and Cognitive Function in Older Residents? diphtheria Vaccines to Geriatric Nursing Kinetics Following Glutamate Exposure in an Women Facility Residents In vitro Model of Stroke and Aging Mai T. Nguyen Jill Scott Western University College of Pharmacy Jiwon W. Kim Tufts University School of Medicine Examining a Role for Diazepam in University of Southern California Reduced Cytochrome P450-3A Activity in Protecting Nerve Cells from Death that is Drug Treatment of Managed Care Patients 1997 Scholars Old Age: An Experimental Model Exposed to Alzheimer Plaque Fragments and Fee-for-Service Patients of Skilled Roni Devlin Nursing Facilities - Comparison of Cost, Selina Shah University of Colorado Health Sciences Center Aimee M. Wright Length of Treatment, Efficacy, and Outcomes Vanderbilt University School of Medicine Computerized Identification of Potential University of Florida Measurements. The Effects of Aging on P-glycoprotein The Relationship of Cognitive-impairing Adverse Drug Events in the Elderly and the Activity in the Central Nervous System. Effect on Physician Response and Drug Medications and Cognitive Ability in Elderly Bismruta Misra Program Utilization Psychiatric Inpatients Massachusetts General Hospital Clinical and Nonclinical Factors of Antihypertensive Polypharmacy

2000 Scholars Andrew G. Solomon Virginia Commonwealth University Jeffrey R. Bishop The Effect of Older Age on Luteinizing University of Iowa AFAR/Glenn Scholarships for Research Hormone (LH) Elimination Neuronal Susceptibility to Environmental Stressors in Parkinson’s Disease: The Role in the Biology of Aging W. Wallace Webster of ␣ß-Synuclein. University of Kansas Medical Center Three-month awards provided M.D. and Ph.D. students the opportunity to Analysis of Loosely-bound Iron in Dena Dubal Alzheimer’s Disease Brain Tissue and conduct a research project in an area of biomedical research in aging, University of Kentucky Correlation with Histopathological Changes under the auspices of a mentor. Sponsored by the Glenn Foundation for Estrogen-mediated Neuroprotection Against Medical Research. This program was active from 1995 to 2004. Stroke Injury in Aging Female Rats: Potential Mechanisms 1998 Scholars Yvonne C. Huckleberry Washington State University Lanning R. Baker Jennifer A. Greenhall Are Explicit Criteria for the Prescribing of Idaho State University 2004 Scholars University of California, San Diego Medications in the Elderly Utilized? An Morphine Metabolites and Gender The Impact of fgf1 and fgf2 on the Assessment of Office-based Physician- Differences in Pain Responses in the Elderly Ezana M. Azene Preservation of Cortical Neurons in the patient Encounters in the United States Johns Hopkins University Aging Mouse Gene Therapy for Peripheral Neuropathic 1990-1997 Irina D. Burd University of Medicine and Dentistry of New Pain Shilpa Iyer Szilard Kiss Jersey University of Georgia Melynda A. Barnes Columbia University College of Physicians & The Importance of Neuron-Astrocyte Klstn-M1: A Novel Yeast Model System to Interactions in Adult Basal Forebrain Mount Sinai School of Medicine Study Telomere Capping Defects and Surgeons Immunohistochemical Analysis of Spinal sRAGE Inhibition of the Post-ischemic Recombinational Telomere Elongation Cords from Disulfiram-Treated G86R Pro-inflammatory Axis: A Novel Treatment Jersey Chen Superoxide Dismutase-1 Transgenic Mice for Stroke Yale University School of Medicine William W. Ja ß-blocker Therapy for the Treatment of California Institute of Technology Ala Berdichevsky Sarah Middleton Acute Myocardial Infarction in Elderly Characterization of Methuselah, a Drosophila Medicare Beneficiaries with Diabetes Massachusetts Institute of Technology G Protein-coupled Receptor Associated with Brown University Identification of Molecular Targets of sir-2.1 Nitrate Use in Very Frail Elderly with Longevity Gene, which Promotes Extension of Coronary Heart Disease James A. Edwards, Ph.D. Virginia Commonwealth University Lifespan of the Nematode Caenorhabditis Youngmok Charles Jang Melissa Wellons Analysis of Plasma Levels of Scopolamine in elegans University of Florida, Gainesville Duke University Healthy Elderly Volunteers Long-term Caloric Restriction (CR) as a HIV Infection: Treatments and Outcomes in Eric Hau-Yun Chang Strategy to Prevent Sarcoplasmic Reticulum Older and Younger Patients Kevin L. Ferguson New York University (SR) Stress Induced Cardiomyocytes Stanford University Receptor Dysfunction in Double Knock-in Apoptosis In Vivo The Effects of Metformin on the APP+PS1 Mice 1999 Scholars Development of Visceral Obesity and Insulin Jennifer Q. Kwong Resistance in Fat-fed Rats Robi Goswami Weill Medical College of Cornell University Patricia M. Engle Duke University Modulation of Mitochondrial Homeostasis Purdue University Rahul Garg Regulation of the Platelet-derived Growth by Bcl-2 in Cells with Mitochondrial DNA Predictors of Serum Anticonvulsant Duke University Factor Receptor-ß by G Protein-coupled Mutations Concentrations in Older Adults and Related RhoA and its Role in the Mechanism of Receptor Kinase-2 Treatment Outcomes Action of Common Glaucoma Drugs 22 Janelle Lauer-Fields Lisa J. Whitson Matthew R. Hosler Jason D. Shepherd Florida Atlantic University University of Texas Health Science Center at University of Medicine and Dentistry of New Johns Hopkins University Engineering and Expression of ADMTS-4 San Antonio Jersey The Involvement of the Immediate Early and ADMTS-5, Proteolytic Enzymes Monomerization and Amyloid Formation of The Role of Oxidation in the TGF- ß Cataract Gene ARC in Endocytosis of Presenilin1 and Involved in Osteoarthritis Progression FALS-Associated Cu-Zn Superoxide Model APP Processing: Implications for Dismutase Mutants Alzheimer’s Disease Maria Lehtinen James G. Jackson Harvard University Brice J. Williams University of Texas Health Science Center at Tiffany E. Shubert Characterization of the Role of MST1 in Medical University of South Carolina San Antonio University of North Carolina, Chapel Hill Oxidative Stress and Aging in Caenorhabditis Altered Neurotrophin Release in Age-related Role of the Novel Transcription Factor Effects of Exercise on Angiogenesis in the elegans Dementia MRG15 in Cell Proliferation and Senescence Hippocampus of Mice Escape Jacqueline Maffucci Brian Silvia University of Texas Hanyu (Maggie) Liang University of Connecticut Hypothalamic Mechanisms for Reproductive 2003 Scholars University of Texas Health Science Center at Targeted Expression of Putative Drosophila Senescence in Aging Female Rats: Roles of San Antonio Uncoupling Protein and its Effect on Scott B. Berger NMDA Receptors and GnRH Neurons Characterization of Transgenic Mice Longevity University of Michigan Overexpressing Thioredoxin2 (Trx2) The Use of Glycosidases as a Means of Patrick McLaughlin Wook Song Correcting Age-dependent Deficiencies of T- University of Washington Janelle Mallett Texas A&M University cell Function Proteomic Analysis of Proteins Related to University of Connecticut Effect of Exercise Training on Age-induced Inflammation in Parkinson’s Disease Effect of Parathyroid Hormone on Upregulation of the iNOS Signaling Pathway Jennifer Capla Osteoblast Proliferation and Apoptosis in in Skeletal Muscle New York University Kathryn A. Moynihan Fgf2 Knockout Mice Investigating the Role of Adult Vascular Washington University Liou Sun Stem Cells in the Pathogenesis of Age-relat- Deacetylation of the Forkhead Transcription Julien Muffat Southern Illinois University ed Disease Factor FOX01 by Mammalian Sir2a California Institute of Technology The Effect of Dwarfism and Caloric Negatively Regulates Insulin Gene Characterization of the Drosophila Restriction on Synaptophysin Expression in Marci L. Chew Expression in Pancreatic ß Cells Apolipoprotein D Homolog as a Novel Gene the Mouse Hippocampus University of Pittsburgh Influencing Lifespan and Stress Resistance Serum Anticholinergicity at Specific Xuan V. Nguyen Susan E. Swanberg, J.D. Muscarinic Receptor Subtypes University of Kentucky Tung Hoang Ngo, Ph.D. University of California, Davis Age-dependent Alterations in Dopamine and Western University College of Medicine Avian Cells In Vitro: A Model System for the Daniel J. Durand the Nigrostriatal System in Prodynophin Effect of Dietary Fat on Androgen-independ- Study of Telomere Length Regulation and Johns Hopkins University Knockout Mice ent Prostate Tumor Growth in Scid Mice Replicative Senescence Myocardial Regeneration by Bone-marrow Derived Stem Cells in Old versus Young Mohammed Zeeshan Ozair Anirban Paul Wistar Rats Aga Khan University Howard University Analysis of Neural Stem Cell Migration Novel Regulators of Manganese Superoxide 2002 Scholars Andrew A. Grimm Towards Brain Tumors by In Vivo Phage Dismutase Gene Transcription in Drosophila Washington University Trinity J. Bivalacqua Display The Functional Relationship Between an Richard J. Perrin Tulane University School of Medicine NAD Biosynthesis Enzyme and the NAD- Role of Superoxide in the Pathophysiology Annalise Paaby University of Illinois at Urbana-Champaign Dependent Deacetylase, SIR2, in Mammals of Age-related Erectile Dysfunction: University of Pennsylvania Analysis of Polyunsaturated Fatty Acid- Selection and Gene Regulation of induced Modification of Alpha-synuclein, a Influence of In Vivo Gene Transfer of Mary A. Hancock Senescence in Natural Populations of Protein Involved in Neurodegenerative Disease Superoxide Dismutase University of Utah Drosophila Comparison of the Levels of Oxidative Deepa Pikle Jinsook Chang Damage Among European Mitochondrial Carlos J. Pantoja University of Maryland University of Texas Health Science Center at Haplogroups Using Phylogenetic Analysis University of California, San Francisco Premature Aging: A ’Defective’ Helicase- San Antonio The Involvement of DAF-16 and HSF-1 in topoisomerase Interaction in DNA Profiling of Mitochondrial Proteins by 2D Jaime M. Hatcher the Regulation of Small Heat Shock Protein Metabolism Gel Electrophoresis in Wild Type and Emory University Genes Heterozygous MnSOD Mice with Age Effects of Chronic Dieldrin Exposure to Amy Pooler Organotypic Slice Cultures of Rat Striatum Julie K. Plowden Massachusetts Institute of Technology Abbie C. Connoy and Nigra Emory University Investigating Age-Related Memory Wake Forest University Effects of Aging on the Kinetics and Impairment: The Role of Cholesterol in Aging and the Regulation of the Interleukin- Kerry L. Hildreth Strength of T-cell Antigen Presenting Cell Synaptic Protein Expression and Membrane 1-Receptor-associated Kinase in Murine Duke University Interactions Formation in the Hippocampus Splenocytes Molecular Mechanisms for Regulation of the Platelet-Derived Growth Factor Receptor Adolfo Sanchez-Blanco Davis C. Ryman Danielle S. Day Beta by Serine Phosphorylation University of Connecticut Health Center Case Western Reserve University University of Colorado Health Science Center UCP5 Deficiency Mimics Caloric Restriction A Genome Scan for Quantitative Trait Loci Effects of Age-related Decline in Sex Renee Ho in Controlling Beta-amyloid Production and Hormones on Resting Energy Expenditure Drosophila melanogaster University of Southern Alabama Deposition in a Transgenic Mouse Model of Enhancing Mitochondrial DNA Repair of Cheryl (Jansen) Ethen Kim Sciarretta Alzheimer’s Disease Oxidative Damage as a Strategy to Delay the University of Chicago University of Minnesota Effect of Aging in Neurons Proteome Analysis of Retinal Proteins Modeling an Intermediate of Beta-amyloid Megha Satyanarayana Fibril Formation University of Texas Southwest Medical Center Steven Hobbs Raina T. Gay A Rapid Fluorescence-based Screen for University of Colorado Tufts University Kun-Chih Kelvin Tsai Long Lived Mutants The Role of Estrogen in Cortisol Induced C. elegans The Effect of Vitamin E on Secondary Harvard University Beta-amyloid Production and Toxicity Bacterial Infection Following Influenza Heterotypic Interactions Between Stress- Ganesh Shankar Infection in Old Mice induced Prematurely Senescent Stroma and Harvard University Troy A. Hornberger Neighboring Epithelial Cells in Aging and Effects of Apolipoprotein E and a1-antichy- University of Illinois, Chicago William Y. Go Cancer motrypsin on In Vivo Production and Regulation of Protein Synthesis Through University of California, San Diego Stabilization of Natural Amyloid Beta-protein Stretch Induced Signaling Events in Aging Elucidating the Function of NFAT5: Possible Oligomers Skeletal Muscle Cell Cycle Modulator in Response to 23 Oxidative Stress, UV/Ionizing Radiation and Hypertonicity Mark F. Haussmann Rose M. Reynolds Lynn Chien Alex Shpilman Iowa State University University of Illinois at Urbana-Champaign Duke University Finch University of the Health How do Long-lived Organisms Delay The Contribution of Population Tumor Necrosis Factor Receptor Subtype- Sciences/Chicago Medical School Senescence - Development of Appropriate Heterogeneity to Mortality Plateaus specific Signaling in Vascular Smooth Impact of the SAPK-1 Pathway on the Age- Models and Techniques Muscle Cells related Impairment of Adipogenesis Ritu Saini Jason Hinman New York University School of Medicine Krishnan M. Dhandapani Faisal Siddiqui Boston University School of Medicine Gene Regulation by Interleukin-8 in Cultured Medical College of Georgia State University of New York, Syracuse The Characterization of Nodal Abnormalities Keratinocytes Mechanisms of Neuroprotection by Numerical Densities of Myonuclei and Satellite in the Aging Brain Estrogen and SERMs Cells in Muscle Fiber Tin the Aging Human Scott Salsman Lateral Cricoarytenoid Muscle: An Cheng Huang Oklahoma Medical Research Foundation Ibtissam Echchgadda Immunohistochemical and Stereological Study Washington University School of Medicine Effect of Active Site Oxidation on the PTEN University of Texas Health Science Center at using Confocal Laser Scanning Microscopy Identification of Genes Involved in Tumor Suppressor San Antonio Caenorhabditis elegans Aging Aging and DHEA-sulfotransferase in Bethany Slater Sarah Speranza Cholesterol and Bile Acid Homeostasis Mount Sinai School of Medicine Kara Johnson University of New England College of Medicine Alpha MSH and Aging Loyola University Medical Center Development of Neurosteroids as Cognitive Mark R. Gavin Effect of Age on ß-lymphopoiesis and the Enhancers Washington University Christine C. Spencer Maintenance of the Mature ß Cell Understanding the Mechanism of S Phase University of Georgia Compartment Raymond W. Thompson Arrest by the Retinoblastoma Tumor The Role of Gene-gene Interactions in Aging University of South Carolina Suppressor Protein Nathan K. LeBrasseur Effect of Aging On Inflammation During Michael Sugarman Boston University Skeletal Muscle Regeneration Following Kristen J. Homes University of California, Irvine Neuregulin/ErbB Signaling in Skeletal Functional Overload Induced Injury Washington University Can Inclusion Body Myositis Be Treated with Muscle: Aging & Atrophy Elucidation of Components of the B3 a Beta Amyloid Vaccine? Maria L. Urso Integrin that are Essential for Bone Sandy Li University of Massachusetts Resorption: A Search for Anti-osteoporosis Junko Takeshita University of Michigan Muscle Function, Disuse and Antioxidants in Therapeutic Targets Washington University Expression Analysis of Type II IP3 Receptor Older Adults Oxidative Damage of DNA: Mechanisms for in Aging Retina Andrew C. Hsieh Carcinogenesis Laura Volpicelli-Daley Albert Einstein College of Medicine Lina Li Emory University The Role of a Novel Forkhead Target Gene in Doris M. Tham University of Alabama at Birmingham The Effects of Chronic Cholinergic Regulating Cellular Senescence University of California, Davis Age-related Thymic Involution in IL-12B Stimulation on Muscarinic Acetylcholine Actions of Peroxisome Proliferator-activated Knockout Mice Receptor Intracellular Trafficking and Carianne Judge Receptor on Diabetic Vasculopathy Expression University of Maryland Paul R. Lockman Investigating the Role RNase-L Plays in Isaiah Turnbull Texas Tech University Health Science Center Min Zhu Senescence Washington University Targeted Brain Delivery of Novel University of Rochester Effect of Aging on the Heat Shock Response Nanoparticles via the Blood-brain Barrier Transcription Modulation by the C-terminal Eleanor A. Knopp and Subsequent Sepsis Survival Choline Transporter Fragment of Amyloid Precursor Protein in Yale University Neurodegeneration The Effect of Aging on the Skeletal Response Christian Von Hehn Carrie Lyons to Intermittent Treatment with PTH Christian-Albrechts-Universitaet, Kiel Queen’s University Brian M. Zid The Role of Kv3.1 and its Regulation in Age- The Impact of Mitochondrial Ultrastructure California Institute of Technology Amy C. Lee related Hearing Loss on Cellular Physiology Investigating the Role of Fatty Acid Amide Massachusetts Institute of Technology Hydrolase in Aging Using Drosophila Age-associated Changes in the Jill M. Weimer Deanna Marchionini melanogaster Inflammatory and Proliferative Response to University of Rochester Rush-Presbyterian-St. Luke’s Medical Center Vascular Injury A Transgenic Animal Model for the Disruption Melatonin Treatment for Optimal Graft of Lysosome/Endosome Function: A Survival in an Aged Rat Model of Patrick McHugh Commonality in Neurodegenerative Diseases Parkinson’s Disease 2001 Scholars University of Louisville Neutrophil (PMN) Senescence: Can PMNs Yama Akbari C. David Mintz Become Too Old to Kill? Mount Sinai School of Medicine University of California, Irvine 2000 Scholars Investigating the Role of Presenilin-1 at the Primary Mechanism Underlying Presenilin Timothy E. Meyer Eric D. Agdeppa Synapse Mutations: Calcium Dyshomesostasis or Washington University University of California, Los Angeles Beta-Amyloid Formation? The Effects of 3-month DHEA Supplementation Biological Probes for Beta-amyloid Plaques Jacqueline E. Payton in Older Adults on Vascular Reactivity in Alzheimer’s Disease: In Vitro Analysis of University of Illinois at Urbana-Champaign Daniela-Annenelie Bota Beta-amyloid-binding Characteristics of Functional Analysis of the University of Southern California Gail C. O’Kane Regulation of Lon Protease Activity with DDNP Analogs Neurodegenerative Disease-related Protein, Massachusetts Institute of Technology Alpha-Synuclein Aging and Level of Oxidative Stress Exploring the Relation Between Set Shifting Rania Al-Shami and Memory Retrieval Mark Rapoport David Badre University of Delaware Relative Levels of OPN-1 and OPN-2 Change Northwestern University Medical School Massachusetts Institute of Technology Thomas J. Scharshmidt Neurobiology of Cognitive Aging: Human During Aging Dynamic State of Mind: Does a More Plastic Northeastern Ohio University College of Prefrontal Cortex and Memory in Normal Cytoskeleton Prevent ß-Induced Medicine ␣ Xinlian Chen Neurogeneration in Hippocampal Neurons? Aging Analysis of Type IIA and IIB Splice Variants University of Texas Health Science Center at of Procollagen in Osteoarthritis Utilizing Kevin J. Bitterman San Antonio Catherine Rehder Laser Capture Microdissection The Response of Mice that Overexpress Virginia Commonwealth University Harvard Medical School A Genetic Screen for Factors That Extend Catalase and Cu/Zn-SOD to Oxidative Stress The Role of Chromosome Specific Telomere Rodney E. Shackelford Lifespan Through Caloric Restriction Pathway Length in Age-related Somatic Cell Des Moines University of Osteopathic Jay Chyung Aneuploidy Medicine Todd A. Cannon Harvard University Ataxia-telangiectasia, Gene Therapy, and the University of Washington Characterizing the Effects of a Mucosal Cellular Aging Process 24 Involvement of WRN Protein in Vaccine for Alzheimer’s Disease Atherosclerogenesis Richard D’Alonzo Jody L. Short Andrew Doan James F. Mele Saint Louis University Western University of Health Sciences Johns Hopkins University The University of Texas Health Science Center Physical Interaction Between Osteoblastic Effects of Human Apolipoprotein E Isoforms Identification and Characterization of at San Antonio Transcription Factors on Olfactory Nerve Plasticity in Mice Interacting Proteins That Modify the Cell The Development of a Transgenic Model to Biology and Neurodegenerative Properties Study the Role of Manganese Superoxide Rajesh Dash Jennifer E. Stine of Presenilin 1, an Alzheimer’s Disease- Dismutase in Oxidative Stress University of Cincinnati University of Texas Health Science Center at linked Protein Phospholamban Phosphorylation as a San Antonio David Merrill Compensatory Mechanism of the Structural Study of FALS-associated Cu-Zn Shawn P. Gallagher University of California San Diego Endangered Myocardium Superoxide Dismutase Mutants University of Delaware Neurodegeneration of the Hippocampal Detecting Early Glaucomatous Visual Field Formation with Aging and Treatment with Allison W. Dobson David A. Sun Loss with Neural Networks Neurotrophic Factors University of South Alabama Medical College of Virginia/Virginia Enhancing mtDNA Repair in Down’s and Commonwealth University Joseph P. Gaut Daniel W. Mudrick Cockayne’s Syndromes Molecular Basis for Stroke Induced Epilepsy Washington University Johns Hopkins University A Myeloperoxidase-Dependent Pathway of Effects of Age on NOS2 Induction and Delia Garigan Leslie P. Tao Oxidative Damage in 1-Mehyl-4-Phenyl- Response to ß-Adrenergic Stimulation in University of California, San Francisco University of California, Los Angeles 1,2,3,6-Tetrahydropyridine-induced LPS and y-INF Exposed Rat Hearts Mapping and Characterization of Novel A Progesterone-dependent Mechanism to Parkinson’s Disease Lifespan Mutations in C. elegans Delay Reproductive Aging Anavelys Ortiz-Suarez Bradley S. Henson University of Michigan David Gordon Robert T. Turner III University of Michigan Characterization of Expanded T-cell Clones University of Chicago Oklahoma University Impact of Parotid-sparing Radiation on in Old Mice Investigation of the Structure of Beta Substrate Specificity of ß-Secretase: Xerostomia and Quality of Life in Head and Amyloid Fibrils Towards Design of Inhibitor Drugs Neck Cancer Patients James P. Passinault Loyola University Medical Center Elise Grenier Baiping Wang Kailiang Jia Angiogenesis and Aging Northwestern University University of Washington University of Missouri at Columbia Regional Differences of Astrocytes in the In Vivo Analysis of the Role of FE65 in Genetic Study of daf-9, A Modulator of Life Nicholas K. Priest Development or Acceleration of Alzheimer’s Alzheimer’s Disease Span in C. elegans University of Georgia Disease The Maternal Effects of Stress Resistance Fei-Shiuann Clarissa Yang Elizabeth Kensinger and Senescence Andreana P. Haley McGill University Massachusetts Institute of Technology University of Virginia Role of Telomere-associated Senescence in Uncovering the Relation Between Short- Eric S. Rawson A Magnetic Resonance Spectroscopic Wound Healing term Memory and Long-term Memory University of Massachusetts Examination of Hippocampal Volume and N- Creatine Loading in Elderly Men acetyl-aspartate Levels in Healthy Aging Elaine Khatod 1999 Scholars Wake Forest University Haifeng Song Jeffrey P. Henderson The Effects of Age and Exogenous Estrogen University of Maryland, Baltimore Washington University Altered Responses of Aged ß Cells to CD40 Erin K. Baehr on the Synaptic Density of Layer II Prefrontal Halogenation of DNA by the Myeloperoxidase Stimulation Northwestern University Cortex: Does Estrogen Replacement Increase System of Activated Phagocytes: Implications Low-intensity Exercise at Night to Phase- Synaptic Density in this Cognition-associated for Carcinogenesis at Sites of Inflammation Veena Viswanath delay Circadian Rhythms of Older Adults Region of the Old OVX Female Brown Noway X Fischer 344 Rat? University of Southern California Role of Apoptosis in Age-related Vicki Kule Jennifer Berkeley Neurodegenerative Disorders: Caspases and University of Michigan Emory University David W. Killilea Characteristics of Disulfide Intermediate in Their Inhibition as a Potential Therapeutic Muscarinic Regulation of Amyloid Precursor University of South Alabama the Aging of Phosphoglycerate Kinase Intervention Protein Metabolism Physiological Oxidant Generators Alter Genomic Integrity Justine Levin Erik D. Bernstein Theodor A. Zainal Rockefeller University Allegheny University of the Health Sciences Daniel E. Kolker University of Wisconsin Estrogen Effect in a Mouse Model of Histologic Quantitation of Age-dependent RAGE, Aging and Peripheral Nerve Northwestern University Alzheimer Disease Oxidative Damage in Rhesus Monkey Regeneration Circadian Gene Expression in Young and Old Hamsters Skeletal Muscle: Effects of Caloric Restriction Stephen S. Lin Wende R. Buras Washington University Boston University School of Medicine Joseph E. Labrie III Snflp Kinase and Aging in S. Cerevisiae The Role of Threonine Phosphorylation in University of Massachusetts 1998 Scholars EGFR Dysfunction with Aging Is U(D)J Recombinase Activity Decreased in J. Andy Mengshol Aged Mice? Dartmouth University Medical School Stuart K. Amateau Manu Chakravarty IL-1 Regulation of Collagenase-3 in University of Maryland Baltimore University of Texas Medical School at Houston James K. Leung Osteoarthritis Estrogen Modulation of Glutamate Proliferative Capacity of Skeletal Muscle Baylor College of Medicine Neurotransmission in the Aging Brain Satellite Cells with Aging Characterizing the MORF4-Related Gene on Renee Miller Chromosome X (MRGX) University of Rochester Peter J. Bayley Judy Y. Chen Gene Expression Profiling in Parkinson’s University of California, San Diego Meharry Medical College Janet A. Martin Disease Serial Position Effects In Rats’ Spatial Memory A Clinical and Molecular Genetic Analysis of University of California, Irvine Early-onset Parkinson’s Disease in an Asian Astrocyte Degeneration and Vascular Kevin Monahan Louis K. Chang American Family Changes in Frontotemporal Dementia University of Colorado Washington University School of Medicine Do Reductions in Carotid Arterial Compliance Isoform-specific Effects of ApoE on Beta- Frank A. Dinenno Ryan A. McTaggart Modulate the Age-related Decline in Arterial amyloid Deposition and Inflammation In Vivo University of Colorado at Boulder Columbia University Baroreflex Function in Sedentary and Femoral Artery Intima-media Thickness: Amyloid-ß and ABAD: A Convergence of Isaac S. Cheng Regularly Exercising Humans? Effects of Aging and Habitual Physical Activity Alzheimer’s Disease and Stroke Tufts University Identification and Characterization of Bhagavathi Ramamurthy Caspase(s) Responsible for the Alternative Penn State University Endoproteolysis of Presenilins During The Effect of Glycation of Myosin on the In 25 Vitro Motility of Actin with Respect to Aging Neuronal Apoptosis Christen M. Cullen Kevin M. Owen Michael Dobryansky Jocelyn Peccei Massachusetts Institute of Technology Loyola University Medical Center New York University School of Medicine University of California, Los Angeles Hemodynamics in Aging and Alzheimer’s The Kinetics of ß-Lymphocyte Production in Angiogenesis and Prognosis of Colorectal Heritability in the Age of Menopause Disease: An fMRI Study Aged Animals Cancer Mark Snow Limor Deutsch Marc D. Paradis Kimberley Ekis University of Southern California Boston University Massachusetts Institute of Technology University of Michigan What is the Actual Relationship Between Gene Transfer in the Aging Myocardial Cell Presenilins 1 and 2: Effects of Correlated Patterns of Epstein-Barr Virus daf-12 and daf-2 in Caenorhabditis elegans Pharmacologic Stimulation of Reactivation in Elderly Humans Adult Longevity? Christopher DeVry Neurotransmitter Receptors Coupled to University of California, Los Angeles Phospholipase C, Phospholipase A2, or Sara Evans Maria Tresini Protein Repair in the Biology of Aging Adenylyl Cyclase Activity on their Cleavage, Baylor College of Medicine Allegheny University of the Health Sciences Transcription and Translation Analysis of the Role of the Human Homolog Defect in the ras/MEK/MAP Kinase Signal Dena Dubal of an Est2 Interacting Protein in Human Transduction Pathway in Senescent Human University of Kentucky Echo V. Rowe Telomere Biology Cells Neuroprotective Effects of Estrogen in Aging University of Washington Complementation of 4NQO Sensitivity in Jonathan Fisher Jonathan Wanagat Melissa Gill Sgs1 Mutant Strains of S. cerevisiae by the Washington University School of Medicine University of Wisconsin-Madison Brown University Human Werner Syndrome Protein Effects of Ovariectomy and Estrogen Mitochondrial Abnormalities in the Effect of D1 Receptor Modulation on Replacement on Rat Skeletal Muscle Cardiomyopathy of the Aging Rat Heart Memory in Aged Mice Aileen Wiglesworth University of Kentucky Ariel Friedman Gerald J. Gracia Quantitative Assessment of Synaptic Density Columbia University 1996 Scholars University of Florida in Superior Parietal Lobule in Alzheimer’s Enhanced Interaction of Advanced Glycation Host Defense Against Influenza in Aged Mice Endproducts (AGEs) with Their Cellular Disease Kristin Baker Receptor RAGE: Implications for the Allen Harrison Tufts University Tong Zhu Pathogenesis of Diabetic Neuropathy University of Michigan Neural Adaptation to Strength Training in the Aging and the Ubiquitination of the CD3-zeta Case Western Reserve University Elderly Aging-related Defects in Complex III of Barry Hoopengardner Chain University of Connecticut Health Center Cardiac Mitochondria Alex Dranovsky Identification of a Temporally-responsive John M. Hollander Stony Brook Medical School, State University Region in the Genome of Drosophila University of Wisconsin, Madison of New York melanogaster Aging and Antioxidant Enzyme Gene 1997 Scholars Role of APP in Microtubule Dynamics Regulation: Superoxide Dismutase Brought Scott Jenkins to Focus Nael Al-Abdulla Michael Eisenbraun University of Alabama at Birmingham University of Michigan Johns Hopkins University School of Medicine Microtubule-associated Protein ß as a Age-sensitive T-cell Subsets Marked by Elizabeth T. Hsiao-Wecksler Neocortical Brain Transplantation to Reverse Signal Transducer: Modulation by Signals P-glycoprotein: Specific Responses to a University of California, Berkeley Neuronal Apoptosis in the Adult Lateral Present in the Alzheimer’s Disease Brain Influence of Lower Extremity Joint Torques Geniculate Nucleus and Restore Connectivity Clonally Restricted Protein Antigen (Pigeon Cytochrome C) on Balance Recovery by Stepping Terry Jones Kaveh Ashrafi University of Kansas Astrid Gutsmann Lyndon Joseph Washington University School of Medicine Functional Consequences of Altered University of Texas Health Science Center University of Arkansas The Role of Protein N-myristoylation in Expression Levels and Conformation of the Weight Loss, Exercise, and Age: Effects on Does Overexpression of HSFI in Human Controlling Survival of Saccharomyces cere- Ryanodine Receptor Calcium Release Insulin Action Diploid Fibroblasts Correct for the Age-relat- visiae During Stationary Phase and Cellular Channel in Aged Skeletal Muscle Aging ed Decline in the Induction of Heat Shock Vivek Kaliraman Protein 70 Expression? James Lee University of Medicine and Dentistry of New Randall Bateman Stanford University Nathan Hall Jersey Case Western Reserve University In Vivo Target Specific Delivery of Role of the SLX Proteins in rDNA Stability University of Cincinnati College of Medicine Human Mesenchymal Stem Cell Interaction Liposome-encapsulated Doxorubicin into and Aging in Yeast Edema Reduction and White Matter with Endothelial Cells During In Vitro Mouse Tumor Model Using Magnetic Protection Following Treatment with a Angiogenesis Resonance Guided Focused Ultrasound Richard Kwun Phenylnitrone Spine Trap in Experimental ICH New York Medical College Tammie Benzinger Paul Mack The Use of Pulse Wave Velocity to Measure Edward Huey University of Chicago University of Georgia Age-related Arterial Stiffening in the Mouse Stanford University Stabilization and Characterization of an Theories of Aging: A Test for the Existence The Intracellular Effects of Stress Hormones Intermediate Conformation of the Beta-amy- of Age-specific Mutations Peter H.U. Lee loid Peptide of Alzheimer’s Disease on Neurons Brown University Lemuel Newton Tissue-engineered BioArtificial Muscles Peter Kennedy Mark Borden University of Florida College of Medicine Transduced with the IGF-1 Gene Can University of Washington Allegheny University of the Health Sciences Enteric Immunization with Recombinant Promote Motoneuron Sprouting and Muscle Mechanisms of Age-dependent Loss of DNA Age-related Effects of Fracture Non-union Vaccinia Virus Fiber Innervation In Vitro Treatment Using a Novel Synthetic Bone Repair Capacity in Human Brain Replacement Christopher Norris Malcolm A. Leissring Steven Kleopoulos University of Virginia Trinity College University of California, Irvine Connie Chen Threshold for a Novel Form of Synaptic Effects of Presenilin-1 on Calcium Signaling Manipulation of Hypothalamic Neuropeptide Johns Hopkins School of Medicine Plasticity: A Link between Ca2+ Regulation Y Gene Expression During Aging The Individual Impact of Dietary Fats and and Impaired Memory During Aging Oren Levy Antioxidant Vitamin Supplements in the Risk Emory University Shi Li of Alzheimer’s Disease Moyosore Onifade Effects of FAD-Linked Presenilin-1 Mutations University California, San Diego on Notch Signaling Washington University School of Medicine Glutamate Transporters and Synaptic Jeff Coombes Role of Astrocytic apoE University of Florida Pathology in Alzheimer’s Disease Marisol E. Lopez The Effects of Vitamin E and Lipoic Acid Christopher Pastore University of Wisconsin, Madison David Lieberman Supplementation on Myocardial Ischemia- Tufts University Characterization of Age-associated Electron University of California, Los Angeles School of reperfusion in Senescent Rats Age Effects on the Proportion and Protective Transport System Abnormalities and Medicine Function of Circulating Endothelial Cell 26 Associated Fiber Atrophy in Rhesus Monkey Second Messenger Actions of Beta-amyloid Progenitors Skeletal Muscle Peptides Srilakshmi Maguluri Kevin King University of Medicine and Dentistry of New 1995 Scholars 1994 Scholars University of Missouri Jersey Genetic Interactions of daf-2 with daf-3 & The Effect of Aging on Rhythmicity Harleen Ahuja Rupinder Bal daf-5 with Respect to Life Span & Larval Queens College Case Western Reserve Development in C. elegans Marta Margeta A Genetic Approach to Understanding Biological Effects of Protein Glycation University of Illinois Molecular Mechanisms of Cell Death Xiao Su G-proteins Involved in the Calcium Curent Deborah Ferrington University of Alabama at Birmingham Inhibition Induced by Substance P and Kaveh Ashrafi University of Kansas FAS Apoptosis and HEPH Function with Aging The Role of Protein Turnover in Aging of the Neurotensin Washington University Protein N-Myristoylation and Cellular Aging Sarcoplasmic Reticulum Ca-ATPase Gina Uken Trebilcock Ewan McNay University of Arkansas University of Virginia Jay Binder Timothy Hughes Role of Transcription Factor Nuclear Factor Determination of the Effects of Aging on Case Western Reserve University Baylor College of Medicine Kappa ß in Aging Probing of Glucose-mediated Crosslinking Initial Work Toward Characterization of the Extracellular Brain Levels of Glucose Sites in Y Crystallins Using Site Directed SDI-3 Gene Melissa Williams Brian Murphy Mutagenesis University of Texas Health Science Center at Washington University School of Medicine Van Khank Huynh San Antonio Role of apoE and LRP in Neuronal Plasticity Kit Mui Chiu Tufts University School of Medicine Construction of a Transgene to be Used in Effect of Aging on the In Vitro Formation of University of Wisconsin-Madison the Production of Transgenic Mice That Effects of Age on Apoptosis of Pig Haloperidol Pyridinium, a Potentially Erik Naylor Overexpress Catalase Northwestern University Osteoblast-progenitor Cell Culture Neurotoxic Metabolite of Haloperidol Novel Animal Model for Exploring the Delay Xiaowei Xu of Sleep and Circadian Rhythms in the Elderly David DiLoreto, Jr. Mark Kadrofske Bowman Gray School of Medicine at Wake University of Rochester Michigan State University Forest University The Effects of Retinal Transplantation on the Regulation of Expression of a Lectin in Lemuel Newton Effects of Age on IGF-signal Transduction University of Florida College of Medicine Age-related Retinal Degeneration in the Senescent Human Fibroblasts Enhancing Influenza Vaccine Effectiveness Fischer 344 Rat Richard Yu Soo-hyun Kim Northwestern University Medical School Jason Ogiste Oren Friedman University of Medicine and Dentistry of New Molecular Response to Inflammation and Cornell University Medical College Thomas Jefferson University Jersey Graduate School of Biomedical Science Aging Redox Regulation of Signal Transduction Replacement of SV40 Tantigen by IRS-1 and Characterization of Growth Suppressor Gene She as Factors in Cellular Transformation on Human Chromosome 6 Andrew Rogove State University of New York, Stony Brook Joshua Garren +PA Mediates Microglial Activation via a Brown University Non-proteolytic Mechanism A Model for Studying Activity-driven Synaptic Plasticity AFAR/The John A. Hartford Foundation Sheila Scoville Eastern Virginia Medical School John Heymach The Impact of Menopause on Primary Stanford University Medical School Academic Fellowship Program in Geriatric Sensory Neurons The Targeting of Neurotraphins and Their Receptors by Neurons Medicine and Geriatric Psychiatry Xiaoming Sun University of Connecticut Health Center Alon Kahana One- to two-year fellowship awards supported the development geriatric Optimal Stimulus Parameters for the University of Chicago and geriatric psychiatry fellows who addressed complex basic, clinical, Measurement of Distortion Product A Genetic and Molecular Investigation of and health services research or educational projects. Sponsored by The Telomere Structure and Function Otoacoustic Emissions in a Mouse Model of John A. Hartford Foundation. This program was active from 1999 to 2002. Presbycosis Christopher Kirk Gina VandenLangenberg University of Michigan University of Wisconsin Role of 14-3-3 Proteins in T-cell Activation: Relationship Between Antioxidant Affects on Aging Victor J. Legner, M.D. Supplement Use and Risk of Age-related 2002 Fellows University of Washington School of Medicine Maculopathy Leslie Pejic The Importance of Medical Comorbidity and University of Illinois at Chicago Julie Bynum, M.D., M.P.H. Preoperative Functional Status in Predicting Johns Hopkins University Tessa Walters Mechanisms of Neuron Aging Functional Decline in Older Adults Analysis of Expenditures for AD Patients The Parkinson’s Institute Undergoing Nonemergent Surgery Biochemical and Immunocyochemical- Michael Rogers Lisa Honkanen, M.D. stereological Analysis of Mouse Nigrostriatal Kent State University Cari R. Levy, M.D. Myosin Heavy Chain Altercations During Weill Medical College of Cornell University Degeneration after Exposure to University of Colorado Health Sciences Center Eight Weeks of Heavy Resistance Training in External Hip Protectors Dithiocarbamates and MPTP Hospital versus Nursing Home: Active Elderly Females Determinants of Site and Cost of Death Grace Y. Jenq, M.D. Conrad Weihl Among Nursing Home Residents Neha Shah Yale University School of Medicine University of Chicago Determining Adherence to a Pain Management Neuronal Gene Delivery via Adenoviruses University of Florida College of Medicine Robert J. Pignolo, M.D., Ph.D. Aging and NPY Expression After Model in the Nursing Home Setting with Bicistronic Constructs in the Study of University of Pennsylvania School of Medicine AAV-Mediated Gene-delivery in Brain The GNAS1 Gene as a Regulator of Selective Motor Neuron Cell Degeneration Jennifer M. Kapo, M.D. Osteoblast Differentiation and Molecular Jordan Shin University of Pennsylvania Amy Whitetree How Can We Improve Services for the Target for the Stimulation of Bone Formation University of Oklahoma Health Sciences Center University of Alabama at Birmingham Fibroblast/Growth Factor Modulates Elderly at the End-of-Life? The Cell Body Response to Axotomy in James L. Rudolph, M.D. Peroxynitrite-induced Apoptosis Aging Motor Neurons In Vitro Reena Karani, M.D. Harvard Medical School Relationship of Intraoperative Trans Cranial Michael Toth Mount Sinai School of Medicine Wenjun Zhang An Evidence-based Unfolding Case with a Doppler (TCD) Output to Delirium in Patients University of South Florida University of Maryland at Baltimore Undergoing Coronary Artery Bypass Graft Energy Metabolism in Congestive Heart Linked Objective Structured Clinical Kainate-induced Expression of Matrix (CABG) Surgery Failure Patients Examination (OSCE) Metalloproteinases in Brains from Old Rats 27 David Sengstock, M.D., M.S. Karol Mansilla, M.D. Cynthia M. Carlsson, M.D. Dellara F. Terry, M.D., M.P.H. University of Michigan Medical College of Virginia University of Wisconsin Medical School at Harvard Medical School Predictors of Orthostatic Hypotension: Non- Mechanisms of Relative Hypogonadism in Madison New England Centenarian Offspring Study invasive Arterial Stiffness Measurement Aging Men The Effect of Folic Acid Supplements on Endothelial Function in Older Adults with Michi Yukawa, M.D. Crystal Simpson, M.D., M.H.S. Stacy Meyer Fischer, M.D. Hyperhomocystinemia University of Washington Johns Hopkins University University of Colorado Health Science Center Involuntary Weight Loss in the Older Adults: Factors Influencing Outcomes for Older The Effects of Palliative Care Education on Cathleen Colon-Emeric, M.D., M.H.Sc The Influence of Cytokines and Leptin African-American Women with Asthma Residents’ Knowledge, Attitudes, and Care Duke University Medical Center of Patients Improving Primary and Secondary Fracture Daniel E. Wollman, M.D., Ph.D. Prevention in Elderly Mount Sinai School of Medicine Jennifer D. Moore, M.D. 1999 Fellows Perfusion MRI of Parietotemporal Cortex Duke University Medical Center Geraldine Fabregas, M.D. Shiraz S. Ahmed, M.D. and Hippocampus in Alzheimer’s Disease A Study to Determine Specific Barriers to a University of Connecticut Health Center University of Washington School of Medicine Good Death at a Tertiary Care, Academic The Effects of Testosterone on Cognitive Physical Function and Aging: Therapeutic Laurel B. Yates, M.D. Medical Center and to Initiate Change Function in Men with Early Cognitive Decline Potential of Estrogen and Testosterone Harvard Medical School Beyond Bone Density: A Prospective Study Jennifer Rhodes-Kropf, M.D. Helen M. Fernandez, M.D. Ali Ahmed, M.D. of Hip Geometry and Structural Differences Mount Sinai School of Medicine Mount Sinai Medical Center University of Alabama at Birmingham as Predictors of Hip Fracture Among Elderly How Interns Learn to Care For Dying Patients House Staff Awareness of their Older Association of Hospital Care Quality with Long-term Care Residents Inpatients’ Risks for Developing ’Hazards of Heart Failure Mortality and Readmissions Robert G. Riekse, M.D. Hospitalization’ University of Washington School of Medicine Jacob Blumenthal, M.D. Vascular Risk Factors in Alzheimer’s Patients Julie K. Gammack, M.D. University of Maryland School of Medicine 2001 Fellows With and Without Cerebral Vascular University of Washington The Neuropeptide Y1-Y5 Receptor and its Infarctions: A Clinico-neuropathological Development of an Expanded Geriatric Howard J. Aizenstein, M.D., Ph.D. Relationship to Obesity and Diabetes Mellitus Study Curriculum for Internal Medicine Residents University of Pittsburgh Medical Center and Medical Students at the University of Functional MRI Investigations of the Stephen Bonasera, M.D., Ph.D. Xiangrong Shao, M.D. Washington Medical Center Frontostriatal System in Late-life Depression University of California, San Francisco University of Maryland School of Medicine 5 HT Receptor Subtypes: Molecular and Longitudinal Assessment of Functional Robert C. Blackmon, M.D. Wendolyn S. Gozansky, M.D., M.P.H. Behavioral Approaches to Study the Performance in Older Peripheral Arterial Medical College of Virginia University of Colorado Health Sciences Center Regulation of Posture and Locomotion Disease Mechanisms of Visceral Fat Accumulation in Does Reading Religious Literature Reduce Older Women Cortisol Secretion in Elderly Patients? Ursula Braun, M.D. Lisa M. Walke, M.D. Baylor College of Medicine Yale University School of Medicine Cynthia M. Boyd, M.D., M.P.H. Mitchell T. Heflin, M.D. A Brief Cognitive Behavioral Intervention to Longitudinal Study of the Burden of Johns Hopkins University School of Medicine Duke University Medical Center Improve Functioning in Elderly Patients with Symptoms Among Community Dwelling Screening for Occult Malignancy in the Elderly Hospitalization and Disability in a Cohort of Chronic Obstructive Pulmonary Disease Elders with Terminal Diseases Moderately to Severely Disabled Older Cynthia Holzer, M.D. Women Jessica L. Israel, M.D. Chia-Ying Wang, M.D. University of Cincinnati Mount Sinai School of Medicine University of Texas Southwestern Medical Do Beliefs and Attitudes about Dementia Cynthia J. Brown, M.D. Breaking Bad News to Older Adults Create Barriers to Appropriate Preventive Yale University School of Medicine Center The Effect of Potassium Citrate on Calcium Care? Immobility in the Hospitalized Elderly Patient: Laurie L. Lavery, M.D. Balance and Bone Metabolism in Healthy Prevalence and Impact on Functional Decline University of Pittsburgh Elderly Women\ Peifeng Hu, M.D., Ph.D. Are Long-term Care Needs Predicted by University of California, Los Angeles School of Bruce Carruthers Bonnell, M.D. Screening for Executive Control Dysfunction? Harvard Medical School Heidi R. Wierman, M.D. Medicine Pathophysiologic Mechanisms for Low Medications as Risk Factors for Falls Among University of Rochester School of Medicine Cathy Lee-Chopra, M.D. Novel Methods for Functional Assessment Serum Cholesterol and High Mortality the Hospitalized Elderly University of Michigan Association in the Elderly Population Effect of Raloxifene on Insulin Sensitivity in Yohannes Endeshaw, M.D., M.P.H., 2000 Fellows Postmenopausal Women F.A.C.P. Lona Mody, M.D. Emory University School of Medicine Julie Beales, M.D. University of Michigan Erik J. Lindbloom, M.D. Clinical Outcomes of Community Acquired Is Obstructive Sleep Apnea More Prevalent Medical College of Virginia University of Missouri at Columbia Pneumonia in the Elderly: Importance of in Older Adults with Nocturia Compared to Does the Resident Assessment Instrument The Missouri Elder Mistreatment Fatality Study Functional Status Older Adults without Nocturia? Improve Identification and Treatment of Pressure Ulcer or Falls James M. Martau, M.D. Karen E. Glasser Scandrett, M.D. Karen A. Morgan Blackstone, M.D. University of Colorado Harvard Medical School Malaz Boustani, M.D. Harvard Medical School Evaluation of Nursing Home Quality Since The Response of Elders with Impaired Measures of Religiosity in a Frail and Aged University of North Carolina the Implementation of the Resident Bladder Emptying to Pharmacologic Jewish Population: Validity and Application Clinical Trial of the Effect of Donepezil on Assessment Instrument Treatment for Urge Incontinence Aggressive Behavior in Institutionalized Michele Y. Lee, M.D. Persons with Moderate/Advanced Dementia William G. Seavey, M.D. , M.P.H. Maj-Stina L. Rudolph, M.D. University of New Mexico and Severe Behavioral Problems University of California, Davis Hospice/Palliative Care Training of Family University of California, Los Angeles Evaluation of a Community-based Telephone A Randomized, Double-blind, Placebo-con- Practice Residents Donna M. Brady Raziano, M.D., M.B.A. Intervention to Increase Physical Activity trolled Study of S-adenosylmethionine in the University of Pennsylvania Among Seniors Treatment of Alzheimer’s Disease Felice LePar, M.D. Do ACE Units Work? University of Pennsylvania School of Medicine Older Cancer Patients’ Attitudes Toward Jennifer B. Breznay, M.D. Joseph Shega, M.D. Participation in Research Mount Sinai School of Medicine University of Chicago Enteral Nutrition - Who Should We PEG Communication Among Health Professionals next? Reasons for Percuteneous Endoscopy Stacie Levine, M.D. in the Home Care Setting Mount Sinai School of Medicine Gastrostomy Tubes in Endstage Dementia Risk Factors and Outcomes in Hospitalized Patients Adults over Age 85 28 Shawn Rosen Laurel E. Blackman University of Rochester School of Medicine University of North Texas Health Science Medical Student Summer Research Training Center- Texas College of Osteopathic Medicine Alexandra Shaw in Aging Program Mount Sinai School of Medicine Brittany N. Bohinc Northeastern Ohio Universities College of (formerly known as the Medical Student Geriatrics Scholars Program) Megan Skibitsky Medicine University of California, Los Angeles Eight- to twelve-week awards encourage medical students — particularly Yasmin Bootwala budding researchers — to undertake research projects and consider a career Lon Steinberg Baylor College of Medicine Albert Einstein College of Medicine in geriatrics. AFAR collaborates with the NIA and several foundations to Catherine Buell continue and strengthen the original Hartford/AFAR Medical Student Malini Sur Drew University/University of California, Los Geriatric Scholars Program. Current sponsors include: National Institute on Mount Sinai School of Medicine Angeles Aging, The John A. Hartford Foundation, The William Randolph Hearst Foundation, The Cleveland Foundation, Cardinal Health Foundation, Lillian Ryan Takenaga Julie Burke R. Gleitsman Foundation, Community Health Foundation of Western & Johns Hopkins University School of Medicine Saint Louis University School of Medicine Central New York, The New York Community Trust and an anonymous donor. Ezra Teitelbaum Joel Escobedo The Fan Fox and Leslie R. Samuels Foundation was a sponsor from 2000-2003. Mount Sinai School of Medicine University of Michigan

Christie Tung Anne E. Finefrock Case Western Reserve University University of North Carolina at Chapel Hill

2005 Scholars Jacqueline Green Brant Ullery Maximilian Gomez-Trochez Emory University Cornell University Mount Sinai School of Medicine Alan Bengtzen Emory University Joy Guerrieri-Bang Ryan Ungaro Matthew Hansen University of New England College of Medicine Mount Sinai School of Medicine Case Western Reserve University Ariel Bulua Mount Sinai School of Medicine Nitin Gupta Deborah Weener Maryam Haque University of Michigan University of Michigan Drexel University College of Medicine Olatubosun Chinwokwu Saint Louis University Elizabeth Harlow Daniel Wei Lianne Hirano Emory University Case Western Reserve University Yale University Neela Dasgupta Johns Hopkins School of Medicine Ben Harris Victor Wu Joey Y. Kohatsu Mount Sinai School of Medicine Emory University University of Hawaii Ohm Deshpande Cornell University John Hopkins Priscilla Yee Melissa H. Kujawski University of North Carolina at Chapel Hill John A. Burns School of Medicine at the Mount Sinai School of Medicine Sharon Engel University of Hawaii at Manoa Emory University David Horowitz Margaret W. Leung Johns Hopkins University School of Medicine Jacqueline Yuen University of California, San Diego David Fish University of Michigan Medical School University of New England College of Medicine Brian Houston Cathy Liu Emory University Andrea Zapeda Emory University Andrew Fisher University of Michigan University of Pittsburgh School of Medicine Kathleen Khong Jeffrey Loh Northwestern Feinberg School of Medicine David Zinn Cornell University Michael Ford Brown University Cornell University Sandy Liang Aleicia R. Mack Mount Sinai School of Medicine Oklahoma State University Daniel Freedberg 2004 Scholars Harvard Medical School Kyauna Miller Kristin K. Martin Case Western Reserve University Yachna Ahuja Case Western Reserve University Oklahoma State University Molly Fuentes University of Michigan Medical School Margaret Moscato Loren L. Martinez Emory University Hannah H. Alphs Johns Hopkins University Ohio State University College of Medicine and Gina Fujikami Public Health John A. Burns School of Medicine at the Anjali Nigalaye Kathryn A. Artis University of Hawaii at Manoa University of Chicago Mount Sinai School of Medicine Matthew Mei Case Western Reserve University Shanti Ganesh Shantanu Nundy Donald M. Banik Duke University School of Medicine Johns Hopkins University School of Medicine University of New England College of Medicine Meredith J. Montero University of Michigan Matthew Garrett Theodore Pasquali Aisha Baqai Case Western Reserve University University of California, Los Angeles Cornell University Leah Y.K. Nakamura University of Hawaii Benjamin Goldsmith Laura Raducha-Grace Russell Berger Mount Sinai School of Medicine University of Pittsburgh Mount Sinai School of Medicine Claude Nguyen Medical College of Wisconsin Elizabeth Goodman Simha Ravven Gwen Bernacki Washington University School of Medicine Tulane University School of Medicine State University of New York, Buffalo Barbara C. Overend Emory University 29 Brandon Roberts Case Western Reserve University Hasra K. Phillip Shannon M. Campbell Monica G. Majmundar State University of New York, Upstate Medical Ohio University College of Osteopathic Emory University 2002 Scholars University Medicine Danielle A. McClellan Stephanie J. Anderson Saint Louis University Lhasa Ray Connie Chang Saint Louis University Albert Einstein College of Medicine Cornell University Daniel F. Motter Srilatha Atluri Indiana University School of Medicine Donna J. Roybal Joseph C. Chiang Philadelphia College of Osteopathic Medicine University of California, Los Angeles Mount Sinai School of Medicine C. Ariel Nason Isabel Balderas Harvard University Sima Shah Anne K. Chung Boston University Case Western Reserve University University of Arizona Anoma Nellore Amy Baxi Saint Louis University Marc P. Simpao Jarrod Collings University of Pennsylvania University of Texas Health Science Center at University of North Texas Health Science San Antonio Center Michael Nystrom Julia B. Becker University of California, Los Angeles University of Michigan Anthony N. Sireci Luis G. Cruz Johns Hopkins University University of Hawaii Monica I. Oshita Pablo E. Bedoya University of Hawaii Emory University Risa Small Kirsten Dacal Mount Sinai School of Medicine University of Pittsburgh Joon Hong Park Michael A. Blair University of Virginia School of Medicine University of Maryland, Baltimore Amir Soumekh Dilsher S. Dhoot Mount Sinai School of Medicine Chicago Medical School Schonze F. Peck-Del Pozo Jessica K. Bland Johns Hopkins University University of Texas Health Science Center at San Antonio Hana Takusagawa Kerry A. Donegan Mount Sinai School of Medicine Mount Sinai School of Medicine Angela S. Peng University of Texas Health Science Center at Jonathan Blau State University of New York, Stony Brook Joseph Tang Margaret Donlon San Antonio Mount Sinai School of Medicine University of Rochester Christopher H. Perkins Catherine A. Bluteau University of Michigan Sarah K. Tighe Steven D’Sa Baylor College of Medicine Johns Hopkins University University of Michigan Tracy Prachthauser Brooke N. Bosley University of Pittsburgh Elizabeth H. Tsai Rachel Fogel Medical College of Wisconsin University of Medicine and Dentistry of New Johns Hopkins University Jersey School of Osteopathic Medicine Carl T. Ratliff, Jr. Kathryn E. Callahan Mount Sinai School of Medicine Michael C. Forney Ohio University College of Osteopathic Veronica Vasquez Case Western Reserve University Medicine Cornell University Amy Carroll Emory University Katherine Freeman Elizabete M. Santos Giorgio Veneziano Northeastern Ohio Universities College of University of New England College of Case Western Reserve University Medicine Osteopathic Medicine Richard B. Carter, Jr. Baylor College of Medicine Pauline Wu Ewina Fung Sarah Schellhorn University of Medicine and Dentistry of New University of California, Los Angeles Cornell University Yamileth R. Cazorla-Lancaster Jersey School of Osteopathic Medicine University of North Texas Health Science Center Matthew R. Garrett Shauna Schwartz Cong-Zhi Cecile Zhao Case Western Reserve University State University of New York, Stony Brook Medical College of Wisconsin Kenneth V. Chong New York Medical College Anne D. Halli Sona S. Shah University of Alabama, Birmingham Emory University 2003 Scholars Jessica Colburn University of Pittsburgh Crystal L. Adams Mary J. Hessert Janet E-H Shu University of Texas Health Science Center at University of New England College of Brown University Osteopathic Medicine Alan Coon San Antonio Saint Louis University Jennifer N. Stojan University of Michigan April Alford Christopher A. Jones Jefferson Medical College Rahul Desikan Baylor College of Medicine Boston University Kathleen A. Walker Medical College of Ohio Jonathan Austrian Beth H. Justice Emory University Kimiko Domoto-Reilly Cornell University New York Medical College Melanie C. Wuerstle University of California, Los Angeles Lisa M. Bowe Christin Knowlton State University of New York, Stony Brook Lanelle Dulloog Ohio State University University of Hawaii Anthony Yin Saint Louis University Daniel J. Burdick Thomas A. Leeson University of New England College of Paul Edwards Johns Hopkins University University of Arkansas Osteopathic Medicine Beata Zubrowski Philadelphia College of Osteopathic Medicine Michelle M. Cabrera Michael Ehrlich University of Maryland School of Medicine Serena Lo University of Hawaii Jefferson Medical College 30 Rebecca Epstein Indiana University Tina Fan Rose Khavari Jeanne B. Robinson Christopher Vernon Mount Sinai School of Medicine University of Texas Medical Branch Baylor College of Medicine Western University of Health Sciences

Laura Fanning Heidi A. Koerner Carmela Rocchetti Naveed Wagle Cornell University University of South Dakota Robert Wood Johnson Medical School at the Chicago Medical School University of Medicine and Dentistry of New Alla Feldbarg Izabela Koprowska Jersey Dexter Wong City University of New York Medical School State University of New York, Downstate Boston University Bunja Rungruang Scott J. Genshaft Meenal G. Kulkarni University of Alabama, Birmingham Irene Wu Case Western Reserve University Northeastern Ohio Universities College of University of Medicine and Dentistry of New Medicine Amy Rybak Jersey Lisa Giuli Ohio University College of Osteopathic Cornell University Lawrence D. Lazar Medicine Brett Yamane University of California, Los Angeles University of Hawaii Sheena Gleason Marja Samenfeld-Specht Saint Louis University Andrew B. Lee Mount Sinai School of Medicine Sallis Yip Washington University University of Hawaii Andrew Godbey Christopher Sciortino Saint Louis University Wei Wei Li Case Western Reserve University Chung Chi Yu Sophie Davis School of Biomedical Education Albert Einstein College of Medicine Karim Gokal at the City University of New York Karen Shahar Emory University Baylor College of Medicine Elaina E. Lin 2001 Scholars Johns Hopkins University Mark L. Gripp Jeremy Shelton Jennifer N. Alzos Mount Sinai School of Medicine Cornell University Weill Medical College of Cornell University Nicole Longanecker Vanderbilt University Divya Gupta Sara M. Shunkwiler Suzanne V. Arnold Northwestern University Medical School University of Iowa Ohio State University Aisha Macedo Mount Sinai School of Medicine Nancy Han Stephanie A. Sieg Karen Au Ohio State University Ohio University College of Osteopathic University of Pittsburgh Anne Mani Medicine Johns Hopkins University Salma Haque Sunyata Austin Louisiana State University Gabriel K. Silverman Ohio University Kara B. Markham University of Pittsburgh University of Michigan Lindsey Hartmann Sarah Babineau University of Nebraska Marc P. Simpao Brown University Veronica Mendoza-Jenkins University of Texas Health Science Center at University of Washington San Antonio Peyton L. Hays James F. Bartscher Cornell University Weill Medical College of Cornell University Aaron K. Mory Toby Smith Thomas Jefferson University Western University Hebah M.S. Hefzy Michon Bechamps Northeastern Ohio Universities College of Eastern Virginia Medical School Medicine Megan B. Muilenburg Lauren Snow University of North Dakota Mount Sinai School of Medicine Paula Becker Jeffrey S. Highfill Saint Louis University University of Pittsburgh Jae H. Park Tien-I Karleen Su Johns Hopkins University University of California, Los Angeles Robert Bercovitch Susan A. Hodes Brown University University of California, Irvine Atisha Patel Demian Szyld Baylor College of Medicine Mount Sinai School of Medicine Christina Bertao Julia Hsu University of Hawaii Boston University Avni Patel Tomoko Tagawa University of Pittsburgh Finch University/Chicago Medical School Lindsay-Rose Boynton Tracy N. Huynh University of Michigan Boston University Oscar E. Penate Connie K. Tang University of Washington Ohio State University Lynsey E. Brandt Kelly J Ishizuka University of Pittsburgh Ohio State University Carmel Person Monica L. Tegeler University of Louisville Saint Louis University Shu-Hong Holly Chang D. Krysten James Johns Hopkins University University of Texas Health Science Center at Joshua D. Phillips Katheryn Thomas San Antonio University of Nebraska College of Medicine Emory University Elaine Cheng Weill Medical College of Cornell University Beverly K. Johnson Christine Pineda Justin To Brown Medical School University of Washington State University of New York, Stony Brook Sze Mei Chung University of Hawaii Elizabeth A. Johnson Angela Poppe Carmen A. Traywick Medical College of Wisconsin Duke University Emory University Calandra Diamond Western University Rebecca Jones Rajeev Raghavan W. Jeff Triffo University of Alabama, Birmingham Ohio State University Baylor College of Medicine Marcie Dreisbach Ohio State University Abha Khandelwal Kristen N. Rice Jadwiga J. Truty 31 Ohio State University University of Colorado University of California, Los Angeles Justin O. Endo Diane M. Lewis George C. Tsao Ji-Eun Susana Choi University of Nebraska State University of New York, Stony Brook Western University Albert Einstein College of Medicine

Joshua T. Evans Lesley L. Liu Kathleen T. Unroe Neil M. Coleman Saint Louis University University of Kansas Ohio State University University of Kansas

Martin Evers Jennifer G. Magalong Sandra D. Vale Kathleen M. Coyle Mount Sinai School of Medicine Midwestern University University of Texas Health Science Center at Jefferson Medical College San Antonio Jessica A. Evert Sterling L. Malish Maria E. Duda Ohio State University University of Hawaii Sarah J. Van Epp Weill Medical College of Cornell University University of Nevada, Reno Elizabeth Fabre Lara Marcuse Michael Einstein Saint Louis University Albert Einstein College of Medicine Nicholas J. Van Wagoner Mount Sinai School of Medicine University of Alabama, Birmingham Cory R. Fraser Susan E. Merel Martin Evers University of Hawaii University of Chicago Margaret S. Vandewater Mount Sinai School of Medicine Emory University Marissa E. Garza Terrace R. Mucha Michael Fang University of North Texas Health Science Ohio State University Karen H. Wang Northwestern University Center- Texas College of Osteopathic Medicine Baylor College of Medicine Sara K. Pasquali Parisa Farhi David Geist Duke University Michelle D. Waugh University of Pittsburgh Yale University University of Texas Health Science Center at Vasum Sri Sampath Peiris San Antonio Kelly Ann Gallina Katherine E. Greco University of Vermont Northeastern Ohio Universities Emory University Andrew Wong Kenan Penaskovic Weill Medical College of Cornell University Katherine S. Garman David Halpern University of Alabama, Birmingham Duke University Weill Medical College of Cornell University Jennifer Yates Mariah A. Quinn Saint Louis University Margaret H. Genovesi Daena Heller Weill Medical College of Cornell University Mount Sinai School of Medicine State University of New York, Downstate Seth Resnick 2000 Scholars M. Mehdi Ghajarnia Mount Sinai School of Medicine University of Pittsburgh Amanda M. Hough David Aaronson University of Michigan Mount Sinai School of Medicine Frederick C. Roediger David Gidseg Weill Medical College of Cornell University Weill Medical College of Cornell University Rania Ibrahim Daniel E. Abbott Western University University of Washington Tara Sanft Sukara Gregory Medical College of Wisconsin Ohio State University Christine Jensen John Abbott University of Washington Emory University Jennifer Sardone Rhea A. Hartley Ohio State University University of Kansas Leslie Judd Craig Alguire University of California, Los Angeles University of Michigan Lewis Satterwhite Jacquelyn Hartzler Emory University Emory University Sammy S.W. Kang Tresa Almy-Albert University of Maryland University of Rochester Jennifer N. Schwartzhoff Douglas E. Holt Emory University University of Pittsburgh David Kessler Stefen M. Ammon Mount Sinai School of Medicine University of Colorado Health Sciences Center Louisa Shair Andrea Hsia State University of New York, Downstate University of Miami School of Medicine Melissa D. Koehler Suzanne V. Arnold University of North Texas Health Science Ohio State University Health Sciences Center Center-Texas College of Osteopathic Medicine Melissa J. Sherman Laura Hurst University of Pittsburgh Ohio State University Morad Askari Kimberly A. Kregoski University of Pittsburgh Wayne State University Rebecca Starr Tamara Isakova State University of New York, Downstate Sophie Davis School of Biomedical Education Amsalu Bizuneh Jennifer M. Krejci-Manwaring Emory University at the City University of New York University of Texas, Houston Joshua R. Steinerman State University of New York, Downstate Barbara M. Blumer Catherine E. Johnson Aileen Langston University of Kansas Weill Medical College of Cornell University Baylor College of Medicine Heather C. Tauschek Weill Medical College of Cornell University Holly N. Burford Eric N. Kagaruki Emily E. Lazarou University of Alabama, Birmingham Ohio University College of Osteopathic University of Texas Health Science Center at Gregory L. Taylor Medicine San Antonio Howard University Carol Y. Chang Western University of Health Sciences Reiko Kayashima Bryan S. Lee Bob Thong University of Hawaii Washington University University of Washington Janet J. Chieh Robert Wood Johnson Medical School at the Benjamin Kim Cheri Leng Emily Triana University of Medicine and Dentistry of New Northwestern University University of Washington Baylor College of Medicine Jersey 32 Eleanore T. Kim Weill Medical College of Cornell University Kristen M. Kiser Pam R. Rajendran James B. White Catherine D. Hoang University of Washington Boston University University of Alabama, Birmingham Chicago Medical School

Deborah A. Koehn Timothea Ryan Michael White Craig J. Johnston Medical College of Virginia University of Pittsburgh University of North Texas Health Science University of Washington Center Anna Kovalszki Roland I. Saavedra Hannah T. Jordan University of Michigan Finch University Medical School/The Chicago Shawn Wilker Mount Sinai School of Medicine Medical School Case Western Reserve University Katherine M. Krajewski Padmini Kaushal Wayne State University Amit A. Shah Deborah C. Yeh University of Vermont Baylor College of Medicine Harvard University Jennifer M. Krejci-Manwaring Michelle Keith University of Texas, Houston Chelsea Sheppard Jeanette Yu Baylor College of Medicine Saint Louis University Northwestern University Anjuli Kumar Emmalee Kennedy Cornell University Kelly A. Shimabukuro Lawrence Zeidman Northwestern University Mount Sinai School of Medicine Northwestern University Kindra Larson Dorothy P. Khong University of Washington Amy Simon University of California, Riverside MCP Hahnemann University 1999 Scholars Emily E. Lazarou Andrew Bohmart Gene Kim University of Texas Health Science Center at Kimberly Siu Mount Sinai School of Medicine Indiana University School of Medicine San Antonio University of Hawaii Kari L. Case Raymond Klug Aaron Lear Danielle Skirchak University of Washington Finch University Medical School/Chicago Ohio State University University of Kansas Medical School Joy T. Catolico Paula M. Lee-Valkov Adam H. Skolnick Ohio State University Aileen Langston Baylor College of Medicine Brown University Baylor College of Medicine Monique Chang Shelley G. Lenamond Michael Smith Mount Sinai School of Medicine Gary J. Lelli, Jr. University of North Texas Health Science Saint Louis University Mount Sinai School of Medicine Center Anna I. Cheh Jalal Soltanian-Zadeh University of California, Los Angeles Jamesetta H. Lewis Robin Levenson Ohio University College of Medicine Ohio University College of Osteopathic Indiana University Medicine Edwin S. Chen Sophie D. Stein Medical College of Ohio Cecily Ling Robert Wood Johnson Medical School at the Betty Lim University of Hawaii University of Medicine and Dentistry of New University of Buffalo David Cognetti Jersey University of Pittsburgh Jeffrey Liu Sung E. LoGerfo Weill Medical College of Cornell University University of Washington Ik Hyun Sung Rebecca N. Cohen MCP Hahnemann School of Medicine Mount Sinai School of Medicine Esther Lu Jennifer Main Mount Sinai School of Medicine University of Rochester Henry Tang Nathaniel A. Davenport Western University of Health Sciences University of Washington Amanda F. Lucero Michele Mak Mount Sinai School of Medicine Yale University Phu Binh Thai Lucy M. Douglass Emory University University of Washington Edna Ma Todd McCall University of Colorado University of Washington Leila C. Thanasoulis Laura N. Frain Louisiana State University Harvard University Thomas J. May Robert N. McLay University of North Texas Health Science Tulane University Katheryn J. Thomas Benjamin J. Friedman Center Emory University Finch University Medical School/Chicago Medical School Anastasia L. Misakian John P. Murray David E. Traul University of California, San Diego Duke University Medical College of Ohio Mark Gamber University of North Texas Health Science Steven H. Mitchell Lyssa N. Ochoa Alexander C. Tsai Center University of Washington Baylor College of Medicine Case Western Reserve University Jennifer Goerbig Jeffrey B. Muehling Heather C. O’Donnell Sing Tsai University of Michigan University of Washington Washington University University of Pittsburgh Amy Gross Delma J. Nieves Clifton L. Page Scott Turner Allegheny University of the Health Sciences University of Washington Ohio State University Saint Louis University Jeffrey A. Gusenoff Tanya L. Page John J. Palmieri Asit A. Vora Johns Hopkins University Mount Sinai School of Medicine Mount Sinai School of Medicine University of South Carolina Sandra P. Gutierrez Sunil M. Patel Amy M. Parish Brent R. Weed Ohio University College of Osteopathic University of Pittsburgh University of Kansas University of Nevada Medicine Monica T. Peterson 33 Camille Pedigo Saint Louis University Emory University Laura Phang John A. Guerriero Lisa M. Manimala University of California, San Francisco 1998 Scholars Ohio University College of Osteopathic University of Rochester Medicine Ashutosh A. Pradhan Yeran Bao Thomas A. Manning University of California, Los Angeles Duke University Verna C. Guo University of Arkansas for Medical Sciences Northwestern University Cynthia I. Resendez Jeremy R. Bariola Rotonya L. McCants University of Arkansas for Medical Sciences University of California, San Francisco Heidi J. Haapala Cornell University Medical College University of Michigan Todd E. Schmidt Michael R. Bibighaus Gina M. Merritt Johns Hopkins University Indiana University Randall K. Harada Ohio University College of Osteopathic University of Pittsburgh Medicine Lauren K. Schwartz Doug Borg University of Arkansas for Medical Sciences Cornell University James C. Hardy Kathleen M. Mitchell University of Washington Saint Louis University Jeffrey R. Scott Heather E. Brooks University of Pittsburgh University of Washington Kevin M. Henderzahs Smita Nayak Indiana University Hackensack University Medical Center Joanna B. Sheinfeld Jeremy D. Bufford University of Arkansas for Medical Sciences Yale University Hilary M. Hochberg Huy V. Nguyen Cornell University Medical College University of Washington Elliott Sohn Ian S. Caccam University of Miami School of Medicine University of Washington Emily E. Hooi Michael H. Nguyen Ohio State University University of California, Los Angeles Angela Y. Song Kerri L. Cavanaugh Yale University University of Pittsburgh Evaleen F. Hsieh Cynthia Y. Ohata University of Miami School of Medicine University of Washington Rui Song Roger S. Chan University of California, San Diego Case Western Reserve University Chandra M. Ivey Mihwa C. Pak Cornell University Medical College Chicago Medical School Ellen E. Squire Peter J. Chase Saint Louis University Kansas University Medical Center Randall E. Jack Jonathon D. Palmer University of Nevada, Reno University of Arkansas for Medical Sciences Craig Stewart Johnson Y. Chiu Saint Louis University Indiana University Sherry L. Johnson Tahira A. Palmer Ohio University College of Osteopathic University of Alabama Calvin G. Sy Sarah J. Crane Medicine Saint Louis University University of Pittsburgh Amie L. Peterson Cornelia M. Kacir Medical College of Georgia Melba M. Taylor Jessica Critchfield Ohio University College of Osteopathic University of Washington University of Washington Medicine Anthony T. Pham University of North Texas Health Science Jo-Anne Teoh Joy E. Cuezze Jonathan Kantor Center Saint Louis University University of Kansas Medical Center University of Pennsylvania Basil Pittenger Nghi K. Tran Carrie A. Czarnecki Youjeong Kim University of Washington University of Michigan Saint Louis University University of Texas, Houston Medical School Catherine J. Rees Stephanie N. Turnage Anne B. Davis Karen M. Knops Wake Forest University Ohio State University University of Alabama, Birmingham University of California, Los Angeles Brent Ridge Jay Ufford Dustin L. Dierks Negar G. Knowles University of North Carolina at Chapel Hill Mount Sinai School of Medicine University of South Dakota School of Medicine University of Washington Matthew J. Robon Wendy D. Wasden Mark T. Dillon E. Scott Kopetz Ohio State University University of Alabama, Birmingham University of Michigan Johns Hopkins University Jennifer L. Rupert Jonathan D. Weaver Lisa M. Filion Elizabeth M. Kwong University of Washington University of California, Los Angeles University of Washington University of California, San Diego Sepehr B. Sani Melissa F. Wellons LaTosha Y. Flowers Melinda J. Landchild Medical College of Ohio Duke University School of Medicine University of Arkansas for Medical Sciences University of Washington Elizabeth A. Schneider Haoling Holly Weng Tanya E. Froehlich Anthereca E. Lane University of Arkansas for Medical Sciences Duke University Yale University Ohio State University Melinda P. Shaw Barton L. Wise Jennifer R. Garreau Janie M. Leonhardt Emory University Boston University University of California, Los Angeles Northeastern Ohio Universities College of Medicine Grace L. Shih Terri L. Woodard Jonathan B. Gill Yale University University of California, Los Angeles University of Pittsburgh Jimmy M. Liao University of Michigan Jill Z. Simon Jason Yeh Philip F. Gogel Cornell University Medical College Saint Louis University University of California, Los Angeles Tina M. Lusignolo 34 Ohio State University Sarah M. Snelgrove Jennifer Jackson Neha Sangwan Cornell University Medical College 1997 Scholars University of Pittsburgh School of Medicine University of Buffalo

Natalie P. Steele Tanya Barauskas Jason Kahn Donna Sassaman University of Washington University of California, Los Angeles University of Rochester University of Medicine and Dentistry of New Jersey Michael E. Stern Julie Bartik Kevin Kerber Ohio University College of Osteopathic Cornell University Medical College University of South Carolina School of Mary Sehl Medicine Medicine Brown University Michael M. Takamura University of California, San Diego Naveena Bobba Aaleya Koreishi Victoria Sokolove University of Pittsburgh University of Michigan University of Pennsylvania Sonja L. Talvi University of Chicago Deborah Boyle Jacqueline Kramer Timothy Ta University of Massachusetts Indiana University Medical College of Wisconsin William H. Thom Saint Louis University Karl Buekers Sandhya Krishnan William Tew Ohio State University University of Michigan University of Rochester Keith Thompson University of Arkansas for Medical Sciences Ian Caccam Alayne Kulvicki Blake Weathersby University of Miami University of North Texas Health Science University of Alabama School of Medicine Nyree K Thorne Center State University of New York, Syracuse Health Milan Chheda Heather Whitson Albert Einstein College of Medicine Science Center James Lai Cornell University Bowman Gray School of Medicine at Wake Mark C. Tsai Kara Cummins Forest University Cecilia Wieslander University of Pittsburgh Saint Louis University University of California, Los Angeles Dawn Lazarus Lauren G. Varney Tracy DeAmicis Mount Sinai School of Medicine Jennifer Winters Tufts University School of Medicine Johns Hopkins University Ohio University College of Osteopathic David Lieberman Medicine Gina R. Vaughn David DeGuzman Stanford University University of Michigan University of Washington David Wu Ronnie Lu University of Michigan Ariana J. Vora Nancy Dunbar Boston University University of Connecticut Health Center Mount Sinai Medical Center Carrie Zimmer Kimberly Mark University of Michigan Vicki K. Wall Arom Evans University of South Dakota University of Nevada, Reno University of Washington Silbey Mui 1996 Scholars Thomas H. Watson Darlene Gabeau Albert Einstein College of Medicine Yale University Matthew Anderson Emory University University of South Dakota Mark Musco Alyssa N. Wenger David Ganz Chicago Medical School Harvard Medical School Alex Auseon University of Arkansas for Medical Sciences Ohio University College of Medicine Shyam Parekh Beverly E. White Colin Gillespie University of Michigan Finch University of Health Sciences Todd Bailey Baylor College of Medicine Saint Louis University Andreea Partal Susan M. Womeldorf Shannon Grosdidier Case Western Reserve University University of South Dakota Gavin Baumgardner Oregon Health Sciences University Ohio University College of Medicine Stephanie Peppler-Swope Andrea Wong Colin Hamblin Saint Louis University University of Rochester Christine Bittner University of Medicine and Dentistry of New Ohio University College of Medicine Jersey Supriya Rajpal James Hekman University of Michigan University of Chicago David Broumandi Christine A. Wu Emory University University of California, Los Angeles Louis Ramos Aram Hezel University of Rochester State University of New York, Buffalo Kathleen Burgess Zimu N. Zheng University of Washington University of California, San Diego Alvie C. Richardson Rhadjena Hilliard University of Nevada, Reno, School of Medicine Mount Sinai School of Medicine Craig Calhoun Saint Louis University John Rogowski Cheryl Ho University of California, Los Angeles University of California, San Diego Scott Carlos University of Michigan Andrew Ross Kristin Humphreys Mount Sinai School of Medicine The Pennsylvania State University College of Michael Chen Medicine University of Michigan James Rudolph Loyola University Chicago Stritch School of Lillian Chiang Joachim Ix Medicine University of Chicago Pritzker School of University of California, Los Angeles Medicine Tanya Ruff Ohio State University 35 Yu-Chi Chung Babak Mokari Ruth Graupera University of Texas Health Science Center at Ohio University College of Osteopathic 1995 Scholars Johns Hopkins University San Antonio Medicine Julie Abrahamson Jennifer Grot Johns Hopkins University Paul Cunningham Laurie Muller Saint Louis University University of Washington Saint Louis University Eugene Ahn Lucy Guerra New York University Medical Center Dolon Das Ryan O’Connell Mount Sinai School of Medicine Baylor College of Medicine New York University Angela Allen Susan Hall Saint Louis University Mohak Dave Ghadir Oloumi Loma Linda University University of South Carolina Mount Sinai School of Medicine Rendell Ashton Sara Howe Johns Hopkins University Linda V. DeCherrie Vipul Parikh New York Medical College University of Chicago University of Michigan Neeraj Badjatia Jordan Karp Emory University Michael Feloney Luon Peng University of Pittsburgh Saint Louis University Ohio University College of Osteopathic Medicine James Boyd Pamela Kirschner Saint Louis University Debbie Fishkind Harvard University Mount Sinai School of Medicine Hoang Pham University of Pennsylvania D. Allen Brantley Alayne Kulvicki Markland Wake Forest University Suet-Ying Fung University of North Texas Cornell University Louis Ramos University of Rochester Jan Brink George Kunz University of California, Los Angeles Poonam Jha University of Michigan University of Michigan Alvie C. Richardson University of Nevada, Reno William Buxton Siavash Kurdistani Emory University Kenneth Jung Harvard University Saint Louis University Neha Sangwan State University of New York, Buffalo Julie Bynum Timothy Kuwada Johns Hopkins University Meryem Koker University of Connecticut University of Michigan Christopher Skidmore Saint Louis University School of Medicine Kimberly Carter Alpa Laheri Baylor College of Medicine Naveendra Korivi Johns Hopkins University University of North Texas Hans Stohrer University of Rochester Annie Chen Timothy Lewis Cornell University School of Medicine Susan Krieg Wayne State University University of Pittsburgh Andrew Sword University of Michigan Francis Coyle Hallie Lightdale University of Connecticut Vidya Krishnan Mount Sinai Medical Center University of Michigan Manoj Thakker Mount Sinai School of Medicine Cynthia Dechenes Jerry Lin University of Rochester Dave Lee Harvard Medical School Saint Louis University Jessica Ulbrich University of Michigan Sophie Deng Elizabeth Lindenberger University of Rochester William Lew Stanford University University of Michigan Jason Van Ittersum University of Michigan Cynthia Dennison Shaden Marzouk Saint Louis University School of Medicine Kristina Liaugaudas Saint Louis University Saint Louis University Seamus Walsh Ohio University College of Medicine Roni Devlin Maritess Mauricio University of Colorado Moe Lim Stanford University Harvard Medical School Crispin Webb University of South Dakota Elaine DiCostanzo Lisa McAllister Mount Sinai School of Medicine Kenneth Lin Ohio University College of Medicine Case Western Reserve University Carlos Weiss University of Michigan Vamil Divan R. Steven Meadows State University of New York, Buffalo Heather Liszka Wake Forest University School of Medicine University of Pittsburgh Michael Widlansky University of Michigan Jesse Eisler Ellen Marie Mongan Mount Sinai School of Medicine Karen Ludlow Columbia University New York Medical College Timothy Willingham Mayo Clinic Frederick Faust Anna Monias Case Western Reserve David Mandel Mount Sinai School of Medicine Medical College of Ohio Flora Yao Loma Linda University Sara Fischer Brian Mulhall University of South Dakota Kimberly Mark Saint Louis University University of South Dakota Tamara Fong Christopher Ng Ohio State University College of Medicine Jill Mhyre University of California, Los Angeles University of Michigan Anne Galbraith Philip Nivatpumin University of Utah University of California, Los Angeles 36 Ghadir Oloumi Jesse Eisler Thomas Murray Mount Sinai School of Medicine Mount Sinai School of Medicine University of Connecticut

Elizabeth Rashley William Garner Jeff Odiet University of South Carolina New York Medical College Harvard Medical School

Katherine Shiue Ceri Hadda Medda Rauhut Washington University Mount Sinai School of Medicine Baylor College of Medicine

Crystal Simpson Argye Hillis Samantha Segal University of Texas Health Science Center at Johns Hopkins University University of Connecticut San Antonio Mwango Kashoki Lydia Shajenko Nitin Soorya Johns Hopkins University University of Connecticut Saint Louis University Hai Kenney Jeffrey Suchniak Jeanne Thompson Ohio University College of Medicine Bowman Gray School of Medicine at Wake University of Pittsburgh Forest University Sally Lee Raymond Thornton University of North Texas Joyce Tang University of Pittsburgh Stanford University Moshe Lewis Thao Truong Mount Sinai School of Medicine Susan Thomas Harvard University Texas A&M University Mehran Mandegar Frances Valdes University of Rochester Chris Tsuneishi Johns Hopkins University Chicago Medical School R. Steven Meadows Brinda Vora Wake Forest University Cordelia Uddoh Jefferson Medical College University of Pennsylvania Marc Mendes Neal Waechter George Washington University Kimberly Vesco University of Michigan University of California, San Diego Lisa Moran Herschel Wallen Saint Louis University Richard Wong University of Michigan New York University Medical Center Christine Murphy Kathleen Walsh University of Minnesota Rhonda Yantiss University of Des Moines College of Harvard Medical School Osteopathic Medicine

Katie Ward Saint Louis University

Paul Wise Johns Hopkins University AFAR-Ohio Affiliate Medical Students Danielle Woodall State University of New York, Buffalo

Edward Yian University of Michigan Christine Hung Marcia Zuckerman 2005 Scholars Case Western Reserve University Harvard University Jeremy Broadnax Alexander Larson 1994 Scholars Case Western Reserve University Ohio State University College of Medicine Mita Deoras Preetinder Brar Ovidiu Marina Northeastern Ohio Universities College of Case Western Reserve University Harvard University Medicine Eric McLoney Julie Bynum Paul Gunn Johns Hopkins University Ohio State University College of Medicine & Case Western Reserve University Public Health Kimberly Cingle Maxwell Hill Case Western Reserve University Leland Metheny University of Cincinnati College of Medicine Case Western Reserve University Judith Cymerman Jessica Holmes University of Southern California Jeanie Wang Case Western Reserve University Northeastern Ohio Universities Laura B. Dunn Evan Howe University of California, San Francisco Aimee Wing Case Western Reserve University Case Western Reserve University 37 AFAR/ISOA Program for Drug Discovery AFAR/Hartford Gero-Physician-Scientist in Cognitive Decline and Alzheimer’s Disease Training Program

One-to two-year awards provided support for innovative drug discovery This fellowship program aimed to develop a cadre of physician-scientists projects by junior faculty (M.D.’s and Ph.D.’s) interested in a career in qualified to teach and do research in their fields of specialization as they drug discovery in Alzheimer’s disease and related dementias. Sponsored relate to the treatment of the elderly, and to establish a knowledge base by the Institute for the Study of Aging. This program was active from to enhance medical student, resident and fellowship training in these 2000 to 2001. disciplines. This program was active from 1992 to 1993.

2001 Recipients 2000 Recipient 1993 Fellows in 1992 Fellows in

Beth Tyler-McMahon, Ph.D. Jack T. Rogers, Ph.D. Geriatric Gynecology Anesthesiology Mayo Clinic, Jacksonville Harvard Medical School Peptide Nucleic Acids Targeted to the A New Translation Regulatory Target in the Lauren Nathan, M.D. G. Alec Rooke, M.D., Ph.D. Amyloid Precursor Protein Alzheimer’s APP Transcript University of California, Los Angeles University of Washington School of Medicine

Yanming Wang, Ph.D. Carmen Sultana, M.D. Randall M. Schell, M.D. University of Pittsburgh Medical Center University MacDonald Womens Hospital/ Duke University Medical Center Amyloid Probes in Aging and Alzheimer’s Case Western Reserve University Disease: Dual Agents for Both PET and SPECT M. Chrystie Timmons, M.D. Duke University Medical Center

AFAR/The Foundation for Fighting Blindness Joint Program for Career Development Awards in Support of Research on Age-Related Macular Degeneration

One-to two-year awards created for junior investigators to facilitate advances in laboratory and clinical research, enhance the understanding of the etiology and pathogenesis of age-related macular degeneration, and develop innovative strategies to prevent, treat or cure this blinding disease.

2001 Recipients

Deborah A. Ferrington, Ph.D. Vassiliki Poulaki, M.D. University of Minnesota Massachusetts Eye and Ear Infirmary Proteomics of Modified Retinal Proteins Mechanisms of Neovascularizationin Age- with Aging Related Macular Degeneration

38 AFAR Milestones

1981 1988 1996 1998

I Irving S. Wright, M.D., gathers aging I AFAR holds first grantee conference, I AFAR launches four-part media brief- I The John A. Hartford Foundation and research leaders at the annual meeting of bringing scientists together to share ing series on older women’s health with AFAR create the Academic Fellowship the American College of Physicians in information, discuss research and create support from the Bristol-Myers Squibb Program in Geriatric Medicine and New Orleans and founds AFAR. opportunities for future cooperation. Foundation. Geriatric Psychiatry.

I AFAR develops a website, 1982 1991 www.afar.org. 1999

I The first AFAR Research Grants are I The John A. Hartford Foundation funds 1997 I Pfizer Inc joins with AFAR to create the awarded. new Gero-Physician-Scientist Training Pfizer/AFAR Research Grant Program. Program to provide physicians in various I First Irving S. Wright Award given to specialties an opportunity to pursue train- I AFAR launches Dorothy Dillon Eweson Nathan W. Shock, Ph.D. ing and research in geriatric medicine. Lecture Series to educate medical 2000 specialists on advances in aging research within their own fields. 1984 1993 I AFAR and the Institute for the Study of I Diane Nixon names grant in memory Aging create the AFAR/ISOA Program for of her mother, Nan Allen Nixon. Drug Discovery in Cognitive Decline and I First AFAR state affiliate formed in I Hadley Ford is elected Chair of the Alzheimer’s Disease. Ohio. Board of Directors. I The John A. Hartford Foundation funds AFAR to establish a Coordinating Center I The Fan Fox and Leslie R. Samuels for the Hartford Foundation’s Centers of Foundation adds support for local med- 1986 1994 Excellence Initiative. ical students through the AFAR/Samuels Foundation Medical Student Geriatric I AFAR launches Lifelong, a newsletter Scholars Program. I Charles A. Dana AFAR Traveling I AFAR receives $14 million grant from for older patients published in Geriatrics Scholars Program established to encour- The John A. Hartford Foundation, The magazine. I AFAR launches Infoaging.org, a con- age interest in geriatric medicine among Atlantic Philanthropies and The sumer information website. future physicians. Commonwealth Fund to administer the I The Merck Company Foundation and Paul Beeson Physician Faculty Scholars in AFAR create the Merck/AFAR Research I The Starr Foundation joins the team of Aging Research Program, the nation’s Scholarships in Geriatric Pharmacology. Beeson Program sponsors. 1987 largest non-governmental award program in academic geriatrics and aging I First “Friends of AFAR” dinner is held research. in New York City. 2001 I George E. Doty is elected Chair of the Board of Directors. I AFAR and The John A. Hartford I AFAR goes global with the first Foundation collaborate to start the International Conference on Biomedical I AFAR and the Glenn Foundation for I The Merck Company Foundation spon- Hartford/AFAR Medical Student Geriatric Aspects of Aging Research held in Venice, Medical Research create awards program sors new fellowships in geriatric clinical Scholars Program. Italy. for post-doctoral fellows. pharmacology. I The Glenn Foundation for Medical I Sponsors of the Paul Beeson I Foundation for Fighting Blindness and Research funds new Glenn/AFAR Student Physician Faculty Scholars in Aging AFAR establish a joint program for career Scholarship Program for Research in the Program commit additional $14 million to development awards in support of Biology of Aging. fund 31 new Scholars. research on age-related macular degen- eration. I Annual AFAR Research Grants top $1 million.

39 2002 2004 2005 2006

I AFAR receives funding from the Merck I Diana Jacobs Kalman elected Chair of I The Glenn Foundation and AFAR I The Julie Martin Mid-Career Award in Company Foundation with a matching the Board of Directors. collaborate to create the Glenn/AFAR Aging Research is created by the Ellison grant from the Glenn Foundation for Breakthroughs in Gerontology (BIG) Medical Foundation. Medical Research to co-fund a segment I AFAR launches southeast affiliate at Award. of the Science of Aging Knowledge Emory University in Atlanta, GA. I The Fannie E. Rippel Foundation Environment (SAGE-KE) project. I AFAR, The John A. Hartford Foundation establishes the Fannie E. Rippel I AFAR celebrates the 10th anniversary and other foundations partner with the Foundation/AFAR New Investigator I The William Randolph Hearst of the Beeson Program with the added NIA on the Medical Student Geriatric Awards on Gender Differences in Foundation contributes to the AFAR support of the National Institute on Aging Program, renamed the Medical Student Cardiovascular Disease in Older Adults. Research Grant Program. and the new name of the Paul B. Beeson Summer Research Training in Aging Career Development Awards in Aging Program. Foundations include The Research. William Randolph Hearst Foundation, The 2003 Cleveland Foundation, Cardinal Health I The Pfizer/AFAR Innovations in Aging Foundation, Lillian R. Gleitsman Research Award is created. Foundation, Community Health I AFAR launches upstate affiliate pro- Foundation of Western & Central New gram in Rochester, NY, funded by the I The William Randolph Hearst York, The New York Community Trust and Starr Foundation. Foundation adds support to the Medical an anonymous donor. Student Geriatric Scholars Program. I The Ellison Medical Foundation and I The Novartis Foundation joins with AFAR team up to support senior post-doc- I Terrapin Society created. AFAR to establish the Aging Well toral fellows. Initiative.

I AFAR and the Merck Institute on Aging and Health create HealthCompass.org.

40 Letter from the Executive Director ...... 1 Major Supporters of the 2005 Grant Programs Celebrating 2005 Selection Committees ...... 2 The AFAR Board of Directors AFAR Research Grant ...... 6 A Quarter Century Anonymous Donor AFAR Affiliate Research Grant ...... 16 The Atlantic Philanthropies of Research AFAR/Glenn Breakthroughs in Gerontology (BIG) Award ....16 The Bedminster Fund Cardinal Health Foundation AFAR/Pfizer Innovations in Aging Research Award ...... 16 The Clarence and Anne Dillon Dunwalke Trust AFAR/Pfizer Research Grant ...... 17 The Cleveland Foundation Paul Beeson Career Development Award Community Health Foundation of Western & Central New York in Aging Research ...... 17 Eisai Inc AFAR/Merck Junior Investigator Award in Geriatric Clinical Pharmacology...... 20 The Ellison Medical Foundation Lillian R. Gleitsman Foundation The American Federation for Aging Research (AFAR) is a nonprofit organization AFAR/Ellison Medical Foundation Senior Postdoctoral Fellows ...... 20 The Glenn Foundation for Medical Research whose mission is to support biomedical research on aging. We fulfill this mission by: AFAR/Glenn Research Grant for Postdoctoral Fellows ...... 21 The Partners of Goldman Sachs & Company The John A. Hartford Foundation AFAR/Merck Research Scholarship in Geriatric ® Supporting biomedical research that furthers our understanding of the Pharmacology for Medical and Pharmacy Students ...... 21 William Randolph Hearst Foundation aging process and its associated diseases and disorders; Diana J. and C. A. Kalman ® Offering opportunities for scientists and physicians to exchange new ideas AFAR/Glenn Scholarship for Research and knowledge about aging; in the Biology of Aging ...... 22 F. M. Kirby Foundation, Inc. ® Building a cadre of early career scientists in aging research and in the AFAR/The John A. Hartford Foundation Academic Fellowship Merck Company Foundation practice of geriatric medicine; and Program in Geriatric Medicine and Geriatric Psychiatry ....27 National Institute on Aging ® Promoting awareness among the general public about the importance of aging research. Medical Student Summer Research The New York Community Trust Training in Aging Program ...... 29 Diane Nixon Since 1981, AFAR has awarded nearly $87 million to more than 2,100 early to AFAR-Ohio Medical Student Summer Research Training in Pfizer Inc mid-career investigators and students, with the goal of encouraging more of Aging Program ...... 37 The Richard and Hinda Rosenthal Foundation the nation’s scientists and physicians to enter and stay in the fields of AFAR/ISOA Program for Drug Discovery in Cognitive Decline gerontology and geriatric medicine. These scientists are conducting cutting- and Alzheimer’s Disease ...... 38 Joseph L. K. Snyder Trust edge research on aging and age-related diseases, such as Alzheimer’s, cancer, The Starr Foundation osteoporosis, diabetes and heart disease. Support for AFAR grants comes from AFAR/The Foundation for Fighting Blindness Joint Program for Career Development Awards in Support of Research on The Irving S. Wright Endowment the generous contributions of corporations, foundations and individuals. Age-Related Macular Degeneration ...... 38 For more information about AFAR, please visit our organizational website, www.afar.org. For more information about aging research and staying healthy AFAR/Hartford Gero-Physician-Scientist as you age, please visit our consumer websites, www.Infoaging.org and Training Program ...... 38 www.HealthCompass.org. AFAR Milestones...... 39 70 West 40th Street 11th Floor New York, NY 10018

AFAR Grant Recipients — 1981-2005