DOCSLIB.ORG

(12) United States Patent (10) Patent No.: US 7.923,221 B1 Cabilly Et Al

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
(12) United States Patent (10) Patent No.: US 7.923,221 B1 Cabilly Et Al US007.923221B1 (12) United States Patent (10) Patent No.: US 7.923,221 B1 Cabilly et al. (45) Date of Patent: *Apr. 12, 2011 (54) METHODS OF MAKING ANTIBODY HEAVY 4,512.922 A 4, 1985 Jones et al. AND LIGHT CHAINS HAVING SPECIFICITY 4,518,584 A 5, 1985 Mark 4,565,785 A 1/1986 Gilbert et al. FORADESIRED ANTIGEN 4,599,197 A 7, 1986 Wetzel 4,634,665 A 1/1987 Axel et al. (75) Inventors: Shmuel Cabilly, Monrovia, CA (US); 4,642,334 A 2f1987 Moore et al. Herbert L. Heyneker, Burlingame, CA 4,668,629 A 5/1987 Kaplan 4,704,362 A 11/1987 Itakura et al. (US); William E. Holmes, Pacifica, CA 4,713,339 A 12/1987 Levinson et al. (US); Arthur D. Riggs, LaVerne, CA 4,766,075 A 8, 1988 Goeddeletal. (US); Ronald B. Wetzel, San Francisco, 4,792.447 A 12/1988 Uhr et al. CA (US) 4,816,397 A * 3/1989 Boss et al. ...................... 435/68 4,816,567 A 3/1989 Cabilly et al. (73) Assignees: Genentech, Inc, South San Francisco, 4,965,196 A 10, 1990 Levinson et al. 5,081,235 A 1/1992 Shively et al. CA (US); City of Hope, Duarte, CA 5,098,833. A 3/1992 Lasky et al. (US) 5,116,964 A 5/1992 Capon et al. 5,137,721 A 8, 1992 Dallas (*) Notice: Subject to any disclaimer, the term of this 5,149,636 A 9, 1992 Axel et al. patent is extended or adjusted under 35 5,179,017 A 1/1993 Axel et al. 5,225,538 A 7/1993 Capon et al. U.S.C. 154(b) by 0 days. 5,225,539 A 7, 1993 Winter This patent is Subject to a terminal dis 5,336,603 A 8/1994 Capon et al. claimer. 5,420,020 A 5/1995 Riggs 5,428, 130 A 6/1995 Capon et al. 5,455,165 A 10/1995 Capon et al. (21) Appl. No.: 08/422,187 5,500,362 A 3, 1996 Robinson et al. 5,514,582 A 5/1996 Capon et al. (22) Filed: Apr. 13, 1995 5,545.403 A 8/1996 Page 5,545.404 A 8/1996 Page Related U.S. Application Data (Continued) (63) Continuation of application No. 07/205,419, filed on Jun. 10, 1988, now Pat. No. 6,331415, which is a FOREIGN PATENT DOCUMENTS continuation of application No. 06/483,457, filed on AU 194982 2, 1983 Apr. 8, 1983, now Pat. No. 4,816,567. (Continued) (51) Int. C. OTHER PUBLICATIONS CI2N 5/3 (2006.01) Gillis, S.D. & J.S. Wesolowski 1990 Hum. Antibod. Hybridomas CI2N IS/00 (2006.01) 1(1): 47-54.* CI2N 15/63 (2006.01) Owens, R.J. & R.J. Young 1994 Journal of Immunological Methods (52) U.S. Cl. ................. 435/69.6; 435/252.1; 435/252.3: 168:149-165. 435/252.33:435/254.11: 435/254.21: 435/69.1; Skerra et al 1988 Science 240: 1038-1041. 435/69.7:435/70.1; 435/70.21; 435/71.1; Better et al. 1989 Methods Enzymol 178: 476-496.* 435/320.1; 435/455; 435/483; 435/485; 435/.440; Taylor et al 1988 Mol Cell Biol 8(10): 4197-4203.* 435/.433; 435/438 Letherbarrow 1985 Midec. Immuno (22(4): 407-415.* Field of Classification Search ................. 435/69.6, Raghunathan et al 1996 Prog. Biophy. &Mol. Biol. 65(5): 143.* (58) Wright et al 1991 EMBOJ, 10(10): 2717-2723.* 435/69.1, 325, 252.3: 530/387.3 Buchner et al 1991 Bio/Technology 9:157-162.* See application file for complete search history. Morrison etal Adv. Immunol. (1989).* Horowitz et al. PNAS, (1988).* (56) References Cited Skerrs etal Protein Engineering, (1991).* U.S. PATENT DOCUMENTS (Continued) 4,179,337 A 12, 1979 Davis 4,224.404 A 9, 1980 Viza et al. Primary Examiner — Phillip Gambel 4,237,224 A 12/1980 Cohen (74) Attorney, Agent, or Firm — Sidley Austin LLP 4.338,397 A 7, 1982 Gilbert 4,342,832 A 8, 1982 Goeddeletal. (57) ABSTRACT 4,348,376 A 9/1982 Goldenberg 4,366,246 A 12/1982 Riggs The invention relates to processes for producing an immuno 4,370,417 A 1/1983 Hung globulin or an immunologically functional immunoglobulin 4,399.216 A 8, 1983 Axel et al. 4,403,036 A 9/1983 Hartley fragment containing at least the variable domains of the 4.418,149 A 11, 1983 Ptashine et al. immunoglobulin heavy and light chains. The processes can 4.419,446 A 12/1983 Howley et al. use one or more vectors which produce both the heavy and 4,431,740 A 2f1984 Bell et al. light chains or fragments thereof in a single cell. The inven 4,440,859 A 4, 1984 Rutter et al. 4,444,878 A 4, 1984 Paulus et al. tion also relates to the vectors used to produce the immuno 4.495,280 A 1/1985 Bujard et al. globulin or fragment, and to cells transformed with the vec 4,500,637 A 2/1985 Neville, Jr. et al. tOrS. 4,510,244. A 4, 1985 Parks et al. 4,511,502 A 4, 1985 Builder et al. 47 Claims, 19 Drawing Sheets US 7.923,221 B1 Page 2 U.S. PATENT DOCUMENTS WO WO 83,00164 1, 1983 5,545.405 A 8/1996 Page WO WO 86.01533 3, 1986 WO WO 87,02671 5, 1987 5,561,053 A 10/1996 Crowley WO WO 89.00999 2, 1989 5,583,013 A 12/1996 Itakura et al. WO WO 89.01783 3, 1989 5,585,089 A 12/1996 Queen et al. WO WO92, 16553 10, 1992 5,605,689 A 2f1997 Ammann WO WO93,07899 4f1993 5,612, 185 A 3, 1997 Uhr et al. WO WO93/10817 6, 1993 5,648,237 A 7, 1997 Carter WO WO93/21319 10, 1993 5,686,072 A 11, 1997 Uhr et al. WO 94.29351 ck 12/1994 5,721, 108 A 2f1998 Robinson et al. WO WO97,30087 8, 1997 5,736,137 A 4, 1998 Anderson et al. ZA 8809711 6, 1988 5,807,715 A 9, 1998 Morrison et al. 5,840,545 A 11/1998 Moore et al. OTHER PUBLICATIONS 5,846,818 A 12, 1998 Robinson et al. “Immunoglobulin molecules and genes' Microbiology Including 5,877,293 A 3, 1999 Adair et al. Immunology and Molecular Genetics, Third edition, Harper Interna 5,997.8675,965,405 A 10,12/1999 1999 WaldmannWinter et al. et al. tionalional EditionEditi vol.1. ChapterCh 1738.379.17:338-379 6,054,297 A 4/2000 Carter et al. Accola et al., “Monoclonal antibodies specific for carcinoembryonic 6,054,561 A 4/2000 Ring antigen and produced by two hybrid cell lines' Proc. Natl. Acad. Sci. 6,120,767 A 9/2000 Robinson et al. USA 77(1):563-566 (1980). 6,204,023 B1 3, 2001 Robinson et al. Adams et al., “Molecular cloning of mouse immunoglobulin heavy 6,331.415 B1* 12/2001 Cabilly et al. chain messenger ribonucleic acids coding for u, O. Y1, Y2a, and Y3 6,455,275 B1 9/2002 Axel et al. chains’ Biochemistry 19:2711-2719 (1980). 6,548,640 B1 4/2003 Winter Amster et al., “Synthesis of part of a mouse immunoglobulin light 6,979,556 B2 12/2005 Simmons et al. chain in a bacterial clone” Nucl. Acids Res. 8(10):2055-2065 (1980). FOREIGN PATENT DOCUMENTS Boss and Emtage, “Expression of an immunoglobulin light chain gene in Escherichia coli' Gene Expression—Proc. Cetus-UCLA AU 12417/83 9, 1983 Symposium pp. 513-522 (Mar. 26, 1983). AU B-26429.8446556/85 10,3, 19841986 Boss and Wood, “Genetically& 8 engineered antibodies'1- . .%d Immunology AU 65981/86 5, 1987 Today 6 (1): 12-13 (1985). EP 37723 10, 1981 Colman and Morser, “Export of proteins from oocytes of Xenopus EP O37723 10, 1981 laevis’ Cell 17:517-526 (1979). EP O41313 12/1981 Colman et al., “Interactions of mouse immunoglobulin chains within EP 41313 12/1981 Xenopus oocytes 'J. Mol. Biol. 160:459-474 (1982). EP 41767 12/1981 & 8 EP O41767 12/1981 Cowan et al., “Intracellular immunoglobulin chain synthesis in non EP O44722 1, 1982 Secreting variants of a mouse myeloma: detection of inactive light EP 55945 7, 1982 chain messenger RNA'.J. Mol. Biol. 90:691-701 (1974). EP 57 107 8, 1982 De Boer et al., “Construction of a tandem trp-lac promoter and a EP O571O7 8, 1982 hybrid trp-lac promoter for efficient and controlled expression of the EP 060057 9, 1982 human growth hormone gene in Escherichia coli' Promoters, Struc EP 068763 1, 1983 ture and Function (Praeger Publishers, R. Rodriguez and M. EP 68763 1, 1983 Chamberline, eds.) pp. 462-481 (1982). EP O73656 3, 1983 Deacon and Ebringer, Antibody synthesis in Xenopus oocytes with EP T3656 3, 1983 messenger ribonucleic acid from immunized rats’ Biochem. Society EP T5444 3, 1983 Transactions 4(4):818-820 (1976). EP A-0736.56O75444 3, 1983 Dolby et al., &"Cloning 8 and partial nucleotide sequence of human EP 88994 9, 1983 immunoglobulin u chain cDNA from B cells and mouse-human EP O93619 11, 1983 hybridomas” Proc. Natl. Acad. Sci. USA 77(10):6027-6031 (1980). EP 102634 3, 1984 Eisen, "Antibody Structure: The immunoglobulins' Immunology, An EP O 120 694 10, 1984 Introduction to Molecular and Cellular Principles of the Immune EP 120694 10, 1984 Responses, Second edition, Harper & Row, Publishers, Inc.
Load more

Recommended publications
  • How the Techniques of Molecular Biology Are Developed from Natural Systems
    How the techniques of molecular biology are developed from natural systems Isobel Ronai [email protected] School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW, Australia. Abstract A striking characteristic of the highly successful techniques in molecular biology is that they are derived from natural systems. RNA interference (RNAi), for example, utilises a mechanism that evolved in eukaryotes to destroy foreign nucleic acid. Other examples include restriction enzymes, the polymerase chain reaction, green fluorescent protein and CRISPR-Cas. I propose that biologists exploit natural molecular mechanisms for their effectors’ (protein or nucleic acid) activity and biological specificity (protein or nucleic acid can cause precise reactions). I also show that the developmental trajectory of novel techniques in molecular biology, such as RNAi, is four characteristic phases. The first phase is discovery of a biological phenomenon, typically as curiosity driven research. The second is identification of the mechanism’s trigger(s), the effector and biological specificity. The third is the application of the technique. The final phase is the maturation and refinement of the molecular biology technique. The development of new molecular biology techniques from nature is crucial for biological research. These techniques transform scientific knowledge and generate new knowledge. Keywords: mechanism; experiment; specificity; scientific practice; PCR; GFP. 1 Introduction Molecular biology is principally concerned with explaining the complex molecular phenomena underlying living processes by identifying the mechanisms that produce such processes (Tabery et al. 2015). In order to access the causal structure of molecular mechanisms it is generally necessary to manipulate the components of the mechanism and to observe the resulting effects with sophisticated molecular techniques.
    [Show full text]
  • Were Ancestral Proteins Less Specific?
    bioRxiv preprint doi: https://doi.org/10.1101/2020.05.27.120261; this version posted May 30, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-ND 4.0 International license. Were ancestral proteins less specific? 1 1,2,3 1,2* Lucas C. Wheeler and Michael J. Harms 2 1. Institute of Molecular Biology, University of Oregon, Eugene OR 97403 3 2. Department of Chemistry and Biochemistry, University of Oregon, Eugene OR 97403 4 3. Department of Ecology and Evolutionary Biology, University of Colorado, Boulder 5 CO 80309 6 7 1 bioRxiv preprint doi: https://doi.org/10.1101/2020.05.27.120261; this version posted May 30, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-ND 4.0 International license. Abstract 8 Some have hypothesized that ancestral proteins were, on average, less specific than their 9 descendants. If true, this would provide a universal axis along which to organize protein 10 evolution and suggests that reconstructed ancestral proteins may be uniquely powerful tools 11 for protein engineering. Ancestral sequence reconstruction studies are one line of evidence 12 used to support this hypothesis. Previously, we performed such a study, investigating the 13 evolution of peptide binding specificity for the paralogs S100A5 and S100A6.
    [Show full text]
  • Species Delimitation in Sea Anemones (Anthozoa: Actiniaria): from Traditional Taxonomy to Integrative Approaches
    Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 10 November 2019 doi:10.20944/preprints201911.0118.v1 Paper presented at the 2nd Latin American Symposium of Cnidarians (XVIII COLACMAR) Species delimitation in sea anemones (Anthozoa: Actiniaria): From traditional taxonomy to integrative approaches Carlos A. Spano1, Cristian B. Canales-Aguirre2,3, Selim S. Musleh3,4, Vreni Häussermann5,6, Daniel Gomez-Uchida3,4 1 Ecotecnos S. A., Limache 3405, Of 31, Edificio Reitz, Viña del Mar, Chile 2 Centro i~mar, Universidad de Los Lagos, Camino a Chinquihue km. 6, Puerto Montt, Chile 3 Genomics in Ecology, Evolution, and Conservation Laboratory, Facultad de Ciencias Naturales y Oceanográficas, Universidad de Concepción, P.O. Box 160-C, Concepción, Chile. 4 Nucleo Milenio de Salmonidos Invasores (INVASAL), Concepción, Chile 5 Huinay Scientific Field Station, P.O. Box 462, Puerto Montt, Chile 6 Escuela de Ciencias del Mar, Pontificia Universidad Católica de Valparaíso, Avda. Brasil 2950, Valparaíso, Chile Abstract The present review provides an in-depth look into the complex topic of delimiting species in sea anemones. For most part of history this has been based on a small number of variable anatomic traits, many of which are used indistinctly across multiple taxonomic ranks. Early attempts to classify this group succeeded to comprise much of the diversity known to date, yet numerous taxa were mostly characterized by the lack of features rather than synapomorphies. Of the total number of species names within Actiniaria, about 77% are currently considered valid and more than half of them have several synonyms. Besides the nominal problem caused by large intraspecific variations and ambiguously described characters, genetic studies show that morphological convergences are also widespread among molecular phylogenies.
    [Show full text]
  • Introduction: the Powers of Association
    Copyrighted Material CHAPTER ONE Introduction: The Powers of Association In the summer of 2000, as the rainy season started, I made my way to the poor Dakar suburb of Th iaroye to meet a family with multiple cases of sickle cell anemia. Th ere were no paved sidewalks and my shoes sank in the mud when I jumped off the rusty minibus in a line of other hurried passengers. Stray sewer water bubbled from an opening in the street, creating small puddles of grey that were now being abluted by the downpour. Mr. Seck, the man I had come to see, had his niece keep watch for me, “the American from the hospital.” She surveyed me like sport as I divided my attention between the faulty gutters and locating the house. When we entered the compound, Seck welcomed me with a hard handshake. Th e whole family joined around, every­ one extending an arm, to introduce themselves with the familiarity and cheer an American usually reserves for a loved one. Doctors in town had recently diagnosed two of Seck’s children, ages eight and twelve, with HbSC sickle cell anemia, a less serious, heterozygous form of the more common homozygous HbSS disease. Both forms of the illness pro­ duce the hallmark symptom of this hemoglobin disorder: the vascular pain of arterial vessels clogged with sticky, damaged red blood cells, commonly called “the sickle cell crisis.” Th e children were prescribed folic acid for fi ft een days a month and Doliprane, the local name of acetaminophen, for pain when needed.
    [Show full text]
  • Electronic Version2
    TAIWANESE IDENTITY AND LANGUAGE EDUCATION The Role of Race, Ethnicity, Language, Culture and Nation in the Colonization of Taiwan A Thesis Submitted to the College of Graduate Studies and Research In Partial Fulfilment of the Requirements for the Degree of Master of Education In the Department of Education Foundations College of Education University of Saskatchewan Saskatoon By Edmond G. Tetrault Copyright Edmond G. Tetrault July 2003 All Rights Reserved PERMISSION TO USE In presenting this thesis in partial fulfilment of the requirements for a post-graduate degree at the University of Saskatchewan I agree that the Libraries of this University may make it freely available for inspection. I further agree that permission for the copying of this thesis in any manner, in whole or in part, for scholarly purposes may be granted by the professor or professors who supervised my thesis work, or, in their absence, by the Head of the Department or Dean of the College in which my thesis work was done. It is understood that any copying or use of this thesis or parts thereof for financial gain shall not be allowed without my written permission. It is also understood that due recognition shall be given to me and to the University of Saskatchewan in any scholarly use of which may be made of any material in my thesis. Requests for permission to copy or make other use of material in this thesis should be addressed to: Head of the Department of Education Foundations College of Education University of Saskatchewan S7N 0W0 ii ABSTRACT In this thesis I look at the question of Taiwanese identity by focussing on characteristics that have come to be considered natural human identity attributes worldwide.
    [Show full text]
  • History of Genetics Book Collection Catalogue
    History of Genetics Book Collection Catalogue Below is a list of the History of Genetics Book Collection held at the John Innes Centre, Norwich, UK. For all enquires please contact Mike Ambrose [email protected] +44(0)1603 450630 Collection List Symposium der Deutschen Gesellschaft fur Hygiene und Mikrobiologie Stuttgart Gustav Fischer 1978 A69516944 BOOK-HG HG œ.00 15/10/1996 5th international congress on tropical agriculture 28-31 July 1930 Brussels Imprimerie Industrielle et Finangiere 1930 A6645004483 œ.00 30/3/1994 7th International Chromosome Conference Oxford Oxford 1980 A32887511 BOOK-HG HG œ.00 20/2/1991 7th International Chromosome Conference Oxford Oxford 1980 A44688257 BOOK-HG HG œ.00 26/6/1992 17th international agricultural congress 1937 1937 A6646004482 œ.00 30/3/1994 19th century science a selection of original texts 155111165910402 œ14.95 13/2/2001 150 years of the State Nikitsky Botanical Garden bollection of scientific papers. vol.37 Moscow "Kolos" 1964 A41781244 BOOK-HG HG œ.00 15/10/1996 Haldane John Burdon Sanderson 1892-1964 A banned broadcast and other essays London Chatto and Windus 1946 A10697655 BOOK-HG HG œ.00 15/10/1996 Matsuura Hajime A bibliographical monograph on plant genetics (genic analysis) 1900-1929 Sapporo Hokkaido Imperial University 1933 A47059786 BOOK-HG HG œ.00 15/10/1996 Hoppe Alfred John A bibliography of the writings of Samuel Butler (author of "erewhon") and of writings about him with some letters from Samuel Butler to the Rev. F. G. Fleay, now first published London The Bookman's Journal
    [Show full text]
  • Motivations, Practice, and Conflict in the History of Nuclear Transplantation, 1925-1970
    A 'Fantastical' Experiment: Motivations, Practice, and Conflict in the History of Nuclear Transplantation, 1925-1970 A DISSERTATION SUBMITTED TO THE FACULTY OF THE GRADUATE SCHOOL OF THE UNIVERSITY OF MINNESOTA BY Nathan Paul Crowe IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY Mark Borrello, Adviser December, 2011 © Nathan Paul Crowe 2011 All Rights Reserved Acknowledgements Though completing a dissertation is often seen as a solitary venture, the truth is rather different. Without the help of family, friends, colleagues, librarians, and archivists, I would never have been able to finish my first year in graduate school, let alone my thesis. During the course of my research I came in contact with many people who were invaluable to my eventual success. First and foremost are those librarians, archivists, and collections specialists who helped guide me through a sea of records. I am indebted to all of those who helped me in the process: in particular, I would like to thank Janice Goldblum and Daniel Barbiero at the National Academy of Sciences, Lee Hiltzik at the Rockefeller Archives Center, and National Cancer Institute Librarian Judy Grosberg. At the National Institutes of Health, librarian Barbara Harkins, information specialist Richard Mandel, and historian David Cantor were all extremely useful in helping me find what I needed. I also can't imagine anyone being more accommodating than librarian Beth Lewis and her staff at the Fox Chase Cancer Center Library. I was able to complete my research with the financial support of several institutions. My thanks go out to the Rockefeller Archive Center for their generous help.
    [Show full text]
  • Molecular Dissection of the Functional Specificity of Glycophosphatidylinositol Anchors
    Molecular dissection of the functional specificity of glycophosphatidylinositol anchors By Thomas B. Nicholson Department of Biochemistry McGill University, Montreal September 2007 A thesis submitted to McGill University in partial fulfillment of the requirements of the degree of Doctor of Philosophy © Thomas B. Nicholson 2007 Thesis Abstract Carcinoembryonic antigen (CEA) is a cell surface protein attached to the membrane by a glycophosphatidylinositol (GPI) anchor, a common modification of cell surface proteins. CEA is overexpressed in many human cancers, and plays a role in tumor progression through its ability to activate certain integrins, thereby blocking cellular differentiation, inhibiting anoikis, and disrupting normal tissue architecture. Previous work established that the CEA GPI anchor contains important and specific information directing these functions, which served as the basis for an investigation of the underlying mechanisms involved. The ability of the GPI anchor to determine protein function was examined using a chimera that consisted of the CEA GPI anchor attached to neural cell adhesion molecule (NCAM) self-adhesive external domains; this chimera, NCB, possessed CEA-like, rather than NCAM-like, functions. The CEA anchor targets the protein to specific domains on the cell surface, resulting in an association with specific signaling molecules. This targeting was employed to modify CEA function, as the presence of a protein with non-functional external domains but the same anchor led to a complete and specific loss of biological function of the CEA-like protein. GPI anchor addition is determined by a specific carboxy-terminal signal sequence, which we hypothesized contained information directing the addition of a particular GPI anchor with functional specificity.
    [Show full text]
  • First European Advanced Seminar in the Philosophy of the Life Sciences
    First European Advanced Seminar in the Philosophy of the Life Sciences Causation and Disease in the Postgenomic Era PROGRAM and ABSTRACTS © 2009, Olivier Filippi (http://o.filippi.fr/) Hosted by the Brocher Foundation Hermance (Geneva), Switzerland, September 6 - 11, 2010 Monday, September 6 13:30 Welcome 14:00 Giovanni BONIOLO (Milano), Could mechanisms and the philosophy of cartoon biology vanish? Marco NATHAN (New York), Comment Discussion 15:30 Break 16:00 Jean GAYON (Paris), Function, Disease and Overcapacity: Causation in a non-normal world Miles MACLEOD (Altenberg), Comment Discussion 18:30 Optional concert at Eglise St Germain Maurice STEGER and the Ensemble LA CIACCONA Misic baroque for ‘flûte à bec’ Tuesday, September 7: BOUNDARIES 09:00 Hillel BRAUDE (Montreal), Linking Pain and Pathos: Revisiting the Causal Problematic in Clinical Medicine through Affective Neuroscience Lara Katharina KUTSCHENKO (Mainz), Why Classify Diseases? 10:30 Break 11:00 Paolo MAUGERI (Milan) and Alessandro BLASIMME (Milan), Modelling Cancer and the Problem of Disanalogy Thomas PRADEU (Paris), Comment Discussion 12 :30 Lunch 14:00 John DUPRE (Exeter), Emerging Sciences and New Conceptions of Disease Francesca MERLIN (Montreal and Paris), Comment Discussion 15:30 Break 16:00 Lisa GANNETT (Halifax), Context Matters: A Local Epistemology of “Race” Kathryn TABB (Pittsburgh), Comment Discussion Wednesday, September 8: CAUSATION 09:00 Pierre-Olivier METHOT (Exeter and Paris), From the ‘Law of Declining Virulence’ to the ‘Trade-off Model’: Using Historical
    [Show full text]
  • Forms and Functions : Life-Anatomy Or Physiology?
    Portland State University PDXScholar University Honors Theses University Honors College 2014 Forms and Functions : Life-Anatomy or Physiology? Theresa Payne Portland State University Follow this and additional works at: https://pdxscholar.library.pdx.edu/honorstheses Let us know how access to this document benefits ou.y Recommended Citation Payne, Theresa, "Forms and Functions : Life-Anatomy or Physiology?" (2014). University Honors Theses. Paper 103. https://doi.org/10.15760/honors.96 This Thesis is brought to you for free and open access. It has been accepted for inclusion in University Honors Theses by an authorized administrator of PDXScholar. Please contact us if we can make this document more accessible: [email protected]. Forms and Functions: Life-Anatomy or Physiology by Theresa Payne An undergraduate honors thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Science in University Honors and Philosophy Thesis Adviser Tom Seppalainen Portland State University 2014 1 | P ay n e Forms and Functions: Life-Anatomy or Physiology? Explicit Definition: To maintain consistency and coherence of thought within this text all uses of the term “form” should be taken as; “Shape, arrangement of parts, visible aspect (esp. apart from colour).” 1 This connotation of form is only to be understood as outward appearance or constitution of material entities. In no way is form to be taken in the Aristotelian, Platonic, or any philosophical sense; but as an aggregate of parts in functional relation to the environment. Any use of the term ‘form’ in quoted texts that does not reflect this usage will be changed by the author to essence, and will be annotated with an * and referenced in the footnotes.
    [Show full text]
  • Predictability and the Unpredictable Life, Evolution and Behaviour
    Filosofia e saperi – 10 Sconfinamenti tra i saperi umanistici e le scienze della vita Crossing borders between the humanities and the life sciences Collana dell’Istituto per la storia del pensiero filosofico e scientifico moderno (ISPF) del Consiglio Nazionale delle Ricerche Book series of the Institute for the History of Philosophy and Science in Modern Age, National Research Council, Italy Diretta da / Editors Silvia Caianiello, ISPF, CNR, Italy Maria Conforti, University of Rome La Sapienza Manuela Sanna, ISPF, CNR, Italy The book series “Filosofia e saperi”, active from 2009, has renewed in 2016 its scientific mission, adding the subtitle “Sconfinamenti tra i saperi umanistici e le scienze della vita / Crossing borders between the humanities and the life sciences”, enlarging its Scientific Committee and accepting texts also in English and in the other major European lan- guages. Its scope is to promote research committed to a dynamical representation of the relationship between human sciences and life sciences and practices, and to stimulate new theoretical perspectives capable of supporting the communication and interaction between different disciplinary fields and thought styles. The research fields addressed by the book series are: • history and philosophy of the life sciences • bioethics • history of scientific concepts and metaphors • public understanding of life sciences • social and political history of life sciences • history of scientific collections and useumsm • art and life sciences iconography • scientific practices and sites of knowledge production in life sciences Contact for submissions: [email protected] Copyright © MMXVIII CNR Edizioni www.edizioni.cnr.it [email protected] P.le Aldo Moro 7 00185 Roma ISBN 978 88 8080 236 5 I diritti di traduzione, di memorizzazione elettronica, di riproduzione e di adattamento anche parziale, con qualsiasi mezzo, sono riservati per tutti i paesi Non sono assolutamente consentite fotocopie senza permesso scritto dell’Editore I edizione: novembre 2018 Stampa Arti Grafiche Bruno - T.
    [Show full text]
  • Bitten by the Biology Bug. Monograph VI. Essays From
    DOCUMENT RESUME ED 338 483 SE 052 209 AUTHOR Flannery, Maura C. TITLE Bitten By The Blology Bug. Monograph VI. Essays from "The American Biology Teacher." INSTITUTION National Association of Biology Teachers, Washington, D.C. REPORT NO ISBN-0-941212-08-4 PUB DATE 91 NOTE 120p. AVAILABLE FROM National Association of Biology Teachers, 11250 Roger Bacon Dr. #19, Reston, VA 22090. PUB TYPE Viewpoints (Opinion/Position Papers, Essays, etc.) (120) EDRS PRICE MF01 Plus Postage. PC Not Available from EDRS. DESCRIPTORS *Biology; Books; Career Choice; Communications; Entomology; *Essays; Human Body; Plants (Botany); Science Instruction; Secondary Education ABSTRACT A collection of 18 essays originally published in "The American Biology Teacher" in a column headed "Biology Today" are presented. The essays have been reprinted in chronological order and begin with an essay published in March 1982. A variety of types of writings were selected: some focus on teaching biology, othe:s on the science itself. Several deal with books and articles that have excited and interested the columnist over the years. The following essays are included: (1) "Books and Biology";(2) "Turning Teaching Around";(3) "Naturalists"; (4) "The Importance of Trivia"; (5) "Broadening Our Horizons"; (6) "Branching Out"; (7) "Things I'd Never Thought About"; (8) "Bitten by the Insect Bug"; (9) "Beginning Again"; (10) "Who Could Have Guessed It?" (11) "The Other Side of the Coin"; (12) "In the Flower Garden"; (13) "Of Chaperones and Dancing Molecules: The Power of Metaphors"; (14) "Commmicating Biology"; (15) "Eye on Biology"; (16) "Loving Biology--It's About Time"; (17) "Human Biology"; and (,18) "Telling About the Lure of Science." Most chapters include references.
    [Show full text]