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LWMS Spring 2006 email: [email protected] web: www.lwms.ac.uk SPRING 2006 A look at activities in and around the Leicester Warwick Medical Schools Inside Issue 12... Leicester General Hospital Centenary Dr Hugh Mackay (retired consul- tant histopathologist) has written an extensive history of LGH, enti- tled The Palace on the Hill, which Unique tribute to his patients. is due to be published shortly and p3 Research findings presented to will be available in all LGH wards those who had taken part and departments. Below he gives a brief outline of some of the hospital’s highlights. Leicester General Hospital recently celebrated the centenary of its opening on 28th September 1905. Built in open country with 16 wards on 2 storeys off a straight central corridor, (at 194 yards long one of the longest in the country) it Patient Safety Awareness. replaced the overcrowded work- p5 New course greeted with enthusiasm house infirmary near the London Road railway station. Its grand appearance earned the nickname of “The Palace on the Hill”. There was strict discipline and NHS on 5th July 1948. Little LGH by Prof Sir Peter Bell in 1975. segregation of males in wards 1-8 changed as basic medical knowl- Minimal Access Surgery Training, and females in wards 9-16 named edge and treatments were still very diabetes care, geriatric medicine after Leicester’s municipal wards. limited. Specialist orthopaedics and gastroenterology have all flour- There were no operating theatres or and the hospital school (one of the ished while two of our surgeons are out-patient facilities. Very basic first in the country) began in 1932. national lead-clinicians for cancer care for 512 patients was provided The start of the Leicester Medical care. Students’ eye view. Elective p6-7 in Egypt, plus MedSin by 3 medical officers, one non-resi- School in 1974 saw new medical, LGH became an NHS Trust in achievements dent, and 40 nurses including 8 surgical and maternity wards 1993 and with the Leicester Royal ward sisters. opening, plus purpose-built oper- Infirmary and Glenfield formed the During the First World War, the ating theatres and out-patient University Hospitals of Leicester army took over the hospital and space. Several Foundation Profes- NHS Trust in April 2000. Major with a temporary base in the old sors were based at LGH until the reconfiguration plans across County Lunatic Asylum (now the Medical Sciences and Clinical Leicester will see almost complete Fielding Johnson Building, part of Sciences Buildings were finished. re-building of LGH to become a the University), treated 74,625 Since then, LGH has built an planned care, and rehabilitation wounded servicemen. international reputation for centre plus the main focus for inter- The Poor Laws ended in 1930 nephrology, renal transplantation professional education and training and Leicester City Council assumed and urology services. Leicester’s in Leicester. p8 Dean’s Dozen avenges last responsibility until the start of the first renal transplant was done at “Semper ad suprema” year’s defeat. Leicester Warwick Medical Schools News Spring 2006 2 Leicester Warwick Medical Schools News focus Spring 2006 RESEARCH Professor Bryan Williams, tance of clinical research.” Professor of Medicine in the Depart- The ASCOT Study is a randomised ment of Cardiovascular Sciences at trial of prevention of coronary heart Leicester, broke new ground when disease and other vascular events by he took the unusual step of inviting blood pressure and cholesterol all 423 Leicester patients who had lowering. The trial involved a wide participated in a major research range of patients aged between 40 study to two meetings to present the and 80 years old, all of whom had research findings. high blood pressure and a combina- In September he explained to tion of other risk factors which cause packed halls in Leicester and Market heart disease, such as smoking and Harborough how these patients’ co- diabetes. operation in the ASCOT Study Check-ups were routine and (Anglo Scandinavian Cardiac typical of those that any patient Outcomes Trial) will have a major would have at their usual clinic visit. effect on the way doctors treat blood There were two treatment groups: pressure and other risk factors in the one treated with a calcium channel UK. blocker and the other with a beta- In doing so, Professor Williams paid tribute to them for the part they had played. “To my knowledge, this Major International is the first time the results of a major study have been presented to the patients in the study,” he said. “This Research Trial Acknowledges will allow them to see how exciting clinical research is and how impor- tant their participation has been in Patients’ Input changing clinical practice in the blocker. Some patients in each diuretic bendroflumenthiazide-K) early March. The CAFÉ study United Kingdom. I see this as a very group were also treated with a statin treatment regimens and their blood showed important differences in important opportunity to present the to lower blood cholesterol. pressure was monitored using the central aortic pressure with different work of the University and the NHS They returned for check-ups after traditional arm cuff measurements. blood pressure treatments, possibly locally to the wider community. six weeks, three months and six The ASCOT study showed that explaining the difference in cardio- “The results of this study are likely months to ensure their blood pres- patients receiving the amlodipine- vascular outcomes observed in to impact directly on national guide- sure was well controlled. After that based treatment did better than ASCOT. lines. Leicester has played a very they visited the centre every six those getting the atenolol-based Professor Williams said: “These significant role and I think this is months. treatment on all cardiovascular studies indicate the huge impor- going to present a very powerful ASCOT is one of the largest endpoints, including a 24% reduc- tance of clinical research. The fact image of the importance of the inter- studies of high blood pressure ever tion in cardiovascular death. that they have been conducted in action between the NHS and clinical conducted in Europe, involving A sub-study of the ASCOT trial, Leicester means that our patients research in Leicester and result in nearly 20,000 patients with high CAFÉ (Conduit Artery Function Eval- are benefiting from the rapid transfer change and improvements in the blood pressure and additional risk uation) was designed and co-ordi- of new knowledge into the clinical health service. factors for heart disease and stroke. nated from Leicester. This study was arena. It was gratifying to see how “This has not been done before in Patients were randomised to recently presented by Prof Williams much the patients enjoyed hearing Leicester, but I think it could be the receive either calcium channel at the late breaking Clinical Trials about how their contribution to clin- first of a series of important initia- blocker-based (amlodipine + the “hotline” session at the American ical research in Leicester will directly tives to better engage the general ace inhibitor perindopril) or beta Heart Association in Dallas, sched- impact on the treatment of many public in understanding the impor- blocker based (atenolol + the uled to be published in Circulation in millions of patients world-wide.” Warwick Clinical Trials Unit New Research 'Will Change Way Heart Attack Patients Warwick Clinical Trials Unit is a Professor Janet Dunn, who will new unit within Warwick Medical lead a programme of cancer are Treated' School. Directed by Professor trials. Twenty full-time staff cover Sallie Lamb, the Unit has partic- the full range of roles required for A recently published study led vessel. The British Heart Founda- ular expertise in clinical trials of running high quality clinical trials from the University of Leicester tion-funded research, published in – clinical trialists, statisticians, complex interventions and is and University Hospitals of the New England Journal of Medi- leading several multi-centre project managers, research Leicester NHS Trust reveals that cine, will change the way heart randomised controlled trials with fellows and clinicians. You can angioplasty can cut the risk of attack patients are treated - patients recruited from across the find out more about the unit and adverse outcome by half for UK. Its major focus is on trials of its work on thewebsite: patients suffering a heart attack, making angioplasty to reopen a emergency care and rehabilitation, www.warwick.ac.uk/go/ctu. where conventional clot-busting clogged artery the standard of care and it has recently been joined by drugs have failed to open the if clot-busting drugs have failed. 3 news Leicester Warwick Medical Schools News CURRICULUM Spring 2006 and drinks in the BioMed Grid whilst been trained to support the BioMed they study, either alone or in groups, Grid, which is staffed at all times. It The BioMed Grid and the noise level is self managed is open between 10am and 10pm On 20th February the new BioMed provide a new kind of study space to by the users. Monday to Friday and between Grid opened in the Medical School facilitate student-centred learning The BioMed Grid provides a refer- 12pm and 9pm on Sunday. Building at Warwick. Funded by the and encourage groups of students to ence stock of core texts for the MB Future developments will include University using HEFCE Project learn together. The BioMed Grid ChB programme, wireless network the addition of careers materials and Capital, the development is a extends this provision to support access, a small number of networked careers advice, to be provided by the response to student feedback, students on the Gibbet Hill campus. PC workstations, an internet kiosk new Medical School Careers calling for improved study facilities A number of different zones within and areas of desking for individual Advisor, and in the summer the on the Gibbet Hill campus.
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