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Cover Page.Pub Harvard University Program in Neuroscience Faculty Directory 2018 - 2019 January 1, 2019 Program in Neuroscience Faculty Albers, Mark (MGH-East)) Datta, Bob (HMS/Neurobio) Kaeser, Pascal (HMS/Neurobio) Regehr, Wade (HMS/Neurobio) Andermann, Mark (BIDMC) De Bivort, Benjamin (Harvard/OEB) Kaplan, Joshua (MGH/HMS/Neurobio) Ressler, Kerry (McLean) Anderson, Matthew (BIDMC) Dettmer, Ulf (BWH) Karmacharya, Rakesh (MGH) Rogulja, Dragana (HMS/Neurobio) Anthony, Todd (BCH/Neurobio) Do, Michael (BCH—Neurobio) Khurana, Vikram (BWH) Rosenberg, Paul (BCH/Neurology) Arlotta, Paola (Harvard/SCRB) Dong, Min (BCH) Kim, Kwang-Soo (McLean) Sabatini, Bernardo (HMS/Neurobio) Assad, John (HMS/Neurobio) Drugowitsch, Jan (HMS/Neurobio) Kocsis, Bernat (BIDMC) Sahay, Amar (MGH) Bacskai, Brian (MGH/East) Dulac, Catherine (Harvard/MCB) Kreiman, Gabriel (BCH/Neurobio) Sahin, Mustafa (BCH/Neurobio) Baker, Justin (McLean) Dymecki, Susan(HMS/Genetics) LaVoie, Matthew (BWH) Samuel, Aravi (Harvard/ Physics) Bean, Bruce (HMS/Neurobio) Engert, Florian (Harvard/MCB) Lee, Wei-Chung (BCH/Neurobio) Sanes, Joshua (Harvard/MCB) Bellono, Nicholas (Harvard/MCB) Engle, Elizabeth(BCH/Neurobio) Lehtinen, Maria (BCH/Pathology) Saper, Clifford (BIDMC) Benowitz, Larry (BCH/Neurobio) Fagiolini, Michela (BCH/Neurobio) Liberles, Steve (HMS/Cell Biology) Scammell, Thomas (BIDMC) Berretta, Sabina (McLean) Feany, Mel (HMS/Pathology) Lichtman, Jeff (Harvard/MCB) Scherzer, Clemens (BWH) Bolshakov, Vadim (McLean) Fishell, Gord (HMS/Neurobio & Broad) Lipton, Jonathan (BCH/Neurobio) Schwarz, Tom (BCH/HMS—Neurobio) Born, Richard (HMS/Neurobio) Flanagan, John (HMS/Cell Biology) Livingstone, Marge (HMS/Neurobio) Segal, Rosalind (DFCI/HMS—Neurobio) Breakefield, Xandra (MGH—East) Gaab, Nadine (BCH/Pediatrics) Loeken, Mary (Joslin Diabetes Center) Selkoe, Dennis (BWH) Brown, Emery (MGH) Gaudet, Rachelle (Harvard/MCB) Lowell, Brad (BIDMC) Shah, Khalid (MGH) Buckholtz, Joshua (Harvard/Psych) Geleoc, Gwenaelle (BCH/Neurobio) Lu, Kun Ping (BIDMC) Shen, Jie (HMS/Neurology) Buckner, Randy (Harvard UPsych) Gershman, Sam (Harvard/Psych) Ma, Qiufu (DFCI/HMS/Neurobio) Simonyan, Kristina (MEEI) Caine, S. Barak (McLean) Ginty, David (HMS/Neurobio) Macklis, Jeffrey (Harvard/SCRB) Smirnakis, Stelios (BWH) Carlezon, William (McLean) Goodrich, Lisa (HMS/Neurobio) Macosko, Evan (Broad Institute) Stevens, Beth (BCH—Neurobio) Cepko, Constance (HMS/Genetics) Gray, Jesse (HMS/Genetics) Majzoub, Joseph (BCH/Pediatrics) Tanzi, Rudolph (MGH—East) Chartoff, Elena (McLean) Greenberg, Michael (HMS/Neurobio) Masland, Richard (MEEI) Uchida, Naoshige (Harvard/MCB) Chen, Chinfei (BCH/Neurobio) Greka, Anna (MGH) McCarroll, Steven (HMS/Genetics) Umemori, Hisashi (BCH—Neurobio) Chen, Dong Feng (Schepens) Gu, Chenghua (HMS/Neurobio) Megason, Sean (HMS/Systems Bio) Wainger, Brian (MGH-East) Chen, Zheng-Yi (MEEI) Harvey, Chris (HMS/Neurobio) Murthy, Venkatesh (Harvard/MCB) Walsh, Christopher (BCH/Neurobio) Chiu, Isaac (HMS/Microbiology) Harwell, Corey (HMS/Neurobio) Navarro, Victor (BWH) Weitz, Charles (HMS—Neurobio) Cohen, Adam (Harvard/Chemistry) He, Zhigang (BCH—Neurobio) Nelson, Charles (BCH/Pediatrics) Williams, Ziv (MGH) Cohen, Jonathan (HMS/Neurobio) Heiman, Maxwell (BCH/Genetics) Ölveczky, Bence (Harvard/OEB) Wilson, Rachel (HMS/Neurobio) Commons, Kathryn (BCH) Holt, Jeffrey (BCH/Neurobio) Orefice, Lauren (MGH) Woolf, Clifford (BCH—Neurobio) Corey, David (HMS/Neurobio) Huh, Jun (HMS/Microbiology) Pecot, Matthew (HMS/Neurobio) Yankner, Bruce (HMS/Genetics) Crickmore, Mike (BCH/Neurobio) Hyman, Bradley (MGH—East) Pizzagalli, Diego (McLean) Yellen, Gary (HMS/Neurobio) Czeisler, Charles (BWH) Indzhykulian, Artur (MEEI) Polley, Daniel (MEEI) Yuan, Junying (HMS/Cell Biology) Isaacson, Ole (McLean) Disclaimer Please note that in the following descripons of faculty members, only students from the Program in Neuroscience are listed. You cannot assume that if no students are listed, it is a small or inacve lab. Many faculty members are very acve in other programs such as Biological and Biomedical Sciences, Molecular and Cellular Biology, etc. If you find you are interested in the descripon of a lab’s research, you should contact the faculty member (or go to the lab’s website) to find out how big the lab is, how many graduate students are doing there thesis work there, etc. Mark Albers, M.D./Ph.D. Joined 2012 Assistant Professor of Neurology Massachusetts General Hospital Institute for Neurodegenerative Disease 114 16th Street, No. 2003 Charlestown [email protected] The goal of the research in the Albers lab is to elucidate the pathogenic actions and physiological functions of genes and mechanisms that cause neurodegenerative disease and develop novel diagnostic and therapeutic approaches. Our principal hypothesis is that these genes and mechanisms conspire with the biology of aging to confer vulnerability to neurons by disrupting the integrity of neurons and neural circuits. The questions addressed by these studies intersect with fundamental questions in neuroscience, including how are connections in the nervous system modified by experience, how is the genome in neurons altered by aging, and how is the communication across these connections contribute to the propagation of neuronal death within neural circuits. We address these issues in the peripheral olfactory neural circuit of the mouse and human, a circuit that is evolutionarily conserved. The mouse circuit is genetically tractable, and the human circuit is vulnerable to neurodegenerative disease. We combine novel mouse models that express pathogenic and normal isoforms of the human amyloid precursor protein solely in a subset of olfactory neurons with multiphoton in vivo imaging, fluorescence activated cell sorting, deep sequencing, and other basic techniques of investigation. Examination of these lines has revealed a novel mechanism of propagated neurodegeneration within a neural circuit that is amenable to FDA approved drugs. We have recapitulated this mechanism in vitro and have applied systems approaches to elucidate the mechanisms and screen for drugs. In addition, we have conducted a CRISPR-Cas9 genome-wide screen to identify new targets that provide surprising insights to Alzheimer’s and ALS pathogenesis. These laboratory approaches are complemented by parallel informatics, in silico drug trial in electronic health records, and clinical research with the ultimate goal of personalized clinical trials in patients with clear evidence of pathogenic mechanisms. PiN thesis students: [none] PiN rotation students: [none] PiN PEC memberships: [none] PiN DAC memberships: Narendra Joshi PiN defense [none] committees: Mark Andermann, Ph.D. Joined 2012 Associate Professor of Medicine Beth Israel Deaconess Medical Center Center for Life Sciences, room 701 3 Blackfan Circle Boston [email protected] The goal of my lab is to understand the role of corticolimbic areas in guiding attention to, and imagery, learning and memory of, motivationallysalient external and interoceptive stimuli. To understand these neural phenomena at the level of local microcircuitry, we developed a paradigm for chronic two-photon calcium imaging of visual responses in identified neurons and axonal boutons in thalamus, cortex and amygdala of mice performing visual discrimination tasks or running on a trackball. In collaboration with Dr. Brad Lowell at BIDMC, we are pursuing imaging and behavioral studies of attention to motivationally salient sensory stimuli (e.g. food vs. non-food stimuli) using natural manipulations of motivational states (e.g. hunger and satiety; Burgess, Ramesh et al., Neuron 2016; Ramesh, Burgess et al., Neuron 2018), together with optetrode and photometry recordings and photostimulation of specific hypothalamic neurons that drive ingestive behaviors (e.g. Garfield et al., Nature Neurosci. 2016; Mandelblat -Cerf et al., eLife, 2015; Mandelblat-Cerf et al., Neuron, 2017). Our goal is to implicitly toggle amongst motivational drives states (via rapid activation of genetically-defined hypothalamic cell types that drive different hunger, thirst, salt-appetite), and assess biases in neural processing of motivationally-relevant cues. We then use these genetic entry points to track the pathways to cortex that ultimately assign value to neural representations of motivationally-relevant cues (e.g. Livneh et al., Nature, 2017). In related work, we are examining offline cortical reactivation of motivationally salient cue representations during quiet waking and its impact on circuit connectivity (Sugden et al., in revision). In collaboration with Dr. Chinfei Chen at Boston Children’s Hospital, we recently elucidated new rules governing convergence of visual information streams from retina to thalamus (Liang et al., Cell, 2018). In future, we hope to build on this work understand how primary sensory and interoceptive inputs are selectively modulated by motivational state. PiN thesis students: Kelly McGuire; Jasmine Reggiani; Nick Jikomes (‘11—’16); Rohan Ramesh (‘12 - ‘18) PiN rotation students: David Brann; Yurika Doi; Michelle Frank; Chong Guo; Stephen Holtz; Minsuk Hyun; Robert Johnson; Angela Kim; Matthew McGill; Kelly McGuire; Alexandra Moore; Julia Nguyen; Jasmine Reggiani; Slater Sharp; Hugo Vega-Ramirez; Nick Jikomes; Matthias Minderer; Rohan Ramesh PiN PEC memberships: Peter Angeli; David Brann; Cesar Echavarria; Michelle Frank; Winthrop Gillis; Allison Hamilos; Stephen Holtz; Lingfeng Hou; Kee Wui Huang; Jay Lee; Suk Joon Lee; Julia Nguyen; Noah Pettit; Shih-Yi Tseng;
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