Ackrell Capital Cannabis Investment Report
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Formulation and Evaluation of Transdermal Patch and Gel of Nateglinide
Human Journals Research Article September 2015 Vol.:4, Issue:2 © All rights are reserved by C. Aparna et al. Formulation and Evaluation of Transdermal Patch and Gel of Nateglinide Keywords: Nateglinide, transdermal patch and gel, HPMC, ethyl cellulose, carbopol, PVA, PVP ABSTRACT Anusha Gundeti, C. Aparna*, Dr. Prathima Srinivas The objective of the present work was to formulate Transdermal Drug Delivery systems of Nateglinide, an Department of Pharmaceutics, Sri Venkateshwara antidiabetic drug belonging to meglitinide class with a half life of 1.5 hrs. Transdermal patches containing nateglinide were College of Pharmacy, prepared by solvent casting method using the combinations Affiliated to Osmania University, of HPMC:EC, PVA:PVP, HPMC:Eudragit RS 100, Eudragit RL100:RS100 in different proportions and by incorporating Madhapur, Hyderabad, Telangana -500081, India. different permeation enhancers (polyethylene glycol 400, Su bmission: 7 September 2015 DMSO). The transdermal patches were evaluated for their physicochemical properties like thickness, weight variation, Accepted: 11 September 2015 folding endurance, percentage moisture absorption, percentage Published: 25 September 2015 moisture loss, in-vitro diffusion studies & ex-vivo permeation studies. Transdermal Gel was formulated using HPMC, carbopol 934, carbopol 940 and methyl cellulose. Gels were evaluated for homogeneity, pH, viscosity, drug content, in-vitro diffusion studies & ex-vivo permeation studies. By comparing the drug release F5 (HPMC:EC) formulation was selected as optimized formulation as it could sustain the drug release for 12 hrs i.e. 99.2% when compared to gel. Stability studies were www.ijppr.humanjournals.com carried out according to ICH guidelines and the patches maintained integrity and good physicochemical properties during the study period. -
Cannabis Basics – Glossary of Terms
6/18/2019 Cannabis Basics - Glossary of Terms • Emerald Family Farms EMERALD FAMILY FARMS CANNABIIS BASIICS Cannabis Basics – Glossary of Terms POSTED ON AUGUST 9,, 2018 BY ADMIIN Whether you're a seasoned cannabis connoisseur or just discovering what the world of cannabis has to offer. Battery A rechargeable battery used for heating up a vaporizing cannabis concentrate cartridge. Vape Batteries come in lots of styles and it is important to have one that will heat your cartridge at a proper temperature. Blunt A blunt is a cannabis joint wrapped in tobacco instead of a rolling paper. Created by either dumping out the tobacco of a store-bought cigar then reusing the tobacco wrap for crafting a cannabis joint or crafted using a pre-made blunt wrap. https://www.emeraldfamilyfarms.com/cannabis-basics-glossary/ 1/10 6/18/2019 Cannabis Basics - Glossary of Terms • Emerald Family Farms BHO Butane Hash Oil BHO, butane hash oil is made by pressure blasting cannabis owers with butane. The butane solvent causes THC to become soluble, resulting in a butane/THC mixture. Once the butane is evaporated, depending upon the starting material, apparatus used, and techniques applied during the process, the resulting concentrate product is a viscous and amber colored resin in the form of “sauce,” “crumble,” “wax,” or “shatter.” Bubble Hash A non-solvent based extraction method that utilizes ice-cold temperatures and micron screens to collect trichomes. Called Bubble Hash for its full melt qualities that cause the product to bubble and melt when exposed to ame. Cannabidiol Also known as CBD, is one of at least 113 different cannabinoids found in cannabis. -
What Type of Cannabis Therapy Is Best for You?
What to Look For CANNABIS OIL EXTRACTS ü CBD-rich products. Choose products that can be taken orally, sublingually or include both CBD, a non-intoxicating applied topically. Concentrated compound, and THC, the main psychoactive What Type of cannabis oil extracts can also be component of cannabis. CBD and THC work utilized as an ingredient to vaporize or best together, enhancing each other's Cannabis cook with. Some cannabis oils come therapeutic benefits. with an applicator for measured ü dosing. These oil extracts—CBD-rich Clear labels. Look for product labels Therapy Is showing the quantity and ratio of CBD and and THC-dominant—are very potent. THC per dose, a manufacturing date and The time of onset and duration of batch number (for quality control). Best for You? effect vary depending on the method of administration. ü Lab testing. Look for products that are tested for consistency, and verified as free of mold, bacteria, pesticides, solvent residues, and other contaminants. ü Quality ingredients. Select products with Visit ProjectCBD.org for: quality ingredients. (No corn syrup, GMOs, transfats, preservatives, and artificial CBD Locator • Educational resources additives.) • Dispensary staff training • Updates ü Safe extraction. Avoid products extracted on cannabis science & therapeutics • with toxic solvents like BHO, propane, hexane CBD-rich product list • Analysis of or other hydrocarbons. Solvent residues are industry trends • Events • especially dangerous for immune- Announcements • Referrals compromised patients. Look for products that entail a safer method of extraction like supercritical CO2. Advancing whole plant ü Products made from organic cannabis not industrial hemp. Compared to high resin cannabis therapeutics cannabis, hemp is typically low in cannabinoid content. -
Cannabis (Sub)Culture, the Subcultural Repository, and Networked Mediation
SIMULATED SESSIONS: CANNABIS (SUB)CULTURE, THE SUBCULTURAL REPOSITORY, AND NETWORKED MEDIATION Nathan J. Micinski A Thesis Submitted to the Graduate College of Bowling Green State University in partial fulfillment of the requirements for the degree of MASTER OF ARTS May 2014 Committee: Ellen Berry, Advisor Rob Sloane © 2014 Nathan Micinski All Rights Reserved iii ABSTRACT Ellen Berry, Advisor Subcultural theory is traditionally rooted in notions of social deviance or resistance. The criteria for determining who or what qualifies as subcultures, and the most effective ways to study them, are based on these assumptions. This project seeks to address these traditional modes of studying subcultures and discover ways in which their modification may lead to new understandings and ways of studying subcultures in the contemporary moment. This will be done by suggesting a change in the criteria of examining subcultures from that of deviance or resistance to identification with a collection of images, symbols, rituals, and narratives. The importance of this distinction is the ability to utilize the insights that studying subcultures can offer while avoiding the faults inherent in speaking for or at a subculture rather than with or from it. Beyond addressing theoretical concerns, this thesis aims to apply notions of subcultural theory to study the online community of Reddit, in particular, a subset known as r/trees–a virtual repository for those images, symbols, rituals, and narratives of cannabis subculture. R/trees illustrates the life and vibrancy of a unique subcultural entity, which to this point has evaded a cultural studies analysis. To that end, this project advocates for the importance of the cultural studies approach to analyzing cannabis subculture and further, to insert the findings of this study into that gap in the literature. -
Extracts and Tinctures of Cannabis
WHO Expert Committee on Drug Dependence Critical Review …………….. Extracts and tinctures of cannabis This report contains the views of an international group of experts, and does not necessarily represent the decisions or the stated policy of the World Health Organization © World Health Organization 2018 All rights reserved. This is an advance copy distributed to the participants of the 41st Expert Committee on Drug Dependence, before it has been formally published by the World Health Organization. The document may not be reviewed, abstracted, quoted, reproduced, transmitted, distributed, translated or adapted, in part or in whole, in any form or by any means without the permission of the World Health Organization. The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted and dashed lines on maps represent approximate border lines for which there may not yet be full agreement. The mention of specific companies or of certain manufacturers’ products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters. The World Health Organization does not warrant that the information contained in this publication is complete and correct and shall not be liable for any damages incurred as a result of its use. -
Clearing the Smoke on Cannabis Edible Cannabis Products, Cannabis Extracts and Cannabis Topicals
7 Clearing the Smoke on Cannabis Edible Cannabis Products, Cannabis Extracts and Cannabis Topicals Robert Gabrys, Ph.D., Research and Policy Analyst, CCSA Key Points • Edible cannabis products, cannabis extracts and cannabis topicals have unique health and safety risks that are not inherent to dried cannabis. • High-potency cannabis extracts increase the risk of over-intoxication more This is the seventh in a series of than dried cannabis. Although limited, the available evidence indicates that reports that reviews the effects of frequent use of these products is associated with problematic cannabis use, cannabis use on various aspects of cannabis use disorder and mental health disorders. human functioning and development. • Edible cannabis products can increase the risk of over-consumption and Other reports in this series address subsequent over-intoxication and impairment. Because when unpackaged they look like ordinary food and beverage products, edible cannabis products the link between regular cannabis use also increase the risk of unintentional ingestion, especially by children. and mental health, regular cannabis • Research on cannabis topicals, including the use of topical and transdermal use and cognitive functioning, maternal cannabidiol products, is limited. There is, however, growing interest among cannabis use during pregnancy, dermatologists and consumers in these cannabis products. cannabis use and driving, respiratory • The health impacts associated with long-term use of edible cannabis and cardiovascular effects of smoking products, cannabis extracts and cannabis topicals are not known. cannabis, and the medical use of • Public education efforts will play an important role in mitigating the harms cannabis and cannabinoids. This series associated with new cannabis products. -
Marijuana Myths and Facts: the Truth Behind 10 Popular Misperceptions
MARIJUANA myths & FACTS The Truth Behind 10 Popular Misperceptions OFFICE OF NATIONAL DRUG CONTROL POLICY MARIJUANA myths & FACTS The Truth Behind 10 Popular Misperceptions OFFICE OF NATIONAL DRUG CONTROL POLICY TABLE OF CONTENTS Introduction.............................................................................. 1 Myth #1: Marijuana is harmless .......................................... 3 Myth #2: Marijuana is not addictive ................................... 7 Myth #3: Marijuana is not as harmful to your health as tobacco............................................................. 9 Myth #4: Marijuana makes you mellow............................. 10 Myth #5: Marijuana is used to treat cancer and other diseases...................................................... 11 Myth #6: Marijuana is not as popular as MDMA (Ecstasy) or other drugs among teens today...................... 13 Myth #7: If I buy marijuana, I’m not hurting anyone else......................................................... 14 Myth #8: My kids won’t be exposed to marijuana ............. 17 Myth #9: There’s not much parents can do to stop their kids from experimenting with marijuana ........... 19 Myth #10: The government sends otherwise innocent people to prison for casual marijuana use......... 21 Conclusion .............................................................................. 23 Glossary.................................................................................. 25 References .............................................................................. -
Round Table: Legalized Marijuana
ROUND TABLE Legalized Marijuana June 5 2018 Table of Contents Opening Letter…………………………………………………………………………………………………………………….pg 2 Cannabis Legalization (official release from the Government of Ontario)……………………………..pg 3 Scripture Used to Support Marijuana Use…………………………………………………………………………….pg 7 Scripture Used to Oppose Marijuana Use…………………………………………………………………………….pg 9 The Medical Side of Things………………………………………………………………………………………………..pg 11 When Pot is Legal, What Do We Say?.................................................................................................pg 16 Can Cannabis and Christ Co-exist?.......................................................................................................pg 20 Marijuana to the Glory of God?.............................................................................................................pg 25 Questions to Wrestle Through…………………………………………………………………………………………..pg 29 1 219 Talbot St E Leamington ON N8H 3V6 Tel: 519.326.3605 www.meadowbrook.ca Hello everyone! On Tuesday, June 5th 2018 at 7pm, we will be having a round-table discussion about the legalization of marijuana, which is coming to Canada soon. How do we grapple with this and approach it as Christians, as parents, as a church? We wanted to take some time to get together and talk about the issue. We are not gathering on this night to argue, or to craft an official policy, or to solve the matter once and for all. This will be an ongoing conversation for all of us, requiring prayer and careful thought, and it is likely not going to be -
An Archetype Swing in Transdermal Drug Delivery
Indo American Journal of Pharmaceutical Research, 2017 ISSN NO: 2231-6876 A COMPREHENSIVE REVIEW ON MICRONEEDLES - AN ARCHETYPE SWING IN TRANSDERMAL DRUG DELIVERY G. Ravi*, N. Vishal Gupta, M. P. Gowrav Department of Pharmaceutics, JSS College of Pharmacy, JSS University, Shri Shivarathreeshwara Nagara, Mysuru, Karnataka, India. ARTICLE INFO ABSTRACT Article history Transdermal drug delivery is the non-invasive delivery of medications through the skin Received 23/12/2016 surface into the systemic circulation. The advantage of transdermal drug delivery system is Available online that it is painless technique of administration of drugs. The advantage of transdermal drug 31/01/2017 delivery system is that it is painless technique of administration of drugs. Transdermal drug delivery system can improve the therapeutic efficacy and safety of the drugs because drug Keywords delivered through the skin at a predetermined and controlled rate. Due to the various Microneedles, biomedical benefits, it has attracted many researches. The barrier nature of stratumcorneum Hypodermic Needles, poses a danger to the drug delivery. By using microneedles, a pathway into the human body Transdermal, can be recognized which allow transportation of macromolecular drugs such as insulin or Stratumcorneum, vaccine. These microneedles only penetrate outer layers of the skin, exterior sufficient not to Patch. reach the nerve receptors of the deeper skin. Thus the microneedles supplement is supposed painless and reduces the infection and injuries. Researches from the past few years showed that microneedles have emerged as a novel carrier and considered to be effective for safe and improved delivery of the different drugs. Microneedles development is created a new pathway in the drug delivery field. -
Religious Use of Marijuana Cases
Summaries of Religious Use of Marijuana Cases Alabama regulate was conceivable, only that none had Rheuark v. State (1992) 601 So.2d 135 been proposed. Statutes prohibiting possession of marijuana and controlled substances did not violate freedom of California: religion rights of defendant claiming that he People v. Mullins (1975) 50 Cal. App 3d 61 worshipped plants as gods and used marijuana Facts: A deputy sheriff had gone to defendant's and psilocybin as religious practice. premises at night at the invitation of a man who Court compared Defendant’s argument to a past lived in a teepee on the property and who had told ruling on polygamy and quoting the cases the officer there were marijuana plants growing Reynolds v. United State 98 U.S. 145 and there. The officer took two plants as samples to Cleveland v. United States 329 U.S. 14 which in be tested and, three days later, went back to the sum says that morality is defined by statute and property with a search warrant. Defendant's Congress and not the individual’s perceptions of property is not enclosed or surrounded by a morality. Therefore because the possession of fence. From Ten Mile Creek Road there is a marijuana is unlawful, it doesn’t matter that the driveway that leads onto defendant's property. Defendant used it for religious use. There is no gate at the entrance to the property. At the entrance there is a sign reading “Universal Arizona: Life Church of Christ Light.” Defendant's wife People v. Hardesty (2009) 214 P.3d 1004 testified that on and prior to May 30, 1972, there FACTS: Hardesty was driving his van at night was a “no trespassing” sign at the entrance to the when an officer stopped him because one property; that a church known as “Universal Life headlight was out. -
Cannabis Ordinance Revisions; Amending Berkeley Municipal Code Chapters 12.21, 12.22, 20.40, 23C.25, and Sub-Titles 23E and 23F
Page 1 of 99 Office of the City Manager PUBLIC HEARING January 28, 2020 To: Honorable Mayor and Members of the City Council From: Dee Williams-Ridley, City Manager Submitted by: Timothy Burroughs, Director, Planning and Development Department Subject: Cannabis Ordinance Revisions; Amending Berkeley Municipal Code Chapters 12.21, 12.22, 20.40, 23C.25, and Sub-Titles 23E and 23F RECOMMENDATION Conduct a public hearing and upon conclusion, provide direction regarding proposed ordinance language alternatives and take the following action: Adopt the first reading of five ordinances to amend the Berkeley Municipal Code (BMC) Chapters 12.21, 12.22, 20.40, 23C.25, and Sub-Titles 23E and 23F which would: A. Allow new business types (Delivery-Only Retailers, Consumption Lounges); B. Allow Retailers to continue to operate as Microbusinesses; C. Clarify cannabis business operational standards and development standards, such as quotas and buffers, for Storefront Retailers; D. Allow more opportunities for Commercial Cultivation by expanding location options; and E. Protect the health of the general public and youth with additional advertising, signage and sales regulations. SUMMARY The proposed cannabis ordinances would revise definitions and establish operating standards for new and existing cannabis businesses in Berkeley, and include new regulations based on commission recommendations, Council direction, and Resolution 68,326-N.S., which established Berkeley as a sanctuary city for recreational cannabis use. The new ordinances would fully address new uses (Delivery-Only Retailers, Consumption Lounges and Retail Storefront Microbusinesses1), and modify development standards and signage requirements for existing uses. The proposed ordinances were reviewed by the Cannabis Commission (CC) and the Community Health Commission (CHC). -
Transdermal Nicotine Maintenance Attenuates the Subjective And
Neuropsychopharmacology (2004) 29, 991–1003 & 2004 Nature Publishing Group All rights reserved 0893-133X/04 $25.00 www.neuropsychopharmacology.org Transdermal Nicotine Maintenance Attenuates the Subjective and Reinforcing Effects of Intravenous Nicotine, but not Cocaine or Caffeine, in Cigarette-Smoking Stimulant Abusers 1 1 ,1,2 Bai-Fang X Sobel , Stacey C Sigmon and Roland R Griffiths* 1Department of Psychiatry and Behavioral Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA; 2Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA The effects of transdermal nicotine maintenance on the subjective, reinforcing, and cardiovascular effects of intravenously administered cocaine, caffeine, and nicotine were examined using double-blind procedures in nine volunteers with histories of using tobacco, caffeine, and cocaine. Each participant was exposed to two chronic drug maintenance phases (21 mg/day nicotine transdermal patch and placebo transdermal patch). Within each drug phase, the participant received intravenous injections of placebo, cocaine (15 and 30 mg/70 kg), caffeine (200 and 400 mg/70 kg), and nicotine (1.0 and 2.0 mg/70 kg) in mixed order across days. Subjective and cardiovascular data were collected before and repeatedly after drug or placebo injection. Reinforcing effects were also assessed after each injection with a Drug vs Money Multiple-Choice Form. Intravenous cocaine produced robust dose-related increases in subjective and reinforcing effects; these effects were not altered by nicotine maintenance. Intravenous caffeine produced elevations on several subjective ratings; nicotine maintenance did not affect these ratings. Under the placebo maintenance condition, intravenous nicotine produced robust dose-related subjective effects, with maximal increases similar to the high dose of cocaine; nicotine maintenance significantly decreased the subjective and reinforcing effects of intravenous nicotine.