Lise Meitner (1878–1968)
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The Pedersen Memorial Issue
springer.com Chemistry : Organic Chemistry The Pedersen Memorial Issue Foreword: Charles J. Pedersen (1904-1989), Nobel Laureate in Chemistry (1987) This issue is dedicated to the memory of the late Charles J. Pedersen in recognition of his outstanding contribution to scientific research, culminating in his discovery of crown ethers and their remarkable cation complexing properties and his receipt of the 1987 Nobel Prize in Chemistry. Charlie's origin and early years in Korea did not portend the creative work in chemistry which would characterize his later life. However, we can see in his early years the influence of his Norwegian father and Japanese mother who considered his formal education to be of utmost importance. At the age of eight, he was sent abroad to Japan for schooling, first at a convent school in Nagasaki, and two years later at a French-American preparatory school in Yokohama run by a Marianist order of Catholic priests and brothers. The latter group encouraged him to attend the order's University of Dayton in Ohio where he received a bachelors degree in Springer chemical engineering. Charlie's academic experiences, his employment with du Pont, and the Softcover reprint of the creative spark which he manifested at an early stage of his scientific career are detailed in the 1st original 1st ed. 1992, VI, paper in this issue by Herman Schroeder. Schroeder had a long-time association with Charlie at edition 406 p. du Pont as a co-worker, supervisor, and friend. His recollections provide insight into Charlie's creative mind. In addition, they make it clear that a long period of creative work preceded the accidental discovery of the first synthetic crown ether. -
The Transuranium Elements: from Neptunium and Plutonium to Element 112
UCRL-JC- 124728 The Transuranium Elements: From Neptunium and Plutonium to Element 112 Professor Darleane C. Hoffman Lawrence Livermore National Laboratory G. Seaborg Institute for Transactinium Science RECEIVED T. Isotope Sciences Division sEp23 ?9g6 This paper was prepared for submittal to the Conference Proceedings NATO Advanced Study Institute on "Actinides and the Environment" Chania, Crete, Greece July 7-19, 1996 July 26, 1996 DISCWMER This document was prepared as an account of work sponsored by an agency of the United States Government. Neither the United States Government nor the University of California nor any of their employees, makes any warranty, express or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed, or represents that its use would not infringe privately owned rights. Reference herein to any specific commercial product, process, or service by trade name, trademark, manufacturer, or otherwise, does not necessarily constitute or imply its endorsement, recommendation, or favoring by the United States Government or the University of California. The views and opinions of authors expressed herein do not necessarily state or reflect those of the United States Government or the University of California, and shall not be used for advertising or product endorsement purposes. DISCLAIMER Portions of this document may be illegible in electronic image products. Images are produced from the best avaiiable original document. c THE TRANSURANIUM ELEMENTS: FROM NEPTUNIUM AM) PLUTONIUM TO ELEMENT112 DarIeane C. Hoffman Nuclear Science Division & Chemistry Department, University of California, Berkeley, CA 94720 & G. T. Seaborg Institute for ' Transactinium Science, MS-L23 1, LLNL, Livermore, CA 94550. -
The 2016 Nobel Prize in Chemistry
Pure Appl. Chem. 2016; 88(10-11): 917–918 Editorial Hugh D. Burrows* and Richard M. Hartshorn* The 2016 Nobel Prize in Chemistry DOI 10.1515/pac-2016-2005 Keywords: Ben L. Feringa; Jean-Pierre Sauvage; J. Fraser Stoddart; Nobel Prize in Chemistry; 2016. Pure and Applied Chemistry warmly congratulates Jean-Pierre Sauvage (University of Strasbourg, France), Sir J. Fraser Stoddart (Northwestern University, Evanston, IL, USA), and Bernard (Ben) L. Feringa (Univer- sity of Groningen, the Netherlands) on their award of the 2016 Nobel Prize in Chemistry. The citation from the Royal Swedish Academy of Sciences states that the award is “for the design and synthesis of molecu- lar machines”. Their work encompasses a broad spectrum of Chemistry, from elegant synthetic studies of catenanes, rotaxanes and other formerly considered exotic molecules, through coordination chemistry, and electron transfer reactions, to molecular switches and rotors driven by light and other external sources. They have all participated actively in IUPAC endorsed meetings and conference series, including the IUPAC World Congress in Chemistry, IUPAC International Conferences on Organic Synthesis (ICOS), Physical Organic Chemistry (ICPOC), and Coordination Chemistry (ICCC), and IUPAC International Symposia on Macrocyclic Chemistry (ISMC), Organometallic Chemistry Directed Towards Organic Synthesis (OMCOS), Novel Aromatic Compounds (ISNA), Carbohydrate Chemistry (ICS), the Chemistry of Natural Products ISCNP), and Photo- chemistry. Pure Appl. Chem. publishes collections of papers based upon authoritative lectures presented at such IUPAC endorsed events, in addition to IUPAC Recommendations, and Technical Reports. We are very pleased to highlight the following publications from these three Nobel Laureates that have been published in Pure and Applied Chemistry as a result of their involvement in these conferences. -
The Lock-And-Key Analogy in 20Th Century Biochemistry
From: Rebecca Mertens The Construction of Analogy-Based Research Programs The Lock-and-Key Analogy in 20th Century Biochemistry April 2019, 224 p., pb., ill. 34,99 € (DE), 978-3-8376-4442-5 E-Book: PDF: 34,99 € (DE), ISBN 978-3-8394-4442-9 When the German chemist Emil Fischer presented his lock-and-key hypothesis in 1899, his analogy to describe the molecular relationship between enzymes and substrates quickly gained vast influence and provided future generations of scientists with a tool to investigate the relation between chemical structure and biological specificity. Rebecca Mertens explains the appeal of the lock-and-key analogy by its role in model building and in the construction of long-term, cross-generational research programs. She argues that a crucial feature of these research programs, namely ascertaining the continuity of core ideas and concepts, is provided by a certain way of analogy-based modelling. Rebecca Mertens (PhD), born in 1984, is a postdoctoral researcher in the history and philosophy of science at the University of Bielefeld, Germany. She works on the role of analogies, models and forms of comparison in the history of molecular genetics and is a member of the collaborative research program "Practices of ComparisonÚ Ordering and Changing the World". During her graduate and doctoral studies, she was a visiting scholar at the École Normale Supérieure in Paris and a visiting graduate fellow at the Minnesota Center for Philosophy of Science. For further information: www.transcript-verlag.de/en/978-3-8376-4442-5 © 2019 -
Pauling-Linus.Pdf
NATIONAL ACADEMY OF SCIENCES L I N U S C A R L P A U L I N G 1901—1994 A Biographical Memoir by J A C K D. D UNITZ Any opinions expressed in this memoir are those of the author(s) and do not necessarily reflect the views of the National Academy of Sciences. Biographical Memoir COPYRIGHT 1997 NATIONAL ACADEMIES PRESS WASHINGTON D.C. LINUS CARL PAULING February 28, 1901–August 19, 1994 BY JACK D. DUNITZ INUS CARL PAULING was born in Portland, Oregon, on LFebruary 28, 1901, and died at his ranch at Big Sur, California, on August 19, 1994. In 1922 he married Ava Helen Miller (died 1981), who bore him four children: Linus Carl, Peter Jeffress, Linda Helen (Kamb), and Edward Crellin. Pauling is widely considered the greatest chemist of this century. Most scientists create a niche for themselves, an area where they feel secure, but Pauling had an enormously wide range of scientific interests: quantum mechanics, crys- tallography, mineralogy, structural chemistry, anesthesia, immunology, medicine, evolution. In all these fields and especially in the border regions between them, he saw where the problems lay, and, backed by his speedy assimilation of the essential facts and by his prodigious memory, he made distinctive and decisive contributions. He is best known, perhaps, for his insights into chemical bonding, for the discovery of the principal elements of protein secondary structure, the alpha-helix and the beta-sheet, and for the first identification of a molecular disease (sickle-cell ane- mia), but there are a multitude of other important contri- This biographical memoir was prepared for publication by both The Royal Society of London and the National Academy of Sciences of the United States of America. -
Institute of Physics
Slectron Spectroscopy for Atoms, Molecules and Condensed Matter Nobel Lecture, December 8, 1981 by Kai Siegbahn nstitute of Physics, University of Uppsala, Box 530, S-751 21 Uppsala, Sweden UUIP-1052 December 1981 UPPSALA UNIVERSITY INSTITUTE OF PHYSICS Electron Spectroscopy for Atoms, Molecules and Condensed Matter Nobel Lecture, December 8, 1981 by Kai Siegbahn Institute of Physics, University of Uppsala, Box 530, S-751 21 Uppsala, Sweden UUIP-1052 December 1981 Electron Spectroscopy for Atoms, Molecules and Condensed Matter Nobel Lecture, December 8, 1981 by Kai Siegbahn Institute of Physics University of Uppsala, Sweden In my thesis /I/, which was presented in 1944, I described some work which I had done to study 3 decay and internal conversion in radioactive decay by means of two different principles. One of these was based on the semi-circular focusing of electrons in a homogeneous magnetic field, while the other used a big magnetic lens. The first principle could give good resolution but low intensity, and the other just the reverse. I was then looking for a possibility of combining the two good properties into one instrument. The idea was to shape the previously homogeneous magnetic field in such a way that focusir: should occur in two directions, instead of only one as in + ,• jemi-circular case. It was known that in beta- trons the ,-.•• trons performed oscillatory motions both in the radial anc j the axial directions. By putting the angles of period eq;. ;.. for the two oscillations Nils Svartholm and I /2,3/ four) a simple condition for the magnetic field form required ^ give a real electron optical image i.e. -
Antibodies with Some Bite Antibodies Have Yet to Be Determined, It Is Reasonable to Suppose That the Ester Or David E
-~-------------------------------------N8NSANDVIEWS----------------_N_A_TU_R_E_V-O_L_._32_5_22_J_A_N_U_A_RY__ 19~87 Enzyme catalysis kinetics and is subject to competitive inhibition. Although the detailed chemical mechanisms of these catalytic Antibodies with some bite antibodies have yet to be determined, it is reasonable to suppose that the ester or David E. Hansen carbamate is strained towards a tetra hedral geometry on binding, thus facilitat THE spectacular specificities and rate William Jencks', more directly, stated in ing the attack of the hydroxide ion. Fur enhancements of enzymes are without 1969 thermore, the Scripps group has already equal among all known catalysts. It is no If complementarity between active site and found that their antibody can act via both wonder then that the design of new en transition state contributes significantly to nucleophilic and general base catalysis, zymes has long been a goal of biochemists. enzyme catalysis, it should be possible to syn depending on the substrate used. Now two independent groups, one led by thesize an enzyme by constructing a binding The fact that this approach succeeded at Alfonso Tramontano and Richard Lerner site. One way to do this is to prepare an anti all gives great hope to those attempting to of the Scripps Clinic and Research Foun body to a haptenic group which resembles the isolate even more efficient antibody cat dation', and the other by Peter Schultz of transition state of a given reaction. The com alysts by this and by other strategies. In the University of California at Berkeley\ bining sites of such antibodies should be com addition, it may be possible to modify have taken steps towards this goal by plementary to the transition state and should cause an acceleration by forcing bound sub existing catalytic antibodies. -
Chapter 1 the Biography of a Trafficking Material
Trafficking Materials and Maria Rentetzi Gendered Experimental Practices Chapter 1 The Biography of a Trafficking Material In 1904, an article titled "Radium and Radioactivity" appeared in Century 1 Magazine, a monthly popular magazine published from 1881 to 1930. The article presents Marie Curie's personal account of the discovery of radium and radioactivity. In the article, Curie discusses in depth her arduous attempts to study the radiation of the compounds of uranium and that of known chemical elements, hoping to discover more which are endowed with atomic radioactivity. She revels that it was the chemists who supplied her with the materials she needed. "As I desired to make a very thorough investigation, I had resource to different chemists, who put at my disposal specimens—in some cases the only ones in existence—containing very rare elements." Her next step was to examine different minerals, especially the oxide of uranium 2 ore (pitchblende). To her great surprise, this specimen was found to be four times more active than oxide of uranium itself. The explanation was more than obvious. "The ore must contain a substance more radioactive than uranium and thorium, and this substance must necessarily be a chemical element as yet unknown."1 Her attempts to isolate the new element would lead Marie and Pierre Curie, who joined her research shortly after, to the discovery of both polonium and radium, to the Nobel Prize in Physics in 1903, and to a second Nobel Prize in 1911, this time in chemistry. This chapter attempts to present a cultural -
Origins and Early Years Peace Through Scientific Co-Operation Became an Abiding Purpose
Topical reports: 30th anniversary year The International Atomic Energy Agency: Origins and early years Peace through scientific co-operation became an abiding purpose by Dr John A. Hall Motivated by the apprehension of scientists and' Auspices of the United States Government 1940-1945.* statesmen, created by determined negotiating groups^ This lengthy title/prp'ved too cumbersome for some of and structured to meet thexchallenges of.the future, the the reviewers. The, account,,— prepared by Professor International Atomic Energy Agency celebrates its 30th Henry DeWolf Smyth, Chairman of the Department of birthday on 29 July 1987. • ~\ "' '.. - -">;; •Physics of Princeton University — presented concisely The concept of an international atomic energy organi- in language understandable to the layman, the scientific zation was proposed over 40 years ago. The aims ofsuch background and the nature of atomic energy, and the an organization were to control the new force of nuclear development of the weapon. This small book enjoyed energy for peaceful purposes, to solve the problem of extensive circulation and has been translated into 40 lan- atomic weapon limitation, to protect the public from the guages.** hazards of radiation, and also to promote a constructive dialogue between the United States and the Soviet Union Postwar roots in this new and dynamic field. Following the war, many scientists and statesmen had After the formulation of the early proposals, 10 years concluded that it was vital to secure international control of discussion and fumbling followed, finally resulting in of nuclear energy. The new United Nations, established negotiations leading to the establishment in 1957 of an in the summer of 1945, appeared to be the logical forum autonomous and independent international organization, for examining the possible ways of achieving this goal. -
CV Sir Arthur Harden
Curriculum Vitae Prof. Dr. Arthur Harden Name: Sir Arthur Harden Lebensdaten: 12. Oktober 1865 ‐ 17. Juni 1940 Arthur Harden war ein britischer Chemiker. Nach ihm sind die Harden‐Young‐Ester (Zuckerphospha‐ te) benannt. Für seine Forschungen über die Gärung von Zucker und dessen Gärungsenzyme wurde er im Jahr 1929 gemeinsam mit dem deutsch‐schwedischen Chemiker Hans von Euler‐Chelpin mit dem Nobelpreis für Chemie ausgezeichnet. Werdegang Arthur Harden studierte von 1882 bis 1885 Chemie am Owens College der University of Manchester. 1868 ging er mit einem Dalton Scholarship an die Universität Erlangen, um beim Chemiker Otto Fi‐ scher, einem Vetter von Emil Fischer (Nobelpreis für Chemie 1902), zu arbeiten. Dort wurde er 1888 promoviert. Im Anschluss arbeitete er als Dozent am Owens College. Ab 1897 war er am neu gegrün‐ deten British Jenner Institute of Preventive Medicine tätig. 1907 wurde er dort Leiter der Abteilung Biochemie. Außerdem erhielt er 1912 eine Professur für Biochemie an der University of London. Auch nach seiner Emeritierung im Jahr 1930 blieb Harden wissenschaftlich aktiv. So befasste er sich unter anderem mit dem Stoffwechsel von E.coli‐Bakterien sowie mit der Gärung. Gemeinsam mit dem deutsch‐schwedischen Wissenschaftler Hans von Euler‐Chelpin gelang es ihm, diesen Vorgang vollständig aufzuklären. Nobelpreis für Chemie 1929 Die Aufklärung der Gärung als eine der ältesten biologischen Technologien der Menschheit hatte bereits zuvor viele Wissenschaftler zu Forschungsarbeiten angeregt, unter ihnen Louis Pasteur und Justus Freiherr von Liebig. Arthur Harden wurde für seine Forschungen über die Gärung von Zucker und die daran beteiligten Gärungsenzyme im Jahr 1929 gemeinsam mit Hans von Euler‐Chelpin mit dem Nobelpreis für Chemie ausgezeichnet. -
A Nobel Synthesis
MILESTONES IN CHEMISTRY Ian Grayson A nobel synthesis IAN GRAYSON Evonik Degussa GmbH, Rodenbacher Chaussee 4, Hanau-Wolfgang, 63457, Germany he first Nobel Prize for chemistry was because it is a scientific challenge, as he awarded in 1901 (to Jacobus van’t Hoff). described in his Nobel lecture: “The synthesis T Up to 2010, the chemistry prize has been of brazilin would have no industrial value; awarded 102 times, to 160 laureates, of whom its biological importance is problematical, only four have been women (1). The most but it is worth while to attempt it for the prominent area for awarding the Nobel Prize sufficient reason that we have no idea how for chemistry has been in organic chemistry, in to accomplish the task” (4). which the Nobel committee includes natural Continuing the list of Nobel Laureates in products, synthesis, catalysis, and polymers. organic synthesis we arrive next at R. B. This amounts to 24 of the prizes. Reading the Woodward. Considered by many the greatest achievements of the earlier organic chemists organic chemist of the 20th century, he who were recipients of the prize, we see that devised syntheses of numerous natural they were drawn to synthesis by the structural Alfred Nobel, 1833-1896 products, including lysergic acid, quinine, analysis and characterisation of natural cortisone and strychnine (Figure 1). 6 compounds. In order to prove the structure conclusively, some In collaboration with Albert Eschenmoser, he achieved the synthesis, even if only a partial synthesis, had to be attempted. It is synthesis of vitamin B12, a mammoth task involving nearly 100 impressive to read of some of the structures which were deduced students and post-docs over many years. -
The Creation of the International Centre for Theoretical Physics in Trieste
Alexis De Greiff The tale of two peripheries The Tale of Two Peripheries: The Creation of the International Centre for Theoretical Physics in Trieste Publicado con cambios menores en Historical Studies of Physical and Biological Sciences (Special Issue, Alexis De Greiff y David Kaiser, eds.) Vol. 33, Part 1 (2002), pp. 33-60. Alexis De Greiff* Abstract: This paper can be seen in the intersection between history of 20th-century physics, diplomatic history and international relations of science. In this work I analyze the dynamics of the negotiations to create the International Centre for Theoretical Physics, which took place between 1960 and 1963 at the International Atomic Energy Agency. In contrast to previous studies on the creation of international scientific institutions, I pay special attention to the active role played by scientists, politicians and intellectuals from the host-city, Trieste (Italy). Further, I spell out the historical circumstances that allowed this group of local actors to become key figures in the establishment of the Centre. I discuss in detail their interests as well as the political and scientific environment that eventually catalysed the diplomatic efforts of the Trieste elite. The present paper is also concerned with the strategies adopted by the advocates of the idea to confront the hostility of delegations from several industrialized countries, the Soviet Union and India. A frontier is a strip which divides and links, a sour gash like a wound which heals with difficulty, a no-man’s land, a mixed territory, whose inhabitants often feel that they do not belong to any clearly-defined country, or at least they do not belong to any country with that obvious certainty with which one usually identifies with ones native land.