Human Adenovirus: Viral Pathogen with Increasing Importance
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Guide for Common Viral Diseases of Animals in Louisiana
Sampling and Testing Guide for Common Viral Diseases of Animals in Louisiana Please click on the species of interest: Cattle Deer and Small Ruminants The Louisiana Animal Swine Disease Diagnostic Horses Laboratory Dogs A service unit of the LSU School of Veterinary Medicine Adapted from Murphy, F.A., et al, Veterinary Virology, 3rd ed. Cats Academic Press, 1999. Compiled by Rob Poston Multi-species: Rabiesvirus DCN LADDL Guide for Common Viral Diseases v. B2 1 Cattle Please click on the principle system involvement Generalized viral diseases Respiratory viral diseases Enteric viral diseases Reproductive/neonatal viral diseases Viral infections affecting the skin Back to the Beginning DCN LADDL Guide for Common Viral Diseases v. B2 2 Deer and Small Ruminants Please click on the principle system involvement Generalized viral disease Respiratory viral disease Enteric viral diseases Reproductive/neonatal viral diseases Viral infections affecting the skin Back to the Beginning DCN LADDL Guide for Common Viral Diseases v. B2 3 Swine Please click on the principle system involvement Generalized viral diseases Respiratory viral diseases Enteric viral diseases Reproductive/neonatal viral diseases Viral infections affecting the skin Back to the Beginning DCN LADDL Guide for Common Viral Diseases v. B2 4 Horses Please click on the principle system involvement Generalized viral diseases Neurological viral diseases Respiratory viral diseases Enteric viral diseases Abortifacient/neonatal viral diseases Viral infections affecting the skin Back to the Beginning DCN LADDL Guide for Common Viral Diseases v. B2 5 Dogs Please click on the principle system involvement Generalized viral diseases Respiratory viral diseases Enteric viral diseases Reproductive/neonatal viral diseases Back to the Beginning DCN LADDL Guide for Common Viral Diseases v. -
Genetic Content and Evolution of Adenoviruses Andrew J
Journal of General Virology (2003), 84, 2895–2908 DOI 10.1099/vir.0.19497-0 Review Genetic content and evolution of adenoviruses Andrew J. Davison,1 Ma´ria Benko´´ 2 and Bala´zs Harrach2 Correspondence 1MRC Virology Unit, Institute of Virology, Church Street, Glasgow G11 5JR, UK Andrew Davison 2Veterinary Medical Research Institute, Hungarian Academy of Sciences, H-1581 Budapest, [email protected] Hungary This review provides an update of the genetic content, phylogeny and evolution of the family Adenoviridae. An appraisal of the condition of adenovirus genomics highlights the need to ensure that public sequence information is interpreted accurately. To this end, all complete genome sequences available have been reannotated. Adenoviruses fall into four recognized genera, plus possibly a fifth, which have apparently evolved with their vertebrate hosts, but have also engaged in a number of interspecies transmission events. Genes inherited by all modern adenoviruses from their common ancestor are located centrally in the genome and are involved in replication and packaging of viral DNA and formation and structure of the virion. Additional niche-specific genes have accumulated in each lineage, mostly near the genome termini. Capture and duplication of genes in the setting of a ‘leader–exon structure’, which results from widespread use of splicing, appear to have been central to adenovirus evolution. The antiquity of the pre-vertebrate lineages that ultimately gave rise to the Adenoviridae is illustrated by morphological similarities between adenoviruses and bacteriophages, and by use of a protein-primed DNA replication strategy by adenoviruses, certain bacteria and bacteriophages, and linear plasmids of fungi and plants. -
A Mini Review of the Zoonotic Threat Potential of Influenza Viruses, Coronaviruses, Adenoviruses, and Enteroviruses
MINI REVIEW published: 09 April 2018 doi: 10.3389/fpubh.2018.00104 A Mini Review of the Zoonotic Threat Potential of influenza viruses, Coronaviruses, Adenoviruses, and Enteroviruses Emily S. Bailey1,2*, Jane K. Fieldhouse1,2, Jessica Y. Choi 1,2 and Gregory C. Gray1,2,3,4 1 Duke Global Health Institute, Duke University, Durham, NC, United States, 2 Division of Infectious Diseases, Duke University School of Medicine, Durham, NC, United States, 3 Global Health Research Center, Duke-Kunshan University, Kunshan, China, 4 Emerging Infectious Diseases Program, Duke-NUS Medical School, Singapore During the last two decades, scientists have grown increasingly aware that viruses are emerging from the human–animal interface. In particular, respiratory infections are problematic; in early 2003, World Health Organization issued a worldwide alert for a previously unrecognized illness that was subsequently found to be caused by a novel Edited by: Margaret Ip, coronavirus [severe acute respiratory syndrome (SARS) virus]. In addition to SARS, The Chinese University other respiratory pathogens have also emerged recently, contributing to the high bur- of Hong Kong, China den of respiratory tract infection-related morbidity and mortality. Among the recently Reviewed by: Peng Yang, emerged respiratory pathogens are influenza viruses, coronaviruses, enteroviruses, Beijing Center for Disease and adenoviruses. As the genesis of these emerging viruses is not well understood Prevention and Control, China and their detection normally occurs after they have crossed over and adapted to man, Sergey Eremin, World Health Organization ideally, strategies for such novel virus detection should include intensive surveillance at (Switzerland), Switzerland the human–animal interface, particularly if one believes the paradigm that many novel *Correspondence: emerging zoonotic viruses first circulate in animal populations and occasionally infect Emily S. -
Viral Diseases (Oral Presentation) a Pressing Need of Developing New Anti-T
e174 14th International Congress on Infectious Diseases (ICID) Abstracts achieved important reductions in the incidence of Chagas in life. The availability of rapid diagnostic tools and dona- disease in many Latin American countries. However, this tions of several drugs from pharmaceutical companies, and approach has been ineffective in some geographic areas the reduced price of other essential antihelminthic drugs such as the Gran Chaco. As a result, the development of has catalysed the rapid expansion of chemotherapy-based effective new tools in these areas to prevent house rein- control programmes for NTDs. The main challenges to PTC festation by triatomine bugs is a high research priority. No in Africa include poor health service infrastructure in post less important is the need of innovative approaches includ- conflict countries and cost-effective approaches for inte- ing those generated from genomics to improve upon existing grating the individual vertical programmes targeting specific diagnostic tests and to develop new parasitological tests diseases. for the early diagnosis of congenital infection in the new- born and in immunocompromised patients, as well as for doi:10.1016/j.ijid.2010.02.1872 the assessment of treatment response (PCR; antigenemia, recombinant antigens,synthetic peptides etc.). There is also Viral diseases (Oral Presentation) a pressing need of developing new anti-T. cruzi agents with high activity in both the acute and chronic phases, and epi- 40.001 demiological methods that me may be used to estimate the Unusual clinical profile of Dengue Infection in patients prevalence of infection, subclinical disease and treatment attending a tertiary care teaching hospital in north India needs in endemic and non-endemic countries. -
Virkon S Virucidal Efficacy
Virkon S Virucidal Efficacy Group Genera Organism Ref. Strain Country Dilution DNA /RNA Disease Organism No Adenoviridae Aviadenovirus Adenovirus 51 Italy 1:100 dsDNA Aviadenovirus Adenovirus 89 France 1:100 dsDNA Aviadenovirus Adenovirus 12 Strain EDS England 1:100 dsDNA egg drop poultry ana1 127 syndrome Aviadenovirus Adenovirus 71 ATCC VR-921 USA 1:100 dsDNA egg drop poultry ana2 (Duck) syndrome Mastadenovirus ICH virus 49 Purdue strain USA 1:100 dsDNA ICH dog Mastadenovirus Bovine 143 ATCC VR-640 USA 1:100 dsDNA cattle adenovirus type 4 Mastadenovirus ICH virus 171 ATCC VR800 USA 1:100 dsDNA ICH dog Arenaviridae Arenavirus Lassa fever 19 England 1:200 ssRNA lassa fever man virus Astroviridae Astrovirus PEMS 184 not specified USA 1:67 ssRNA Poult turkey associated Enteritis astrovirus Mortality Syndrome Baculoviridae Baculovirus White spotted 181 White spotted Thailand 9ppm dsDNA White Spot Prawn / red baculovirus red virus Syndrome shrimp Birnaviridae Birnavirus IBD virus 5 Strain 52/70 England 1:250 dsRNA Gumboro poultry IBD virus 44 Strain DV86 England 1:250 dsRNA Gumboro poultry IBD virus 111 USA 1:100 dsRNA Gumboro poultry IBD virus 154 USA 1:100 dsRNA Gumboro IBD virus 177 Canada 1:100 dsRNA Gumboro Bunyaviridae Phlebovirus Rift valley fever 18 England 1:400 ssRNA rift valley cattle, virus fever man Phlebovirus Rift valley fever 82 Ar 55171 Nigeria 1:500 ssRNA rift valley sheep, virus fever goats Caliciviridae Calicivirus Feline calici 135 England 1:50 ssRNA resp. cat virus disease complex Feline calici 138 ATCC VR782 USA 1:100 -
HUMAN ADENOVIRUS Credibility of Association with Recreational Water: Strongly Associated
6 Viruses This chapter summarises the evidence for viral illnesses acquired through ingestion or inhalation of water or contact with water during water-based recreation. The organisms that will be described are: adenovirus; coxsackievirus; echovirus; hepatitis A virus; and hepatitis E virus. The following information for each organism is presented: general description, health aspects, evidence for association with recreational waters and a conclusion summarising the weight of evidence. © World Health Organization (WHO). Water Recreation and Disease. Plausibility of Associated Infections: Acute Effects, Sequelae and Mortality by Kathy Pond. Published by IWA Publishing, London, UK. ISBN: 1843390663 192 Water Recreation and Disease HUMAN ADENOVIRUS Credibility of association with recreational water: Strongly associated I Organism Pathogen Human adenovirus Taxonomy Adenoviruses belong to the family Adenoviridae. There are four genera: Mastadenovirus, Aviadenovirus, Atadenovirus and Siadenovirus. At present 51 antigenic types of human adenoviruses have been described. Human adenoviruses have been classified into six groups (A–F) on the basis of their physical, chemical and biological properties (WHO 2004). Reservoir Humans. Adenoviruses are ubiquitous in the environment where contamination by human faeces or sewage has occurred. Distribution Adenoviruses have worldwide distribution. Characteristics An important feature of the adenovirus is that it has a DNA rather than an RNA genome. Portions of this viral DNA persist in host cells after viral replication has stopped as either a circular extra chromosome or by integration into the host DNA (Hogg 2000). This persistence may be important in the pathogenesis of the known sequelae of adenoviral infection that include Swyer-James syndrome, permanent airways obstruction, bronchiectasis, bronchiolitis obliterans, and steroid-resistant asthma (Becroft 1971; Tan et al. -
Characterization of a Novel Species of Adenovirus from Japanese Microbat
www.nature.com/scientificreports OPEN Characterization of a novel species of adenovirus from Japanese microbat and role of CXADR Received: 23 August 2018 Accepted: 4 December 2018 as its entry factor Published: xx xx xxxx Tomoya Kobayashi1, Hiromichi Matsugo1, Junki Maruyama 2, Haruhiko Kamiki1, Ayato Takada2, Ken Maeda3, Akiko Takenaka-Uema1, Yukinobu Tohya4, Shin Murakami1 & Taisuke Horimoto1 Recently, bat adenoviruses (BtAdVs) of genus Mastadenovirus have been isolated from various bat species, some of them displaying a wide host range in cell culture. In this study, we isolated two BtAdVs from Japanese wild microbats. While one isolate was classifed as Bat mastadenovirus A, the other was phylogenetically independent of other BtAdVs. It was rather related to, but serologically diferent from, canine adenoviruses. We propose that the latter, isolated from Asian parti-colored bat, should be assigned to a novel species of Bat mastadenovirus. Both isolates replicated in various mammalian cell lines, implying their wide cell tropism. To gain insight into cell tropism of these BtAdVs, we investigated the coxsackievirus and adenovirus receptor (CXADR) for virus entry to the cells. We prepared CXADR- knockout canine kidney cells and found that replication of BtAdVs was signifcantly hampered in these cells. For confrmation, their replication in canine CXADR-addback cells was rescued to the levels with the original cells. We also found that viral replication was corrected in human or bat CXADR-transduced cells to similar levels as in canine CXADR-addback cells. These results suggest that BtAdVs were able to use several mammalian-derived CXADRs as entry factors. Adenovirus (AdV) is a non-enveloped, double-stranded DNA virus, and is divided into five genera: Mastadenovirus, Atadenovirus, Ichtadenovirus, Siadenovirus, and Aviadenovirus. -
Review of Coliphages As Possible Indicators of Fecal Contamination for Ambient Water Quality
REVIEW OF COLIPHAGES AS POSSIBLE INDICATORS OF FECAL CONTAMINATION FOR AMBIENT WATER QUALITY 820-R-15-098 EPA Office of Water Office of Science and Technology Health and Ecological Criteria Division April 17, 2015 NOTICES This document has been drafted and approved for publication by the Health and Ecological Criteria Division, Office of Science and Technology, United States (U.S.) Environmental Protection Agency (EPA), and is approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. i ACKNOWLEDGMENTS The development of this criteria document was made possible through an effort led by Sharon Nappier, EPA Project Manager, EPA, Office of Science and Technology, Office of Water. EPA acknowledges the valuable contributions of EPA Internal Technical Reviewers who reviewed this document: Jamie Strong and Elizabeth Doyle. The project described here was managed by the Office of Science and Technology, Office of Water, EPA under EPA Contract EP-C-11-005 to ICF International. EPA also wishes to thank Audrey Ichida, Kirsten Jaglo, Jeffrey Soller, Arun Varghese, Alexandria Boehm, Kara Nelson, Margaret Nellor, and Kaedra Jones for their contributions and invaluable support. The primary contact regarding questions or comments to this document is: Sharon Nappier U.S. EPA Headquarters Office of Science and Technology, Office of Water 1200 Pennsylvania Ave., NW Washington, DC 20460 Mail Code 4304T Phone: (202) 566-0740 Email: [email protected] ii EXTERNAL PEER REVIEW WORKGROUP The External Peer Review was managed by the Office of Science and Technology, Office of Water, EPA under EPA Contract No. EP-C-13-010 to Versar, Inc. -
Functionalized Surfaces As a Tool for Virus Sensing: a Demonstration of Human Mastadenovirus Detection in Environmental Waters
chemosensors Article Functionalized Surfaces as a Tool for Virus Sensing: A Demonstration of Human mastadenovirus Detection in Environmental Waters Juliana Schons Gularte 1,2,* , Roana de Oliveira Hansen 3 , Meriane Demoliner 1,2, Jacek Fiutowski 3, Ana Karolina Antunes Eisen 1,2, Fagner Henrique Heldt 1,2 , Paula Rodrigues de Almeida 1,2 , Daniela Müller de Quevedo 4, Horst-Günter Rubahn 3 and Fernando Rosado Spilki 1,2 1 Laboratório de Microbiologia Molecular, Universidade Feevale, ERS 239, 2755, Novo Hamburgo RS 93352-000, Brazil; [email protected] (M.D.); [email protected] (A.K.A.E.); [email protected] (F.H.H.); [email protected] (P.R.d.A.); [email protected] (F.R.S.) 2 Laboratório de Saúde Única, Feevale Techpark, Universidade Feevale, Av. Edgar Hoffmeister, 600–Zona Industrial Norte, Campo Bom RS 93700-000, Brazil 3 NanoSYD, The Mads Clausen Institute, University of Southern Denmark, Alsion 2, 6400 Sønderborg, Denmark; [email protected] (R.d.O.H.); fi[email protected] (J.F.); [email protected] (H.-G.R.) 4 Programa de Pós-Graduação em Qualidade Ambiental, Universidade Feevale, ERS 239, 2755, Novo Hamburgo RS 93352-000, Brazil; [email protected] * Correspondence: [email protected]; Tel.: +55-51-3586-8800 (ext. 9284) Abstract: The main goal of this study was to apply magnetic bead surface functionalization in the Citation: Gularte, J.S.; de Oliveira form of immunomagnetic separation (IMS) combined with real-time polymerase chain reaction Hansen, R.; Demoliner, M.; Fiutowski, (qPCR) (IMS-qPCR) to detect Human mastadenovirus species C (HAdV-C) and F (HAdV-F) in water J.; Eisen, A.K.A.; Heldt, F.H.; Almeida, samples. -
RIDA GENE Adenovirus PG1005
® RIDA GENE Adenovirus PG1005 R-Biopharm AG, An der neuen Bergstraße 17, 64297 Darmstadt, Germany Phone: +49 (0) 61 51 81 02-0 / Fax: +49 (0) 61 51 81 02-20 1. Intended use For in vitro diagnostic use. RIDA ®GENE Adenovirus is a multiplex real-time PCR for the direct, qualitative detection of Adenovirus in human stool samples, throat rinsing fluid, sputum and bronchoalveolar lavage (BAL). The RIDA ®GENE Adenovirus real-time PCR is intended for use as an aid in diagnosis of respiratory infections caused by adenoviruses. 2. Summary and explanation of the test Adenoviruses are non-enveloped ikosaedric double-stranded DNA (dsDNA) viruses and belong to the family of Adenoviridae. They were isolated from human pharyngeal tonsils (Adenoides), where their name originated from. 1 One differentiates 56 serotypes of human adenoviruses and they are classified into seven groups (A - G).4,5 Adenoviruses cause a variety of different clinical pictures. Besides ocular and gastrointestinal infections, adenoviruses mostly cause respiratory disease. The latter one is primarily observed in small children under the age of four since they lack humoral immunity. However, 1 – 7 % of adult respiratory infections are caused by adenoviruses. 1 The symptoms of an adenovirus infection reach from cold, acute bronchitis to pneumonia and in immunocompromised patients, also acute respiratory distress syndrome (ARDS) is observed. Acute respiratory infections are mainly caused by serotypes 1, 2, 3, 4, 6, 7, 14 and 21, whereas serotypes 1, 2, 3, 4 and 7 are the major causes of pneumonia. Many adenoviruses are endemic with adenovirus outbreaks being often described on military bases. -
Viruses Infecting Reptiles
Viruses 2011, 3, 2087-2126; doi:10.3390/v3112087 OPEN ACCESS viruses ISSN 1999-4915 www.mdpi.com/journal/viruses Review Viruses Infecting Reptiles Rachel E. Marschang Institut für Umwelt und Tierhygiene, University of Hohenheim, Garbenstr. 30, 70599 Stuttgart, Germany; E-Mail: [email protected]; Tel.: +49-711-459-22468; Fax: +49-711-459-22431 Received: 2 September 2011; in revised form: 19 October 2011 / Accepted: 21 October 2011 / Published: 1 November 2011 Abstract: A large number of viruses have been described in many different reptiles. These viruses include arboviruses that primarily infect mammals or birds as well as viruses that are specific for reptiles. Interest in arboviruses infecting reptiles has mainly focused on the role reptiles may play in the epidemiology of these viruses, especially over winter. Interest in reptile specific viruses has concentrated on both their importance for reptile medicine as well as virus taxonomy and evolution. The impact of many viral infections on reptile health is not known. Koch’s postulates have only been fulfilled for a limited number of reptilian viruses. As diagnostic testing becomes more sensitive, multiple infections with various viruses and other infectious agents are also being detected. In most cases the interactions between these different agents are not known. This review provides an update on viruses described in reptiles, the animal species in which they have been detected, and what is known about their taxonomic positions. Keywords: reptile; taxonomy; iridovirus; herpesvirus; adenovirus; paramyxovirus 1. Introduction Reptile virology is a relatively young field that has undergone rapid development over the past few decades. -
(12) Patent Application Publication (10) Pub. No.: US 2017/0042898A1 Berenson Et Al
US 20170042898A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2017/0042898A1 Berenson et al. (43) Pub. Date: Feb. 16, 2017 (54) METHODS AND COMPOSITIONS FOR Publication Classification TREATINGVIRAL OR VIRALLY-INDUCED (51) Int. Cl. CONDITIONS A63L/506 (2006.01) A6IR 9/00 (2006.01) (71) Applicants: HEMAQUEST A638/12 (2006.01) PHARMACEUTICALS, INC., San A6II 3/19 (2006.01) Diego, CA (US); TRUSTEES OF A6II 3/18 (2006.01) BOSTON UNIVERSITY, Boston, MA A6II 3/167 (2006.01) (US) A63L/4045 (2006.01) (72) Inventors: Ronald J. Berenson, Mercer Island, A6II 3/165. (2006.01) WA (US); Douglas V. Faller, Weston, A638/15 (2006.01) A6II 3/4402 (2006.01) MA (US) A6II 3/522 (2006.01) (73) Assignees: HEMAQUEST A6II 3/473 (2006.01) PHARMACEUTICALS, INC., San (52) U.S. Cl. Diego, CA (US); TRUSTEES OF CPC ........... A61 K3I/506 (2013.01); A61 K3I/522 BOSTON UNIVERSITY, Boston, MA (2013.01); A61K 9/0053 (2013.01); A61 K (US) 38/12 (2013.01); A61K 31/19 (2013.01); A61 K 3 1/473 (2013.01); A61K 31/167 (2013.01); (21) Appl. No.: 15/335,776 A61K 31/4045 (2013.01); A61K 3 1/165 (2013.01); A61K 38/15 (2013.01); A61 K (22) Filed: Oct. 27, 2016 3I/4402 (2013.01); A61K 31/18 (2013.01) Related U.S. Application Data (63) Continuation of application No. 14/728,592, filed on (57) ABSTRACT Jun. 2, 2015, now abandoned, which is a continuation of application No. 13/912,637, filed on Jun. 7, 2013, Provided are methods and compositions for the prevention now abandoned, which is a continuation of applica and/or treatment of viral conditions, virally-induced condi tion No.