DOCSLIB.ORG

Pyridoxamine: a Novel Treatment for Schizophrenia with Enhanced Carbonyl Stress

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Pyridoxamine: a Novel Treatment for Schizophrenia with Enhanced Carbonyl Stress Psychiatry and Clinical Neurosciences 2018; 72:35–44 doi:10.1111/pcn.12613 Regular Article Pyridoxamine: A novel treatment for schizophrenia with enhanced carbonyl stress , ,† ,† Masanari Itokawa, MD, PhD,1,2,3 * Mitsuhiro Miyashita, MD, PhD ,1,2,4 Makoto Arai, PhD,1 Takashi Dan, MD, PhD,5 Katsuyoshi Takahashi, MD, PhD,2 Taro Tokunaga, MD,2 Kayo Ishimoto, MD,2 Kazuya Toriumi, PhD,1 Tomoe Ichikawa, PhD,1 Yasue Horiuchi, PhD,1 Akiko Kobori, MS,1 Satoshi Usami, PhD,6 Takeo Yoshikawa, MD, PhD,3 Naoji Amano, MD, PhD,4 Shinsuke Washizuka, MD, PhD,4 Yuji Okazaki, MD2 and Toshio Miyata, MD, PhD5 1Project for Schizophrenia Research, Tokyo Metropolitan Institute of Medical Science, 2Department of Psychiatry, Tokyo Metropolitan Matsuzawa Hospital, Tokyo, 3Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, 4Department of Psychiatry, Shinshu University School of Medicine, Matsumoto, 5Division of Molecular Medicine and Therapy, Tohoku University Graduate School of Medicine, Sendai, and 6Graduate School of Education, University of Tokyo, Tokyo, Japan Aim: The aim of this clinical trial was to obtain considerable reduction in psychosis accompanied proof of concept for high-dose pyridoxamine as a with a moderate decrease in plasma pentosidine novel treatment for schizophrenia with enhanced levels. A reduction of greater than 20% in the carbonyl stress. assessment scale of drug-induced Parkinsonism occurred in four patients. Although there was no Methods: Ten Japanese schizophrenia patients with severe suicide-related ideation or behavior, Wer- high plasma pentosidine, which is a representative nicke’s encephalopathy-like adverse drug reactions biomarker of enhanced carbonyl stress, were recruited occurred in two patients and were completely sup- in a 24-week, open trial in which high-dose pyridox- pressed by thiamine supplementation. amine (ranging from 1200 to 2400 mg/day) was administered using a conventional antipsychotic regi- Conclusion: High-dose pyridoxamine add-on treat- men. Main outcomes were the total change in Positive ment was, in part, effective for a subpopulation of and Negative Syndrome Scale score and the Brief Psy- schizophrenia patients with enhanced carbonyl chiatric Rating Scale score from baseline to end of stress. Further randomized, placebo-controlled trials treatment at week 24 (or at withdrawal). with careful monitoring will be required to validate the efficacy of high-dose pyridoxamine for these Results: Decreased plasma pentosidine levels were patients. observed in eight patients. Two patients showed marked improvement in their psychological symp- toms. A patient who harbors a frameshift muta- Key words: advanced glycation end-products, car- tion in the Glyoxalase 1 gene also showed bonyl stress, pentosidine, pyridoxamine, schizophrenia. CHIZOPHRENIA IS A devastating disorder char- S acterized by positive symptoms, including audi- *Correspondence: Masanari Itokawa, MD, PhD, Center for Medical tory hallucinations and delusions, and negative Research Cooperation, Tokyo Metropolitan Institute of Medical Science, symptoms, including blunted affect, anhedonia, and 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan. cognitive deficits. The lifetime prevalence ranges Email: [email protected] † from approximately 0.3% to 0.7%, and disease Both authors contributed equally to this manuscript. Received 11 June 2017; revised 7 September 2017; onset frequently occurs during puberty or early ado- accepted 18 October 2017. lescence. Adequate psychosocial support as well as © 2017 The Authors 35 Psychiatry and Clinical Neurosciences © 2017 Japanese Society of Psychiatry and Neurology 36 M. Itokawa et al. Psychiatry and Clinical Neurosciences 2018; 72:35–44 psychopharmacologic treatment is needed to achieve In contrast, clinical interventions, such as pyridox- and maintain recovery. Although many studies have amine supplementation, aimed at reducing carbonyl been conducted to clarify the underlying mechanism stress, may provide a safe and effective treatment for of the disease, the main cause and pathophysiology schizophrenia patients with enhanced carbonyl of schizophrenia still remains elusive since there is stress. To test this hypothesis, we conducted a 24- considerable heterogeneity in symptoms, and long- week, open-label clinical trial with high-dose pyri- term clinical courses differ substantially from patient doxamine supplementation in schizophrenia to patient. patients. In this study, two patients showed marked Carbonyl stress is an abnormal metabolic state improvement in clinical symptoms, and one patient resulting from either increased production of reac- showed considerable improvement in psychological tive carbonyl compounds (RCO) or decreased detox- symptoms accompanied by a moderate decrease in ification of RCO.1 Advanced glycation end products plasma pentosidine levels. Additionally, four partici- (AGE) are generated as a consequence of elevated pants showed improvements in drug-induced Par- carbonyl stress, and numerous experimental studies kinsonism and two patients experienced Wernicke’s in animals and humans implicate increased AGE in encephalopathy, which was completely alleviated – a variety of diseases, including diabetes mellitus,2 4 following thiamine supplementation. chronic kidney disease,1 cardiovascular diseases5 and cognitive impairment with or without – METHODS dementia.6 8 Pyridoxamine, one of the three forms of vitamin B6, is capable of scavenging certain RCO, Subjects thereby inhibiting the formation of AGE and allevi- Inclusion criteria for this clinical trial were patients ating their unfavorable physiological effects. The with schizophrenia or schizoaffective disorder aged other forms of vitamin B6, pyridoxine and pyridoxal, 20–65 years who were hospitalized in Matsuzawa fi lack this therapeutic bene t. However, pyridoxamine Metropolitan Hospital. Diagnoses were made by at is synthesized from both pyridoxal and pyridoxine least two experienced psychiatrists according to the in vivo, so that depleting pyridoxamine to combat DSM-IV-TR. Patients with diabetes mellitus or chronic enhanced carbonyl stress eventually leads to kidney disease were excluded, since both diseases decreases in both pyridoxal and pyridoxine. occasionally induce increased plasma pentosidine We previously reported that enhanced carbonyl levels. Other exclusion criteria included: organic men- stress is associated with a subpopulation of patients tal diseases, substance dependence, past history of 9 suffering from schizophrenia. In addition, a close substance dependence, comorbid malignant tumors, relationship between schizophrenia and carbonyl pregnancy, modified electroconvulsive therapy within 10 stress was also found in a larger cohort, and a 3 months, prescription to theophylline, choline the- drug-naïve patient with high pentosidine levels has ophylline, aminophylline and levodopa (which are 11 been reported. Clinical features of patients with contraindicated with pyridoxamine), and severe phys- enhanced carbonyl stress are similar to those with ical conditions that made study participation inappro- treatment-resistant schizophrenia, and negative cor- priate. Eligible patients exhibited enhanced carbonyl relations between psychological symptoms of stress defined as elevated plasma pentosidine levels schizophrenia and serum pyridoxal levels have been according to a previous report9 (>55.2 ng/mL; defined 12 reported. Likewise, a recent study suggests that above 2 SD of healthy control subjects). In this study, pyridoxal levels could be a possible biomarker to serum pyridoxal levels could not be used as an inclu- predict the clinical course in a subset of schizophre- sion criterion because the number of patients fulfilling 13 nia patients. Clozapine is the most effective agent both high pentosidine and low pyridoxal were so few among various antipsychotics for patients with that sufficient participants could not be recruited. 14,15 treatment-resistant schizophrenia. However, the After patient selection, 10 eligible patients were identi- use of clozapine is restricted because of serious and fied for this clinical trial. lethal adverse effects, including granulocytopenia,16 which require strict and frequent monitoring of white blood cell counts. Thus, clozapine treatment Study design causes problems for both patients as well as health- A 24-week, open-label design was adopted. Pyridox- care providers. amine was initiated with a dose of 1200 mg/day © 2017 The Authors Psychiatry and Clinical Neurosciences © 2017 Japanese Society of Psychiatry and Neurology Psychiatry and Clinical Neurosciences 2018; 72:35–44 Pyridoxamine treatment for schizophrenia 37 supplementing the existing antipsychotic regimen, phosphate-buffered saline. A sample (corresponding with the responsible doctor setting the daily dose to 25 μg of protein) was injected into an HPLC sys- (1200, 1800, or 2400 mg/day) during the trial. The tem and fractionated on a C18 reverse-phase col- dose was determined according to phase I clinical umn. Eluent was monitored at excitation-emission trials. To avoid degradation, we stored pyridoxamine wavelengths of 335/385 nm using a fluorescence in powder form in a light-blocking box and dis- detector (RF-10A; Shimadzu, Kyoto, Japan). Syn- solved it in water and syrup (to reduce sourness) for thetic pentosidine was used to obtain a standard three daily oral administrations. Treatment adher- curve. Three forms of vitamin B6 (pyridoxine, pyri- ence and the general condition of all participants doxal,
Load more

Recommended publications
  • Guidelines on Food Fortification with Micronutrients
    GUIDELINES ON FOOD FORTIFICATION FORTIFICATION FOOD ON GUIDELINES Interest in micronutrient malnutrition has increased greatly over the last few MICRONUTRIENTS WITH years. One of the main reasons is the realization that micronutrient malnutrition contributes substantially to the global burden of disease. Furthermore, although micronutrient malnutrition is more frequent and severe in the developing world and among disadvantaged populations, it also represents a public health problem in some industrialized countries. Measures to correct micronutrient deficiencies aim at ensuring consumption of a balanced diet that is adequate in every nutrient. Unfortunately, this is far from being achieved everywhere since it requires universal access to adequate food and appropriate dietary habits. Food fortification has the dual advantage of being able to deliver nutrients to large segments of the population without requiring radical changes in food consumption patterns. Drawing on several recent high quality publications and programme experience on the subject, information on food fortification has been critically analysed and then translated into scientifically sound guidelines for application in the field. The main purpose of these guidelines is to assist countries in the design and implementation of appropriate food fortification programmes. They are intended to be a resource for governments and agencies that are currently implementing or considering food fortification, and a source of information for scientists, technologists and the food industry. The guidelines are written from a nutrition and public health perspective, to provide practical guidance on how food fortification should be implemented, monitored and evaluated. They are primarily intended for nutrition-related public health programme managers, but should also be useful to all those working to control micronutrient malnutrition, including the food industry.
    [Show full text]
  • Potato - Analysis of Nutrients by Veronica Öhrvik, Irene Mattisson, Sören Wretling and Christina Åstrand
    Rapport 19 − 2010 Potato - analysis of nutrients by Veronica Öhrvik, Irene Mattisson, Sören Wretling and Christina Åstrand LIVSMEDELS VERKET NATIONAL FOOD ADMINISTRATION, Sweden Content Summary .................................................................................................................................... 2 Background ................................................................................................................................ 3 Materials and methods ............................................................................................................... 4 Sampling potatoes .................................................................................................................. 4 Varieties ............................................................................................................................. 4 Geographical distribution ................................................................................................... 5 Catering potato ................................................................................................................... 5 Sample handling ..................................................................................................................... 7 Quality assurance of analytical methods ................................................................................ 8 Analysed nutrients .................................................................................................................. 9 Calculation of nutritional
    [Show full text]
  • Cytokinins / Coconut Water
    Molecules 2009, 14, 5144-5164; doi:10.3390/molecules14125144 OPEN ACCESS molecules ISSN 1420-3049 www.mdpi.com/journal/molecules Review The Chemical Composition and Biological Properties of Coconut (Cocos nucifera L.) Water Jean W. H. Yong, Liya Ge, Yan Fei Ng and Swee Ngin Tan * Natural Sciences and Science Education Academic Group, Nanyang Technological University, 1 Nanyang Walk, 637616 Singapore * Author to whom correspondence should be addressed; E-Mail: [email protected]; Tel.: +65-6790 3810; Fax: +65-6896 9432. Received: 3 November 2009; in revised form: 3 December 2009 / Accepted: 8 December 2009 / Published: 9 December 2009 Abstract: Coconut water (coconut liquid endosperm), with its many applications, is one of the world’s most versatile natural product. This refreshing beverage is consumed worldwide as it is nutritious and beneficial for health. There is increasing scientific evidence that supports the role of coconut water in health and medicinal applications. Coconut water is traditionally used as a growth supplement in plant tissue culture/micropropagation. The wide applications of coconut water can be justified by its unique chemical composition of sugars, vitamins, minerals, amino acids and phytohormones. This review attempts to summarise and evaluate the chemical composition and biological properties of coconut water. Keywords: coconut water; phytohormone; auxin; cytokinin; gibberellin; inorganic ion; vitamin 1. Introduction The coconut (Cocos nucifera L.) is an important fruit tree in the tropical regions and the fruit can be made into a variety of foods and beverages (Figure 1). The edible part of the coconut fruit (coconut meat and coconut water) is the endosperm tissue.
    [Show full text]
  • Circulatory and Urinary B-Vitamin Responses to Multivitamin Supplement Ingestion Differ Between Older and Younger Adults
    nutrients Article Circulatory and Urinary B-Vitamin Responses to Multivitamin Supplement Ingestion Differ between Older and Younger Adults Pankaja Sharma 1,2 , Soo Min Han 1 , Nicola Gillies 1,2, Eric B. Thorstensen 1, Michael Goy 1, Matthew P. G. Barnett 2,3 , Nicole C. Roy 2,3,4,5 , David Cameron-Smith 1,2,6 and Amber M. Milan 1,3,4,* 1 The Liggins Institute, University of Auckland, Auckland 1023, New Zealand; [email protected] (P.S.); [email protected] (S.M.H.); [email protected] (N.G.); [email protected] (E.B.T.); [email protected] (M.G.); [email protected] (D.C.-S.) 2 Riddet Institute, Palmerston North 4474, New Zealand; [email protected] (M.P.G.B.); [email protected] (N.C.R.) 3 Food & Bio-based Products Group, AgResearch, Palmerston North 4442, New Zealand 4 High-Value Nutrition National Science Challenge, Auckland 1023, New Zealand 5 Department of Human Nutrition, University of Otago, Dunedin 9016, New Zealand 6 Singapore Institute for Clinical Sciences, Agency for Science, Technology, and Research, Singapore 117609, Singapore * Correspondence: [email protected]; Tel.: +64-(0)9-923-4785 Received: 23 October 2020; Accepted: 13 November 2020; Published: 17 November 2020 Abstract: Multivitamin and mineral (MVM) supplements are frequently used amongst older populations to improve adequacy of micronutrients, including B-vitamins, but evidence for improved health outcomes are limited and deficiencies remain prevalent. Although this may indicate poor efficacy of supplements, this could also suggest the possibility for altered B-vitamin bioavailability and metabolism in older people.
    [Show full text]
  • Dietary Supplements Compendium Volume 1
    2015 Dietary Supplements Compendium DSC Volume 1 General Notices and Requirements USP–NF General Chapters USP–NF Dietary Supplement Monographs USP–NF Excipient Monographs FCC General Provisions FCC Monographs FCC Identity Standards FCC Appendices Reagents, Indicators, and Solutions Reference Tables DSC217M_DSCVol1_Title_2015-01_V3.indd 1 2/2/15 12:18 PM 2 Notice and Warning Concerning U.S. Patent or Trademark Rights The inclusion in the USP Dietary Supplements Compendium of a monograph on any dietary supplement in respect to which patent or trademark rights may exist shall not be deemed, and is not intended as, a grant of, or authority to exercise, any right or privilege protected by such patent or trademark. All such rights and privileges are vested in the patent or trademark owner, and no other person may exercise the same without express permission, authority, or license secured from such patent or trademark owner. Concerning Use of the USP Dietary Supplements Compendium Attention is called to the fact that USP Dietary Supplements Compendium text is fully copyrighted. Authors and others wishing to use portions of the text should request permission to do so from the Legal Department of the United States Pharmacopeial Convention. Copyright © 2015 The United States Pharmacopeial Convention ISBN: 978-1-936424-41-2 12601 Twinbrook Parkway, Rockville, MD 20852 All rights reserved. DSC Contents iii Contents USP Dietary Supplements Compendium Volume 1 Volume 2 Members . v. Preface . v Mission and Preface . 1 Dietary Supplements Admission Evaluations . 1. General Notices and Requirements . 9 USP Dietary Supplement Verification Program . .205 USP–NF General Chapters . 25 Dietary Supplements Regulatory USP–NF Dietary Supplement Monographs .
    [Show full text]
  • LYSOVIT® (B-Complex+Lysine)
    Lysovit/LPD/PK-02 LYSOVIT® (B-Complex+Lysine) 1. NAME OF THE MEDICINAL PRODUCT LYSOVIT® 2. QUALITATIVE AND QUANTITATIVE COMPOSITION LYSOVIT® Syrup 120 ml Description Each 5 ml contains: Thiamine HCl 4.16 mg Riboflavin USP 1.66 mg Pyridoxine HCl 1 mg Niacinamide USP 18 mg D-Panthenol USP 2.5 mg Cyanocobalamin USP 8.33 mcg Ascorbic Acid USP 75 mg Inositol USP 5 mg Lysine Monohydrochloride USP 33.33 mg 3. PHARMACEUTICAL FORM Syrup 4. CLINICAL PARTICULARS 4.1. THERAPEUTIC INDICATIONS 1. For maintenance of health and to meet the extra energy needs of growing children. 2. Increases appetite and helps in recovery from illnesses. 4.2. POSOLOGY AND METHOD OF ADMINISTRATION Children: 1 teaspoonful daily or as prescribed by the physician Adults: One to two teaspoonsful daily. Shake well before use. Thiamine Benefits: Thiamine is recommended for digestive problems including poor appetite, ulcerative colitis, and ongoing diarrhea. People take thiamine for conditions related to low levels of thiamine (thiamine deficiency syndromes), including beriberi and inflammation of the nerves (neuritis) associated with pellagra or pregnancy.4 1 Lysovit/LPD/PK-02 Thiamine - Daily Recommended Dietary Allowance (RDA): In adults, 1-2 mg of thiamine per day is commonly used. Infants 0-6 months, 0.2 mg Infants 7-12 months, 0.3 mg Children 1-3 years, 0.5 mg Children 4-8 years, 0.6 mg Boys 9-13 years, 0.9 mg Men 14 years and older, 1.2 mg4 Girls 9-13 years, 0.9 mg Women 14-18 years, 1 mg Women over 18 years, 1.1 mg Pregnant women, 1.4 mg Breast-feeding women, 1.5 mg Riboflavin Benefits: Riboflavin had a direct impact on maintenance of good brain function.
    [Show full text]
  • United States Patent (19) 11 Patent Number: 6,129,925 Kido Et Al
    USOO6129925A United States Patent (19) 11 Patent Number: 6,129,925 Kido et al. (45) Date of Patent: *Oct. 10, 2000 54 CONTAINER FILLED WITH INFUSION 5,770,233 6/1998 Kido et al. .............................. 424/641 LIQUIDS AND INFUSION PREPARATION FOREIGN PATENT DOCUMENTS 75 Inventors: Takae Kido; Shigeo Ii; Shun-ichi Abe; 0510687 10/1992 European Pat. Off.. Kazumasa Yokoyama, all of Osaka, 58-162515 9/1982 Japan. Japan 58-162517 9/1983 Japan. 61-058560 3/1986 Japan. 73 Assignee: Yoshitomi Pharmaceutical Industries, 62-135421 6/1987 Japan. Ltd., Osaka, Japan OTHER PUBLICATIONS * Notice: This patent issued on a continued pros Derwent Abstract N89-244721, abstracting JP 1-240469, ecution application filed under 37 CFR 1989. 1.53(d), and is subject to the twenty year Chemical Abstracts 99:146124J, 1983. patent term provisions of 35 U.S.C. Chemical Abstracts 69:89709h (1968). 154(a)(2). Primary Examiner S. Mark Clardy Assistant Examiner Kathryne E. Shelborne 21 Appl. No.: 09/032,843 Attorney, Agent, or Firm Sughrue, Mion, Zinn, Macpeak 22 Filed: Mar. 2, 1998 & Seas, PLLC 57 ABSTRACT Related U.S. Application Data An object of the present invention is to provide an infusion 60 Division of application No. 08/437,330, Apr. 21, 1995, Pat. preparation set (a container filled with infusion liquids) No. 5,770,233, which is a continuation-in-part of application useful for preparation of an infusion liquid containing No. PCT/JP93/01521, Oct. 21, 1993. Sugars, amino acids, electrolytes, a fat emulsion and Vita 30 Foreign Application Priority Data mins. The present invention is constituted by the use of a container having two compartments which are separated Oct.
    [Show full text]
  • Sensitive and Cost-Effective Detection of B Vitamins in Foods by UHPLC/MS/MS
    Rapid, Sensitive and Cost-effective Detection of B Vitamins in Foods by UHPLC/MS/MS Application Note Food Testing Author Abstract Nick Byrd A fast UHPLC/MS/MS method has been developed on the Agilent 1290 Infinity LC Campden BRI System coupled to the Agilent 6460 Triple Quadrupole LC/MS System with Agilent Jet Chipping Campden, Gloucestershire Stream technology for the extraction and determination of five B vitamins in foods. United Kingdom The method has a sensitivity of at least 1 µg/kg for all six vitamins. Introduction The B vitamins play important roles in cell metabolism and in promoting human health. They are water soluble and not stored very well by the body, necessitating daily intake through diet or nutritional supplements. Deficiencies of one or more of the B vitamins may occur fairly easily, especially during times of fasting or weight- loss diets or with diets that include substantial amounts of refined and processed food, sugar, or alcohol. The germ and bran of cereal grains are good sources of these vitamins, as are some beans, peas, and nuts. Milk and many leafy green vegetables may also supply small amounts of B vitamins. While most of the B vitamins are not harmful when ingested at high amounts, B3 and B6 can, in fact, be toxic at high concentrations, leading to neuropathy and excessive blood vessel dilation. To ensure safe levels of vitamins in foods and nutritional supplements, the European Union (EU) has put in place Regulation No. 1925/2006, specifing which vitamins can be added to foods, which foods can and cannot be fortified with vitamins, and minimum and maximum levels for vitamins in foods.
    [Show full text]
  • Pyridoxine (Pyridoxamine) 5'-Phosphate Oxidase In
    PYRIDOXINE (PYRIDOXAMINE) 5’-PHOSPHATE OXIDASE IN ARABIDOPSIS THALIANA Except where reference is made to the work of others, the work described in this dissertation is my own or was done in collaboration with my advisory committee. This dissertation does not include proprietary or classified information. Yuying Sang Certificate of Approval: Robert D. Locy Narendra K. Singh, Chair Professor Professor Biological Sciences Biological Sciences Joe H. Cherry Joanna Wysocka-Diller Emeritus Professor Associate Professor Biological Sciences Biological Sciences Fenny Dane George T. Flowers Professor Dean Horticulture Graduate School PYRIDOXINE (PYRIDOXAMINE) 5’-PHOSPHATE OXIDASE IN ARABIDOPSIS THALIANA Yuying Sang A Dissertation Submitted to the Graduate Faculty of Auburn University in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy Auburn, Alabama December 19, 2008 PYRIDOXINE (PYRIDOXAMINE) 5’-PHOSPHATE OXIDASE IN ARABIDOPSIS THALIANA Yuying Sang Permission is granted to Auburn University to make copies of this dissertation at its discretion, upon request of individuals of institutions and at their expense. The author reserves all publication right. Signature of Author Date of Graduation iii VITA Yuying Sang, daughter of Shiqing Sang and Guilan Wang, was born on January 7, 1975, in Chiping, Shandong, People’s Republic of China. She received the Bachelor of Science degree in Biology in July 1997 from Shandong Normal University and entered the Graduate School of Kunming Institute of Botany, Chinese Academy of Sciences. In the July of 2000, she graduated with a Master of Science degree in Botany and joined East China University of Science and Technology as a lab manager in the Department of Bioengineering.
    [Show full text]
  • Water-Soluble Vitamins: B-Complex and Vitamin C Fact Sheet No
    Water-Soluble Vitamins: B-Complex and Vitamin C Fact Sheet No. 9.312 Food and Nutrition Series|Health by L. Bellows and R. Moore* What are Vitamins? and their influence is felt in many parts of Quick Facts Vitamins are essential nutrients found the body. They function as coenzymes that • B-complex vitamins and in foods. They perform specific and vital help the body obtain energy from food. The vitamin C are water-soluble functions in a variety of body systems, and B vitamins are also important for normal are crucial for maintaining optimal health. appetite, good vision, and healthy skin, vitamins that are not stored The two different types of vitamins nervous system, and red blood cell formation. in the body and must be are fat-soluble vitamins and water-soluble Thiamin: Vitamin B1 replaced each day. vitamins. Fat-soluble vitamins — vitamins What is Thiamin. Thiamin, or vitamin B1, • These vitamins are easily A, D, E and K — dissolve in fat before they helps to release energy from foods, promotes destroyed or washed out are absorbed in the bloodstream to carry out normal appetite, and is important in during food storage and their functions. Excesses of these vitamins maintaining proper nervous system function. are stored in the liver, and are not needed Food Sources for Thiamin. Sources preparation. every day in the diet. For more information include peas, pork, liver, and legumes. Most • The B-complex group is on fat-soluble vitamins, see fact sheet 9.315 commonly, thiamin is found in whole grains found in a variety of foods: Fat-Soluble Vitamins: A, D, E, and K.
    [Show full text]
  • Mechanistic Aspects of Ingested Chlorine Dioxide on Thyroid Function: Impact of Oxidants on Iodide Metabolism by J
    Environmental Health Perspectives Vol. 69, pp. 249-255, 1986 Mechanistic Aspects of Ingested Chlorine Dioxide on Thyroid Function: Impact of Oxidants on Iodide Metabolism by J. Peter Bercz,* Lillian L. Jones,* Robert M. Harrington,* Rohit Bawa,* and Lyman Condie* Toxicological studies dealing with recent findings of health effects of drinking water disinfectants are reviewed. Experiments with monkeys and rodents indicate that the biological activity of ingested disin- fectants is expressed via their chemical interaction with the mucosal epithelia, secretory products, and nutritional contents of the alimentary tract. Evidence exists that a principal partner of this redox inter- action is the iodide ofnutritional origin that is ubiquitous in the gastrointestinal tract. Thus the observation that subchronic exposure to chlorine dioxide (CI02) in drinking water decreases serum thyroxine levels in mammalian species can be best explained with changes produced in the chemical form ofthe bioavailable iodide. Ongoing and previously reported mechanistic studies indicate that oxidizing agents such as chlor- ine-based disinfectants oxidize the basal iodide content of the gastrointestinal tract. The resulting reactive iodine species readily attaches to organic matter by covalent bonding. Evidence suggests that the extent to which such iodinated organics are formed is proportional to the magnitude of the electromotive force and stoichiometry of the redox couple between iodide and the disinfectant. Because the extent of thyroid uptake of the bioavailable iodide does not decrease during C102 ingestion, it seems that C102 does not cause iodide deficiency of sufficient magnitude to account for the decrease in hormonogenesis. Absorption of one or more of iodinated molecules, e.g., nutrients, hormones, or cellular constituents ofthe alimentary tract having thyromimetic or thyroid inhibitory properties, is a better hypothesis for the effects seen.
    [Show full text]
  • Nutrition Journal of Parenteral and Enteral
    Journal of Parenteral and Enteral Nutrition http://pen.sagepub.com/ Micronutrient Supplementation in Adult Nutrition Therapy: Practical Considerations Krishnan Sriram and Vassyl A. Lonchyna JPEN J Parenter Enteral Nutr 2009 33: 548 originally published online 19 May 2009 DOI: 10.1177/0148607108328470 The online version of this article can be found at: http://pen.sagepub.com/content/33/5/548 Published by: http://www.sagepublications.com On behalf of: The American Society for Parenteral & Enteral Nutrition Additional services and information for Journal of Parenteral and Enteral Nutrition can be found at: Email Alerts: http://pen.sagepub.com/cgi/alerts Subscriptions: http://pen.sagepub.com/subscriptions Reprints: http://www.sagepub.com/journalsReprints.nav Permissions: http://www.sagepub.com/journalsPermissions.nav >> Version of Record - Aug 27, 2009 OnlineFirst Version of Record - May 19, 2009 What is This? Downloaded from pen.sagepub.com by Karrie Derenski on April 1, 2013 Review Journal of Parenteral and Enteral Nutrition Volume 33 Number 5 September/October 2009 548-562 Micronutrient Supplementation in © 2009 American Society for Parenteral and Enteral Nutrition 10.1177/0148607108328470 Adult Nutrition Therapy: http://jpen.sagepub.com hosted at Practical Considerations http://online.sagepub.com Krishnan Sriram, MD, FRCS(C) FACS1; and Vassyl A. Lonchyna, MD, FACS2 Financial disclosure: none declared. Preexisting micronutrient (vitamins and trace elements) defi- for selenium (Se) and zinc (Zn). In practice, a multivitamin ciencies are often present in hospitalized patients. Deficiencies preparation and a multiple trace element admixture (containing occur due to inadequate or inappropriate administration, Zn, Se, copper, chromium, and manganese) are added to par- increased or altered requirements, and increased losses, affect- enteral nutrition formulations.
    [Show full text]