(12) United States Patent (10) Patent No.: US 9.458,509 B2 Benenson Et Al
US0094.58509B2 (12) United States Patent (10) Patent No.: US 9.458,509 B2 Benenson et al. 45) Date of Patent: Oct. 4,9 2016 (54) MULTIPLE INPUT BIOLOGIC CLASSIFIER (52) U.S. Cl. CIRCUITS FOR CELLS CPC ............. CI2O 1/6886 (2013.01): CI2N 15/63 (2013.01); C12O 1/6897 (2013.01); G06F (75) Inventors: Yates'Biseiss. Newton :"A Liliana Ron 19/20 (2013.01); G06F 19/24 (2013.01) Wroblewska,s Arlington,s MAs (US); (58)58) Field ofO ClassificationSSCO SSea h Zhen Xie, Malden, MA (US) See application file for complete search history. (73) Assignees: PRESIDENT AND FELLOWS OF HARVARD COLLEGE, Cambridge, (56) References Cited MA (US); MASSACHUSETTS INSTITUTE OF TECHNOLOGY, FOREIGN PATENT DOCUMENTS Cambridge, MA (US) WO WO 2008134593 A1 * 11/2008 (*) Notice: Subject to any disclaimer, the term of this OTHER PUBLICATIONS patent is extended or adjusted under 35 U.S.C. 154(b) by 385 days. “Encode” definition; Oxford dictionary; http://www.oxford dictionaries.com/us/definition/american english encode; accessed (21) Appl. No.: 13/811,126 Apr. 27, 2015; pp. 5-6.* (22) PCT Filed: Jul. 22, 2011 * cited by examiner (86). PCT No.: PCT/US2O11AO45038 Primary Examiner — Antonio Galisteo Gonzalez S 371 (c)(1), (74) Attorney, Agent, or Firm — Nath, Goldberg & Meyer; (2), (4) Date: Apr. 5, 2013 Tanya E. Harkins (87) PCT Pub. No.: WO2012/012739 (57) ABSTRACT PCT Pub. Date: Jan. 26, 2012 Provided herein are high-input detector modules and multi input biological classifier circuits and systems that integrate (65) Prior Publication Data Sophisticated sensing, information processing, and actuation in living cells and permit new directions in basic biology, US 2013/02O2532 A1 Aug.
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