Incapacitating Chemical Agents Implications for International Law
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Page 1 EXAMPLES of ACUTE TOXINS (By CAS#) APPENDIX V(H)-B
EXAMPLES OF ACUTE TOXINS (by CAS#) APPENDIX V(h)-B Key: SA -- Readily Absorbed Through the Skin Revised: 12/2012 ___________________________________________________ _____________ _________________________ | | | CHEMICAL NAME CAS # | SA | TARGET ORGAN | ___________________________________________________ ____________ | _ | _______________________ | AFLATOXINS 000000-00-0 | | systemic | ANILINE AND COMPOUNDS 000000-00-0 | x | blood | ARSENIC ACID AND SALTS 000000-00-0 | x | systemic | ARSENIUOS ACID AND SALTS 000000-00-0 | | systemic | ARSONIC ACID AND SALTS 000000-00-0 | | systemic | BOTULINUM TOXINS 000000-00-0 | | systemic | CYANIDE AND COMPOUNDS 000000-00-0 | x | blood | CYANOGEN AND COMPOUNDS 000000-00-0 | | blood | METHYL MERCURY AND COMPOUNDS 000000-00-0 | x | CNS | VENOM, SNAKE, CROTALUS ADAMANTEUS 000000-00-0 | | systemic | VENOM, SNAKE, CROTALUS ATROX 000000-00-0 | | systemic | MITOMYCIN C 000050-07-7 | | systemic | DINITROPHENOL, 2,4- 000051-28-5 | x | systemic | ATROPINE 000051-55-8 | x | CNS | HN2 (NITROGEN MUSTARD-2) 000051-75-2 | x | systemic | THIOTEPA 000052-24-4 | | systemic | NICOTINE 000054-11-5 | x | CNS | NITROGEN MUSTARD HYDROCHLORIDE 000055-86-7 | x | systemic | PARATHION 000056-38-2 | x | CNS | CYANIDE 000057-12-5 | x | blood | STRYCHNINE 000057-24-9 | | systemic,CNS | TUBOCURARINE CHLORIDE HYDRATE,(+)- 000057-94-3 | x | systemic | METHYL HYDRAZINE 000060-34-4 | x | pulmonary,CNS,blood | ANILINE 000062-53-3 | x | blood | DICHLORVOS 000062-73-7 | x | systemic | SODIUM FLUOROACETATE 000062-74-8 | x | systemic | COLCHICINE -
Chemical Warfare Agent (CWA) Identification Overview
Physicians for Human Rights Chemical Warfare Agent (CWA) Identification Overview Chemical Warfare Agent Identification Fact Sheet Series Table of Contents This Chemical Warfare Agent (CWA) Identification Fact Sheet is part 2 Physical Properties of a Physicians for Human Rights (PHR) series designed to fill a gap in 2 VX (Nerve Agent) 2 Sarin (Nerve Agent) knowledge among medical first responders to possible CWA attacks. 2 Tabun (Nerve Agent) This document in particular outlines differences between a select 2 BZ (Incapacitating Agent) group of vesicants and nerve agents, the deployment of which would 2 Mustard Gas (Vesicant) necessitate emergency medical treatment and documentation. 3 Collecting Samples to Test for Exposure 4 Protection PHR hopes that, by referencing these fact sheets, medical professionals 5 Symptoms may be able to correctly diagnose, treat, and document evidence of 6 Differential Diagnosis exposure to CWAs. Information in this fact sheet has been compiled from 8 Decontimanation 9 Treatment publicly available sources. 9 Abbreviations A series of detailed CWA fact sheets outlining in detail those properties and treatment regimes unique to each CWA is available at physiciansforhumanrights.org/training/chemical-weapons. phr.org Chemical Warfare Agent (CWA) Identification Overview 1 Collect urine samples, and blood and hair samples if possible, immediately after exposure Physical Properties VX • A lethal dose (10 mg) of VX, absorbed through the skin, can kill within minutes (Nerve Agent) • Can remain in environment for weeks -
Reference Manual to Mitigate Potential Terrorist Attacks Against Buildings December 2003
Risk Management Series Reference Manual to Mitigate Potential Terrorist Attacks Against Buildings December 2003 FEMA FEMA 426 FEMA 426 / December 2003 RISK MANAGEMENT SERIES Reference Manual to Mitigate Potential Terrorist Attacks Against Buildings PROVIDING PROTECTION TO PEOPLE AND BUILDINGS www.fema.gov Any opinions, findings, conclusions, or recommendations expressed in this publication do not necessarily reflect the views of FEMA. Additionally, neither FEMA or any of its employees makes any warrantee, expressed or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of any information, product, or process included in this publication. Users of information from this publication assume all liability arising from such use. he creation of the Department of Homeland Security (DHS) is one of the most significant transformations in the Federal Government in decades, establishing a department T whose first priority is to protect the nation against terrorist attacks. Within the DHS, the Directorate of Emergency Preparedness and Response (EP&R) is focused on ensuring that our nation is prepared for catastrophes, including both natural disasters and terrorist assaults. Central to this mission is the protection of people and the critical infrastructure of the built environment. This Reference Manual to Mitigate Potential Terrorist Attacks Against Buildings provides guidance to the building science community of architects and engineers, to reduce physical damage to buildings, related infrastructure, and people caused by terrorist assaults. The comprehensive approach to understanding how to improve security in high occupancy buildings will better protect the nation from potential threats by identifying key actions and design criteria to strengthen our buildings from the forces that might be anticipated in a terrorist assault. -
Application of Gaussian Bayes Classifier to Differentiate Chlorine-Based Chemical Agents
INL/EXT-20-57785 Application of Gaussian Bayes classifier to differentiate chlorine-based chemical agents Dongwon Lee Brian Bucher Ken Krebs Ed Seabury Jason Wharton April 7, 2020 The INL is a U.S. Department of Energy National Laboratory operated by Battelle Energy Alliance DISCLAIMER This information was prepared as an account of work sponsored by an agency of the U.S. Government. Neither the U.S. Government nor any agency thereof, nor any of their employees, makes any warranty, expressed or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness, of any information, apparatus, product, or process disclosed, or represents that its use would not infringe privately owned rights. References herein to any specific commercial product, process, or service by trade name, trade mark, manufacturer, or otherwise, does not necessarily constitute or imply its endorsement, recommendation, or favoring by the U.S. Government or any agency thereof. The views and opinions of authors expressed herein do not necessarily state or reflect those of the U.S. Government or any agency thereof. INL/EXT-20-57785 Application of Gaussian Bayes classifier to differentiate chlorine-based chemical agents D. Lee B. Bucher K. Krebs E. Seabury J. Wharton April 7, 2020 Idaho National Laboratory Nuclear Nonproliferation Division Idaho Falls, Idaho 83415 http://www.inl.gov Prepared for the U.S. Department of Energy Office of National Nuclear Security Administration Under DOE Idaho Operations Office Contract DE-AC07-05ID14517 ABSTRACT The Portable Isotopic Neutron Spectroscopy (PINS) is a commercialized system developed by Idaho National Laboratory (INL) to examine chemical warfare agents (CWA) non-destructively, utilizing Prompt Gamma Neutron Activation Analysis (PGNAA) techniques. -
Conflict by the Numbers: the Story of Conflict Through Mathematics
CHAPTER∏ 1 CONFLICT BY THE NUMBERS: THE STORY OF CONFLICT THROUGH MATHEMATICS Conflict is part of our everyday lives. It is everywhere. When people think of the word conflict, they often think of war. War is indeed a conflict, but it isn’t the only one. Conflicts range from person vs. self to society vs. society. Conflict could be destructive, but it can also be positive. Math and science are subjects that usually have a right or wrong answer. They aren’t anything like English or history where everything is elaborate. Math and science are concise, but they can like history or English, tell stories. Math and science are able to prove theories, make sense out of things and create evidence that can help to tell a story of conflict. ∏SECTION 1 History/Background of Mustard Gas History Uses Mustard gas was possibly discovered first by Cesar-Mansuete Despretez in Mustard gas was used in chemical warfare. It was used as a weapon by 1822. Despretez, however described the reaction of sulfur dichloride and dispensing it into the air as a vapor. It causes ill effects and it is an ethylene, but never described the harmful affects mustard gas has, therefore incapacitating agent. this discovery is not certain. This situation repeated itself in 1854, when Alfred Symptoms Riche didn’t describe the affects of mustard gas, making his Skin: redness and itching of the skin may occur 2 to 48 hours after exposure discovery doubtful as well. and change eventually to yellow blistering of the skin. However in 1860, Frederick Eyes: irritation, pain, swelling, and tearing may occur within 3 to12 hours of a Guthrie noted the irritating mild to moderate exposure. -
Organization and ELISA-Based Results of the First Proficiency Testing to Evaluate the Ability of European Union Laboratories To
toxins Article Organization and ELISA-Based Results of the First Proficiency Testing to Evaluate the Ability of European Union Laboratories to Detect Staphylococcal Enterotoxin Type B (SEB) in Buffer and Milk Yacine Nia 1,†, Mélanie Rodriguez 1,†, Reinhard Zeleny 2, Sabine Herbin 1, Frédéric Auvray 1, Uwe Fiebig 3, Marc-André Avondet 4, Amalia Munoz 2 and Jacques-Antoine Hennekinne 1,* 1 Laboratory for food safety, ANSES, Université Paris-Est, Maisons-Alfort F-94700, France; [email protected] (Y.N.); [email protected] (M.R.); [email protected] (S.H.); [email protected] (F.A.) 2 Joint Research Centre, Directorate for Health, Consumers and Reference Materials, European Commission, Retieseweg 111, Geel 2440, Belgium; [email protected] (R.Z.); [email protected] (A.M.) 3 Centre for Biological Threats and Special Pathogens Biological Toxins, Robert Koch Institute, Berlin 13353, Germany; [email protected] 4 LABOR SPIEZ, Eidgenössisches Departement für Verteidigung, Bevölkerungsschutz und Sport VBS Bundesamt für Bevölkerungsschutz BABS, Spiez 3700, Switzerland; [email protected] * Correspondence: [email protected]; Tel.: +33-1-49772624; Fax: +33-1-49772650 † These authors contributed equally to this work. Academic Editors: Andreas Rummel and Brigitte G. Dorner Received: 1 June 2016; Accepted: 31 August 2016; Published: 13 September 2016 Abstract: The aim of this work was to organize the first proficiency test (PT) dedicated to staphylococcal enterotoxin B (SEB) detection in milk and buffer solutions. This paper describes the organization of the PT trial according to EN ISO 17043 requirements. Characterization of the SEB stock solution was performed using SDS-PAGE and SE-specific ELISA, and amino acid analysis was used to assign its protein concentration. -
Website Chlorine Pwdr Sugar Water Phosgene Tear
Phosgene 2 Gases 44P make Hydrogen website Tear Gas,2 KCN 2, make somoom Chemical Agents Chlorine pwdr Ricin CHLORINE,2 Sugar water Phosgene Phosgene, also known as carbonic dichloride, colorless, extremely toxic gas of formula COCl2 with an unpleasant, irritating odor at high concentrations. It is prepared by the reaction of carbon monoxide with chlorine in the presence of a catalyst. Phosgene is poisonous in concentrations above 50 parts per million of air, and if inhaled, it causes severe and often fatal edema of the lungs within a few hours. It was used in World War I as a poison gas but today is used principally as an intermediate in the synthesis of organic compounds, including carbonic esters, isocyanates, polyurethanes, and dyes. Phosgene is 3.43 times heavier than air; the gas melts at -118° C (-180.4° F) and boils at 8.3° C (46.9° F). Look here Chemical war section. Tear Gas I INTRODUCTION Tear Gas, chemical substance that produces a primary physical effect of stinging or tearing eyes. Tear gas also irritates other mucous membranes and causes choking and coughing. People exposed to higher concentrations may experience burning, itching, or even blistering skin. As a form of riot control, police often use clouds of tear gas to break up crowds of people. A rifle-fired grenade or a thrown canister usually delivers tear gas, but smaller hand- held spray devices also exist. Tear gas may also be used to force the surrender of fugitives hiding in a building. Dogs and horses are relatively unaffected by tear gas, so they can add to the riot-control effect of the gas. -
Chemical and Biochemical Non-Lethal Weapons Political and Technical Aspects
SIPRI Policy Paper CHEMICAL AND 23 BIOCHEMICAL November 2008 NON-LETHAL WEAPONS Political and Technical Aspects ronald g. sutherland STOCKHOLM INTERNATIONAL PEACE RESEARCH INSTITUTE SIPRI is an independent international institute for research into problems of peace and conflict, especially those of arms control and disarmament. It was established in 1966 to commemorate Sweden’s 150 years of unbroken peace. The Institute is financed mainly by a grant proposed by the Swedish Government and subsequently approved by the Swedish Parliament. The staff and the Governing Board are international. The Institute also has an Advisory Committee as an international consultative body. The Governing Board is not responsible for the views expressed in the publications of the Institute. GOVERNING BOARD Ambassador Rolf Ekéus, Chairman (Sweden) Dr Willem F. van Eekelen, Vice-Chairman (Netherlands) Dr Alexei G. Arbatov (Russia) Jayantha Dhanapala (Sri Lanka) Dr Nabil Elaraby (Egypt) Rose E. Gottemoeller (United States) Professor Mary Kaldor (United Kingdom) Professor Ronald G. Sutherland (Canada) The Director DIRECTOR Dr Bates Gill (United States) Signalistgatan 9 SE-169 70 Solna, Sweden Telephone: +46 8 655 97 00 Fax: +46 8 655 97 33 Email: [email protected] Internet: www.sipri.org Chemical and Biochemical Non-lethal Weapons Political and Technical Aspects SIPRI Policy Paper No. 23 ronald g. sutherland STOCKHOLM INTERNATIONAL PEACE RESEARCH INSTITUTE November 2008 All substances are poisons; there is none which is not a poison. The right dose differentiates a poison and a remedy. Paracelsus (1493–1541) © SIPRI 2008 All rights reserved. No part of this publication may be reproduced, stored in a retrieval system or transmitted, in any form or by any means, without the prior permission in writing of SIPRI or as expressly permitted by law. -
Chemical Weapons Technology Section 4—Chemical Weapons Technology
SECTION IV CHEMICAL WEAPONS TECHNOLOGY SECTION 4—CHEMICAL WEAPONS TECHNOLOGY Scope Highlights 4.1 Chemical Material Production ........................................................II-4-8 4.2 Dissemination, Dispersion, and Weapons Testing ..........................II-4-22 • Chemical weapons (CW) are relatively inexpensive to produce. 4.3 Detection, Warning, and Identification...........................................II-4-27 • CW can affect opposing forces without damaging infrastructure. 4.4 Chemical Defense Systems ............................................................II-4-34 • CW can be psychologically devastating. • Blister agents create casualties requiring attention and inhibiting BACKGROUND force efficiency. • Defensive measures can be taken to negate the effect of CW. Chemical weapons are defined as weapons using the toxic properties of chemi- • Donning of protective gear reduces combat efficiency of troops. cal substances rather than their explosive properties to produce physical or physiologi- • Key to employment is dissemination and dispersion of agents. cal effects on an enemy. Although instances of what might be styled as chemical weapons date to antiquity, much of the lore of chemical weapons as viewed today has • CW are highly susceptible to environmental effects (temperature, its origins in World War I. During that conflict “gas” (actually an aerosol or vapor) winds). was used effectively on numerous occasions by both sides to alter the outcome of • Offensive use of CW complicates command and control and battles. A significant number of battlefield casualties were sustained. The Geneva logistics problems. Protocol, prohibiting use of chemical weapons in warfare, was signed in 1925. Sev- eral nations, the United States included, signed with a reservation forswearing only the first use of the weapons and reserved the right to retaliate in kind if chemical weapons were used against them. -
Chemical Terrorism Fact Sheet Mustard Agent Eye Lesions Vesicants (Blistering Agents) - Mustard Agents Photo Courtesy Department of Defense
Chemical Terrorism Fact Sheet Mustard Agent Eye Lesions Vesicants (Blistering Agents) - Mustard Agents Photo Courtesy Department of Defense Protective Equipment/Detection Chemical Overview The mustards can penetrate cell membranes in tissues and numerous materials: Mustard agents, sulphur mustard (HD) woods, leather, rubber, plants, etc. Since ordinary clothing and surgical gear offer and nitrogen mustard (HN), are known little or no protection, special equipment including a respirator, NBC protective suit, as vesicant, or blistering, agents. Sulphur gloves and overboots are required. Due to the slow absorption of mustard by many mustard, first synthesized in 1822, is materials, protective equipment must be changed regularly. best known as the mustard gas of WWI where it received its name because of its garlicky, mustard odor. Mustard (HD) Mustards form, under certain conditions, colored complexes with para- is 2,2’-di(chloro-ethyl)-sulphide. In nitrobenzpyridine, making it possible to detect minute amounts. Readily available 1935, it was discovered that the vesicant single and three-color detector papers will detect liquid agent. Monitoring devices properties persisted when the sulphur for local contamination and water testing kits are also available. Mass spectrometric atom was substituted by nitrogen. There and immunoassay methods applied to blood samples, as well as urinary thiodiglycol are three nitrogen mustard agents – N- ethyl-2,2’di(chloroethyl) amine, or HN1, levels, can now be used to confirm exposure. N methyl-2,2’di(chloroethyl) amine, or HN2, and 2,2’, 2’’tri(chloroethyl) amine, or HN3 – of which only HN3 is likely to be used in war. HD and HN3 are the most feared vesicants historically, because of their chemical sta- Decontamination bility, their persistency in the field, their Skin – Decontaminate skin by physical adsorption or by the combination of physical ability to attack eyes, mucous membranes, adsorption and chemical inactivation. -
Chemical Weapons
POSTNOTE Number 596 March 2019 Chemical Weapons Overview ◼ Chemical weapons use toxic chemicals for deliberate harm to humans or animals. ◼ Chemical weapons attacks take many forms, depending on the chemical agent, method of exposure, and the target. ◼ Many toxic chemicals that could be used as weapons also have legitimate uses. ◼ The Chemical Weapons Convention has driven efforts for disarmament and control. Chemical weapons are prohibited, but recent ◼ The Organisation for the Prohibition of chemical weapons attacks in Malaysia, Syria, Chemical Weapons oversees disarmament, Iraq and the UK have raised concerns about their use. This POSTnote gives an overview of monitors chemicals and investigates alleged chemical weapons, including modes of delivery attacks. and effects on human health. It also examines ◼ Incident response involves many agencies the status of international disarmament, and working to treat victims, minimise impacts, defence against chemical weapons in the UK. and support investigation. Background Chemical Weapons Defence Centre at Porton Down, which ‘Chemical weapons’ refers to the use of toxic chemicals to will include new chemical analysis laboratories.17 It also inflict deliberate harm to humans or animals. Chemical announced £11m to strengthen the UK’s response to weapons were first used on a large scale during World War chemical weapons attacks in March 2019.18 I, causing an estimated 90,000 deaths and 1.3 million Chemical weapons attacks can occur in different contexts, casualties.1,2 They are prohibited by the -
Harvard University Center for Nanoscale Systems Safety Manual
Harvard University Center for Nanoscale Systems Safety Manual EMERGENCY CONTACTS FIRE OR MEDICAL ........................................................................................... 911 PUBLIC SAFETY HARVARD UNIVERSITY POLICE .................................................... 617-495-1212 CHEMICAL SPILLS OR GAS LEAKS OPERATIONS CENTER ................................................................... 617-495-5560 If Time Permits, Contact the Staff John SWeeney – EHS ................................................................................... 5-1290 JD Deng – Cleanroom .................................................................................. 5-3396 David Bell – Imaging/Materials .................................................................... 6-6794 SOP077_SafetyManual_2018_10_31l.doc 1 / 43 10/31/18 Contents 1 Emergency Response Checklist ....................................................................................... 3 2 Responsibilities ................................................................................................................. 4 3 Purpose ............................................................................................................................ 4 4 Scope ............................................................................................................................... 4 5 Emergency & Personal Protective Equipment .................................................................. 5 6 General Safety Requirements .......................................................................................