2015 Cures Through Research Board of Directors

ANNUAL REPORT 2015 CURES THROUGH RESEARCH BOARD OF DIRECTORS

OFFICERS Chairman Stephen A. Lieber

Vice President Suzanne Golden

Secretary John B. Hollister

Treasurer Arthur Radin, CPA

DIRECTORS Anne E. Abramson Donald M. Boardman J. Anthony Boeckh Susan Lasker Brody Paul T. Burke Bonnie D. Hammerschlag John Kennedy Harrison II Carole H. Mallement Milton Maltz Marc R. Rappaport Virginia M. Silver Kenneth H. Sonnenfeld, Ph.D., J.D. Barbara K. Streicker Barbara Toll Robert Weisman, Esq.

EX-OFFICIO President & CEO Jeffrey Borenstein, M.D.

President, Scientific Council Herbert Pardes, M.D.

PUBLICATION CREDITS Writers Lauren Duran Peter Tarr, Ph.D.

Editor Lauren Duran

Design Kim Howie

BRAIN & BEHAVIOR RESEARCH FOUNDATION TABLE OF CONTENTS

4 Our Global Footprint

6 Thank You from Our Leaders

8 15 Major Discoveries in 2015

18 2015 Investments in Research Grants

20 Distinguished Investigators

22 Independent Investigators

24 Young Investigators

29 Meet the Scientist Webinar Series

30 Our Scientific Council

32 Our New Scientific Council Members

38 Foundation Events

44 Parenting

48 Stories of Productive Lives

52 Donors

53 Research Partners Program

58 Donor Listings

64 Honor Tributes

66 Memorial Tributes

69 Community Partners

72 2015 Financial Summary

2015 Annual Report Our Global Footprint

“The reach of the Brain & Behavior Research Foundation’s Grants 529 Institutions (including subsidiaries and af liations) knows no borders. The impact of our effort is not only in the TOTAL NUMBER OF COUNTRIES TOTAL NUMBER OF STATES IN THE U.S. development of promising scientists, but also in the focus it brings to the challenge and urgent need of bringing hope and better lives 329 In the U.S. to all those living with mental illness.” HERBERT PARDES, M.D. President, Foundation Scientific Council 34 46 200 Outside of the U.S. Executive Vice Chairman of the Board of Trustees Including Washington, D.C. NewYork-Presbyterian Hospital

Institutions Added in 2015 Ghent University Italian Institute of Technology University of Vienna, Ferris University National Scienti c Council of Argentina (CONICET) Second University of Naples University of Cadiz University of Kansas 321 University of Rennes, University of Basque Country University of Trento 14 University of Tulsa 8 2 1 150 36 13 29 1 1 Grants 30 20 3

IN 2015 SINCE 1987 3 17 25 1 2 7 7 4175 4 Young Investigators Total Amount Awarded 712 Applications $342 Million 82 191 Awarded 1 179 New Grantees Total Grants Awarded 12 Prior Grantees 5,000+ In total 4,100+ In the U.S. 3 1 Independent Investigators 900+ Outside of the U.S. 1 315 Applications 1 40 Awarded 1 16 New Grantees 6 24 Prior Grantees

Distinguished Investigators GRANTS BY STATE SINCE 1987 181 Applications 60 15 Awarded New York: 757 California: 642 Massachusetts: 452 Maryland: 306 Connecticut: 302 Pennsylvania: 268 6 New Grantees Texas: 177 North Carolina: 153 Illinois: 113 2 9 Prior Grantees Georgia: 93 Michigan: 89 Tennessee: 87 Ohio: 82 Missouri: 58 Colorado: 49 Iowa: 49 Washington: 48 Wisconsin: 44 Virginia: 38 New Jersey: 35 Rhode Island: 34 Minnesota: 33 Indiana: 31 Oregon: 25 Florida: 25 South Carolina: 19 Washington D.C.: 18 2 Alabama: 16 New Hampshire: 16 New Mexico: 16 Louisiana: 15 Kentucky: 13 Utah: 13 Arizona: 10 Mississippi: 10 Oklahoma: 7 # Number of Grants in a Country Arkansas: 7 Nebraska: 6 Vermont: 5 Orange indicates a new institution Kansas: 4 Hawaii: 4 West Virginia: 4 was added in 2015 Maine: 1 Delaware: 1

Our Global Footprint

IN 2015 SINCE 1987 3 17 25 1 2 7 7 4175 4 Young Investigators Total Amount Awarded 712 Applications $342 Million 82 191 Awarded 1 179 New Grantees Total Grants Awarded 12 Prior Grantees 5,000+ In total 4,100+ In the U.S. 1 Independent Investigators 900+ Outside of the U.S. 1 315 Applications 1 40 Awarded 1 16 New Grantees 6 24 Prior Grantees

2015 Annual Report DEAR FOUNDATION SUPPORTERS

Beginning in 1987, long before the venture capital tech An independent measure of the success of our grants is in a boom and the Internet Bubble (1995–2000), the Brain & recent RAND Europe analysis of the global mental health Behavior Research Foundation was providing seed money to research funding landscape over the past five years. This neuroscientists to invest in “out of the box” research that the report found that we are the top non-government mental government and other sources were unwilling to fund. That health research funder mentioned in published articles. same year the Foundation awarded $250,000 in NARSAD Young Investigator Grants to its first 10 early career scientists The Foundation is a driving force in advancing what is known at $25,000 each to fund their promising research ideas. As of about mental illness and how to better treat, prevent and December 2015, we have awarded more than $342 million in ultimately cure it. A few examples of research progress in more than 5,000 grants, to more than 4,000 scientists in the 2015 include: United States and 34 other countries, in over 525 universities and medical centers. Gene Expression Analysis Points Toward Pathways Involved in Major Depression The $342 million in grants awarded by the Foundation since 1987 has resulted in over $3 billion in additional research Dr. Patrick Sullivan (2014 Lieber Prizewinner and 2010 funding for these scientists. Distinguished Investigator) and Dr. Dorret Boomsma (2011 Distinguished Investigator) identified 119 genes whose activity We can measure our success through the multiplier effect. differs significantly in people with major depressive disorder. A survey of our grantees revealed: Whether stemming from inherited genetic factors and/or environmental influences, these gene expression changes • NARSAD Grants increase researchers ability to help point scientists toward biological pathways likely to be secure additional grant support involved in the disorder. The study also pointed to 19 genes • NARSAD Grants result in subsequent funding whose expression was more likely to have returned to normal (federal and private) of at least 10 times the amount if an individual had recovered from an earlier depression. invested by the Foundation Hopeful News on Comprehensive Team Treatment Government budgets are declining for basic research and of Early Psychosis many major pharmaceutical companies are backing away from neuropsychiatric research and development. Dr. Nina Schooler (Scientific Council Member and 1998 The Foundation is unique in that it relies on private Distinguished Investigator), Dr. Kim Mueser (2003 contributions of individuals and family foundations to Distinguished Investigator and 1988 Young Investigator) accelerate funding of the most promising brain research to and five other grant recipients, along with other colleagues, find better treatments and cures for mental illness. We seek demonstrated that early intervention and coordinated team answers in understanding how the brain functions and can care can make a real, positive difference in outcomes for malfunction; answers in developing preventative and early first-episode psychosis patients. Over two years, the team intervention techniques and answers in finding improved treated 223 patients with a protocol called NAVIGATE, a treatments for those whose illness has progressed. In 2015, first-episode intervention stressing low-dose antipsychotic the Foundation awarded a total of $18.5 million to our Young medications; cognitive behavioral therapy to support Investigator, Independent Investigator and Distinguished resiliency and illness self-management skills; family Investigator Grantees. psychoeducation and support; and provided employment and educational opportunities. The better outcomes suggest No other organization outside of the federal government has the importance of early and coordinated intervention after a funded the number of mental health research grants that the first psychotic episode. Foundation has—or been responsible for more breakthroughs in the field.

BRAIN & BEHAVIOR RESEARCH FOUNDATION New Compounds Show Promise in Treating Our mission to alleviate the suffering of mental illness Schizophrenia Symptoms through scientific advances and understanding is based upon our steadfast commitment to patients, family members and Dr. Marc Caron, (Scientific Council Member, 2013 Lieber friends. We believe that this past year more people were able Prizewinner and 2005 Distinguished Investigator) found to live happy, productive lives. This progress could not have two new small-molecule drugs tested in mice alleviated some been accomplished without the extraordinary dedication of symptoms of schizophrenia-like behaviors, including social our 165-member Scientific Council. Their volunteer effort is avoidance and cognitive performance. The team found that at the heart of the Foundation’s achievements and the basis for drugs called UNC9975 and UNC9994 influence the beta- its success in continuing to make advances in research. arrestin communication pathway and reduced hyperactive movements, improved memory for novel stimuli, and made But more still needs to be done and we are poised and ready. the test mice more social. The work shows that hitting other With your ongoing commitment we will continue to invest your pathways in schizophrenia has the potential to treat symptoms contributions into promising ideas that get results. Results that in more individualized, fine-tuned ways. in turn will improve lives. Thank you for your support.

With sincere thanks and regards, We Support Scientists and Research in Its Early Stages

We understand that some outcomes may be groundbreaking, like our early support of the use of Clozaril for schizophrenia, transcranial magnetic stimulation for treatment resistant depression, deep brain stimulation for depression, and optogenetics, the breakthrough technology that uses light to control activity patterns in the brain. But all research generates new findings that can help advance the understanding of the brain. Foundation funded grants are like venture capital support for our scientists. JEFFREY BORENSTEIN, M.D. Most of our grants go to Young Investigators. By funding President and CEO these scientists, you are supporting a career in brain research. We have a unique arrangement with the universities and institutions in which no overhead costs are taken from the grants given to our Young Investigators—every dollar goes to scientific research. With our Independent Investigators and Distinguished Investigators, institutions may only take up to eight percent maximum per year of overhead costs.

Because of the generous support of two family foundations STEPHEN A. LIEBER which cover the Foundation’s operating expenses, 100 percent of your contributions for research are invested in our grants Chair, Board of Directors leading to advances and breakthroughs in brain and behavior research. Your donations have a tremendous impact.

No other organization outside of the federal government has funded the number of mental health research grants that the Foundation has—or been responsible HERBERT PARDES, M.D. for more breakthroughs in the field. President, Scientific Council

2015 Annual Report 15 MAJOR DISCOVERIES in 2015

2015 was an exciting year in brain and behavior research thanks to you and the many others who generously support our grantees 2015and the groundbreaking discoveries they are making.

BRAIN & BEHAVIOR RESEARCH FOUNDATION Listed in Order of Publication

Watching Patient-Derived Long-Term Effects of Marijuana Estrogen Drug Improves Cognition Brain Cells Take Shape in the Lab on the Brain in Schizophrenia Patients 1 6 11 Reveals Autism Defect

Lithium Linked to Lower Incidence Gene Expression Analysis Omega-3 Supplements of Dementia in Older People Points Toward Pathways Involved Linked to Reduced Risk of 2 with Bipolar Disorder 7 in Major Depression 12 Developing Psychosis

Parent’s History of Suicide Non-Invasive Stimulation Reworks Size of Brain Structure May Predict Attempts Helps Predict Suicide Brain Waves, Improves Cognition Effectiveness of Ketamine 3 Attempts in Their Children 8 13

Combined Drug Treatment Improved New Compounds Show Promise in Distinguishing Childhood and Adult 4 Results in Geriatric Depression 9 Treating Schizophrenia Symptoms 14 Forms of ADHD

Omega-3 Relieves Depression Drug Helps Mice Respond Hopeful News on Comprehensive Symptoms in People Normally to Fear Team Treatment of Early Psychosis 20155 with Bodily Inflammation 10 After Traumatic Experience 15

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BASIC RESEARCH: ADDICTION BASIC RESEARCH/TREATMENT: BIPOLAR DISORDER Vince D. Calhoun, Ph.D. Long-Term Effects of Marijuana Tobias Gerhard, Ph.D. The Mind Research Network on the Brain Rutgers University Lithium Linked to Lower 2004 NARSAD 2010 NARSAD Incidence of Dementia in Older Young Investigator Grant Young Investigator Grant Marijuana use is on the rise People with Bipolar Disorder

nationally, a fact that is not *Team included: Davangere surprising in view of recent efforts P. Devanand, M.D., 1997 People with bipolar disorder are to legalize the drug in several states. Scientific Council Independent Investigator, thought to be more likely to member Nora Volkow, Director of the National Institute on 1987 Young Investigator develop dementia than those who and Mark Olfson, M.D., Drug Abuse in Washington, D.C., has repeatedly warned M.P.H., 2005 Distinguished don’t have the disorder. Hence of the harmful impact of heavy marijuana use on the Investigator the importance of a finding by brain, particularly among those who use the drug regularly Tobias Gerhard, Ph.D., of Rutgers beginning at a very young age, and among those who happen University, and colleagues*, who to be at elevated risk for psychotic illness. reported in 2015 that regular treatment with lithium may reduce the risk of dementia in Scientific studies of the long-term effects of marijuana on the people with bipolar disorder. brain have generated controversy, providing an inconsistent picture in part due to variations in research methods. Lithium is an effective mood stabilizer for people with With this in mind, a research team that included Vince D. bipolar disorder. It was approved by the U. S. Food and Calhoun, Ph.D., recipient of a NARSAD Young Investigator Drug Administration in the 1970s, but its use has declined grant in 2004, set out to perform a comprehensive study in the last 20 years as alternative treatments, such as the to characterize brain alterations associated with chronic anticonvulsants valproic acid (Depakote and others) and marijuana use. lamotrigine (Lamictal), have become available.

The team, led by Francesca Filbey, Ph.D., of the University In the January 22, 2015 issue of the British Journal of of Texas at Dallas, measured the volume of the brain’s Psychiatry Dr. Gerhard and team set forth the results of their grey matter brain-wide with structural magnetic resonance analysis of data from more than 40,000 adults. They had imaging, as well as abnormal grey matter regions and the examined Medicare and Medicaid records of patients over integrity of the brain’s white matter via diffusion tensor 50 years of age diagnosed with bipolar disorder. For those imaging. Subjects included 48 marijuana users and 62 who took lithium more than 300 days during the prior year, matched control subjects who did not use the drug. dementia occurred less frequently than for those who took the drug less frequently or not at all during the same period. Reporting in the Proceedings of the National Academy of Using lithium sporadically or intermittently did not affect the Sciences, the team found changes in grey matter volume and incidence of dementia, nor did treatment with anticonvulsants potential functional abnormalities in grey matter as well in regardless of how often they were used. connections within white matter. Specifically, they found that chronic use reduces grey matter volume in the brain’s Lithium blocks an enzyme called GSK3, known to contribute orbitofrontal cortex; increases structural and functional to Alzheimer’s disease. Scientists have suspected that the drug connectivity; and leads to neural alterations that are affected might protect broadly against neurodegeneration, but clinical by the age of onset and duration of use. evidence has been inconsistent. The Gerhard team’s analysis is the largest to date of dementia among people taking lithium These findings suggest chronic marijuana use results in to treat bipolar disorder. According to Dr. Gerhard, the complex neuroadaptive processes. Future long-term studies findings “strengthen the hypothesis that lithium exerts a will be needed to determine whether there is a reversion to protective effect on the development of dementia in patients normal following prolonged abstinence from marijuana use. with bipolar disorder, and support clinical trials to further investigate the neuroprotective effects of lithium.”

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PREVENTION/DIAGNOSIS: SUICIDAL NEXT-GENERATION TREATMENTS: J. John Mann, M.D. BEHAVIOR Helen Lavretsky, M.D. DEPRESSION (GERIATRIC)

Columbia University Parent’s History of Suicide Semel Institute, University of Combined Drug Treatment California, Los Angeles Scientific Council Member Attempts Helps Predict Suicide Improved Results 1999 NARSAD 2008 NARSAD Distinguished Attempts in Their Children Young Investigator Grant in Geriatric Depression Investigator Grant As public health experts debate the Helen Lavretsky, M.D., of the *Team included: David A. Brent, M.D., best ways to reduce suicides—the University of Southern California, was first author on an 2001 Distinguished 10th leading cause of death in important paper reporting results of the first comprehensive and Investigator, the United States—new research well-controlled trial to find out if the drug methylphenidate John G. Keilp, Ph.D., 1998 and 1996 Young by Foundation Scientific Council (Ritalin) can enhance clinical and cognitive outcomes in Investigator and member and 2008 Distinguished patients with geriatric depression. Their results appeared in Nadine M. Melhem, Ph.D., Investigator grantee J. John The American Journal of Psychiatry on February 13, 2015. 2013 and 2004 Young * Investigator Mann, M.D., and colleagues calls attention to the importance of early The research team specifically set out to discover whether intervention based on long-term methylphenidate improved patients’ response to the risk factors. widely prescribed antidepressant citalopram (Celexa). They conducted a 16-week randomized double-blind placebo- In a study published in the February 2015 issue of JAMA controlled trial for geriatric depression in 143 older Psychiatry, Dr. Mann and colleagues probed the extent to outpatients diagnosed with major depression. They compared which suicidal behavior in a parent gets passed on to children. results in three treatment groups of equal size: one group The team tracked 701 children of 334 people diagnosed with received methylphenidate plus placebo; a second, citalopram mood disorders for an average of six years to identify factors plus placebo; and a third, citalopram plus methylphenidate. that predicted suicide attempts among the children. Daily doses ranged from 20 mg to 60 mg for citalopram The investigators found that having a parent who had and from 5 mg to 40 mg for methylphenidate. All groups attempted suicide made it nearly five times more likely that showed significant improvement in depression severity and in one of their children would make an attempt. It has been cognitive performance. However, the improvement was more known that both genetic and non-genetic factors related to prominent in the citalopram plus methylphenidate group the predisposition for suicidal behavior, or to psychiatric compared with the other two groups. illnesses that trigger suicidal behavior, are transmitted in families. This study sought to identify the factors responsible Additionally, the rate of improvement in the citalopram plus for familial transmission. methylphenidate group was significantly higher than that in the citalopram plus placebo group in the first four weeks of Suicide attempts were more likely among those children who, the trial. The groups did not differ in cognitive improvement like their parents, were diagnosed with a mood disorder such or number of side effects. as major depression or bipolar disorder. Such diagnoses are typically present at least a year before the first attempt. Most Combined treatment with citalopram and methylphenidate people diagnosed with depression do not attempt suicide demonstrated an enhanced clinical response profile in because they do not have a predisposition to suicidal behavior. mood and well-being, as well as a higher rate of remission, Independent of family history of depression, impulsive and compared with either drug alone. All treatments led aggressive behavioral traits among the children also made it to an improvement in cognitive functioning, although more likely that they will attempt suicide. augmentation with methylphenidate did not offer additional benefits, the team reported. The findings highlight the importance of three long-term risk factors a family history of suicide attempts, a family history of mood disorders, and a personal history of impulsive aggression.

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NEXT-GENERATION THERAPY: NEXT-GENERATION THERAPY: Mark H. Rapaport, M.D. DEPRESSION Cynthia S. Weickert, Ph.D. SCHIZOPHRENIA

Emory University School Omega-3 Relieves Depression University of New South Wales, Estrogen Drug Improves of Medicine Symptoms in People with Bodily Australia Cognition in Schizophrenia 1999 NARSAD Independent 2004 NARSAD Independent Investigator Grant Inflammation Investigator Grant Patients 2001, 1999 NARSAD In the March 24, 2015 issue of Young Investigator Grant A team led by University of New Molecular Psychiatry, Foundation South Wales researcher Cynthia Grantees found that certain fatty *Team included: S. Weickert, Ph.D., discovered acids, including omega-3, worked Rhoshel K. Lenroot, M.D., in 2015 that the estrogen-like 2003 Young Investigator and better to reduce symptoms of Ans Vercammen, Ph.D., 2010 drug raloxifene—often prescribed Andrew A. Nierenberg, M.D. depression in people with signs Young Investigator, along with for osteoporosis—can improve of elevated bodily inflammation, Jayashri Kulkarni, MBBS, attention and memory in men and Massachusetts General Hospital MPM, FRANZCP, Ph.D., 2000 compared to people without those Independent Investigator, and women with schizophrenia. Scientific Council Member signs. The finding supports the use her husband and first author 2013 Foundation Colvin of fatty acids to treat some people Thomas W. Weickert, Ph.D. A growing body of evidence suggests Prizewinner with depression, although the that estrogen plays a beneficial 2003 NARSAD Distinguished research needs to be replicated in a role in the brain, supporting Investigator Grant trial with many more participants. growth and protecting neurons 2000 NARSAD Independent from damage. From work supported by her NARSAD Young Investigator Grant Omega-3 fatty acids are found in Investigator Grants, Dr. Weickert and her colleagues* found some green vegetables, vegetable that brain estrogen receptors are altered in some people with oils, and fatty fish. They are schizophrenia, blunting their ability to respond to estrogen’s recommended by some physicians beneficial effects. Raloxifene stimulates estrogen receptors as a way to protect against heart and can help overcome a blunted estrogen response. The drug disease and stroke. In this study, also stimulates estrogen receptors in the brain and may guard 155 people with major depressive against memory loss in aging, making it potentially useful for David Mischoulon, M.D., Ph.D. disorder were given either a placebo cognitive problems in schizophrenia patients. Massachusetts General or one of two types of omega-3s: Hospital eicosapentaenoic acid (EPA) or Dr. Weickert and colleagues reported May 18, 2015 in the 2000, 1998 NARSAD docosahexaenoic acid (DHA), over journal Molecular Psychiatry on the drug’s effect in 98 people Young Investigator Grant an 8-week period. They were also diagnosed with schizophrenia or schizoaffective disorder (which tested to see whether they had combines symptoms of schizophrenia and a mood disorder). any of 10 chemicals in their blood All of the patients received a daily dose of raloxifene along indicating high inflammation levels. People with one or more with their usual antipsychotic medications in one phase of the indicators of high inflammation showed a greater reduction clinical trial and a placebo in another phase. in depressive symptoms if taking EPA compared with DHA. But people who showed no indicators of high inflammation After the first six-week period, patients taking raloxifene had responded less to EPA than either DHA or placebo, indicating improved scores on memory and attention compared to those that taking EPA is not always helpful. While omega-3s like taking placebo. Raloxifene treatment significantly improved EPA with anti-inflammatory properties may help relieve attention and thought processing speed. It did not reduce symptoms in people whose depression is associated with the severity of schizophrenia symptoms any more than the inflammation, omega-3s may in fact interfere with depression placebo did, but both groups showed fewer symptoms overall treatment in people whose depression has other causes. during the study, and none of the patients had severe side effects from the treatment.

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BASIC RESEARCH: DEPRESSION NEXT-GENERATION THERAPY: Patrick F. Sullivan, M.D., Sohee Park, Ph.D. SCHIZOPHRENIA FRANZCP Gene Expression Analysis Points Toward Pathways Involved in Vanderbilt University Non-Invasive Stimulation University of North Carolina 2012 NARSAD Distinguished School of Medicine and the Major Depression Reworks Brain Waves, Investigator Grant Karolinska Institute Improves Cognition 2004 NARSAD Independent 2014 Lieber Prizewinner While there is good evidence Investigator Grant 2010 NARSAD Distinguished that genetics influences a person's Transcranial direct current 1996, 1991 NARSAD Investigator Grant likelihood of developing major Young Investigator Grant stimulation (tDCS) is an affordable depression, scientists have only just and portable way to stimulate begun to uncover specific genetic the brain. It can help induce variations that may increase risk. normal neural activity and make In a study published May 26, 2015 thought processes more flexible in people with schizophrenia, in Molecular Psychiatry, scientists according to a study published online June 29, 2015 in led by Patrick F. Sullivan, M.D., at Proceedings of the National Academy of Sciences. Dorret I. Boomsma, Ph.D. the University of North Carolina

VU University Amsterdam, School of Medicine, sought out The study suggests a drug-free and safe way of treating Netherlands depression-relevant genes by debilitating cognitive problems, for which antipsychotics are 2011 NARSAD Distinguished measuring and comparing gene not completely effective. Investigator Grant activity in the cells of more than 1,800 individuals. To date, this Among the cognitive impairments present in schizophrenia is the largest analysis of gene are problems with learning from mistakes and adapting to expression in people with major depression. changing conditions. In lab tests, people with schizophrenia may stick with wrong answers or strategies even if the outcome Using blood samples collected as part of the Netherlands is not successful. They do not tend to slow down to reconsider Study of Depression and Anxiety, Dr. Sullivan and Dr. Dorret their responses after making a mistake. These difficulties can Boomsma measured gene expression in the cells of 882 people interfere with learning at all levels. with depression, 635 people who were not experiencing major depression at the time of the study but had in the past, as well “In order to optimally interact with our complicated as a control group of 331 people who reported no current or environment, we constantly adjust our behavior,” explains past depression. Dr. Sohee Park. "People with schizophrenia have difficulty adjusting. This results in inflexibility of actions and thoughts. They found 119 genes whose activity differed between the Importantly, they may not even notice their errors when they control group and people with current depression. Many make them.” of these were genes that affect immune function. This was consistent with other research suggesting a link between the Twenty minutes of low-voltage tDCS applied to the scalp immune system and mood disorders. over the medial prefrontal cortex improved error-monitoring and accuracy in a test of adaptive control in people with Two years after their initial analysis, Dr. Sullivan and schizophrenia. After stimulation, specific brain waves colleagues collected additional data from a subset of the measured by scalp electrodes were observed to “normalize,” by people in the study. This enabled them to compare gene showing greater synchrony—in this respect more resembling activity between those who had recovered from their patterns seen in healthy controls. depression and those who didn't. Of the 119 depression- associated genes they had already identified, they found Scientific Council Member Cameron Carter, M.D. wrote: 19 genes whose activity also correlated with changes in “these findings reinforce our growing understanding that the depression—in these 19 genes, expression was more likely disordered brain is not locked away inside the skull but is to have returned to normal among those who had recovered indeed within our reach and accessible for neuromodulation.” from their depression.

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NEXT-GENERATION THERAPY: NEXT-GENERATION THERAPY: Marc G. Caron, Ph.D. SCHIZOPHRENIA Kerry J. Ressler, M.D., Ph.D. ANXIETY, POST-TRAUMATIC STRESS DISORDER Duke University New Compounds Show Promise McLean Hospital, Harvard Medical School Scientific Council Member in Treating Schizophrenia Drug Helps Mice Respond Scientific Council Member 2013 Lieber Prizewinner Symptoms Normally to Fear After Traumatic 2005, 2002 NARSAD 2005 NARSAD Distinguished Experience Young Investigator Grant Investigator Grant Two new small-molecule drugs tested in mice can alleviate some In treating post-traumatic stress symptoms of schizophrenia- disorder (PTSD), the goal is to find like behaviors, including ways to help patients “extinguish” abnormal and exaggerated movement abnormalities, social avoidance, and cognitive fear responses that can continue long after a traumatic event. performance. This preliminary success in work toward better In a new study with mice, Kerry J. Ressler, M.D., Ph.D., and treatments for schizophrenia, was reported July 1, 2015 in his colleagues showed that treatment with the corticosteroid Neuropsychopharmacology. drug dexamethasone can help the animals lose their PTSD- related fear response, possibly through the drug’s effects on a Currently used antipsychotic drugs block the dopamine gene called Fkbp5. D2 receptor, an important communication port for some neurons in the brain. These drugs are used mainly to treat The findings, published online July 15, 2015 in the journal schizophrenia’s “positive” symptoms such as delusions and Neuropsychopharmacology, may reveal an opportunity to hallucinations. They are less effective, and often ineffective, halt the disorder soon after people experience a traumatic in treating “negative” symptoms such as a lack of pleasure event. Dr. Ressler, of Emory University, who in 2002 and in everyday life, or concentration and memory problems 2005 received NARSAD Young Investigator Grants, and (schizophrenia’s “cognitive symptoms”). colleagues, trained a group of mice using sounds and mild electrical shocks to learn and then to inhibit a specific fear. The research team, which included Marc G. Caron, Animals that had experienced a traumatic event before the Ph.D., and William C. Wetsel, Ph.D., a 1998 NARSAD fear training were more likely to inhibit or extinguish the Independent Investigator, both of Duke University Medical fear if they were given a low dose of dexamethasone four Center, decided to look for drug candidates that would block hours beforehand to suppress the internal stress response. signaling pathways related to the dopamine D2 receptor that The fear was also more likely to remain “extinguished” 24 are not affected by existing antipsychotic medicines, in the hours later in those same animals. hope that this might reveal novel ways to treat a wider variety of schizophrenia symptoms. Dr. Ressler and colleagues also showed that the dexamethasone dose affected how Fkbp5 is expressed in the They tested two dopamine D2 receptor-targeting compounds amygdala, a part of the brain involved in regulating fear called UNC9975 and UNC9994 that influence the beta- and anxiety. They suggest that dexamethasone may help to arrestin communication pathway. The research showed that extinguish fear learning after a trauma through its effects on the compounds could normalize schizophrenia-like symptoms Fkbp5, specifically in that gene’s role in helping regulate the in mice by reducing their hyperactive movements, improving response to stress. their memory for novel stimuli and making them more social around other mice. The study adds to the body of research implicating Fkbp5 in PTSD, including earlier reports by Dr. Ressler and others that The new compounds also produced a much lower level have indicated certain mutations in the gene may be related of catalepsy—a rigid muscle side effect of schizophrenia to whether childhood victims of trauma grow up to develop treatment—than traditional antipsychotic drugs. Targeting PTSD as adults. different pathways connected to the dopamine D2 receptors may facilitate treating patients in more individualized, fine- tuned ways.

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NEXT-GENERATION TECHNOLOGY/ NEXT-GENERATION TREATMENTS: Flora M. Vaccarino, M.D., Ph.D. BASIC RESEARCH: AUTISM Patrick McGorry, M.D., PSYCHOSIS, SCHIZOPHRENIA, Ph.D., FRCP, FRANZCP BIPOLAR DISORDER Yale University Watching Patient-Derived Brain University of Melbourne, 2011 NARSAD Distinguished Cells Take Shape in the Lab Omega-3 Supplements Linked to Australia Investigator Grant Reduced Psychosis Risk Reveals Autism Defect 2015 Lieber Prizewinner 2003, 2000, 1993, 1990 NARSAD Young 1998 NARSAD Distinguished Investigator Grant Scientists using a new technology Investigator Grant The Foundation’s 2015 Lieber that involves reprogramming Prizewinner for schizophrenia Gianfilippo Coppola, Ph.D., stem cells reported July 16, 2015 research, Patrick McGorry, M.D., 2013 Young Investigator, in Cell that overproduction of Ph.D., of the University of Melbourne, Australia, along with was also a member of the scientific team. certain cell types during early study leader Dr. G. Paul Amminger and colleagues, reported development could lead to faulty that a 12-week course of omega-3 polyunsaturated fatty acid wiring in the brains of people with (PUFA) supplements reduced the risk that young adults would autism. The study was led by Flora develop schizophrenia or other psychiatric illnesses. M. Vaccarino, M.D., Ph.D., of Yale University and included Gianfilippo Coppola, Ph.D.* A decade ago, the same team conducted the first trial showing that omega-3 PUFAs prevented a first episode of psychotic To follow early brain development in cells with the same disorder for up to one year. On August 11, 2015 they reported genetic makeup as those in people with autism, Dr. results of their new research in Nature Communications. Vaccarino’s team sampled skin cells from four people with the disorder and then reprogrammed them to redevelop as Several controlled trials have shown that supplementation neurons. The scientists watched as the reprogrammed cells with omega-3 PUFAs can reduce psychotic symptoms. Since divided, became more specialized, and organized themselves these have no clinically relevant adverse effects and are into structures called organoids, composed of neurons at a considered beneficial to health, they are ideal candidates for developmental stage equivalent to the first trimester of human prevention of psychosis," the team said. fetal development. The new study looked at the longer-term impact of the The team compared organoids derived from the cells of people supplements, among 81 people aged 13 to 25 with early with autism to a set derived from cells of the patients’ fathers, psychosis. After following the patients for an average of 6.7 who did not have autism. In the patient-derived organoids, years after treatment, 9.8% who received the omega-3 PUFAs they found an overabundance of inhibitory neurons which had at some point developed a psychotic disorder, compared dampen the signals of other cells. Cells in the autism-derived to 40% of those who received placebos. organoids also divided more quickly than those in the organoids derived from the cells of unaffected individuals. The team investigated whether omega-3 PUFA supplementation reduced need for antipsychotic medication. The researchers linked excessive numbers of inhibitory neurons The proportion of individuals who reported having been at least in part to the over activity of a gene called FOXG1. prescribed antipsychotic medication at follow-up was 29.4% When they grew new brain-like organoids from the same (10/34) in the omega-3 PUFA group and 54.3% (19/35) in the autistic individuals but this time artificially decreasing the placebo group. activity of the FOXG1 gene, some of the key developmental defects did not appear. The normal balance of excitatory and It’s not clear exactly how omega-3 PUFAs affect the inhibitory neurons was restored. development of psychosis. It has been postulated to reduce inflammation in the brain and aid the growth of new neurons. The findings suggest that measuring FOXG1 activity could help clinicians more accurately diagnose autism spectrum disorders. They also suggest that targeting FOXG1 may be an effective strategy for developing new drugs to treat autism.

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NEXT-GENERATION DIAGNOSTIC/ BASIC RESEARCH/ Chadi Abdallah, M.D. TREATMENT: DEPRESSION Avshalom Caspi, Ph.D. NEXT-GENERATION DIAGNOSIS: ADHD Yale University Size of Brain Structure May Duke University 2015 Klerman Prize Predict Effectiveness of 2010 Ruane Prizewinner Distinguishing Childhood and Honorable Mention Ketamine Adult Forms of ADHD 2014, 2012 NARSAD Young Investigator Grant Among the symptoms experienced Despite assumptions that adult *Including: by people who develop post- ADHD is a childhood-onset Sanjay Mathew, M.D., traumatic stress disorder (PTSD) neurodevelopmental disorder, no 2009 Independent is “anxious arousal”—feeling long-term study has described Investigator, 2006, 2001 Terrie E. Moffitt, Ph.D. Young Investigator and tense or easily startled much of the childhood period of adults Ramiro Salas, Ph.D., 2012 the time. New research published Duke University diagnosed with ADHD. A team Young Investigator in the April 2015 issue of the 2010 Ruane Prizewinner led by Avshalom Caspi, Ph.D., journal JAMA Psychiatry linked the 2010 Ruane Prize winner, these symptoms to a reduction in performed retrospective analyses the size of the amygdala, a structure deep in the brain that is of people with ADHD diagnosed associated with fear processing and emotion. in adulthood and compared them with analyses of people diagnosed The team, led by Robert H. Pietrzak, Ph.D., of the in childhood. Department of Veterans Affairs National Center for PTSD Guilherme V. Polanczyk, in Connecticut and included Chadi Abdallah, M.D. of M.D., Ph.D. The team, which also included Yale University, wanted to evaluate whether amygdala size Terrie E. Moffitt, Ph.D., correlates with certain clusters of symptoms, rather than the University of São Paulo School co-winner with Dr. Caspi of the of Medicine, Brazil overall disorder. 2010 Ruane Prize, and Guilherme 2008 NARSAD Young Investigator V. Polanczyk, M.D., Ph.D., of the The scientists used magnetic resonance imaging to assess the University of São Paulo School size of the hippocampus and the amygdala in 48 combat of Medicine, Brazil, reported veterans who served in Iraq or Afghanistan, 23 of whom had results in the American Journal of been diagnosed with PTSD. Psychiatry on October 1, 2015.

For each patient, the team correlated the size of the amygdala They found that during childhood, six percent of the group, and hippocampus to the severity of each of five categories mostly boys, was diagnosed with ADHD. But in adulthood, of symptoms: 1) anxious arousal; 2) dysphoric arousal (sleep only three percent received an ADHD diagnosis, with males difficulties), 3) re-experiencing (through dreams, flashbacks, and females affected about equally. The great surprise was or frightening thoughts), 4) avoidance (of reminders of the that almost none of those with adult ADHD were among traumatic event) and 5) emotional numbness. the portion of the group that had been diagnosed during childhood. Ninety percent of adult ADHD cases lacked a There was one significant correlation: in veterans with the history of childhood ADHD. most severe anxious arousal symptoms, the right amygdala was smaller than it was in other study participants. They also If this finding is replicated in other studies, i.e., if a found that the right amygdala was smallest in veterans who childhood ADHD group and a demographically comparable had been exposed to the most severe combat. adult ADHD group are found to comprise virtually non- overlapping sets, then it is possible, the researchers say, that The findings suggest that combat exposure may contribute to adult ADHD is not a neurodevelopmental disorder that shrinking of the amygdala, which is in turn associated with begins in childhood, as is widely believed, but may in fact be increased anxious arousal. a separate condition with other causes.

BRAIN & BEHAVIOR RESEARCH FOUNDATION 15

NEXT-GENERATION TREATMENT: When compared with 181 people with a similar history Nina R. Schooler, Ph.D. PSYCHOSIS, SCHIZOPHRENIA (a single episode of psychosis) who received the usual care offered in community care settings, 223 people who State University of New York Hopeful News on received the NAVIGATE treatment approach: 1) remained Downstate Medical Center Comprehensive Team Treatment in treatment longer; 2) experienced greater improvement Scientific Council Member of Early Psychosis in quality of life, including interpersonal relationships; 3) 1998 NARSAD Distinguished experienced greater relief from overall symptoms as well as Investigator Grant There was hopeful news in 2015 depression; and 4) improved more in involvement in work for people suffering from psychosis. and school. Early intervention and coordinated team care can make a real, positive Two important observations based on two years of clinical difference in outcomes for first- testing of the NAVIGATE approach merit special attention. episode psychosis patients; and One was that earlier implementation of the full, coordinated Kim T. Mueser, Ph.D. there is a way of delivering such treatment approach following a first episode of psychosis care that has been demonstrated correlated directly with better outcome. A second notable Boston University to work effectively in a series of observation: patients who received the full coordinated 2003 NARSAD Distinguished Investigator Grant randomly selected community- treatment needed lower doses of antipsychotic medication, 1989, 1988 NARSAD based mental health clinics located on average, to maintain a good quality of life. Young Investigator Grant in various places across the U.S.

*Including These and other important Mary F. Brunette, M.D., 2000 related results are based on two Young Investigator; Christoph U. Correll, M.D., years of treating patients in the 2007 Young Investigator; NAVIGATE program, which Jennifer D. Gottlieb, Ph.D., was evaluated in the RAISE 2009 Young Investigator; Robert K. Heinssen, Ph.D., Early Treatment Program (ETP), 1990 Young Investigator; organized by the National Institute Delbert G. Robinson, M.D., of Mental Health (NIMH). 2005 Independent Investigator The research team, reporting October 20, 2015 in the American Journal of Psychiatry, was led by John M. Kane, M.D., of Hofstra North Shore-LIJ School of Medicine, and included seven recipients of NARSAD Grants, including Nina R. Schooler, Ph.D. and Kim T. Mueser, Ph.D.

At the heart of the program studied were comprehensive first-episode psychosis intervention that emphasizes low-dose antipsychotic medications, cognitive-behavioral therapy to increase resiliency and illness self-management skills for the patient, family psychoeducation and support and supported employment and education.

2015 Annual Report 2015 INVESTMENTS in NARSAD Research Grants

Many of our grantees go on in their careers to serve in leadership positions in the mental health field.

BRAIN & BEHAVIOR RESEARCH FOUNDATION Since 1987, the Foundation has awarded more than $342 million to fund more than 5,000 grants to more than 4,000 leading scientists around the world.

NARSAD Grants Support The Most Promising Ideas in Brain Research:

• Basic Research to understand what happens in the brain to cause mental illness.

• New Technologies to advance or create new ways of studying or understanding the brain. In 2015 a record number of grant • Next Generation Therapiesto reduce symptoms of mental illness and applications (more than 1,200) ultimately cure and prevent brain and behavior disorders. were submitted to the Foundation for consideration.

NARSAD Distinguished Investigator Grants

• Initiated in 1988.

• Enable outstanding scientists to pursue new, cutting edge ideas with the greatest potential for breakthroughs.

• $100,000 for one year.

• More than $38 million funded.

NARSAD Independent Investigator Grants

• Initiated in 1995.

• Support mid-career scientists during the critical period between initiation of research and receipt of sustained funding.

• Up to $100,000 for two years.

• More than $74 million funded.

NARSAD Young Investigator Grants

• Initiated in 1987.

• Help researchers launch careers in neuroscience and psychiatry and gather pilot data to apply for larger federal and university grants.

• Up to $70,000 for two years. OUR IMPACT: NARSAD Grant recipients have gone on to receive more than • More than $230 million funded. $3 billion in additional research funding in next stage NIMH and NIH grants.

2015 Annual Report Distinguished INVESTIGATORS

181 Applications 15 Grants $1.5M Awarded

The NARSAD Distinguished Investigator Grants provide support for experienced investigators (full professor or equivalent) conducting neurobiological and behavioral research. One-year grants of $100,000 each are provided for established scientists pursuing particularly innovative project ideas.

Distinguished Investigator Grants fund talented, established scientists with a record of outstanding research accomplishments. These research projects might provide new approaches to understanding or treating severe mental illness. If successful, the grants could result in later funding from other sources. These grants are among the most competitive in mental health research and demonstrate the power of investigator-initiated research to bring out new and creative ideas.

BRAIN & BEHAVIOR RESEARCH FOUNDATION “We received a large number of outstanding proposals. Some deal with a specific research problem in one area of mental illness; many are relevant for a number of illnesses; some involve basic research that will serve as the basis of clinical or translational research; and others start from a translational or clinical foundation. We are able to see the growth of the field and the manifestations of the enhanced power of research related to mental illness that have come about with the remarkable support of the Brain & Behavior Research Foundation.”

JACK D. BARCHAS, M.D. Chair, Distinguished Investigator Selection Committee Founding Member of the Foundation’s Scientific Council Chair and Barklie McKee Henry Professor of Psychiatry Weill Cornell Medical College Psychiatrist-in-Chief Weill Cornell Medical Center, NewYork-Presbyterian Hospital and Payne Whitney Clinic

Basic Research MENTAL ILLNESS: GENERAL Next Generation Therapies Bernice Ann Pescosolido, Ph.D. Indiana University ADDICTION DEPRESSION Yavin Shaham, Ph.D. SCHIZOPHRENIA Jeffrey H. Meyer, M.D., Ph.D., FRCP(C) National Institute on Drug Abuse Moses V. Chao, Ph.D. University of Toronto, Canada New York University AUTISM SPECTRUM DISORDER POST-TRAUMATIC STRESS DISORDER Daniel H. Geschwind, M.D., Ph.D. Paul J. Kenny, Ph.D. (PTSD) University of California, Los Angeles Icahn School of Medicine at Ismene L. Petrakis, M.D. Mount Sinai Yale University Nahum Sonenberg, Ph.D. McGill University, Canada Anthony John Koleske, Ph.D. SCHIZOPHRENIA Yale University Edwin S. Levitan, Ph.D. DEPRESSION University of Pittsburgh Michel Barrot, Ph.D. Jonathan S. Mill, Ph.D. Centre National de la Recherche University of Exeter, United Kingdom Scientifique and University of Strasbourg, France David L. Sulzer, Ph.D. Columbia University Catherine G. Dulac, Ph.D. Harvard University

BIPOLAR DISORDER Alan Stewart Brown, M.D., M.P.H. Columbia University

2015 Annual Report Independent INVESTIGATORS

315 Applications 40 Grants $3.9M Awarded

Ground-breaking scientists already proven in their field receive the NARSAD Independent Investigator Grant. These scientists seek to produce experimental results that will put them in a position to initiate major research programs. This support comes at the critical middle period in the investigators’ careers— ROBERT M. POST, M.D., PH.D. the phase between the initiation of research and the receipt of sustained funding. With proven success as highly productive scientists, they seek to make Chair, Independent Investigator clinically relevant advances in the study and treatment of a range of brain and Selection Committee behavior disorders. Foundation Scientific Council Member Head, Bipolar Collaborative Network Independent Investigator Grants provide each scientist with up to $50,000 per Professor of Psychiatry year for two years to support their work during the critical period between the George Washington School of Medicine start of the research and the receipt of sustained funding.

BRAIN & BEHAVIOR RESEARCH FOUNDATION Basic Research Christopher Barnaby Nelson, Ph.D. Next Generation Therapies Orygen Youth Health Research Centre (OYHRC), University of Melbourne, Australia ATTENTION-DEFICIT HYPERACTIVITY AUTISM SPECTRUM DISORDER DISORDER (ADHD) Francesco Papaleo, Ph.D. Suzanne Paradis, Ph.D. Satinder K. Singh, Ph.D. Italian Institute of Technology Brandeis University Yale University Kevin M. Spencer, Ph.D. BIPOLAR DISORDER BIPOLAR DISORDER (BD) VA Boston Healthcare System, Brockton, Jean-Martin Beaulieu, Ph.D. Tomas Hajek, M.D., Ph.D. Harvard University Laval University, Québec Dalhousie University, Nova Scotia Joseph Ventura, Ph.D. Christopher E. Ramsden, M.D. DEPRESSION University of California, Los Angeles National Institute of Neurological Disorders Chadi A. Calarge, M.D. and Stroke Baylor College of Medicine Stanislav S. Zakharenko, M.D., Ph.D. St. Jude Children’s Research Hospital DEPRESSION Ming-Hu Han, Ph.D. Venetia Zachariou, Ph.D. Icahn School of Medicine at Mount Sinai Karen Zito, Ph.D. Icahn School of Medicine at Mount Sinai University of California, Yingxi Lin, Ph.D. Davis Medical Center MULTIPLE DISORDERS Massachusetts Institute of Technology Jay A. Gottfried, M.D., Ph.D. SUICIDE Northwestern University MOOD DISORDERS Daniel Paul Dickstein, M.D. Samer Hattar, Ph.D. Brown University Sachin Patel, M.D., Ph.D. Johns Hopkins University Vanderbilt University TIC DISORDERS Gregg D. Stanwood, Ph.D. Christopher J. Pittenger, M.D., Ph.D. POST-TRAUMATIC STRESS DISORDER Florida State University Yale University (PTSD) Adriana Feder, M.D. POST-TRAUMATIC STRESS DISORDER Icahn School of Medicine at Mount Sinai (PTSD) New Technologies Tanja Jovanovic, Ph.D. Ilan Harpaz-Rotem, Ph.D. Emory University Yale University DEPRESSION Bo Li, Ph.D. Gilles R.C. Pourtois, Ph.D. SCHIZOPHRENIA Cold Spring Harbor Laboratory Ghent University, Belgium Raymond Y. Cho, M.D., M.Sc. University of Texas Health Science Center Rajesh Narendran, M.D. Laura Rachel Stroud, Ph.D. at Houston University of Pittsburgh The Miriam Hospital, Brown University Dean Francis Salisbury, Ph.D. SCHIZOPHRENIA MULTIPLE DISORDERS University of Pittsburgh School of Medicine Alan Anticevic, Ph.D. Adam Kepecs, Ph.D. Yale University Cold Spring Harbor Laboratory

Murray J. Cairns, Ph.D. Kirsty Millar, Ph.D. University of Newcastle, Australia University of Edinburgh, Scotland

Ana Luisa M. Carvalho, Ph.D. Jason James Radley, Ph.D. University of Coimbra, Portugal University of Iowa

Michael Andrew Fox, Ph.D. SCHIZOPHRENIA Virginia Tech Judith Gault, Ph.D. University of Colorado, Denver Wen-Jun Gao, M.D., Ph.D. Drexel University College of Medicine

Jacob M. Hooker, Ph.D. Massachusetts General Hospital, Harvard University

2015 Annual Report Young INVESTIGATORS

712 Applications 191 Grants $13.1M Awarded

NARSAD Young Investigator Grants cover a broad spectrum of mental illnesses and serve as catalysts for additional funding, providing researchers with “proof of concept” for their work. The Foundation awarded a total of HERBERT Y. MELTZER, M.D. $13 million to its 2015 Young Investigators, strengthening its investment in Chair, Young Investigator Grant the most promising ideas to lead advancements in understanding and treating Selection Committee brain and behavior disorders. Founding Member of the Scientific Council Professor of Psychiatry and Behavioral Young Investigator Grants provide each scientist with up to $35,000 per year Sciences and of Physiology for two years totaling $70,000 to enable promising investigators to either Northwestern University, Feinberg School extend research fellowship training or begin careers as independent research of Medicine faculty. Every Young Investigator gets support and guidance from a scientific Dr. Meltzer has reviewed more than mentor designated by the Scientific Council. 14,784 grant applications since 1987.

BRAIN & BEHAVIOR RESEARCH FOUNDATION Basic Research AUTISM SPECTRUM DISORDER Fernando S. Goes, M.D. Brendon M. Nacewicz, M.D., Ph.D. Johns Hopkins University University of Wisconsin-Madison ADDICTION Olivia Engmann, Ph.D. Amit Agarwal, Ph.D. Kimberly Lynn Hills Carpenter, Ph.D. Icahn School of Medicine at Mount Sinai Johns Hopkins University Duke University Medical Center Liisa Hantsoo, Ph.D. Stephan Lammel, Ph.D. Daniel H. Ebert, M.D., Ph.D. University of Pennsylvania University of California, Berkeley Johns Hopkins University School of Medicine Poornima A. Kumar, Ph.D. Jocelyn Margaret Richard, Ph.D. Min Fu, Ph.D. McLean Hospital and Harvard University Johns Hopkins University Duke University Tara Anne LeGates, Ph.D. Benjamin Thomas Saunders, Ph.D. Theofanis Karayannis, Ph.D. University of Maryland School of Medicine Johns Hopkins University New York University Kathryn M. Lenz, Ph.D. Lucas Sjulson, M.D., Ph.D. Miranda M. Lim, M.D., Ph.D. Ohio State University New York University Portland VA Medical Center and Oregon Health and Science University Byungkook Lim, Ph.D. ATTENTION-DEFICIT HYPERACTIVITY University of California, San Diego DISORDER (ADHD) Olga Penagarikano, Ph.D. Lisa Anne Briand, Ph.D. University of the Basque Country, Spain Brittany Leigh Mason, Ph.D. Temple University University of Texas Southwestern Medical Center Susan B. Perlman, Ph.D. at Dallas Joseph Stephen Ralker, Ph.D. University of Pittsburgh Florida International University Bradley Ress Miller, M.D., Ph.D. Tyler K. Perrachione, Ph.D. Columbia University Shona Lee Ray-Griffith, M.D. Boston University University of Arkansas for Medical Sciences Veronica Musante, Ph.D. Caroline Elizabeth Robertson, Ph.D. Yale University Karen E. Seymour, Ph.D. Massachusetts Institute of Technology Johns Hopkins University School of Medicine Sarah Ordaz, Ph.D. Stephan J. Sanders, BMBS, Ph.D. Stanford University Robert Whelan, Ph.D. University of California, San Francisco University College Dublin, Ireland Jodi Lynn Pawluski, Ph.D. Nasim Vasli, Ph.D. University of Rennes, France ANXIETY Centre for Addiction and Mental Health, Jiook Cha Ph.D. University of Toronto, Canada Marta Pecina, M.D., Ph.D. Columbia University University of Michigan BIPOLAR DISORDER Jacek Debiec, M.D., Ph.D. Ezra Wegbreit, Ph.D. Joaquin Piriz, Ph.D. University of Michigan Brown University National Scientific and Technical Research Coun- cil (CONICET), Argentina Edward Korzus, Ph.D. DEPRESSION Neuropsychiatric Institute & Hospital at the Uni- Agustin Anastasia, Ph.D. Peter Rudebeck, Ph.D. versity of California, Los Angeles Weill Cornell Medical College Icahn School of Medicine at Mount Sinai

Sabine Krabbe, Ph.D. David Bulkin, Ph.D. Jonathan B. Savitz, Ph.D. Friedrich Miescher Institute, Switzerland Cornell University Laureate Institute for Brain Research

Ekaterina Likhtik, Ph.D. Ramesh Chandra, Ph.D. Neil Schwartz, Ph.D. Columbia University University of Maryland University of California, San Francisco

Dean Mobbs, Ph.D. Revathy U. Chottekalapanda, Ph.D. Desiree Rosa Maria Seib, Ph.D. Columbia University The Rockefeller University University of British Columbia, Canada

Ilya E. Monosov, Ph.D. Esther M. Berrocoso, Ph.D. Marisa S.P. Toups, M.D. Washington University University of Cadiz, Spain University of Texas Southwestern Medical Center at Dallas George Dragoi, M.D., Ph.D. Yale University

2015 Annual Report MULTIPLE DISORDERS OBSESSIVE COMPULSIVE DISORDER John A. Gray, M.D., Ph.D. Todd Hancock Ahern, Ph.D. Patricia A. Gruner, Ph.D. Davis Medical Center, University of California Quinnipiac University Yale University Stephanie Mary Groman, Ph.D. Samuel Alan Barnes, Ph.D. Joshua L. Plotkin, Ph.D. Yale University University of California State University of New York at Stony Brook Marc Aaron Heiser, M.D., Ph.D. Anna Verena Beyeler Ph.D. POST-TRAUMATIC STRESS DISORDER University of California, Los Angeles Massachusetts Institute of Technology (PTSD) Mark Paul Brandon, Ph.D. Jonathan D. Hommel, Ph.D. Gwendolyn Gabrielle Calhoon, Ph.D. McGill University/Douglas Mental Health University of Texas Medical Branch Massachusetts Institute of Technology University Institute, Canada at Galveston

Daniel Cavanaugh, Ph.D. Nikolaos P. Daskalakis, M.D., Ph.D. Shantanu P. Jadhav, Ph.D. University of Pennsylvania Icahn School of Medicine at Mount Sinai Brandeis University

Catherine Christian, Ph.D. Diasynou Fioravante, Ph.D. Abigail Susan Kalmbach, Ph.D. University of Illinois University of California, Davis Medical Center Columbia University

Joanna Molly Dragich, Ph.D. Talya Greene, Ph.D. Said Kourrich, Ph.D. Columbia University University of Haifa, Israel University of Texas Southwestern Medical Center at Dallas Monica Dus, Ph.D. Dmitri Young, Ph.D. University of Michigan University of California, San Francisco Viviane Labrie, Ph.D. Centre for Addiction and Mental Health, Christina Marie Gremel, Ph.D. Moriel Zelikowsky, Ph.D. University of Toronto, Canada University of California, San Diego California Institute of Technology Hanmi Lee, Ph.D. Michael M. Halassa, M.D., Ph.D. SCHIZOPHRENIA Stanford University New York University Renata Batista-Brito, Ph.D. Yale University Hiroshi Makino, Ph.D. Gretchen L. Hermes, M.D., Ph.D. University of California, San Diego Yale University Estefania Pilar Bello, Ph.D. Columbia University Amanda McCleery, Ph.D. Kathryn Leigh Humphreys, Ph.D. University of California, Los Angeles Tulane University Francois Bourque, M.D. McGill University/Douglas Mental Health Alex S. Nord, Ph.D. Katherine M. Nautiyal, Ph.D. University Institute, Canada University of California, Davis Columbia University Michael Edward Cahill, Ph.D. Gaurav H. Patel, M.D., Ph.D. Ramin Pashale, Ph.D. Icahn School of Medicine at Mount Sinai New York State Psychiatric Institute/ University of Wisconsin-Milwaukee Columbia University Alana May Campbell, Ph.D. Robert Mark Richardson, M.D., Ph.D. University of North Carolina at Chapel Hill Albert R. Powers, M.D. University of Pittsburgh Yale University Francesco Errico, Ph.D. Nicolas W. Simon, Ph.D. Ceinge Biotecnologie Avanzate, Italy Matthew David Puhl, Ph.D. University of Pittsburgh McClean Hospital/Harvard University Ragy R. Girgis, M.D. Nien-Pei Tsai, Ph.D. Columbia University Stephen Ripke, M.D., Ph.D. University of Illinois at Urbana-Champaign Charite—University Medicine Berlin, Jill R. Glausier, Ph.D. Freie Universitat Berlin, Germany Taehong Yang, Ph.D. University of Pittsburgh University of California, San Francisco Antonio Sanz-Clemente, Ph.D. Jacob Gratten, Ph.D. Northwestern University Erika Yeh, Ph.D. University of Queensland, Australia University of California, San Francisco Jeffrey N. Savas, Ph.D. Northwestern University

BRAIN & BEHAVIOR RESEARCH FOUNDATION Shushruth Shushruth, M.B.B.S., Ph.D. MULTIPLE DISORDERS Dylan Grace Gee, Ph.D. Columbia University Renato Pollmanti, Ph.D. Weill Cornell Medical College Yale University Katharine Natasha Thakkar, Ph.D. Catherine Alexandra Hartley, Ph.D. University Medical Center Utrecht, Holland Daniel Schmidt, Ph.D. Weill Cornell Medical College University of Minnesota Marie-Eve Tremblay, Ph.D. Emily Sue Kappenman, Ph.D. Laval University, Quebec, Canada POST-TRAUMATIC STRESS DISORDER University of California, Davis Medical Center (PTSD) Christiaan H. Vinkers, M.D., Ph.D. Tracy A. Butler, M.D. Stephen Eric Nybo, Ph.D. University Medical Center Utrecht, Holland New York University School of Medicine Ferris State University

Gemma Margaret Williams, MBBCh SCHIZOPHRENIA Lauren M. Osborne, M.D. Cardiff University, UK Jose Alejandro Cortes-Briones, Ph.D. Johns Hopkins University Yale University Ki-Jun Yoon, Ph.D. Laura Sagliano, Ph.D. Johns Hopkins University Erik Michael DeBoer, Ph.D. Second University of Naples, Italy University of Pennsylvania OTHER DISORDERS Simona Scaini, Ph.D. EATING DISORDERS Edmund Lalor, Ph.D. San Raffaele Vita-Salute University, Italy Summer Fontaine Acevedo, Ph.D. Trinity College Dublin, Ireland Southwestern Medical Center of the Shari A. Steinman, Ph.D. University of Texas in Dallas Aviv Abraham Mezer, Ph.D. New York State Psychiatric Institute, Columbia Hebrew University, Israel University Elisa S. Na, Ph.D. University of Michigan SUICIDE PREVENTION Richard Michiel van Rijn, Ph.D. Megan Lee Fitzgerald, Ph.D. Purdue University Columbia University NEW TECHNOLOGIES AUTISM SPECTRUM DISORDER OTHER DISORDERS Marta Biagioli, Ph.D. FRAGILE X University of Trento, Italy AUTISM SPECTRUM DISORDER (ASD) Manish Saggar, Ph.D. Kwanghun Chung, Ph.D. Stanford University Julien Christian Roger Dubois, Ph.D. Massachusetts Institute of Technology California Institute of Technology

DEPRESSION NEXT GENERATION BIPOLAR DISORDER Priti Balchandani, Ph.D. THERAPIES Alexis Estelle Whitton, Ph.D. Icahn School of Medicine at Mount Sinai Maclean Hospital/Harvard University

George M. Slavich, Ph.D. ADDICTION University of California, Los Angeles David Louis Pennington, Ph.D. Northern California Institute for Mariano Soiza-Reilly, Ph.D. Research and Education INSERM, France University of California, San Francisco

Amber Leaver, Ph.D. James J. Prisciandaro, Ph.D. University of California, Los Angeles Medical University of South Carolina

ATTENTION-DEFICIT HYPERACTIVITY DISORDER (ADHD) Merideth Alice Addicott, Ph.D. Duke University

Hadi Hosseini, Ph.D. Stanford University

ANXIETY

2015 Annual Report DEPRESSION MULTIPLE DISORDERS SCHIZOPHRENIA Melynda Diane Casement, Ph.D. Satoru Ikezawa, M.D., Ph.D. Anthony Olufemi Ahmed, Ph.D. University of Pittsburgh National Center of Neurology & Psychiatry, Weill Cornell Medical College Japan Evangelia G. Chrysikou, Ph.D. Lisa Anne Buchy, Ph.D. University of Kansas Nicole Rachel Kozloff, M.D. University of Calgary, Canada St. Michael’s Hospital and the University of Laura K. Fonken, Ph.D. Toronto, Canada Sasja Noriko Duijff, Ph.D. University of Colorado University Medical Center of Utrecht, Holland Timothy Y. Mariano, M.D., Ph.D., M.Sc. Brian M. Iacoviello, Ph.D Brown University Anne-Kathrin J. Fett, Ph.D. Icahn School of Medicine at Mount Sinai Vrije Universiteit, Holland Andrada Delia Neacsiu, Ph.D. Dawn F. Ionescu, M.D. Duke University Medical Center Daniel John Foster, Ph.D. Massachusetts General Hospital and Vanderbilt University Medical Center Harvard University Ueli Rutishauser, Ph.D. Cedars-Sinai Medical Center at the University David Gyllenberg, M.D., Ph.D. Clare Kelly, Ph.D. of California Los Angeles University of Turku, Finland Trinity College Dublin, Ireland Antonios S. Zannas, M.D., Carol Jahshan, Ph.D. Donel M. Martin, Ph.D. Max-Planck Institute for Psychiatry, Germany University of California, Los Angeles University of New South Wales, Australia OBSESSIVE-COMPULSIVE DISORDER Heeyoung Lee, Ph.D. Mark J. Niciu, M.D., Ph.D. George McConnell, Ph.D. University of Pittsburgh National Institute of Mental Health Duke University Shupeng Li, M.D., Ph.D. Darren Michael Opland, Ph.D. POST-TRAUMATIC STRESS DISORDER Centre for Addiction and Mental Health, Yale University (PTSD) University of Toronto, Canada Lynnette Astrid Averill, Ph.D. Leah H. Somerville, Ph.D. Yale University Rachel L. C. Mitchell, Ph.D. Harvard University King’s College London, UK Isaac Galatzer-Levy, Ph.D. Marie Spies, M.D. New York University School of Medicine Nigel Craig Rogasch, Ph.D. University of Vienna, Austria Monash University, Australia Jamie Lynn Peters, Ph.D. Oren Tene, M.D. Medical University of South Carolina Jerri M. Rook, Ph.D. Tel Aviv University, Israel Vanderbilt University Medical Center Basant K. Pradhan, M.D. Erin Christine Tully, Ph.D. Cooper University Hospital & Cooper Medical Douglas Ruderfer, Ph.D. Georgia State University School of Rowan University Icahn School of Medicine at Mount Sinai

Ryan Van Lieshout, M.D., Ph.D. SUICIDE PREVENTION OTHER DISORDERS McMaster University, Canada Emily B. Ansell, Ph.D. ANOREXIA Yale University Sahib Khalsa, M.D., Ph.D. Christian Anthony Webb, Ph.D. University of Tulsa Maclean Hospital/Harvard University Haggai Sharon, M.D. Tel Aviv University, Israel Pei-an (Betty) Shih, Ph.D. University of California

BORDERLINE PERSONALITY DISORDER Vanessa Nieratschker, Ph.D. University of Tübingen, Germany

BRAIN & BEHAVIOR RESEARCH FOUNDATION Meet the Scientist Our cutting edge educational A Free Monthly Q&A Webinar Series programs are a resource to hundreds Join By Phone or On The Web Tuesdays at 2:00pm est of individuals each year.

2016

JULY 12 Life Elevated: Examining Altitude-Related Effects on Mental Illness Perry F. Renshaw, M.D., Ph.D. University of Utah School of Medicine

AUGUST 9 Autism: Understanding the Causes and Developing Effective Treatments Jacqueline N. Crawley, Ph.D. University of California, Davis School of Medicine, Sacramento

SEPTEMBER 13 Living Well with ADHD: Scientific Guideposts to Improved Outcomes Francisco Xavier Castellanos, M.D. New York University Child Study Center

OCTOBER 18 A Beautiful Mind: John Nash, Schizophrenia, Game Theory and Recovery from Schizophrenia With and Without Medication Herbert Y. Meltzer, M.D. Northwestern University Feinberg School of Medicine

NOVEMBER 8 Could We Someday Prevent Schizophrenia Like We Prevent Cleft Palate? Robert R. Freedman, M.D. University of Colorado School of Medicine

DECEMBER 13 Neuroinflammatory Hypotheses of Depression Yvette I. Sheline, M.D. University of Pennsylvania

MODERATOR Jeffrey Borenstein, M.D. President & CEO, Brain & Behavior Research Foundation Host of the Public Television Series Healthy Minds

2015 Annual Report OUR SCIENTIFIC COUNCIL 165 MEMBERS

2 Nobel Prize Winners

4 Former Directors of the National Institute of Mental Health

4 Recipients of the National Medal of Science

13 Members of the National Academy of Sciences

21 Chairs of Psychiatry & Neuroscience Departments at Leading Medical Institutions

47 Members of the Institute of Medicine

BRAIN & BEHAVIOR RESEARCH FOUNDATION President Herbert Pardes, M.D.

Vice President Emeritus Floyd E. Bloom, M.D.

Anissa Abi-Dargham, M.D. Jay A. Gingrich, M.D., Ph.D. James H. Meador-Woodruff, M.D. George K. Aghajanian, M.D. David Goldman, M.D. Herbert Y. Meltzer, M.D. Schahram Akbarian, M.D., Ph.D. Frederick K. Goodwin, M.D. Richard J. Miller, Ph.D. Huda Akil, Ph.D. Joshua A. Gordon, M.D., Ph.D. Karoly Mirnics, M.D., Ph.D. Susan G. Amara, Ph.D. Elizabeth Gould, Ph.D. Bita Moghaddam, Ph.D. Stewart A. Anderson, M.D. Anthony A. Grace, Ph.D. Dennis L. Murphy, M.D. Nancy C. Andreasen, M.D., Ph.D. Paul Greengard, Ph.D. Charles B. Nemeroff, M.D., Ph.D. Amy F.T. Arnsten, Ph.D. Suzanne N. Haber, Ph.D. Eric J. Nestler, M.D., Ph.D. Gary S. Aston-Jones, Ph.D. Philip D. Harvey, Ph.D. Andrew A. Nierenberg, M.D. Jay M. Baraban, M.D., Ph.D. Stephan Heckers, M.D. Patricio O’Donnell, M.D., Ph.D. Jack D. Barchas, M.D. Nathaniel Heintz, Ph.D. Steven M. Paul, M.D. Samuel H. Barondes, M.D. René Hen, Ph.D. Godfrey D. Pearlson, MBBS, M.D. Francine M. Benes, M.D., Ph.D. Fritz A. Henn, M.D., Ph.D. Daniel S. Pine, M.D. Karen F. Berman, M.D. Robert M.A. Hirschfeld, M.D. Robert M. Post, M.D. Wade H. Berrettini, M.D., Ph.D. L. Elliot Hong, M.D. James B. Potash, M.D., M.P.H. Randy D. Blakely, Ph.D. Steven E. Hyman, M.D. Steven G. Potkin, M.D. Pierre Blier, M.D., Ph.D. Robert B. Innis, M.D., Ph.D. Pasko Rakic, M.D., Ph.D. Robert W. Buchanan, M.D. Jonathan A. Javitch, M.D., Ph.D. Judith L. Rapoport, M.D. Peter F. Buckley, M.D. Daniel C. Javitt, M.D., Ph.D. Perry F. Renshaw, M.D., Ph.D., M.B.A. William E. Bunney, Jr., M.D. Lewis L. Judd, M.D. Kerry J. Ressler, M.D., Ph.D. Joseph D. Buxbaum, Ph.D. Peter W. Kalivas, Ph.D. Carolyn B. Robinowitz, M.D. William Byerley, M.D. Eric R. Kandel, M.D. Bryan L. Roth, M.D., Ph.D. Marc G. Caron, Ph.D. Richard S.E. Keefe, Ph.D. John L.R. Rubenstein, M.D., Ph.D. William T. Carpenter, Jr., M.D. Samuel J. Keith, M.D. Bernardo Sabatini, M.D., Ph.D. Cameron S. Carter, M.D. Martin B. Keller, M.D. Akira Sawa, M.D., Ph.D. BJ Casey, Ph.D. John R. Kelsoe, M.D. Alan F. Schatzberg, M.D. Dennis S. Charney, M.D. Kenneth S. Kendler, M.D. Nina R. Schooler, Ph.D. Bruce M. Cohen, M.D., Ph.D. James L. Kennedy, M.D. Robert Schwarcz, Ph.D. Jonathan D. Cohen, M.D., Ph.D. Robert M. Kessler, M.D. Philip Seeman, M.D., Ph.D. Peter Jeffrey Conn, Ph.D. Kenneth K. Kidd, Ph.D. Yvette I. Sheline, M.D. Richard Coppola, D.Sc. Mary-Claire King, Ph.D. Pamela Sklar, M.D., Ph.D. Joseph T. Coyle, M.D. Rachel G. Klein, Ph.D. Solomon H. Snyder, M.D., D.Sc., D.Phil. Jacqueline N. Crawley, Ph.D. John H. Krystal, M.D. (Hon. Causa) John G. Csernansky, M.D. James F. Leckman, M.D. Murray Stein, M.D., M.P.H. Karl Deisseroth, M.D., Ph.D. Francis S. Lee, M.D., Ph.D. John S. Strauss, M.D. J. Raymond DePaulo, Jr., M.D. Ellen Leibenluft, M.D. J. David Sweatt, Ph.D. Ariel Y. Deutch, Ph.D. Robert H. Lenox, M.D. John A. Talbott, M.D. Wayne C. Drevets, M.D. Pat Levitt, Ph.D. Carol A. Tamminga, M.D. Ronald S. Duman, Ph.D. David A. Lewis, M.D. Laurence H. Tecott, M.D., Ph.D. Jan A. Fawcett, M.D. Jeffrey A. Lieberman, M.D. Ming T. Tsuang, M.D., Ph.D., D.Sc. Stan B. Floresco, Ph.D. Irwin Lucki, Ph.D. Leslie G. Ungerleider, Ph.D. Judith M. Ford, Ph.D. Robert C. Malenka, M.D., Ph.D. Rita J. Valentino, Ph.D. Alan Frazer, Ph.D. Anil K. Malhotra, M.D. Jim van Os, M.D., Ph.D., MRCPsych Robert R. Freedman, M.D. Husseini K. Manji, M.D., FRCPC Nora D. Volkow, M.D. Fred H. Gage, Ph.D. J. John Mann, M.D. Mark von Zastrow, M.D., Ph.D. Aurelio Galli, Ph.D. John S. March, M.D., M.P.H. Karen Dineen Wagner, M.D., Ph.D. Mark S. George, M.D. Helen S. Mayberg, M.D. Daniel R. Weinberger, M.D. Elliot S. Gershon, M.D. Robert W. McCarley, M.D. Myrna M. Weissman, Ph.D. Mark A. Geyer, Ph.D. Bruce S. McEwen, Ph.D. Jon-Kar Zubieta, M.D., Ph.D. Jay N. Giedd, M.D. Ronald D.G. McKay, Ph.D.

2015 Annual Report OUR NEW SCIENTIFIC COUNCIL Members

Led by Dr. Herbert Pardes, the founding President of our Scientific Council, the all-volunteer group of preeminent mental health researchers review more than 1,000 NARSAD Grant applications each year and select the most promising research ideas with the greatest potential to lead to breakthroughs.

The Foundation’s Scientific Council is composed of 165 world renowned scientists representing every major discipline in brain and behavior research including two Nobel Prize winners, four former directors of the National Institute of Mental Health, four recipients of the National Medal of Science, 13 members of the National Academy of Sciences, 21 Chairs of Psychiatry and Neuroscience Departments at leading medical institutions, and 47 members of the National Institute of Medicine.

The Scientific Council guides the Foundation to fund creative and impactful research relevant to the whole spectrum of mental health.

We welcome our newest members.

BRAIN & BEHAVIOR RESEARCH FOUNDATION TED ABEL, PH.D. is the Brush Family DEANNA M. BARCH, PH.D. is the Gregory EDWIN H. COOK, JR., M.D. is interested Professor of Biology in the School of B. Couch Professor of Psychiatry in the genetics of autism, attention- Arts and Sciences at the University and the Chair of the Department of deficit hyperactivity disorder, of Pennsylvania. Dr. Abel is also Psychological & Brain Sciences at obsessive-compulsive disorder, and Co-Director of the Biological Basis of Washington University in Saint Louis, the development of improved Behavior Program and he directs an MO. She was the Editor of Cognitive, pharmacologic treatments of these NIMH-funded pre-doctoral training Affective and Behavioral Neuroscience, is disorders. As Director of The Laboratory program in behavioral and cognitive currently Deputy Editor at Biological of Developmental Neuroscience and neuroscience. His laboratory’s primary Psychiatry and is on the Editorial Boards Professor, Department of Psychiatry at focus is on understanding the molecular of Schizophrenia Bulletin, Current The Conte Center for Computational and cellular basis of learning and Directions in Psychological Science, Journal Neuropsychiatric Genomics based memory as well as the role of sleep of Abnormal Psychology, and Clinical at The University of Chicago, Dr. Cook in memory storage. Using mouse Psychological Science. Dr. Barch is and his team are dedicated to studying models, Dr. Abel seeks to identify immediate past President of the Society the developmental neurobiological basis novel therapeutic approaches to treat for Research in Psychopathology, is on of pediatric-onset neuropsychiatric cognitive deficits associated with many the DSM-V Revision Committee, is on disorders. psychiatric and neurodevelopmental the Steering Committee for the NIMH They use neurochemical and molecular disorders. Dr. Abel has been a leader Research Domain Criteria initiative, and genetic research tools to develop in applying molecular and genetic is a member of the NIMH Scientific new knowledge that may lead to approaches to define how neural circuits Council. Her research is focused on improvement in clinical pharmacology. mediate behavior, making creative use of understanding the interplay among They began as a neurochemistry lab genetically modified mouse lines to study cognition, emotion, and brain function studying the relationship between the biological basis of behavior. He has to better understand the deficits in hyperserotonemia and autistic published widely in journals that include behavior and cognition found in illnesses disorder. The team is now working Nature, Neuron, Journal of Clinical such as schizophrenia and depression. with collaborators on molecular genetic Investigation and Journal of Neuroscience. She uses functional MRI, structural and clinical pharmacological studies of He is a Fellow of the American College MRI, and cognitive neuroscience autism, attention-deficit hyperactivity of Neuropsychopharmacology, Editor- methods to examine neural basis of disorder, childhood-onset obsessive- in-Chief of Neurobiology of Learning disturbances in cognitive control and compulsive disorder, stuttering, and Memory, and an Associate Editor of emotional processing in individuals with adolescent depression, and pediatric and Behavioral Neuroscience. schizophrenia and those at risk for the early onset bipolar mood disorder. development of schizophrenia, as well as in individuals with mood disorders.

1995 & 2000 Young Investigator 2006 Independent Investigator 2013 Distinguished Investigator

2015 Annual Report RAQUEL E. GUR, M.D., PH.D. is Professor TAKAO K. HENSCH, PH.D. is a joint AMANDA J. LAW, PH.D. is a Professor of Psychiatry, Neurology and Radiology professor of Neurology at Harvard in the Departments of Psychiatry at the University of Pennsylvania’s Medical School at Boston Children’s and Cell and Developmental Biology, Perelman School of Medicine where she Hospital, and Professor of Molecular the Dr. Nancy L. Gary Chair in directs the Neuropsychiatry Section and and Cellular Biology at Harvard’s Children’s Mental Disorders Research the Schizophrenia Research Center and Center for Brain Science. Dr. Hensch’s and Director, Neurodevelopmental is Vice Chair of Research Development research focuses on critical periods in and Neuropsychiatric Genetics Lab in the Department of Psychiatry. Her brain development. By applying cellular at the University of Colorado, School combined training in Neurology and and molecular biology techniques to of Medicine. The primary goal of Psychiatry has provided the tools to neural systems, his lab identified pivotal Dr. Law’s research is to identify and pursue an academic career working inhibitory circuits that orchestrate understand the role of genetic factors with basic and clinical neuroscientists structural and functional rewiring in psychiatric, neurodevelopmental to advance the understanding of of connections in response to early and behavioral disorders. Her research schizophrenia. In directing these sensory experience. His work affects focuses on understanding the molecular, research endeavors, she has interacted not only the basic understanding of cellular and biochemical mechanisms with scientists of diverse backgrounds, brain development, but also therapeutic underlying genetic susceptibility to conducted collaborative interdisciplinary approaches to devastating cognitive severe neurodevelopmental disorders, research, mentored junior faculty and disorders later in life. He currently including schizophrenia; with a view trainees, and has come to know many directs the NIMH Silvio O. Conte to identifying affected neurobiological patients and their families. She is a Center for Basic Mental Health processes and cellular pathways for member and has served in organizations Research at Harvard. He serves on the development of next generation including the Institute of Medicine of the editorial board of various journals, treatments. Dr. Law has focused the National Academy of Sciences, the including Journal of Neuroscience, her research on a multidisciplinary, NIMH Council and the American Journal of Neurodevelopmental Disorders, translational neuroscience approach Psychiatric Association task forces Neural Development, Neuroscience to understanding neurocognitive including the DSM-5 Psychosis work Research, Frontiers in Neural Circuits and neurodevelopmental disorders, group. She is Past President of the and Neuron. combining studies of human Society of Biological Psychiatry and postmortem brain tissue, human President of the American College of peripheral cell systems, primary cell Neuropsychopharmacology. NIMH culture models and transgenic animal has supported her research efforts and models with neuropharmacology and she has over 440 publications in peer- clinical genetics. reviewed journals. 2006 Young Investigator 1999 Distinguished Investigator 2011 Sidney R. Baer, Jr. Prize 2009 Lieber Prize

BRAIN & BEHAVIOR RESEARCH FOUNDATION GARY LYNCH, PH.D. is a Professor, KATHLEEN R. MERIKANGAS, PH.D. is DOST ÖNGÜR, M.D., PH.D. is a native of Psychiatry & Human Behavior and a a Senior Investigator and Chief of Istanbul, Turkey, Dr. Öngür is currently Professor, Anatomy & Neurobiology the Genetic Epidemiology Research Associate Professor of Psychiatry at at the School of Medicine at the Branch in the Intramural Research Harvard Medical School and Chief University of California, Irvine. Dr. Program at the National Institute of the Psychotic Disorders Division Lynch is one of the most cited authors of Mental Health. The major areas at McLean Hospital. His research is in neuroscience, holds 25 patents, of her research are: studies of the funded by the NIMH and focuses on and co-founded two publicly traded patterns and components of familial MRI studies of brain abnormalities in companies. Dr. Lynch’s work led the aggregation of mental disorders and individuals with schizophrenia, bipolar way to the modern theory of how familial mechanisms for comorbidity disorder, and related conditions as synapses encode memory. This involves of mental and medical disorders; well as on the cardiovascular health of a change in the shape, and thus potency, identification of early signs and these patients. In recent years he has of connections that is stabilized by risk factors for psychiatric disorders had a special focus on abnormal brain a reorganization of the subsynaptic among high and low risk youth using bioenergetics and white matter integrity cytoskeleton. He is also the co-inventor prospective longitudinal high risk as pathophysiologic factors in these of ampakines, a class of drugs that studies; and large-scale population- common and severe conditions. In enhance memory and stimulate the based studies of mental disorders addition to his clinical responsibilities production of growth factors. He including high risk designs and and research, Dr. Öngür has received is currently using ampakines in an prospective longitudinal research. awards for his teaching and mentorship attempt to reverse the negative effect of The major project underway in her and holds a K24 award from the NIMH. aging on the anatomy and physiology of research group is a community-based brain cells. family study of affective spectrum 2004 Young Investigator disorders and their overlap with other 2013 Independent Investigator mental disorders, especially anxiety disorders, and medical disorders such as migraine and cardiovascular disease. The goal of this research is to identify the endophenotypes that are closer to the biologic expression of genes underlying these disorders and environmental moderators of genetic expression. Findings from this research are likely to have important implications for targets of prevention and treatment of affective illness.

2015 Annual Report MARINA R. PICCIOTTO, PH.D. is the GERARD SANACORA, M.D., PH.D. MATTHEW W. STATE, M.D., PH.D. Charles B. G. Murphy Professor of is currently a Professor of Psychiatry is the Oberndorf Family Distinguished Psychiatry and Professor in the Child at Yale University and the Director of Professor and Chair of the Department Study Center, of Neuroscience and the Yale Depression Research Program. of Psychiatry at the University of of Pharmacology; Deputy Chair for His work has concentrated largely on California, San Francisco School Basic Science Research, Department elucidating the pathophysiological of Medicine. Dr. State is a child of Psychiatry at Yale University. Her mechanisms associated with mood and psychiatrist and human geneticist research focuses on defining molecular other neuropsychiatric disorders, and studying pediatric neuropsychiatric mechanisms underlying behaviors using this information to guide future syndromes. His lab focuses on gene related to psychiatric illness, with a treatment development. His basic discovery as a launching point for focus on the function of nicotinic science laboratory explores the effects efforts to illuminate the biology acetylcholine receptors in the brain. of chronic stress on brain function, and of these conditions and to develop Her laboratory uses molecular genetic examines the molecular, cellular and novel and more effective therapies. strategies to identify the role of behavioral effects of newly developed He co-leads several international individual molecules in behaviors treatment strategies. His clinical genomics collaborations, including related to depression, addiction, laboratory employs novel imaging the NIH-funded Autism Sequencing cognitive function and food intake. Dr. methodologies to investigate the Consortium and has been the recipient Picciotto is Treasurer of the Society for pathophysiology of neuropsychiatric of multiple awards, including recent Neuroscience, Interim Editor in Chief of disorders and is very active in clinical induction into the Institute of the Journal of Neuroscience, and serves as trial research. Dr. Sanacora has received Medicine and The AACAP George handling editor on the editorial board of the Anna-Monika Stiftung International Tarjan Award for Contributions in several journals. She is a fellow of AAAS Award for the investigation of the Developmental Disabilities. and a member of the National Academy biological substrate and functional of Medicine. disturbances of depression in 2009 2012 Ruane Prize and the Joel Elkes Research Award 1996 Young Investigator for Outstanding contributions to 2004 Independent Investigator Psychopharmacology from the American College of Neuropsychopharmacology in 2011.

1999 & 2001 Young Investigator 2007 Independent Investigator 2014 Distinguished Investigator 2003 & 2005 Klerman Honorable Mention

BRAIN & BEHAVIOR RESEARCH FOUNDATION SUSAN M. VOGLMAIER, M.D., PH.D is an JARED W. YOUNG, PH.D. is an Assistant L. TREVOR YOUNG, M.D., PH.D. is the Associate Professor in the Psychiatry Professor of Psychiatry at the University Dean, Faculty of Medicine and Vice Department at the University of of California San Diego. He is also Provost, Relations with Health Care California, San Francisco School affiliated with the Stein Institute for Institutions Centre for Addiction and of Medicine. Dr. Voglmaier’s lab Research on Aging at UCSD. Dr. Mental Health at the University of has developed precise optical tools Young’s primary interest is understanding Toronto. He is a clinician-scientist who to investigate the mechanisms causes of cognitive and behavioral studies the molecular basis of bipolar that control neurotransmitter dysfunction in serious mental illness with disorder and its treatment. In his lab release over the course of synapse relevance to real world functioning. He Dr. Young is focused on the processes development. The long-term goal developed and uses several cognitive and that lead to long-term changes in brain of this line of research is to target behavioral tests that can be conducted in structure and function in patients specific differences in the membrane rodents and humans so that mechanisms with bipolar disorder, and how mood- trafficking of synaptic vesicle proteins underlying deficient behaviors in humans stabilizing drugs can alter those changes. to normalize the balance of excitatory can be disentangled using rodent studies. He has supervised more than 30 and inhibitory inputs in autism; and His primary interests include developing research and clinical trainees. Dr. Young of subcortical pathways that carry methodologies to assess putative cognitive has received many awards including the sensory information that is compared therapeutics for schizophrenia patients, Douglas Utting Award for outstanding with information about meaning, but he also collaborates with groups contributions in the field of mood conveyed by cortical pathways, in modeling behavior in bipolar disorder disorders, and the Canadian College schizophrenia circuits. patients, as well as identifying genetic of Neuropsychopharmacology Heinz contributions to successful aging. Using Lehmann Award. He is a Distinguished 2007 Young Investigator these paradigms in both humans and Fellow of the American Psychiatric animals provides the opportunity for Association and he has led several bench-to-bedside translational research, large clinical programs including the increasing the likelihood of clinical Mood Disorders Program at Hamilton success for treating the numerous Psychiatric Hospital, which received behavioral and cognitive abnormalities the American Psychiatric Services Gold seen in psychiatric disorders. Achievement Award.

2008 & 2012 Young Investigator 1989 Young Investigator 1995 Independent Investigator 2015 Colvin Prize

2015 Annual Report 2015 FOUNDATION EVENTS

BRAIN & BEHAVIOR RESEARCH FOUNDATION Our Resilient Brain: Coping with Stress, Anxiety & Memory Loss January 23, 2015 Dr. Kafui Dzirasa led a lively discussion about how stress and anxiety affect memory and how to best manage them in everyday life. Following his talk was an opportunity for questions and answers.

Drs. Kafui and Erikka Dzirasa, Sandy and Jill Sirulnick, Dr. Jeff Borenstein John and board member Suzanne Golden Board member Bob and Fran Weisman

Discovery to Recovery: A Path to Healthy Minds Mental Health Conference LOS ANGELES March 10, 2015 This conference was designed to educate caregivers, family members, and people living with mental illness about the most innovative ideas, research and breakthroughs in neuroscience and psychiatry to better understand the causes and develop new ways to effectively treat brain and behavior disorders. A keynote address on living with bipolar disorder was given by Keith O’Neil, Former NFL Player & Super Bowl Champion.

Roberta Gundersen and Shelley Miller, Dr. Fabio Macciardi Dr. Lisa Monteggia co-chairs the L.A. Committee

2015 Annual Report Women Breaking the Silence About Mental Illness NEW YORK June 15, 2015 The women’s luncheon featured a conversation between Hearst Magazine’s Editorial Director Ellen Levine and advocate, and author Lee Woodruff about depression, anxiety and the importance of removing the stigma from mental illness. The luncheon attracted more than 300 people and was held at the Metropolitan Club. More than $150,000 was raised for brain and behavior research.

Above: Back Row: Haley Barrows, Carole Mallement (Committee Co-Chair), Ellen Levine and Lee Woodruff Renee Steinberg and Dr. Jeff Borenstein Harvey Mallement, Margaret Flanagan, Ellen Levine, Dr. Richard Levine, Melinda Fager Front Row: John Golden, Suzanne Golden (Committee Co-Chair), Caroline Hirsch, Lee Woodruff

Klerman & Freedman Awards NEW YORK July 24, 2015

This evening honored the hallmark program of the Brain & Behavior Research Foundation—the NARSAD Young Investigator Grant program—that enables aspiring young scientists with innovative ideas to garner pilot data and generate “proof of concept” for their work. The Annual Klerman & Freedman Prizes recognize exceptional clinical and basic research conducted by NARSAD Young Investigator Grantees.

Six Young Investigator Grantees were honored for their outstanding contributions to mental health research at Le Parker Meridian Hotel. These researchers were chosen by a committee of the Foundation’s Scientific Council for their exceptional NARSAD Grant projects in terms of insight and potential new approaches to the treatment of mental illness. Each investigator has demonstrated exceptional promise in the pursuit of deeper understanding of the human brain to ultimately result in cures through research.

BRAIN & BEHAVIOR RESEARCH FOUNDATION Klerman & Freedman Awards NEW YORK July 24, 2015

Dr. Herbert Pardes and Dr. Alan Anticevic Dr. Carrie McAdams Dr. Michael Halassa Above: Dr. Kristen Brennand Below: Dr. Nandakumar Narayanan

Klerman Prizewinner Honorable Mentions Freedman Prizewinner Honorable Mentions

Alan Anticevic, Ph.D., Chadi G. Abdallah, M.D., Michael M. Halassa, M.D., Ph.D., Kristen J. Brennand, Ph.D., of Yale University for of Yale University, for his of New York University, for of the Icahn School of Med- his 2012 Grant Research 2012 Grant Research Project: his 2012 Grant Research icine at Mount Sinai, for her Project: Working Memory Examining Glutamate/ Project: Systematic Optogenetic 2012 Grant Research Project: Dysfunction in Schizophrenia Glutamine Cycling in the Dissection of the Link Between Modeling Schizophrenia and in a Ketamine Model Frontal Brain of Spindle Expression and Using Human Induced of Psychosis: Translating Depressed Patients During Schizophrenia Etiology Pluripotent Stem Cells: Assess- Computational Modeling to Ketamine Infusion ing the Contribution of Glu- Neuroimaging tamatergic and Dopaminergic Carrie J. McAdams, M.D., Ph.D., Neurons to Disease of the University of Texas Southwestern Medical Nandakumar Narayanan, M.D., Center at Dallas, for her 2012 Ph.D., of the University of Grant Research Project: Iowa, for his 2012 Grant Neurodevelopment of Identity Research Project: in Adolescent Anorexia Nervosa Prefrontal Dopamine and Temporal Control

2015 Annual Report New York Mental Health Research Symposium October 23, 2015 The 27th Annual New York Mental Health Research Symposium featured presentations by the nine 2015 Outstanding Achievement Prizewinners and two exceptionally promising Young Investigator Grantees and was held at The Kaufman Music Center.

Presentations Included

Rethinking Schizophrenia—from the Beginning Fetal Origins of Mental Illness and Wellness Clinical Staging and Personalized Mental Health Care Robert R. Freedman, M.D. Camille Hoffman, M.D., MSCS Patrick McGorry, M.D., Ph.D., FRCP, FRANCZP

Prediction and Prevention of Psychosis in Clinical High Pathways to The Development of Novel Therapies Gloria Neidorf Memorial Lecture: Looking Inside the Cell Risk Young People for Psychiatric Disorders to Understand Bipolar Disorder and its Treatment Barnaby Nelson, Ph.D., MPsych Michael Berk, Ph.D., MBBCh, MMed, FF(Psych)SA, FRANCZP L. Trevor Young, M.D., Ph.D., FRCPC

Treating the Developing Versus Developed Brain Deconstructing the Neurobiology of ADHD Via Open Exploring the Higher Brain Circuits Altered in BJ Casey, Ph.D. Neuroscience Approaches Schizophrenia: Hope for Future Treatments Francisco Xavier Castellanos, M.D. Amy F.T. Arnsten, Ph.D.

Personalized Medicine in The Genomic Era: Treating New Technologies to Monitor How Brain Cells Symposium Moderator Schizophrenia with Precision Communicate—and Sometimes Miscommunicate Robert M.A. Hirschfeld, M.D. Jianping Zhang, M.D., Ph.D. Markita Patricia Landry, Ph.D.

BRAIN & BEHAVIOR RESEARCH FOUNDATION The Outstanding Achievement Awards The Pardes Humanitarian Prize in Mental Health NEW YORK This international Prize recognizes a physician, scientist or public citizen whose extraordinary contribution has made October 23, 2015 a profound and lasting impact by improving the lives of The Foundation celebrated its 28th Annual Awards Dinner people suffering from mental illness and by advancing the at The Pierre Hotel in New York City. The evening’s understanding of mental health. honorees included two remarkable humanitarians, one of the world’s most prominent mental health advocates and Honorees nine exceptional scientists for their significant contributions Beatrix A. Hamburg, M.D. and David A. Hamburg, M.D. to the advancement of our understanding of schizophrenia, mood disorders, child and adolescent psychiatry and Honorary Prize cognitive neuroscience. Rosalynn Carter, former First Lady of the United States Lieber Prize for Schizophrenia Research Robert Freedman, M.D. Patrick McGorry, M.D., Ph.D., FRCP, FRANCZP

Colvin Prize for Mood Disorders Research Michael Berk, Ph.D., MBBCh, MMed, FF(Psych)SA, FRANCZP L. Trevor Young, M.D., Ph.D., FRCPC

Ruane Prize for Child & Adolescent Psychiatric Research BJ Casey, Ph.D. Francisco Xavier Castellanos, M.D.

Goldman-Rakic Prize for Cognitive Neuroscience Amy F. T. Arnsten, Ph.D.

Sidney R. Baer, Jr. Prize for Innovative & Promising Schizophrenia Research Pardes Humanitarian Prize Drs. David A. Hamburg and Herbert Pardes M. Camille Hoffman, M.D., MSCS Barnaby Nelson, Ph.D.

Dr. Barnaby Nelson, Merilyn Ann Hawke and Dr. Patrick McGorry and Drs. BJ Casey and Jeff Borenstein Dr. Amy F. T. Arnsten Drs. Michael and Lesley Berk

2015 Annual Report PARENTING

For the families of young people diagnosed with psychiatric disorders, it can be frightening, bewildering, and frustrating. The Brain & Behavior Research Foundation strives to provide helpful information and insights to those parents and family members who may be caring for children with mental illnesses. Beginning in 2015, the Foundation included in its Quarterly publication information that can be of practical use to families coping with the diagnosis of a behavioral disorder or mental illness.

BRAIN & BEHAVIOR RESEARCH FOUNDATION Childhood Mental Illness

JUDITH L. RAPOPORT, M.D. Chief, Child Psychiatry Branch National Institute of Mental Health Foundation Scientific Council Member

“Children have all sorts of experiences that can worry a parent,” said Judith L. Rapoport, M.D., a Foundation Scientific Council Member and Chief of the NIMH Child Psychiatry Branch. “[But] there’s an important rule of thumb: there is no ‘disorder’ until a problem begins to significantly interfere with a child’s quality of life. When fear or sadness or an inability to concentrate takes over and starts to interfere with the child’s life, either at home or at school, that’s when you should take action.”

Dr. Rapoport said parents can turn to local psychiatrists, psychologists, psychiatric social workers and family physicians if they think their child has a mental illness, which could include attention-deficit hyperactivity disorder (ADHD), anxiety, depression, or schizophrenia, among other conditions. She noted that there are a growing number of behavioral and pharmaceutical treatments that should be tailored to each child. “However, parents should know that they are not locked in to any one approach,” Dr. Rapoport added. “If a few months after you begin a therapy it doesn’t seem that you are getting anywhere you should reconsider and be open to trying a different approach.”

Dr. Rapoport also sought to reassure parents on some of the more common fears about childhood mental illness, such as the possibility of addiction to ADHD medication, or the likelihood of developing childhood-onset schizophrenia. Studies show that the ADHD medicine Ritalin, for example, is not addictive in children with ADHD and does not lead to a tendency to abuse drugs later in life, she said. Similarly, she noted that childhood-onset schizophrenia and bipolar disorder are extremely rare.

Rapoport acknowledged that a child’s mental illness can affect the family as a whole. “Following a diagnosis, the first thing parents need to do is make sure that everyone in the family gets on the same page,” she said, adding that occasional meetings with a family therapist can help. And as the stigma of these illnesses lessens, parents are finding more support groups, school district officials and other community caretakers who can join them in helping children with psychological disorders.

2015 Annual Report Misconceptions about Childhood Suicide

DAVID SHAFFER, M.D. Irving Philips Professor of Child Psychiatry The College of Physicians & Surgeons, Columbia University Chief, Division of Child and Adolescent Psychiatry Columbia University Medical Center 2006 Ruane Prize for Outstanding Achievement in Child and Adolescent Psychiatric Research

Parents may worry about a stray remark about suicide or dangerous behavior among pre-pubescent children, but suicidal thoughts and completed suicides are very rare among young children, said David Shaffer, M.D., Chief of the Division of Child and Adolescent Psychiatry at Columbia University Medical Center. Instead, parents should consider the risk factors for suicide among adolescents, while avoiding some common misconceptions about suicide in this age group.

“…Here are things that you do worry about: risk factors that exist within the family—a family history of suicide; if the kid is drinking a lot, getting drunk—alcohol is a major stimulus of suicide; if there are available methods in the household—a gun collection for example; if there’s any evidence that the child has poor emotional control—if he loses his temper very frequently, or easily gets upset; further, if there are crises, or significant ‘challenges’—it could be an examination, or having to appear in court, or it could be a planned separation by the parents. Such looming events often serve as a marker for a planned suicide,” Dr. Shaffer explained.

There are widespread misconceptions that suicidality “is a permanent mood state,” or that people intending to commit suicide can’t be stopped, Dr.Shaffer said, noting that studies do not support either contention. There is some evidence that adolescents may be influenced to consider suicide in emulation of a famous person or someone in their peer group, he noted, but most people do not act on these feelings.

“But when you have a role model, a famous person who commits suicide, and the press coverage depicts it as a tragedy, and not a crime, it glamorizes the act,” Dr. Shaffer suggested. “I think the moral is, the less talk about suicide, the better. Rather than the reverse. I think most of our work on press coverage supports that.”

Dr. Shaffer said the most important thing parents can do when their child is talking about or threatening suicide “is not to immediately start a dialogue on life and death, but to try and get some understanding of the event that is either looming or has taken place, that is worrying the kid. And then try to work through some options and also to demonstrate support.”

BRAIN & BEHAVIOR RESEARCH FOUNDATION Coping with Anxiety Disorders

DANIEL S. PINE, M.D. Chief, Section on Development and Affective Neuroscience National Institute of Mental Health Intramural Research Program Foundation Scientific Council Member

Although there is “no convincing evidence” that rates of anxiety disorders among children and teens are on the rise, pediatricians and therapists have become increasingly better at identifying and treating the disorders, said Daniel S. Pine, M.D., Chief of the Section on Development and Affective Neuroscience at the NIMH Intramural Research Program.

Like everyone else, children experience some anxiety as a normal part of life, but Dr. Pine said parents should look for three things to know whether their child’s anxiety has become abnormal. “The first and probably the most important thing we look at is whether there is impairment— anxiety that interferes with a person’s ability to function and leads to avoidance,” he said. After that, parents and physicians should look to whether the anxiety causes extreme stress or lasts for weeks or months. There are “no firmly established mechanisms” linking substance abuse and anxiety, Dr. Pine added, but the two disorders may occur together in some teens.

Cognitive behavioral therapy (CBT) and selective serotonin reuptake inhibitor (SSRI) medications seem to be equally effective in treating childhood anxiety, Pine said. “The best study that compared them directly in kids found one is no better than the other, and that combining the two works better than using one or the other alone.” He cautioned, however, that CBT should be delivered by a trained therapist.

Encouraging parents are the key in helping children with anxiety disorders manage their condition, Pine said. “These are parents who can help their kids face the situations that make their children most afraid, and encourage their kids to not avoid the things they’re afraid of. They are parents who look for situations and circumstances and experiences where kids are going to have to deal with their anxiety,” he noted. “Those kids tend to do better with their anxiety compared to kids whose parents are doing absolutely everything they can to prevent their kids from ever getting anxious.”

2015 Annual Report DISCOVERY TO RECOVERY STORIES OF PRODUCTIVE LIVES

People living with mental illness often face numerous challenges in managing their day to day life. Inspired by their unique stories of grace and determination, we acknowledge these challenges and recognize the capacity for families and individuals to persevere and often live productive lives. With the help of both science and the unwavering support of family and friends voice is given to the often silent, closeted and misunderstood illnesses of the brain.

BRAIN & BEHAVIOR RESEARCH FOUNDATION 49

2015 Annual Report Battling the Dragon of Mental Illness

Instilling Hope in Others and in Themselves

Madelin Weiss and Cory Gould have devoted their careers to helping people with mental illness. The two women have never met; their backgrounds and home towns are very different. But both have walked in the shoes of the people they serve. Since childhood, Madelin and Cory have dealt with harrowing mental illnesses that threatened to destroy any hope of a fulfilling future for either.

From age 8, Madelin experienced paralyzing anxiety and depression. Panic attacks made her fearful of going out, “afraid she wouldn’t be able to get back home.” Diagnosed with bipolar disorder at age 11, Cory had completed high school by age 16, but “my smarts didn’t save me from depression,” she says.

Madelin was first misdiagnosed with schizophrenia and given medications that didn’t work. She barely made it through high school and failed twice to get through college. “I spent most of two years in bed,” she says, “getting up only to go to therapy.” She finally found a wonderful therapist and a psychiatrist who prescribed medications that helped her.

For Cory a serious suicide attempt at age 20 turned out to be a “life changer.” She swallowed three times the dose of phenobarbital that should have been lethal. But instead of dying, she woke up a couple of days later, itching all over and thinking how grossly incompetent she was; she couldn’t even kill herself. Then she concluded that there must be mysteries in the universe, and decided to live.

For Madelin and Cory, mental illness is a life-long challenge. Cory pictures her illness as “this ugly little dragon on a chain sleeping in a corner of her brain. Every once in a while, it pulls on the chain, and her vision clouds. I have to pay attention to the early warning signs. I’ve become expert at managing my illness.” As recently as two years ago, Madelin––who calls depression “an outside force from within”–– suffered symptoms severe enough for her to have to stop work. But despite the setbacks and constant vigilance, both women are grateful for the advances in research that have made it possible for them to live productive lives.

Today, Madelin, 64, holds a master’s degree in social work. She is the Associate Executive Director of PIBLY Residential Programs, in the Bronx, New York, where she oversees rehabilitative and support services for several hundred people with mental illnesses. Cory, 58, has a master’s degree in psychology and psychotherapy. She is the go-to mental health professional at Gifford Medical Center in Randolph, Vermont, and a co-founder of the Vermont chapter of the American Foundation for Suicide Prevention.

BRAIN & BEHAVIOR RESEARCH FOUNDATION A Downward Spiral Leads to Uplift

Former NFL Player Helps Others After Facing His Diagnosis

Dreams and reality were always at odds for Keith O’Neil. With a former NFL player for a father and an early love for the game, he always longed to play professional football. But severe anxiety clouded that vision. “I couldn’t sleep at night,” he recalls. “My mind would just keep going.” Around age 12, he began having suicidal thoughts. His parents knew he was moody, but because he would snap out of it, they never suspected an underlying illness. His symptoms receded in high school and resumed in college, while playing college football. Keith turned to alcohol to cope.

Post college his NFL dream came true when he joined the Dallas Cowboys and an old reality resurfaced—constant anxiety. When the Indianapolis Colts picked him up in 2005, Keith realized another dream: playing under revered coach Tony Dungy. But his anxiety worsened. He couldn’t stop thinking about the playbook, yet kept forgetting plays. He worried about days ahead and days past. Keith spoke to Coach Dungy not only about his present mental state but also his lifelong anxiety. Dungy rallied his staff to help. Keith began taking anti-anxiety medication and played on the 2006 Colts Championship Super Bowl team.

His new reality soon came crashing down. In 2010 his wife’s miscarriage triggered a severe manic episode. Following a few days of euphoria, he became paranoid and delusional. Friends and family urged him to seek psychiatric help. Within a week, he was diagnosed with bipolar 1 disorder and began medication. He still faced an uphill battle. Coping with the reality of his illness and medication side effects, Keith sank into an 18-month-long depression that persisted even after the birth of his son in 2012. That summer, Keith met Dr. Steven Dubovsky, a psychiatrist at the University of Buffalo. Dr. Dubovsky prescribed lithium, oxcarbepazine (Trileptal) and aripiprazole (Abilify), which “really made all the difference in the world,” says Keith. “I still deal with my moods but I’m as healthy as I can get.”

In October 2013, he founded 4th And Forever, a nonprofit organization dedicated to raising awareness, providing education, and funding research for mental illness. Through 4th And Forever, Keith is realizing a new dream—easing the way for others and reducing the stigma surrounding mental illness. “I want to do something to help, to say ‘I went through this and it is okay to talk about it.’”

2015 Annual Report DONORS

We are truly grateful for the generosity of caring individuals, foundations, and members of the community that make our work possible.

BRAIN & BEHAVIOR RESEARCH FOUNDATION Research Partners Program

Our Research Partners Program enables donors to select and support a scientist’s project from amongst the most promising, cutting-edge proposals in mental illness research. Sponsoring one year of support for a Young Investigator is $35,000; an Independent Investigator, $50,000; and a Distinguished Investigator, $100,000.

Our Research Partners Program has continued to grow and provide a unique opportunity for critical philanthropic support.

We are deeply grateful to all Research Partners for their vision and leadership.

JAN AND STEFAN ABRAMS ATHERTON FOUNDATION YOUNG INVESTIGATOR Jan and Stefan Abrams Investigators Atherton Investigators Avniel S. Ghuman, Ph.D. University of Pittsburgh YOUNG INVESTIGATOR YOUNG INVESTIGATOR Marta Biagioli, Ph.D. Lior Brimberg, Ph.D. YOUNG INVESTIGATOR University of Trento, Italy The Feinstein Institute for Medical Research Mira Alexandra Jakovcevski, Ph.D. Max Planck Institute for Psychiatry YOUNG INVESTIGATOR YOUNG INVESTIGATOR Yongsoo Kim, Ph.D. Peter G. Enticott, Ph.D. YOUNG INVESTIGATOR Pennsylvania State University Monash University, Australia David L. Roberts, Ph.D. University of Texas Health Science Center at YOUNG INVESTIGATOR San Antonio Brian J. O’Roak, Ph.D. ANNE AND RON ABRAMSON Oregon Health and Science University Abramson Family Foundation Investigators YOUNG INVESTIGATOR SIDNEY R. BAER, JR. FOUNDATION DISTINGUISHED INVESTIGATOR Latha Soorya, Ph.D. Sidney R. Baer, Jr. Investigators John R. Kelsoe, M.D. Rush University INDEPENDENT INVESTIGATOR University of California, San Diego YOUNG INVESTIGATOR Stephen J. Glatt, Ph.D. YOUNG INVESTIGATOR Kaustubh Satyendra Supekar, Ph.D. State University of New York, Upstate Medical Sharmin Ghaznavi, M.D., Ph.D. Stanford University University Massachusetts General Hospital Harvard University YOUNG INVESTIGATOR DIANA AND DAN ATTIAS Brian P. Brennan, M.D. Attias Family Foundation Investigators McLean Hospital Harvard University ANONYMOUS YOUNG INVESTIGATOR YOUNG INVESTIGATOR YOUNG INVESTIGATOR Kelly Anne Barnes, Ph.D. Mark Christian Eldaief, M.D. Chadi Abdallah, M.D. Baylor College of Medicine Beth Israel Deaconess Medical Center Yale University YOUNG INVESTIGATOR Harvard University YOUNG INVESTIGATOR Martin Debbané, Ph.D. YOUNG INVESTIGATOR Gianfilippo Coppola, Ph.D. University of Geneva Mei-Hua Hall, Ph.D. Yale University YOUNG INVESTIGATOR Harvard Medical School Sebastien Delcasso, Ph.D. Harvard University Massachusetts Institute of Technology YOUNG INVESTIGATOR ANONYMOUS YOUNG INVESTIGATOR William B. Ruzicka, M.D., Ph.D. Haddie Investigators Lauren Celia Faget, Ph.D. McLean Hospital YOUNG INVESTIGATOR University of California, San Diego Harvard University Solange P. Brown, M.D., Ph.D. YOUNG INVESTIGATOR YOUNG INVESTIGATOR Johns Hopkins University Jennifer H. Foss-Feig, Ph.D. Eli Ayumi Stahl, Ph.D. YOUNG INVESTIGATOR Connecticut Mental Health Center Icahn School of Medicine at Mount Sinai Julie S. Haas, Ph.D. Yale University YOUNG INVESTIGATOR Lehigh University YOUNG INVESTIGATOR Gordana D. Vitaliano, M.D. YOUNG INVESTIGATOR Allyson Kimberly Friedman, Ph.D. McLean Hospital Theodoros Tsetsenis, Ph.D. Icahn School of Medicine at Mount Sinai Harvard University University of Pennsylvania

2015 Annual Report JANET AND DONALD BOARDMAN YOUNG INVESTIGATOR SUZANNE AND JOHN GOLDEN Janet and Donald Boardman Investigator Jacqueline Morris, Ph.D. Suzanne and John Golden Investigator University of Pennsylvania YOUNG INVESTIGATOR INDEPENDENT INVESTIGATOR Jessica A. Bernard, Ph.D. YOUNG INVESTIGATOR Peng Jin, Ph.D. Texas A&M University Todd F. Roberts, Ph.D. Emory University University of Texas Southwestern Medical Center at Dallas MR. AND MRS. EVERETT DESCHNER GOLDEN RULE FAMILY FOUNDATION Katherine Deschner Family Investigators Golden Rule Family Foundation Investigator FAMILY OF JOSEPH M. EVANS YOUNG INVESTIGATOR Family of Joseph M. Evans Investigators YOUNG INVESTIGATOR Shannon Leigh Gourley, Ph.D. Chun Hay Alex Kwan, Ph.D. Emory University INDEPENDENT INVESTIGATOR Yale University Alessandro Bertolino, M.D., Ph.D. YOUNG INVESTIGATOR University of Bari, Italy Leah H. Somerville, Ph.D. Harvard University YOUNG INVESTIGATOR BONNIE AND ALAN HAMMERSCHLAG Eric A. Epping, M.D., Ph.D. PHILANTHROPIC FUND University of Iowa Hammerschlag Family Investigator ESSEL FOUNDATION YOUNG INVESTIGATOR YOUNG INVESTIGATOR Essel Investigators David P. Gavin, M.D., M.Sc. Shinichi Kano, M.D., Ph.D. University of Illinois at Chicago Johns Hopkins University INDEPENDENT INVESTIGATOR Julia A. Chester, Ph.D. YOUNG INVESTIGATOR Purdue University Sebastien Parnaudeau, Ph.D. Columbia University INDEPENDENT INVESTIGATOR JOHN KENNEDY HARRISON Wen-Jun Gao, M.D., Ph.D. YOUNG INVESTIGATOR John Kennedy Harrison Investigator Drexel University College of Medicine Sarah I. Tarbox, Ph.D. Yale University School of Medicine YOUNG INVESTIGATOR INDEPENDENT INVESTIGATOR Chung Sub Kim, Ph.D. Kirsty Millar, Ph.D. University of Texas at Austin University of Edinburgh, Scotland FAMILIES FOR BORDERLINE YOUNG INVESTIGATOR PERSONALITY DISORDER RESEARCH Wesley Brian Asher, Ph.D. Families For Borderline Personality Disorder HOFMANN TRUST Columbia University Research Investigators Hofmann Trust Investigators YOUNG INVESTIGATOR YOUNG INVESTIGATOR DISTINGUISHED INVESTIGATOR Javier Contreras, M.D. Emily B. Ansell, Ph.D. Angelique Bordey, Ph.D. Universidad de Costa Rica Yale University Yale University YOUNG INVESTIGATOR YOUNG INVESTIGATOR DISTINGUISHED INVESTIGATOR Santhosh Girirajan, M.B.B.S., Ph.D. D. Bradford Reich, M.D. Sohee Park, Ph.D. Pennsylvania State University McLean Hospital Vanderbilt University YOUNG INVESTIGATOR Harvard University Laura M. Harrison, Ph.D. YOUNG INVESTIGATOR Louisiana State University Health Sciences Anthony Charles Ruocco, Ph.D. THE RONA JAFFE FOUNDATION Center, Shreveport Centre for Addiction and Mental Health The Rona Jaffe Foundation Investigator YOUNG INVESTIGATOR University of Toronto, Canada YOUNG INVESTIGATOR Charles Albert Hoeffer, Ph.D. YOUNG INVESTIGATOR June Gruber, Ph.D. University of Colorado, Boulder Kate Eleanor Anne Saunders, B.M., University of Colorado, Boulder YOUNG INVESTIGATOR B.Ch., M.A. Tija Carey Jacob, Ph.D. University of Oxford, England University of Pittsburgh YOUNG INVESTIGATOR KAPLEN FOUNDATION YOUNG INVESTIGATOR Edward A. Selby, Ph.D. Michael F. Kaplen Investigator Roozbeh Kiani, M.D., Ph.D. Rutgers University YOUNG INVESTIGATOR New York University Mariana Pereira, Ph.D. YOUNG INVESTIGATOR University of Massachusetts, Amherst Markita Patricia Landry, Ph.D. Massachusetts Institute of Technology YOUNG INVESTIGATOR David James Margolis, Ph.D. Rutgers University

BRAIN & BEHAVIOR RESEARCH FOUNDATION MIRIAM KATOWITZ AND ARTHUR RADIN Marta Ribases, Ph.D. YOUNG INVESTIGATOR Katowitz/Radin Investigators Vall d’Hebron Research Institute VHIR Jason K. Johannesen, Ph.D. Yale University YOUNG INVESTIGATOR YOUNG INVESTIGATOR Ioana Carcea, M.D., Ph.D. Panagiotis Roussos, M.D., Ph.D. YOUNG INVESTIGATOR New York University School of Medicine Icahn School of Medicine at Mount Sinai Sangwon F. Kim, Ph.D. University of Pennsylvania YOUNG INVESTIGATOR YOUNG INVESTIGATOR Frederick Charles Nucifora, Ph.D., D.O., M.H.S. Jingchun Sun, Ph.D. YOUNG INVESTIGATOR Johns Hopkins University School of Medicine University of Texas Health Science Center at Janghoo Lim, Ph.D. Houston Yale University School of Medicine YOUNG INVESTIGATOR YOUNG INVESTIGATOR CAROLE AND MARVIN LEICHTUNG Simon Trent, Ph.D. Edward O. Mann, D.Phil. Leichtung Family Investigators Cardiff University University of Oxford

YOUNG INVESTIGATOR YOUNG INVESTIGATOR YOUNG INVESTIGATOR Danai Dima, Ph.D. Carmen Varela, Ph.D. Frederick Charles Nucifora, Ph.D., D.O., M.H.S. Institute of Psychiatry/King’s College London Massachusetts Institute of Technology Johns Hopkins University School of Medicine YOUNG INVESTIGATOR YOUNG INVESTIGATOR YOUNG INVESTIGATOR Jacob C. Garza, Ph.D. Qi Wang, Ph.D. Arun K. Tiwari, Ph.D. Massachusetts General Hospital Columbia University Centre for Addiction and Mental Health University of Toronto Harvard University YOUNG INVESTIGATOR YOUNG INVESTIGATOR Joshua D. Woolley, M.D., Ph.D. YOUNG INVESTIGATOR Kanchna Ramchandran, Ph.D. University of California, San Francisco Lingjun Zuo, M.D., Ph.D. Yale University University of Iowa YOUNG INVESTIGATOR Nan Yang, Ph.D. Stanford University EUNICE K. MEYER CHARITABLE LAUREN LEVINE YOUNG INVESTIGATOR FOUNDATION Levine Investigator Wenchi Zhang, Ph.D. Eunice K. Meyer Charitable Foundation Johns Hopkins University YOUNG INVESTIGATOR Investigators Paul Siegel, Ph.D. State University of New York, Purchase College YOUNG INVESTIGATOR Corinna Haenschel, Ph.D. MILTON & TAMAR MALTZ FAMILY City University London FOUNDATION CONSTANCE AND STEPHEN LIEBER Maltz Investigators YOUNG INVESTIGATOR Tara A. Niendam, Ph.D. Lieber Investigators DISTINGUISHED INVESTIGATOR University of California, Davis DISTINGUISHED INVESTIGATOR Bruce M. Cohen, M.D., Ph.D. Claes Wahlestedt, M.D., Ph.D. Harvard University YOUNG INVESTIGATOR Fiza Singh, M.D. University of Miami YOUNG INVESTIGATOR University of California, San Diego DISTINGUISHED INVESTIGATOR Antti S. Alaräisänen, M.D. Suzanne Zukin, Ph.D. University of Oulu YOUNG INVESTIGATOR Jared W. Young, Ph.D. Albert Einstein College of Medicine, Inc. YOUNG INVESTIGATOR University of California, San Diego INDEPENDENT INVESTIGATOR Stefan Ehrlich, M.D. Stanislav S. Zakharenko, M.D., Ph.D. Dresden University of Technology St. Jude Children’s Research Hospital YOUNG INVESTIGATOR NAMI MICHIGAN Herman B. Fernandes, Ph.D. YOUNG INVESTIGATOR NAMI Michigan Investigator Gemma Modinos, Ph.D. Northwestern University YOUNG INVESTIGATOR Institute of Psychiatry/King’s College London YOUNG INVESTIGATOR George McConnell, Ph.D. George Foussias, M.D, M.Sc. YOUNG INVESTIGATOR Stevens Institute of Technology Jess Nithianantharajah, Ph.D. Centre for Addiction and Mental Health Florey Neuroscience Institutes University of Toronto University of Melbourne YOUNG INVESTIGATOR YOUNG INVESTIGATOR Anna Francesconi, Ph.D. Edwin C. Oh, Ph.D. Albert Einstein College of Medicine, Inc. Duke University YOUNG INVESTIGATOR YOUNG INVESTIGATOR Karen J. Gregory, Ph.D. Krishnan Padmanabhan, Ph.D. Vanderbilt University Salk Institute for Biological Studies YOUNG INVESTIGATOR YOUNG INVESTIGATOR Sarah J. Hart, Ph.D. Krystal Lynn Parker, Ph.D. University of North Carolina at Chapel Hill University of Iowa YOUNG INVESTIGATOR

2015 Annual Report NARSAD ARTWORKS MARION G. NICHOLSON YOUNG INVESTIGATOR NARSAD Artworks Investigator Marion G. Nicholson Investigator Veronica Musante, Ph.D. Yale University YOUNG INVESTIGATOR DISTINGUISHED INVESTIGATOR Carol Jahshan, Ph.D. Bonnie L. Firestein, Ph.D. YOUNG INVESTIGATOR Brentwood Biomedical Research Institute Rutgers University Karen M. Ryan, Ph.D. Trinity College, Dublin YOUNG INVESTIGATOR NARSAD RESEARCH FUND OXLEY FOUNDATION Giulia Treccani, Ph.D. Domenici Investigator Oxley Foundation Investigator University of Milan

YOUNG INVESTIGATOR YOUNG INVESTIGATOR Megan Lee Fitzgerald, Ph.D. Haggai Sharon, M.D. Columbia University Tel Aviv Sourasky Medical Center PROJECT HOPE Tel Aviv University Project Hope Investigator YOUNG INVESTIGATOR NARSAD RESEARCH FUND Yingwei Mao, Ph.D. Stephen G. Doochin Memorial Investigator P&S FUND Pennsylvania State University P&S Fund Investigators YOUNG INVESTIGATOR David Louis Pennington, Ph.D. INDEPENDENT INVESTIGATOR Northern California Institute for Research Chadi A. Calarge, M.D. MARC RAPPAPORT and Education Baylor College of Medicine Rappaport Family Investigator University of California, San Francisco YOUNG INVESTIGATOR YOUNG INVESTIGATOR Priti Balchandani, Ph.D. Theodore D. Satterthwaite, M.D., M.A. Icahn School of Medicine at Mount Sinai University of Pennsylvania NARSAD RESEARCH FUND YOUNG INVESTIGATOR Daniel X. Freedman Investigator Mounira Banasr, Ph.D. YOUNG INVESTIGATOR Yale University WILLIAM RISSER CHARITABLE TRUST Christiaan H. Vinkers, M.D., Ph.D. William Risser Charitable Trust Investigators YOUNG INVESTIGATOR Utrecht University Becky Catherine Carlyle, Ph.D. YOUNG INVESTIGATOR Yale University Katie Lynn Nugent, Ph.D. Maryland Psychiatric Research Center YOUNG INVESTIGATOR University of Maryland NARSAD RESEARCH FUND Ramesh Chandra, Ph.D. Gwill Newman Memorial Investigator University of Maryland, Baltimore YOUNG INVESTIGATOR Erik B. Oleson, Ph.D. YOUNG INVESTIGATOR YOUNG INVESTIGATOR University of Colorado, Denver Rachel L. C. Mitchell, Ph.D. Christine Ann Denny, Ph.D. King’s College London Columbia University YOUNG INVESTIGATOR MR AND MRS. CURT ROBBINS Miguel Angel García-Cabezas, M.D., Ph.D. Let The Sun Shine Run Investigator NEW YORK WOMEN’S COMMITTEE Boston University Women Breaking the Silence About Mental YOUNG INVESTIGATOR YOUNG INVESTIGATOR Illness Investigators Ricardo E. Carrion, Ph.D. Dawn F. Ionescu, M.D. Zucker Hillside Hospital, Feinstein Institute for YOUNG INVESTIGATOR Massachusetts General Hospital Medical Research Lynnette Astrid Averill, Ph.D. Harvard University Yale University YOUNG INVESTIGATOR YOUNG INVESTIGATOR Clare Kelly, Ph.D. LINDA AND MARIO ROSSI Estefania Pilar Bello, Ph.D. Trinity College, Dublin Columbia University Chrissy Rossi Investigators YOUNG INVESTIGATOR YOUNG INVESTIGATOR Yevgenia Kozorovitskiy, Ph.D. YOUNG INVESTIGATOR Martine M. Mirrione, Ph.D. Laura K. Fonken, Ph.D. Northwestern University University of Colorado, Denver Cold Spring Harbor Laboratory YOUNG INVESTIGATOR YOUNG INVESTIGATOR Joelle LeMoult, Ph.D. YOUNG INVESTIGATOR Anne Schaefer, M.D., Ph.D. James J. Prisciandaro, Ph.D. Stanford University Medical University of South Carolina The Rockefeller University

BRAIN & BEHAVIOR RESEARCH FOUNDATION SCOTT-GENTLE FOUNDATION YOUNG INVESTIGATOR VITAL PROJECTS FUND INC. Scott-Gentle Foundation Investigator Karuna Subramaniam, Ph.D. Vital Projects Fund Inc. Investigators Northern California Institute for Research YOUNG INVESTIGATOR YOUNG INVESTIGATOR and Education Kazue Hashimoto-Torii, Ph.D. Chadi Abdallah, M.D. University of California, San Francisco Children’s Research Institute (CRI) Yale University Children’s National Medical Center YOUNG INVESTIGATOR EVELYN TOLL FAMILY FOUNDATION Irina Esterlis, Ph.D. Yale University Evelyn Toll Family Foundation Investigators ELLEN SCHAPIRO & GERALD AXELBAUM YOUNG INVESTIGATOR YOUNG INVESTIGATOR Ellen Schapiro & Gerald Axelbaum Jieun E. Kim, M.D. Investigators Lot de Witte, M.D., Ph.D. Ewha W. University University Hospital Utrecht YOUNG INVESTIGATOR Utrecht University YOUNG INVESTIGATOR Christine Elizabeth Gould, Ph.D. Wendy K. Marsh, M.D. YOUNG INVESTIGATOR Palo Alto Veterans Institute for Research University of Massachusetts Medical School, Ragy R. Girgis, M.D. (PAVIR) Amherst Palo Alto Health Care System (VA) Columbia University YOUNG INVESTIGATOR YOUNG INVESTIGATOR R. Matthew Hutchison, Ph.D. Johanna Molly Jarcho, Ph.D. WAREHAM FAMILY Harvard University Stony Brook University School of Medicine Wareham Family Investigator YOUNG INVESTIGATOR YOUNG INVESTIGATOR YOUNG INVESTIGATOR Ting Lu, Ph.D. Jianping Zhang, M.D., Ph.D. Stephanie Dunkel Smith, Ph.D. University of Illinois at Urbana-Champaign Zucker Hillside Hospital, Feinstein Institute for University of Southern Mississippi Medical Research YOUNG INVESTIGATOR Carolyn I. Rodriguez, M.D., Ph.D. Stanford University VAN AMERINGEN FOUNDATION, INC. WEISMAN FAMILY FOUNDATION YOUNG INVESTIGATOR Adam S. Weisman Investigator van Ameringen Investigators Yen-Yu Ian Shih, Ph.D. YOUNG INVESTIGATOR University of North Carolina at Chapel Hill INDEPENDENT INVESTIGATOR Danielle M. Andrade, M.D. Ramin V. Parsey, M.D., Ph.D. University Health Network Stony Brook University School of Medicine University of Toronto VIRGINIA SILVER YOUNG INVESTIGATOR Silver Investigator Sofya Abazyan, Ph.D. Johns Hopkins University YOUNG INVESTIGATOR Eleonore Beurel, Ph.D. YOUNG INVESTIGATOR University of Miami Chihye Chung, Ph.D. Konkuk University YOUNG INVESTIGATOR BARBARA AND JOHN STREICKER Lara C. Foland-Ross, Ph.D. Barbara and John Streicker Investigator Stanford University

YOUNG INVESTIGATOR YOUNG INVESTIGATOR Thomas J. Whitford, Ph.D. Milena Girotti, Ph.D. University of Melbourne University of Texas Health Science Center at San Antonio YOUNG INVESTIGATOR LASZLO N. TAUBER Ramiro Salas, Ph.D. FAMILY FOUNDATION, INC. Baylor College of Medicine Dylan Tauber Researchers YOUNG INVESTIGATOR INDEPENDENT INVESTIGATOR Eric Floyd Schmidt, Ph.D. Alon Chen, Ph.D. The Rockefeller University Weizmann Institute of Science YOUNG INVESTIGATOR Michael L. Lutter, M.D., Ph.D. University of Iowa YOUNG INVESTIGATOR Douglas J. Sheffler, Ph.D. Sanford Burnham Medical Research Center

2015 Annual Report Donors

We are truly grateful for the generosity of caring individuals, foundations, and members of the community that make our work possible.

DISTINGUISHED $250,000+ LEADERS $25,000+ The Rose Mackenzie Trust Mr. and Mrs. Wesley McDonald ANONYMOUS (1) Mr. and Mrs. Stefan D. Abrams Mr. Robert A. McDonald Mr. Gerald Axelbaum and Mr. and Mrs. Donald M. Boardman The Emil and Toby Meshberg Ms. Ellen J. Schapiro Mr. and Mrs. E. Everett Deschner Family Foundation The Carmel Hill Fund Mr. Michael C. Dornan Mr. and Mrs. Mario Montoya The Essel Foundation Dr. and Mrs. Frederick A. Findlen Mr. and Mrs. Rodger L. Nelson Flora Gotz 1998 Trust Golden Rule Family Foundation NewYork-Presbyterian Hospital Gloria Harootunian Revocable Trust Mr. and Mrs. H. Thomas Grimes The Estate of Arthur Ninomiya The Flora P. Klein Trust Mr. and Mrs. Alan Hammerschlag The Irene P. Norell Estate Mr. and Mrs. Stephen A. Lieber Mr. and Mrs. John K. Harrison The Estate of Alfred H. Noren The Estate of Nicholas Major The Rona Jaffe Foundation The Portmann Family Charitable Fund Maltz Family Foundation The Kaplen Foundation Prentice Foundation, Inc. The Dana Marin Trust Barbara T. Leeds Revocable Living Trust Professional Risk Management Services, Inc. P&S Fund Mr. and Mrs. Marvin Leichtung (PRMS) Estate and Trust of Jane H. Rowen Mr. and Mrs. Milton Maltz The Kenneth Rainin Foundation The Walter Kenneth Sartory Family Trust The Carolyn M. Nagel Trust Discretionary Award The Estate of David Schwartz Otsuka America Pharmaceutical, Inc. Mr. Marc R. Rappaport The Estate of Jeanne Ellen Skalsky-Carter The Oxley Foundation Mr. and Mrs. Mario J. Rossi The Estate of Jay Reed West Mr. and Ms. Curt Robbins Ms. Marylou Selo Scott-Gentle Foundation Mr. and Mrs. Sanford Sirulnick Dr. and Mrs. Mark Silver Mrs. Patricia B. Specter Mr. Russell Spangler BENEFACTORS $100,000+ The Starr Foundation Mr. and Mrs. John H. Streicker Mr. Jason Stipanov The Anne and Ronald Abramson Family Foundation Mr. and Mrs. Christopher Wallis Sunovion Pharmaceuticals, Inc. The Attias Family Foundation The John P. and Lois C. Wareham Foundation Supreme Council Benevolent Foundation Sidney R. Baer, Jr. Foundation Ms. Marilyn Waldman The Roger D. Clark Discretionary Trust Suzanne and John Golden PATRONS $10,000+ The Estate of Greta Horn van Ameringen Foundation, Inc. The Helen E. Austin SPONSORS $5,000+ Vital Projects Fund, Inc. Charitable Remainder Trust ANONYMOUS (8) Mr. and Mrs. Robert T. Blanchard Eugene and Carol Atkinson Family Foundation The Blue Oak Charitable Fund Auto Mall Nissan, Inc. Bradshaw Construction Corporation PACESETTERS $50,000+ The Benevity Community Impact Fund Gilbert & Ildiko Butler Family Foundation, Inc. Dr. Scott C. Berk and Ms. Kathryn A. Cannon ANONYMOUS (2) Columbia University Dr. and Mrs. Jeffrey Borenstein Estate of Iris Baranof Mr. and Mrs. Richard A. Edwards Mr. and Mrs. Louis M. Borowicz, Jr. The Mary A. Del Moro Estate Mr. and Mrs. Gary Furness Ms. Sharon E. Bowyer Beth and Rob Elliott Mr. and Mrs. George W. Gephart, Sr. Jeffrey J. and Mary E. Burdge Charitable Trust EOS Foundation Neal and Marlene Goldman Foundation Ms. Sally Cameron Drs. Adam P. and Carol Geballe Mrs. Jean Gollay Dr. and Mrs. Thomas B. Coles HIKE for Mental Health D.W. Gore Family Foundation Command Financial Press Corporation Independent Charities of America Graham Boeckh Foundation Mary Cooney & Edward Essl Foundation The Estate of Lawrence C. Kastin Leona M. Hanselman Trust Will & Ann Eisner Family Foundation, Inc. Carole and Harvey Mallement Mr. and Mrs. Cannon Y. Harvey Envato Pty., Ltd Mr. Arthur J. Radin and Ms. Miriam Katowitz Marilyn G.Harwood Fund Flaxman Family Charitable Trust Renate, Hans & Maria Hofmann Trust Mr. David Hansson and Mrs. Luisa Francoeur and Mr. Jim Goodrich William Risser Charitable Trust Ms. Jamie Heinemeier-Hansson The Joseph and Anna Gartner Foundation The Alice L. Robbins Trust The Henry Foundation Mr. and Mrs. Robert W. Geyer f/b/o Elizabeth Nichols Mr. and Mrs. Larry Hinman Mr. and Mrs. Thomas G. Gillis Roy H. and Natalie C. Roberts Hope Foundation Mrs. Roberta C. Gundersen Family Foundation Mr. and Mrs. Martin B. Jacobs Mr. and Mrs. Arthur W. Hills The R. David Schreiber Amended Trust Jewish Federation of Metropolitan Chicago Horizon Group Properties The Estate of Shirley Shuster JMT Charitable Foundation Mrs. Suzanne C. Hoyt The Evelyn Toll Family Foundation Quentin J. Kennedy Foundation Mr. and Mrs. Thomas C. Israel Dr. and Mrs. Douglas A. Treco The Jan M. & Eugenia Krol Mr. James P. Jamilkowski The Estate of Wylla Vogelgesang Charitable Foundation Janssen Pharmaceuticals, Inc. The Weisman Family Foundation Mrs. Helen Lowenstein

BRAIN & BEHAVIOR RESEARCH FOUNDATION King & Spalding, LLP Mr. and Mrs. Mitchell Becker Mr. and Mrs. Stephen Cummings Mrs. Gertrude Kornfein Mr. and Mrs. Robert Belyea Ms. Betty A. Cuniberti Lavin Family Foundation, Inc. Mr. and Mrs. P. Bruce Benzler Ms. KeriAnn Currlin Mr. and Mrs. Howard Levine Mr. and Mrs. Brian Berger Mr. and Mrs. Hugh P. Curtis Beth Maher Family Foundation Mr. and Mrs. Thomas M. Bergers Mr. John W. Curtis and Ms. Florence C. Mahoney Mr. Nathan Betnun Ms. Margaret A. Sarkela Thomas G. and Andrea Mendell Foundation Mrs. Marilyn M. Bever Dammann Fund, Inc. Dr. Irving Jacobs and Ms. Jeanette Matye Mr. and Mrs. Stephen Binckes Mr. and Mrs. Aaron Daniels Mr. and Mrs. Daniel Mueller Ms. Gail A. Binderman Mr. Trenton A. Davis Gloria Neidorf Charitable Foundation Mrs. Anne L. Bird Mr. Robert J. de Rothschild Gertrude B. Nielsen Charitable Trust Mr. and Mrs. Michael F. Bishay The Estate and Trust of Mary A. DeLeuw Mr. and Mrs. L. David Ricci II Mrs. Michelle Blaskowski The Depressive and Bipolar Disorder The Toby and Nataly Ritter Family Foundation Heather Bleick Memorial Fund Alternative Treatment Foundation Mr. and Mrs. Daniel G. Rodgers Dr. and Mrs. Harold Bloom Ms. Lynn Derman Mr. and Mrs. Eric Rothfeld Bonardi Construction Service, Inc. Mr. and Mrs. Richard K. Descherer Mr. Dan Ryckert Dr. and Mrs. Andrew S. Boral Mr. and Mrs. Richard DeStefano Ms. Sheila Scharfman Boston Financial Data Services, Inc. Mr. David Diffley Mr. and Mrs. Steve Schoolman Mr. Claude Accum and The John D. & Jean E. Dinan Foundation Ms. Cheryl Schweighardt Ms. Diana D. Bradley-Accum Mr. and Mrs. William R. Dodds, Jr. Ms. Yvonne De C. Segerstrom Mrs. and Mr. Donna L. Braun Mrs. Evangeline Douris Seremet Family Foundation Mr. Matthew K. Breitman and Reverend and Mrs. Richard L. Dowling Shortlidge Charitable Trust Ms. Meredith Lawrence-Breitman Mr. Jamie Drake Elinor Beidler Siklossy Foundation Mr. Richard Bretz Dr. Eric M. Dreyfuss The Estate of Eleanor B. Slater Bridgehampton National Bank Mr. and Mrs. Thomas H. Duncan Mr. and Mrs. Daniel A. Small Mr. and Mrs. Peter M. Briscoe Eagles 3208 Gambling Fund Kenneth H. Sonnenfeld, Ph.D., J.D. Bronx Westchester Medical Group Dr. and Mrs. Bennett Edelman Mrs. Lynn G. Straus Mr. James Brook and Julian I. and Hope R. Edison Foundation Team Daniel Running for Recovery Ms. Isabelle Pinzler-Brook Mr. and Mrs. Stephen Ehrlich from Mental Illness, Inc. Ms. Lisa Brown The Estate of Howard Eklind Ms. Barbara Toll The Elise and Andrew Brownstein Ms. Annikki H. Elkind Mr. and Mrs. David Trainer Charitable Trust Mr. Robert C. Elmen Warren County Foundation Depository Mr. and Mrs. John E. Bryson Dr. and Mrs. Bulent Ender Weill Medical College of Cornell University Dr. Katherine E. Burdick Bonnie Englebardt Family Charitable Trust Ms. Karen Zimmer Burke Family Foundation EUE/Screen Gems, Ltd. Mr. and Mrs. Paul T. Burke Richard B. Evans, M.D. The Irving T. Bush Foundation, Inc. Mr. and Mrs. Preston Everdell William F. Byerley, M.D. Mr. and Mrs. Ralph M. Everitt ASSOCIATES $1,000+ Mark Bynum Foundation Fair Lawn High School Mrs. Virginia A. Aaron Ms. Gretchen S. Cahn Mrs. Stephanie Feinland Mr. and Mrs. Celso C. Aberin Mr. James M. Call Ms. Patricia Fernandez Mr. Howard and Dr. Hinda Abramoff PJ Callahan Foundation, Inc. Mrs. Eugenia W. Ferrell Mr. and Mrs. Robert Abrams Law Office of Eileen Caplan Seaman The Fine Foundation Mr. and Mrs. Ron D. Abramson Mr. and Mrs. Paul Carothers Ms. Laura Finn Ms. Mayuree D. Adams Mr. and Mrs. Steven L. Carson FirstGiving Dr. David Adler Mr. and Mrs. Daniel J. Castellani Mr. and Mrs. Gregory Fischbach Mr. Bruce Ahern Castles In the Sky, Inc. Dr. and Mrs. Roger L. Fischer Huda Akil, Ph.D. Mr. and Mrs. Daniel P. Cervelli Rabbi Lyle A. Fishman and Ms. Amy L. Alexander Mr. and Mrs. Gene Cervelli Ms. Debra A. Rosenman Mr. Peter Alexander and Ms. Alison Starling Mr. James O. Shaver and Ms. Christine J. Chao Mr. Kenneth Flanders Ms. Rebecca Amatangelo Charlottesville Area Community Foundation Florida Amateur Driving Club, Inc. (FADC) Ms. Ruth A. Rydstedt and Mr. Ted T. Amsden Mr. Bradley Green and The Framingham Foundation Ms. Mary R. Anderson Ms. Jennifer Chou-Green Mr. and Mrs. Lewis L. French Mr. and Mrs. Edwin F. Anderson Mr. Randolph F. Christen Ms. Helen Friedman The Nancy Andrews Family Foundation Mr. Lloyd Christiansen Mr. and Mrs. Robert A. Funk ANONYMOUS (9) Ms. Barbara L. Chuko Mr. and Mrs. Robert W. Gadsden Mr. and Mrs. Kurt Apen Mr. Mark W. Chutter and Ms. Lorna B. Ellis Ms. Catherine B. Gardner The Nathan Z. Armour Foundation, Inc. Citigroup Business Services Mr. Charles Dale and Ms. Laura Gardner-Dale Mr. Daniel M. Axelbaum CJR Foundation, Inc. Mrs. Nancy S. Geller Ms. Marta K. Bach Ms. Lillian Clagett Mr. and Mrs. Kirk Gellin The Bachmann Strauss Family Fund, Inc. Mr. and Mrs. Craig Clendening Mrs. Jessica Gellineau Mr. and Mrs. Walt Bachman Mr. and Mrs. Michael G. Coles Mrs. Betty B. Giles Ms. Arleen Baez Collins Building Services, Inc. (CBS) Mr. and Mrs. Thomas Gilroy Mr. Stephen Balek Mr. and Mrs. John C. Colman Give with Liberty - Employee Donations Ms. Marybeth Barraclough Mr. George K. Cooney Mr. and Mrs. Ted S. Gladstone Mr. and Mrs. Richard A. Bartlett Corona Lions Universal Foundation, Ltd Goldberg Rhapsody Foundation, Inc. Mrs. Jackie Baumgartner Ms. Judith M. Craig Dr. Alan J. Wasserman and Bayberry Family Foundation Mr. and Mrs. Alan R. Crebo Ms. Susan E. Golick Mr. and Mrs. Michael Becker Mr. and Mrs. Denis F. Cronin Gordon Family Charitable Foundation

2015 Annual Report The Gould-Shenfeld Family Foundation JustGive.org Ms. Katherine H. McNabb Mrs. Martha S. Graham Ms. Carol A. Kallen and Mr. Fred Burrell Mr. Dennis Ladick and Ms. Karen L. Meadows Mr. and Mrs. David A. Gramlich Mr. and Mrs. David R. Kampff Ms. Ellen C. Meadows Granat Family Foundation Mr. and Mrs. Allen S. Kaplan Mr. William Megowen Ms. Sheila Grant Fern Karesh Hurst Foundation Dr. and Mrs. Herbert Y. Meltzer Mr. and Mrs. Bennett G. Grau Mr. and Mrs. Michael J. Kastenholz Mr. and Mrs. Robert Meltzer Mrs. Helen M. Gray Mr. and Mrs. Robert Katz Mr. Jeffrey Menick David E. Green Memorial Scholarship Fund Mr. and Mrs. Steven Katz Robert and Joyce Menschel Family Foundation Mr. and Mrs. Kevin M. Greene Ms. Sandra Kazlow Merevill Foundation Mr. and Mrs. Jesse J. Greene, Jr. Mr. and Mrs. William A. Keller Mr. and Mrs. Bernard Meyers Mrs. Margaret E. Grube Ms. Judith S. Kelly The Miami Foundation Ms. Renee M. Cassidy and Mr. Romel R. Khan Microsoft Matching Gifts Program Mr. Jordan D. Gushurst Mr. Kevin Kielbasa Mr. and Mrs. Paul D. Miller Mr. and Mrs. Rob Gushurst Ms. Yvonne S. Kilbourne Ms. Marianne Miller Diane Acker Haber, M.D. Mr. and Mrs. Ronald D. Killough Jean Audrey Miller Estate Ms. Jennifer M. Haddox-Schatz Ms. Elizabeth N. Kimball Mr. and Mrs. Michael E. Miller Mr. and Mrs. Roscoe O. Hambric, Jr. Mrs. Manisha Kimmel Ms. Constance Miller Mr. and Mrs. Carl S. Hammer Mr. and Mrs. Ira D. Kleinman Mr. and Mrs. Michael Minikes Mr. and Mrs. Norm Harper Mr. Michael Klingher MJS Foundation, Inc. Ms. Mary Jo S. Harrison Ms. Miral Kotb Mr. J. Clifford Moos Mr. James M. Harshman Ms. Ellen Krantz The Alfred L. Morse and Ms. Harriet M. Hart Mrs. Esther W. Krebs Annette S. Morse Foundation Mrs. Esther M. Hartman Mr. and Mrs. Michael Krejci Ms. Lauren Morton Mr. Jason Hawk Mr. and Mrs. Howard G. Kristol Mr. and Mrs. Marcel Mouney Dr. Samuel E. Hazen Mr. and Mrs. Ted Krolikowski The Alfred C. Munger Foundation Mr. Joseph P. Cothrel and Ms. Linda A. Heban Richard J. Kruger Foundation Mr. Eric Murchison Mr. and Mrs. Albert P. Hegyi The Kupferberg Foundation Mr. James J. Murphy, Jr., Mr. Michael K. Herman The Kenneth & Harriet Kupferberg Ms. Mary Webster-Murphy and Mr. and Mrs. Richard W. Hillon Family Foundation Ms. Emily W. Murphy Ms. Mary P. Hines Jack & Dorothy Kupferberg Family Foundation NAMI - Genesee County Mr. and Mrs. David A. Hirsch The Jesse & Joan Kupferberg NAMI - LAMP / SW Nassau NY, Inc. Mr. and Mrs. Ralph J. Hitchcock Family Foundation NAMI Newton Wellesley Eastern Mass, Inc. Mr. and Mrs. Hal B. Hollister Mr. and Mrs. J. Wesley Kussmaul Mr. Venicio Navarro Mr. Tyler Holt Mr. and Mrs. Jim R. Lahti Network For Good Honokohau Properties Mr. and Mrs. Alan Landis Arthur C. Nielsen, Jr. Charitable Trust Mr. Steven J. Hopp and Ms. Palmer Robinson Mr. and Mrs. Guy Lanquetot Mrs. Michiko Nielsen Barry H. Horowitz, C.P.A., M.S.T. Mr. and Mrs. David Laubach Mr. and Mrs. David Noack J.S. Howe Family Foundation Ms. Joan M. Lechner Mr. Kenneth G. Witte and Ms. Gail Noah M.S. Howells Foundation Mr. and Mrs. Burton L. Lehman Mr. and Mrs. Richard Novick Anne S. Howells Charitable Trust Ms. Annie F. Levine Mr. and Mrs. Timothy O’Keefe Mr. and Mrs. George H. Hume Mr. and Mrs. Daniel Levy Mr. David O’Keefe Mr. and Mrs. Scot W. Humphrey Mrs. Ellen F. Levy Once For All Trust, Inc. Mrs. Hazel Hundert Dr. Edward Libby Mrs. Angela N. Palma Rita G. Hungate, M.D. Ms. Devra Lieb Dr. Herbert Pardes and Dr. Nancy Wexler Ms. Sarah M. Hunt Ms. Mary M. Lieber Mrs. Bonnie A. Parker Mr. and Mrs. Michael J. Hurley, Jr. Robert J. Lieber Charitable Trust Dr. and Mrs. Roderic A. Parnell, Jr. Mrs. Gail J. Hurvitz Lieber Institute, Inc. Mr. and Mrs. S. Giles Payne Mr. and Mrs. Craig Hutson Mr. and Mrs. James Locatelli Ms. Megan J. Paznik Ms. Claudia Huzar Mr. John Lohmeier Dr. Arthur Peck Mrs. Mary T. Ingriselli Mr. and Mrs. Harvey S. Long Mrs. Mary J. Pedrosa Mr. and Mrs. Louis Innamorato The Lookout Foundation, Inc. Dr. Robert J. Perlmutter and The Ironman Foundation, Inc. Mr. Dan C. Lortie Mrs. Rachel M. Perlmutter Mr. and Mrs. Norman Isler Mr. Alan Lowry Dr. Bruce D. Perry Dr. and Mrs. Mervyn Israel Mr. and Mrs. Andy Lueck Mr. and Mrs. Seymour Pestronk Ms. Allyson Izzo Mrs. Cynthia Luppen Mr. Jerome W. Pickholz J Squared Press, Inc. Ms. Cheryl MacLachlan and Dr. Richard N. Pierson J.R. Realty Corporation Mr. Fred S. Gorelick Mr. Daniel Pipinich Mrs. Vivian B. Jackson Mr. Donald Chin and Ms. Grace Mah Mr. Alex Porter John Mary & Bernard Jacobs Foundation Mr. and Mrs. Joseph K. Maiuro Mrs. Pam Pour The Jacobson Family Foundation Mr. Robert D. Martin Premier Store Fixtures, Inc. Mr. Niles Jager Ms. Susan Q. Martin Mr. Roger Prior and Dr. Barbara A. Page Mr. and Mrs. Thomas B. Jahncke Mr. and Mrs. Josiah L. Mason Mr. and Mrs. Grant E. Propper Ms. Carolyn R. Jakopin Dr. and Mrs. Sanjay Mathew Mr. and Mrs. Bradley Provisor Mr. and Mrs. Arthur Janousek Maureen’s Kitchen, Inc. Ms. Susan P. Quasney Mr. and Mrs. Dennis W. Jereb Helen S. Mayberg, M.D. Mr. and Mrs. Stephen F. Quinn Mr. and Mrs. Mitchell Johnson Mr. and Mrs. Thomas R. Mayer Quontic Bank Mr. and Mrs. Peter S. Jonas Ms. Elizabeth M. McCarthy Dr. and Mrs. Mohammad E. Qureshi The Bevan Jones Memorial Trust Ms. Jolynne McDonald Mr. Jordan Raisher

BRAIN & BEHAVIOR RESEARCH FOUNDATION Mr. Anthony R. Rando Mr. Jordan Sorensen Dr. and Mrs. Martin S. Willick Mrs. Margot E. Razziano Mr. and Mrs. Lawrence I. Sosnow Ms. Phoebe Wilson Ms. Nancy Reeve Mr. and Mrs. Ted Spetnagel Mr. and Mrs. John Winter Mr. Gary Reeve Ms. Cullen Stanley Mr. and Mrs. Richard Wittenberg Mr. Duane Reid Ms. Susan E. Stanton Mr. and Mrs. Kenneth Wood Mr. and Mrs. Sheldon M. Rein Ms. Elizabeth Steele Dr. and Mrs. Stephen C. Woodward Ms. Rebecca A. Rein Mr. and Mrs. Kenneth T. Steele World Heritage Foundation Ms. Faye H. Rencher Mr. and Mrs. Richard Steinberg Ms. Jean Yim Mr. and Mrs. William G. Rhoads Ms. Claudia C. Stewart Mr. Kenneth Young Lawrence I. & Blanche H. Rhodes Memorial Mr. Gregory Stilwell YourCause, LLC Fund, Inc. Mr. and Mrs. John I. Stites Mr. and Mrs. James N. Zartman Ribbons for Research Mr. and Mrs. Ronald V. Stone Mr. and Mrs. David T. Zimmer Mr. and Mrs. Joseph J. Ricci Mr. and Mrs. Richard Strasbaugh Mr. and Mrs. Philip Zimmerman Ms. Rhoda G. Rice Peggy Straw Advised Fund Mr. and Mrs. Thomas A. Zimmerman Ms. Julie W. Richardson Mr. and Mrs. Timothy E. Stutzman Ms. Jennifer Ricketts Dr. and Mrs. Myron Susin The Robbins Family Foundation The Elaine Swann Estate SUPPORTERS $500+ Max Robinowitz, M.D. and Mr. and Mrs. Frank H. Swanson Carolyn B. Robinowitz, M.D., Ph.D. Ms. Lurline L. Sweet Mr. and Mrs. Roger S. Aaron Mr. and Mrs. Roland Rofé Mr. and Mrs. Gordon Tagge Susan Abbott, M.D. Mr. Kevin Rogers Taking Strides Against Mental Illness Mr. and Mrs. Walter S. Abbott Dr. and Mrs. Alain Roizen Ms. May-Ling Tang Mr. and Mrs. John S. Abrams Ms. Kathleen F. Rorick-McNichol and Mr. Charles M. Tatham and Mr. and Mrs. Salman Ahmed Mr. James D. McNichol Ms. Joanne Adamko-Tatham Mr. Maynard Akkerman Mr. and Mrs. Robert B. Rosen Mr. and Mrs. William B. Tausig Mr. and Mrs. Edward Albers Ms. Raquel Ross Mrs. Elizabeth J. Taylor Mr. and Mrs. Stuart Albrecht Mrs. Donald I. Roth Mr. Jorgen Thelin AmazonSmile The Lewis Roth Family Foundation Ms. Rita Thrasher Dr. Audrey S. Amdursky Dr. George Rozanski Mr. and Mrs. Glen A. Tobias Ameriprise Financial Mrs. Carol A. Rudder Ms. Linda D. Tosti Amgen Pac - Matching Gift Program Mr. Jeffery L. Rutherford Travelers Insurance Mr. David Anderson RZ Foundation Ms. Andrea Trewyn-Strom Mr. John R. Anderson Mr. and Mrs. John Safko Mr. and Mrs. Timothy C. Tuff Mr. Matthew Anderson Mr. and Mrs. Reuben H. Saideman Ms. Clara M. Ueland and Mr. Walter McCarthy Dr. and Mrs. Michael R. Andreychik Ms. Willmetta P. Saldin United Way of Milford ANONYMOUS (3) Ms. Mary C. Salpukas United Way of the Columbia-Willamette Lauren B. Anthone, LLC Jack & Anita Saltz Foundation United Way, Inc. Mr. Andrew K. Antwih Jos. T. Samuels, Inc. Mr. and Mrs. Leo Urbanske Apple Bank Dr. William E. Sanson Vanguard Charitable Endowment Program Mr. Rollin A. Armer Mr. and Mrs. Richard Schaps Mr. Duane Vermazen Mr. and Mrs. Frank G. Arnstein Mr. Peter Scheidler Viking Global Foundation, Inc. AT&T United Way Employee Giving Campaign Anthony A. Schmidt Family Foundation Visa Giving Station / Frontstream Autism Science Foundation (ASF) Mr. E. James Morton and Mr. Robert W. Vogel Autism Speaks, Inc. Ms. Matthild C. Schneider Mrs. Florine D. Vrooman Mr. Bruce W. Baber Mrs. Ruth B. Schoenrock Mr. and Mrs. Steven R. Wagner Mr. and Mrs. Thomas J. Bak Nina R. Schooler, Ph.D. Mr. and Mrs. Robert R. Walker III Mr. Brian Baker Mr. Daniel J. Schreiber Ms. Penny Wallerstein Mr. James G. Banghart Schwab Charitable Fund WalMart/Walmart Foundation Bank of America Foundation Mr. Marc A. Schwartz Mr. Paul M. Warner Mr. and Mrs. David O. Barrows Dr. Lloyd I. Sederer and Ms. Rosanne Haggerty Mr. and Mrs. Richard Warren Mr. and Mrs. David Barry The Jean and Charles Segal Foundation Ms. Sherry Warren Dr. and Mrs. John R. Baudler Mr. and Mrs. Dennis M. Seremet Ms. Deanna Watson Mr. and Mrs. Dennis Baylor Mr. and Mrs. Steven C. Shachat Ms. Sheri C. Wechsler BDO USA, LLP Dr. and Mrs. Sherman Shapiro Theodore & Renee Weiler Foundation, Inc. Mr. and Mrs. William J. Beard Ms. Barbara H. Shapiro Mr. and Mrs. Stephen Weinberg Mr. James Beer Mr. and Mrs. John L. Sheldon John L. and Sue Ann Weinberg Foundation Ms. Clara Bennett Dr. and Mrs. Kenneth Shestak Mr. and Mrs. Louis Weisman Marilyn B. Benoit, M.D. The Sibley-Saltonstall Charitable Foundation Dr. Myrna M. Weissman Mr. and Mrs. Elliot Berger Mrs. Lilian Sicular Mr. and Mrs. Harvey Wertheim Ms. Amy Berko-Iles Mr. Kenneth Siegel Mr. and Mrs. Michael B. West Mr. and Mrs. Herbert Bernard Silicon Valley Community Foundation Dr. and Mrs. James D. Westhoven Mr. and Mrs. Gene Bernardoni Ms. Alesha Sim The Westport Fund Wendy L. Biderman, Ph.D. Mrs. Marcia Simon-Kaplan Harold Wetterberg Foundation Mr. and Mrs. John C. Binder Mr. and Mrs. Neil Singla Mrs. Phyllis Whisler Mr. David D. Boes and Mr. and Mrs. John B. Sisk Mrs. Virginia J. Whitcombe Ms. Martha Mayes-Boes Mr. Richard M. Smith Mrs. Beverly A. White Ms. Roberta Bogen Mr. Ian Smith and Ms. Joanna Oltman-Smith Mr. John P. Wierzba and Bondee Enterprises, Inc. Mrs. Barbara R. Smith Ms. Ruth A. Lane-Wierzba Dr. and Mrs. Benje Boonshaft

2015 Annual Report Ms. Susan G. Boorse Mr. Roy Dykes Mr. Jack Harkins Mr. and Mrs. Norman H. Bouton Jr. Ms. Mary Eaton Mr. Christopher L. Harper Mr. Jonathon Brandt Ms. Hope A. Egan Mrs. Claudine M. Harris Dr. Glen Brennan Mr. Davis Einhorn Dr. and Mrs. Michael S. Harrison Ms. Dale L. Brodsky Mr. and Mrs. Stephen Eisenstein Mr. William P. Harrison Mrs. Pamela G. Brown Mr. and Mrs. Michael G. Eller Mrs. Martha P. Harrison Dr. Carl N. Brownsberger and Elliott Management Corporation Harvard Business Services, Inc. Mrs. Susan Brownsberger Mr. Gary P. Elliott Mr. Benjamin J. Haskin Dr. and Mrs. William J. Brownstein Mr. Charles Eng Ms. Linda J. Havlin Mr. and Mrs. Craig G. Bruckner Mr. Peter Engeian Mr. John J.H. Phillips and Ms. Carolyn Healy Mr. and Mrs. James E. Buckman Eye Spy Investigations, Inc. Ms. Phyllis Heischuber Ms. Allison Burke Ms. Kate S. Ezra Hempstead Auto Sales, LLC Mr. and Mrs. Charles Callahan III Ms. Mary Ellen Falk Dr. Aude I. Henin Ms. Sarah Callender Mr. Pedram Farahnak Ms. Susie Herb Camp Hopson of Newbury Funerals Hyman & Susan Feldman Family Foundation Mr. and Mrs. Richard W. Herbst Mr. Blayne Cannon Fenwick & West, LLP Mr. and Mrs. Henry L. Herman Mr. and Mrs. Gerald Capodieci Fidelity Investments Charitable Gift Fund Mr. Richard W. Hewetson Mr. Roderick D. Carroll Fierce Dragon Martial Arts Academy Mr. and Mrs. Marvin L. Higgins Ms. Jill M. Chapman and Mr. Richard K. Allen The Fifth Floor Foundation David A. Hildalgo, M.D., P.C. Ms. Rebecca Chen Ms. Anne Finestone Mr. and Mrs. Charles Hill Dr. and Mrs. Michael J. Clune Ms. Jennifer A. Fischer Ms. Saralee G. Hillman Mr. and Mrs. Martin Cohen Mr. David Fitzgerald Mr. and Mrs. Charles E. Hilton Mr. and Mrs. Michael S. Cohen Mr. Michael Fitzsimmons Ms. Ruth A. Hodges and Mr. John A. LeClaire Columbia Association of the Department of Ms. Jacqueline Flaherty Mr. Jordan Hoffman Sanitation, Inc. Ms. Margaret A. Flanagan Mr. Timothy A. Hood Mr. and Mrs. William F. Conger Mr. Thomas H. Flanders Ms. Sheryl L. Howe Mr. and Mrs. John J. Cooney, Sr. Mrs. Margaret A. Flynn Mr. and Mrs. Peter Howell Ms. Eva Cooper Ms. Letitia W. Ford HPM Corporation Mr. and Mrs. Curtis H. Cornwell Mr. and Mrs. Thomas Frayda Mr. Robert C. Hunter Mr. Timothy Cosgrove Ms. Colleen A. Frobose Mr. and Mrs. John A. Hurvitz Ms. Lisa Coyle Diana Furrow, LPC Dr. Donald E. Hutchings Dr. Margaret Crastnopol Dr. Wen-Jun Gao Ms. Emily R. Hyun Ms. Cynthia J. Crawford Mr. and Mrs. David L. Gardner Mr. and Mrs. Robert Ianni Ms. Sylvia J. Creamer Ms. Ursula S. Gassner Mr. and Ms. Gary Ickowicz Mr. Daniel E. Cromie Ms. Nancy S. Gear Instinet Ms. Barbara L. Cruse Mr. Jeffery Gerbitz J.M.A. Foundation Ms. Johanna S. Cummings Ms. Carolyn Gero Mr. and Mrs. Jeffrey A. Jackson André & Marilyn Danesh Fund Jay N. Giedd, M.D. Mr. Eric M. Jackson Mr. Sigmund E. Davidson Givalike.org / Donatic.org Mr. and Mrs. Thomas A. Jacobs Mr. and Mrs. Gary A. Davis Mrs. B. Judith Glassman Mr. and Mrs. Sidney S. Jacobson Mr. and Mrs. Lawrence E. Davis Mr. and Mrs. Jack Gold Mrs. Marion Jamgochian Dr. Jan De Bakker and Mrs. Gerarda De Bakker Mr. and Mrs. Jay Goldberg Mr. and Mrs. Schuyler W. Johnson Mr. Henry DeAngelis, Jr. Mr. Jacob Goldblatt Mr. and Mrs. Jeffrey S. Johnston DeBartolo Family Foundation, Inc. Mr. and Mrs. Richard S. Goldman Mr. David O. Jones Mr. and Mrs. Dennis F. Deely Good Samaritan Hospital Mr. and Mrs. Kyle Jones Mr. and Mrs. Gaspare R. DeGaetano Mr. Mark Gavin and Ms. Jodi Goodman Ms. Mary E. Jones Dr. José DeLeon and Ms. Victoria Martinez Michael and Lola Goodstein Charitable Mr. Patrick Jones Mr. and Mrs. Dale A. Dellutri Foundation Trust Mr. and Mrs. Robert R. Kain Ms. Drusilla D. Demmy and Ms. Laurie L. Gordon Mr. and Mrs. Joseph J. Kaminski Mr. Henry E. Bowden Ms. Laila Gordy Ms. Kathe Kane Mr. and Mrs. Robert E. Denham Mr. Chris Gospodnetich Mrs. Meenakshi Kanuganti Mr. Timothy B. Dewald Ms. Lorri Grainawi Mr. Robert L. Karczewski Diligent Board Member Services, Inc. Mr. and Mrs. Arthur M. Gray Mr. and Mrs. Peter D. Kaufman Diligent Credit Solutions, Inc. Mr. Kevin Gray Hale and Andrea Kell Ms. Rose F. DiMartino Mr. Francis Green and Mr. and Ms. Justin R. Kerker Mr. Nathan Dixon Ms. Barbara Geiger-Green Mr. Jeffrey Kersten Ms. Elsie M. Doss Mr. and Mrs. Robert J. Greenberg Mr. and Mrs. David L. Kieper Mr. Herman Drabenstott Mr. Andrew Greenhalgh Ms. Sandra K. Killough Mr. and Mrs. Robert L. Drake Ms. Lynn Griffin Mr. Robert A. Kindler Mr. Michael S. Dreyer Dr. and Mrs. John M. Grohol Mr. and Mrs. Lawrence D. Kingsley Mr. Mathew Drinkwater and Dr. Michael Grunebaum and Ms. Ruth Graver Mr. William H. Kirby and Dr. Lenore S. Kirby Dr. Adrienne Drinkwater Mr. and Mrs. Anthony Guagenti Mr. and Mrs. Frederick P. Koehler Mr. John Duda Mr. Reggis Guthrey Kokomo Urology, Inc. Mr. and Mrs. Daniel Dugan Mr. and Mrs. Paul G. Haaga, Jr. Mr. Madhuri Kondepudi Mr. and Mrs. Josh Duitz Mr. and Mrs. William R. Hacker Mrs. Helen P. Koskinas Dukas Public Relations, Inc. Dr. and Mrs. William H. Hague Mr. and Mrs. Boris Kotler Dulinski Family Foundation Mr. and Mrs. Jerry M. Hamovit KPMG - Matching Gifts Program Dr. and Mrs. Ronald S. Duman Ms. Chance Harenza Mr. and Mrs. William L. Kring

BRAIN & BEHAVIOR RESEARCH FOUNDATION Mr. and Mrs. Gwilym R. Kroll Mr. Henrik S. Olson and Ms. Alisha Shudy Mr. and Mrs. Werner Kroll Ms. Deborah M. Mesmer Mr. David R. Sicular and Drs. John H. Krystal and Bonnie Becker Mr. and Mrs. Richard J. Orr Ms. Lilian Stern-Sicular Mr. Shane Kucera Ms. Nancy J. Ouimet Mr. Jeffrey M. Siegal The Estate Kathleen R. Kuehlhorn Mr. and Mrs. Leonard J. Owen Mr. Andrew P. Siegler Ms. Rohila Kusampudi Mrs. Susan P. Palmer Mr. Daniel Simon Mr. Hani Kuttab Mr. and Mrs. Anthony Pardo Mr. Dan Simon Mr. and Mrs. Walter J. Lafferty Mr. Tom Parker Joseph T. & Helen M. Simpson Foundation Drs. Robert S. and Ann C. Laitman Ms. Kathie M. Parker Dr. Kathryn Smith Mr. and Mrs. George Lantos Mr. and Mrs. George E. Pawlowski Ms. Margaret E. Sokol Lardo Hawthorne Mr. Leland R. Payton Sonu Anand Designs Mr. Paul Larson Mr. Jesse M. Abraham and Mr. John D. Soriano Ms. Dianne C. Leech Ms. Amy Peck-Abraham Ms. Linda Spielman Steven M. Lehmer, M.D. Mr. Robert F. Perry Ms. Maya Spivak Mr. Leif LeLoup Mrs. Marion F. Philips Mr. Ryan J. Stacklin Ms. Kathryn Lesh Mr. Scott R. Pickham Ms. Julie Stafford Ms. Karen Levine Dr. Lesli Preuss Mr. Jimmie Stapleton Mr. and Mrs. Kirk Lider Mr. and Mrs. Brad A. Purifoy Mr. Tod D. Stephens Mr. and Mrs. Lewis J. Liman, Esq. Mr. and Mrs. Daniel Quiat Mr. and Mrs. Brent Stewart Mr. and Mrs. Michael D. Logan Mr. and Mrs. John J. Quinn Mr. Michael M. Stoaks Ms. Clara F. Londoner Ms. Mary A. Radpour Sunrise Automall, LLC Mr. Leonard Lowengrub and Ms. Ramya K. Raghavan Ms. Marilyn J. Tabor Ms. Ilana Goor-Lowengrub Ms. Elizabeth A. Redmond Mr. and Mrs. David W. Talsma Ms. Ann Lowry Mr. Charles Reed Taylor Survivor’s Trust Ms. Isabella Lubin Mr. Eric M. Hershberg and Ms. Judy E. Rein Mr. and Mrs. José L. Tellez Mr. and Mrs. Carl A. Lund Ms. Marleta Reynolds Ms. Judith Tenzer-Benn Mr. and Mrs. Richard Lynch Rhythm n’ Notes Club Texas A&M University (TAMU) Mr. and Mrs. Morgan E. Lytle Ms. Margaret A. Ricketts Theatrical Stage Employers Mr. and Mrs. Robert Maggi Dr. James F. Riddle Mr. Ernest L. Thomas Dolores Malaspina, M.D. Mr. and Mrs. Don Rigoni Mrs. Esther F. Trachtman Mr. and Mrs. Robert Mandel Mr. and Mrs. Simran S. Rihal Ms. Kathy Trembley Mr. and Mrs. Charles L. Marburg, Jr. Mr. Frederic W. Ripley and Ms. Sharon Kirby Ms. Fay M. Trowbridge Mrs. Alison C. Marer Ms. Stephanie Riven and Mr. Roger Goldman Mr. and Mrs. Michael D. Tusiani Mr. and Mrs. William G. Martens III Mr. Brian A. Robbins Mr. and Mrs. Barry Uhlich Mr. John G. McCarthy Mr. and Ms. Edward Robinson Mary C. Uricchio, M.D. Mr. and Mrs. Ward McNeilly Mr. and Mrs. Andrew Rockett Mr. Deepak Vaishnav Mr. and Mrs. David B. Merchant Ms. Debra S. Rose We Support Paul Vallone Mr. Douglas R. Merritt Dr. and Mrs. Marvin Rosenberg Vallone & Vallone, LLP Meseron Sales Corporation Mr. and Mrs. John Ross Dr. Margaret R. van Horn and Mr. David J. Metcalf Mr. and Mrs. Michael R. Rothman Mr. Paul E. van Horn Dr. Michele L. Miles Mr. and Mrs. W. F. Rousseau Ms. Pam Vestal Ms. Kimberly E. Millen Mr. Joshua Rubin Mrs. Virginia Vitarello Millennium Hyundai, LLC Mr. and Mrs. Donald Rully Mr. and Mrs. Kurt J. von Boeselager Millennium Telemanagement, Inc. Mr. Patrick Ryan Mr. and Mrs. Gregory von Briel Mr. and Mrs. Richard Miller Mr. James A. Sadewhite Ms. Karen L. Watson Dr. and Mrs. William J. Mitchell Mr. and Mrs. Dharmbir Saini Mr. Joshua Weier Mr. and Mrs. Michael T. Mitchell Salesforce.org - Champion Grants Ms. Helene S. Weiss Mr. and Mrs. Wendell C. Mohr Sanitation Officers Association Wells Fargo Community Support Campaign Dr. Enrique H. Monsanto and Ms. Judith K. Hall and Mr. Donald S. Sargent Mr. and Mrs. Thomas C. White Dr. Barbara Winkler-Monsanto Mrs. Harriet R. Sarkaria Ms. Liesl A. Wiederkehr Ms. Jane V. Montecillo Dr. Herbert J. Schlesinger and Mr. and Mrs. John Wiegmann Mr. and Mrs. Frank E. Morgan Dr. Ann H. Appelbaum Mr. and Mrs. Raymond Williams Mr. and Mrs. Rob Morrill Mr. and Mrs. Richard J. Schlueter Mr. and Mrs. Steven C. Wills Mrs. Mary V. Mortelette Mr. and Mrs. Leonard Schneider Mr. and Mrs. Rick Wilson Mr. and Mrs. Paul V. Mosher Ms. Constance Schnuck Mr. Zachary Wobensmith Mr. and Mrs. William Muir Mr. and Mrs. Edward J. Schoenecker Mr. and Mrs. Richard A. Wolfe Municipal Credit Union (MCU) Mrs. Linda S. Schwenk Mr. Adam Wolfson Mr. John F. Mussman Ms. Joann Schwentker Drs. Michael and Abby Wolk Ms. Rita Nalebuff Ms. Laurie Scudder Amy J. Worrell, VMD NAMI - FACE of Burlington County Mr. and Mrs. Matthew Seitz Mr. and Mrs. Charles R.B. Wright NAMI - Pittsburgh South Mr. Jared N. D. Selengut Mr. and Mrs. Joseph Wright, Jr. NAMI - Saint Cloud Area Ms. Tara H. Shani Ms. Joanne C. Yablonsky NAMI - San Joaquin County Ms. Jean C. Sheller and Mrs. Roberta Fricker Mr. William Yin Mr. Steven Nelson Mr. Pauline Shender Ms. Beverly Zabel Ms. Verna M. Nelson Dr. Miriam Shenfeld Ms. Judith Zartman Newbury Animal Hospital Dr. Ben Shepherd The Zorn Foundation Mr. Scott Nocas Mr. and Mrs. John Shields Mr. and Mrs. James M. O’Donoghue Mr. and Mrs. David B. Shippey

2015 Annual Report Matching Gift Companies

Allstate: The Giving Campaign Goldman, Sachs & Co. Matching Gift Program Silicon Valley Community Foundation/ American Express Foundation Hudson-Webber Foundation eBay, Inc. Foundation Amgen Pac Matching Gift Program JMT Charitable Foundation TCF Foundation Bank of America Foundation John Hancock Financial Services The Amgen Foundation Staff Giving Programs BNY Mellon Community Partnership Matching Gifts Program The Benevity Community Impact Fund/ Anne E. Casey Foundation Eli Lilly & Company Foundation, Inc. Benevity Social Ventures, Inc./ Matching Gift Program Matching Gifts Program American Endowment Foundation Charles Schwab Foundation Matching Gift Center Thomson Reuters Chubb & Son, Inc. The Merck Foundation UBS ConocoPhillips Matching Gifts MFS Investment Management United Way of Tri-StateTruist/Truist Connect Deutsche Bank Americas Foundation Matching Gift Program Visa Giving Station/Frontstream The Duke Energy Foundation Microsoft Matching Gifts Program WalMart/Walmart Foundation Matching Gifts Program Mutual of America Foundation Wellington Management Company, LLP FM Global Foundation NYSE Euronext Foundation, Inc. Matching Gift Program The GE Foundation Matching Gifts Program Matching Gifts Program YourCause, LLC Give with Liberty Employee Donations Pfizer Foundation Matching Gifts Program GlaxoSmithKline Foundation Rinet Company, Inc. Tributes

Honor Tributes A loved one Alexander Berger Mr. and Mrs. E.H. Carter Lex Doyle Rose J. Aaron’s family Bernadette (pet) John R. Caruso The Drake Family All those dealing with Ellen Bernstein Charles and Deanea Causey Gail Drescher mental conditions Sandie Bernstein Abbey Chakalis Britney Duffy-Alberto All those fighting mental illness Frederick Bird Sho Tin Chen Lauren R. Duran All suffering from Schizophrenia John J. Birkenhier Ben Chinitz Marta Edmisten All the Artists of the Jenny A. Blanchard, D.O. Molly I. Chodakewitz Edward Brainwave Music Album Gabriel Bloom Keith and Louise Christensen Elaine Loved ones affected by Irene Bodden CODAC Behavioral Health Freddie El-Khoury mental illness The Bodnar Family Services, Inc. Habib El-Khoury Jane L. Allison Kimberly Boehm Nicholas Coffey The Ernst Family Andrew and Nicole Ann Bolton Alison Cohen Farrish Evans Anna Heather L. Bolton Jane Moos Cohen Jennifer M. Evans Carol Ansell Marilyn Bolton Jonathan D. Cohen, M.D., Ph.D. Eydis Eysteinn Edward Arvey June Bond Adam Coles Jonathan D. Falk Dr. Steven Atlas Garrett Boorman Peter G. Coles, M.D. Jason and Paula Feinstein Mercedes Austgen Jeffrey Borenstein, M.D. Thomas B. Coles, M.D. Harvey and Sally Fischman Whitney Avers Katy Bowen-Campbell Lowell G. Colston Glen Fishman Mike Baber Jon Bowman Shana Cooper Chad Fogelberg Jeanette Bachtold Brian Boyer Thomas S. Cosentino Joanne E. Ford Luke Bailey Jeffrey Braun Grandma Cotterell Luisa Francoeur Michael R. Baker Erika Bridges Megan Crilly Freemmaann, Sen, Anna Balek Adrienne L. Buckla Tyler Crouson Lone Wolfie and Script Fodder Sarah Bancone Linda Budelowsky Barbara Cypes Austin French Neil Barber David Burkenroad Diane D. Davis Henry M. Frieden Aida Bardardotti Layton K. Burnidge Michael De Blois Bryan Funk Greg Barnhart and family Christine Burrows Joyce A. Dentone’s son Jonathan S. Furay J.P. Barrett Janice Busigó-Cordero J.D. Derby Amelia Gagnon’s friends Jessica L. Barry The Cahillane Family Amit Desai and family Susan K. Bass Jessica L. Cain Glynn Dickens Julian Garfolo Adrienne Baumrind Shira Caldie Erin E. Dickman Jacqueline Garrett Marsha Baumrind Mary Callahan James Diggins David Gassner John C. Bayat Dr. Bruce Campbell Dr. Nancy Baird and Theodore M. Gault Brenda Beagle Jason and Michele Canapp Mr. Al Dominguez Ann Geiger Linda Beer Jim and Denise Cariani Elizabeth Dominguez and family Monique Germone Jacqueline D. Bellsey-Starr Brandon Carlton Walt Donahoe Dr. Anthony J. Giuliano Clara Bennett Sherillyn Carr Reed Donat Marina Gloria Pauline and Thomas Benson’s Son Ron Carroll Bobby Dowling Richard Gokey

BRAIN & BEHAVIOR RESEARCH FOUNDATION Suzanne Golden Ed Jones Milton and Tamar Maltz Pat Gregory Goldman Lynnan Jones Thomas Manning Jonathan Rischall and Brett Goodman Marsha Jones Stephen Marks Allison Paul-Rischall Sara Goodman Jim Kalkbrenner and son Marysol Lester Paznik Lalleh Gordy Rochelle Kaper Nancy Masopust Arthur Peck Cheryl Graba Joel H. Kaplan, M.D. Mark I. Mattern Joel M. Penny Charles Gramlich and Ann Daniel Katz June Mattila Daniel Peterson Horwitz Kauai Community Mental Center Carol Maurice Ruth A. Phillips Helen M. Gray Bill Kaung Michele Maurice W. Scot Phillips Jonathan Griffin and Lance Kawesch Hilary and Bayard Maybank Dr. Christine Piecora Maxime Jones Reverend R. Scott Keehn Kaci M. McClure Neely Piper Michael and Patricia Griffin Jason Keener Christine McDunn Carolyn A. Plumer Clara Grossman Chris Manniso and Peter McGuffin Leah Prawda Judith E. Gunther Dr. Heather A. Kennedy Cheri McLaughlin Chef Will Price Valerie Hadden Laura Kerch Joseph McMahon III Elisabeth Priller Linda Hahn Kevin Patrick McWilliams Spenser Pulley-King Haley Kevin and Joyce Jhoanne Mecija Arthur J. Radin Lisa Halpern Jonathan P. King Avery Beeson and Kimberly Meek Lois Rafal Kai Halsey-Mendez Mary Kirby Herbert Y. Meltzer, M.D. Joel E. Reed III Bonnie D. Hammerschlag Michael Kirsic Philip S. Mengel Sarah Reed Bryan Hampton Jack Kiser Elon J. Mesholam Mary A. Reichling Don Hampton Vivian Kline Jonathan M. Metcalf, LICSW David A. Reilly Henry “Hank” Hanau Steven Kofsky Daniel Michaels Rosemarie Reilly Mia Hancock Marian B. Kohlstedt John Michelich Rebecca A. Rein John K. Harrison II Timothy Krebs Ruth Michelich Sheldon and Edith Rein Kristen C. Harrison Howard and Shelley Kristol The Milbauer Family Wayne Reinholt Kenny Hart Erika Kruczkiewicz and Sylvia Milberg Brad Reuling Paul Hart her loved ones Miriam T. Miller, Esq. Min J. Ro Bernard and Mary Healy Lainie Kuklin Tali Miller David Robertson Cass Hemming Rohila Kusampudi Zia Miller Alex Rodriguez Fritz A. Henn, M.D., Ph.D. Daniel Laitman John M. Mobley Kathleen F. Rorick-McNichol Samuel Hensley The Laitman Family Regina Moller Curtis Ross The Heyd Family Elaine C. Langer Celeste Moon Faith Rothblatt Charles G. Hill Martin Langer Michael Moore Kathy L. Rottinghaus Paul and Julie Hodges Rachel LaQuercia Grisel Moreno Gregg Rubin Mary Hofert andf Anna Flaherty Jenifer T. Laschen Angelina Morisi and Kenneth Ryan Peggy Hoffman Paul T. Laun Keith Chapman Celia Rye The Hollister Family David Lavner Mark G. Morisi Jia An Sa Brianna Holman Guneet Kochar and Elizabeth S. Morningstar Lori Saltness Alexandra Holterman Julie Leber-Kochar Gregory D. Morris Christina Sanders Dave Hood Brian Lee Anne K. Muellerleile Mark A. Satterthwaite, M.D. Hope for Humanity Alice Lehman and James J. Murphy, Jr. Lori Savage Edmund and Victoria Hornstein Michael Hamburg Stephanie Murphy Jacob Saxe Kim Howie The Team at Lemuel Shattuck Julie Kindsfater and Anthony E. Schanz Josh Hudson Hospital: Unit 9 North William Murray Kai and Malia Schmelzer Kevin Hughes Harold LeRoy-New Daryl Musick Joel M. Schneider Reagan Hughes Howard Lester Kylie Mussay Shayna H. Schor Ryan Hunt Karen Levin Anne Myers David Schwartz Maryellen Hunter Karen Levin L. and A. Nadle Aaron Schwirian Joan Hursen Carol G. Levinbook Grace Nagaur Julia Scullion Angela Hurtado Daniel and Sherry Levy NAMI: Tucson Randal D. Seweryniak Kenneth Hyacinthe Jack Levy Neil Bill Sharp and family Chase Iacofano Taylor A. Levy Gary Nesenson Shelby Becca Ickowicz Bo Li, Ph.D. Lee Newton Jacqueline Shelley The Impact Team, Constance and Stephen Lieber David Novick The members of the University of Iowa Linda Victor Ochoa Shenandoah Club Louis Innamorato Jemina Linnama Sarah Ogrin Lilian Sicular Thomas R. Insel Jesse Listernick David O’Keefe Tessa Sieler Interstate Hotels & Resorts Dennis Loesch Joshua D. Okun Carolyn Sienkiewicz Jill Isenstadt Shannon Logan Matthew Oleszczak Dr. and Mrs. Mark Silver Peter Izzo Anthony Lombardy, Jr. Amy Ondracek Eli Silverman Eric T. Jager Adam Long and Jill Justice Lewis Opler, M.D., Ph.D. Gail Silverton Thomas Jandris Spencer Lucas Nieves A. Ortiz Marcia Simon-Kaplan Chris and Thea Janus Dr. Michael Lynch Patricia Page Emory Skolkin Joel H. Kaplan Shaune MacLean Chris Palmer Isabel and Marvin Slomowitz Dr. Kevin Johns Dana V. Maggi Drew Panayiotou Huan Song Andy Johnson Justin Magleby Herbert Pardes, M.D. Bernice Spandorf Jonathan and Allen Harvey Mallement Gary Pardo Penelope A. Spangler

2015 Annual Report Michael H. Sproule, Esq. Carolyn Taylor Tommy Vreeland Chris Winslow Frances B. Stanik Bilen Teklezghi Kathleen Walker The Women’s Committee: Brain & Steven Diane Temkin Robert R. Walker Behavior Dr. Desanka Stipic Laura Terio Harold Warren Research Foundation Jean Stone James C. Thies Johanna Weber Leland D. Wood Sybil Storm Vittorio and Maria Tosti Sharon Weinberg The Woodward Family Russell A. Strobel Howard Trachtman John and Jillian Weinell Judith G. Wortman Richard Stuart Mort and Susan Trew Robert Weisman The Wright Family Dean and Kelly Sulimay Tricia Christina Weiss Michael Yelenosky Andrew Sullivan John Tursi Geoffrey Wells Young Widows Frann Sullivan Paula Unger The Wells Family Eliza Young Janet Susin Martin Ureel Barbara B. White Hayley Young Jessica Suttle Kayla Van Baak Ben Widlus Alex Zeigler Jennifer Swick David L. Veritas Martin S. Willick, M.D. Jane Zemba Hillary Tae-Gomez Veterans with PTSD Brighid Willson

Memorial Tributes A loved one Kevin M. Bezonsky Joe Campbell Bobette Davis John R. Abela Deepak Bhasin Matthew Campbell Elizabeth Davis John B. Abrams Stephen J. Binder Oscar Canavan Cheryl L. Dawson Marc D. Abrams Kenneth A. Blacic Aeric G. Cannon Christine M. Dawson Vincent Acampora Chrisann Blankenship Isaac Cardona David Dawson Lary Adamson Heather A. Bleick Paul R. Carman Barbara De LaMare Carlo A. Adan David J. Block Suzanne L. Castellani Beverly De LaMare Jean M. Ahern Doris Blumenstein Robin E. Cathey A. Louise DeAngelis Nicholas R. Albers Christine M. Blyther-Galiatsatos Cathou Albert N. DeBlois Janet P. Alexander Charles F. Bodden Kevin P. Cavanaugh Ben DeCrease Mia S. Alexander Robert G. Boe Thomas P. Cavanaugh Nick DeMange Lynn Allen Susan A. Bologna Cynthia L. Cervantes Randy C. Denenberg Lori L. Altshuler, M.D. Thomas J. Bolton, Jr. Patrick Cervone Nancie D. Dennison Helen E. Amatangelo Aidan J. Bone Alfred H. Chapman Jadwiga Deren Mr. Vincent S. Amoroso, Jr. Phil Bonner Dale R. Cherney Vedant Desai Silas E. Anderson, Jr. John Boorom Matthew Cherney Katherine Deschner Ted Anderson Donald Boring Andrew S. Christie Devin Christopher Andrusz James R. Boss Glennys Christie Dana H. Dickey Christina E. Angelo Mr. Boswell Ruth G. Clark Betty Dietrich Lester Angert Amanda Bowers Michael Clateman Darleene Dina Louis Applebaum Shonda Bowman Pattie C. Clayton Brian E. Dione John A. Armbruster Joseph D. Bradshaw Philip J. Clements Daniel Disney Bonnie Arno Stamatia Brady Gary L. Cole, Sr. Kenneth Ditzel Anthony P. Arsneault Debbie Brady-Erb-Thompson Akilah B. Coleman Anthony DiVito David J. Artino Betty Brainard-Wood Oliver D. Colvin, Jr. Sylvia DiVito Daryl Attwood, Sr. David Braun Janene A. Conte Brandon Dixon John Attwood Joan Brennan, Ph.D. Ryan J. Cook Jonathan E. Dixon Robert Attwood Frank J. Brill Grace Cook-Blasingame Matthew Dodge Marion L. (Sue) Auchter Catherine A. Brodie Mary Cooney Valerie Domitrovic Jeri A. Austin Reina Brody James D. Cooper III Christopher Donovan Mary Ayling Evan Bromberg Sally Cope Lance Dorfman Patricia A. Backman Elaine C. Brooks Janet Cotugno August E. Doskey Gina M. Bailey Laura Brooks-Fast Bradley T. Couch Mike Downing Gregory T. Bak Todd P. Brown Don Coursen Rachel L. Drabenstott Robert P. Banghart Tom Brown Christopher Cowan Gerald A. Drake, M.D. Story Bannister Adam D. Bruckner Ryan R. Crookston Sandra G. Dreyfuss Scott R. Bartlett Robert Bryant Sam Cross Harriet Dublow Matthew R. Barton Edward G. Buckovich, Jr. Cordell P. Cull Kyle DuBose Carl A. Basak Todd Bunch Jeffrey N. Curtis Michael Ducate Wesley A. Baylor Walter W. Bundschuh Elizabeth H. Custer David M. Duda Doris I. Bebell Peter R. Bunning Louis Dallafior Edna Duffy Meredith W. Beck Chantal M. Burke Colter Dallman Christopher R. Dugan Scott Beery Colleen M. Burke Richard D. Daly Alan Dutka William D. Belter Sean M. Burns Mary A. D’Ambrose Duane A. Duvall Ronald Berger Margaret A. Buttino Stanley F. Dann Benjamin S. Easton Blake Bergers Michael Buxton Vincent A. Dann Ethan Edelman Patricia I. Berndt Paul C. Caisse Gerda J. Darilek Brian P. Edwards Herbert Betz Rosa Cameron Davey John J. Egan, Jr.

BRAIN & BEHAVIOR RESEARCH FOUNDATION Ken Eggena Ethel G. Gordon Sabrina I. James Mary Libby Howard A. Eklind Flora Gotz Quincy Jang Angie Libero Suzhanna Elam, M.D. Jennifer Gouvea John R. Jehle, Jr. Erma Liberty Henri Elion William P. Grace Ruth Jenkins Jacob Lichtenstein Elizabeth (Betty) Clayton J. Graham Sitaben L. Jivanbhai-Patel Melita Lichtenstein William J. Embrey Loeb H. Granoff Michael D. Johnson James Liechty Paul J. Esposito William Francis Grant 1st and 2nd Bevan Jones Jonathan Bart Lindenberg Edward Etherington Brenda Gray Kathy A. Jones Guaill Linderme Molly Everdell Linda Gray Ruth Jones Hans K. Lindgren Derek J. Everitt Stephen M. Gray Clyde A. Joseph Lina Litinskaya-Weinbaum Todd Ewen David E. Green Jeffrey C. Kain Victor G. Lottmann Daniel M. Falk Michelle Greenblatt Lawrence E. Kalom Laurie A. Loubier-Salmon Leslie E. Falzone Mary Greener Daniel D. Kane Samantha Luksik Greg Farley Mark J. Greenlee Robert J. Kannenberg William C. Lund Seymour Feinland Sharon S. Grieshaber John Z. Katz Helene Lundak Joan Feldman George R. Groninger Spencer D. Katz Shirley S. Lynne Mary Felsing Dana Gruenfelder Arthur Kaufman Marion Lynton Alec Fentum Thomas E. Guernsey Claude R. Kaufman Matthew C. Lyons John Field Thomas S. Gumport Grace B. Keller Paul K. Ma Gregory H. Fielder Linda Haas James E. Kempf Irene MacDonald Kelli A. Finkel Allen Halpern Michael F. Kenigsberg Rose MacKenzie Jonathan J. Fisher Larry A. Hans Frances Kennedy-Albert Alexis Maddock Colleen FitzGerald Matthew Hardin Gregory J. Kerr Joel R. Maginley Mary Ann Flemming Marie Hare Eric Kertzner Clare Magnus Trocar Flook Mary Lou Harriott Andy King Roman Makuch Nanako Foran Ellen E. Harris’s father John Kingry James Malcolm Todd Forehand Jordan E. Harris Jill A. Kirby Ruth Malkoff Matthew T. Fox Stewart G. Harrison Tyler S. Kirschner Sol Malkoff Celeste Fradeneck Brent A. Harshman Mabel C. Klein Brittany C. Mann Christie Fradeneck Ellen Hayes Raymond Kline Merrill M. Manning III Trey Fradeneck Michael C. Hazzard Nate Knight A loved one from Thomas J. Frangella Kevin Heald Steve Knitzer The Maolucci Family Jeffrey Frankum Kevin J. Healey Christine Kohlstedt Joanne L. Mapes Debra L. Frazier Jimmy Hehir Victor B. Koomey Alan G. Marer Robert L. Fredricksen, Jr. Bradley R. Heilman Helen Kopsky Sarah Martel-Bradley Harvey Friedenberg Frank R. Hellinger Blackhawk Pilot Daniel Koren Jacob B. Martin Irvin A. Friedman Scott L. Helt Diane Koskinas Stephen Martin Mildred Frierson Joan L. Hendricks Kieran J. Kowal Nicolás Martinez Zachary Frierson S. Henn Tosha Kowal Elizabeth Martino Jason C. Frisco LaRita Hermes-Wright Jay I. Kreider, Jr. Dorothy N. Massey Eric A. Fritts Corrections Officer 1 Kristin Ann Dolores Massey-Healy Rudolph H. Funke, Jr. Rosanna Hernandez- Kristina Geoffrey Mather-Wood J.B. Fuqua McGrantham Michael Kruczkiewicz Lorraine Matthys Mary Gallagher Harry A. Herold III Dorothy M. Kubach Thomas Matye Stan Garber Daniel M. Hess Kathleen R. Kuehlhorn Travis Matye Howard S. Garlick Mark Hibbert Rolf C. Kugler James M. Maxwell Elizabeth G. Gast Nicholas Hilbert Ilya Kurlat Ken Mayer Florence Gaydos Robert B. Hill Daniel Kyre David Mayo Joseph Gear Daniel G. Hinden Ray Lackman Elizabeth L. McAnulty William G. Geiger Sam Hochron Sadie E. Ladick Joan McCann Marvin I. George Raymond Hodge, Jr. Victor M. LaFata Esmond McCarthy Susan Getz Nicholas O. Hodgson Sheila Langlois Michael R. McCarthy William Getz Philip S. Holzman Linda Lasater’s mother Mick McClain Chandanie Ghingoor Dave Hoppe Linda Lasher Stan McClintock Dr. Irwin J. Giber Lindsey R. Hough Charlene Lat Dennis McCloskey Lynda L. Gilchrest Lucy Hu Leonard Latzman Charles McCormick Reverend Dr. T. Edward Giles Alan Hundert Jenna R. Laubach Ann McDonald Ted R. Giles William B. Hunter Robert E. Lauer Dean McDonald Joyce Gillis-Jones Milton L. Huntley Megan Lavin Elma L. McDonald Ryan C. Gilroy Margaret Hussey Nellie E. Leahy Gerald J. McDonald Kelly Gimbel Wendie Hutchings Danny Leber Kathleen McDonald-Jones Robert Gimprich Jae Y. Hyun Georgette J. LeCours Lilian P. McDowell Gregory M. Glass Conrad Igleheart Dolores Leffler Debret McFarlane Brian D. Go Jane Irwin-Malinoff Jorie Lester-Mark David McGibbon Elfrida B. Goetzenberger David N. Isler Harriett Levay Dr. Elliott McGrew Maya Gold Damaris Jackson Michael S. Levine Carolyn McNamara Alex Goldin-Krause Prayim L. Jacobsen Dr. Joanne Levy Tim McNamara Patricia Goldman-Rakic Ben Jacobson Steven Lewis Brian J. McVey

2015 Annual Report Alexander J. Meffert-Ulin Angie Pampena Mary A. Rochfort Philip A. Soignier Roderick W. Merrill Valerie Panczuk Charlie Romney Wallace E. Solo Joshua K. Messier Adam Pardee Maurice Roncalli Shirley Solomon Barbara Messinger Alison Parker Brian Rorick Warren Solomon David C. Michaels Harry C. Parker Ira Rose John T. Sommers Apphia Michelich Jeff Parker Judith Roseman Angelique Sonnier Ronald Michelich Wayne Parker Judi Rosen Martin Sorom Mikey Mike Silas Parry Dr. Henry Rosett Pauline L. Spangler Tova Milinsky Mark Patterson Mitchell S. Ross Phyllis M. Spanier Christopher J. Miller Earl M. Payne C. Frederick Rossbach Billy D. Spellman Jeff Miller Wanda Payton Eleanor Rossbach Diana Spellos Mark S. Miller Mattias J. Pena Christina Rossi Kalyani Srinivasan Lori Miller-Levine Kathleen Perachio’s mother Lewis Roth Charles R. Staab Vivian A. Mirabelli Donald S. Perrino Matthew S. Rothman Samuel R. Stack An MIT Scholar Gary M. Pesche Kelly A. Rubbo Branch Stanley Jonathan Mitchell Jay R. Peshkin Joan Rucks Brandon T. Steimel Michelle Mogan-Winiarski Peter Chris Rudder Joyce Stein Diane Mohageg Marilyn Peters-Dornan Melanie Rumuly Worth Kolne M. Stella Neil Molberger Dixon Pfefferkorn Angela S. Myron Stepack Daniel W. Momyer W. Patrick C. Phear Philippa Salisbury Karen Stern Gregory A. Monk Debra Phillips Agis Salpukas Anita B. Stevens Dr. Clairborne Moquin Keith R. Phillips JoAnn Samels LaNelle Stinnett Irene Moran’s Brother Parker E. Phillips II Elaine Samson Kathryn Stitz Lewis Morris Jeanette Piccielli Kerri N. Saunders L. Marie Strater Linda Morrison Sybil Pierce Brent R. Scanlon Mary J. Strub-Caulkins Ellen Mosher Barbara Pirto Sterling A. Schiffman Kenneth E. Stutzman Rick Mosher Robin Poist Beth Schmidt Jerome Sulzberg Richard D. Moszkowski Howard W. Pope Elizabeth Schmidt Brian Swank Vernon Mountcastle Elizabeth M. Posa Nancy Schmitt Matthew J. Szemborski Carole Muldoon Virginia F. Powell Jill Schneider Maureen Szilva Ronald P. Mullan Kirk Preuss Richard Schneider Andrew Taddy Donna Murphy John W. Price Richard B. Schreiber Jeffery R. Taillac Louise Murphy-Rhodes Oliver Priceman Dr. R. David Schreiber Vera Tartanian Cynthia A. Murray Rosemarie Princiotta Sue Schulmeister Gary Taylor Alies Muskin Philip Provenza Marilyn Schulte H. Vonn Taylor Tina M. Musso Robert G. Provisor James Schultz James E. Taylor Bob Myers Samantha A. Quinn Briana M. Schutze Ralph D. Taylor Drew Myslicki Ramez E. Qureshi Eric Schwartz Richard P. Taylor Mary Ellen Mysliwiec Daniel A. Radell Michael L. Schwartz S. Gary Tedore Malvina Nachman Marion A. Ragland Jon A. Schwenk Peter Telkins Carolyn M. Nagel Raymond Rando A. Paula Scott Jason Tennies Gitaben Naik Eileen Ratner Mark Seifter Camilla L. Thompson Steven Nannini Dr. Jacob P. Rayapati Paz Selo Fay Thompson John F. Nash, Jr. Will Raymund Werner A. Selo Marianne Thornton Gloria E. Neidorf John Reason Karen Seykora Joseph Todaro Christina D. Nelson Robbie Reck Ben Shaffer Samuel B. Todd Joel Nelson Chris G. Reese Bruce B. Shaffer Ethel M. Toepel Michael E. Nelson Marci S. Reller Me-Ira Shaindel bat Gordy Tomalty Ian D. Nicklas Michael Reschke Yekutiel ve Mindel Pau Tornero-Soria Carol R. Nielsen Norma Resnick William Shannon Frances S. Trager Mary C. Noble Mark Reuling David M. Shauger Morris Trager Edna J. Norman Nancy L. Reuschlein Alice Sherr Samuel P. Trice Dr. Gordon E. Northrup Chris Reznyk Saul Sherr Richard Trommer Norita Norton Dr. Sun Hong Rhie Harriet Shetler Donald Trybula Russ Nugent Carmella Rice Sylvia Shick Alexandros Tsaoussis-Maddock Hubert Nutt Kenneth A. Rice Tonya Shipman-Bennitt Amanda Tucci Judy A. Oakes Mareta J. Richards Shirley Shuster Donald B. Tuson Aaron Ohabi William L. Ricketts David Silbar Leon E. Tuttle Grant W. Ohlson, Jr. Rodney Riddell Annett Silva Robert Valentini Susan Okun Gregory L. Ridpath Benjamin Silver Nicolas D. Valeriano Nancy M. Olandese Elizabeth M. Rieman John T. Sinnott Stephanie L. Van Gundy Sean T. Olwell Kelsey G. Riggs Elias T. Slaman Ginny Van Nattan Cameron R. Orr Dorrit L. Rippchen Eleanor B. Slater Charles Varkoly Todd W. Orton Jan Ritchie Andrew D. Smith Elizabeth A. Varkoly Jason M. Ouellet Trandl Robbins Edmund Smith Keith A. Vinskofski Barbara W. Page David M. Robel Wayne Smith Lenore R. Vitale Pat Palma Lauren Robinson-Kieves Mary Smith-Lawrence Mark Von Dusseldorp Pamela Robert Rocheleau Linda Snow Ann Wade-Granfield

BRAIN & BEHAVIOR RESEARCH FOUNDATION William F. Wagner, Jr. James C. Welbourne Wiggles the dog G. Richard Worrell Bradley J. Wagnon Thomas J. Wendt Margaret Wills Keith C. Worrell Susan E. Waide Lisa J. Wentz Angela Wilson Beverly A. Wuntch Daniel F. Walker Timothy R. Wentz Pauletta Wilson Bobbi Young Lena Walker Heidi A. Westhoven Peter B. Wilson Richy C. Zalite Phyllis S. Walker Virginia K. Weston Richard K. Wilson Marilyn Zalokar Jameson Walls Timothy L. Whitmer Amy Winans Anna Zarski Adam Ward Christopher Whitted Dennis G. Winiarski Peter W. Zartman Ethel B. Watts-Edwards Todd Whitton Ralph Wise Andrew W. Zeh James A. Weber Eamonn D. Wholley Doug Wistner Maria Zeier Mary Weber Aaron J. Wieczorek Patricia J. Woicek Rita Zerr Penina Weiner John A. Wiederkehr II John Wolner Barry L. Zimmerman Wendy Weisman Michael G. Wieman Ivan Wood George D. Zuckerman

Community Partners

Team Up For Mental Health

$50,000+ $1,000+ Chefwich Lauren Bohlig 9th Annual Chrissy’s Wish Memorial A Day At The Beach Portland, OR Golf Outing Arlene O’Rourke Linda & Mario Rossi Hampton Bays, NY Taking Strides Against Mental Illness Manorville, NY Harryet, Rebecca, and Stuart Ehrlich Remember Johnny Charity Event Wayne, NJ Hike for Mental Health Summer Reid Leo Walker & Tom Kennedy Orange, CA Dave Green Memorial Golf Classic Appalachian Trail & Nationwide John Hagerty NAMI Eastside Support Group Dr. Tom B. Coles Glenn Dale, MD Harper Woods, MI Ribbons for Research $25,000+ Linda & Frank Kilpatrick Gaming Against Mental Illness 5th Annual Let The Sun Shine Run/Walk David O’Keefe Manhattan Beach, CA Kathy & Curt Robbins Trenton, NJ Cold Spring, MN Cynthia Crawford Birthday Party $500+ Newport News, VA Next to Normal: A Benefit Concert $10,000+ Running for Research Zachary Wobensmith Jennifer Spangler Wedding of Julie & Guneet Kochar New York, NY Midlothian, VA Overland, KS Kettlebell Swings for Kasia Fair Lawn High School 1st Annual Rory Pollack “Live to Laugh” Fundraiser Robbinsville, NJ $5,000+ Jed Downey Fair Lawn, NJ Texas A&M University Flash Zombie 5K Horizon Group Properties Mall Fundraising Alyssa Tigner Gary Skoien & Connie Dyer Wedding of Mary Hofert & Anna Flaherty College Station, TX Rosemont, IL Honolulu, HI BadNewsBaron Twitch Team Daniel: Running for Recovery from Power Planeteers Matthew Anderson Mental Illness Jee Ramos Allen, TX Drs. Ann & Robert Laitman Fresno, CA Orlando, FL & Armonk, NY Stop the Stigma Dine & Donate/Ribbon Sale “REVOFEV: The Lost Something” Film Sydney Edelson Chase Iacofano Fort Washington, PA Denver, CO

2015 Annual Report COMMUNITY Partners

With the support of family, friends and your community, you can make a difference in the fight against mental illness and the stigma it bears. When you raise money to support the Brain & Behavior Research Foundation, you not only fund the most progressive and promising brain and behavior research, but you help chip away at the crippling effect that stigma has on these illnesses. The Foundation relies on the generosity of the community to help fund leading brain and behavior research.

In 2015, local community fundraising events raised $216,000 to support brain and behavior research.

BRAIN & BEHAVIOR RESEARCH FOUNDATION Ninth Annual Chrissy’s Wish Memorial Golf Outing MANORVILLE, NY Chrissy’s Wish was established in memory of Christina Rossi and to honor the millions of people who continue to live with mental illnesses. All proceeds are donated to the Brain & Behavior Research Foundation. As a result of the fundraisers of the past seven years, together with matched funds, Chrissy’s Wish has raised more than $480,000 for the Foundation.

“Chrissy’s greatest wish was to find peace of mind. Let’s bring this wish to life. By supporting Chrissy's Wish you can help bring an end to the devastating mental disorders that strike so many our friends and family members.”

LINDA AND MARIO ROSSI, CHRISSY’S PARENTS

HIKE for Mental Health APPALACHIAN TRAIL AND NATIONALLY ACROSS THE U.S. Share the joy of hiking. Bring hope to those battling mental illness.

HIKE for Mental Health was born of a single vision: a world in which everyone, including those who suffer from mental illness, can find the simple joy of living. It’s mission is to increase public awareness of the challenges and suffering faced by those afflicted by mental illness and their families; increase public appreciation for and responsible use of wilderness trails; and to raise funds to prevent and alleviate the pain caused by mental illness while maintaining and preserving wilderness trails.

Let the Sun Shine Run/Walk to Benefit the Brain & Behavior Research Foundation COLD SPRING, MN

This event was created to honor the memory of Jonathon James Robbins. Jonathon was diagnosed with schizophrenia and depression and committed suicide on April 28, 2010 at the age of 22.

“This world WILL be a better place because of Jonathon’s death; not for us who loved him, but for all those other families out there who still have hope that a cure or better faster-acting medicine can help their loved ones.”

KATHY ROBBINS, JONATHON’S MOM 71

2015 Annual Report 2015 FINANCIAL SUMMARY

BRAIN & BEHAVIOR RESEARCH FOUNDATION 2015 Financial Summary

We are pleased to report on the financial position and results of the Brain & Behavior Research Foundation for 2015. We are appreciative and thankful for the commitment of Foundation leadership, dedicated staff, volunteers and our strong donor support base that allows the Foundation to perform its vital work. We remain indebted to the Foundation Scientific Council, our distinguished research leaders covering virtually every major discipline within brain and behavior science, who volunteer their expertise to select and recommend the most promising grant projects to fund.

In 2015, contributions continued to increase and bequests continued to provide major support for which we are deeply grateful to all of our supporters for their generosity. We again acknowledge the extraordinary bequest from the late Oliver D. Colvin, Jr. that continues to support our efforts at the Foundation. Together, all these donations further the Foundation’s mission to alleviate the suffering caused by mental illness by awarding grants that will lead to advances and breakthroughs in scientific research.

With another strong year of results, we continue to move forward with our focus of accelerating research accomplishments to help those living with mental illness to live full and productive lives. During 2015, the Foundation awarded additional NARSAD Grants to bring the total investment in mental health research to more than $342 million since inception.

We acknowledge, with great thanks and appreciation, the generosity of the two family foundations who have underwritten, once again, the Foundation's operating expenses. This allows for contributions targeted for research to go directly to funding NARSAD Grants. The financial report shown herein has been summarized from our 2015 audited financial statements. The Foundation’s complete audited financial statements and our most recent IRS Form 990 are available online at bbrfoundation.org or contact our office at 800.829.8289 for copies of the material.

2015 Annual Report Combined Statement of Financial Position

DECEMBER 31, 2015 DECEMBER 31, 2014 ASSETS

Cash and cash equivalents $14,408,546 $22,350,676 Investments, at fair value 20,664,680 11,164,075 Contributions receivable – 1,436,500 Other receivables 17,038 12,009

Pledges receivable, net 505,583 780,440

Prepaid expenses and other assets 28,612 21,415 Assets held in charitable remainder trusts 1,363,469 1,460,182 Fixed assets, net 48,577 81,617 Security deposits 77,110 77,110 $37,113,615 $37,384,024

LIABILITIES AND NET ASSETS Liabilities

Accounts payable and accrued expenses $198,788 $209,211 Grants payable 22,943,344 20,093,716 Accrued compensation 61,919 50,295 Annuities payable 791,216 871,832 Charitable gift annuities payable 301,807 317,912 Total Liabilities $24,297,074 $21,542,966 Net Assets

Unrestricted (3,606,221) (1,081,384) Unrestricted – board designated endowment 11,509,262 11,509,262 Total Unrestricted $7,903,041 $10,427,878 Temporarily restricted - 499,680 Permanently restricted 4,913,500 4,913,500 Total Net Assets $12,816,541 $15,841,058 $37,113,615 $37,384,024

BRAIN & BEHAVIOR RESEARCH FOUNDATION Combined Statement of Activities

YEAR ENDED YEAR ENDED DECEMBER 31, 2015 DECEMBER 31, 2014 SUPPORT AND REVENUE Contributions $11,608,273 $7,816,588 Special Events, net 509,498 584,805 Contribution of services 1,807,051 1,389,537 Bequests 8,847,835 21,683,838 Net realized and unrealized (losses) gains on investments (405,214) 1,184,440 Net (depreciation) appreciation of assets held in charitable remainder trusts (96,713) 55,885 Dividend and interest income 423,681 322,676 Total Support and Revenue $22,694,411 $33,037,769

EXPENSES Program Services Research grants and awards 18,441,870 22,681,953 Scientific advancement 2,293,164 1,747,843 Program support 2,544,177 2,101,977 Total Program Services $23,279,211 $26,531,773 Supporting Services Fundraising* 903,798 793,219 Administration* 1,535,919 1,346,579 Total Supporting Services $2,439,717 $2,139,798 Total Expenses $25,718,928 $28,671,571 Change in Net Assets (3,024,517) 4,366,198 Net Assets, beginning of year 15,841,058 11,474,860 End of Year Net Assets $12,816,541 $15,841,058

*All fundraising and administration expenses are funded by specially designated grants.

2015 Annual Report 90 Park Avenue, 16th floor, New York, NY 10016–1301 646.681.4888 | 800.829.8289 bbrfoundation.org

Investing in Breakthroughs To Find a Cure

100% of donor contributions for research are invested in our grants leading to advances and breakthroughs in brain and behavior research. This is made possible by the generous support of two family foundations which cover all of the Foundation’s operating expenses.

OUR MISSION: The Brain & Behavior Research Foundation is committed to alleviating the suffering caused by mental illness by awarding grants that will lead to advances and breakthroughs in scientific research.

HOW WE DO IT: The Foundation funds the most innovative ideas in neuroscience and psychiatry to better understand the causes and develop new ways to treat brain and behavior disorders. These disorders include depression, bipolar disorder, schizophrenia, autism, attention-deficit hyperactivity disorder, anxiety, borderline personality disorder, chemical dependency, obsessive-compulsive disorder and post-traumatic stress disorders.

OUR CREDENTIALS: Since 1987, we have awarded more than $342 million to fund more than 5,000 grants to more than 4,000 scientists around the world.

OUR VISION: To bring the joy of living to those affected by mental illness—those who are ill and their loved ones.

BRAIN & BEHAVIOR RESEARCH FOUNDATION