Hindawi Publishing Corporation Advances in Urology Volume 2011, Article ID 812368, 21 pages doi:10.1155/2011/812368 Review Article The Strong Protective Effect of Circumcision against Cancer of the Penis Brian J. Morris,1 Ronald H. Gray,2 Xavier Castellsague,3 F. Xavier Bosch, 3 Daniel T. Halperin,4 Jake H. Waskett,5 and Catherine A. Hankins6 1 School of Medical Sciences and Bosch Institute, Sydney Medical School, The University of Sydney, Sydney, NSW 2006, Australia 2 Population and Family Planning, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA 3 Institut Catal`a d’Oncologia (ICO), IDIBELL, CIBERESP, RTICC, 08908 L’Hospitalet de Llobregat, Catalonia, Spain 4 Department of Global Health and Population, Harvard School of Public Health, Boston, MA 02115, USA 5 Circumcision Independent Reference and Commentary Service, Radcliffe, Manchester M261JR, UK 6 Joint United Nations Programme on HIV/AIDS, 1211 Geneva, Switzerland Correspondence should be addressed to Brian J. Morris,
[email protected] Received 15 December 2010; Accepted 9 March 2011 Academic Editor: Philippe E. Spiess Copyright © 2011 Brian J. Morris et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Male circumcision protects against cancer of the penis, the invasive form of which is a devastating disease confined almost exclusively to uncircumcised men. Major etiological factors are phimosis, balanitis, and high-risk types of human papillomavirus (HPV), which are more prevalent in the glans penis and coronal sulcus covered by the foreskin, as well as on the penile shaft, of uncircumcised men.